CN1234388C - External-use medicinal composition for treating gall - Google Patents
External-use medicinal composition for treating gall Download PDFInfo
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- CN1234388C CN1234388C CN 02158235 CN02158235A CN1234388C CN 1234388 C CN1234388 C CN 1234388C CN 02158235 CN02158235 CN 02158235 CN 02158235 A CN02158235 A CN 02158235A CN 1234388 C CN1234388 C CN 1234388C
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- schefflerae arboricolae
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Abstract
The present invention relates to a medicinal composition for treating galls, particularly to an external medicinal composition for treating galls, which is prepared form vegetal Chinese herbal medicine. The medicinal composition of the present invention comprises the following raw materials with the weight proportioning: 72 to 288 grams of scandent schefflera roots, 72 to 288 grams of delivery ampelopsis roots, 72 to 288 grams of yunnan craibiodendron leaves, 72 to 288 grams of tali falsehellebore herb, and 72 to 288 grams of tuniclike psammosilene roots. A toxicity test is carried out to prove that the medicinal composition can be used externally without toxic and side effects; the medicinal composition is researched by pharmacodynamics to present obvious functions for resisting inflammation, alleviating pain, improving microcirculation, inhibiting gouty arthritis and inhibiting hyperplasia of mammary glands. The medicinal composition is used clinically to prove that the total effective rate of the medicinal composition for treating diseases, such as traumatic injury, rheumatic arthritis, periarthritis humeroscapularis, gout, hyperplasia of lobuli glandulae mammariae, etc., can reach more than 90%.
Description
Technical field
The present invention relates to the pharmaceutical composition that a kind of treatment is swollen and ache, particularly relate to the externally-applied medicinal composition that a kind of treatment that with the vegetable Chinese herbal medicine is raw material is made is swollen and ache.
Background technology
Chinese patent application numbers 931112052 discloses " a kind of compound method of burn-scald medicine ", is to place ethanol to soak Radix Sanguisorbae, Cortex Phellodendri, elm endothelium and/or jujube tree endothelium, Borneolum Syntheticum and Radix Notoginseng to be mixed with the burn and scald medicinal liquid.Described medical material the ratio of each component is: Radix Sanguisorbae 70-100 part, Cortex Phellodendri 50-100 branch, elm endothelium and/or jujube tree endothelium 1-60 part, Borneolum Syntheticum 0.1-2 part, Radix Notoginseng 0.1-2 part.
Summary of the invention
Purpose of the present invention is intended to provide a kind of traumatic injury wound, rheumatism externally-applied medicinal composition evident in efficacy, safe in utilization for the treatment of.
The externally-applied medicinal composition that treatment of the present invention is swollen and ache is the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288
In above-mentioned composition, also can contain weight proportion Radix et Rhizoma Dysosmatis 72-288, Rhizoma Paridis 72-288, Radix Notoginseng 72-288, Fructus Gardeniae 72-288, Radix Glycyrrhizae 24-96, Pseudobulbus Bletillae (Rhizoma Bletillae) 72-288, Radix Angelicae Dahuricae 72-288.Fructus Gardeniae wherein can substitute with Radix Salviae Miltiorrhizae.
The present invention is principal agent with the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), and the sweet temperature of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) is arrogated to oneself alleviating pain and detumescence, relaxing muscles and tendons and activating QI and blood in the collateral, and expelling wind and removing dampness is used for various pain, injury and bone fracture and traumatic hemorrhage; Radix Psammosilenes, Delavay ampelopsis root, Folium Craibiodendri Yunnanensis all are the diffusing product of warm suffering, have the merit of inspiring personal yang-energy, immerse in an opponent's defence between the meridians joint and the wind-cold damp pathogen gas that do not go of residence for a long time to disperse, and the effect of eliminating stasis to stop pain is arranged; Rhizoma Paridis, Radix et Rhizoma Dysosmatis, Herba Veratri Taliensis nature and flavor bitter cold, be good at heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, red and swollen heat pain for pyretic arthralgia and traumatic injury and cyclomastopathy has direct removing heat from blood and promoting blood circulation, reducing swelling and alleviating pain effect, and can prevent medicine consumption impairment of QI the moon that the hot temperature of loosing is logical, be total to the assosting effect that opposes each other and yet also complement each other merit with enhancing principal agent tonneau passages through which vital energy circulates, reducing swelling and alleviating pain.Fructus Gardeniae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) are adjuvant drug, Fructus Gardeniae, Pseudobulbus Bletillae (Rhizoma Bletillae) bitter cold, can restrain the property of warm drugs impairment of YIN dryness-transformation and receive the assistant system effect; Fructus Gardeniae also can cool the blood dissipate blood stasis on the other hand, and the phlegmatic temperament of Pseudobulbus Bletillae (Rhizoma Bletillae) can make the little apparent thickness of medicinal liquid, plays the medicine carrying effect.The Radix Angelicae Dahuricae is antipruritic, can prevent the diseases such as pruritus that may occur after a few peoples' medication.Radix Glycyrrhizae can heat-clearing and toxic substances removing, relieving spasm to stop pain, can be in harmonious proportion the cold and heat property of medicine again, relaxes the toxicity of medicine and strong, is messenger drug.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) of the present invention is the dry Herb of Araliaceae Schefflera venulosa (Wight et Arn.) Harms Schefflera venulosa Wightet Arn., is stated from " Yunnan Province's drug standard " 1996:3; Delavay ampelopsis root is the dry root of beautiful Fructus Vitis viniferae Ampelopsis delavayana (French.) Planch. of vitaceae, is stated from " 1977:127 of Chinese pharmacopoeia and " Yunnan Province's drug standard " 1996:36; Folium Craibiodendri Yunnanensis is the dried leaves of the plant Folium Craibiodendri Yunnanensis Craibiodendronyunnanense W.W.Smith of Photiniaserrulata section, is stated from " national medical material (Yi nationality's medicine) standard in Yunnan Province "; Herba Veratri Taliensis is the dry root and rhizome of liliaceous plant Dali Rhizoma et radix veratri (Radix Rhizoma Veratri) Veratrum taliense Loes f, is stated from " Yunnan Province's drug standard " 1996:67; Radix Psammosilenes is the dry root of pinkwort Radix Psammosilenes Psammosilenetunicoides W.C.Wu.et C.Y.wu, is stated from " 1977:362 of Chinese pharmacopoeia and " Yunnan Province's drug standard " 1996:73; Radix et Rhizoma Dysosmatis is the dry root stock of Berberidaceae plant Radix et Rhizoma Dysosmatis Dysosmaversipellis (Hance) M.Cheng, be stated from " Guangxi Chinese crude drug standard " 1990:4: Rhizoma Paridis is the dry rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Smith var.yunnanensis (Franch.) Hand.-Mazz. or Rhizoma Paridis Paris polyphylla Smith var chinensis (Franch) Hara, is stated from " 2000:214 of Chinese pharmacopoeia; Radix Notoginseng is the dry root of panax araliaceae plant Panax notoginseng (Burk) F H Chen, is stated from " 2000:10 of Chinese pharmacopoeia; Pseudobulbus Bletillae (Rhizoma Bletillae) is the dry tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thunb) Reichb.f., is stated from " 2000:76 of Chinese pharmacopoeia; The Radix Angelicae Dahuricae is the dry root of samphire Radix Angelicae Dahuricae Angelicadahurica (Fisch.ex Hoffm.) Benth.et Hook.f or Radix angelicae dahuricae Angelicadahurica (Fisch.ex.Hoffm) Benth.et.Hook.f.var.formosana (Boiss) Shah etYuan, is stated from " 2000:79 of Chinese pharmacopoeia; Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch. Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L., is stated from " 2000:65 of Chinese pharmacopoeia; Fructus Gardeniae is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae Gardenia jasminoides Ellis, is stated from " 2000:201 of Chinese pharmacopoeia.
Medicament of the present invention is a said exterior-applied formulation on the pharmaceutics.Can be the liniment made through conventional technology of raw material of the present invention and corresponding medicinal adjuvant, aerosol, liniment, rubber-emplastrum, cataplasma etc.
Pharmaceutical composition of the present invention has no side effect through the external of toxicity test proof; The effect that has significant antiinflammatory, analgesia, microcirculation improvement, inhibition gouty arthritis and inhibition cyclomastopathy through pharmacodynamic study; Through clinical trial, treatment of diseases total effective rates such as traumatic injury, rheumatic arthritis, scapulohumeral periarthritis, gout and cyclomastopathy are reached more than 90%.Be specially:
Toxicological study:
1, enepidermic acute toxicity and irritation test
Result: part rabbit damaged skin wound is produced slight erythema, but do not find that epiderm skin and corium have any pathological changes, behavioral activity, hair luster, eye and the mucosa of rabbit, breathing, central nervous system etc. are all had no effect.Observation period finishes, and animal all survives, weight increase.To rabbit intact skin nonirritant, be slight zest to damaged skin.
2, skin allergy test
Result: guinea pig skin is not had anaphylaxis.
3, long term toxicity test
Do not see that the toxicity variation of outward appearance, body weight gain, hemogram, blood biochemical and 15 kinds of organs and tissues appears in animal.
Pharmacodynamic study
1, antiinflammatory action research
(1) influence of rat assist agent arthritis
The result: can suppress the primary affection of rat assist agent arthritis, offside foot swelling when obviously suppressing secondary affection and foot swelling once again, the General Symptoms when alleviating delayed hypersensitivity does not have obvious influence to immune organ, adrenal gland's weight and body weight.
(2) to the influence of rat Ovum Gallus domesticus album foot swelling
Result: the pedal swelling that significantly suppresses rat due to the Ovum Gallus domesticus album.
(3) xylol causes the influence of mice auricle swelling.
Result: significantly suppress the mice caused by dimethylbenzene xylene auricle edema.
2, analgesic activity research
(1) the Dichlorodiphenyl Acetate induced mice is turned round the influence of body pain.
Result: significantly suppress the writhing response that acetic acid causes the pain mice.
(2) mice formaldehyde is caused the influence that pain is reacted
The result: mice formaldehyde is caused the pain reaction remarkable inhibitory action.
3, to the influence of experimental microcirculation disturbance
Result: the arteriole, venule caliber and the capillary network counting that obviously increase experimental microcirculation disturbance mice due to the epinephrine.
4, the arthritic effect of gout
To the bullate influence of uric acid sodium inducing mouse foot
Result: to the antiinflammatory action highly significant of mice gouty arthritis.
Uric acid sodium is induced the bullate influence of rat foot
Result: to the antiinflammatory action highly significant of rat gouty arthritis.
5, to the influence of cyclomastopathy
Influence to diethylstilbestrol induced mice cyclomastopathy
The result: the mice cyclomastopathy that significantly suppresses diethylstilbestrol and caused alleviates lesion degree.
To the outgrowth influence of rat mammary gland due to the diethylstilbestrol
The result: the rat breast that significantly suppresses diethylstilbestrol and caused increases, and alleviates the breast lesion degree.
Clinical research:
Observation adopts independent medication to verify to the clinical efficacy of diseases such as traumatic injury (soft tissue injury), rheumatic arthritis, scapulohumeral periarthritis, gout and cyclomastopathy.
Traumatic injury group (soft tissue injury): obvious effective rate 86.86%; Effective percentage 11.68%; Inefficiency 1.46%; Total effective rate 98.54%.
Rheumatic arthritis group: obvious effective rate 60.40%; Effective percentage 28.71%; Inefficiency 10.89%; Total effective rate 89.11%.
Scapulohumeral periarthritis group: obvious effective rate 69.47%; Effective percentage 28.42%; Inefficiency 2.11%; Total effective rate 97.89%.
Gout group: obvious effective rate 55.56%; Effective percentage 38.38%; Inefficiency 6.06%; Total effective rate 93.94%.
Cyclomastopathy group: obvious effective rate 46.67%; Effective percentage 43.81%; Inefficiency 9.52%; Total effective rate 90.48%.
The specific embodiment
Embodiment 1:
Get Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 150, Delavay ampelopsis root 200, Folium Craibiodendri Yunnanensis 110, Herba Veratri Taliensis 220, Radix Psammosilenes 100, Radix Glycyrrhizae 50, Radix Notoginseng 130, the Radix Angelicae Dahuricae 100, Fructus Gardeniae 180 is ground into coarse powder, mixing with said medicine, soaks into finite concentration ethanol, percolation is collected the liquid of filtering, and cold preservation is filtered, packing, promptly.
Embodiment 2:
Get Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 190, Delavay ampelopsis root 130, Folium Craibiodendri Yunnanensis 120, Herba Veratri Taliensis 250, Radix Psammosilenes 230, Rhizoma Paridis 150, Radix Glycyrrhizae 80, Radix Notoginseng 150, Pseudobulbus Bletillae (Rhizoma Bletillae) 100, said medicine is ground into coarse powder, mixing, soaks into percolation with finite concentration ethanol, the collection liquid of filtering, cold preservation is filtered, place, behind adding tween, propylene glycol and the medicinal liquid mixing, leave standstill.Medicinal liquid is poured in the clean container, be pressed into third butane gas with pressing machine, promptly.
Embodiment 3:
Get Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 220, Delavay ampelopsis root 150, Folium Craibiodendri Yunnanensis 150, Herba Veratri Taliensis 180, Radix Psammosilenes 140, Rhizoma Paridis 120, Radix Notoginseng 200, Radix et Rhizoma Dysosmatis 190 is ground into coarse powder, mixing with said medicine, soaks into finite concentration ethanol, and percolation is collected the liquid of filtering, and cold preservation is filtered, and is standby.Getting it filled adds standby medicinal liquid with film resin, stir, and the room temperature swelling, heating in water bath makes dissolving, and adding glycerol is an amount of, stirs, packing, promptly.
Claims (8)
1, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288.
2, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Radix et Rhizoma Dysosmatis 72-288.
3, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Rhizoma Paridis 72-288.
4, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Radix Notoginseng 72-288.
5, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Fructus Gardeniae 72-288.
6, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Radix Glycyrrhizae 24-96.
7, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Pseudobulbus Bletillae (Rhizoma Bletillae) 72-288.
8, the externally-applied medicinal composition that swells and ache of a kind of treatment is characterized in that it being the medicament of being made by the following weight proportion raw material:
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 72-288 Delavay ampelopsis root 72-288 Folium Craibiodendri Yunnanensis 72-288
Herba Veratri Taliensis 72-288 Radix Psammosilenes 72-288 Radix Angelicae Dahuricae 72-288.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 02158235 CN1234388C (en) | 2002-12-18 | 2002-12-18 | External-use medicinal composition for treating gall |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 02158235 CN1234388C (en) | 2002-12-18 | 2002-12-18 | External-use medicinal composition for treating gall |
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CN1507915A CN1507915A (en) | 2004-06-30 |
CN1234388C true CN1234388C (en) | 2006-01-04 |
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CN 02158235 Expired - Lifetime CN1234388C (en) | 2002-12-18 | 2002-12-18 | External-use medicinal composition for treating gall |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103830514A (en) * | 2014-03-27 | 2014-06-04 | 贵州维康药业有限公司 | Externally-used patch for treating gout and preparation method thereof |
CN104352642A (en) * | 2014-11-13 | 2015-02-18 | 宋爱民 | Externally-applied traditional Chinese medicine tincture for treating knee-joint acute traumatic synovitis |
CN108186825A (en) * | 2018-03-07 | 2018-06-22 | 黄振忠 | A kind of drug for treating gout |
CN114634537A (en) * | 2022-04-12 | 2022-06-17 | 云南省药物研究所 | Preparation method and application of diterpene in gold leaves |
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2002
- 2002-12-18 CN CN 02158235 patent/CN1234388C/en not_active Expired - Lifetime
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