CN105748573A - Radix Glycyrrhizae cream and preparation method thereof - Google Patents
Radix Glycyrrhizae cream and preparation method thereof Download PDFInfo
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- CN105748573A CN105748573A CN201610135527.4A CN201610135527A CN105748573A CN 105748573 A CN105748573 A CN 105748573A CN 201610135527 A CN201610135527 A CN 201610135527A CN 105748573 A CN105748573 A CN 105748573A
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- radix glycyrrhizae
- emulsifiable paste
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- licorice extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses Radix Glycyrrhizae cream, made from the following materials according to parts by weight: 20-30 parts of Radix Glycyrrhizae extract, 15-20 parts of a mineral oil, 25-30 parts of polydimethylsiloxane, 18-22 parts of meadowfoam seed oil, 40-42 parts of caprylic/capric triglyceride, 35-40 parts of agar stearic acid, 35-40 parts of glyceryl stearate and PEG-100 stearate, 30-40 parts of glycerol, 2-5 parts of sodium lauryl sulfate, 1-3 parts of methylparaben and propylparaben (3:1), and 900-1000 parts of distilled water; the cream developed from Radix Glycyrrhizae extract as a raw material is effective in diminishing inflammation, delaying skin senescence, improving skin pigmentation and the like, is useful in treating skin diseases such as contact dermatitis hand and foot skin chapping and chilblain, and slight inflammatory acnes and pigmentation of the face and neck and back.
Description
Technical field
The present invention relates to external preparation for skin pharmaceutical technical field, be specifically related to a kind of Radix Glycyrrhizae emulsifiable paste and preparation method thereof.
Background technology
Radix Glycyrrhizae, another name: state's grass old, sweet, Glycyrrhiza Uralensis, sweet root.Pulse family, Glycyrrhiza perennial herb, root and root shape
Stem is sturdy, is a kind of help Chinese herbal medicine.Record according to " legendary god of farming hundred grass warp ", Radix Glycyrrhizae have hard muscles and bones, long muscle, times strength and
The merit of removing toxic substances, can treating disorders in five ZANG-organs abdomen be cold, heat evil gas and the swollen effect of metal-inflicted wound；" Mingyi Bielu " is called " lantern, honey is sweet, state is old ",
And titled with the title of " kings of many medicines "." book on Chinese herbal medicine is just " write " property that Radix Glycyrrhizae must neutralize, has the merit adjusting benefit, therefore poison obtains it
Solving its poison, firm medicine obtains its property of sum, and what medicine administered to bring out the cold obtained helps outside it, its speed slow put in poison.Enter gas with gas medicine, enter blood with blood medicine,
Without toward can not, therefore claim state old ".Radix Glycyrrhizae through the checking of China traditional medicine long-term clinical practice, confirm its invigorate the spleen and benefit qi, heat-clearing
Removing toxic substances, timid phlegm and relieving cough, relieving spasm to stop pain, effect of coordinating the drug actions of a prescription, can be used for treating weakness of the spleen and the stomach, lassitude hypodynamia, palpitation,
Cough ant phlegm, abdominal cavity and the disease such as limbs pain, too fat to move sore, and with the toxicity of other medicine of alleviation.Research now shows, sweet
The type of compounds having been found that in grass and determine has triterpene saponin, glycyrrhiza total flavonoid class, alkaloid, polysaccharide, amino acid etc.,
Its extract mainly have antibacterial, anti-inflammatory, anti-oxidant, antiviral, anticancer, protect the liver, neuroprotective, hypoglycemic, whitening and enhancing
The effects such as memory, imply that Radix Glycyrrhizae hepatopathy, diabetes, ischemical reperfusion injury, Parkinson's disease, alzheimer's disease,
The aspects such as the treatment of the diseases such as epilepsy, depression, cancer and cosmetic applications have good development prospect.
Summary of the invention
It is an object of the invention to, for prior art, it is provided that a kind of Radix Glycyrrhizae emulsifiable paste and preparation method thereof.
For achieving the above object, the present invention takes techniques below scheme: the following components that a kind of Radix Glycyrrhizae emulsifiable paste contains mass parts:
Licorice extract 20～30 parts, Dormant oils 15～20 parts, dimethyl silicone polymer 25～30 parts, white pond flower seed oil 18～22 parts, pungent
Acid/Triglyceride DDD 40～42 parts, agar stearic acid 35～40 parts, stearine and PEG-100 stearate 35～40
Part, glycerine 30～40 parts, laruyl alcohol sodium sulfovinate 2～5 parts, methyl hydroxybenzoate and propylben (3:1) mixing preservative
1～3 part and distilled water 900～1000 parts.
Wherein, the preparation method of Radix Glycyrrhizae emulsifiable paste comprises the steps of aqueous phase and the oil phase weighing mass parts, respectively at 95 DEG C
Adding thermal agitation extremely in homogeneously, insulation is at about 75～80 DEG C, in the aqueous phase stirred adds oil phase, in the same direction, and limit
Edged stirs with rotating speed for 20r/min, after 30min, is cooled to 50 DEG C, adds licorice extract, and adjustment rotating speed is 2800r/min,
Homogeneous 3min, is cooled to 35～45 DEG C.
Further, the preparation method of described licorice extract is: Radix Glycyrrhizae is put clean draining, is placed in drying box,
Drying at 50～60 DEG C to constant weight, pulverize, cross 40 mesh sieves, use ultrasonic extraction, extracting liquorice powder 20g, solvent is 65%
Ethanol 180ml, is 100W at power, and frequency is 20kHz, under the conditions of temperature is 35～40 DEG C, carries out ultrasonic extraction
10～30min, licorice is refluxed three times, filters, be condensed into 1/10th of original volume.
Further, the extraction process of described Radix Glycyrrhizae uses ultrasonic assisted Extraction Technology, utilizes ultrasonic wave to produce strong shaking
Dynamic, produce high speed, strong cavitation effect, stirring action, destroy plant cell, make solvent can penetrate in plant cell,
Accelerate the dissolving of active ingredient in Radix Glycyrrhizae, shorten extraction time, improve the extraction efficiency of active component.
Further, in the present invention, oil phase is Dormant oils, dimethyl silicone polymer, white pond flower seed oil, caprylic/capric glycerine three
Fat, fine jade wax stearyl alcohol, stearine and PEG-100 stearate.
Further, in the present invention, aqueous phase is glycerine, laruyl alcohol sodium sulfovinate, licorice extract, methyl hydroxybenzoate and Buddhist nun
The mixing preservative of pool gold propyl ester (3:1) and distilled water.
Further, in the present invention, preservative selects methyl hydroxybenzoate and the mixing preservative of propylben (3:1), Buddhist nun
Pool tortoise beetle ester and propylben are used in mixed way, and have good additivity and concertedness, can suppress the growth of bacterium, extend breast
The shelf-life of cream.
Further, in the present invention, Radix Glycyrrhizae has, anti-inflammatory, antibacterial, anti-oxidant, antiviral, anticancer, protect the liver, neural
The effects such as protection, hypoglycemic, whitening and enhancing memory, wherein, licorice mainly contains triterpene soap bases and Flavonoid substances,
Triterpene substance mainly has glycyrrhizic acid, and Flavonoid substances is mainly containing liquiritin, and Flavonoid substances and triterpene compound are to active oxygen
Having scavenging action, thus have antioxidation, the process produced in tumour because of active oxygen and oxygen radical plays a significant role,
Therefore it also has antitumor action；Glycyrrhizin in Radix Glycyrrhizae has inhibitory action to the release of hyaluronic acid activity and histaminase, thus
Can be as the inhibitor of allergy, inflammation and thrombus.The liquiritin contained in Radix Glycyrrhizae has anti-inflammatory and disease-resistant allergy effect.
The invention has the beneficial effects as follows: in the licorice of the present invention, principle active component is glycyrrhizic acid and liquiritin, tool
The effects such as anti-inflammatory, anti-oxidant, regulation of skin melanin generation, the emulsion tool that the present invention makes with licorice for raw material research and development
Have anti-inflammatory, delay skin aging, improve the effect such as cutaneous pigmentation, can treat contact dermatitis hand-foot skin chap and pernio,
The disease of skin such as the slight inflammatory acne of neck surface and back and pigmentation.
Detailed description of the invention
Below in conjunction with specific embodiment, to further instruction of the present invention.
Embodiment 1
A kind of Radix Glycyrrhizae emulsifiable paste contains the following components of mass parts: licorice extract 20 parts, Dormant oils 15 parts, polydimethylsiloxanes
25 parts of alkane, white pond flower seed oil 18 parts, caprylic/capric triglyceride 40 parts, agar stearic acid 35 parts, stearine and
PEG-100 stearate 35 parts, glycerine 30 parts, laruyl alcohol sodium sulfovinate 2 parts, methyl hydroxybenzoate and propylben (3:
1) mixing preservative 1 part and distilled water 900 parts；
The preparation method of licorice extract is: Radix Glycyrrhizae is put clean draining, is placed in drying box, dries to constant weight at 50 DEG C,
Pulverizing, cross 40 mesh sieves, use ultrasonic extraction, extracting liquorice powder 20g, solvent is 65% ethanol 180ml, at power is
100W, frequency is 20kHz, under the conditions of temperature is 35 DEG C, carries out ultrasonic extraction 10min, is refluxed three times by licorice,
Filter, be condensed into 1/10th of original volume.
The preparation method of Radix Glycyrrhizae emulsifiable paste comprises the steps of aqueous phase and the oil phase weighing mass parts, heats respectively and stir at 95 DEG C
Mixing in homogeneously, insulation is at about 75 DEG C, and in the aqueous phase stirred adds oil phase, in the same direction, limit edged is with rotating speed
Stirring for 20r/min, after 30min, be cooled to 50 DEG C, add licorice extract, adjustment rotating speed is 2800r/min, homogeneous 3min,
It is cooled to 35 DEG C.
Embodiment 2
A kind of Radix Glycyrrhizae emulsifiable paste contains the following components of mass parts: licorice extract 30 parts, Dormant oils 20 parts, polydimethylsiloxanes
30 parts of alkane, white pond flower seed oil 22 parts, caprylic/capric triglyceride 42 parts, agar stearic acid 40 parts, stearine and
PEG-100 stearate 40 parts, glycerine 40 parts, laruyl alcohol sodium sulfovinate 5 parts, methyl hydroxybenzoate and propylben (3:
1) mixing preservative 3 parts and distilled water 1000 parts；
The preparation method of licorice extract is: Radix Glycyrrhizae is put clean draining, is placed in drying box, dries to constant weight at 60 DEG C,
Pulverizing, cross 40 mesh sieves, use ultrasonic extraction, extracting liquorice powder 20g, solvent is 65% ethanol 180ml, at power is
100W, frequency is 20kHz, under the conditions of temperature is 40 DEG C, carries out ultrasonic extraction 30min, is refluxed three times by licorice,
Filter, be condensed into 1/10th of original volume.
The preparation method of Radix Glycyrrhizae emulsifiable paste comprises the steps of aqueous phase and the oil phase weighing mass parts, heats respectively and stir at 95 DEG C
Mixing in homogeneously, insulation is at about 80 DEG C, and in the aqueous phase stirred adds oil phase, in the same direction, limit edged is with rotating speed
Stirring for 20r/min, after 30min, be cooled to 50 DEG C, add licorice extract, adjustment rotating speed is 2800r/min, homogeneous 3min,
It is cooled to 45 DEG C.
Embodiment 3
A kind of Radix Glycyrrhizae emulsifiable paste contains the following components of mass parts: licorice extract 25 parts, Dormant oils 18 parts, polydimethylsiloxanes
26 parts of alkane, white pond flower seed oil 20 parts, caprylic/capric triglyceride 41 parts, agar stearic acid 36 parts, stearine and
PEG-100 stearate 37 parts, glycerine 35 parts, laruyl alcohol sodium sulfovinate 4 parts, methyl hydroxybenzoate and propylben (3:
1) mixing preservative 2 parts and distilled water 950 parts；
The preparation method of licorice extract is: Radix Glycyrrhizae is put clean draining, is placed in drying box, dries to constant weight at 55 DEG C,
Pulverizing, cross 40 mesh sieves, use ultrasonic extraction, extracting liquorice powder 20g, solvent is 65% ethanol 180ml, at power is
100W, frequency is 20kHz, under the conditions of temperature is 38 DEG C, carries out ultrasonic extraction 15min, is refluxed three times by licorice,
Filter, be condensed into 1/10th of original volume.
The preparation method of Radix Glycyrrhizae emulsifiable paste comprises the steps of aqueous phase and the oil phase weighing mass parts, heats respectively and stir at 95 DEG C
Mixing in homogeneously, insulation is at about 78 DEG C, and in the aqueous phase stirred adds oil phase, in the same direction, limit edged is with rotating speed
Stirring for 20r/min, after 30min, be cooled to 50 DEG C, add licorice extract, adjustment rotating speed is 2800r/min, homogeneous 3min,
It is cooled to 40 DEG C.
Claims (3)
1. a Radix Glycyrrhizae emulsifiable paste, it is characterised in that it contains the following components of mass parts: licorice extract 20～30 parts, Dormant oils 15～20
Part, dimethyl silicone polymer 25～30 parts, white pond flower seed oil 18～22 parts, caprylic/capric triglyceride 40～42 parts, agar hard
Resin acid 35～40 parts, stearine and PEG-100 stearate 35～40 parts, glycerine 30～40 parts, laruyl alcohol sulfuric ester
Sodium 2～5 parts, methyl hydroxybenzoate and propylben (3:1) mixing preservative 1～3 parts and distilled water 900～1000 parts.
A kind of Radix Glycyrrhizae emulsifiable paste the most according to claim 1, it is characterised in that the preparation method of described Radix Glycyrrhizae emulsifiable paste comprises following
Step: weigh aqueous phase and the oil phase of mass parts, adds thermal agitation respectively at 95 DEG C extremely in homogeneously, is incubated at about 75～80 DEG C,
Adding in oil phase by the aqueous phase stirred, in the same direction, limit edged stirs with rotating speed for 20r/min, after 30min, and cooling
To 50 DEG C, adding licorice extract, adjustment rotating speed is 2800r/min, and homogeneous 3min is cooled to 35～45 DEG C.
A kind of Radix Glycyrrhizae emulsifiable paste the most according to claim 1 and 2, it is characterised in that: the preparation method of described licorice extract is:
Put Radix Glycyrrhizae to clean and drain, be placed in drying box, dry at 50～60 DEG C to constant weight, pulverize, cross 40 mesh sieves, use ultrasonic
Ripple extraction method, extracting liquorice powder 20g, solvent is 65% ethanol 180ml, is 100W at power, and frequency is 20kHz, in temperature
Under the conditions of degree is 35～40 DEG C, carry out ultrasonic extraction 10～30min, licorice is refluxed three times, filter, be condensed into substance
Long-pending 1/10th.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610135527.4A CN105748573A (en) | 2016-03-10 | 2016-03-10 | Radix Glycyrrhizae cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610135527.4A CN105748573A (en) | 2016-03-10 | 2016-03-10 | Radix Glycyrrhizae cream and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105748573A true CN105748573A (en) | 2016-07-13 |
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| CN201610135527.4A Withdrawn CN105748573A (en) | 2016-03-10 | 2016-03-10 | Radix Glycyrrhizae cream and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159545A (en) * | 2021-12-29 | 2022-03-11 | 北京远胜达生物科技发展有限公司 | Whitening anti-wrinkle composition containing enzyme and application of composition in medicines |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
| CN103520328A (en) * | 2013-10-31 | 2014-01-22 | 天津中医药大学 | Compound traditional Chinese medicine acne gel and preparation method thereof |
-
2016
- 2016-03-10 CN CN201610135527.4A patent/CN105748573A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
| CN103520328A (en) * | 2013-10-31 | 2014-01-22 | 天津中医药大学 | Compound traditional Chinese medicine acne gel and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 魏宁: "甘草乳膏的制备工艺与质量标准研究", 《中国优秀硕士学位论文全文数据库(医药卫生科技辑)》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114159545A (en) * | 2021-12-29 | 2022-03-11 | 北京远胜达生物科技发展有限公司 | Whitening anti-wrinkle composition containing enzyme and application of composition in medicines |
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Application publication date: 20160713 |