RU2294196C2 - Curative-fodder additive and method for its application in case of parasitosis in animals - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with preparations and method for treating parasitosis in animals. The suggested curative-fodder additive contains, weight%: univerm 0.5-1.0; albendasol 0.05-0.1; fodder filler as concentrated feedstuffs and water - the rest. Water should be introduced into the additive to achieve 25-30% moisture of the mixture. While carrying out antiparasitic treatments animals should be fed with an antiparasitic preparation in its granulated preparative form in the dosages of 1.5-7.0 g/kg body weight, once for 3 d. Application of the present innovation enables to increase therapeutic efficiency and widen action range of antiparasitic treatments in animals.

EFFECT: higher efficiency.

3 cl, 6 ex, 5 tbl

Description

The invention relates to veterinary parasitology, and in particular to means and methods of treating animal parasitoses.

Known drugs and methods for group deworming of animals, including the giving of antiparasitic drugs - a department store or 10% albendazole - granulate mixed with loose concentrated feed or animal feed (Klenova I.F., Yaremenko N.A. Veterinary preparations in Russia, M., p. 172, p. 235).

However, the use of these drugs and methods has several disadvantages.

A department store that has a sharp unpleasant odor, when mixed with loose feed, is poorly eaten by animals, which leads to a decrease in therapeutic effectiveness due to the animals receiving an insufficient amount of the drug.

The therapeutic efficacy of albendazole against nematodes and cestodes in a dose recommended by the manufacturer (5 mg / kg for DV for sheep and 7.5 mg for cattle for DV) is not sufficient. Due to the use of this drug for a long time, the formation of albendazole-resistant helminth strains is not ruled out.

The disadvantage of using the department store and albendazole is the limited spectrum of their antiparasitic action. So, the department store does not have an anti-cestodic effect, and albendazole is not effective against ectoparasites. Therefore, additional deworming is necessary using anti-cestodic drugs, as well as drugs acting on pathogens of arachno-entomoses of animals. At the same time, the time and labor costs of veterinary specialists and workers increase.

The closest solution to the claimed invention, taken as a prototype, is feed-treatment granules with associated anthelmintics (tetramisole, phenasal) made on the basis of green mass of grass, hay, and the method of their use (M.Yu. Paskalskaya et al. Methodical recommendations. Preparation and use of therapeutic granular feeds with associated anthelmintics, Barnaul, 1980, p.2-6).

However, the preparation of medicinal feed pellets based on herbal flour has a seasonal confinement, also because of the presence of a natural food base in the summer, grass pellets are eaten worse by animals than in winter. Herbal flour granules have a solid consistency, which negatively affects their eatability by weakened or young animals. In addition, the preparation of granules does not include the composition of a department store and albendazole in their composition; the doses of these anthelmintics used in combination are not known.

The task of the invention is to expand the arsenal of antiparasitic drugs, increase the therapeutic effect of anthelmintics, improve the eatability of its antiparasitic drugs.

The technical problem is solved in that the animals are fed a medicinal feed additive containing anthelmintics and feed fillers according to the invention, characterized in that albendazole and a department are used as anthelmintics, concentrated feed, and additionally water taken in the following, are used as feed filler ratio, wt.%: department store - 0.5-1.0; albendazole 0.05-0.1; feed filler and water - the rest, and water is introduced into the additive to obtain 25-30% of the moisture content of the mixture.

The essence of the invention also lies in the fact that a medicinal feed additive is fed to animals at a dose of 1.5-7 g / kg of live weight, once for 3 days.

The essence of the invention also lies in the fact that the medicinal feed additive is fed to the animals in a granular formulation.

The work on the manufacture of a medicinal feed additive was carried out on a PShG-250 granulator equipped with control and measuring equipment and start-up protection devices. The composition of the antiparasitic agent includes 0.2% powder of the department store, 99% albendazole powder, concentrated feed, water the rest. In the process of preparation, all the components included in the therapeutic feed additive were dosed and administered sequentially using the method of stepwise approach to a given volume or portion of feed adopted for cooking. In this case, the entire dose of the drug substance was initially introduced into the same dose of the excipient and thoroughly mixed. Then, filler was added in portions with constant stirring. Water was added until a mixture of 25-30% was obtained. Having mixed the mixture twice, it was placed in a granulator dispenser. In the unit, under the action of a metering mixer, the mixture was brought to a homogeneous state and fed into the hopper of the granulator. Moving along the screw path, the mixture was heated, its state of aggregation changed. In the last section of the screw, the mixture, passing through the matrix filters, was formed into granules. Subsequently, after drying to a moisture content of 12-13%, the medicinal feed additive was packaged in bags and stored in a ventilated warehouse. In this dosage form, the active substances are distributed evenly, the granules are not hygroscopic and are well stored.

The invention is illustrated by the following examples.

Example 1. Components per 1 kg of granules — 0.2% department store powder 5 g, 99% albendazole powder 0.5 g were thoroughly mixed, and then feed additives — concentrated feed and water — were introduced in small portions while constantly mixing the mixture. . Water was added until a mixture of 25-30% was obtained. Stirring the mixture, it was placed in a granulator dispenser. In the unit, under the action of a metering mixer, the mixture was brought to a homogeneous state and fed to a loading funnel. When heated in the last section of the screw, the mixture, passing through the matrix filters, was formed into granules. Then the granules were dried to a moisture content of 12-13% and packaged in bags.

Example 2. Components per 1 kg of granules — 0.2% department store powder 10 g, 99% albendazole powder 1 g were mixed, and then feed additives — concentrated feed and water — were introduced in small portions, constantly mixing. Water was added until a mixture of 25-30% moisture was obtained. Subsequent operations are performed analogously to example 1.

Example 3. Determination of therapeutic efficacy of a therapeutic feed additive for moniesiosis and nematodoses of sheep was carried out on spontaneously invasive animals.

Lambs of 8 months of age were selected on the basis of analogues and experimental and control groups of animals were formed. Before setting up the experiment and 10 days after feeding the medicinal feed additive, ovoscopic examination of feces samples was carried out according to Kotelnikov-Khrenov (1974). In the experimental groups were included those animals in the samples of which moniesia eggs were found and strictil the gastrointestinal tract. The feed supplement in granular form was fed to experimental animals in the morning at a dose of 1.5-7 g / kg body weight, once for 3 days (groups 1, 3). Control animals received no antiparasitic agent (group 2, 4). The calculation of the effectiveness of the preparations was carried out according to the generally accepted technique (Nepoklonov, Talanov, 1966).

The results of the test of the effectiveness of the medicinal feed additive for moniesiosis and strongylitis of sheep are presented in table 1.

Table 1 No. p / p Group Number of animals EI after processing,% EE,% IE,% Effectiveness in Strongilosis one Experimental group 5 0 one hundred one hundred 2 Control group 3 one hundred 0 0 Cestodose efficacy 3 Experimental group 5 0 one hundred one hundred four Control group 3 one hundred 0 0

In animals, after feeding, there were no visible signs of intoxication. According to coprological studies, before the introduction of the granules, the infection of the sheep with intestinal strongilates and moniesia was 100% with an average number (SC) of 193 and 124 ind. eggs in 1 g of feces, respectively.

10 days after feeding the medicinal feed supplement, the results of ovoscopy of fecal samples of experimental animals gave a negative result, which indicates 100% of its therapeutic effectiveness (Table 1).

Example 4. The determination of the effectiveness of the medicinal feed additives taken in granular formulations was carried out under production conditions at 228 sheep producers in the Altai experimental farm in the village of Mukhor-Cherga.

Before the experiment, the infection of sheep with strongilates of the gastrointestinal tract was 100%, nematodirams 65% and moniesia 40% with an average number of eggs per gram of feces 1124, 89 and 350.4 ind. respectively. The feed supplement in granular formulations was fed to experimental animals in the morning at a dose of 1.5-7 g / kg live weight, once for 3 days. The results of coprological studies before the experiment and 10 days after feeding are presented in table 2.

table 2 Household Dates taken. samples Gr. wx Number of samples EI,% EI,% Nematodes Cestodes St Nem Tr Mon Before the introduction of the feed supplement village Mukhor-Cherga Oct Rams twenty one hundred one hundred 65 - 40 After the introduction of a medicinal feed additive village Mukhor-Cherga Oct Rams twenty twenty twenty 0 0 0

10 days after feeding the antiparasitic mixture, the infection of sheep with intestinal strongilates decreased to 20% with an average egg number of 8.4 specimens. in 1 g of feces. Nematodir and moniesia eggs were not found in samples of sheep feces. Extensibility for sheep intestinal strictile infections was 80%, IE - 99.3%, with nematodirosis and moniesiosis, the efficiency was 100%. (Table 3).

Table 3 Group Number of samples EI,% EE,% IE,% Efficacy of a feed supplement for strongilatosis Experimental animals twenty twenty 80 80 The control twenty one hundred 0 0 The effectiveness of a medicinal feed additive for moniesiosis Experimental animals twenty 0 one hundred one hundred The control twenty 40 0 0

Example 5. To assess the effectiveness of the medicinal feed additive for estrosis, sheep were infected with larvae — 80 specimens per lamb. The feed-feed supplement in granular formulations was fed in the morning feeding at the rate of 1.5-7 g / kg body weight, once for 3 days.

20 days after feeding the feed supplement, the animals were killed and examined. During the examination, the head of the sheep was freed from the skin, a skull was cut along the sagittal line, the lower and upper nasal passages, the labyrinth of the ethmoid bone, frontal sinuses and subthigh spaces were examined. On examination, the number of larvae was noted. Larvae were fixed and stored in bottles with 70 degrees. ethyl alcohol.

The results of studies to determine the therapeutic efficacy of a medicinal feed additive for sheep estrosis are presented in Table 4. No visible signs of intoxication were found in animals after feeding, the main physiological parameters (temperature, pulse, respiration) remained within the normal range. A pathological examination revealed no visible changes in the internal organs.

Table 4 №№ pp Group Number of animals EI,% AND ABOUT EE,% IE,% one Experimental 5 0 0 one hundred one hundred 2 Control 5 one hundred 31.2 - -

From table 4 it can be seen that all experimental animals were free from larvae, control ones were infected by 100.0%, with an average number of 31.2 larvae.

Example 6. The test of therapeutic efficacy of a medicinal feed additive for nematodes of maral was carried out on spontaneously infested young animals aged 1-1.5 years. Before processing, we performed coproscopic studies (coproovoscopy and coprolarvoscopy). Invasion of animals by larvae of the gastrointestinal tract and elafostrongilus larvae was 80% and 100%, respectively. The feed supplement in granular formulations was fed to experimental animals in the morning at a dose of 1.5-7 g / kg live weight, once for 3 days. Efficiency analysis was carried out according to the results of coproscopic studies 15 days after treatment.

In the course of the experiment, it was found that the eatability of the medicinal feed additive in experimental animals was satisfactory. In animals, after feeding, there were no visible signs of intoxication. The results of studies to determine the therapeutic efficacy of a medicinal feed additive for maral nematodoses are presented in table 5. After giving the medicinal feed additive in fecal samples obtained from the maral of the experimental group, eggs and larvae of the digestive system were not detected. Extensibility and intensification in case of strongilatoses of the gastrointestinal tract of marals was 100%, with elafostrongilosis these indicators were 83% and 86.3%, respectively.

Table 5. No. Group Qty EI% Midrange eggs / larvae in grams of feces EE% IE% Intestinal Strongilatoses one Experimental 70 0 0 one hundred one hundred 2 Control 70 77.9 143 - - Elafostrongilez 3 Experimental 70 17 16 83 86.33 four Control 70 one hundred 350 - -

Therefore, the proposed therapeutic feed additive and the method of its use in animal parasitoses has a high therapeutic effect, reduces the frequency of antiparasitic treatments, which reduces labor costs. The method allows to improve the eatability of drugs with a pungent odor (for example, a department store) due to the content of feed components in the granules that have undergone heat treatment, as well as due to the optimal ratio of the amount of active substance and feed ingredients in the mixture, and also increases the manufacturability of antiparasitic treatments.

Claims (3)

1. Medical and feed additive, including anthelmintics and feed fillers, characterized in that albendazole and a department are used as anthelmintics, concentrated feeds and additional water are used as feed filler in the following ratio, wt.%: Department store 0.5-1.0 Albendazole 0.05-0.1 Feed Filler and Water Rest moreover, water is added to the additive to obtain a 25-30% moisture content of the mixture. 2. A method of feeding a medicinal feed additive for animal parasitosis, characterized in that as a medicinal feed additive feed the medicinal feed additive according to claim 1 in doses of 1.5-7 g / kg m once, for 3 days. 3. The method according to claim 2, characterized in that the feed additive is fed in a granular formulation.