JP2017008012A - Solid oral agents for administering to fishes, feed for fish breeding containing agents concerned, and methods of administering agents to fish - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide oral administration agents for fishes which can overcome the damage to a fish body caused by the hydrogen peroxide water treatment of the prior art and the economic disadvantage by stopping feeding, and additionally can alleviate or inhibit the decrease in the intake amount of fish due to medicinal ingredients, such as praziquantel; and to provide feed for fish breeding containing the same.SOLUTION: The present invention provides a solid oral administration agent for fishes formed by a method comprising granulating a mixture containing a medical ingredient such as praziquantel, carbon powders, and additionally a binder by an extruder; and feed for fish breeding containing the same.SELECTED DRAWING: None

Description

  The present invention relates to a solid orally administered drug for fish formed by a method comprising a step of granulating a mixture containing a medicinal ingredient and carbon powder. Furthermore, the present invention provides a method for producing the solid fish orally administered medicine, a fish feed containing the solid fish orally administered medicine, a method of administering the medicine to fish using the fish feed, and The present invention relates to a method for preventing and / or treating fish diseases.

  In fish farming, pathogenic bacteria and parasites can invade from outside the ginger that is cultivating fish. Therefore, it is necessary to always consider the prevention and treatment of fish diseases caused by these. For example, in the cultivation of yellowtail and amberjack, parasitism (Benedenia seriolae) is a major problem. As a method for exterminating damselfly from a fish body, the fish body is treated with fresh water or hydrogen peroxide water for a certain period of time. However, these treatments have a problem that the fish body is loaded. Specifically, in the present work of removing damselfly with hydrogen peroxide solution, the ginger is surrounded by a waterproof sheet to block the ginger from the outside seawater, and the hydrogen peroxide solution is put into the seawater inside the sheet. When a predetermined amount is added and the fish such as amberjack attached to the fish is immersed for about 5 to 10 minutes to swim, the beetle attached to the fish such as amberjack will be damaged and fall off from the fish body. There is a problem that the fish body, such as, also suffers health damage. In order to reduce the damage to the fish body due to the hydrogen peroxide treatment, generally, the bait is stopped for two days in total on the day before and on the day of the medicine bath. In a period when there is a lot of hadamushi extermination work (July to November), it may be necessary to carry out this hydrogen peroxide treatment once a week, and stop feeding for two days every week, that is, 20% of the total number of days. There is a problem that the growth of the fish body is delayed by stopping the bait for a period of ˜40%. In particular, since July to November is also the water temperature environment in which amberjack grows most, it is a time when it is desired to feed as much feed as possible, and this delay in the growth of the fish body is a serious problem. In addition, there is a problem that the hydrogen peroxide treatment must be performed while paying attention to the safety of aquaculture workers.

  As a technique for overcoming such various problems, there is a technique for eliminating the damselfly by adding orally administering to the fish such as yellowtail, amberjack etc. It has been developed (Non-Patent Document 1). It has been reported that this plaziquantel can not only eliminate the damselfly, but also can eliminate the intracranial fluke (Schistosoma japonicum) (patent document 1, non-patent document 2) and the fish parasite, such as trough pufferfish (Heterobothium okamotoi). (Patent Document 2). Non-Patent Document 2 reports that Praziquantel was effective in vitro at a concentration of 0.2 ppm against bluefin tuna intravascular fluke. However, praziquantel has properties that are unknown to the cause, but it has the property that it is extremely reluctant to take fish orally, and the feed intake of praziquantel is reduced, resulting in inadequate efficacy. Since the growth of fish bodies slows down, simply adding Praziquantel to fish feed and ingesting the fish spontaneously orally is problematic in terms of the economics of aquaculture. On the other hand, to avoid this decrease in food intake, it may be possible to forcibly administer Praziquantel to fish, but it is impossible to forcibly orally administer to a large number of fish at the actual aquaculture site. It is. In addition, it is presumed that it is also effective to control Hadamushi by using Prajiquater dissolved in seawater (Non-Patent Document 1), but there is too much necessary amount of Praziquantel for use in normal fish farming. This is not possible at the farming site.

  In general, charcoal such as activated carbon is known to have a property of adsorbing various substances, for example, a mixture formed from praziquantel, activated carbon and colloidal silicon dioxide may mask the bitterness of praziquantel. It has been reported (Patent Document 3). Further, Patent Document 4 discloses an animal solid feed in which a drug is spread on the surface of the solid feed by using an animal feed spreading agent containing carbon powder. Furthermore, Patent Document 5 discloses a fish parasite-controlling agent containing a salicylanilide-based drug, and a feed containing this control agent by coating it in the case of fish sensitive to the taste and smell of this control agent. It has been suggested to prevent a decrease in palatability. However, the present inventor made a moist pellet for fish farming by mixing powder plastic quantel, carbon powder, and raw materials for fish farming, and examined the palatability of this feed over amberjack. As shown by way of example, it was confirmed that the decrease in palatability of fish moist pellets due to the incorporation of Praziquantel was not improved by simply incorporating the carbon powder. Therefore, although the masking of the bitterness of Praziquantel by carbon powder has been confirmed in humans as shown in Patent Document 3, the technique shown in Patent Document 3 has not been effective in overcoming the decrease in preference for fish. .

In fish farming, especially from June to November when the water temperature is high, various kinds of diseases of cultured fish, such as nodules and streptococci, hadamushi and streptococci, aphids and nocardiosis, endovascular fluke and There is a tendency for nodular diseases to occur simultaneously and frequently. In such a case, in order to treat a plurality of simultaneously occurring diseases at the same time, it is necessary to administer a plurality of types of medicinal ingredients to the cultured fish. There are many medicinal properties having poor properties (for example, in addition to praziquantel, erythromycin, oxytetracycline hydrochloride, florfenicol, thiamphenicol, sulfamonomethoxine sodium (Dimeton ^{(registered trademark)} soda)), sulfizol sodium (Islan ^{(Registered trademark)} soda)), and when a feed containing a medicinal ingredient is orally administered to fish, if at least one medicinal ingredient with poor palatability is included, it is consumed due to the medicinal ingredient with poor palatability. There was also a problem that the amount of food was reduced, and as a result, the effects of other medicinal ingredients were insufficient. Thus, until now, it has been difficult to treat such complex diseases at once.

JP 2012-162524 A Japanese Patent Laid-Open No. 11-60485 JP 2007-523108 A JP 2006-340622 A International Publication No. 2012/002379

Kinetics research 2000.8. No. 60, pages 1 to 12 “Oral Administration Type Fish Parasite Control Agent“ Hadaclean ” Kazuo Ogawa, Grants-in-Aid for Scientific Research (Scientific Grants-in-Aid for Scientific Research) Research Report, March 31, 2013, “Basic Research for Countermeasures against Bluefin Tuna Schistosomiasis” [online] [June 2015 Search on 18th] (https://kaken.nii.ac.jp/pdf/2012/seika/C-19_1/72645/22380105seika.pdf)

  Therefore, in the cultivation of fish such as yellowtail and amberjack, even if a medicinal ingredient such as praziquantel is added to fish feed such as moist pellets and dry pellets, the reduction in food intake caused by this medicinal ingredient is reduced. Although development of a fish feed containing medicinal ingredients that can be controlled and can fully exert its medicinal effects in fish, and can be produced inexpensively and easily without the need for complicated techniques, it has not been realized for many years. It was.

  The present inventors have conducted intensive studies on a medicinal ingredient-containing fish feed that can solve the above-mentioned problems. As a result, the solid form formed by a method including a step of granulating a mixture containing the medicinal ingredient and carbon powder. In particular, a fish feed containing a solid orally administered drug for fish formed by a method including a step of pressurizing and extruding granulation of a mixture containing a medicinal ingredient, carbon powder and a binder is extremely I found it useful. In other words, even if the medicinal component itself contained in this fish feed is low in preference to fish like Praziquantel, it is possible to reduce or suppress the decrease in food intake caused by this medicinal component and to be effective Therefore, the present inventors have found that the above-described problems in hydrogen peroxide treatment can be solved without impairing the economics of fish culture, and the present invention has been completed based on this.

The present invention provides a solid fish orally administered drug formed by a method comprising the step of granulating a mixture containing a medicinal ingredient and carbon powder.
The present invention also provides the solid orally administered medicine for fish, wherein the mixture containing a medicinal ingredient and carbon powder further contains a binder.
In addition, the present invention provides the solid orally administered medicine for fish, wherein the step of granulating the mixture is a step of pressurizing the mixture and extruding it.
In addition, the present invention provides the solid orally administered medicine for fish, wherein the step of pressurizing the mixture and extruding and granulating is performed in an extruder.
The present invention also provides the solid fish orally administered drug for fish, wherein the solid fish orally administered drug has a swollen structure.
In addition, the present invention provides the solid orally administered medicine for fish that has adsorbed fats and oils.
In addition, the present invention provides the solid orally administered drug for fish, wherein the medicinal component contains praziquantel.
The present invention also provides a fish feed comprising the solid orally administered drug for fish.
Moreover, this invention provides the said feed for fish farming whose said feed for fish farming is a moist pellet or an extruder pellet.
Moreover, this invention provides the method of administering a chemical | medical agent to fish by making fish ingest the said feed for fish farming.
The present invention also provides a method for preventing and / or treating fish diseases by allowing fish to feed the feed for fish farming.
The present invention also provides a method for producing a solid orally administered drug for fish, comprising the step of granulating a mixture comprising a medicinal ingredient and carbon powder.

  The solid orally administered drug for fish of the present invention is a case where the medicinal component itself contained in the drug has low palatability for fish, such as Praziquantel, when used as a fish feed containing the same. However, the reduction in food intake caused by this medicinal ingredient can be reduced or suppressed, and sufficient medicinal effect can be exerted. Therefore, a medicinal ingredient such as Praziquantel, which is a conventional technique, is simply added to fish feed. When administered, it has an advantageous effect that it does not cause deterioration in the economics of aquaculture. This effect was particularly remarkable in a solid orally administered drug for fish formed by a method including a step of pressing a mixture containing a medicinal ingredient, carbon powder and a binder in an extruder and extruding granulation. The solid orally administered medicine for fish of the present invention has a high hardness compared with that granulated without containing carbon powder, so that it is easy to handle and creates a fish feed containing the medicine. At the same time, there is an advantageous effect that the solid state of the drug is difficult to collapse. In addition, when the drug is a solid drug in which fats and oils are adsorbed, for example, when a fish feed is prepared, it is relatively easy to receive a physical impact in which frozen raw food is stirred together with the solid drug. Even under such conditions, there is an advantageous effect that the disintegration of the solid drug can be reduced and suppressed. Furthermore, in the aspect in which the fats and oils are adsorbed, the adsorbed fats and oils themselves have an effect of suppressing the release of the medicinal component from the solid drug. There is an advantageous effect that it is possible to further suppress a decrease in the amount of food intake due to the release of the medicinal component from the medicinal agent, which can be prominent when the amount of the medicinal component contained in the solid medicinal agent increases. In addition, in the conventional hydrogen peroxide treatment, surrounding the ginger with a waterproof sheet, a predetermined amount of hydrogen peroxide solution is put into the seawater inside the sheet, and yellowtails such as beetles attached to parasites, It is possible to eliminate the labor-intensive operation of removing this sheet after immersing fish such as amberjack for a certain period of time, and eliminating damage to the fish body caused by this hydrogen peroxide solution treatment, and is generally used for hydrogen peroxide solution treatment. It is economically advantageous in fish farming, and the aquaculture worker can also avoid the danger of hydrogen peroxide water. There are also advantageous effects. That is, according to the present invention, in the cultivation of fish, the parasite, in particular, the chemical bathing operation with hydrogen peroxide water for the control work of damselfish is basically unnecessary, and therefore, the aquaculture operation itself is revolutionarily improved. This is an invention.

The microscopic observation result of the cross section of the solid orally administered medicine for fishes of this invention (manufacture example 3) which has a swelling structure is illustrated. The microscopic observation result of the cross section of the solid medicine for oral administration for fish which has the swelling structure of comparative manufacture example 3 granulated without using carbon powder is illustrated.

One aspect of the present invention is a solid orally administered medicine for fish formed by a method comprising a step of granulating a mixture containing a medicinal ingredient and carbon powder. In the present invention, the medicinal component is not particularly limited as long as it is a medicinal component that prevents and / or treats fish diseases, and examples thereof include antibiotics, synthetic antibacterial agents and anthelmintic agents. For example, praziquantel, salicylanilide series drugs, ivermectin, erythromycin, oxytetracycline, florfenicol, thianphenicol, ampicillin, oxophosphate, sulfamonomethoxine sodium (Dimeton ^{(registered trademark)} soda), And sulfizole sodium (Islan ^{(registered trademark)} soda). Further, the medicinal component contained in the solid orally administered drug for fish of the present invention may be not only one type but also plural types, and examples of the plural types include a combination containing praziquantel and oxyclozanide. It is not limited to this. Even if it is a medicinal component with poor fish taste, when it is contained in fish feed and orally administered, it is effective as a medicinal component from the viewpoint of reducing or suppressing the decrease in spontaneous feeding of fish. Preferably, the medicinal component itself is a substance with low fish taste, such as praziquantel, erythromycin, oxytetracycline hydrochloride, florfenicol, thianphenicol, sodium sulfamonomethoxine ⁽ Daimeton ^{(registered trademark)} soda), And Rufizole sodium (Islan ^{(registered trademark)} soda). More preferably, the medicinal component includes praziquantel. In the present invention, a commercially available product (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) can be used as Praziquantel.

  In the present invention, the carbon powder may be derived from an arbitrary substance, for example, prepared by powdering any charcoal such as charcoal such as Bincho charcoal, black charcoal, coconut husk charcoal, coffee charcoal, bamboo charcoal, activated charcoal, etc. be able to. The size of the carbon powder is not particularly limited as long as it does not violate the object of the present invention, but preferably the size of passing 10 mesh or more, more preferably the size of passing 50 mesh or more, More preferably, the carbon powder has a size that passes 100 mesh or more.

  The mixture used for producing the solid pharmaceutical preparation for oral administration of fish of the present invention may contain a binder in addition to the medicinal component and the carbon powder. When the method for forming a solid orally administered drug for fish of the present invention includes a step of pressurizing the raw material mixture and extrusion granulation, the raw material mixture preferably contains a binder. One preferable aspect of the present invention is a solid orally administered drug for fish formed by a method including a step of pressing and extruding granulation of a mixture containing a medicinal ingredient, carbon powder and a binder. The binder is not particularly limited as long as it can form a solid orally administered drug for fish. Examples of binders include various starches obtained from wheat flour, rice flour, soybean cake, gluten, rice, corn, potato, sweet potato, pregelatinized starch, sodium alginate, sodium caseinate, sodium carboxymethylcellulose, propylene glycol, sodium polyacrylate , Lignic acid, inorganic substances such as calcium carbonate, talc, bentonite, and fats and oils such as fats and oils that are solid at room temperature, such as palm fats and oils, but not limited thereto. Preferably, the binder includes various starches and pregelatinized starches obtained from wheat flour, rice flour, soybean meal, gluten, rice, corn, potato, sweet potato and the like. More preferably, examples of the binder include starch and pregelatinized starch.

  A mixture containing a medicinal ingredient, carbon powder and optionally a binder used for producing the solid fish pharmaceutical for oral administration according to the present invention is an excipient, water, oil or fat unless it is contrary to the object of the present invention. Any other material such as may also be included. Examples of the excipient include lactose, starch, calcium carbonate, talc, bentonite and the like, but are not particularly limited. The proportion of each component in this mixture is not particularly limited as long as it can form a solid orally administered drug and does not contradict the purpose of the present invention, for example, 1 to 50% by weight of a medicinal component, Contains 2-50 wt% carbon powder and 10-90 wt% excipient. In addition, the mixture containing the medicinal component, carbon powder and binder in another embodiment of the present invention is also made of any other material such as water, fats and oils, for example, palm fats and oils, unless it is contrary to the purpose of the present invention. May be included. The proportion of each component in this mixture is not particularly limited as long as it can form a solid orally administered drug and does not contradict the purpose of the present invention, for example, 1 to 50% by weight of a medicinal component, It contains 2 to 50% by weight of carbon powder and 5 to 90% by weight of binder, preferably 2 to 30% by weight of medicinal components, 5 to 50% by weight of carbon powder, and 10 to 70% by weight of binder.

  In one aspect, the solid orally administered drug for fish of the present invention is formed by a method comprising the step of granulating a mixture comprising a medicinal ingredient and carbon powder. The granulating step is not particularly limited as long as a solid molded body can be formed from this mixture. For example, pressure using an extruder, extrusion granulating step, pellet machine, pellets Examples include a dry pellet forming process using a mill, a granulating process using a cylindrical granulator, a wet extrusion granulator, a tableting molding process using a tableting machine, a tablet machine, and the like. The pellet machine and pellet mill may be an apparatus used to produce ordinary dry pellet feed, and the operating conditions thereof can also form a solid molded body, as long as it does not contradict the purpose of the present invention. May be normal operating conditions and is not particularly limited. Moreover, a tableting machine and a tablet machine will not be specifically limited with the operating conditions, if a normal tablet can be formed.

  Preferably, the “step of granulating the mixture” in the present invention is a step of pressurizing and extruding the mixture of the raw materials. In this embodiment, the device used to form the solid fish orally administered drug of the present invention is a device capable of pressurizing and extruding the mixture of the raw materials, that is, pressurizing the mixture and There is no particular limitation as long as it is an apparatus that can form a solid molded body by extrusion. For example, an extruder, a pellet machine, a pellet mill, etc. are mentioned from a viewpoint that these series of processes can be easily performed with one apparatus. Preferably, in the present invention, the step of pressurizing and extruding the mixture of the raw materials, more preferably the mixture containing the medicinal ingredients, the carbon powder and the binder, is performed in an extruder, and more preferably performed in a twin-screw extruder. Is called. The extruder may be an apparatus as used to produce ordinary extruder pellet feed, and its operating conditions can also form a solid molded body, as long as it does not contradict the purpose of the present invention. It may be normal operating conditions and is not particularly limited. The pressure at the time of pressurization in the present invention is appropriately set depending on the apparatus to be used, the material to be used, the intended degree of swelling, the size of the drug to be formed, the heating temperature, etc. Is 0.1 to 7.0 atmospheres, preferably 0.5 to 6.5 atmospheres. Typically, it is preferred that the mixture is heated during pressurization. For example, when an extruder is used, the barrel temperature of the extruder is preferably 70 to 130 ° C. In the extruder, water such as water vapor is added to the mixture of the above raw materials, in particular, the raw material mixture containing a binder such as starch, and the mixture is kneaded by applying heat and pressure stepwise by the rotation of a screw. Water and air contained in the mixture swell by discharging while releasing the pressure from the hole of the die to a lower pressure environment, for example, to an atmospheric pressure environment. It is possible to have an expanded structure with bubbles.

  The solid orally administered drug for fish of the present invention may or may not have an expanded structure. In the present invention, the expanded structure is a structure in which bubbles are formed inside a solid molded body. The expanded structure is contained in the mixture by, for example, discharging the mixture under high pressure from a hole such as a die while releasing the pressure in a lower pressure environment, for example, an atmospheric pressure environment in an extruder or the like. It can be formed by the expansion of the water or air and the generation of bubbles in the solid molded body. In one aspect, preferably, the solid pharmaceutical preparation for oral administration of fish of the present invention has a swollen structure.

  In another embodiment, the solid orally administered drug for fish of the present invention may not have an expanded structure. In this case, during the production, granulation is performed under such a condition that the mixture containing the medicinal component and the carbon powder does not expand. For example, when a mixture containing a medicinal component and carbon powder is granulated by a dry pellet forming step, the obtained molded body generally does not have an expanded structure. Moreover, when the mixture containing a medicinal ingredient and carbon powder is granulated by tableting, the obtained molded body generally does not have an expanded structure. Even when an extruder is used, a solid orally administered drug for fish that does not have a swollen structure can be produced by pressurizing and extruding granulation under conditions such that the mixture does not swell.

  In the present invention, the solid molded body formed by granulation may be subjected to further arbitrary treatment. In particular, since the solid molded body formed by pressurization and extrusion granulation as described above may contain moisture, it may be subjected to further arbitrary treatment such as a drying treatment thereafter. In the case where it is desired that the solid fish oral administration drug is dried from the viewpoint of ease of handling and the like, the solid fish oral administration drug of the present invention is, for example, added after granulation. After the pressure and extrusion granulation, it is preferably subjected to a drying treatment. When drying is unnecessary, a solid molded body formed by granulation may be used as a raw material for fish feed.

  The term “solid” in the solid oral administration medicine for fish of the present invention means that the mixture of components constituting the medicine has an integrated shape, that is, an integrated molded body. This is a distinction from the state in which the mixture of the components does not form an integrated shape. For example, when each component exists as a so-called powdery mixture, it does not fall under the “solid state” in the present invention. Further, the “solid state” in the present invention may be a granular shape, a tablet shape, a pellet shape, and the like, and various shapes such as a spherical shape, a substantially spherical shape, an ellipsoidal shape, a substantially elliptical shape, a cylindrical shape, and a substantially cylindrical shape. Examples include, but are not limited to, shapes. Moreover, the solid orally administered drug for fish of the present invention may be a mixture of two or more types of molded articles having different shapes. Moreover, the size of the solid orally administered drug for fish according to the present invention may be any size suitable for blending into a fish feed, such as the size of the fish to which the feed is administered, the shape of the fish feed, etc. Typically, in the case of a sphere and a substantially sphere, the diameter is 0.2 mm to 20 mm, more typically, the diameter is 0.5 mm to 12 mm, More typically, the diameter may be 1 mm to 8 mm. In the case of a cylindrical shape and a substantially cylindrical shape, typically, the length is 0.5 mm to 20 mm, the diameter is 0.2 mm to 20 mm, more typically, the length is 1 mm to 10 mm, and the diameter is 1 mm to 10 mm. It may be.

  Another aspect of the present invention is an orally administered drug for fish which is solid and adsorbed with fats and oils. “Oil and fat adsorbed” in this embodiment means that after forming a solid molded body by granulating a mixture of raw materials, the fat and oil were adsorbed on the solid molded body. In addition, an arbitrary process may be performed with respect to a solid molded object before and / or after making a solid molded object adsorb | suck fats and oils. Moreover, when manufacturing the solid fish orally administered medicine for fish which adsorb | sucked fats and oils, presence of fats and oils in the mixture of the raw material granulated is arbitrary. Therefore, after the solid molded body is formed, if it is not manufactured by adsorbing fats and oils to the molded body, even if the mixture of raw materials contains fats and oils, the obtained solid fish Orally administered drugs do not fall under the category of solid fish orally administered drugs that have oils and fats adsorbed on them. In the solid orally administered drug for fish in which the “fat is adsorbed”, the fats and oils to be adsorbed are not particularly limited, and examples thereof include palm oil, beef tallow, fish oil, and the like. Oil, beef tallow.

  In the embodiment of the solid orally administered drug for fish to which the fats and oils are adsorbed, the fats and oils adsorbed to the drug can be present at least on the surface and in the vicinity of the solid drug. When the orally administered drug for fish has a swollen structure, the adsorbed fat can penetrate into the solid structure. Further, by using special means such as reduced pressure, it is possible to adsorb fats and oils to the inside of the solid drug without an expanded structure. Oils and fats present on the surface of the solid drug, in the vicinity of the surface, and even in the inside thereof enclose the solid drug, that is, encapsulate it. As a result, solid orally administered drugs for fish that have oils and fats adsorbed thereon are relatively susceptible to physical impacts such as when frozen raw food is agitated with solid drugs when preparing feed for fish farming. Even if it is under, there exists an advantageous effect that disintegration of a solid medicine can be reduced and suppressed. Furthermore, the hydrophobic nature of the adsorbed oil itself has the effect of suppressing the release of medicinal components from the solid drug, so that when the solid drug is physically disrupted, There is an advantageous effect that it is possible to further suppress a decrease in the amount of food intake due to the release of the medicinal component from the drug, which can be significant when the amount of the medicinal component contained is increased.

  Another aspect of the present invention is a fish feed comprising the solid orally administered drug for fish. Although it does not specifically limit as a form of the feed for fish raising of this invention, Preferably, the feed for fish raising of this invention is a solid form, for example, a pellet form, More preferably, it is a moist pellet or an extruder pellet. Preferably, the solid orally administered drug for fish of the present invention is present in a state of being dispersed in a fish feed, for example, in a state of being dispersed in a pellet, and more preferably in a fish feed. In a uniformly dispersed state, for example, it exists in a substantially uniformly dispersed state in the pellet.

  The raw material for the feed for fish farming of the present invention may be a general raw material for the production of moist pellets for fish farming or extruder pellets, and is not particularly limited. Further, the production method can be produced by a general method except that the solid fish orally administered drug for fish of the present invention is used as one component of the raw material mixture. For example, a moist pellet feed for fish farming is The raw material mixture can be made by processing with a moist pellet machine, and the extruder pellet feed for fish farming is formed by extruding and granulating the raw material mixture with an extruder. It can be produced by drying. As will be shown in Examples and Comparative Examples described later, the solid orally administered drug for fish of the present invention has a higher hardness than those granulated without carbon powder. While not being bound by theory, this high hardness suppresses the collapse of the solid state of the drug when producing fish feed containing the drug, which is also due to the intake of medicinal ingredients. It is presumed that it contributes to the effects of the present invention, such as reduction or suppression of a decrease in the amount of food, and a sufficient medicinal effect.

  Moreover, about the ratio of the raw material of these feed, for example, when the feed for fish farming is a moist pellet, Preferably, it is 50-90 weight% of raw feed, 0-50 weight% of fish meal and a binder (or fish meal combination feed), Including, but not limited to, 0.5 to 2% by weight of vitamins and 1 to 20% by weight (total 100% by weight) of orally administered drugs for fish of the present invention. In addition, when the feed for fish farming is an extruder pellet, it is preferably 30 to 50% by weight of fish meal, 5 to 30% by weight of soybean meal, 1 to 5% by weight of starch, 3 to 20% by weight of fish oil, 1 to vitamin preparation 1 Including, but not limited to, 2% by weight, 1-20% by weight orally administered drug for fish of the present invention, and 10-20% by weight of water (total 100% by weight). The raw feed used as the raw material for the fish feed is not particularly limited as long as it is usually used for fish feed. For example, frozen sardines (sardines, anchovy), mackerels , Walleye pollack, saury, horse mackerel and the like. The fish meal is not particularly limited as long as it is usually used in fish feed, and examples thereof include anchovy, horse mackerel, and mackerel fish meal.

  The subject to which the feed for fish farming of the present invention is administered is not particularly limited as long as it is a fish, but preferably, perch fish, for example, yellowtail, red sea bream, sea mackerel, amberjack, sea bass, striped sea bream, chickfish, tuna, bluefin tuna, bribra , Flatfish, black sea bream, sea bream, sea bream, sea bream, pheasant sea bream, peppercorn, nizadai, cedar, giant crab, nibe, pheasant groupfish, cucumber, ara, isaki, chub mackerel, medaka, medina, tilapia, etc. Rainbow trout, trout, amago, char, salmon trout, salmon trout, salmon, etc., flounder fish, for example, flounder, starfish, flounder, matsukawa, puffer fish, for example, trough puffer, kingfish, horse sardine, etc. Yellowtail, amberjack, red sea bream, tuna, bluefin tuna, Salmon, rainbow trout, salmon, satsukimasu salmon, flounder, is rubripes the like, even more preferably, yellowtail, and amberjack.

One aspect of the present invention is a method for administering a drug to fish by allowing the fish to ingest a feed for fish farming that contains the solid drug for oral administration of fish of the present invention. Another aspect of the present invention is a method for preventing and / or treating fish diseases by allowing fish to feed a fish feed containing the solid orally administered drug for fish of the present invention. Diseases targeted for prevention and treatment are not particularly limited as long as they are fish-related during aquaculture. For example, bacterial diseases such as streptococci and nocardiosis, viral diseases, and beetles, aphids, schistosomes And parasitic diseases such as Moreover, the aspect which prevents and treats multiple types of disease simultaneously is also contained. The dose and administration period of the drug to the fish in the present invention vary depending on the kind of the medicinal component, the size of the target fish, the water temperature, etc., and are not particularly limited. For example, when praziquantel is used as a medicinal ingredient, it is preferably 5 mg / kg · day to 1000 mg / kg · day, more preferably 10 mg / kg · day to 500 mg / kg · day as praziquantel. The fish feed containing the solid pharmaceutical preparation for oral administration of fish of the present invention is administered to the fish so that the amount of the feed is increased. For example, the agent of the present invention can be administered daily at a dose of 5 mg / kg · day to 50 mg / kg · day of praziquantel for preventive administration for the purpose of preventing diseases. The therapeutic agent of the present invention can be administered for 3 days, for example, at a dose of 100 mg / kg · day to 150 mg / kg · day of praziquantel for therapeutic administration for the purpose of treating diseases. . Furthermore, when the drug of the present invention is intended to treat a disease by a single administration, for example, it is possible to administer a single dose of Pradiquantel at a dose of 450 mg / kg · day to 1000 mg / kg · day. Is possible. When the drug of the present invention is orally administered to fish, the medicinal components contained in the drug are absorbed into the fish body, and the medicinal effects can be exerted to prevent and / or treat fish diseases.
EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to the range of an Example.

Production Example 1: Solid fish orally administered medicine for fish according to the present invention formed by pressurizing and extruding granulation of a mixture containing Praziquantel and carbon powder with an extruder. manufactured. 20% by weight of Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.), 30% by weight of carbon powder (Goto Aquaculture Research Institute) and 50% by weight of wheat flour as a binder (Goto Aquaculture Research Institute, Ltd.) ) Under the conditions of a barrel temperature of 110 ° C. and a pressure of 1 to 2 Mpa with an extruder (Suehiro EPM Co., Ltd., 2-axis extruder EA-20; die diameter: 5 mm) and extrusion granulation to form a molded body. Thereafter, the molded body was dried with a hot air dryer to form a solid fish orally administered drug (length 5 mm, diameter 5 mm, praziquantel content 10 wt%). This drug did not have an expanded structure.

Production Example 2: Solid orally administered drug for fish of the present invention formed by extrusion granulation of a mixture containing Praziquantel and carbon powder with a pellet machine The orally administered drug for fish of the present invention was manufactured as follows. . 20% by weight Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.), 30% by weight carbon powder (Goto Culture Research Institute) and 50% by weight flour (Goto Culture Co., Ltd.) as excipients Formed by extrusion granulation with a disk pelleter (Dalton Co., Ltd.) using a mixture of the research laboratory), and is a solid orally administered drug for fish (length 5 mm, diameter 5 mm, praziquantel content 10% by weight) ) Was formed. This drug did not have an expanded structure.

Production Example 3: Solid orally administered drug for fish of the present invention having an expanded structure formed by pressing and extruding granulation of a mixture containing Praziquantel and carbon powder. Extruding and extruding with an extruder. Except that the barrel temperature at the tip was changed to 115 ° C. and the pressure was changed to 5.2 Mpa, the same method as in Production Example 1 was performed, and a solid fish orally administered drug for fish (length: 5 mm, diameter) 5.5 mm, content of plaziquantel 10% by weight).

Comparative Production Example 1: Solid orally administered drug for fish formed by pressing and extruding granulation of a mixture containing praziquantel but not carbon powder with an extruder. An orally administered drug for fish is produced as follows. It was. A mixture of 20% by weight Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) and 80% by weight flour (Goto Culture Research Institute) as a binder at a barrel temperature of 110 ° C. and a pressure of 1-2 Mpa. Pressed and extruded with an extruder (Suehiro EPM Co., Ltd., 2-axis extruder EA-20; die diameter 5 mm) under conditions to form a molded body, and then dried the molded body with a hot air dryer. Then, a solid orally administered drug for fish (length: 5 mm, diameter: 5 mm, praziquantel content: 10% by weight) was formed. This drug did not have an expanded structure.

Comparative Production Example 2: Orally administered drug for fish formed by extruding and granulating a mixture containing praziquantel but not carbon powder with a pellet machine An orally administered drug for fish was produced as follows. A mixture of 20% by weight Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) and 80% by weight flour (Goto Culture Research Institute) as an excipient was added to a pellet machine disk pelleter (stock) Extrusion granulation was carried out by a company Dalton Co., to form a molded product, and a solid fish drug for oral administration (length 5 mm, diameter 5.5 mm, praziquantel content 10% by weight) was formed. This drug did not have an expanded structure.

Comparative production example 3: Solid orally administered medicine for fish having a swollen structure formed by pressurizing and extruding granulation of a mixture containing plaziquantel but not containing carbon powder Pressurizing and extruding granulation with an extruder Except that the barrel temperature at the tip was changed to 115 ° C. and the pressure was changed to 5.2 Mpa, the same method as in Comparative Production Example 1 was carried out, and a solid fish orally administered drug for fish (length: 5 mm) , A diameter of 5.5 mm, and a content of plaziquantel of 10% by weight).

Examples 1-2
Production of Moist Pellet Feed for Fish Farming of the Present Invention Including Solid Fish Oral Administration Drug of the Present Invention Solid orally administered drug for fish (3% by weight) of the present invention produced in Production Example 1, frozen raw food (Sardine) (91 wt%), raw feed mash (Nippon Formula Feed Co., Ltd.) (6 wt%) raw materials are mixed using a moist pellet machine (Iwaki Electric IW-25, the same shall apply hereinafter) Moist pellet feed (diameter 9 mm) (Example 1) was prepared.
Similarly, a moist pellet feed for fish farming (diameter 9 mm) (Example 2) was prepared from the orally administered drug for fish produced in Production Example 2.

Comparative Examples 1-2
Production of Comparative Moist Pellet Feed for Fish Farming Comprising Comparative Solid Oral Drug for Fish Products Solid Fish Oral Administration Drug (3 wt%) produced in Comparative Production Example 1, frozen raw food (sardine) ) (91% by weight), raw feed mash (Nippon Formula Feed Co., Ltd.) (6% by weight) is mixed using a moist pellet machine, and a moist pellet feed for fish farming (diameter 9 mm) (Comparative Example 1) )created.
Similarly, a moist pellet feed for fish farming (diameter 9 mm) (Comparative Example 2) was prepared from the orally administered drug for fish produced in Comparative Production Example 2.

Comparative Example 3
Manufacture of moist pellet feed for fish farming of comparative examples using powdery medicinal ingredients as feed raw materials Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) (0.6% by weight), frozen raw feed (Sardine) (93.4% by weight), raw feed mash (Nippon Formula Feed Co., Ltd.) (6% by weight) are mixed using a moist pellet machine, and the moist pellet feed for fish farming (diameter 9 mm) It was created.

Comparative Example 4
Production of Moist Pellet Feed for Fish Farming as Comparative Example Using Powdered Medicinal Components and Carbon Powder as Feed Raw Materials Praziquantel 50% Powder ⁽ Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) (0.6% by weight) Raw material containing carbon powder (0.9% by weight), frozen raw food (sardine) (92.5% by weight), and commercial feed mash (Nippon Formulad Feed Co., Ltd.) (6% by weight) using a moist pellet machine By mixing, a moist pellet feed for fish farming (diameter 9 mm) was prepared.

Control group Manufacture of moist pellet feed for fish farming for the control group that does not contain medicinal ingredients Ingredients containing frozen raw food (sardine) (94% by weight), commercially available feed mash (Japan Compound Feed Co., Ltd.) (6% by weight), A moist pellet feed for fish farming (diameter 9 mm) was prepared by mixing using a moist pellet machine.

Test 1:
Each fish farm moist pellet feed produced as described above was orally administered to fish, and the feeding rate and the effect of controlling the stag beetle were examined. The test methods and results are as follows.

Method for Oral Administration of Drugs to Fish and Feeding Rate Measurement Method One hundred candies with a body weight of about 500 g, which was kept in a 4 m long × 4 m × 3 m deep ginger, was taken as one test group. Moist pellet feed for fish farming containing different orally administered drugs for each test group was administered. In each test area, after feeding for 2 days, the above-mentioned moist pellet feed for fish farming was administered to the amberjack in an amount that would be 3% by weight of fish body weight per day (15 g moist pellet feed / 500 g fish body weight). Ingested orally. This administration was performed for 3 consecutive days. Twenty-four hours after each administration on each day of the administration, 5 beetles were captured and dissected from the ginger, and the contents of each stomach were weighed. Calculated. For each administration day, the ratio of the average food intake of each drug administration group when the average food intake of the control group of the moist pellet feed was 100% was defined as the food intake rate (%). In addition, the efficacy evaluation in Table 1 shows that when the drug is able to sufficiently eliminate the stag beetle, the drug has a moderate stagnation effect, but the body has a medicinal component concentration in the body that is a parasitic part of the beetle. When the intravascular fluke (Paradetonacylix grandispinus, Paradetonacylix campampi) parasitizing in the blood vessel higher than the surface was sufficiently exterminated, it was represented as ◯; when the drug was not effective for oral administration of a medicinal component, it was represented as x.

Method for judging the effect of control of damselfly Before the administration of the moist pellet feed for fish farming containing orally administered drugs and 24 hours after the administration on the third day, five amberjacks were captured from each test area and parasitized after being immersed in fresh water for 3 minutes. The number of the common beetles was counted, and the average number of the beetles parasitizing per amberjack was calculated.

The feed administered to each test group is as follows.
As a control group, the moist pellet feed for fish farming which did not contain the medicinal component produced as described above was administered.
As Example 1, the moist pellet feed for fish farming of Example 1 of the present invention containing a solid fish orally administered drug containing praziquantel and carbon powder produced by an extruder pellet manufacturing method was administered.
As Comparative Example 1, the moist pellet feed for fish farming of Comparative Example 1 containing a solid fish orally administered drug containing praziquantel but not containing carbon powder produced by the extruder pellet manufacturing method was administered.
As Example 2, the moist pellet feed for fish farming of Example 2 of the present invention containing a solid orally administered drug for fish containing praziquantel and carbon powder produced by a dry pellet manufacturing method was administered.
As Comparative Example 2, the moist pellet feed for fish farming of Comparative Example 2 containing a solid orally administered drug for fish that contains praziquantel but does not contain carbon powder, produced by a dry pellet manufacturing method, was administered.
As comparative example 3, the moist pellet feed for fish farming of comparative example 3 containing powdered plaquater as a raw material was administered.
As Comparative Example 4, the moist pellet feed for fish farming of Comparative Example 4 containing powdered plastic quantel and carbon powder as raw materials was administered. The results are shown in Table 1 below.

  The low preference of Praziquantel in fish is evident from the results of Comparative Example 3 in which a fish moss pellet feed mixed with powdered Praziquantel was administered. That is, in Comparative Example 3, the feeding rate was 70% on the first day of administration, showing a slight decrease compared to the control group, but on the second and third days of administration, the feeding rate was 7% and 5%, respectively. The bait was suppressed. The result of 70% on the first day is considered that the hungry state of the fish by stopping feeding for the previous two days had overcome to some extent the suppression of feeding by Praziquantel. As can be seen in Comparative Example 4, even if carbon powder was simply mixed with the feed raw material together with the powdered plastic quantel, it was not possible to alleviate the suppression of feeding due to the plastic quantantel. As seen in Comparative Example 1 and Comparative Example 2, Praziquantel was prepared as an extruder pellet manufacturing method (Comparative Example 1) (described as EP manufacturing method in the table) or a dry pellet manufacturing method (Comparative Example 2) (described as DP manufacturing method in the table). No matter how it was solidified, no reduction in food intake was observed without carbon powder. In these Comparative Examples 1 to 4, no scab control effect was observed. It is presumed that the intake of Praziquantel into the fish body decreased due to a decrease in the feeding rate, and as a result, the concentration of Praziquantel in the body was not sufficient to exhibit the effect of controlling the damselfly.

  On the other hand, as observed in Example 1 and Example 2, when the solidified product of the mixture containing praziquantel and carbon powder was used as a drug, feeding suppression due to the preference of praziquantel was completely suppressed (implemented) Example 1) or mitigation (Example 2) was carried out, and along with this, the effect of extermination of the beetle was confirmed. Feeding rate of 31% and 33% on day 2 and day 3 in Example 2 where the mixture containing Praziquantel and carbon powder was solidified by dry pellet manufacturing method, and more than half of the beetle control after 3 days of administration The ratio is a level that can sufficiently contribute to the economics of aquaculture. In consideration of this feeding rate and the blood concentration of plaziquantel after the second day of Example 1 in Test 2 described later, it is estimated that the blood concentration of Praziquantel after the second day of Example 2 will be about 0.6 ppm. Is done. Here, as reported in Non-Patent Document 2, Praziquantel is effective against schistosomiasis of bluefin tuna at a concentration of 0.2 ppm in an in vitro test. The species of the bluefin tuna intravascular flukes and the beetle intravascular flukes are the same flukes, but the Praquantante is effective at the same concentration against the campipha vascular flukes (Paradetonacylix grandispinus and Paradetonacylix campampchi). It's thought to be. Therefore, in Example 2, it can be said that it is sufficiently effective against intravascular fluke. Moreover, in Example 1 which solidified by the extruder pellet manufacturing method, while being able to suppress the food intake fall by Praziquantel completely, about 95% of the parasitic beetle was able to be exterminated. In Example 1, considering the results of the blood concentration of Praziquantel in Test 2 described later, it was clear that it had sufficient efficacy against intravascular fluke. Therefore, the solid oral administration drug for fish according to the present invention can not only reduce or suppress the decrease in food intake by masking the low preference of praziquantel, but it can also be absorbed into the fish body after ingestion. It was clarified that the drug has a medicinal effect.

Test 2:
The blood concentration and the muscle concentration of Praziquantel (indicated as PZQ in the table) in the control group of Test 1 and the fish in the test groups of Example 1, Comparative Example 1 and Comparative Example 3 were measured. Specific test methods and results are as follows.

In each test group, 5 amberjacks were captured and blood and muscle were collected from each fish every 24 hours after administration of the feed. For blood, 2 ml of ethanol was added to about 0.5 g of blood, stirred and treated with ultrasonic waves for 1 minute, and this was filtered through a 0.45 μm membrane filter to obtain a sample solution for HPLC. For muscle, 10 ml of ethanol was added to about 1 g of muscle, treated with a homogenizer for 2 minutes, and filtrated through a 0.45 μm membrane filter as a sample solution for HPLC. As a standard solution for determining the concentration of Praziquantel, 100 mg of Praziquantel standard product was precisely weighed and dissolved in 20 ml of ethanol, and then diluted to 10 μg / ml with water at the time of use to obtain a standard solution. These sample solutions were analyzed using HPLC. The HPLC analysis conditions were as follows: measurement wavelength 210 nm, column ODS (Waters smoke C18), flow rate 1.0 ml / min, column temperature 40 ° C., mobile phase acetonitrile: water = 50: 50, injection volume 10 μl.
The results are shown in Table 2 below.

  Comparative Example 3 in which a fish moss pellet feed mixed with powdered prica quantel was administered, and a drug containing a solid mixture containing plaziquantel but not carbon powder by an extruder pellet manufacturing method (described as EP manufacturing method in the table) was used. In Comparative Example 1, the concentration of Praziquantel in blood and muscle was remarkably low after the second day. This result corresponds to the result of the Hadamushi control effect shown in Table 1. On the other hand, in Example 1 using the solid oral administration drug for fish of the present invention, increase in the concentration of praziquantel with continuation of oral administration was observed in both blood and muscle. . The results of the blood and muscle concentration of praziquantel in Example 1 correspond to the results of the Hadamushi control effect in Test 1.

Test 3:
In order to confirm the effects of the prior art, a fish moist pellet feed containing various medicinal ingredients is produced using the prior art, tested under the same conditions as in Test 1, and the feed rate of the feed is examined. went.
The control group, Comparative Example 3 and Comparative Example 4 are the same as in Test 1 above.
In Comparative Example 5, instead of Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) as a medicinal component, erythromycin 20% powder (Erythromycin powder "TG" 20% for fisheries, Toyo Technical Research Institute) A fish mist pellet feed produced as in Comparative Example 3 was administered except that (0.6 wt%) was used.
In Comparative Example 6, instead of Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) as an active ingredient, erythromycin 20% powder (Erythromycin powder for fishery "TG" 20%, Toyo Technical Research Institute) A fish mist pellet feed produced as in Comparative Example 4 was administered except that (0.6 wt%) was used.
In Comparative Example 7, erythromycin 20% powder (Erythromycin powder "TG" 20% for fisheries, Toyo Technical Research Institute) (0.6% by weight) and Praziquant 50% (Hadaclean ^{(registered trademark)} , Bayer The moist pellet feed for fish farming produced as in Comparative Example 3 was administered except that Yakuhin Co., Ltd. (0.6 wt%) was used.
In Comparative Example 8, erythromycin 20% powder (fishery erythromycin powder "TG" 20%, Toyo Technical Research Institute, Inc.) (0.6% by weight) and Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd. (0.6% by weight) was used, and the moist pellet feed for fish farming produced as in Comparative Example 4 was administered.
In Comparative Example 9, instead of Pradiquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin Co., Ltd.) as a medicinal ingredient, 10% ampicillin powder (10% ampicillin powder "TG" for fisheries, Toyo Technical Research Institute) Moist pellet feed for fish farming produced as in Comparative Example 3 was administered except that (4 wt%) was used.
In Comparative Example 10, ampicillin 10% powder (ampicillin powder “TG” for fisheries 10%, Toyo Technical Research Institute) (4% by weight) and Prajiquater 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin, Ltd. Co., Ltd. (0.6% by weight) was used, and the moist pellet feed for fish farming produced as in Comparative Example 3 was administered.
In Comparative Example 11, 10% of ampicillin powder (ampicillin powder "TG" for fisheries 10%, Toyo Engineering Laboratory Co., Ltd.) (4% by weight) and Praziquantel 50% powder (Hadaclean ^{(registered trademark)} , Bayer Yakuhin, Ltd. Co., Ltd. (0.6% by weight) was used, and the moist pellet feed for fish farming produced as in Comparative Example 4 was administered. The results are shown in Table 3 below.

  When the fish mist pellet feed contains powdered plaquantante or powdered erythromycin, the feed rate of these feeds is low, indicating that these drugs have low fish preference. On the other hand, the result of Comparative Example 9 shows that ampicillin does not affect the feeding rate. Further, from the results of Comparative Example 4, Comparative Example 6, Comparative Example 8, and Comparative Example 11 using the conventional technique intended for masking by simply mixing carbon powder, it is found that the addition of carbon powder or praziquantel or erythromycin It turns out that the fall of the feeding rate resulting from the low preference of can not be reduced or suppressed.

Test 4:
The physical properties of the solid drug for oral administration of fish of the present invention were examined.
With respect to the solid orally administered drugs for fish of Production Examples 1 and 3 and Comparative Production Examples 1 and 3, the disintegration hardness was measured using a tablet hardness meter A type 15 kg (Higaki Medical Science Co., Ltd.). The hardness average was calculated and the results are shown in Table 4. Regarding the solid orally administered medicines for fish of Production Example 3 and Comparative Production Example 3 having an expanded structure, the state of bubbles was observed using a stereomicroscope, and a sketch of the results is shown in FIG. As shown in 1) and FIG. 2 (Comparative Production Example 1), the size of bubbles was measured with an objective micrometer, and the average and standard deviation of 10 bubbles were calculated. The results are shown in Table 4. In addition, PZQ in a table | surface shows a plastic quantel, and EP manufacturing method shows that the chemical | medical agent was granulated by the extruder pellet manufacturing method.

  Regarding the diameter of the bubbles, compared with the bubbles (FIG. 2) formed in the solid drug of Comparative Production Example 3 that was granulated without using carbon powder, it was granulated using carbon powder. Further, the solid drug of the present invention of Production Example 3 had a small bubble diameter and a small variation (FIG. 1).

  Regarding the disintegration hardness, comparing the solid drugs granulated without using carbon powder as 100% each, the solid drug of the present invention is manufactured without an expanded structure manufactured by the extruder pellet manufacturing method. It showed an increase of 237% for the drug of Example 1 and as much as 350% for the drug of Production Example 3 having an expanded structure granulated by the extruder pellet method.

  The solid orally administered drug for fish of the present invention can be used for fish feed, and this fish feed can be used for fish farming.

Claims (12)

  An orally administered drug for solid fish, formed by a method comprising a step of granulating a mixture comprising a medicinal ingredient and carbon powder.   The solid orally administered medicine for fish according to claim 1, wherein the mixture containing a medicinal component and carbon powder further contains a binder.   The solid orally administered medicine for fish according to claim 1 or 2, wherein the step of granulating the mixture is a step of pressurizing and extruding the mixture.   The solid orally administered medicine for fish according to claim 3, wherein the step of pressurizing and extruding the mixture is performed in an extruder.   The solid orally administered medicine for fish according to any one of claims 1 to 4, wherein the solid orally administered medicine for fish has a swollen structure.   The solid orally administered drug for fish according to any one of claims 1 to 5, wherein fats and oils are adsorbed.   The solid orally administered drug for fish according to any one of claims 1 to 6, wherein the medicinal component contains praziquantel.   A feed for fish farming comprising the solid pharmaceutical preparation for oral administration of fish according to any one of claims 1 to 7.   The fish feed according to claim 8, wherein the fish feed is a moist pellet or an extruder pellet.   A method for administering a drug to fish by feeding the fish feed according to claim 8 or 9 to the fish.   A method for preventing and / or treating fish diseases by allowing fish to feed the feed for fish farming according to claim 8 or 9.   A method for producing a solid orally administered drug for fish, comprising a step of granulating a mixture containing a medicinal component and carbon powder.

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