RU2406486C1 - Antiparasitic and mode of administration thereof treating bovine helminthiasis - Google Patents

Abstract

FIELD: medicine, veterinary science.

SUBSTANCE: invention concerns veterinary. An antiparasitic contains the ingredients taken in the ratio, wt %: univerm - 0.5-1.0; fascocid - 2.0-4.0; filler - the rest. The method consists in feeding said agent to bovine animals in a single dose 2.5-5.0 g/kg of body weight. The combined administration of anthelmintic agents acting on helminths of various systematic groups, expands an action spectrum of the preparation and allows to reduce frequency rate of antiparasitic treatment.

EFFECT: optimum relation of the active materials and feed ingredients allows higher technological effectiveness of antiparasitic actions of profitability increased by 20-25 %.

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Description

The invention relates to veterinary parasitology, and in particular to methods for treating animal parasitoses.

Known drugs and methods for deworming animals, including the cessation of antiparasitic drugs - a department store or fascocide mixed with loose concentrated feed or animal feed (Bespalova N.S. Modern antiparasitic drugs in veterinary medicine. - M .: KolosS, 2006. - 165 p., Karmaliev R . S. Anthelmintic efficacy of new dosage forms for cattle helminthiases / Karmaliev R.S. Rakhmetov A.I., Aytuganov B.E. // Tr. VIGIS. - 2006. - V. 43. - p. 115-120 .).

However, the use of these drugs and methods has several disadvantages.

The disadvantages of using the department store and fascocide in these dosage forms is the limitation of the spectrum of their antiparasitic action. So, the department store is not active against trematodes, and fascoscide is not effective for nematodoses. Therefore, additional deworming is necessary. At the same time, the time and labor costs of veterinary specialists increase.

The disadvantages of using fascocide and the department by free feeding in a mixture with feeds are also an increase in the time required to prepare the mixture, as well as a decrease in the therapeutic effectiveness of the preparations due to their uneven distribution in the mixture and insufficient intake of anthelmintics in the animal. In addition, a department store with a pungent unpleasant odor is poorly eaten by animals when mixed with bulk feed.

The closest solution to the claimed invention, taken as a prototype, is a medicinal feed additive containing anthelmintics albendazole and a department store, as well as feed fillers — concentrated feed and additionally water, taken in the following ratio, wt.%: Department store - 0.5-1.0; albendazole 0.05-0.1; feed filler and water - the rest, and water is introduced into the additive to obtain 25-30% of the moisture content of the mixture. (RF patent for the invention No. 2294196 of 02.27.2007).

However, the use of this therapeutic feed additive and method has disadvantages.

Although albendazole is used in this medicinal feed supplement, although it has a trematocidal effect, it is not effective enough against this group of parasites.

The objectives of the invention are to expand the arsenal of antiparasitic drugs that reduce the frequency of antiparasitic treatments of animals as a result of the combined use of anthelmintics of trematocidal and nematicidal action.

The problem is solved by the fact that an antiparasitic agent for the treatment of helminthiases in cattle, including anthelmintics and feed filler, according to the invention, as anthelmintics are used chamomile and department, in the following ratio (wt.%): Department store - 0.5-1.0; chamomile - 2.0-4.0 and feed filler - the rest.

The problem is also solved by the fact that in the method of treating helminthiases of cattle, including feeding an antiparasitic agent, according to the invention, an antiparasitic agent is fed, consisting of a fascist, a department store and a feed filler in the ratio (wt.%): Department store - 0.5-1.0; chamomile - 2.0-4.0 and feed filler - the rest, at a dose of 2.5-5.0 g / kg of animal weight, once.

The dose and frequency of use of the active substances that make up the antiparasitic agent are taken according to the instructions specified by the manufacturer (Klenova I.F., Yaremenko N.A. Veterinary preparations in Russia, M., 2000, p. 235; Kuzmin A. A. Anthelmintics in veterinary medicine. K., 2004, p.111).

Work on the manufacture of antiparasitic feed pellets was carried out on a PShG-250 granulator equipped with control and measuring equipment and start-up protection devices. The composition of the antiparasitic agent includes granules of fascocide, a department store, concentrated feed, water. During the preparation process, all the components included in the therapeutic feed additive were dosed and administered sequentially using the method of stepwise approaching a given volume or portion of feed adopted for cooking. In this case, the entire dose of the drug substance was initially introduced into the same dose of the excipient and thoroughly mixed. Then, filler was added in portions with constant stirring. Water was added until a mixture of 25-30% was obtained. Having mixed the mixture twice, it was placed in a granulator dispenser. In the aggregate, under the action of a metering mixer, the mixture was brought to a homogeneous state and fed into the hopper of the granulator. Moving along the screw path, the mixture was heated, its state of aggregation changed. In the last section of the screw, the mixture passing through the matrix filters was formed into granules. Subsequently, after drying to a moisture content of 12-13%, the medicinal feed additive was packaged in bags and stored in a ventilated warehouse. In this dosage form, the active substances are distributed evenly, the granules are not hygroscopic and are well stored.

The invention is illustrated by the following examples.

To work out the dose and frequency of use of the antiparasitic agent we proposed, we conducted a series of experiments.

Example 1. Determination of therapeutic efficacy of an antiparasitic agent at a dose of 1.5 g / kg m spent on cattle, spontaneously invaded by fascioli, paramphistomats and strongilata of the gastrointestinal tract in the SEC “Ynyrga” s. Enyrga of the Choysky region of the Altai Republic.

Before the experiment, the infection of animals with fascioli was 26.7%, paramphistomats - 13.3% and strongilates of the gastrointestinal tract 36.7% with an average number of eggs per gram of feces 2.0, 2.7 and 4.2 specimens, respectively. An antiparasitic agent was fed to experimental animals in the morning feeding at a dose of 1.5 g / kg of live weight, once. The results of coprological studies before the experiment and 30 days after feeding are presented in table 1.

Table 1 Household Group of animals Number of samples Sampling Dates EI,% EI,% trematodes nematodes Fasc Param Str SEC "Ynyrga" Milking herd thirty December (before processing) 56.7 26.7 13.3 36.7 SEC "Ynyrga" Milking herd thirty January (after processing) 10.0 3.3 6.7 0

30 days after feeding the antiparasitic agent, cattle infestation with fasciols and paramphistomats decreased to 3.3 and 6.7% with an average egg population of 1.0 and 2.0 specimens. in 1 g of feces, respectively. Eggs of intestinal strongilates in samples of animal feces were not found. Extensibility in cattle fascioliasis and paramphistomatosis was 94.0 and 75.0%, and IE - 74.0 and 61.0%, respectively. The effectiveness of the drug with strictilatosis of the gastrointestinal tract was 100% (table 2).

table 2 Group Number of samples EI,% EE,% IE,% Fascioliasis efficacy Experimental animals thirty 3.3 94.0 74.0 The control 10 20.0 - - Efficacy for paramphistomatosis Experimental animals thirty 10.0 75.0 61.0 The control 10 20.0 - - Effectiveness in Strongilosis Experimental animals thirty 0 100.0 100.0 The control 10 30.0 - -

Example 2. Determination of therapeutic efficacy of an antiparasitic agent at a dose of 2.5 g / kg m spent on cattle, spontaneously invaded by fascioli, paramphistomats and strongilata of the gastrointestinal tract in the SEC “Ynyrga” s. Enyrga of the Choysky region of the Altai Republic.

Before the experiment, the infection of animals with fascioli was 33.3%, paramphistomats - 16.7% and strongilates of the gastrointestinal tract 50.0% with an average number of eggs per gram of feces 1.7, 2.2 and 4.8 specimens, respectively. An antiparasitic agent was fed to experimental animals in the morning feeding at a dose of 2.5 g / kg body weight, once. The results of coprological studies before the experiment and 30 days after feeding are presented in table 3.

Table 3 Household Group of animals Number of samples Sampling Dates EI,% EI,% trematodes nematodes Fasc Param Str SEC "Ynyrga" Milking herd thirty December (before processing) 70.0 33.3 16.7 50.0 SEC "Ynyrga" Milking herd thirty January (after processing) 3.3 0 3.3 0

30 days after feeding the product, the infection of cattle with paramphistomats decreased to 3.3% with an average number of eggs of 1.0 specimen. in 1 g of feces. Fasciol and intestinal strongil eggs were not found in samples of animal feces. Extensivity for cattle paramphistomatosis was 90.0%, IE - 76.0%, with fascioliasis and strongylatosis, the efficiency was 100% (Table 4).

Table 4 Group Number of samples EI,% EE,% IE,% Fascioliasis efficacy Experimental animals thirty 0 100.0 100.0 The control 10 20.0 - - Efficacy for paramphistomatosis Experimental animals thirty 3.3 90.0 76.0 The control 10 20.0 - - Effectiveness in Strongilosis Experimental animals thirty 0 100.0 100.0 The control 10 30.0 - -

Example 3. Determination of therapeutic efficacy of an antiparasitic agent at a dose of 5.0 g / kg m spent on cattle, spontaneously invaded by fascioli, paramphistomats and strongilata of the gastrointestinal tract in the SEC “Ynyrga” s. Enyrga of the Choysky region of the Altai Republic.

Before the experiment, the infection of animals with fascioli was 36.7%, paramphistomats - 16.7% and strongilates of the gastrointestinal tract 53.3% with an average number of eggs per gram of feces 1.7, 2.8 and 5.2 specimens, respectively. An antiparasitic agent was fed to experimental animals in the morning feeding at a dose of 5.0 g / kg. m., once. The results of coprological studies before the experiment and 30 days after feeding are presented in table 5.

Table 5 Household Group of animals Number of samples Sampling Dates EI,% EI,% trematodes nematodes Fasc Param Str SEC "Ynyrga" Milking herd thirty December (before processing) 63.3 36.7 16.7 53.3 SEC "Ynyrga" Milking herd thirty January (after processing) 0 0 3.3 0

30 days after feeding the antiparasitic agent, the infection of cattle with paramphistomats decreased to 3.3% with an average number of eggs of 1.0 specimen. in 1 g of feces. Fasciol and intestinal strongil eggs were not found in samples of animal feces. Extensibility for cattle paramphistomatosis was 90.2%, IE - 81.0%, with fascioliasis and strongylatosis, the efficiency was 100% (Table 6).

Table 6 Group Number of samples EI,% EE,% IE,% Fascioliasis efficacy Experimental animals thirty 0 100.0 100.0 The control 10 20.0 - - Efficacy for paramphistomatosis Experimental animals thirty 0 90.2 81.0 The control 10 20.0 - - Effectiveness in Strongilosis Experimental animals thirty 0 100.0 100.0 The control 10 30.0 - -

Thus, it was found that the antiparasitic agent at a dose of 1.5 g / kg m. possesses trematocidal and nematicidal action, but with respect to trematodes it is not effective enough. The therapeutic efficacy of an antiparasitic agent in doses of 2.5-5.0 g / kg m.zh. in relation to fasciol, paramphistomat and strongilates of the gastrointestinal tract amounted to 100.0, 90.0-90.2 and 100.0%, respectively.

Thus, an antiparasitic agent containing chamomile and department as anthelmintic in doses of 1.5-5 g / kg m. effective against cattle helminths. However, the optimal doses of an antiparasitic drug in the treatment of cattle helminthiases are 2.5-5.0 g / kg m. (EE 90.0-100.0%).

Example 4. The determination of the comparative therapeutic efficacy of an antiparasitic agent containing chamomile and a university anthelmintic with a medicinal-feed supplement containing albendazole and a university (taken as a prototype) was carried out on cattle spontaneously invaded by fascioli, paramphistomats and strong gastrointestinal tracts in the SEC "Ynyrga" with. Enyrga of the Choysky region of the Altai Republic.

An experimental group of animals, the antiparasitic agent we offer, containing fascinosis and a department store, was fed in the morning feeding at a dose of 2.5 g / kg m. The control animals were given a medicinal feed supplement containing albendazole and a department at a dose of 3 g / kg m.

Ovoscopic studies of feces samples were carried out before the experiment and 30 days after deworming.

Prior to the experiment, the infection of animals in the experimental group by fascioli was 33.3%, by paramphistomats - 16.7% and by strongilates of the gastrointestinal tract 50.0% with an average number of eggs per gram of feces 1.7, 2.2 and 4.8 specimens, respectively. 30 days after feeding the product, the infection of cattle with paramphistomats decreased to 3.3% with an average number of eggs of 1.0 specimen. in 1 g of feces. Fasciol and intestinal strongil eggs were not found in samples of animal feces.

Infection of animals in the control group before the introduction of a medicinal feed additive containing albendazole and a department store was: fascioli - 15.0%, paramphistomats - 20.0% and strongilates of the gastrointestinal tract 35.0% with an average number of eggs in 1 g of feces 2.6, 3.1 and 5.0 specimens ., respectively. 30 days after feeding the feed supplement, cattle infestation with fasciols and paramphistomats decreased to 10.0 and 15.0% with an average egg population of 2.3 and 2.6 specimens. in 1 g of feces, respectively. Eggs of intestinal strongilates in samples of animal feces were not found.

The extensibility of our proposed antiparasitic agent containing fascinosis and a department for cattle paramphistomatosis was 90.0%, IE - 76.0%, and for fascioliasis and strongylatosis the efficiency was 100%.

The extensibility of a medicinal feed supplement containing albendazole and a department for fascioliasis and paramphistomatosis in cattle was 65.0 and 62.5%, and IE was 53.4 and 44.1%, respectively. The effectiveness of the medicinal feed additive for strictilatoses of the gastrointestinal tract was 100% (Table 7).

Table 7 No. Group Number of animals EI,% after processing EE,% IE,% Fascioliasis efficacy one Experimental group thirty 0 100.0 100.0 2 Control group twenty 10.0 65.0 53.4 Efficacy for paramphistomatosis one Experimental group thirty 3.3 90.0 76.0 2 Control group twenty 15.0 62.5 44.1 Effectiveness with Strongilatosis one Experimental group thirty 0 100.0 100.0 2 Control group twenty 0 100.0 100.0

The results of a comparative study of the two drugs showed that, with an equivalent nematicidal effect, the effectiveness of an antiparasitic drug containing fascocide and the department is 35–56% higher than the efficacy of the feed additive containing albendazole and the department with respect to trematodes.

The use of an antiparasitic agent containing fascocide and the university, compared with the feed supplement containing albendazole and the university (taken as a prototype), is more effective in treating cattle trematodoses. Thus, the method of combined use of a fascuside and a department store allows deworming of animals simultaneously against helminths of different systematic groups - trematodes and nematodes.

Giving an antiparasitic agent by free feeding is carried out in the usual feeding mode and does not require the use of additional methods of fixation and grouping of animals, which increases the manufacturability of antiparasitic treatments.

Claims (2)

1. Antiparasitic agent for the treatment of helminthiases in cattle, including anthelmintics and feed filler, characterized in that as anthelmintics are used chamomile and department, in the following ratio, wt.%: Department - 0.5-1.0; chamomile - 2.0-4.0 and feed filler - the rest. 2. A method for the treatment of helminthiases in cattle, including feeding an antiparasitic agent, characterized in that an antiparasitic agent is fed, consisting of a fascuside, a department store and a feed filler in a ratio, wt.%: Department store, 0.5-1.0; chamomile - 2.0-4.0 and feed filler - the rest, at a dose of 2.5-5.0 g / kg of animal weight, once.