MD1013Z - Method for treating arachnoenthomoses and nematodoses in piglets and calves - Google Patents
Method for treating arachnoenthomoses and nematodoses in piglets and calves Download PDFInfo
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- MD1013Z MD1013Z MDS20150140A MDS20150140A MD1013Z MD 1013 Z MD1013 Z MD 1013Z MD S20150140 A MDS20150140 A MD S20150140A MD S20150140 A MDS20150140 A MD S20150140A MD 1013 Z MD1013 Z MD 1013Z
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Abstract
Изобретение относится к ветеринарии, а именно к способу лечения арахноэнтомозов и нематодозов у поросят и телят.Способ, согласно изобретению, включает введение поросятам и телятам лечебного средства содержащего, в масс.%: препарат содержащий 20% аверсектина С - 1,08, препарат содержащий 40% лактулозы - 69,52 и полиэтиленгликоль 400 - 29,40, при этом лечебное средство вводят в дозе 0,1 мл на 1 кг массы тела, с сухим кормом, дважды с интервалом в 24 часа.The invention relates to veterinary medicine, and in particular to a method for the treatment of arachnoentomiasis and nematodoses in piglets and calves. The method according to the invention includes the administration to piglets and calves of a therapeutic agent containing, in wt.%: A preparation containing 20% aversectin C - 1.08, a preparation containing 40% of lactulose - 69.52 and polyethylene glycol 400 - 29.40, while the therapeutic agent is administered at a dose of 0.1 ml per 1 kg of body weight, with dry food, twice with an interval of 24 hours.
Description
Invenţia se referă la veterinărie, şi anume la un procedeu de tratare a arahnoentomozelor şi nematodozelor la purcei şi viţei. The invention relates to veterinary medicine, namely to a method for treating arachnoentomosis and nematodoses in piglets and calves.
Disbacterioza tractului gastro-intestinal al gazdei - una din principalele consecinţe ale dezvoltării nematodozelor la animale, se manifestă prin reducerea componenţei calitative şi cantitative a microflorei normale şi majorarea microflorei condiţionat patogene şi patogene. Dysbacteriosis of the host's gastrointestinal tract - one of the main consequences of the development of nematodoses in animals, is manifested by a reduction in the qualitative and quantitative composition of the normal microflora and an increase in conditionally pathogenic and pathogenic microflora.
Microflora (nepatogenă) normală a tractului digestiv, datorită particularităţilor enzimatice, sintetice şi altele, joacă un rol deosebit în procesele vitale ale organismului şi la protecţia lui, prin influenţa antagonistă a microflorei normale a intestinului în raport cu microorganismele patogene. Prin urmare, se poate menţiona că în cazul bolilor parazitare odată cu administrarea antihelminţilor se poate observa agravarea unor boli transmisibile şi netransmisibile (Якубовский М.В. Достижения и проблемы профилактики паразитозов. Ученые записки: сб. науч. тр. по материалам Международной научно-практической конференции «Актуальные проблемы ветеринарной медицины и зоотехнии», посвященной 80-летию основания УО ВГАВМ, 4-5 ноября 2004 года, Витебск, Министерство сельского хозяйства и продовольствия Республики Беларусь, Учреждение образования «Витебская государственная академия ветеринарной медицины». Витебск, 2004. Т. 40, ч. 1, p. 331-332) The normal (non-pathogenic) microflora of the digestive tract, due to its enzymatic, synthetic and other peculiarities, plays a special role in the vital processes of the body and in its protection, through the antagonistic influence of the normal intestinal microflora in relation to pathogenic microorganisms. Therefore, it can be mentioned that in the case of parasitic diseases, together with the administration of anthelmintics, the aggravation of some communicable and non-communicable diseases can be observed (Yakubovskii M.V. Достижения и проблымы прифлактики празитозов. Ученые записки: сб. науч. тр. по материал Международной научно-практической конферция «Актуальные пробымы ветеринарной медиционы и зоотехнии», просписанной 80-летию остановка УО ВГАВМ, 4-5 November 2004, Министерство сельского хозяйства Республики Беларусь, Учреждение образования «Витебская государственная ветеринальной медицины». Т. 40, p. 331-332)
În timpul de faţă există un număr destul de mare de preparate antiparazitare, având un spectru larg de acţiune. În acelaşi timp, multe dintre ele pot acţiona negativ asupra microflorei intestinale a animalului. Toate preparatele, în procesul acţiunii lor terapeutice, într-o măsură mai mare sau mai mică provoacă dezvoltarea sau agravarea disbacteriozei în organismul-gazdă. Currently, there is a fairly large number of antiparasitic drugs with a wide spectrum of action. At the same time, many of them can negatively affect the intestinal microflora of the animal. All drugs, in the process of their therapeutic action, to a greater or lesser extent provoke the development or aggravation of dysbacteriosis in the host organism.
De aceea orice procedeu de tratament al paraziţilor majorează sau împiedică normalizarea multor indici ai organismului animal, care au suferit modificări în procesul de parazitare a helminţilor. That is why any parasite treatment procedure increases or prevents the normalization of many indices of the animal's body, which have undergone changes in the process of helminth parasitism.
În particular, esenţial se micşorează normalizarea microflorei, se agravează starea generală a animalului bolnav, se lungeşte perioada afecţiunii, se majorează cheltuielile la tratarea animalului, iar aceasta, în cele din urmă, influenţează calitatea producţiei animale şi preţul de cost. In particular, the normalization of the microflora is significantly reduced, the general condition of the sick animal worsens, the period of the disease is prolonged, the costs of treating the animal increase, and this ultimately influences the quality of animal production and the cost price.
Aici este necesar de menţionat că o parte esenţială dintre preparatele antiparazitare de pe piaţa autohtonă reprezintă medicamente terapeutice de import, care de obicei sunt scumpe, ce esenţial creşte preţul de cost al producţiei animaliere. It is necessary to mention here that an essential part of the antiparasitic preparations on the domestic market are imported therapeutic drugs, which are usually expensive, which essentially increases the cost price of animal production.
În calitate de cea mai apropiată soluţie serveşte procedeul de tratare a arahnoentomozelor şi nematodozelor cu utilizarea preparatului „Univerm”, care conţine în calitate de substanţă cu acţiune activă aversectin C, în cantitate de 0,2% [1]. The closest solution is the treatment of arachnoentomosis and nematodoses using the preparation "Univerm", which contains aversectin C as the active substance in an amount of 0.2% [1].
Acest preparat posedă un spectru larg de acţiune împotriva nematodozelor şi arahnoentomozelor la animale cornute mari, ovine, suine, iepuri (Стасюкевич С.И. Современные аспекты борьбы с паразитическими членистоногими. Ученые записки учреждения образования «Витебская государственная академия ветеринарной медицины»: Научно-практический журнал. Витебск, 2011. Т. 47, вып. 2, ч. 1, p. 99-101., Ятусевич А.И. Эффективность препаратов авермектинового комплекса при паразитозах сельскохозяйственных животных. Ветеринарные и зооинженерные проблемы в животноводстве и научно-методическое обеспечение учебного процесса: Материалы II международной научно-практической конференции. Минск, 1997, p. 220-222). This preparation has a wide spectrum of action against nematodes and arachnoentomoses in large horned animals, sheep, pigs, rabbits (Stasyukevich S.I. Sovremennye aspekts bolshes s paraziticheskimi chlenistonogimi. Ученые записки беходящие образования «Витебская государственная академия ветеринариной медицины": Научно-практический журнал. Витебск, 2011. Т. 47, вып. 2, ч. 1, p. 99-101., Ятусевич А.И. Еффективность празратив авермектиного комплекса при паразитозах золожейского животных.
Dezavantajul acestui procedeu constă în aceea că la fel ca toţi antihelminţii, aversectin C manifestă o acţiune negativă asupra microflorei tractului gastro-intestinal. The disadvantage of this process is that, like all anthelmintics, aversectin C has a negative effect on the microflora of the gastrointestinal tract.
Problema pe care o rezolvă invenţia propusă constă în elaborarea unui nou procedeu de tratare a arahnoentomozelor şi nematodozelor la purcei şi viţei cu utilizarea unui remediu antiparazitar complex, care posedă un efect atât terapeutic pronunţat, cât şi profilactic al disbacteriozei, stimulează dezvoltarea normală a microflorei tractului gastro-intestinal şi preîntâmpină influenţa negativă a antihelminţilor asupra microflorei tractului gastro-intestinal al animalelor. The problem solved by the proposed invention consists in developing a new method for treating arachnoentomosis and nematodoses in piglets and calves using a complex antiparasitic remedy, which has both a pronounced therapeutic and prophylactic effect on dysbacteriosis, stimulates the normal development of the microflora of the gastrointestinal tract and prevents the negative influence of anthelmintics on the microflora of the gastrointestinal tract of animals.
Invenţia soluţionează problema prin aceea că se propune un procedeu de tratare a arahnoentomozelor şi nematodozelor la purcei şi viţei, care include administrarea unui remediu ce conţine, în % masă: preparat conţinând 20% de aversectin C - 1,08, preparat conţinând 40% de lactuloză - 69,52 şi polietilenglicol 400 - 29,40, totodată remediul se administrează în doză de 0,1 ml la 1 kg de greutate corporală, cu hrana uscată, de două ori cu un interval de 24 ore. The invention solves the problem by proposing a method for treating arachnoentomosis and nematodoses in piglets and calves, which includes administering a remedy containing, in % mass: preparation containing 20% aversectin C - 1.08, preparation containing 40% lactulose - 69.52 and polyethylene glycol 400 - 29.40, at the same time the remedy is administered in a dose of 0.1 ml per 1 kg of body weight, with dry food, twice with an interval of 24 hours.
Procedeul are următoarele avantaje. The process has the following advantages.
În primul rând, momentul esenţial în caracteristica prebioticelor este componenţa lor, care asigură stimularea reprezentanţilor microflorei intestinale utile pentru organism, precum sunt bifidobactriile şi lactobacilii. First of all, the essential moment in the characteristic of prebiotics is their composition, which ensures the stimulation of representatives of the intestinal microflora useful for the body, such as bifidobacteria and lactobacilli.
În al doilea rând, prin stimularea microorganismelor benefice, se inhibă agenţii patogeni şi se creează microfloră favorabilă, nu numai în stomac, dar şi în intestin. Secondly, by stimulating beneficial microorganisms, pathogens are inhibited and favorable microflora is created, not only in the stomach, but also in the intestine.
În al treilea rând, prebioticele contribuie la absorbţia de către organism a vitaminelor, macro- şi microelementelor, şi activizează sistemul imunitar. Thirdly, prebiotics contribute to the body's absorption of vitamins, macro- and microelements, and activate the immune system.
Proprietăţile farmacologice ale remediului ţin de proprietăţile componentelor sale individuale: The pharmacological properties of the remedy depend on the properties of its individual components:
Aversectin C, substanţă pentru producerea preparatelor utilizate în medicina veterinară (aversectin C 20%, ТУ 9383-009-17266133-97 НПЦ «Фармбиомед», Rusia sau СТО 17266133-0003-2012, ООО «Фармбиомедсервис», Rusia), se obţine în baza produselor metabolice ale ciupercii de sol Streptomyces avermitilis. Aversectin C, a substance for the production of preparations used in veterinary medicine (aversectin C 20%, TU 9383-009-17266133-97 NPC «Farmbiomed», Russia or СТО 17266133-0003-2012, OOO «Farmbiomedservis», Russia), is obtained based on the metabolic products of the soil fungus Streptomyces avermitilis.
Aversectin C sporeşte producţia inhibitorului neurotransmiţător al acidului gamma butiric, care serveşte pentru a transmite semnale de la celulele nervoase la celulele musculare, blocând astfel trecerea impulsurilor nervoase care cauzează paralizia şi moartea parazitului (Allen Dana G. Handbook of veterinary drugs. 3 rd. ed. USA, 2005. 1111 p.; Bishop Y. The veterinary formulary. Sixth edition. Great Britain, 2005. 566 p). Aversectin C increases the production of the neurotransmitter inhibitor gamma butyric acid, which serves to transmit signals from nerve cells to muscle cells, thus blocking the passage of nerve impulses that cause paralysis and death of the parasite (Allen Dana G. Handbook of veterinary drugs. 3 rd. ed. USA, 2005. 1111 p.; Bishop Y. The veterinary formulary. Sixth edition. Great Britain, 2005. 566 p.).
Lactuloza - izomer chimic al lactozei, este o dizaharidă sintetică formată din galactoză şi fructoză. Această dizaharidă nu se găseşte în natură. Mecanismul său de acţiune este următorul: fiind un carbohidrat nefermentabil, lactuloza neschimbată ajunge cu uşurinţă în intestinul gros, unde sub influenţa dizaharidazelor microflorei zaharolitice se hidrolizează până la monozaharide şi, în cele din urmă, până la catene scurte ale acizilor carboxilici seria alifatică, astfel, pH-ul la nivelul intestinului gros este deplasat spre partea acidă. În aceste condiţii o mare parte a amoniacului se află sub formă ionizată (NH4+), care este slab absorbită în sânge şi excretată din organism, pe când mediul alcalin sporeşte formarea amoniacului în formă neionizată (NH3), care este bine absorbită în sânge. Lactulose - a chemical isomer of lactose, is a synthetic disaccharide formed from galactose and fructose. This disaccharide is not found in nature. Its mechanism of action is as follows: being a non-fermentable carbohydrate, unchanged lactulose easily reaches the large intestine, where under the influence of disaccharidases of saccharolytic microflora it is hydrolyzed to monosaccharides and, finally, to short chains of carboxylic acids of the aliphatic series, thus, the pH in the large intestine is shifted towards the acidic side. Under these conditions, a large part of the ammonia is in the ionized form (NH4+), which is poorly absorbed into the blood and excreted from the body, while the alkaline environment enhances the formation of ammonia in the unionized form (NH3), which is well absorbed into the blood.
Polietilenglicol-400 (PEG-400) - un stabilizator care îmbunătăţeşte biodisponibilitatea substanţei medicamentoase prin ameliorarea dizolvării sale. PEG-400 are o capacitate sporită de dizolvare în ceea ce priveşte substanţele cu caracter hidrofil şi hidrofob şi poate fi folosit ca o bază eficace la crearea medicamentelor. Are proprietăţi de agent tensioactiv şi capacitate de emulsionare (Aulton E. Michael. Aulton's pharmaceutics. The design and manufacture of medicines. 3 rd. ed. Hungary:Churchill Livingstone Elsevier, 2007, 717 p.) Polyethylene glycol-400 (PEG-400) - a stabilizer that improves the bioavailability of the drug substance by improving its dissolution. PEG-400 has an increased dissolution capacity for hydrophilic and hydrophobic substances and can be used as an effective base for creating drugs. It has surfactant properties and emulsifying capacity (Aulton E. Michael. Aulton's pharmaceutics. The design and manufacture of medicines. 3 rd. ed. Hungary:Churchill Livingstone Elsevier, 2007, 717 p.)
Rezultatul tehnic al invenţiei constă în aceea că procedeul de tratare a arahnoentomozelor şi nematodozelor posedă nu numai un efect puternic terapeutic, dar şi profilactic evoluţionist al disbacteriozei, stimulează dezvoltarea normală a microflorei tractului gastro-intestinal şi preîntâmpină influenţa negativă a antihelminţilor asupra acesteia. The technical result of the invention consists in the fact that the method of treating arachnoentomosis and nematodoses possesses not only a strong therapeutic effect, but also an evolutionary prophylactic effect of dysbacteriosis, stimulates the normal development of the microflora of the gastrointestinal tract and prevents the negative influence of anthelmintics on it.
Procesul de preparare a remediului se realizează prin amestecarea ingredientelor. The process of preparing the remedy is carried out by mixing the ingredients.
Eficienţa procedeului a fost confirmată în condiţii de producţie. The efficiency of the process was confirmed under production conditions.
Exemple de realizare a invenţiei Examples of embodiments of the invention
Exemplul 1 Example 1
A fost efectuată o experienţă de producţie cu 150 de purcei de 2,5…4,0 luni. La examenul coproscopic s-a constatat prezenţa unei invazii asociate, inclusiv ascarida de porc, esofagita în raport diferit. A production experiment was conducted with 150 piglets aged 2.5…4.0 months. Coproscopic examination revealed the presence of an associated invasion, including pork ascaris, esophagitis in varying proportions.
Clinic invazia s-a manifestat prin inhibarea animalelor cu alternarea crizelor de excitaţie, precum şi prin lipsa sau diminuarea poftei de mâncare, încălcarea actului de defecare (creşterea frecvenţei de defecare, diluarea fecalelor, prezenţa particulelor de furaj nedigerat). Clinically, the invasion was manifested by inhibition of the animals with alternating bouts of excitement, as well as by lack or decrease in appetite, violation of the act of defecation (increased frequency of defecation, dilution of feces, presence of undigested feed particles).
În baza studiului microbiologic al fecalelor porcilor infestaţi, s-a constatat că numărul de bifidobacterii şi lactobacili este redus semnificativ, în special la animalele infestate cu 3 sau mai multe specii de paraziţi (până la 105…106 UFC/cm3), în timp ce microflora tranzitorie (micromicete, bacili aerobici) creşte până la 105…106 UFC/cm3, sunt prezente bacterii lactozo-negative, care indică dezvoltarea disbacteriozei tractului gastro-intestinal. Based on the microbiological study of feces of infected pigs, it was found that the number of bifidobacteria and lactobacilli is significantly reduced, especially in animals infested with 3 or more species of parasites (up to 105…106 CFU/cm3), while the transient microflora (micromycetes, aerobic bacilli) increases to 105…106 CFU/cm3, lactose-negative bacteria are present, which indicates the development of dysbacteriosis of the gastrointestinal tract.
Animalele infestate au fost împărţite în două loturi, câte 75 capete în lot. Animalele neinfestate (30 capete) au fost incluse în lotul martor. The infested animals were divided into two groups, 75 animals per group. The non-infested animals (30 animals) were included in the control group.
Purceilor din primul lot experimental cu scop terapeutic li s-a administrat remediul antiparazitar complex în doză de 0,1 ml la 1 kg de greutate corporală, cu hrana uscată, în jumătatea normei unei alimentaţii, de două ori, cu un interval de 24 ore. The piglets in the first experimental batch for therapeutic purposes were administered the complex antiparasitic remedy at a dose of 0.1 ml per 1 kg of body weight, with dry food, in half the norm of a diet, twice, with an interval of 24 hours.
Animalele din lotul doi au fost tratate cu preparatul antiparazitar "Univerm" în conformitate cu instrucţiunea. The animals in the second batch were treated with the antiparasitic preparation "Univerm" according to the instructions.
Drept criterii de evaluare a eficacităţii terapeutice a helmintozei şi profilactice a disbacteriozei au servit semnele clinice şi de laborator privind prezenţa paraziţilor şi a disbateriozei (inclusiv coproscopic şi cercetări microbiologice), precum şi sporul mediu zilnic în greutate. The criteria for evaluating the therapeutic efficacy of helminthiasis and the prophylactic efficacy of dysbacteriosis were clinical and laboratory signs of the presence of parasites and dysbacteriosis (including coproscopic and microbiological research), as well as the average daily weight gain.
La efectuarea cercetărilor s-a luat în considerare procentul de animale eliberate de helminţi într-o perioadă de 7 zile, precum şi prezenţa indicilor clinici şi microbiologici, specifici disbacteriozei şi perioada în care aceştea au încetat să se înregistreze. When conducting the research, the percentage of animals freed from helminths over a 7-day period was taken into account, as well as the presence of clinical and microbiological indices specific to dysbacteriosis and the period in which they ceased to be recorded.
În urma cercetărilor s-a constatat că eficacitatea terapeutică maximală s-a menţionat la primul lot experimental, fiind de 99,2%, în al doilea lot experimental ("Univerm") - 98,7%. Sporul mediu zilnic maximal al masei corporale a animalelor din lotul I a fost de 107 g, în acelaşi timp, în lotul II experimental acest indice a constituit 98 g. As a result of the research, it was found that the maximum therapeutic efficacy was noted in the first experimental group, being 99.2%, in the second experimental group ("Univerm") - 98.7%. The maximum average daily increase in body weight of animals in the first group was 107 g, at the same time, in the second experimental group this index was 98 g.
Animalele nu prezentau semne clinice de disbacterioză, după tratamentul conform procedeului propus nu s-a înrăutăţit starea clinică şi componenţa microorganismelor tractului gastro-intestinal, fapt ce demonstrează eficacitatea profilactică a procedeului împotriva disbacteriozei tractului gastro-intestinal. The animals did not show clinical signs of dysbacteriosis, after treatment according to the proposed procedure, the clinical condition and the composition of the gastrointestinal tract microorganisms did not worsen, which demonstrates the prophylactic efficacy of the procedure against gastrointestinal tract dysbacteriosis.
Exemplul 2 Example 2
Eficienţa procedeului de tratare a arahnoentomozelor şi nematodozelor s-a studiat în condiţii de producţie pe 200 capete de viţei, în vârstă de 4,5…6,0 luni. La cercetările coproscopice s-a constatat prezenţa strongiloidozei, în timp ce la 24 viţei această invazie se prezintă în acosiere cu Ostertagia, Bunostomum spp. şi esofagita în raport diferit. The efficiency of the treatment procedure for arachnoentomosis and nematodoses was studied under production conditions on 200 calves, aged 4.5…6.0 months. Coproscopic research revealed the presence of strongyloidiasis, while in 24 calves this invasion was present in association with Ostertagia, Bunostomum spp. and esophagitis in different ratios.
Clinic invazia s-a manifestat prin inhibarea animalelor cu alternarea crizelor de excitaţie, precum şi prin lipsa sau diminuarea poftei de mâncare, încălcarea actului de defecare (creşterea frecvenţei de defecare, diluarea fecalelor, prezenţa particulelor de furaj nedigerat). Clinically, the invasion was manifested by inhibition of the animals with alternating bouts of excitement, as well as by lack or decrease in appetite, violation of the act of defecation (increased frequency of defecation, dilution of feces, presence of undigested feed particles).
Cercetările microbiologice ale fecalelor viţeilor infestaţi au demonstrat că numărul de bifidobacterii şi lactobacili s-a redus semnificativ, în special la animalele cu invazie asociată (la 105…107 UFC/cm3), în acelaşi timp microflora tranzitorie (micromicetele, bacilii aerobici) creşte până la 105…106 UFC/cm3, sunt prezente bacteriile lactozo-negative, care indică dezvoltarea disbacteriozei tractului gastro-intestinal. Microbiological research on the feces of infected calves has shown that the number of bifidobacteria and lactobacilli has significantly reduced, especially in animals with associated invasion (to 105…107 CFU/cm3), at the same time the transient microflora (micromycetes, aerobic bacilli) increases to 105…106 CFU/cm3, lactose-negative bacteria are present, which indicates the development of dysbacteriosis of the gastrointestinal tract.
Animalele infestate au fost împărţite în două loturi, câte 100 de capete în lot. Animalele neinfestate (30 capete) au constituit lotul martor. Pentru viţeii din primul lot experimental a fost folosit remediul antiparazitar complex pentru tratarea şi profilaxia arahnoentomozelor şi nematodozelor într-o doză de 0,1 ml per 1 kg de greutate corporală, cu hrana uscată, în jumătatea normei unei alimentaţii, de două ori, la un interval de 24 ore; al doilea lot de animale au fost tratate cu preparatul antiparazitar "Univerm" în conformitate cu instrucţiunea. The infested animals were divided into two groups, 100 heads per group. The uninfested animals (30 heads) constituted the control group. For the calves in the first experimental group, the complex antiparasitic remedy for the treatment and prophylaxis of arachnoentomosis and nematodoses was used in a dose of 0.1 ml per 1 kg of body weight, with dry food, in half the norm of one feeding, twice, at an interval of 24 hours; the second group of animals was treated with the antiparasitic preparation "Univerm" according to the instructions.
Drept criterii de evaluare a eficacităţii terapeutice a helmintozei şi a eficacităţii profilactice a disbacteriozei au servit semnele clinice şi de laborator privind prezenţa paraziţilor şi a disbacteriozei (inclusiv cercetările coproscopice microbiologice), precum şi sporul mediu zilnic în greutate. În cercetările efectuate s-a luat în considerare procentul de animale care s-au eliberat de helminţi în perioada de 14 zile, precum şi prezenţa indicilor inerent clinici şi a parametrilor microbiologici specifici disbacteriozei şi perioada în care aceştia au încetat să se înregistreze. The criteria for evaluating the therapeutic efficacy of helminthiasis and the prophylactic efficacy of dysbacteriosis were clinical and laboratory signs of the presence of parasites and dysbacteriosis (including microbiological coproscopic research), as well as the average daily weight gain. The research took into account the percentage of animals that were freed from helminths during the 14-day period, as well as the presence of inherent clinical indicators and microbiological parameters specific to dysbacteriosis and the period in which they ceased to be recorded.
Rezultatele cercetărilor au demonstrat că eficacitatea terapeutică maximă s-a observat în primul lot experimental şi a constituit 98,4%, în al doilea lot experimental ("Univerm") - 98,0%. Sporul mediu zilnic maximal a fost la animalele din lotul I, care a constituit 564 g, în acelaşi timp la al doilea lot experimental acest indice a fost de 498 g. Animalele nu prezentau semne clinice de disbacterioză, după tratamentul conform procedeului propus nu au schimbat statutul clinic şi compoziţia microorganismelor tractului gastro-intestinal, ceea ce demonstrează eficacitatea profilactică a procedeului împotriva disbacteriozei tractului gastro-intestinal. The results of the research showed that the maximum therapeutic efficacy was observed in the first experimental group and amounted to 98.4%, in the second experimental group ("Univerm") - 98.0%. The maximum average daily gain was in the animals of the first group, which amounted to 564 g, while in the second experimental group this index was 498 g. The animals did not show clinical signs of dysbacteriosis, after treatment according to the proposed procedure they did not change the clinical status and composition of microorganisms of the gastrointestinal tract, which demonstrates the prophylactic efficacy of the procedure against dysbacteriosis of the gastrointestinal tract.
Aşadar, la utilizarea procedeului propus se obţine un efect terapeutic pronunţat contra helmintozelor, dar şi profilactic al disbacteriozei, se stimulează dezvoltarea microflorei normale a tractului gastro-intestinal şi se previne impactul negativ al deparazitării asupra florei normale a tractului gastro-intestinal al animalelor. Therefore, when using the proposed process, a pronounced therapeutic effect is obtained against helminthiasis, but also prophylactic against dysbacteriosis, the development of the normal microflora of the gastrointestinal tract is stimulated and the negative impact of deparasitization on the normal flora of the gastrointestinal tract of animals is prevented.
1. Субботина И.А. Универм, как эффективное средство при неоскариозе крупного рогатого скота. XI Международная научно-производственная конференция. Белгород, 14-18.05.2007 1. Subbotina I.А. Univerm, as an effective remedy for neoscariosis of large-horned cattle. XI International scientific-production conference. Belgorod, 14-18.05.2007
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