CN101062066A - Compound isatis-root injection for animals and the preparing method thereof - Google Patents
Compound isatis-root injection for animals and the preparing method thereof Download PDFInfo
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- CN101062066A CN101062066A CNA2007101057420A CN200710105742A CN101062066A CN 101062066 A CN101062066 A CN 101062066A CN A2007101057420 A CNA2007101057420 A CN A2007101057420A CN 200710105742 A CN200710105742 A CN 200710105742A CN 101062066 A CN101062066 A CN 101062066A
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Abstract
The invention discloses a compound isatic root injection for animals and preparation technology, which is characterized by the following: allocating main medicine, adjunct and dissolvent; choosing the main medicine from isatic root, linbevelin, moroxydine and amantadine hydrochloride; choosing the adjunct from anti-oxidant, metal chelating agent and dissolvent for injection. This invention possesses advanced productive technology and long shelf life.
Description
Technical field
The present invention relates to a kind of compound isatis-root injection for animals and preparation technology thereof.
Background technology
With the Chinese medicine Radix Isatidis through extracting extractum and ribavirin, moroxydine hydrochloride, amantadine hydrochloride in a kind of be the compound isatis-root injection for animals that primary raw material is made, have heat-clearing and toxic substances removing, press down multiple virus functions such as resisiting influenza virus, parainfluenza virus, respiratory syncytial virus, Marek's.To the control animal viral disease, to improve body disease-resistant power effect remarkable.The hazardness of animal viral disease is very big, has a strong impact on growth of animal, makes animal products downgrade such as breast, meat, hair, leather, and quantity reduces, and prevent and treat untimelyly, easily causes large quantities of poultry death, causes tremendous economic loss to the raiser.Some zoonosis can also directly threaten human beings'health and life security.At present, veterinary clinic is used to prevent and treat the animal viral disease medicine seldom, and is generally single preparations of ephedrine, can not satisfy the veterinary clinic needs.For this reason, develop and a kind ofly can prevent and treat animal viral disease, can improve the new veterinary drug compound preparation of body disease-resistant power again, have meaning of crucial importance.
Summary of the invention
The purpose of this invention is to provide a kind of compound isatis-root injection for animals.
Another object of the present invention provides a kind of preparation technology of compound isatis-root injection for animals.
The present invention is achieved like this, it comprises principal agent, additives and solvent, wherein principal agent by weight portion Radix Isatidis 100～1000 through extracting extractum and the following raw materials in part by weight medicine in a kind of formulated: ribavirin 5～50, moroxydine hydrochloride 10～100, amantadine hydrochloride 5～50; Wherein additives are formulated by following substances in parts by weight: antioxidant 1～2, metal chelating agent 0.1～0.2, solubilizing agent 2～20; Wherein solvent is formulated by following substances in parts by weight: solvent for injection 700～970; Described antioxidant is that in sodium sulfite, sodium sulfite, the sodium thiosulfate one or more are used; Metal chelating agent is a disodiumedetate; Solubilizing agent is a polyoxyethylene sorbitan monoleate; Solvent for injection is that in ethanol, propylene glycol, glycerol, the water for injection one or more are used.
Preparation technology of the present invention is: take by weighing the recipe quantity Radix Isatidis through extracting extractum and a kind of medicine in the ribavirin, moroxydine hydrochloride, amantadine hydrochloride, add respectively in an amount of solvent for injection, and add solubilizing agent, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to full dose, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
The compound isatis-root injection for animals of the present invention's development includes a kind of pharmaceutical compositions in Chinese medicine Radix Isatidis and ribavirin, moroxydine hydrochloride, the amantadine hydrochloride.Wherein Radix Isatidis has heat-clearing and toxic substances removing, the antiviral function; Ribavirin, moroxydine hydrochloride, amantadine hydrochloride tool broad-spectrum disease resistance cytotoxic activity, the effect of multiple viruses such as suppressing influenza virus, parainfluenza virus, respiratory syncytial virus, Marek's is arranged, be mainly used to prevent and treat animal viral disease, improve body disease-resistant power.
Advantage of the present invention is: (1) develops a kind of Chinese and Western compound recipe veterinary drug novel formulation for veterinary clinic; (2) reasonable recipe, the Chinese medicine of employing and medicinal chemicals are antiviral efficient medicine; (3) production technology advanced person, preparation stabilization, storage period is long; (4) curative effect is better than including the single preparations of ephedrine of each medicine; (5) safe in utilization, determined curative effect, quality controllable; (6) dosage is accurate, and is easy to use.
The specific embodiment
Embodiment one
Radix Isatidis 500g ribavirin 25g
Preparation method of the present invention: take by weighing extractum, the ribavirin of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to 1000ml, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Embodiment two
Radix Isatidis 1000g ribavirin 50g
Preparation method of the present invention: get extractum, the ribavirin of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to 1000ml, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Embodiment three
Radix Isatidis 500g moroxydine hydrochloride 50g
Preparation method of the present invention: get extractum, the moroxydine hydrochloride of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to 1000ml, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Embodiment four
Radix Isatidis 1000g moroxydine hydrochloride 100g
Preparation method of the present invention: get extractum, the moroxydine hydrochloride of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to 1000ml, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Embodiment five
Radix Isatidis 500g amantadine hydrochloride 25g
Preparation method of the present invention: get extractum, the amantadine hydrochloride of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to full dose, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Embodiment six
Radix Isatidis 1000g amantadine hydrochloride 50g
Preparation method of the present invention: take by weighing extractum, the amantadine hydrochloride of recipe quantity Radix Isatidis, add respectively in an amount of solvent for injection, and add solubilizing agent through extracting, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to 1000ml, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Result of study
1. compound isatis-root injection for animals main pharmacodynamics research of the present invention
Compound isatis-root injection for animals of the present invention by the Chinese medicine Radix Isatidis through extracting extractum and a kind of medicine in the ribavirin, moroxydine hydrochloride, amantadine hydrochloride form.Wherein Radix Isatidis has heat-clearing and toxic substances removing, the antiviral function; Ribavirin, moroxydine hydrochloride, amantadine hydrochloride are antiviral agents, its mechanism of action is to enter by rapid phosphorylation behind the cell of viral infection, competitive inhibition virus synzyme, guanosine triphosphate (GTP) reduces in the cell thereby make, infringement viral RNA and protein synthesis are suppressed duplicating of virus.Compound isatis-root injection for animals of the present invention proves through clinical trial, and the curative effect of control animal viral disease, raising body disease-resistant power obviously is better than the single preparations of ephedrine of above-mentioned antiviral drugs.
2. the main pharmacokinetic studies of compound isatis-root injection for animals of the present invention
It is rapid that this product is injected the interior post-absorption of body, gets final product peaking at short period blood drug level, and medicine can enter in the erythrocyte, and amount of savings is big.Cerebrospinal fluid giving drugs into nose concentration can reach 67% of same time blood concentration behind the long-term prescription.Mainly through renal excretion.
3. the clinical application effect of compound isatis-root injection for animals of the present invention
Compound isatis-root injection for animals of the present invention carries out curative effect relatively by the single preparations of ephedrine with this product prescription medication.The experimental animal grouping:
(1) drug test group FUFANG BANLANGEN ZHUSHEYE
(2) medicine contrasts 1 group of Radix Isatidis injection
(3) medicine contrasts 2 groups of ribavirin injections
(4) medicine contrasts 3 groups of moroxydine hydrochloride injection
(5) medicine contrasts 4 groups of amantadine hydrochloride injection
(6) positive controls infects not administration group
(7) the blank group does not infect not administration group
Show by clinical trial, compound isatis-root injection for animals of the present invention compares with Radix Isatidis injection, ribavirin injection, moroxydine hydrochloride injection, amantadine hydrochloride injection matched group respectively, curative effect strengthens, be better than writing out a prescription each single preparations of ephedrine of medication is the ideal medicament of treatment viral disease on the veterinary clinic.
Claims (3)
1, a kind of compound isatis-root injection for animals, it is characterized in that it comprises principal agent, additives and solvent, wherein principal agent by weight portion Chinese medicine Radix Isatidis 100～1000 through extracting extractum and the following raw materials in part by weight medicine in a kind of formulated: ribavirin 5～50, moroxydine hydrochloride 10～100, amantadine hydrochloride 5～50; Wherein additives are formulated by following substances in parts by weight: antioxidant 1～2, metal chelating agent 0.1～0.2, solubilizing agent 2～20; Wherein solvent is formulated by following substances in parts by weight: solvent for injection 700～970.
2, be that in sodium sulfite, sodium sulfite, the sodium thiosulfate one or more are used according to claims 1 described antioxidant; Metal chelating agent is a disodiumedetate; Solubilizing agent is a polyoxyethylene sorbitan monoleate; Solvent for injection is that in ethanol, propylene glycol, glycerol, the water for injection one or more are used.
3, preparation technology of the present invention is: take by weighing the recipe quantity Radix Isatidis through extracting extractum and a kind of medicine in the ribavirin, moroxydine hydrochloride, amantadine hydrochloride, add respectively in an amount of solvent for injection, and add solubilizing agent, stirring and dissolving adds recipe quantity antioxidant, metal chelating agent, stirring and dissolving more respectively, add solvent for injection to full dose, regulate pH value, filter, cooling was sterilized 30 minutes in embedding for 100 ℃, lamp inspection, lettering, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101057420A CN101062066A (en) | 2007-05-29 | 2007-05-29 | Compound isatis-root injection for animals and the preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101057420A CN101062066A (en) | 2007-05-29 | 2007-05-29 | Compound isatis-root injection for animals and the preparing method thereof |
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| CN101062066A true CN101062066A (en) | 2007-10-31 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397510A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
| CN108578638A (en) * | 2018-06-19 | 2018-09-28 | 吉林百年汉克制药有限公司 | A kind of ribavirin injection pharmaceutical composition and its preparation method and application |
| CN109568257A (en) * | 2018-12-24 | 2019-04-05 | 江西润泽药业有限公司 | A kind of ribavirin injection and preparation method thereof |
| CN109602698A (en) * | 2018-12-24 | 2019-04-12 | 江西润泽药业有限公司 | A kind of benefit Ba Weilin composite injection and preparation method thereof |
-
2007
- 2007-05-29 CN CNA2007101057420A patent/CN101062066A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102397510A (en) * | 2011-11-15 | 2012-04-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken Marek's disease and preparation method thereof |
| CN108578638A (en) * | 2018-06-19 | 2018-09-28 | 吉林百年汉克制药有限公司 | A kind of ribavirin injection pharmaceutical composition and its preparation method and application |
| CN109568257A (en) * | 2018-12-24 | 2019-04-05 | 江西润泽药业有限公司 | A kind of ribavirin injection and preparation method thereof |
| CN109602698A (en) * | 2018-12-24 | 2019-04-12 | 江西润泽药业有限公司 | A kind of benefit Ba Weilin composite injection and preparation method thereof |
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Open date: 20071031 |