CN103830514A - Externally-used patch for treating gout and preparation method thereof - Google Patents
Externally-used patch for treating gout and preparation method thereof Download PDFInfo
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- CN103830514A CN103830514A CN201410117377.5A CN201410117377A CN103830514A CN 103830514 A CN103830514 A CN 103830514A CN 201410117377 A CN201410117377 A CN 201410117377A CN 103830514 A CN103830514 A CN 103830514A
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Abstract
The invention discloses an externally-used patch for treating gout and a preparation method of the patch. The patch is prepared from typhonium giganteum, matrixes, a piece of single-side release paper and a non-woven cloth ointment patch. The preparation method comprises the following steps: firstly, crushing the typhonium giganteum, further mixing the typhonium giganteum powder with matrixes such as sensitive adhesive to prepare the ointment, further coating the ointment on the single-side release paper, drying, cutting into corresponding shapes and sizes, and further adhering to the non-woven ointment patch so as to obtain the patch. The patch has the advantages of good curative effect, no toxic or side effect, convenience in application and the like.
Description
Technical field
The present invention relates to a kind of preparation method of external use plaster for the treatment of gout, belong to the technical field of medicine, health product.
Background technology
Gout is because uric acid in body is too high, directly causes experimental study, and main manifestations is osteoarthrosis position redness, has an intense pain as the acute joint disease characterizing.Hurt like hell when outbreak is although oral drug is as the energy such as colchicine, allopurinol tablet quickly alleviating pain, large to Liver and kidney side effect.Gout thoroughly can not cause arthroncus, deformity, stiff, periarticular ecchymosis, tuberosity, concurrent gouty renal calculus, gouty renal failure as controlled, the zang-fu diseases such as gouty coronary heart disease, hyperlipidemia, hypertension, urinary system calculus, serious threat patients ' life quality and life.
This product is mainly carried out reducing swelling and alleviating pain for gouty arthritis exactly, reaches the object for the treatment of gout.In side, Typhonium divaricatum (L.) Decne has effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the arresting convulsion of cool liver, for furuncle carbuncle, and laryngopharynx swelling and pain, snake bite and insect sting, falls and flutters the pain of injury, convulsion with spasms.The gout that is used for the treatment of among the people, evident in efficacy.We are medicine for external use, good effect, and side effect is little.
Summary of the invention
This gout is pasted and is mainly made up of Typhonium divaricatum (L.) Decne, substrate, one side release paper and non-woven fabrics plaster.There is effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Can be used for the wind-induced joint congestion and swelling pain of pain, myalgia.Typhonium divaricatum (L.) Decne in we is that title is commonly used in place, and real is the dry rhizome of Bai He section plant Herba Veronicae Persicae, and excavate autumn, removes fibrous root, cleans, and dries.Record in going through portion's " Chinese Pharmacopoeia ", pharmacopeia is called Rhizoma Paridis.
The preparation method that this gout is pasted is as follows:
A, Typhonium divaricatum (L.) Decne is crushed to 80 ~ 200 orders, for subsequent use, obtain a product;
B, one or more in quick Asia glue, Oleum menthae, Oleum Sesami, Oleum sesami, Oleum Eucalypti, azone, glycerol, sodium benzoate, potassium sorbate are mixed, make substrate for subsequent use, obtain b product;
C, get a product and b product mix homogeneously, regulate relative density to 1.1 ~ 1.5, make ointment for subsequent use, obtain C product;
D, c product are coated in one side release paper, dried, be cut into respective shapes and size, then be affixed on non-woven fabrics plaster, get product.
The present invention is on folk remedy basis, by repeatedly experiment, research summary, the external use plaster of the treatment gout developing.This dosage form, compared with former indigenous method, all has a clear superiority on using method, bioavailability, medicine stability, and former indigenous method is that Typhonium divaricatum (L.) Decne fresh goods is mashed, and is coated on affected part; Or Typhonium divaricatum (L.) Decne dry product is ground into fine powder, become pasty state with water-wet, be coated on affected part.The party's good effect, but be not easy to use, on the one hand, it is bad that ordinary people measures grasp, on the other hand, and the easy pollution clothes of medicinal residues.In order to overcome the above problems, my company has carried out a large amount of technical studies to the party, has been developed into the patch for the treatment of gout.Patch is external preparation, directly acts on affected part, rapid-action, and toxic and side effects is little, and has added cutaneous permeable agent in patch, is more conducive to drug absorption, and experimental result sees the following form:
In addition, it is as follows that this gout is pasted treatment gout clinical efficacy:
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Gout is pasted | 25 | 15 | 8 | 2 | 92% |
| Matched group (directly mashing external application) | 18 | 11 | 5 | 2 | 89% |
From experimental result, this gout is pasted curative effect and is better than matched group, and total effective rate reaches 92%, may be conducive to due to the cutaneous permeable agent adding the absorption of medicine, thereby reach good therapeutic purposes.
Specific embodiment:
Specific embodiment 1, get 500g Typhonium divaricatum (L.) Decne medical material, pulverize, cross 100 orders, for subsequent use; Quick Asia glue 400g, Oleum menthae 15g, sodium benzoate 2.5g are mixed, make substrate for subsequent use; Unipods Nelumbo nucifera Gaertn. Powder and substrate are mixed, adjusting relative density is 1.2 ~ 1.4, makes ointment again; Finally ointment is applied in preprepared one side release paper, dries, being cut into diameter is the circular patch of 5cm, then is affixed on non-woven fabrics plaster, to obtain final product.
Specific embodiment 2, get 200g Typhonium divaricatum (L.) Decne medical material, pulverize, cross 150 orders, for subsequent use; Quick Asia glue 200g, Oleum Eucalypti 10g, potassium sorbate 0.2g are mixed, make substrate for subsequent use; Unipods Nelumbo nucifera Gaertn. Powder and substrate are mixed, adjusting relative density is 1.2 ~ 1.4, makes ointment again; Finally ointment is applied in preprepared one side release paper, dries, being cut into diameter is the circular patch of 4cm, then is affixed on non-woven fabrics plaster, to obtain final product.
Specific embodiment 3, get 800g Typhonium divaricatum (L.) Decne medical material, pulverize, cross 120 orders, for subsequent use; Quick Asia glue 1000g, azone 30g, potassium sorbate 0.8g are mixed, make substrate for subsequent use; Unipods Nelumbo nucifera Gaertn. Powder and substrate are mixed, adjusting relative density is 1.2 ~ 1.4, makes ointment again; Finally ointment is applied in preprepared one side release paper, dries, being cut into the length of side is the square patch of 6cm, then is affixed on non-woven fabrics plaster, to obtain final product.
Specific embodiment 4, get 1000g Typhonium divaricatum (L.) Decne medical material, pulverize, cross 200 orders, for subsequent use; Quick Asia glue 1000g, glycerol 35g, Nipagin ester 1g are mixed, make substrate for subsequent use; Unipods Nelumbo nucifera Gaertn. Powder and substrate are mixed, adjusting relative density is 1.2 ~ 1.4, makes ointment again; Finally ointment is applied in preprepared one side release paper, dries, being cut into the length of side is the square patch of 6cm, then is affixed on non-woven fabrics plaster, to obtain final product.
Claims (7)
1. an external use plaster for the treatment of gout, is characterized in that: be made up of Typhonium divaricatum (L.) Decne, substrate, one side release paper and non-woven fabrics plaster.
2. external use plaster according to claim 1, is characterized in that: described external use plaster preparation method is as follows:
A, Typhonium divaricatum (L.) Decne is crushed to 80 ~ 200 orders, for subsequent use, obtain a product;
B, one or more in quick Asia glue, cutaneous permeable agent, antiseptic are mixed, make substrate for subsequent use, obtain b product;
C, get a product and b product mix homogeneously, regulate relative density to 1.1 ~ 1.5, make ointment, obtain C product;
D, c product are coated in one side release paper, dried, be cut into respective shapes and size, then be affixed on non-woven fabrics plaster, the gout that gets product is pasted.
3. external use plaster according to claim 1 and 2, is characterized in that: described Typhonium divaricatum (L.) Decne weight portion is 200g ~ 2000g, makes 1000 subsides.
4. external use plaster according to claim 1 and 2, it is characterized in that: described cutaneous permeable agent is one or more in Oleum menthae, Oleum Sesami, Oleum sesami, Oleum Eucalypti, azone, glycerol, described antiseptic is one or more in benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, Nipagin ester.
5. external use plaster according to claim 1 and 2, is characterized in that: described circle, ellipse, square, the rectangle of being shaped as.
6. according to the external use plaster described in any one in claim 1 ~ 5, it is characterized in that: every patch weight is 1 ~ 4g.
7. according to the external use plaster described in any one in claim 1 ~ 5, it is characterized in that: described external use plaster has effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, can be used for the wind-induced joint congestion and swelling pain of pain, myalgia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410117377.5A CN103830514A (en) | 2014-03-27 | 2014-03-27 | Externally-used patch for treating gout and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410117377.5A CN103830514A (en) | 2014-03-27 | 2014-03-27 | Externally-used patch for treating gout and preparation method thereof |
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| CN103830514A true CN103830514A (en) | 2014-06-04 |
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| CN201410117377.5A Pending CN103830514A (en) | 2014-03-27 | 2014-03-27 | Externally-used patch for treating gout and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456272A (en) * | 2003-02-21 | 2003-11-19 | 邹为民 | Gouty ointment |
| CN1507915A (en) * | 2002-12-18 | 2004-06-30 | 云南省药物研究所 | External-use medicinal composition for treating gall |
| CN102406840A (en) * | 2011-11-18 | 2012-04-11 | 云南省药物研究所 | Swelling and pain gel paste and preparation method thereof |
-
2014
- 2014-03-27 CN CN201410117377.5A patent/CN103830514A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1507915A (en) * | 2002-12-18 | 2004-06-30 | 云南省药物研究所 | External-use medicinal composition for treating gall |
| CN1456272A (en) * | 2003-02-21 | 2003-11-19 | 邹为民 | Gouty ointment |
| CN102406840A (en) * | 2011-11-18 | 2012-04-11 | 云南省药物研究所 | Swelling and pain gel paste and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 何巧兰: "痛风贴外用及综合护理对痛风性关节炎患者整体病情及生活质量的影响", 《四川中医》, vol. 31, no. 1, 31 December 2013 (2013-12-31), pages 146 - 148 * |
| 钟世耀: "痛风辨治", 《山东中医杂志》, vol. 21, no. 11, 30 November 2002 (2002-11-30), pages 646 - 647 * |
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Application publication date: 20140604 |