CN102973584B - Composition for treating nematodosis in dogs and cats, and preparation method thereof - Google Patents
Composition for treating nematodosis in dogs and cats, and preparation method thereof Download PDFInfo
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- CN102973584B CN102973584B CN201210512363.4A CN201210512363A CN102973584B CN 102973584 B CN102973584 B CN 102973584B CN 201210512363 A CN201210512363 A CN 201210512363A CN 102973584 B CN102973584 B CN 102973584B
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Abstract
The invention relates to a composition for treating nematodosis in dogs and cats. The composition is prepared by mixing the following ingredients in parts by weight: 5-10 parts of ivermectin, 10-20 parts of pyrantel pamoate, and 70-85 parts of starch. The composition has the beneficial effects of being reasonable in formula, simple to prepare, and obvious in curative effects, having special effects in treating nematodosis in dogs and cats, proved clinically.
Description
Technical field
The present invention relates to a kind of composition and method of making the same for the treatment of dog cat nematicide, belong to field of animal, particularly a kind of composition and method of making the same being specifically designed to treatment dog cat nematicide.
Background technology
Dog cat nematicide is the parasitic disease caused by the nematicide of main parasitic in dog cat intestinal, and ill poultry often show as retarded growth, inappetence, dysentery, becomes thin, anemia etc., finally can die because dying of exhaustion.This disease causes very large threat to the house pet aquacultures such as dog cat.
At present, treat main use of this disease and have the Chinese medicine and Western medicine that drive nematicide effect, Western medicine is owing to being that folk prescription easily produces drug resistance or compound recipe prescription is unreasonable, and therapeutic effect is not very desirable; And Chinese medicine powder particle diameter is comparatively large, bioavailability is low, and onset is slower.
Therefore the medicine researching and developing a kind of effective treatment dog cat nematicide is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe, preparation composition and method of making the same that is simple, effectively treatment dog cat nematicide are provided.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of dog cat nematicide, by following component by weight mixed preparing form: ivermectin 5-10 part, Pyrantel Pamoate 10-20 part, starch 70-85 part.
Described various component optimum ratio amount is: ivermectin 7.5 parts, Pyrantel Pamoate 15 parts, starch 77.5 parts.
Treat a preparation method for the compositions of dog cat nematicide, carry out as follows:
(1) take ivermectin 5-10 part by weight, starch 5-10 part, mix 5-10 minute to even;
(2) take Pyrantel Pamoate 10-20 part, starch 10-20 part by weight, mix 5-10 minute to even;
(3) merge the obtained mixture of above-mentioned (1), (2) step and remaining starch, continue mixing 10-15 minute to evenly, granulation, tabletting (making 1000) and get final product.
The medicinal property of each component is as follows:
Ivermectin: white crystalline powder, tasteless, be the semi-synthetic Macrolide multi-component antibiotic produced by Avid kyowamycin fermentation.The mechanism of action is the release of the inhibitory transmitter γ-aminobutyric acid increasing polypide, and open the chloride channel of glutamic acid control, strengthen neurolemma to the permeability of chloride ion, thus the transmission of block nerves signal, final neural paralysis, make muscle cell lose contractility, and cause polypide dead.Ivermectin is novel wide spectrum, efficient, low toxicity antibiotics antiparasitic, to endoparasite and ectoparasite particularly nematicide have and well kill effect.
Pyrantel Pamoate: pale yellow powder, odorless, tasteless, for wide spectrum, efficiently drive intestinal nematodes medicine.The mechanism of action is by suppressing acetylcholine esterase, making polypide muscle strong contraction, and cause spastic paralysis and excrete; In addition, it can make the depolarization of polypide individual cells, and spike potential provides frequency to be increased, and muscular tension also increases, and makes polypide lose autonomic activities.Can higher concentration be reached at gastrointestinal tract after this product is for oral administration, have good anthelminthic effect to dog cat more than 10 kind of intestinal nematodes.
Above two kinds of medicines are according to medicinal theory compatible combination, and both complement each other at the mechanism of action, have good potentiation.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Clinical practice proves, has specially good effect to treatment dog cat nematicide.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of composition and method of making the same for the treatment of dog cat nematicide: carry out as follows: (every part by 10g)
(1) take ivermectin 50 parts by weight, starch 50 parts, mix 5-10 minute to even;
(2) take Pyrantel Pamoate 100 parts, starch 100 parts by weight, mix 5-10 minute to even;
(3) merge the obtained mixture of above-mentioned (1), (2) step and remaining starch, continue mixing 10-15 minute to evenly, granulation, tabletting (making 10000) and get final product.
Embodiment 2
A kind of composition and method of making the same for the treatment of dog cat nematicide: carry out as follows: (every part by 10g)
(1) take ivermectin 75 parts by weight, starch 75 parts, mix 5-10 minute to even;
(2) take Pyrantel Pamoate 150 parts, starch 150 parts by weight, mix 5-10 minute to even;
(3) merge the obtained mixture of above-mentioned (1), (2) step and remaining starch, continue mixing 10-15 minute to evenly, granulation, tabletting (making 10000) and get final product.
Embodiment 3
A kind of composition and method of making the same for the treatment of dog cat nematicide: carry out as follows: (every part by 10g)
(1) take ivermectin 100 parts by weight, starch 100 parts, mix 5-10 minute to even;
(2) take Pyrantel Pamoate 200 parts, starch 200 parts by weight, mix 5-10 minute to even;
(3) merge the obtained mixture of above-mentioned (1), (2) step and remaining starch, continue mixing 10-15 minute to evenly, granulation, tabletting (making 10000) and get final product.
Clinical trial:
Clinical experiment animal selects 220-250 age in days, body weight at 10kg-15kg, and Laboratory Diagnosed is the ill dog of dog nematosis.Ill dog isolation raised separately, complete feedstuff of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experimental period carries out 7 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group by the ill dog of product of the present invention (compositions obtained by the embodiment of the present invention 1) feeding, day dose be: per kilogram of body weight 0.5, every day 1 time; Reached the object of disease therapy by gastrointestinal absorption after oral.After medication, 7 days excrement check ovum 1 time, identify and count.What calculate medicine drives clean rate and essence meter deworming rates, and carries out statistical analysis.Computational methods: drive clean rate=completely anthelmintic number of animals/experimental animal number × 100%, worm's ovum number × 100% before essence meter deworming rates=(before administration after worm's ovum number-administration worm's ovum number)/administration.Following table is the result (testing the 7th day) at the end of experiment.
Table 1 is that the situation that the present invention and other medicines treat chicken ascariasis contrasts:
| Numbering | Group | Drive clean rate % | Essence meter deworming rates % |
| I | Blank group | 10.2 | 29.8 |
| II | Ergamisole group | 78.9 | 81.1 |
| III | Present composition group | 88.7 | 89.5 |
This clinical effectiveness statistical analysis, present composition group and Ergamisole group counts in deworming rates two with essence and are compared difference all extremely remarkable (P < 0.01) driving clean rate.
Clinical experiment animal selects 150-200 age in days, body weight at 5kg-10kg, and Laboratory Diagnosed is the ill cat of cat nematicide.Ill cat isolation raised separately, complete feedstuff of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and drug control group " Ergamisole " by specification uses treatment; Present composition group by the ill cat of product of the present invention (compositions obtained by the embodiment of the present invention 1) feeding, day dose be: per kilogram of body weight 0.25, every day 1 time; Reached the object of disease therapy by gastrointestinal absorption after oral.After medication, 7 days excrement check ovum 1 time, identify and count.What calculate medicine drives clean rate and essence meter deworming rates, and carries out statistical analysis.Computational methods: drive clean rate=completely anthelmintic number of animals/experimental animal number × 100%, worm's ovum number × 100% before essence meter deworming rates=(before administration after worm's ovum number-administration worm's ovum number)/administration.Following table is the result (testing the 7th day) at the end of experiment.
Table 2 is that the situation that the present invention and other medicines treat cat nematicide contrasts:
| Numbering | Group | Drive clean rate % | Essence meter deworming rates % |
| I | Blank group | 10.7 | 35.6 |
| II | Ergamisole group | 82.6 | 86.2 |
| III | Present composition group | 91.5 | 95.9 |
This clinical effectiveness statistical analysis, present composition group and Ergamisole group counts in deworming rates two with essence and are compared difference all remarkable (P < 0.05) driving clean rate.
Safety testing:
Choose 150 age in days healthy dogs 30, feed 10 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1, during medication, healthy dogs is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Choose 100 age in days Healthy Cats 30, feed 10 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1, during medication, Healthy Cats is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of carrying out with reference to the composition and method of making the same of embodiment to this treatment dog cat nematicide; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (2)
1. treat a compositions for dog cat nematicide, it is characterized in that by following component by weight mixed preparing form: ivermectin 5-10 part, Pyrantel Pamoate 10-20 part, starch 70-85 part;
Preparation method is carried out as follows:
(1) take ivermectin 5-10 part by weight, starch 5-10 part, mix 5-10 minute to even;
(2) take Pyrantel Pamoate 10-20 part, starch 10-20 part by weight, mix 5-10 minute to even;
(3) merge the obtained mixture of above-mentioned (1), (2) step and remaining starch, continue mixing 10-15 minute to evenly, granulation, tabletting and get final product.
2. the compositions for the treatment of dog cat nematicide according to claim 1, it is characterized in that by following component by weight mixed preparing form: ivermectin 7.5 parts, Pyrantel Pamoate 15 parts, starch 77.5 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210512363.4A CN102973584B (en) | 2012-11-22 | 2012-11-22 | Composition for treating nematodosis in dogs and cats, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210512363.4A CN102973584B (en) | 2012-11-22 | 2012-11-22 | Composition for treating nematodosis in dogs and cats, and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102973584A CN102973584A (en) | 2013-03-20 |
| CN102973584B true CN102973584B (en) | 2014-12-31 |
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| CN201210512363.4A Expired - Fee Related CN102973584B (en) | 2012-11-22 | 2012-11-22 | Composition for treating nematodosis in dogs and cats, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108670974A (en) * | 2018-06-13 | 2018-10-19 | 四川农业大学 | A kind of broad-spectrum anti-parasite chewable tablets and preparation method thereof |
| CN115624531A (en) * | 2022-10-19 | 2023-01-20 | 陕西天宠生物科技有限公司 | Beef granule vermifuge for pets and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207179B1 (en) * | 2000-05-18 | 2001-03-27 | Phoenix Scientific, Inc. | Parasiticidal formulation for animals and a method of making this formulation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207179B1 (en) * | 2000-05-18 | 2001-03-27 | Phoenix Scientific, Inc. | Parasiticidal formulation for animals and a method of making this formulation |
Non-Patent Citations (1)
| Title |
|---|
| Thomas J. Nolan,等.Efficacy of an ivermectin/pyrantel pamoate chewable formulation against the canine hookworms, Uncinaria stenocephala and Ancylostoma caninum.《Veterinary Parasitology》.1992,第41卷121-125. * |
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