MD80Y - Method of prophylaxis and treatment of parasitoses to cattle - Google Patents

Abstract

The invention relates to parasitology, in particular to a method for the prophylaxis and treatment of parasitosis in cattle and can be used in veterinary medicine. The method includes diagnosis, administration of appropriate antiparasitic preparations, determination of the type of reactivity of animals to stress with the establishment of stress-reactive and stress-resistant animals, determination of the level of infestation in stress-reactive animals and repeated administration of antiparasitic preparations to infested animals over 14 days. The result of the invention consists in increasing the therapeutic effect in the prophylaxis and treatment of parasitosis in cattle.

Description

[0001] The invention relates to parasitology, in particular to a method for the prophylaxis and treatment of parasitosis in cattle and can be used in veterinary medicine.

[0002] In animals, after establishing the parasitological diagnosis, the appropriate method of treatment is applied. For example, in case of illness of animals with fasciolosis (agent - Fasciola hepatica), the diagnosis is established on the basis of coprological analyses and detection of eggs of this parasite, which are eliminated in the external environment with feces. For the treatment of the disease, antiparasitic preparations (from the entire arsenal of preparations) are selected, which are indicated in this disease and have the greatest effectiveness [1].

[0003] The result of deworming animals depends on a number of factors, but in principle, on the quality of the preparation applied.

[0004] It has been found that the same animals, of the same age, kept under the same conditions, have a different intensity of invasion. It is also established that in the treatment and prophylaxis of parasitic diseases, infested animals react differently to the action of the antiparasitic preparation administered against the same invasion.

[0005] The animal organism is constantly influenced by a number of stress factors of the external environment. The level of stress resistance, which is the type of higher nervous reactivity, has a decisive influence on the reactivity and adaptation capacity of the animal organism to stress factors. Currently, this factor is not taken into account when applying methods of prophylaxis and treatment of parasitosis in animals.

[0006] The problem solved by the invention consists in increasing the effectiveness of the process of prophylaxis and treatment of parasitosis in cattle.

[0007] The problem is solved by the fact that the method of prophylaxis and treatment of parasitosis in cattle includes the diagnosis and administration of appropriate antiparasitic preparations. Additionally, the type of reactivity of cattle to stress is determined with the establishment of stress-reactive and stress-resistant animals, after the administration of antiparasitic preparations to stress-reactive animals, the level of infestation is determined and in the case of infestation of animals over 14 days, antiparasitic preparations are administered to them repeatedly.

[0008] The result of the invention consists in increasing the therapeutic effect in the prophylaxis and treatment of parasitic diseases in cattle.

[0009] The method allows to select cattle resistant to infestation with various parasitic agents and to increase the effectiveness of the treatment of parasitosis. The method is not expensive and does not require a large amount of work, since the procedures for determining the intensity and extent of the invasion after the administration of antiparasitic preparations to stress-resistant cattle and their repeated deworming are excluded, while it is taken into account that the effectiveness of the treatment is different and depends on the type of stress reactivity of the animals. Therefore, the degree of infestation of cattle with parasites after the administration of antiparasitic preparations to stress-reactive cattle is determined more accurately, which allows to increase the therapeutic effect by their repeated deworming.

[0010] Consequently, a direct correlation is found between the type of stress reactivity and the level of parasite infestation, as well as the effectiveness of treatment and prophylaxis of parasitic diseases.

[0011] To demonstrate the effectiveness of the proposed method, a series of experiments were carried out in production.

[0012] The experiments were carried out in the period 1997-2002 in the Laboratory of Parasitology and Helminthology of the Institute of Zoology of the Academy of Medical Sciences and at the farm in the village of Colonita, Chisinau municipality. The research aimed to determine the effectiveness of the processes of prophylaxis and treatment of parasitosis in cattle with different types of reactivity. The preparations used in the experiment (Ivomec, Valbazen, Brovitacoccid) are registered and recommended for the treatment of animals in the Republic of Moldova.

[0013] After determining the type of stress reactivity, according to the adrenaline method formulated by Ahmadiev G.M. (Adrenaline test for assessing individual animal sensitivity to stress factors. News of agricultural sciences of Kazakhstan, 1990, No. 12, p. 86-87), adult cattle were divided into 2 groups: group I - stress-reactive, group II - stress-resistant. 60 adult cattle were selected for the study, 30 each in groups I and II. Both groups of adult cattle were divided into 3 groups, each of 10 animals. Before applying antiparasitic preparations to cattle, the extent of invasion (EI) and the intensity of invasion (II) were determined. Group 1 includes cattle treated with Brovitacoccid (1 g per 10 kg live weight for 5 days, orally), a coccidiostatic preparation, which has therapeutic efficacy against eimeria (Eimeria spp.); group 2 - cattle treated with Ivomec (1 ml 1% solution per 50 kg live weight, subcutaneously on the side of the neck), an antiparasitic preparation, which has therapeutic efficacy against nematodes (Strongyloides papillosus) and group 3 - treated with Valbazen (10% suspension, 10 ml per 100 kg live weight, orally), an antiparasitic preparation, which has therapeutic efficacy against trematodes (Fasciola hepatica, Dicrocelium lanceolatum).

Example 1

[0015] Coprological research of adult cattle from group I (stress-reactive) until antiparasitic treatment demonstrated the following results of invasion extensity (EI) and invasion intensity (II):

[0016] group 1: Eimeria spp. - 100%, II - 4...20 oocysts;

[0017] group 2: S. papillosus - 80%, II - 8...28 larvae;

[0018] group 3: F. hepatica - 50%, II - 8…12 eggs; D. lanceolatum - 70%, II - 8…18 eggs.

[0019] The results of the coprological research of adult cattle from the second batch (stress-resistant) were as follows:

[0020] group 1: Eimeria spp. - 50%, II - 4...8 oocysts,

[0021] group 2: S. papillosus - 40%, II - 8...28 larvae,

[0022] group 3: F. hepatica - 20%, II - 3…5 eggs; D. lanceolatum - 40%, II - 4…6 eggs.

The results are presented in Table 1.

[0024] Table 1

[0025] Infestation level of adult cattle prior to antiparasitic treatment

Parasite species

Group I (stress-reactive)

Batch II (stress-resistant)

Group 1

Group 2

Group 3

Group 1

Group 2

Group 3

THEY,

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

F. hepatica

-

-

-

-

50

8…12

-

-

-

-

20

3…5

D. lanceolatum

-

-

-

-

70

8…18

-

-

-

-

40

4…6

S. papillosus

-

-

80

8…18

-

-

-

-

40

6…8

-

-

Eimeria spp.

100

4…10

-

-

-

-

50

4…8

-

-

-

-

[0027] After establishing the invasion, the administration of antiparasitic preparations to cattle is carried out in both batches.

[0028] Group 1 includes cattle treated with Brovitacoccid (1 g per 10 kg live weight for 5 days, orally), group 2 - cattle treated with Ivomec (1 ml 1% solution per 50 kg live weight, subcutaneously on the side of the neck), and group 3 - treated with Valbazen (10% suspension, 10 ml per 100 kg live weight, orally). In group I (stress-reactive) after treatment, their infestation level was determined, in which parasitic forms were established:

[0029] group 1 - it was established that 20% of cattle were infested with Eimeria spp., II - 3…12 oocysts,

[0030] group 2 - 10% of cattle infested with S. papillosus were detected, II - 3 larvae,

[0031] group 3 - 20% of cattle were found to be infested with F. hepatica, II - 3…4 eggs and 30% infested with D. lanceolatum, II - 4…8 specimens.

[0032] To confirm the dependence of the effectiveness of antiparasitic preparations on the type of stress reactivity, in the second group (stress-resistant) after treatment, their infestation level was determined (only in the experiment).

[0033] After the antiparasitic treatment, in the adult cattle of the second group (stress-resistant) parasitic agents did not establish. Therefore, in the stress-resistant animals it is not necessary to determine the level of infestation after the application of the antiparasitic treatment and they do not require repeated deworming.

The results are presented in Table 2.

[0035] Table 2

[0036] Infestation level of adult cattle after antiparasitic treatment

Parasite species

Group I (stress-reactive)

Batch II (stress-resistant)

Group 1

Group 2

Group 3

Group 1

Group 2

Group 3

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

F. hepatica

-

-

-

-

10

3

-

-

-

-

0

0

D. lanceolatum

-

-

-

-

20

2…3

-

-

-

-

0

0

S. papillosus

-

-

10

3

-

-

-

-

0

0

-

-

Eimeria spp.

20

3…12

-

-

-

-

0

0

-

-

-

-

[0038] Therefore, the obtained results show that the effectiveness of treatment with antiparasitic preparations in the therapy of parasitic diseases was different and determined by the type of reactivity of animals to stress. It was lower in cattle from the stress-reactive group: by 12.5% in those infested with S. papillosus, by 20% - Eimeria spp., by 40% - F. hepatica and by 42.8% - in those infested with D. lanceolatum. In adult cattle from the stress-resistant group, parasitic agents were not established.

[0039] Therefore, the results obtained indicate a direct correlation between the type of stress reactivity and the level of parasite infestation, as well as the effectiveness of treatment and prophylaxis of parasitosis.

[0040] Cattle from group I (stress-reactive) that were infested were dewormed repeatedly over 14 days: group 1 - with Brovitacoccid (1 g per 10 kg live weight over 5 days), group 2 - with Ivomec (1 ml 1% solution per 50 kg live weight) and group 3 - with Valbazen (10% suspension, 10 ml per 100 kg live weight). After the second administration of the antiparasitic preparations, a therapeutic efficacy of 100% was determined in all groups. The results are presented in table 3.

[0041] Table 3

[0042] Infestation level of adult cattle after repeated antiparasitic treatment

Parasite species

Group I (stress-reactive)

Group 1

Group 2

Group 3

EI, %

II, ex.

EI, %

II, ex.

EI, %

II, ex.

F. hepatica

-

-

-

-

0

0

D. lanceolatum

-

-

-

-

0

0

S. papillosus

-

-

0

0

-

-

Eimeria spp.

0

0

-

-

-

-

[0044] Thus, when determining the effectiveness of antiparasitic treatment in cattle, it is recommended to take into account the type of reactivity of the animals to stress, and in reactive animals, in order to achieve high effectiveness of the antiparasitic treatment, it is necessary to apply repeated treatment to the infested ones. Therefore, in stress-resistant animals, it is not necessary to determine the level of infestation after applying the antiparasitic treatment and it is not necessary to deworm them repeatedly, because a direct correlation has been found between the type of reactivity to stress and the level of infestation with parasites, as well as the effectiveness of the treatment and prophylaxis of parasitosis.

[0045] 1. Demidov N.V. Helminthosis of animals. Moscow, Agropromizdat, 1987, p. 113-116

Claims (1)

1. Method for the prophylaxis and treatment of parasitosis in cattle, which includes the diagnosis and administration of appropriate antiparasitic preparations, characterized in that the type of reactivity of cattle to stress is additionally determined with the establishment of stress-reactive and stress-resistant animals, after the administration of antiparasitic preparations to stress-reactive animals, the level of infestation is determined and in the case of infestation of animals over 14 days, antiparasitic preparations are administered to them repeatedly