CN102784166B - The compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis - Google Patents
The compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis Download PDFInfo
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- CN102784166B CN102784166B CN201210269856.XA CN201210269856A CN102784166B CN 102784166 B CN102784166 B CN 102784166B CN 201210269856 A CN201210269856 A CN 201210269856A CN 102784166 B CN102784166 B CN 102784166B
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Abstract
The present invention relates to a kind of compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis, by following component by weight mixed preparing form: ivermectin 0.5-1.0 part, sulfur 15-25 part, propylene glycol 50-70 part, stearic acid 10-30 part, ethanol 10-30 part.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and toxic and side effects is little, and Chinese and Western combines, treating both the principal and secondary aspects of a disease, and bioavailability is high, curative effect highly significant, and clinical proof has specially good effect to treatment domestic animal acariasis.
Description
Technical field
The present invention relates to the compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis, belong to field of animal, particularly a kind of compound ivermectin composition and method of making the same being specifically designed to treatment domestic animal acariasis.
Background technology
Domestic animal acariasis is a kind of high degree in contact, the infectious dermatosis that are caused in animal body surface or epidermis by mites infest, loses hair or feathers for feature with itch all over and affected part.This disease of animal infection, often occurs that symptom, the bodies such as play is itched, depilation are become thin gradually, affect growth promoter, more do not caused death for a long time.Primary disease sickness rate and case fatality rate are all very high, all can occur throughout the year, are one of principal diseases of harm livestock culturing industry.
This disease is all livestock culturing countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And Western medicine application method is mainly based on oral, be difficult to arrive the problems such as skin because oral way has strong, the easy drug resistance and drug residue and medicine of producing of toxic and side effects, clinical effectiveness is not fine.
Therefore researching and developing a kind of specific medicament for the treatment of domestic animal acariasis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, there is provided a kind of reasonable recipe, preparation is simple, and Chinese and Western combines, treating both the principal and secondary aspects of a disease, toxic and side effects is little, and bioavailability is high, the compound ivermectin composition and method of making the same of effective treatment domestic animal acariasis of curative effect highly significant.
Implementation of the present invention is as follows for achieving the above object: a kind of compound ivermectin compositions for the treatment of domestic animal acariasis, by following component by weight mixed preparing form: ivermectin 0.5-1.0 part, sulfur 15-25 part, propylene glycol 50-70 part, stearic acid 10-30 part, ethanol 10-30 part.
On the basis of such scheme, described various component optimum ratio amount is: ivermectin 0.75 part, 20 parts, sulfur, propylene glycol 60 parts, stearic acid 20 parts, ethanol 20 parts.
Treat a preparation method for the compound ivermectin compositions of domestic animal acariasis, it is characterized in that carrying out as follows:
(1) 700 mesh sieves are crossed by after the sulfur micronizing in prescription;
(2) take propylene glycol 50-70 part by weight, add ivermectin 0.5-1.0 part, be heated to 80 DEG C and make it dissolve, be stirred to evenly;
(3) take ethanol 10-30 part by weight and add sulfur 15-25 part, be stirred to evenly;
(4) (3) are added in (2), and add stearic acid 10-30 part, heated and stirred to being uniformly dissolved, cold filtration and get final product.
The medicinal property of each component is as follows:
Sulfur: sour, warm, poisonous, returns kidney, large intestine channel, has and mends function that is fiery supporing yang, relieving constipation; Cure mainly yang deficiency constipation, deficiency and coldness asthma, scabies, carbuncle of yin nature malignant boil etc.
Ivermectin: white crystalline powder, is novel wide spectrum, efficient, low toxicity antibiotics antiparasitic, all has well kill effect to endoparasite and ectoparasite.
All herbal medicines are according to the theoretical compatible combination of pharmacology above, for paathogenic factor and the clinical symptoms of domestic animal acariasis, play the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine Western medicine combines, treating both the principal and secondary aspects of a disease, and cost is low, and draw materials wide, micronizing, bioavailability are high, curative effect highly significant.Clinical practice proves, has specially good effect to treatment domestic animal acariasis.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the sulfur micronizing in prescription;
(2) take propylene glycol 500 parts by weight, add ivermectin 5 parts, be heated to 80 DEG C and make it dissolve, be stirred to evenly;
(3) take ethanol 100 parts by weight and add 150 parts, sulfur, be stirred to evenly;
(4) (3) are added in (2), and add stearic acid 100 parts, heated and stirred to being uniformly dissolved, cold filtration and get final product.
Embodiment 2
A kind of compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the sulfur micronizing in prescription;
(2) take propylene glycol 600 parts by weight, add ivermectin 7.5 parts, be heated to 80 DEG C and make it dissolve, be stirred to evenly;
(3) take ethanol 200 parts by weight and add 200 parts, sulfur, be stirred to evenly;
(4) (3) are added in (2), and add stearic acid 200 parts, heated and stirred to being uniformly dissolved, cold filtration and get final product.
Embodiment 3
A kind of compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the sulfur micronizing in prescription;
(2) take propylene glycol 700 parts by weight, add ivermectin 10 parts, be heated to 80 DEG C and make it dissolve, be stirred to evenly;
(3) take ethanol 300 parts by weight and add 250 parts, sulfur, be stirred to evenly;
(4) (3) are added in (2), and add stearic acid 300 parts, heated and stirred to being uniformly dissolved, cold filtration and get final product.
Clinical trial:
Clinical experiment animal selects 100-150 age in days, body weight at 20kg-30kg, and Laboratory Diagnosed is the ill sheep of sheep acariasis.Ill sheep isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, experimental period 7 days; Blank group is left intact, and drug control group " wiping scabies to fall apart " by specification uses treatment; Product of the present invention (compositions obtained by the embodiment of the present invention 1) directly can be applied to affected part by Chinese medicine composition group of the present invention, once a day, is used in conjunction 5-7 days.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 7th day) at the end of experiment.
Table is that the situation that the present invention and other medicines treat sheep acariasis contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 10.0 | 63.3 | 26.7 |
| II | Wipe scabies to fall apart group | 6.7 | 80.0 | 13.3 |
| III | Present composition group | 3.3 | 90.0 | 6.7 |
This clinical effectiveness statistical analysis, present composition treatment group and wipe scabies fall apart group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 150 age in days Healthy Sheep 10, affected part is embrocated 5 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1, during medication, Healthy Sheep is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of carrying out with reference to the compound ivermectin composition and method of making the same of embodiment to this treatment domestic animal acariasis; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (1)
1. treat a compound ivermectin compositions for domestic animal acariasis, it is characterized in that by following component by weight mixed preparing form: ivermectin 0.75 part, 20 parts, sulfur, propylene glycol 60 parts, stearic acid 20 parts, ethanol 20 parts;
Concrete preparation method is as follows:
(1) 700 mesh sieves are crossed by after the sulfur micronizing in prescription;
(2) take propylene glycol 60 parts by weight, add ivermectin 0.75 part, be heated to 80 DEG C and make it dissolve, be stirred to evenly;
(3) take ethanol 20 parts by weight and add 20 parts, sulfur, be stirred to evenly;
(4) (3) are added in (2), and add stearic acid 20 parts, heated and stirred to being uniformly dissolved, cold filtration and get final product.
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| CN201210269856.XA CN102784166B (en) | 2012-08-01 | 2012-08-01 | The compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis |
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| CN201210269856.XA CN102784166B (en) | 2012-08-01 | 2012-08-01 | The compound ivermectin composition and method of making the same for the treatment of domestic animal acariasis |
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| CN102784166B true CN102784166B (en) | 2015-11-25 |
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| WO2004026033A1 (en) * | 2002-09-20 | 2004-04-01 | Artpharm Pty Ltd | Plant pesticides and uses thereof |
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| FR2854074B1 (en) * | 2003-04-24 | 2007-11-23 | Galderma Res & Dev | USE OF IVERMECTIN FOR THE TREATMENT OF DERMATOLOGICAL DISORDERS |
| CN102440944A (en) * | 2010-10-08 | 2012-05-09 | 内蒙古农业大学 | Ivermectin transdermal liniment for animals |
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