CN103520267A - Wettable experimental pullorum evapotranspiration and preparation method thereof - Google Patents
Wettable experimental pullorum evapotranspiration and preparation method thereof Download PDFInfo
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- CN103520267A CN103520267A CN201310530949.8A CN201310530949A CN103520267A CN 103520267 A CN103520267 A CN 103520267A CN 201310530949 A CN201310530949 A CN 201310530949A CN 103520267 A CN103520267 A CN 103520267A
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Abstract
The invention relates to the technical field of veterinary medicine preparation, in particular to wettable experimental pullorum evapotranspiration and a preparation method thereof. A suspending agent is added to the wettable experimental pullorum evapotranspiration based on original effective composition of herbs, and through reasonable medicine matching, the wettable experimental pullorum evapotranspiration is easy to scatter evenly in water, and beneficial to dosing during water drinking. Compared with commercially available experimental pullorum evapotranspiration, the wettable experimental pullorum evapotranspiration is good in therapeutic effect and convenient to use. The preparation method of the wettable experimental pullorum evapotranspiration is simple in technology, low in production cost, and suitable for industrial mass production.
Description
Technical field
The present invention relates to technical field of animal remedy preparation, be specifically related to a kind of wettability dysentery relieving and fall apart and preparation method thereof.
Background technology
The Traditional Chinese medicine historical preparation that dysentery relieving San Shi People's Republic of China (PRC) veterinary drug allusion quotation is recorded, is comprised of Realgar, Herba Pogostemonis, Talcum 3 taste Chinese medicines, has heat-clearing and toxic substances removing, removing dampness dysentery-stopping efficacy, cures mainly piglet pujos blancos.In side, the removing toxic substances of Realgar dampness, is monarch drug; Herba Pogostemonis removing dampness by means of aromatics and middle preventing or arresting vomiting, the loose pathogenic factor in the exterior of a surname, promoting qi circulation, resolving food retention are ministerial drug; Talcum eliminating dampness and diuresis, clearing away heat to stop diarrhea are adjuvant drug.
Realgar is one of sulfide mineral of arsenic, containing As approximately 70.1%.Modern pharmacology research shows: Realgar has broad-spectrum antiseptic, antivirus action, Realgar has and suppresses and killing action staphylococcus aureus, streptococcus, white chain pearl bacterium, pyococcus, dysentery bacterium, escherichia coli, tubercule bacillus and multiple fungus, virus, Mus plasmodium and Schistosoma japonicum, can also strengthen the phagocytic activity of RES, improve the non-specific immunity of body.
Herba Pogostemonis is the herb of labiate Herba Pogostemonis or herba agastachis rugosae.Herba Pogostemonis has stronger inhibitory action to gold-coloured staphylococci, hemophilus influenza, streptococcus pneumoniae and multiple digestive tract cause of disease bacterium, and multiple virus, fungus and leptospira are had to inhibition and killing action in various degree.It is fragrant that Herba Pogostemonis has another name called branch, and its main medicinal ingredient is patchouli oil, and content is about 0.33%.Patchouli oil has antiinflammatory, antiallergic, raising immunity, antibiotic, analgesia, spasmolytic, antioxidation, antiemetic effect.In 2005 editions " pharmacopeia ", common Herba Pogostemonis preparation is as often added patchouli oil to replace Herba Pogostemonis in HUOXIANGZHENGQI KOUFUYE, HUOXIANG ZHENGQI SHUI, HUOXIANG ZHENGQI RUANJIAONANG.Herba agastachis rugosae has another name called Du Herba Pogostemonis, and containing volatile oil 0.28%～0.54%, wherein main component is estragole, and content is about 0.3%.Estragole can improve the environment in digestive tract, Gastrointestinal motility adjustment and secretion, facilitating digestion function; To the slow motion function that promotes of gastrointestinal motility, and there are good spasmolytic, preventing or arresting vomiting, town to tell effect to gastrointestinal convulsion; Therefore, estragole also can be used as the substitute products of Herba Pogostemonis.
Talcum is a kind of common silicate mineral, and quality is soft and have a satiny feel.Oxidized ferrous replacement of magnesium oxide in Talcum (MgO) component portion, thereby skin and mucosa are had to protective effect; Pulvis Talci is because granule is little, and the gross area is large, can adsorb a large amount of chemical irritants or poisonous substance; Can form overlay film at mucosa or skin ulcer face, reduce local chemistry and mechanical stimulus; Simultaneously again can absorptive tissue abnormal secretion thing and inflammatory exudate, therefore can promote tissue repair; After Pulvis Talci is for oral administration, can also protect gastrointestinal mucosa, performance antiinflammatory, antidiarrheal efficacy.
Realgar during dysentery relieving is loose through with Talcum, Herba Pogostemonis compatibility after, toxicity is starkly lower than the Realgar of equivalent homogeneity, through acute counteracting toxic substances research, shows, it is safe by the medication of pharmacopeia prescribed dose that dysentery relieving falls apart.Veterinary clinic is used for the treatment of that feeding and management is bad, the taste due to evil, the feed mold of diseases caused by exogenous pathogenic factor cold-damp are impaired, transformation failure of spleen or infected the piglet pujos blancos causing by Escherichia coli.
As a kind of determined curative effect, few side effects and cheap Chinese patent medicine, dysentery relieving is loose to be applied in livestock-raising production with traditional powder form.Although this dosage form can play therapeutic effect aborning, during application, still have some restrictions.Powder can only be fed or the mode of spice is offerd medicine by filling in use, and filling with to feed wastes time and energy, and is not suitable for a fairly large number of group support animal; Spice is applicable to group support animal, but while using medicine and feedstuff mix homogeneously more difficult, easily cause animal to take the photograph dose too much poisoning or take the photograph the situation of the very few inefficacy of dose.
In order better to promote dysentery relieving, be dispersed in the application in relative scale, intensive modern times cultivation, overcome the deficiency of existing dosage form, develop and be a kind ofly easy in water dispersedly, the loose novel form of dysentery relieving that is beneficial to drinking-water administration is very necessary.
Summary of the invention
In view of this, the invention provides a kind of wettability dysentery relieving loose, on the basis of original effective ingredient, added suspending agent, by rational drug ratio, provide a kind of be easy in water dispersed, the wettability dysentery relieving that is beneficial to drinking-water administration is loose, compares with commercially available dysentery relieving is loose, and the loose therapeutic effect of wettability dysentery relieving is good, easy to use; The present invention also provides a kind of wettability dysentery relieving loose preparation method, and the method technique is simple, and low production cost is applicable to industrialized great production.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of wettability dysentery relieving loose, the raw material that comprises following weight portion:
In some embodiments of the invention, the Bales Off of wettability dysentery relieving contains the raw material of following weight portion:
In other embodiment of the present invention, the Bales Off of wettability dysentery relieving contains the raw material of following weight portion:
In other embodiment of the present invention, the Bales Off of wettability dysentery relieving contains the raw material of following weight portion:
As preferably, cyclodextrin is a kind of or both the above mixture in alpha-cyclodextrin, beta-schardinger dextrin-or gamma-cyclodextrin; Cyclodextrin can also substitute with cyclodextrin derivative.
As preferably, suspending agent is a kind of or both the above mixture in sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, xanthan gum, arabic gum or tragakanta; Can also there is the adjuvant of suspending agent effect for other of field of veterinary.
As preferably, the loose raw material of wettability dysentery relieving also comprises correctives.
As preferably, the scope of correctives is 0.1～2.6 weight portion, and the scope of preferred correctives is 0.3～2.6 weight portion; Most preferred, the scope of correctives is 0.25～0.67 weight portion.
In some embodiments of the invention, wettability dysentery relieving is loose is made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
In other embodiment of the present invention, wettability dysentery relieving is loose to be made by the raw material of following weight portion:
As preferably, correctives is a kind of or both the above mixture in fresh milk essence, fruit essence, sucralose, neotame, saccharin sodium or glucide; Can also can be applicable to for other sweeting agent, flavouring agent or the tasty agents of veterinary drug.
As preferably, correctives comprises a kind of in flavouring agent or sweeting agent or both mixture.
Preferred, correctives is the mixture of flavouring agent and sweeting agent.
Preferred, flavouring agent comprises the above mixture of any one or both in fresh milk essence and fruit essence.
Preferred, sweetener packets is containing a kind of or both the above mixture in sucralose, neotame, saccharin sodium or glucide.
Most preferred, the scope of flavouring agent is 0～1 weight portion.
Most preferred, the scope of sweeting agent is 0～1.6 weight portion.
Preferred, correctives is the mixture of fresh milk essence and saccharin sodium.
The effect of loose each raw material of wettability dysentery relieving of the present invention is as follows:
Realgar: Realgar has broad-spectrum antiseptic, antivirus action.Realgar has and suppresses and killing action staphylococcus aureus, streptococcus, white chain pearl bacterium, pyococcus, dysentery bacterium, escherichia coli, tubercule bacillus and multiple fungus, virus, Mus plasmodium and Schistosoma japonicum, can also strengthen the phagocytic activity of RES, the non-specific immunity that improves body is principal agent.
Talcum: Talcum has protective effect to skin and mucosa, has antiinflammatory, antidiarrheal efficacy, is principal agent.
Herba Pogostemonis, estragole or patchouli oil: all having antiinflammatory, antiallergic, raising immunity, antibiotic, analgesia, spasmolytic, antioxidation, antiemetic effect, is principal agent.
Cyclodextrin: cyclodextrin can increase dissolubility and the dissolution velocity of the bad medicine of some water solublity in water effectively; It can also make volatile oil become pressed powder by liquid by clathration, reduces volatilization, and this has not only improved medicine stability, and is convenient to volatile oil and makes various preparations; In addition, cyclodextrin can also reduce bad smell or the bitterness of medicine, reduces zest and the toxic and side effects of medicine.
Suspending agent: the suspending agents such as sodium carboxymethyl cellulose can increase the viscosity of disperse medium, thus the sedimentation velocity of microgranule or the hydrophilic of increase microgranule reduced.
Correctives: the correctivess such as fresh milk essence, saccharin sodium can improve the palatability of medicine, the faunichron having a sharp sense of taste for pig etc., has luring function.
The present invention also provides a kind of wettability dysentery relieving loose preparation method, comprises the following steps:
A) take respectively the raw material of following weight portion:
B) raw material is mixed, be crushed to 625 order～6250 object fine powders and get final product.
Preferably, the preparation method Raw that wettability dysentery relieving is loose also comprises correctives.
In preparation process, raw material can first mix and pulverize, and also can first pulverize and remix, and finally reaches uniform mixture fine powder object, and pulverizing order number can be any number between 625～6250.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) get Realgar, Talcum, suspending agent mixing, be crushed to 625 order～6250 object fine powders;
C) get fine powder and mix with Herba Pogostemonis oil, pack and get final product.
Preferably, the preparation method Raw that wettability dysentery relieving is loose also comprises correctives.
In preparation process, Realgar, Talcum, suspending agent can first mix and pulverize, also can first pulverize and remix, finally reach uniform mixture fine powder object, pulverizing order number can be any number between 625～6250, in step c), fine powder and patchouli oil mixed process answer rapid mixing even, to avoid the volatilization of patchouli oil.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
Preferably, the preparation method Raw that wettability dysentery relieving is loose also comprises correctives.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
Preferably, the preparation method Raw that wettability dysentery relieving is loose also comprises correctives.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
Preferably, the preparation method Raw that wettability dysentery relieving is loose also comprises correctives.
In preparation process, Realgar, Talcum, suspending agent can first mix and pulverize, also can first pulverize and remix, finally reach uniform mixture fine powder object, pulverizing order number can be any number between 625～6250, in step c), fine powder and patchouli oil mixed process answer rapid mixing even, to avoid the volatilization of patchouli oil.
In some embodiments of the invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) raw material is mixed, be crushed to 625 order～6250 object fine powders and get final product.
In preparation process, raw material can first mix and pulverize, and also can first pulverize and remix, and finally reaches uniform mixture fine powder object, and pulverizing order number can be any number between 625～6250.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) get Realgar, Talcum, suspending agent, correctives mixing, be crushed to 625 order～6250 object fine powders;
C) get fine powder and mix with Herba Pogostemonis oil, pack and get final product.
In preparation process, Realgar, Talcum, suspending agent, correctives can first mix and pulverize, also can first pulverize and remix, finally reach uniform mixture fine powder object, pulverizing order number can be any number between 625～6250, in step c), fine powder and patchouli oil mixed process answer rapid mixing even, to avoid the volatilization of patchouli oil.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent, correctives are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent, correctives are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
In other embodiment of the present invention, the preparation method that wettability dysentery relieving is loose comprises the following steps:
A) take respectively the raw material of following weight portion:
B) Realgar, Talcum, suspending agent, correctives are mixed, be crushed to 625 order～6250 object fine powders;
C) get cyclodextrin and mix with water, be heated to 50 ℃, mix with estragole, constant temperature stirs 1h, cold preservation 24h, then the fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
In preparation process, raw material Realgar, Talcum, suspending agent, correctives can first mix and pulverize, also can first pulverize and remix, finally reach uniform mixture fine powder object, pulverizing order number can be any number between 625～6250, in step c), dry temperature can be any number between 40 ℃～50 ℃, and dry can be aeration-drying or non-aeration-drying.Wettability dysentery relieving provided by the invention is loose easily dispersed for a long time in water, is beneficial to drinking-water administration, is applicable to large-scale farming, wettability dysentery relieving loose can also be by being sprayed on feedstuff, the direct form administration of spice or drug administration by injection.
The invention provides a kind of wettability dysentery relieving loose, the raw material that comprises following weight portion: Realgar 12.9～20 weight portions; Talcum 48.3～75 weight portions; Herba Pogostemonis, estragole or patchouli oil 0.106～50 weight portion; Cyclodextrin 0～10 weight portion; Suspending agent 1.75～14 weight portions; Preferably, the loose raw material of wettability dysentery relieving also comprises correctives, and preferred, correctives is 0.1～2.6 weight portion.During wettability dysentery relieving is loose, add suspending agent, improved significantly Realgar, Talcum, Herba Pogostemonis, estragole or the patchouli oil dispersibility in water, it is evenly distributed in water for a long time, facilitate clinical in drinking-water administration; Add correctives, can greatly improve the palatability of medicine, not only can also can be applicable to the sharp-nosed animals such as pig for quick animals that has a bad nose such as chickens, applied widely; The faunichron having a sharp sense of taste for pig etc., has luring function.Formulation screening test shows, wettability dysentery relieving provided by the invention is loose can be dispersed in water, sedimentation velocity is slow, is beneficial to clinical drinking-water administration; And good palatability, pig is had to luring function.The clinical tests result of piglet pujos blancos is shown, wettability dysentery relieving provided by the invention is loose has good therapeutic effect to piglet pujos blancos; Compare with commercially available dysentery relieving is loose, therapeutic effect is significantly increased, and easy to use, applied widely.Therefore, the invention provides and be a kind ofly easy in water dispersedly, the wettability dysentery relieving that is beneficial to drinking-water administration is loose, compares with commercially available dysentery relieving is loose, and the loose therapeutic effect of wettability dysentery relieving is good, easy to use; In certain embodiments, owing to adding correctives in formula, improve palatability of drugs, expanded the scope of application of medicine.The present invention also provides a kind of wettability dysentery relieving loose preparation method, and the method technique is simple, and low production cost is applicable to industrialized great production.
Below in conjunction with the specific embodiment, the present invention is described in further detail.
The specific embodiment
The invention provides a kind of wettability dysentery relieving and fall apart and preparation method thereof, those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can change methods and applications as herein described or suitably change and combination within not departing from content of the present invention, spirit and scope, realizes and apply the technology of the present invention.
The present invention tests to illustrate the loose beneficial effect of wettability dysentery relieving of the present invention by screening test and the animal clinical tests of formula.
For pharmaceutical composition, supplementary product kind, consumption and auxiliary material combination etc., be the key factor of preparation, and can they be directly connected to the quality that obtain said preparation and the quality of the pharmaceutical preparations that obtains.For wettability dysentery relieving of the present invention is loose, main investigation index is dispersion and sedimentation velocity.Dispersion detects and medicine can be dropped in water, observes or stirs and observe its deployment conditions, and then judging that whether dispersion is qualified.Sedimentation velocity detects can An《 People's Republic of China (PRC) veterinary drug allusion quotation (version in 2010) " in appendix " solution for oral administration, suspensoid for oral administration, Emulsion for oral administration " settling volume than inspection technique requirement, the formula settling volume ratio that wettability dysentery relieving in embodiment is loose is measured, and then judged that whether product is qualified.
During drinking water for animals administration, the poor veterinary drug of some palatabilities is owing to having the bad taste of smelling, and can cause the animal amount of drinking of the sense of taste sensitivities such as pig to reduce and even not drink, thereby be difficult for reaching the therapeutic effect of expection.Therefore, the palatability of veterinary drug has larger impact for the curative effect of veterinary drug.The method that palatability detects: veterinary drug is converted to drinking water by quantity, drink for healthy swinery, observe the drinking-water situation of swinery, whether the palatability of evaluating medicine with this is good.
In the present invention, the test of animal clinical tests adopts piglet pujos blancos clinical tests is tested.Piglet pujos blancos is a kind of infectious intestinal disease of piglet, is mainly in 10-30 age in days, and sick pork chop white, canescence or the stench loose stool of yellow-white, be mainly living condition and be not suitable for, and has bad physiques, and escherichia coli etc. seize the opportunity movable institute and cause.Dysentery relieving is loose can suppress colibacillary growth, and piglet pujos blancos is had to good therapeutic effect.In clinical trial of the present invention, respectively by the loose and commercially available loose treatment that is applied to piglet pujos blancos of dysentery relieving of wettability dysentery relieving provided by the invention, by the contrast of the two curative effect, demonstrated outstanding advantage of the present invention.The two administering mode is different, the loose direct spice of dysentery relieving or mix medicated porridge feeding, and the loose mode administration that can add by drinking-water of wettability dysentery relieving, the amount of drinking water of general sick pig is greater than feed intake.Therefore,, in clinical trial, the active drug concentration in feedstuff is greater than the concentration of active drug in drinking-water.
Formulation screening test shows, wettability dysentery relieving provided by the invention is loose can be dispersed in water, sedimentation velocity is slow, is beneficial to clinical drinking-water administration; And good palatability, pig is had to luring function.The clinical tests result of piglet pujos blancos is shown, wettability dysentery relieving provided by the invention is loose has good therapeutic effect to piglet pujos blancos; Compare with commercially available dysentery relieving is loose, therapeutic effect is significantly increased, and easy to use, applied widely.Therefore, the invention provides and be a kind ofly easy in water dispersedly, the wettability dysentery relieving that is beneficial to drinking-water administration is loose, compares with commercially available dysentery relieving is loose, and the loose therapeutic effect of wettability dysentery relieving is good, easy to use; In certain embodiments, owing to adding correctives in formula, improve palatability of drugs, expanded the scope of application of medicine; The present invention also provides a kind of wettability dysentery relieving loose preparation method, and the method technique is simple, and low production cost is applicable to industrialized great production.
Wettability dysentery relieving provided by the invention is loose in piglet pujos blancos clinical trial, and raw materials used source is as follows:
Dysentery relieving is loose: manufacturer is Chengdu Qiankun Animal Drug Industry Co., Ltd.; Veterinary drug word (2011) 220225037; Every 300g dysentery relieving is loose containing Realgar 40g, Herba Pogostemonis 110g, Talcum 150g; Consumption is: piglet 2～4g.
Experimental animal: 125 of the sick pigs of piglet pujos blancos of pig farm, Pixian County natural occurrence are coli-infection through laboratory diagnosis.
Below in conjunction with embodiment, further set forth the present invention:
The formula screening that embodiment 1 wettability dysentery relieving of the present invention is loose
Screening formula as filled a prescription 1 in table 1～fill a prescription as shown in the of 7:
The screening formula of table 1 wettability dysentery relieving of the present invention powder formula
Take respectively and in table 1, fill a prescription 1～raw material of each weight percentage in 7 of filling a prescription, by Realgar, Talcum, xanthan gum, fresh milk essence, saccharin sodium mix homogeneously, be crushed to 625 object impalpable powders standby; Get beta-schardinger dextrin-, add water 30kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, cold preservation 24 hours, the impalpable powder that adds above preparation, mix homogeneously, 40 ℃ of aeration-dryings, pack, obtain by the formula 1～7 wettability dysentery relieving that make of filling a prescription loose.
Formula 1～7 wettability the dysentery relieving that make of filling a prescription are fallen apart and carry out dispersion quality evaluation, the evaluation of settling volume specific mass and palatability quality evaluation.
Dispersion quality evaluation: get by loose each 1g of the wettability dysentery relieving of 1～7 preparations of filling a prescription of filling a prescription in table 1, drop into respectively in 1000mL drinking water, observe or stir and observe its deployment conditions, dispersion evaluation criterion is as shown in table 2:
Table 2 dispersion evaluation criterion
Settling volume specific mass is evaluated: get loose each 0.25g of wettability dysentery relieving of formula 1～7 preparations of filling a prescription, be placed in respectively 50mL tool plug graduated cylinder, add water to 50mL, fill in closely, firmly jolting 1min, records respectively suspended matter height, calculated settlement volume ratio.
Computing formula:
Settling volume ratio=H/H
0
Wherein, H
0for suspended matter elemental height; H is the height of standing 3 hours suspended matters.
Criterion of acceptability: settling volume ratio >=0.90.
Palatability quality evaluation: by converting drinking water by 0.1% concentration respectively by the wettability dysentery relieving of 1～7 preparations of filling a prescription of filling a prescription in table 1 is loose, drink for healthy swinery, observe and record swinery and drink situation, choose palatability grade, evaluation criterion is as shown in table 3.
Table 3 Palatability evaluation standard
| opinion rating | evaluation criterion |
| excellent | when the drinking-water of dosing is provided, swinery is induced by abnormal smells from the patient, initiatively fights for and drinks. |
| good | when the drinking-water of dosing is provided, swinery is drunk by daily drinking habit. |
| poor | when the drinking-water of dosing is provided, swinery refusal is drunk or the amount of drinking decline relatively usually. |
Result of the test is as shown in table 4:
The table 4 wettability dysentery relieving of the present invention quality evaluation result of faling apart
The listed evaluation index of his-and-hers watches 4 is carried out comprehensive analysis and can be obtained: by screening the 1～7 wettability dysentery relieving that make of filling a prescription of filling a prescription are loose, obtained being uniformly dispersed, sedimentation velocity is slow and the wettability dysentery relieving of good palatability is loose, 2～7 wettability the dysentery relieving that make of filling a prescription of wherein filling a prescription are loose has all reached qualified level, take again fill a prescription 3 and formula 4 be optimum.
As can be seen here, wettability dysentery relieving provided by the invention is dispersed in water and is uniformly dispersed, stablizes, and can adopt the mode administration of drinking-water interpolation, greatly reduces the working strength of administration; And the loose good palatability of wettability dysentery relieving, not only can also can be applicable to the sharp-nosed animals such as pig for quick animals that has a bad nose such as chickens, applied widely; Wettability dysentery relieving falls apart the effect of food calling while being applied to the sharp-nosed animals such as pig.
The loose preparation of embodiment 2 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, after mix homogeneously, be crushed to 625 object impalpable powders, packing, obtains wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 3 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, xanthan gum, fresh milk essence, glucide, sucralose mix homogeneously, be crushed to 625 object impalpable powders standby; Get beta-schardinger dextrin-, add water 30kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, and cold preservation 24 hours adds the impalpable powder of above preparation, mix homogeneously, 42 ℃ dry, packs, and obtains wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 4 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, tragakanta, fruit essence, saccharin sodium mix homogeneously, be crushed to 2000 object fine powders; Add Herba Pogostemonis oil mix homogeneously, pack and obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 5 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, xanthan gum, tragakanta, sucralose, fruit essence mix homogeneously, be crushed to 6250 object impalpable powders standby; Get alpha-cyclodextrin, add water 29kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, and cold preservation 24 hours adds the impalpable powder of above preparation, mix homogeneously, 45 ℃ of aeration-dryings, pack, and obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 6 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, xanthan gum, fresh milk essence, glucide mix homogeneously, be crushed to 6250 object impalpable powders standby; Get gamma-cyclodextrin, add water 45kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, and cold preservation 24 hours adds the impalpable powder of above preparation, mix homogeneously, 48 ℃ of aeration-dryings, pack, and obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 7 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, xanthan gum mix homogeneously, be crushed to 6250 object impalpable powders standby; Get gamma-cyclodextrin, add water 32kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, and cold preservation 24 hours adds the impalpable powder of above preparation, mix homogeneously, 50 ℃ of aeration-dryings, pack, and obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 8 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, sodium carboxymethyl cellulose, fresh milk essence, neotame mix homogeneously, be crushed to 625 object impalpable powders standby; Get alpha-cyclodextrin, beta-schardinger dextrin-, add water 28kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, cold preservation 24 hours, the impalpable powder that adds above preparation, mix homogeneously, 43 ℃ of aeration-dryings, pack, obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 9 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methylcellulose, fresh milk essence mix homogeneously, pulverize 625 object impalpable powders standby; Get beta-schardinger dextrin-, gamma-cyclodextrin, add water 35kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, cold preservation 24 hours, the impalpable powder that adds above preparation, mix homogeneously, 47 ℃ of aeration-dryings, pack, obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 10 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, arabic gum, sodium carboxymethyl cellulose, glucide mix homogeneously, be crushed to 4500 object fine powders; Add Herba Pogostemonis oil mix homogeneously, pack and obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 11 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, arabic gum, fruit essence mix homogeneously, be crushed to 6250 object impalpable powders standby; Get alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, add water 40kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, cold preservation 24 hours, the impalpable powder that adds above preparation, mix homogeneously, 45 ℃ of aeration-dryings, pack, obtain wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 12 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, after mix homogeneously, be crushed to 6250 object impalpable powders, packing, obtains wettability dysentery relieving of the present invention loose.
The loose preparation of embodiment 13 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, after mix homogeneously, be crushed to 6000 object impalpable powders, packing, obtains the loose 300kg wettable powder (being equivalent to crude drug 290kg) of dysentery relieving of the present invention.
The loose preparation of embodiment 14 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, sodium carboxymethyl cellulose, sucralose mix homogeneously, be crushed to 625 object fine powders; Add Herba Pogostemonis oil mix homogeneously, pack and obtain the loose 200kg(of wettability dysentery relieving of the present invention and be equivalent to crude drug 300kg).
The loose preparation of embodiment 15 wettability dysentery relieving of the present invention
Formula:
Take above-mentioned raw materials, by Realgar, Talcum, sodium carboxymethyl cellulose, fresh milk essence, glucide mix homogeneously, be crushed to 6250 object impalpable powders standby; Get beta-schardinger dextrin-, add water 30kg, be stirred to dissolve and be heated to 50 ℃, slowly add while stirring estragole, constant temperature stirs 1 hour, cold preservation 24 hours, the impalpable powder that adds above preparation, mix homogeneously, 49 ℃ of aeration-dryings, pack, obtain the loose 200kg(of wettability dysentery relieving of the present invention and be equivalent to crude drug 300kg).
The loose clinical tests to piglet pujos blancos of embodiment 16 wettability dysentery relieving
Select the substantially suitable sick pig that suffers from piglet pujos blancos of body weight, in same pig house, under identical raising condition, be divided at random following 3 groups:
Blank group: establish 9 of disease pigs, by daily feeding manner feedwater feed, not administration, observes 3 days.
Positive controls: establish 16 of disease pigs, mix medicated porridge by 0.5g/kg.bw and feed with commercially available dysentery relieving is loose, every day 2 times, be used in conjunction 2 days, continue after drug withdrawal to observe 1 day.
Test group: establish 100 of disease pigs, test group is fallen apart and converted drinking water by 0.3g/kg.bw with wettability dysentery relieving prepared by embodiment 15, drinks for sick pig, every day 2 times, is used in conjunction 2 days, continues to observe 1 day after drug withdrawal.
After 2 days, observe disease pig spirit appetite situation and make statistics, and calculating cure rate, obvious effective rate, effective percentage and inefficiency, curative effect determinate standard is as shown in table 5.
Table 5 curative effect determinate standard
| therapeutic effect | judge index |
| recovery from illness | after 3 days, it is normal that spiritual appetite is recovered, clinical symptom disappearance. |
| effective | after 3 days, spiritual appetite takes a turn for the better, clinical symptom disappearance or alleviate. |
| invalid | after 3 days, symptom is not improved. |
Computing formula:
Cure rate=recovery from illness case quantity/case sum * 100%
Obvious effective rate=effective case quantity/case sum * 100%
Effective percentage=cure rate+obvious effective rate
Inefficiency=Ineffective Cases quantity/case sum * 100%
Result of the test is as shown in table 6.
The loose clinical tests result to piglet pujos blancos of table 6 wettability dysentery relieving
From the result of the test shown in table 6, medication is after 3 days, and blank group effective percentage is 0, and positive controls and test group effective percentage are 100%, and showing that dysentery relieving is loose and wettability dysentery relieving is loose all has good curative effect to piglet pujos blancos; And test group cure rate (96%) is significantly higher than the cure rate (87.5%) of positive controls; Repeatedly repeated trials shows, test repeatability is good.As can be seen here, to be significantly better than (P < 0.05) commercially available dysentery relieving loose for the loose therapeutic effect of wettability dysentery relieving provided by the invention; In sum, wettability dysentery relieving is loose has good curative effect to piglet pujos blancos, and therapeutic effect to be significantly better than commercially available dysentery relieving loose.
In process of the test, find, with commercially available loose the comparing of dysentery relieving, wettability dysentery relieving provided by the invention is loose easy to use, greatly reduces the working strength of administration; Due to the mode administration of taking drinking-water to add, the loose feed intake of disease pig that in use do not affect of wettability dysentery relieving of the present invention.
In addition,, owing to having added correctives in wettability dysentery relieving powder formula, good palatability, not only can also can be applicable to the sharp-nosed animals such as pig for quick animals that has a bad nose such as chickens, applied widely; While being applied to the sharp-nosed animals such as pig, there is the effect of food calling.
During the loose clinical tests that is applied to piglet pujos blancos of wettability the dysentery relieving respectively embodiment of the present invention 1～14 being provided is tested, test method is with embodiment 16, obtained experimental result is similar to embodiment 16 result of the tests, and it is loose that the loose therapeutic effect of wettability dysentery relieving providing in other embodiments of the invention is all significantly better than (P < 0.05) commercially available dysentery relieving.
Comprehensive above-mentioned result of the test: the invention provides and be a kind ofly easy in water dispersedly, the wettability dysentery relieving that is beneficial to drinking-water administration is loose, compares with commercially available dysentery relieving is loose, and the loose therapeutic effect of wettability dysentery relieving is good, easy to use; In certain embodiments, owing to adding correctives in formula, improve palatability of drugs, expanded the scope of application of medicine.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (14)
1. a wettability dysentery relieving is loose, it is characterized in that the raw material that it comprises following weight portion:
2. wettability dysentery relieving according to claim 1 is loose, it is characterized in that the raw material that it comprises following weight portion:
3. wettability dysentery relieving according to claim 1 is loose, it is characterized in that the raw material that it comprises following weight portion:
4. wettability dysentery relieving according to claim 1 is loose, it is characterized in that the raw material that it comprises following weight portion:
5. loose according to the wettability dysentery relieving described in claim 1 to 4 any one, it is characterized in that, described cyclodextrin is a kind of or both the above mixture in alpha-cyclodextrin, beta-schardinger dextrin-or gamma-cyclodextrin.
6. loose according to the wettability dysentery relieving described in claim 1 to 4 any one, it is characterized in that, described suspending agent is a kind of or both the above mixture in sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, xanthan gum, arabic gum or tragakanta.
7. loose according to the wettability dysentery relieving described in claim 1 to 4 any one, it is characterized in that, described raw material also comprises correctives.
8. wettability dysentery relieving according to claim 7 is loose, it is characterized in that, described correctives is a kind of or both the above mixture in fresh milk essence, fruit essence, sucralose, neotame, saccharin sodium or glucide.
9. wettability dysentery relieving according to claim 7 is loose, it is characterized in that, described correctives is the mixture of fresh milk essence and saccharin sodium.
10. the loose preparation method of wettability dysentery relieving as claimed in claim 1, is characterized in that, comprises the following steps:
A) take respectively the raw material of following weight portion:
B) described raw material is mixed, be crushed to 625 order～6250 object fine powders and get final product.
11. 1 kinds of loose preparation methoies of wettability dysentery relieving as claimed in claim 1, is characterized in that, comprise the following steps:
A) take respectively the raw material of following weight portion:
B) get described Realgar, described Talcum, the mixing of described suspending agent, be crushed to 625 order～6250 object fine powders;
C) get described fine powder and mix with described Herba Pogostemonis oil, pack and get final product.
12. 1 kinds of loose preparation methoies of wettability dysentery relieving as claimed in claim 1 or 2, is characterized in that, comprise the following steps:
A) take respectively the raw material of following weight portion:
B) described Realgar, described Talcum, described suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get described cyclodextrin and mix with water, be heated to 50 ℃, mix with described estragole, constant temperature stirs 1h, cold preservation 24h, the more described fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
13. 1 kinds of loose preparation methoies of wettability dysentery relieving as claimed in claim 3, is characterized in that, comprise the following steps:
A) take respectively the raw material of following weight portion:
B) described Realgar, described Talcum, described suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get described cyclodextrin and mix with water, be heated to 50 ℃, mix with described estragole, constant temperature stirs 1h, cold preservation 24h, the more described fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
14. 1 kinds of loose preparation methoies of wettability dysentery relieving as claimed in claim 4, is characterized in that, comprise the following steps:
A) take respectively the raw material of following weight portion:
B) described Realgar, described Talcum, described suspending agent are mixed, be crushed to 625 order～6250 object fine powders;
C) get described cyclodextrin and mix with water, be heated to 50 ℃, mix with described estragole, constant temperature stirs 1h, cold preservation 24h, the more described fine powder of preparing with step b) mixes, 40 ℃～50 ℃ are dried, pack and get final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720737A (en) * | 2014-01-24 | 2014-04-16 | 成都乾坤动物药业有限公司 | Traditional Chinese medicinal composition, preparation thereof, as well as preparation method and application of preparation |
| CN104706728A (en) * | 2015-03-23 | 2015-06-17 | 四川成康动物药业有限公司 | Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof |
| CN108283661A (en) * | 2018-04-26 | 2018-07-17 | 广州白云山宝神动物保健品有限公司 | A kind of Antidiarrheal powder for veterinary use suspension and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406701A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Normal-temperature preparation method of ultramicro antidysenteric powder and special bidirectional airflow screening machine thereof |
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2013
- 2013-10-31 CN CN201310530949.8A patent/CN103520267A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406701A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Normal-temperature preparation method of ultramicro antidysenteric powder and special bidirectional airflow screening machine thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720737A (en) * | 2014-01-24 | 2014-04-16 | 成都乾坤动物药业有限公司 | Traditional Chinese medicinal composition, preparation thereof, as well as preparation method and application of preparation |
| CN104706728A (en) * | 2015-03-23 | 2015-06-17 | 四川成康动物药业有限公司 | Combinatorial medicament used for treating piglet intestinal infection and preparation method thereof |
| CN108283661A (en) * | 2018-04-26 | 2018-07-17 | 广州白云山宝神动物保健品有限公司 | A kind of Antidiarrheal powder for veterinary use suspension and preparation method thereof |
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Application publication date: 20140122 |