CN104606373A - Girald daphne bark adhesive paste and preparation method thereof - Google Patents
Girald daphne bark adhesive paste and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a girald daphne bark adhesive paste. The adhesive paste is prepared from the following raw materials in parts by weight: 5-10 parts of a traditional Chinese medicine extract, 1-5 parts of an adhesive, 0.1-0.5 part of a filling agent, 0.1-0.5 part of a transdermal absorption enhancer, 5-15 parts of a moisturizing agent, 0.1-0.5 part of a crosslinking agent, 0.1-0.5 part of a crosslinking regulator, 0.1-0.5 part of a thickening agent and 15-20 parts of distilled water. Meanwhile, the invention also discloses a preparation method of the girald daphne bark adhesive paste. The girald daphne bark adhesive paste disclosed by the invention has the effects of resisting inflammation and easing pain, and can be applied to the treatment on rheumatism, rheumatoid diseases and swellings and pains caused by various reasons.
Description
Technical field
The present invention relates to a kind of external preparation, particularly relate to Daphne giraldii Nitsche gel ointment and preparation method thereof.
Background technology
Daphne giraldii Nitsche Cortex Daphnes is thymelaeceae (Thymelaeaceae) plant Daphne Giraldii Nitsche
daphne giraldiinitsche, Gansu winter daphne (the sweet winter daphne in Shan, Tang Gute winter daphne)
daphne tanguticamaxim and retuseleaf daphne bark
daphne retusathe dry root bark of Hemsl and peel of stem, mainly originate from the ground such as Gansu, Shaanxi, Yunnan, Sichuan, Tibet, Qinghai.Daphne giraldii Nitsche begins to be loaded in " Shaanxi Chinese herbal medicine ", acrid, bitter, warm; Slightly poisonous; Return Liver Channel, there is expelling wind and removing dampness, promoting blood circulation and stopping pain effect, be commonly called as " beating ground swashes; be unable to do without Daphne giraldii Nitsche ", (State Administration of Traditional Chinese Medicine's " China's book on Chinese herbal medicine " editorial board " Daphne giraldii Nitsche China book on Chinese herbal medicine " such as disease such as treatment pain, traumatic injury etc. is widely used in by among the people, 1999,5th volume: 407).
The Chinese medicine preparation be made up of Daphne giraldii Nitsche processing of crude drugs by route of administration be divided into oral, injection, external three class, oral formulations relates generally to tablet, capsule, slow-release micro-pill, wherein Giraldi daphne tablet is by the tablet of Daphne giraldii Nitsche extract powder through being processed into, expelling wind and removing dampness, promoting blood circulation and stopping pain, be used for the treatment of rheumatic Bi syndrome, arthritis, rheumatoid arthritis (Chinese Pharmacopoeia Commission's " Giraldi daphne tablet version Chinese Pharmacopoeia () in 2010 ", 2010:971-972); Daphne Capsules be by Giraldi daphne tablet dosage changing form form (Chen Bo, Wang Wan, former Fructus Pyracanthae wait " and the content of Daphnetin in Zushima Capsules by HPLC. time precious traditional Chinese medical science traditional Chinese medicines ", 2006,17 (3): 366-367); Daphne giraldii Nitsche total coumarin slow-release micro-pill take Daphne giraldii Nitsche total coumarin as raw material, adopt solution medicine-feeding legal system for micropill, and choose surelease aqueous dispersion and carry out slow-release micro-pill (Zhang Xinzhuan prepared by film-controlled slow-release coating, Di Liuqing, singly march, Deng " preparation of Daphne giraldii Nitsche total coumarin slow-release micro-pill and release characteristics Journal of Chinese Hospital Pharmacy ", 2010,30 (11): 891-894).Injection has 4 kinds, Daphne giraldii Nitsche injection respectively, Daphne Giraldii Nitsche injection, daphne freeze-drying powder and compound recipe Daphne giraldii Nitsche injection liquid, wherein Daphne giraldii Nitsche injection is root bark and the sterile water solution of peel of stem through being processed into (Chinese Pharmacopoeia Commission's " Daphne giraldii Nitsche injection Drug Standard of Ministry of Public Health of the Peoples Republic of China the 20th " of Isolated From Thymelaeaceae Species Daphne Giraldii Nitsche, 1998:235), and be the sterile water solution (Chinese Pharmacopoeia Commission's " Daphne Giraldii Nitsche injection Drug Standard of Ministry of Public Health of the Peoples Republic of China the 13rd " 1997:333) made through vapor distillation with the Daphne Giraldii Nitsche injection that same raw material Daphne Giraldii Nitsche is made, the preparation technology of the two is different, but function cures mainly close, all there is expelling wind and removing dampness, the function of promoting blood circulation and stopping pain, be mainly used in rheumatic arthritis, rheumatoid arthritis belongs to above-mentioned patient, the lyophilized injectable powder that daphne freeze-drying powder injection is made with the extract of the root bark of Daphne giraldii Nitsche and peel of stem, be mainly used in treatment limbs to swell and ache or the disease such as twinge, cold type of pain (fourth nail raw " a kind of daphne freeze-drying powder injection and preparation method thereof Chinese patent ", 200510056446.7.2006-09-27), compound recipe Daphne giraldii Nitsche injection liquid is primarily of Daphne giraldii Nitsche, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis composition, clinical efficacy is (Li Gao, Li Jizhen, Xie Jingwen " preparation technology of compound recipe Daphne giraldii Nitsche injection liquid and quality control method CHINA JOURNAL OF CHINESE MATERIA MEDICA " significantly, 1992,17 (11): 664-665).External preparation relates generally to plaster, gel ointment, spray, spirit, wherein Zushima gaoyao (Chinese Pharmacopoeia Commission's " Zushima gaoyao Drug Standard of Ministry of Public Health of the Peoples Republic of China the 18th ", 1998:233) be made up of the extract powder of Daphne giraldii Nitsche Hydrolysis kinetics and Wuwei plaster, belong to traditional black plaster, the function of tool expelling wind and removing dampness, promoting blood circulation and stopping pain, for anemofrigid-damp arthralgia, Yu Xue Bi resistance passages through which vital energy circulates.Disease is seen: limbs joint swells and ache, aversion to cold and cold limbs, local swelling, has scleroma or ecchymosis; Daphne giraldii Nitsche pain-relieving plaster for arthritis (Chinese Pharmacopoeia Commission's " Daphne giraldii Nitsche pain-relieving plaster for arthritis Drug Standard of Ministry of Public Health of the Peoples Republic of China the 18th, 1998:231) based on Daphne giraldii Nitsche, add the modern rubber plaster that Camphora, Borneolum Syntheticum etc. are made, function cures mainly with Zushima gaoyao close; Compound preparation Daphne giraldii Nitsche rheumatism plaster (National Drug Administration's " compound preparation Daphne giraldii Nitsche rheumatism plaster country's standard for traditional Chinese medicines compilation (Chinese patent medicine provincial standard rising national standard part): orthopaedics fascicle ", 2002:415-418) by Daphne giraldii Nitsche, Radix Angelicae Sinensis, Rhizoma Cyperi, Radix Paeoniae Rubra, Borneolum Syntheticum etc. 24 taste Chinese medicine formula form through extracting processing and the external use plaster made, belong to traditional black plaster, clinically be mainly used in bones and muscles pain, numb limbs and tense tendons, lumbocrural pain, Fengshi Guanjie clock pain and muscles and bones strain, pain, fiber crops, swollen all diseases after traumatic injury; Daphne giraldii Nitsche gel ointment (Xie Xuehu, Zhao Zhengbao " the quality standard research China medicine and clinical of Daphne giraldii Nitsche cataplasma ", 2011,11 (1): 20-22), (Xie Xuehu, Shen Yongzheng, Zhao Zhengbao " the substrate prescription preparation of the preferred Daphne giraldii Nitsche cataplasma of orthogonal design and technology ", 2010,34 (7): 52-53) be the dosage form job change of Daphne giraldii Nitsche rheumatism plaster; Daphne giraldii Nitsche pain-easing spray (Zhao Xinghong, He Jiatian, Xu Honghai, Deng " preparation technology's Chinese Journal of New Drugs of Daphne giraldii Nitsche pain-easing spray ", 2012,21 (21): 2562-2565) be made up of Daphne giraldii Nitsche, Radix Angelicae Sinensis, Rhizoma Zingiberis Recens, Flos Caryophylli, Cortex Cinnamomi, Radix Glycyrrhizae, it is the novel preparation capable of permeating skin adopting the Percutaneous absorption enhancer of modern comparative maturity to research and develop, there is blood circulation promoting and blood stasis dispelling, exempt from numbness pain relieving, expelling wind and removing dampness effect, be used for the treatment of the traumatic injury of stagnation of QI and blood, soft tissue contusion, the diseases such as skin muscles and bones swelling pain; Daphne giraldii Nitsche fine wine (Xia Lingqing, Wang Chunyi " the practical tcm internal medicine magazine of Daphne giraldii Nitsche spirit external application for curing acute gouty arthritis ", 2007,21 (5): 6-7) be by the Daphne giraldii Nitsche root bark of drying section 200g, be placed in 75% ethanol 1000ml, sealing, rock 1 ~ 2 every day, leach medicinal liquid subpackage after 7 days for subsequent use, be mainly used in treating acute gouty arthritis, achieve significant curative effect.But have no the relevant report that alone Daphne giraldii Nitsche and Daphne giraldii Nitsche add the gel ointment of Radix Lamiophlomidis Rotatae.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of utilize Chinese medicine theoretical, there is the treatment rheumatic arthritis of inner disease outer treat function, the Daphne giraldii Nitsche gel ointment of rheumatoid arthritis.
Another technical problem to be solved by this invention is to provide the preparation method of this Daphne giraldii Nitsche gel ointment.
For solving the problem, Daphne giraldii Nitsche gel ointment of the present invention, is characterized in that: this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 5 ~ 10, adhesive agent 1 ~ 5, filler 0.1 ~ 0.5, Percutaneous absorption enhancer 0.1 ~ 0.5, wetting agent 5 ~ 15, cross-linking agent 0.1 ~ 0.5, cross-linking regulator 0.1 ~ 0.5, thickening agent 0.1 ~ 0.5, distilled water 15 ~ 20.
Described Chinese medicine extract refer in the mixture of Daphne giraldii Nitsche extract, the compound extract of Daphne giraldii Nitsche and Radix Lamiophlomidis Rotatae, Daphne giraldii Nitsche total coumarin, Daphne giraldii Nitsche total coumarin and Radix Lamiophlomidis Rotatae total iridoid glycosides any one.
Described adhesive agent refers in gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, part and polyacrylic acid NP-700, any one in part and in polyacrylic acid NP-600.
Described filler refer in Kaolin, zinc oxide, calcium carbonate any one.
Described Percutaneous absorption enhancer refers to any one of azone, oleic acid, Borneolum Syntheticum.
Described wetting agent refer in PEG400, glycerol, propylene glycol any one.
Described cross-linking agent refer in aluminum sulfate, aluminium sesquioxide, dihydroxyaluminum aminoacetate any one.
Described cross-linking regulator refers to tartaric acid or citric acid.
Described thickening agent refers to carbomer series.
The preparation method of Daphne giraldii Nitsche gel ointment as above, comprises the following steps:
(1) measure each component by formula;
(2) first Chinese medicine extract and adhesive agent are scattered in wetting agent, then add filler and Percutaneous absorption enhancer, stir, obtain A phase;
(3) thickening agent is dissolved in the distilled water of 3/4, makes it fully swelling in 30 ~ 50 DEG C of water-baths, obtain B phase;
(4) cross-linking agent and cross-linking regulator are dissolved in the distilled water of described 1/4 of remainder, obtain C phase;
(5) under stirring condition, by the A phase of the described step (4) C phase of gained and described step (2) gained 30 ~ 50 DEG C of mixing, then at 80 ~ 120rmin
-1add the B phase of described step (3) gained under rotating speed, stir into sticky shape semisolid fluid;
(6) described sticky shape semisolid fluid is coated on non-woven fabrics immediately, cover adherent layer, by specification cutting, obtain Daphne giraldii Nitsche gel ointment.
The present invention compared with prior art has the following advantages:
1, the present invention take Daphne giraldii Nitsche as principal agent, adopt modern extraction and separation technology, reference for modern Transdermal absorption new technique, application high molecular weight hydrophilic substrate, be developed to novel plaster---Daphne giraldii Nitsche gel ointment, there is antiinflammatory, analgesic activity, may be used for the treatment of swelling and ache that rheumatism, rheumatoid disease and a variety of causes cause.
2, instant invention overcomes traditional plaster heavy metals exceeding standard, Plumbum preparatium itself is poisonous, high temperature process destroys effective ingredient, and breathability, to the tackness of skin and the defect of moisture retention difference, make its use comfortable, reduce skin irritation, can repeatedly take off pull and without pain, not pollution clothes, skin noresidue, be easy to carry, and easily realize industrial automation production, be conducive to industrial upgrading.
3, the present invention adopts external application, often opens net weight 2.5 ~ 15 grams, directly sticks in affected part.
4, the analgesia of side's medicine of the present invention, antiinflammatory action:
4.1 hot plates cause mice pain experiment:
Healthy for female indicated weight Kunming mouse (is provided by Gansu Chinese of Traditional Chinese Medicine's Experimental Animal Center, production licence number SCXK (sweet) 2011-0001, the quality certification number 0001099), be positioned over be preheated to (55 ± 0.5) DEG C hot plate on, timing is started, pain threshold based on the time of licking metapedes to mice for the first time from mice metapedes contact hot plate.Select the mice 60 of Basic Pain Threshold at 5 ~ 30s only for experiment.Measure 2 times by upper method, interval 30min, average as pain threshold before administration.By pain threshold layering before administration, mice is divided into 6 groups at random: Matrix controls group, diclofenac group, Zushima gaoyao group, high, medium and low 3 the dosage groups of side's medicine of the present invention, often organizes 10.Before experiment, mouse back loses hair or feathers by 24h 8% sodium sulfide, and depilation area is about 4cm
2.Give test medicine and control drug respectively at depilation position, Matrix controls group area of applying ointment or plaster is 1.5cm
2, diclofenac group administration 0.2g/ time, Zushima gaoyao group area of applying ointment or plaster is 1.5cm
2, Daphne giraldii Nitsche gel ointment is little, in, large 3 dosage component area of not applying ointment or plaster is 1cm
2, 1.5cm
2, 2cm
2, the tablet of the corresponding size of clip is applied to back part of animal depilation district and carries out administration, and then is fixed by medicine with adhesive plaster, keeps medicine directly to contact 6h with animal skin, 1 times/day, for three days on end.60min, 90min, 120min pain threshold is measured by front method after last administration.Compare the change of pain threshold before and after administration, and (1) calculate threshold of pain raising percentage rate by formula.The results are shown in Table 1.
Threshold of pain increase rate (%)=
× 100% (1)
Table 1 Daphne giraldii Nitsche gel ointment of the present invention on the impact of hot plate method in mice induced pain (n=10,
± s)
Note: compare with Matrix controls group,
* p<0.05,
* p<0.01; Compare with Zushima gaoyao group,
△ p<0.05.
From table 1, compare with Matrix controls group, the basic, normal, high dosage of Daphne giraldii Nitsche gel ointment can improve different time sections pain threshold (P < 0.05 or 0.01) after administration; Compare with Zushima gaoyao group, the threshold of pain increase rate of the middle and high dosage of Daphne giraldii Nitsche gel ointment is all higher than Zushima gaoyao, and part-time section has obvious difference (P < 0.05); Daphne giraldii Nitsche gel ointment threshold of pain increase rate compares with diclofenac group, difference not obvious (P>0.05), not statistically significant.
4.2 acetic acid cause mouse writhing experiment:
Choose the healthy Kunming mouse 60 of indicated weight (provided by Gansu Chinese of Traditional Chinese Medicine's Experimental Animal Center, production licence number SCXK (sweet) 2011-0001, the quality certification number 0001099), male and female half and half.Grouping and medication the same.L h after last administration, the equal lumbar injection 0.6% acetum 0.1ml/10g of each group, and observed and recorded mouse writhing reacts writhing response number of times in time of occurrence and 15min immediately, then observes the pain reaction of every mice.With hindlimb extension, the distortion of abdominal part pasting board and abdominal muscle interval are punctured into index, writhing time of occurrence (incubation period) and writhing number of times in observed and recorded 15min.The results are shown in Table 2.
Table 2 Daphne giraldii Nitsche gel ointment of the present invention Dichlorodiphenyl Acetate cause mouse writhing reaction impact (
± s)
Note: compare with Matrix controls group,
* p<0.05,
* p<0.01; Compare with Zushima gaoyao group,
△ p<0.05.
Compare with Matrix controls group, pain incubation period after basic, normal, high 3 dosage of Daphne giraldii Nitsche gel ointment all can extend administration also reduces writhing response number of times (P < 0.05 or 0.01); Compare with Zushima gaoyao group, Daphne giraldii Nitsche gel ointment high dose group writhing response number of times is less than Zushima gaoyao group (P < 0.05); Although the comparatively diclofenac group pain prolongation of latency of the middle and high dosage group of Daphne giraldii Nitsche gel ointment, high dose group writhing number of times is less, difference not obvious (P>0.05), not statistically significant.
4.3 mice caused by dimethylbenzene xylene ear swelling tests:
Choose healthy Kunming mouse 60 (provided by Gansu Chinese of Traditional Chinese Medicine's Experimental Animal Center, production licence number SCXK (sweet) 2011-0001, the quality certification number 0001099), male and female half and half.Grouping and medication the same.After last administration 2 h, the auris dextra exterior feature of each experimental group every mice is coated with dimethylbenzene (0.04m/ only) and causes auricle edema, and left auricle is coated with normal saline and compares.After 60min, de-cervical vertebra puts to death mice, is cut by ears, use scales/electronic balance weighing with the card punch of diameter 8mm with position homalographic.Of poor quality for swelling with left and right two ear, (2) calculate inhibitory rate of intumesce by formula.The results are shown in Table 3.
Inhibitory rate of intumesce=
× 100% (2)
Table 3 Daphne giraldii Nitsche gel ointment xylol cause mice auricle swelling impact (n=10,
± s)
Note: compare with Matrix controls group,
* p<0.05,
* p<0.01; Compare with Zushima gaoyao group,
△ p<0.05.
As shown in Table 3, compare with Matrix controls group, the basic, normal, high dosage group of Daphne giraldii Nitsche gel ointment all can suppress auricle edema caused by dimethylbenzene, inhibitory rate of intumesce is respectively 26.34%, 38.21% and 44.89%, in certain dose-effect relationship, wherein middle and high dosage can obviously alleviate mice auricle swelling degree (
p< 0.05 or 0.01); In Daphne giraldii Nitsche gel ointment the inhibitory rate of intumesce of dosage and Zushima gaoyao without significant difference (
p>0.05), Daphne giraldii Nitsche gel ointment high dose inhibitory rate of intumesce higher than Zushima gaoyao (
p< 0.05); The inhibitory rate of intumesce of Daphne giraldii Nitsche gel ointment high dose higher than diclofenac group, but difference without significantly (
p>0.05).
To sum up result shows, Daphne giraldii Nitsche gel ointment of the present invention has good analgesia, antiinflammatory action, and successful is better than Zushima gaoyao.
Detailed description of the invention
embodiment 1daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 7.0kg, adhesive agent 2.0kg, filler 0.5kg, Percutaneous absorption enhancer 0.28kg, wetting agent 10.0kg, cross-linking agent 0.1kg, cross-linking regulator 0.1kg, thickening agent 0.3kg, distilled water 20 kg.
Wherein:
Chinese medicine extract refers to Daphne giraldii Nitsche extract and Daphne giraldii Nitsche extract powder.Adhesive agent refers to gelatin.Filler refers to Kaolin.Percutaneous absorption enhancer refers to azone.Wetting agent refers to PEG400.Cross-linking agent refers to aluminum sulfate.Cross-linking regulator refers to tartaric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment, comprises the following steps:
(1) measure each component by formula;
(2) adopt the RK-02 type cataplasma drug matrices horizontal mixer that Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd. produces, first Chinese medicine extract and adhesive agent are scattered in wetting agent, then add filler and Percutaneous absorption enhancer, stir, obtain A phase;
(3) thickening agent is dissolved in the distilled water of 3/4, makes it fully swelling in 30 ~ 50 DEG C of water-baths, obtain B phase;
(4) cross-linking agent and cross-linking regulator are dissolved in the distilled water of 1/4 of remainder, obtain C phase;
(5) adopt the RK-02 type cataplasma drug matrices horizontal mixer that Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd. produces, under stirring condition, by the A phase of the step (4) C phase of gained and step (2) gained 30 ~ 50 DEG C of mixing, then at 80 ~ 120rmin
-1add the B phase of step (3) gained under rotating speed, stir into sticky shape semisolid fluid;
(6) adopt the 400 type cataplasma coating machines that Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd. produces, sticky shape semisolid fluid is coated on non-woven fabrics immediately, cover adherent layer, the cataplasma die-cutting machine adopting Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd. to produce, by specification cutting, obtains Daphne giraldii Nitsche gel ointment.
embodiment 2daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 5.0kg, adhesive agent 1.0kg, filler 0.1 kg, Percutaneous absorption enhancer 0.1kg, wetting agent 5.0kg, cross-linking agent 0.2 kg, cross-linking regulator 0.2 kg, thickening agent 0.1kg, distilled water 15 kg.
Wherein:
Chinese medicine extract refers to the compound extract of Daphne giraldii Nitsche and Radix Lamiophlomidis Rotatae and the compound extract powder of Daphne giraldii Nitsche and Radix Lamiophlomidis Rotatae.
Adhesive agent refers to sodium carboxymethyl cellulose.Filler refers to zinc oxide.Percutaneous absorption enhancer refers to oleic acid.Wetting agent refers to glycerol.Cross-linking agent refers to aluminium sesquioxide.Cross-linking regulator refers to citric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment is same
embodiment 1.
embodiment 3daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 10.0kg, adhesive agent 5.0kg, filler 0.5kg, Percutaneous absorption enhancer 0.5kg, wetting agent 15.0kg, cross-linking agent 0.5kg, cross-linking regulator 0.5kg, thickening agent 0.5kg, distilled water 20kg.
Wherein:
Chinese medicine extract refers to Daphne giraldii Nitsche total coumarin and Daphne giraldii Nitsche total coumarin extract extract powder.
Adhesive agent refers to polyvinylpyrrolidone.Filler refers to calcium carbonate.Percutaneous absorption enhancer refers to Borneolum Syntheticum.Wetting agent refers to propylene glycol.Cross-linking agent refers to dihydroxyaluminum aminoacetate.Cross-linking regulator refers to tartaric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment is same
embodiment 1.
embodiment 4daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 6.0kg, adhesive agent 3.0kg, filler 0.2kg, Percutaneous absorption enhancer 0.3kg, wetting agent 7.0kg, cross-linking agent 0.3kg, cross-linking regulator 0.3kg, thickening agent 0.4kg, distilled water 16kg.
Wherein:
Chinese medicine extract refers to the mixture of Daphne giraldii Nitsche total coumarin and Radix Lamiophlomidis Rotatae total iridoid glycosides.
Adhesive agent refers to sodium polyacrylate.Filler refers to Kaolin.Percutaneous absorption enhancer refers to azone.Wetting agent refers to PEG400.Cross-linking agent refers to aluminum sulfate.Cross-linking regulator refers to citric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment is same
embodiment 1.
embodiment 5daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 8 .0kg, adhesive agent 4.0 kg, filler 0.3 kg, Percutaneous absorption enhancer 0.4 kg, wetting agent 12 kg, cross-linking agent 0.4 kg, cross-linking regulator 0.4 kg, thickening agent 0.2 kg, distilled water 18 kg.
Wherein:
Chinese medicine extract refers to Daphne giraldii Nitsche extract.
Adhesive agent refers in part and polyacrylic acid NP-700.Filler refers to zinc oxide.Percutaneous absorption enhancer refers to oleic acid.Wetting agent refers to glycerol.Cross-linking agent refers to aluminium sesquioxide.Cross-linking regulator refers to tartaric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment is same
embodiment 1.
embodiment 6daphne giraldii Nitsche gel ointment, this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 9 kg, adhesive agent 5 kg, filler 0.5 kg, Percutaneous absorption enhancer 0.3 kg, wetting agent 10 kg, cross-linking agent 0.2 kg, cross-linking regulator 0.2kg, thickening agent 0.5 kg, distilled water 20 kg.
Wherein:
Chinese medicine extract refers to the compound extract of Daphne giraldii Nitsche and Radix Lamiophlomidis Rotatae.
Adhesive agent refers in part and polyacrylic acid NP-600.Filler refers to calcium carbonate.Percutaneous absorption enhancer refers to Borneolum Syntheticum.Wetting agent refers to propylene glycol.Cross-linking agent refers to dihydroxyaluminum aminoacetate.Cross-linking regulator refers to citric acid.Thickening agent refers to carbomer series.
The preparation method of this Daphne giraldii Nitsche gel ointment is same
embodiment 1.
Claims (10)
1. Daphne giraldii Nitsche gel ointment, is characterized in that: this unguentum is made up of following parts by weight of raw materials: Chinese medicine extract 5 ~ 10, adhesive agent 1 ~ 5, filler 0.1 ~ 0.5, Percutaneous absorption enhancer 0.1 ~ 0.5, wetting agent 5 ~ 15, cross-linking agent 0.1 ~ 0.5, cross-linking regulator 0.1 ~ 0.5, thickening agent 0.1 ~ 0.5, distilled water 15 ~ 20.
2. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described Chinese medicine extract refer in the mixture of Daphne giraldii Nitsche extract, the compound extract of Daphne giraldii Nitsche and Radix Lamiophlomidis Rotatae, Daphne giraldii Nitsche total coumarin, Daphne giraldii Nitsche total coumarin and Radix Lamiophlomidis Rotatae total iridoid glycosides any one.
3. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described adhesive agent refers in gelatin, sodium carboxymethyl cellulose, polyvinylpyrrolidone, sodium polyacrylate, part and polyacrylic acid NP-700, any one in part and in polyacrylic acid NP-600.
4. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described filler refer in Kaolin, zinc oxide, calcium carbonate any one.
5. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described Percutaneous absorption enhancer refers to any one of azone, oleic acid, Borneolum Syntheticum.
6. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described wetting agent refer in PEG400, glycerol, propylene glycol any one.
7. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described cross-linking agent refer in aluminum sulfate, aluminium sesquioxide, dihydroxyaluminum aminoacetate any one.
8. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described cross-linking regulator refers to tartaric acid or citric acid.
9. Daphne giraldii Nitsche gel ointment as claimed in claim 1, is characterized in that: described thickening agent refers to carbomer series.
10. the preparation method of Daphne giraldii Nitsche gel ointment as claimed in claim 1, comprises the following steps:
(1) measure each component by formula;
(2) first Chinese medicine extract and adhesive agent are scattered in wetting agent, then add filler and Percutaneous absorption enhancer, stir, obtain A phase;
(3) thickening agent is dissolved in the distilled water of 3/4, makes it fully swelling in 30 ~ 50 DEG C of water-baths, obtain B phase;
(4) cross-linking agent and cross-linking regulator are dissolved in the distilled water of described 1/4 of remainder, obtain C phase;
(5) under stirring condition, by the A phase of the described step (4) C phase of gained and described step (2) gained 30 ~ 50 DEG C of mixing, then at 80 ~ 120rmin
-1add the B phase of described step (3) gained under rotating speed, stir into sticky shape semisolid fluid;
(6) described sticky shape semisolid fluid is coated on non-woven fabrics immediately, cover adherent layer, by specification cutting, obtain Daphne giraldii Nitsche gel ointment.
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| CN108771719A (en) * | 2018-08-08 | 2018-11-09 | 广州市力鑫药业有限公司 | A kind of gelling agent and preparation method thereof containing Daphne giraldii Nitsche extract |
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| CN112957346A (en) * | 2021-02-01 | 2021-06-15 | 北京化工大学 | Gentiana macrophylla cataplasm and preparation method thereof |
| CN112961204A (en) * | 2021-02-01 | 2021-06-15 | 北京化工大学 | Gentiopicroside cataplasm and preparation method thereof |
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| CN112961204A (en) * | 2021-02-01 | 2021-06-15 | 北京化工大学 | Gentiopicroside cataplasm and preparation method thereof |
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