CN103520328A - Compound traditional Chinese medicine acne gel and preparation method thereof - Google Patents
Compound traditional Chinese medicine acne gel and preparation method thereof Download PDFInfo
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Abstract
The invention relates to compound traditional Chinese medicine acne gel and a preparation method of the compound traditional Chinese medicine acne gel. The compound traditional Chinese medicine acne gel comprises 5-20 parts of salviae miltiorrhizae, 10-30 parts of radix scutellariae, 10-35 parts of hedyotis diffusa, 15-35 parts of wild chrysanthemum, 5-20 parts of flos carthami, 10-25 parts of cynanchum atratum, 5-15 parts of liquorice, 5-20 parts of carbomer, 10-40 parts of triethanolamine, 15-40 parts of glycerol, 0.5-2 parts of ethylparaben, 30-70 parts of propylene glycol and 50-300 parts of distilled water. According to the compound traditional Chinese medicine acne gel, the gel is extracted from multiple kinds of Chinese traditional medicine, and chemical substances, such as a hormone and a pigment, harmful to the skin are not contained. Results of animal stimulation tests show that the compound traditional Chinese medicine acne gel is gentle to the skin and free of stimulation to the skin and side effects. The compound traditional Chinese medicine acne gel has the advantages of being easy to spread, fresh, cool, free of an oily feel, good in adhesiveness and homogeneity, easy to carry and the like. The compound traditional Chinese medicine acne gel remarkably improves the medicine utilization ratio. The combination of medicine of the prescription of the compound traditional Chinese medicine acne gel enables inflammation diminishment and recovery of the injured skin to be conducted simultaneously and the effects that acne is fully cured and acne post-inflammatory hyperpigmentation is eliminated as soon as possible are achieved.
Description
Technical field
The present invention relates to the medicine of Acne treatment and oily skin, acne skin health promoting product, particularly a kind of herbal mixture acne gel and preparation method thereof.
Background technology
It is vigorous that modern study shows that the pathogenesis of acne is generally considered to be smegma, follicular epithelium hypertrophy, and sebaceous gland opening is blocked and cause, and relevant with the infection of corynebacterium acnes, anaerobe and part Grain-positive bacillus.Acne external curing dosage form has ointment, cream, lotion, liniment etc. now, and such dosage form has certain deficiency for the treatment of acne, and as ointment, cream itself contain oiliness composition, the acne treatment vigorous for smegma has a certain impact; And the medicine adhesive force such as lotion, liniment are not enough, be easily subject to the impact of sweat.In addition, adopt the treatment of Western medicine acne ointment can produce the problems such as drug resistance and dependency.How to choose is a kind of both simple and efficient, be easy to carry about with one and side effect little, possess heat-clearing and toxic substances removing removing heat from blood simultaneously, and remove as early as possible the generally acknowledged thorny difficult problem that Pigmented Therapeutic Method after scytitis and inflammation just becomes acne treatment aspect.
Summary of the invention
Problem in view of above-mentioned existing medicine exists, the object of the present invention is to provide a kind of herbal mixture acne gel and preparation method thereof.This medicine be take Chinese crude drug as primary raw material, take aqueous gel as substrate, is prepared into use simply, and acne gel evident in efficacy, for the health promoting product of acne treatment and acne species skin, oily skin.
The technical solution adopted in the present invention is: a kind of herbal mixture acne gel, it is characterized in that, and described gel pack contains the component of following parts by weight: Radix Salviae Miltiorrhizae 5-20 part, Radix Scutellariae 10-30 part, Herba Hedyotidis Diffusae 10-35 part, Herba Dendranthematis indici 15-35 part, Flos Carthami 5-20 part, Radix Cynanchi Atrati 10-25 part, Radix Glycyrrhizae 5-15 part, carbomer 5-20 part, triethanolamine 10-40 part, glycerol 15-40 part, ethyl hydroxybenzoate 0.5-2 part, propylene glycol 30-70 part, distilled water 50-300 part.
The parts by weight scope of preferred each component of the present invention is: Radix Salviae Miltiorrhizae 10-20 part, Radix Scutellariae 15-25 part, Herba Hedyotidis Diffusae 15-25 part, Herba Dendranthematis indici 15-25 part, Flos Carthami 5-15 part, Radix Cynanchi Atrati 10-20 part, Radix Glycyrrhizae 5-15 part, carbomer 10-20 part, triethanolamine 10-20 part, glycerol 20-30 part, propylene glycol 50-60 part, ethyl hydroxybenzoate 0.5-1 part, distilled water 50-150 part.
The parts by weight of each component of the best of the present invention are: 15 parts of Radix Salviae Miltiorrhizaes, 20 parts of Radix Scutellariaes, 20 parts of Herba Hedyotidis Diffusaes, 20 parts, Herba Dendranthematis indici, 10 parts, Flos Carthami, 15 parts of Radix Cynanchi Atratis, 10 parts, Radix Glycyrrhizae, 12 parts of carbomers, 15 parts of triethanolamine, 25 parts of glycerol, 50 parts of propylene glycol, 1 part of ethyl hydroxybenzoate, 100 parts of distilled water.
A kind of preparation method of herbal mixture acne gel, it is characterized in that: first by Radix Salviae Miltiorrhizae, Radix Scutellariae, Herba Hedyotidis Diffusae, Herba Dendranthematis indici, Flos Carthami, Radix Cynanchi Atrati, Radix Glycyrrhizae mixes, add ethanol water to carry out reflux, extract, then merge extractive liquid, add active carbon to stir, sucking filtration to extracting solution is clarified, to extracting solution concentrating under reduced pressure, again carbomer is sprinkled in the medicinal liquid after concentrated under stirring, make after its complete swelling, under stirring, add glycerol, propylene glycol and with the ethyl hydroxybenzoate of dissolve with ethanol, finally slowly add triethanolamine to regulate pH value to 6, add distilled water, strengthen stirring dynamics, make gel mix homogeneously, fill after sterilizing.
The invention has the advantages that: adopt plurality of Chinese to extract, not containing chemical substances harmful to skin such as hormone, pigments.Through animal irritant test, show skin gentleness, non-stimulated, and have no side effect.Both overcome traditional emulsifiable paste, ointment etc. and easily blocked the shortcoming of sebaceous gland, also overcome the problem of the large or administration absorbance difference of the zest of tincture, lotion, liniment.This gel water solublity is strong, take low concentration carbomer as substrate, can obviously regulate sebum secretion.There is easy painting exhibition, clearly without greasy feeling, tack and having good uniformity, the advantage such as be easy to carry about with one, significantly improves utilization ratio of drug.Prescription compatibility of medicines makes antiinflammatory and repairs damaged skin and carry out simultaneously, reaches comprehensive Acne treatment, eliminates as early as possible Pigmented effect after acne inflammation.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described: in the preparation process of herbal mixture acne gel, according to Radix Salviae Miltiorrhizae, Radix Scutellariae, Herba Hedyotidis Diffusae, Herba Dendranthematis indici, Flos Carthami, Radix Cynanchi Atrati, the mixed weight of Radix Glycyrrhizae, adding volume is that the ethanol water that 8-12 doubly measures and concentration is 40%-70% carries out reflux, extract,, continuous circumfluence extraction 3 times, each 1-2h.According to the volume of extracting solution, the weight ratio that adds active carbon is 0.5%-2%.Add active carbon to stir 5-20 min, static 0.5-2h.Extracting solution is evaporated to the 1/2-1/4 of extracting liquid volume.The dissolve with ethanol that ethyl hydroxybenzoate is less than 10% by volume ratio.
Embodiment 1: 10 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Scutellariaes, 15 parts of Herba Hedyotidis Diffusaes, 25 parts, Herba Dendranthematis indici, 15 parts, Flos Carthami, 20 parts of Radix Cynanchi Atratis, 15 parts, Radix Glycyrrhizae, 10 parts of carbomer940 NF, 10 parts of triethanolamine, 20 parts of glycerol, 50 parts of propylene glycol, 0.5 part of ethyl hydroxybenzoate, 150 parts of distilled water.
By 1.0 kilograms of Radix Salviae Miltiorrhizaes, 1.5 kilograms of Radix Scutellariaes, 1.5 kilograms of Herba Hedyotidis Diffusaes, 2.5 kilograms, Herba Dendranthematis indici, 1.5 kilograms, Flos Carthami, 2.0 kilograms of Radix Cynanchi Atratis, 1.5 kilograms of mixing of Radix Glycyrrhizae, mixed weight is 11.5 kilograms, the ethanol water that to add 115 liters and concentration be 40% carries out reflux, extract,, extract 3 times continuously each 1h, then merge extractive liquid; The volume of merge extractive liquid, is 280 liters, adds the active carbon of 1.4 kilograms, stirs 5min, static 0.5h, and sucking filtration to extracting solution is clarified, and extracting solution is evaporated to 90 liters; Get in 1.0 kilograms of concentrated medicaments that are sprinkled under stirring of carbomer 934PNF, make after its complete swelling, under stirring, add 2.0 kilograms of glycerol, 5.0 kilograms of propylene glycol and with 0.1 kilogram of the ethyl hydroxybenzoate of 0.5 liter of dissolve with ethanol, finally slowly add 1.0 kilograms of triethanolamine, regulating pH value is 6, adds 15.0 kilograms of distilled water, then strengthens stirring dynamics, make gel mix homogeneously, fill after sterilizing.
Embodiment 2: 15 parts of Radix Salviae Miltiorrhizaes, 20 parts of Radix Scutellariaes, 20 parts of Herba Hedyotidis Diffusaes, 20 parts, Herba Dendranthematis indici, 10 parts, Flos Carthami, 15 parts of Radix Cynanchi Atratis, 10 parts, Radix Glycyrrhizae, 12 parts of Carbopol NF, 15 parts of triethanolamine, 25 parts of glycerol, 50 parts of propylene glycol, 1 part of ethyl hydroxybenzoate, 100 parts of distilled water.
By 1.5 kilograms of Radix Salviae Miltiorrhizaes, 2.0 kilograms of Radix Scutellariaes, 2.0 kilograms of Herba Hedyotidis Diffusaes, 2.0 kilograms, Herba Dendranthematis indici, 1.0 kilograms, Flos Carthami, 1.5 kilograms of Radix Cynanchi Atratis, 1.0 kilograms of mixing of Radix Glycyrrhizae, mixed weight is 11 kilograms, the ethanol water that to add 110 liters and concentration be 60% carries out reflux, extract,, extract 3 times continuously each 1.5h, then merge extractive liquid; The volume of merge extractive liquid, is 250 liters, adds the active carbon of 2.5 kilograms, stirs 10min, static 1h, and sucking filtration to extracting solution is clarified, and extracting solution is evaporated to 80 liters; Get in 1.2 kilograms of concentrated medicaments that are sprinkled under stirring of carbomer 980NF, make after its complete swelling, under stirring, add 2.5 kilograms of glycerol, 5.0 kilograms of propylene glycol and with 0.1 kilogram of the ethyl hydroxybenzoate of 0.5 liter of dissolve with ethanol, finally slowly add 1.5 kilograms of triethanolamine, regulating pH value is 6, adds 10 kilograms of distilled water, then strengthens stirring dynamics, make gel mix homogeneously, fill after sterilizing.
Embodiment 3: 20 parts of Radix Salviae Miltiorrhizaes, 25 parts of Radix Scutellariaes, 25 parts of Herba Hedyotidis Diffusaes, 25 parts, Herba Dendranthematis indici, 5 parts, Flos Carthami, 10 parts of Radix Cynanchi Atratis, 5 parts, Radix Glycyrrhizae, 20 parts of CARBOPOL 974P NF, 20 parts of triethanolamine, 30 parts of glycerol, 60 parts of propylene glycol, 1 part of ethyl hydroxybenzoate, 90 parts of distilled water.
By 2.0 kilograms of Radix Salviae Miltiorrhizaes, 2.5 kilograms of Radix Scutellariaes, 2.5 kilograms of Herba Hedyotidis Diffusaes, 2.5 kilograms, Herba Dendranthematis indici, 0.5 kilogram, Flos Carthami, 1.0 kilograms of Radix Cynanchi Atratis, 0.5 kilogram of mixing of Radix Glycyrrhizae, mixed weight is 115 kilograms, the ethanol water that to add 115 liters and concentration be 70% carries out reflux, extract,, extract 3 times continuously each 2h, then merge extractive liquid; The volume of merge extractive liquid, is 250 liters, adds the active carbon of 5 kilograms, stirs 20min, static 2h, and sucking filtration to extracting solution is clarified, and extracting solution is evaporated to 80 liters; Get in 2.0 kilograms of concentrated medicaments that are sprinkled under stirring of carbomer 974PNF, make after its complete swelling, under stirring, add 3.0 kilograms of glycerol, 6.0 kilograms of propylene glycol and with 0.1 kilogram of the ethyl hydroxybenzoate of 0.5 liter of dissolve with ethanol, finally slowly add 2.0 kilograms of triethanolamine, regulating pH value is 6, adds 9 kilograms of distilled water, then strengthens stirring dynamics, make gel mix homogeneously, fill after sterilizing.
The prepared Chinese medicine acne gel of above three embodiment is buff translucent gels state, has the special aroma of Chinese medicine.Comparatively speaking, in embodiment 1, gel mobility is better, but because viscosity is too low, tack is not strong; In embodiment 3, gel viscosity is higher, but stretchability is bad; In embodiment 2, gel viscosity is moderate, has good tack and stretchability.
The present invention is based on external treatment with Chinese medicine therapy, main effect is clearing away heat and cooling blood, eliminating stasis to stop pain.In gel, Radix Salviae Miltiorrhizae has the effect that promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, relieving restlessness are calmed the nerves.In Radix Salviae Miltiorrhizae, main chemical substance is TANSHINONES.TANSHINONES is both to gram-positive cocci, and particularly resistant Staphylococcus aureus has stronger antibacterial action, also has the effect of androgen antagonist sample.There is research also to confirm that TANSHINONES has the metabolic effect of accelerating skin.Radix Scutellariae has heat clearing and damp drying, the effect of removing pathogenic heat from blood and toxic substance from the body.Its vitro antibacterial activity is good.In modern medicine study proof Radix Scutellariae, Flavonoid substances has powerful antiinflammatory action, can effectively reduce capillary permeability, and the higher inhibitory action of dosage is more obvious.Baicalin contained in Radix Scutellariae can have the effect of androgen antagonist sample by suppressing androgen receptor expression in people's sebaceous cell.The main heat-clearing and toxic substances removing of Herba Hedyotidis Diffusae, dampness removing is treating stranguria.The demonstration of in-vitro antibacterial experimental result, total flavones of oldenlandia diffusa willd all has antibacterial and bactericidal action in various degree to common coccus and bacillus, has in addition certain antiinflammatory and anti-androgenic effect, participates in immunomodulating, suppresses smegma.Flos Chrysanthemi Indici heat-clearing toxin-expelling functions is distinguished.Modern pharmacological research confirmation, Flos Chrysanthemi Indici has stronger antiinflammatory sterilization and improves the function of immunity, and external can auxiliary treatment acne.Radix Cynanchi Atrati has clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, and the effect of detoxification sore treatment, can effectively treat the sore and toxic that heat in blood poison is contained, and Orally taken and externally all can.Flos Carthami promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Modern medicine finds that it has antiopxidant effect, improves microcirculation and antiinflammatory and suppresses the effect that capillary permeability increases.Radix Glycyrrhizae both can invigorating the spleen and replenishing QI, and coordinating the actions of various ingredients in a prescription again can expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain.Glycyrrhizic acid is the effective ingredient extracting from Radix Glycyrrhizae, and the zinc glycyrrhizate being synthesized by glycyrrhizic acid has the effect of the aspects such as similar hormone antiinflammatory, anti-immunity, but there is no the side effect of hormonelike, therefore be particularly suitable as hormone replacement thing Acne treatment.Seven flavor medicine gathers clearing away heat and cooling blood altogether, eliminating stasis to stop pain, the curative effect of the eliminating carbuncle of invigorating blood circulation.In medical material, main component and pharmacological action are in Table 1.
Table 1
Carbomer, as herbal mixture acne gel substrate, has stretchability good, without features such as greasy feelings, and the treatment of very applicable acne and other diseases; Propylene glycol, as penetration enhancer, guarantees effectively absorbing fast of gel Chinese medicine; In preparation, add glycerol as wetting agent, prevent xerosis cutis, keep the pliable and tough moisture state of skin, be conducive to the absorption of medicine; Ethyl hydroxybenzoate plays antibacterial antiseptical effect, and finally in gel, adding appropriate triethanolamine to pH value is 6, to approach the pH value of skin surface, improves the compliance of Drug therapy.Add again distilled water, to regulate the concentration of gel.
As the host material of gel, except selecting the carbomer of acrylate copolymer, can also select hypromellose, sodium carboxymethyl cellulose and chitosan etc. as the host material of gel.
As pH adjusting agent, except selecting triethanolamine, can also select ethylenediamine, sodium hydroxide, lauryl amine, sodium bicarbonate etc. as pH adjusting agent.
As wetting agent, except selecting glycerol, can also select hyaluronic acid, sodium lactate, trehalose, propylene glycol etc. as wetting agent.
As penetrating agent, except selecting propylene glycol, can also select the surfactants such as azone, aminoacid.
As antiseptic, except selecting ethyl hydroxybenzoate, can also select one or more in benzyl alcohol, chlorobutanol, thimerosal, hibitane, benzalkonium chloride, benzalkonium bromide, methyl hydroxybenzoate and propylparaben.
Herbal mixture acne gel zoopery process is summarized as follows:
Object: observe the preliminary curative effect of herbal mixture acne gel Acne treatment, inquire into the mechanism of Chinese medicine acne gel Acne treatment.
Method: adopt Kligman method, be coated with coal tar diluent (the 2% concentration liquor carbonis detergens that 95% ethanol is made into) every day in the adult New Zealand large ear rabbit auris dextra inboard ear tube opening 2cmx2cm of place scope, 0.25ml once, connects and is coated with 14 days, sets up acne experimental animal model.Set up herbal mixture acne gel high dose group (10%), herbal mixture acne gel low dose group (5%), tretinoin group.Every group of external used medicine is after 14 days, and perusal and pathological section observed under electron microscope, carry out classification according to grade scale, and the situation between each group is compared and statistical analysis, the effect of herbal mixture acne gel to rabbit Acne Model.
Result: each organized external used medicine after 14 days, 3 groups of rabbit ear situations are all improved in varying degrees.
Herbal mixture acne gel low dose group, perusal: rabbit ear epidermis thickens to some extent and alleviates, horn and smegma thing obviously reduce during compared with modeling, but still have, do not cure acne and exist.Microscopic observation: spine cell's number of plies returns to 4 layers by original 7-10 layer, and follicular orifice degrees of expansion alleviates, its interior angle compound is loose, and inflammatory cell reduces to some extent.
Herbal mixture acne gel high dose group, perusal: rabbit ear epidermal thickness to be to reach normal level, horn and smegma thing obviously reduce during compared with modeling.Microscopic observation: spine cell's number of plies has returned to the normal not layer 2-3 of the modeling rabbit ear, and inflammatory cell obviously reduces, and follicular orifice degrees of expansion alleviates, and part has returned to normal level.
Tretinoin group, perusal: desquamation is obvious, epidermal thickness has returned to normal level, not coarse being in the way of touching.Electron microscopic observation: spine cell's number of plies has returned to 4 layers of level, still has a small amount of loose keratinization material to fill.Intradermal inflammatory cell reduces.
Medication was carried out classification, statistical analysis according to grade scale after two weeks, compared: 3 group difference not statistically significants between group.
Conclusion: tretinoin group and 5%, 10% concentration herbal mixture acne gel group all can obtain certain curative effect to rabbit ear Acne Model.
Claims (10)
1. a herbal mixture acne gel, is characterized in that, described gel pack contains the component of following parts by weight: Radix Salviae Miltiorrhizae 5-20 part, Radix Scutellariae 10-30 part, Herba Hedyotidis Diffusae 10-35 part, Herba Dendranthematis indici 15-35 part, Flos Carthami 5-20 part, Radix Cynanchi Atrati 10-25 part, Radix Glycyrrhizae 5-15 part, carbomer 5-20 part, triethanolamine 10-40 part, glycerol 15-40 part, propylene glycol 30-70 part, ethyl hydroxybenzoate 0.5-2 part, distilled water 50-300 part.
2. a kind of herbal mixture acne gel according to claim 1, is characterized in that, wherein the parts by weight of each component are: Radix Salviae Miltiorrhizae 10-20 part, Radix Scutellariae 15-25 part, Herba Hedyotidis Diffusae 15-25 part, Herba Dendranthematis indici 15-25 part, Flos Carthami 5-15 part, Radix Cynanchi Atrati 10-20 part, Radix Glycyrrhizae 5-15 part, carbomer 10-20 part, triethanolamine 10-20 part, glycerol 20-30 part, propylene glycol 50-60 part, ethyl hydroxybenzoate 0.5-1 part, distilled water 50-150 part.
3. a kind of herbal mixture acne gel according to claim 1, is characterized in that, wherein the parts by weight of each component are: 15 parts of Radix Salviae Miltiorrhizaes, 20 parts of Radix Scutellariaes, 20 parts of Herba Hedyotidis Diffusaes, 20 parts, Herba Dendranthematis indici, 10 parts, Flos Carthami, 15 parts of Radix Cynanchi Atratis, 10 parts, Radix Glycyrrhizae, 12 parts of carbomers, 15 parts of triethanolamine, 25 parts of glycerol, 50 parts of propylene glycol, 1 part of ethyl hydroxybenzoate, 100 parts of distilled water.
4. according to the preparation method of claim 1, claim 2 or herbal mixture acne gel claimed in claim 3, it is characterized in that: it is that CARBOPOL 974P NF, Carbopol NF and carbomer940 NF are wherein a kind of that described component carbomer is selected model.
5. one kind as claim 1, the preparation method of claim 2 or herbal mixture acne gel claimed in claim 3, it is characterized in that: first by Radix Salviae Miltiorrhizae, Radix Scutellariae, Herba Hedyotidis Diffusae, Herba Dendranthematis indici, Flos Carthami, Radix Cynanchi Atrati, Radix Glycyrrhizae mixes, add ethanol water to carry out reflux, extract, then merge extractive liquid, add active carbon to stir, sucking filtration to extracting solution is clarified, to extracting solution concentrating under reduced pressure, again carbomer is sprinkled in the medicinal liquid after concentrated under stirring, make after its complete swelling, under stirring, add glycerol, propylene glycol and with the ethyl hydroxybenzoate of dissolve with ethanol, finally slowly add triethanolamine to regulate pH value to 6, add distilled water, strengthen stirring dynamics, make gel mix homogeneously, fill after sterilizing.
6. the preparation method of a kind of herbal mixture acne gel according to claim 5, it is characterized in that: according to Radix Salviae Miltiorrhizae, Radix Scutellariae, Herba Hedyotidis Diffusae, Herba Dendranthematis indici, Flos Carthami, Radix Cynanchi Atrati, the mixed weight of Radix Glycyrrhizae, adding volume is that the ethanol water that 8-12 doubly measures and concentration is 40%-70% carries out reflux, extract,, continuous circumfluence extraction 3 times, each 1-2h.
7. the preparation method of a kind of herbal mixture acne gel according to claim 6, is characterized in that: according to the volume of extracting solution, the weight ratio that adds active carbon is 0.5%-2%.
8. the preparation method of a kind of herbal mixture acne gel according to claim 7, is characterized in that: add active carbon to stir 5-20 min, static 0.5-2h.
9. the preparation method of a kind of herbal mixture acne gel according to claim 8, is characterized in that: the 1/2-1/4 that extracting solution is evaporated to extracting liquid volume.
10. the preparation method of a kind of herbal mixture acne gel according to claim 9, is characterized in that: the dissolve with ethanol that ethyl hydroxybenzoate is less than 10% by volume ratio.
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| CN105748573A (en) * | 2016-03-10 | 2016-07-13 | 广西大学 | Radix Glycyrrhizae cream and preparation method thereof |
| CN107405272A (en) * | 2015-04-13 | 2017-11-28 | 瑞帝安有限公司 | Sinapic acid comprising the index components as Radix Cynanchi Atrati extract or the skin regeneration with its Radix Cynanchi Atrati extract apply some make up composition and Wound healing and bone regeneration pharmaceutical compositions |
| CN107929150A (en) * | 2017-12-23 | 2018-04-20 | 芜湖皖江知识产权运营中心有限公司 | A kind of pox-eliminating whitening gel |
| CN107929210A (en) * | 2017-12-23 | 2018-04-20 | 芜湖皖江知识产权运营中心有限公司 | A kind of anti-acne moisturizing gel and preparation method thereof |
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| CN105748573A (en) * | 2016-03-10 | 2016-07-13 | 广西大学 | Radix Glycyrrhizae cream and preparation method thereof |
| CN105687049A (en) * | 2016-03-17 | 2016-06-22 | 韩存海 | Bath salt capable of effectively removing face pimples and preparation method |
| CN107929150A (en) * | 2017-12-23 | 2018-04-20 | 芜湖皖江知识产权运营中心有限公司 | A kind of pox-eliminating whitening gel |
| CN107929210A (en) * | 2017-12-23 | 2018-04-20 | 芜湖皖江知识产权运营中心有限公司 | A kind of anti-acne moisturizing gel and preparation method thereof |
| CN107961189A (en) * | 2017-12-23 | 2018-04-27 | 芜湖皖江知识产权运营中心有限公司 | A kind of preparation method of pox-eliminating whitening gel |
| CN107961188A (en) * | 2017-12-23 | 2018-04-27 | 芜湖皖江知识产权运营中心有限公司 | A kind of blemish clearing gel and preparation method thereof |
| CN110251624A (en) * | 2019-07-12 | 2019-09-20 | 杭州师范大学 | A kind of preparation method for the Cuo gel that disappears |
| CN112057543A (en) * | 2020-09-16 | 2020-12-11 | 西北大学 | A topical Chinese medicinal composition for treating acne, and its preparation method |
| CN112057543B (en) * | 2020-09-16 | 2022-03-18 | 西北大学 | A topical Chinese medicinal composition for treating acne, and its preparation method |
| CN112891446A (en) * | 2021-03-18 | 2021-06-04 | 蒋卫东 | Preparation process of traditional Chinese medicine formula of external weight-losing gel |
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| CN103520328B (en) | 2014-12-24 |
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Effective date of registration: 20190408 Address after: Room 4255, Building No. 49, 141 Lane, Fenggun Road, Haiwan Tourist Area, Fengxian District, Shanghai, 201418 Patentee after: Shanghai first non Pharmaceutical Technology Co., Ltd. Address before: 300193 Anshan West Road, Nankai District, Nankai District, Tianjin Patentee before: Tianjian TCM University |