CN102499973B - Compound propolis composition for treating dog and cat scabies and preparation method thereof - Google Patents
Compound propolis composition for treating dog and cat scabies and preparation method thereof Download PDFInfo
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- CN102499973B CN102499973B CN201110443101.2A CN201110443101A CN102499973B CN 102499973 B CN102499973 B CN 102499973B CN 201110443101 A CN201110443101 A CN 201110443101A CN 102499973 B CN102499973 B CN 102499973B
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Abstract
The invention relates to a compound propolis composition for treating dog and cat scabies and a preparation method thereof, belonging to the field of animal medicine. The preparation method of the compound propolis composition comprises the following steps: (1) weighting 5-10 parts by weight of propolis ethanol extract, 5-10 parts by weight of golden larch bark ethanol extract, 5-10 parts by weight ofradix stemonae ethanol extract, 5-10 parts by weight of sophora flavescens ethanol extract, 5-10 parts by weight of felwort ethanol extract, 45 parts by weight of 75% ethanol and 20-45 parts by weight of distilled water; (2) putting the propolis ethanol extract, the golden larch bark ethanol extract and the radix stemonae ethanol extract into 25 parts of 75% ethanol, and stirring uniformly for 5-10 minutes; (3) taking 15 parts of 75% ethanol, adding the sophora flavescens ethanol extract and the felwort ethanol extract in sequence, and stirring for dissolving; and (4) mixing the solution prepared in the steps (2) and (3), stirring uniformly, standing for 15-20 minutes, and adding the left 5 parts of 75% ethanol and the 20-45 parts of distilled water after the liquid medicine is clear, stirring uniformly and filtering. The compound propolis composition has reasonable components, is easy to prepare and use and has significant curative effect.
Description
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment dog cat acaricide and preparation method thereof.
Background technology
Dog cat acaricide is to parasitize by sarcoptes canis or the cat back of the body anus demodicid mite dermatosis causing in dog cat skin skin, infection site is spread to whole body by part, and erythema, pimple, incrustation, depilation appear in pars affecta skin, as secondary infection can be brought out septicemia, that ill dog cat becomes thin gradually, until dead.The dog cat of various ages and kind all can occur, and case fatality rate is all between 1%-10%.Primary disease all can occur throughout the year, is one of principal disease of the house pets such as serious harm dog cat.
This disease almost spreads all over the house pets such as all dog cats in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine, antimicrobial drug and anthelmintic, Chinese medicine is because its prescription is unreasonable or be simple powder, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug and anthelmintic be because life-time service easily produces drug resistance, its clinical effectiveness worse and worse, thereby the use of antimicrobial drug is very restricted.
Therefore researching and developing a kind of specific medicament producing that has no drug resistance for the treatment of dog cat acaricide is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation is simple, bioavailability is high, the compound bee-glue composition of successful and effective treatment dog cat acaricide of having no drug resistance and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of dog cat acaricide, by following component by weight mixed preparing form: propolis ethanol extract 5-10 part, Cortex Pseudolaricis ethanol extract 5-10 part, Radix Stemonae ethanol extract 5-10 part, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water.
On the basis of such scheme, described various component optimum ratio amounts are: 8 parts of propolis ethanol extract, 7 parts of Cortex Pseudolaricis ethanol extract, 8 parts of Radix Stemonae ethanol extract, 8 parts of Radix Sophorae Flavescentis ethanol extract, 7 parts of Radix Gentianae ethanol extract, 45 parts of 75% ethanol, 35 parts of distilled water.
Treat a preparation method for the compound bee-glue composition of dog cat acaricide, carry out as follows:
(1) take by weight 5～10 parts of propolis ethanol extract, 5～10 parts of Cortex Pseudolaricis ethanol extract, 5～10 parts of Radix Stemonae ethanol extract, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water;
(2) described propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 75% ethanol of 25 parts, stirred 5～10 minutes to even;
(3) get 15 parts of 75% ethanol, add successively Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of described umber, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, keep 15～20 minutes, add 5 parts of described residue 75% ethanol, 20～45 parts of distilled water after medicinal liquid is clear and bright, filtration stirs.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, have anti-inflammation, pain relieving only overworked, promote tissue regeneration, improve immunity, the function of antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Cortex Pseudolaricis: pungent, warm, return lung, spleen channel, there is parasite killing, stop overworked function; Cure mainly scabies pruritus etc.
The Radix Stemonae: sweet, bitter, return lung meridian, there is the function of nourishing the lung to arrest cough, parasite killing; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery, scabies etc.
Radix Gentianae: bitter, cold, return liver, gallbladder meridian, there is eliminating pathogen in the liver gallbladder excess-fire, except the function of damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema scabies overworked etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of dog cat acaricide, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no drug resistance, and cost is low, draws materials wide, and using method simply, is directly smeared disease sites, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Chinese medicine of the five flavours, and makes them according to optimum ratio, form pure Chinese medicinal liquor, and clinical practice proves that treatment dog cat acaricide is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) take by weight 50 parts of propolis ethanol extract, 50 parts of Cortex Pseudolaricis ethanol extract, 50 parts of Radix Stemonae ethanol extract, 50 parts of Radix Sophorae Flavescentis ethanol extract, 50 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 350 parts of distilled water;
(2) described propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 75% ethanol of 250 parts, stirred 5～10 minutes to even;
(3) get 150 parts of 75% ethanol, add successively Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of described umber, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, keep 15～20 minutes, add 50 parts of described residue 75% ethanol, 350 parts of distilled water after medicinal liquid is clear and bright, filtration stirs.
Embodiment 2
A kind of compound bee-glue composition for the treatment of dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) take by weight 80 parts of propolis ethanol extract, 70 parts of Cortex Pseudolaricis ethanol extract, 80 parts of Radix Stemonae ethanol extract, 70 parts of Radix Sophorae Flavescentis ethanol extract, 80 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 350 parts of distilled water;
(2) described propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 75% ethanol of 250 parts, stirred 5～10 minutes to even;
(3) get 150 parts of 75% ethanol, add successively Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of described umber, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, keep 15～20 minutes, add 50 parts of described residue 75% ethanol, 350 parts of distilled water after medicinal liquid is clear and bright, filtration stirs.
Embodiment 3
A kind of compound bee-glue composition for the treatment of dog cat acaricide and preparation method thereof: carry out as follows: (every part by 10g)
(1) take by weight 100 parts of propolis ethanol extract, 100 parts of Cortex Pseudolaricis ethanol extract, 100 parts of Radix Stemonae ethanol extract, 100 parts of Radix Sophorae Flavescentis ethanol extract, 100 parts of Radix Gentianae ethanol extract, 450 parts of 75% ethanol, 450 parts of distilled water;
(2) described propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 75% ethanol of 250 parts, stirred 5～10 minutes to even;
(3) get 150 parts of 75% ethanol, add successively Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of described umber, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, keep 15～20 minutes, add 50 parts of described residue 75% ethanol, 450 parts of distilled water after medicinal liquid is clear and bright, filtration stirs.
Clinical trial:
Product of the present invention is directly smeared to the skin of ill dog cat, wet skin, every day 2-3 time, is used in conjunction 5-7 day.
Table is the field applicable cases contrast of the present invention and other medicines treatment dog cat acaricide:
| Numbering | Group | Case fatality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 5.5 | 77.0 | 17.5 |
| II | Acaricide spirit group | 4.3 | 84.9 | 10.8 |
| III | Present composition group | 1.5 | 92.8 | 5.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with acaricide spirit group aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment dog cat acaricide and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compound bee-glue composition for dog cat acaricide, it is characterized in that by following component by weight mixed preparing form: propolis ethanol extract 5-10 part, Cortex Pseudolaricis ethanol extract 5-10 part, Radix Stemonae ethanol extract 5-10 part, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water.
2. the compound bee-glue composition for the treatment of according to claim 1 dog cat acaricide, it is characterized in that by following component by weight mixed preparing form: 8 parts of propolis ethanol extract, 7 parts of Cortex Pseudolaricis ethanol extract, 8 parts of Radix Stemonae ethanol extract, 8 parts of Radix Sophorae Flavescentis ethanol extract, 7 parts of Radix Gentianae ethanol extract, 45 parts of 75% ethanol, 35 parts of distilled water.
3. a preparation method for the compound bee-glue composition for the treatment of according to claim 1 dog cat acaricide, is characterized in that carrying out as follows:
(1) take by weight 5～10 parts of propolis ethanol extract, 5～10 parts of Cortex Pseudolaricis ethanol extract, 5～10 parts of Radix Stemonae ethanol extract, Radix Sophorae Flavescentis ethanol extract 5-10 part, Radix Gentianae ethanol extract 5-10 part, 45 parts of 75% ethanol, 20～45 parts of distilled water;
(2) described propolis ethanol extract, Cortex Pseudolaricis ethanol extract, Radix Stemonae ethanol extract are put into 75% ethanol of 25 parts, stirred 5～10 minutes to even;
(3) get 15 parts of 75% ethanol, add successively Radix Sophorae Flavescentis ethanol extract, the Radix Gentianae ethanol extract of described umber, stirring and dissolving;
(4) merge the solution that above-mentioned (2) and (3) step make, stir, keep 15～20 minutes, add 5 parts of described residue 75% ethanol, 20～45 parts of distilled water after medicinal liquid is clear and bright, filtration stirs.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110443101.2A CN102499973B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat scabies and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110443101.2A CN102499973B (en) | 2011-12-27 | 2011-12-27 | Compound propolis composition for treating dog and cat scabies and preparation method thereof |
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| CN102499973A CN102499973A (en) | 2012-06-20 |
| CN102499973B true CN102499973B (en) | 2014-04-09 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103239594B (en) * | 2013-05-31 | 2015-03-25 | 勾陈松 | Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof |
| CN103385927A (en) * | 2013-07-16 | 2013-11-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for the treatment of animal acariasis |
| WO2017010858A1 (en) * | 2015-07-15 | 2017-01-19 | Flores Samaniego Beatriz | Composition based on extracts of heliopsis longipes and propolis for the control and/or elimination of ticks |
| CN107582943B (en) * | 2017-11-08 | 2020-09-11 | 山西农业大学 | Compound traditional Chinese medicine transdermal spray for preventing and treating animal sarcoptidosis and preparation method thereof |
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2011
- 2011-12-27 CN CN201110443101.2A patent/CN102499973B/en not_active Expired - Fee Related
Non-Patent Citations (5)
| Title |
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| 张丁华等.猫皮肤真菌病的诊治及预防.《兽医导刊》.2008,(第05期),45-46. |
| 李树荣，彭和禄，顾四润，余海龙，张培荣，孙定留.生物灭虫剂杀灭家畜体外寄生虫效果观察.《云南畜牧兽医》.1996,(第01期),29. * |
| 汪晶晶.藿黄洗剂的制备与临床应用.《时珍国医国药》.2001,第12卷(第05期),415. |
| 猫皮肤真菌病的诊治及预防;张丁华等;《兽医导刊》;20080515(第05期);45-46 * |
| 藿黄洗剂的制备与临床应用;汪晶晶;《时珍国医国药》;20010530;第12卷(第05期);415 * |
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