CN1827150A - Externally applied emulsion film for treating rheumatic and rheumatoid disease and its preparing method - Google Patents
Externally applied emulsion film for treating rheumatic and rheumatoid disease and its preparing method Download PDFInfo
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Abstract
This invention is about an external use film for rheumatosis therapy and its preparing method, and it belongs to medicine field. Guiding by our country's medical theory, combine the traditional medicine with modern science and technology and daily-chemistry technique. It adopts the method of coupling film and Chinese traditional medicine tobacco extract, its full recipe and proportion are in specification. In this invention, the film self has no irritation to skin, it has appropriate viscosity, good film-forming property, and it is convenient to apply and is easy to peel. The Chinese traditional medicine tobacco extract self can dehumidificate, activate blood circulation and remove silt, activate collaterals to relieve pain, reduce edema to disperse paralysis, promote blood circulation and promote absorption. The combined recipe achieves the effect of convenient dosage and rapid therapy, and solves the problems of taking oral drugs difficulty and having toxic side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate in particular to a kind of externally-applied milk membrane for the treatment of rheumatism and preparation method thereof.
Background technology
The rheumatism of indication of the present invention comprises rheumatic arthritis, rheumatoid arthritis, belongs to the category of Chinese medicine and pharmacy arthromyodynia.Primary disease can divide two classes, and a kind of is to attack the person of causing because of the wind and cold dampness, claims " cold numbness "; Another kind is because of affection by exopathogenic cold-wind, and damp and hot multiple abscess meridians, or wind-cold damp pathogen Yu Huare of a specified duration and the person of causing claim " pyretic arthralgia ".The traditional Chinese medical science thinks, numbness be because of the damp and hot heresy that is affected by the cold cause with limbs joint pain, miserable numbness emphatically and moving obstacle be the disease of cardinal symptom, have clinically gradual, or the characteristics of outbreak repeatedly.Its pathogenesis mainly be because of QI and blood numbness resistance obstructed, muscle arteries and veins joint lose in moisten support due to.
At present, though the medicine of treatment rheumatism, rheumatoid disease is of a great variety, and curative effect differs, and particularly oral drugs are very poor because of its mouthfeel when taking, and have certain toxic and side effects, bring great misery for the patient in therapeutic process.So in the medicine of treatment rheumatism, rheumatoid disease, medicine for external use has accounted for very big ratio, but medicine for external use adopts traditional technology that boils mostly, makes the loss of effective components in the medicine serious, and various drug use inconvenience, and is unhygienic, also is unfavorable for preserving.
Summary of the invention
An object of the present invention is to provide a kind of externally-applied milk membrane for the treatment of rheumatism.
Another purpose of invention provides a kind of preparation method for the treatment of the externally-applied milk membrane of rheumatism.
For achieving the above object, a technical scheme of the present invention provides a kind of externally-applied milk membrane for the treatment of rheumatism, the externally-applied milk membrane of this treatment rheumatism is mainly by polyvinylpyrrolidone, polyvinyl alcohol, carboxymethyl cellulose, propylene glycol, glycerol, pure water, the Chinese medicine extract is formed, each material mass percentage composition is as follows: polyvinylpyrrolidone 2-6%, polyvinyl alcohol 3-8%, carboxymethyl cellulose 3-8%, propylene glycol 1-5%, glycerol 3-8%, pure water 8-15%, Chinese medicine extract 50-80%, can also contain methyl hydroxybenzoate 0-0.1%, spice 0-0.2%, ethanol 0-5%; Contain in the Chinese medicine extract: Daphne giraldii Nitsche 20-40 part, Caulis Erycibes 20-40 part, Cortex schizophragmatis integrifolii radicis 10-30 part, Herba Aristolochiae Mollissimae 10-30 part, Herba Aristolochiae 20-30 part, Radix Angelicae Pubescentis 10-20 part, Cortex Acanthopancis 10-20 part, Caulis Spatholobi 20-30 part, Semen Sinapis Albae 10-15 part, parthenocissus 10-30 part, Rhizoma Corydalis 20-30 part, Olibanum 10-30 part, Myrrha 10-30 part, Flos Carthami 10-30 part, rhizoma sparganic 10-20 part, Cortex Dictamni 10-15 part, Herba speranskiae tuberculatae 10-20 part, Radix Clematidis 20-30 part, Caulis Trachelospermi 10-30 part, Zaocys 10-20 part, vinegar 50-150 part, Chinese liquor 1000-2000 part.
The optimization formula that the present invention treats the externally-applied milk membrane of rheumatism is: each material percentage composition is as follows: polyvinylpyrrolidone 4%, polyvinyl alcohol 5%, carboxymethyl cellulose 5%, propylene glycol 3%, glycerol 5%, pure water 12%, Chinese medicine extract 65%.Contain in the Chinese medicine extract: 30 parts of Daphne giraldii Nitsche, 30 parts of Caulis Erycibess, 20 parts of Cortex schizophragmatis integrifolii radiciss, 20 parts of Herba Aristolochiae Mollissimaes, 25 parts of Herba Aristolochiaes, 15 parts of Radix Angelicae Pubescentiss, 15 parts of Cortex Acanthopanciss, 25 parts of Caulis Spatholobis, 12 parts of Semen Sinapis Albaes, 20 parts of parthenocissuss, 25 parts of Rhizoma Corydalis, 20 parts of Olibanums, 20 parts of Myrrhas, 20 parts on Flos Carthami, 15 parts of rhizoma sparganic, 12 parts of Cortex Dictamni, 15 parts of Herba speranskiae tuberculataes, 25 parts of Radix Clematidis, 20 parts of Caulis Trachelospermis, 15 parts of Zaocys, 100 parts of vinegars, 1500 parts of Chinese liquor.
The preparation method that the present invention treats the externally-applied milk membrane of rheumatism may further comprise the steps:
(1). the preparation of Chinese medicine extract;
(2). the preparation of film former;
(3). the preparation of newborn film.
Further specify the preparation method that the present invention treats the externally-applied milk membrane of rheumatism:
(1) preparation of Chinese medicine extract: raw material of Chinese medicine is placed in the clean container, adds 20-66 degree Chinese liquor, sealing was soaked after 30 days, filtered standby;
(2) preparation of film former: polyvinyl alcohol is put into water, is heated to 90 ℃, stir, complete molten back cooling adds polyvinylpyrrolidone and carboxymethyl cellulose after putting and being chilled to 20-40 ℃, stirs complete molten back and adds propylene glycol and glycerol, stirs molten be mixed standby after even; Methyl hydroxybenzoate and spice are made an addition in the dehydrated alcohol, stir complete molten back with above-mentioned poly-vinyl alcohol solution, mixing and stirring is standby;
(3) two solution that above-mentioned steps (1) and (2) are made mix, and promptly become isabelline dense emulsus dosage form, with bottle behind the prior art homogenizing or the flexible pipe of packing into the present invention treat the externally-applied milk membrane of rheumatism.
During use, only need this emulsifiable paste evenly put on the skin and be applied to affected part and get final product.Keep from newborn film edge it slowly to be taken off after about 30 minutes.Clean hygiene is pollution-free.
Beneficial effect of the present invention is: newborn film itself is non-stimulated to skin, and viscosity is suitable, and good film-forming property is put on the skin and is coated with convenience, peel off easily, the Chinese medicine extract itself has expelling wind and removing dampness, activating blood circulation to dissipate blood stasis, removing obstruction in the collateral to relieve pain, the diffusing numbness of detumescence, and blood circulation promoting is arranged, promote the effect of absorption.Two prescriptions are in conjunction with having reached convenient drug administration, and treatment has solved oral medication and taken difficulty rapidly, and the problem of toxic side effect.
Chinese herbal medicine among the present invention has 22 flavor Chinese herbal medicine to be formed, and the effect of each medicine of distinguishing the flavor of is as follows:
Daphne giraldii Nitsche: different name, Daphne giraldii Nitsche is the root bark or the peel of stem of thymelaeceae plant Daphne Giraldii Nitsche; Nature and flavor: arduous, temperature, slightly poisonous; Function cures mainly: expelling wind and removing dampness, warming spleen and stomach for dispelling cold.
Caulis Erycibes: different name, Bao Zheng rattan; Root, stem for the convolvulaceous plant Caulis Erycibes; Function cures mainly: relieving the exterior syndrome by diaphoresis, wind-damp dispelling, remove arthralgia pain, reducing swelling and alleviating pain.
Cortex schizophragmatis integrifolii radicis: different name: Folium paulowniae rattan; Nature and flavor: cool in nature, lightly seasoned; Function cures mainly: the dispelling the wind and dampness pathogens beriberi, extremities joint is ached.
Herba Aristolochiae Mollissimae: different name: clear GUFENG, cat ear; Nature and flavor: bitter, flat; Function cures mainly: rheumatic arthritis, stomachache, malaria, carbuncle.
Herba Aristolochiae: different name: herba aristolochiae, all drench rattan etc.; Nature and flavor: hardship, temperature; Function cures mainly: circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.
Radix Angelicae Pubescentis: be the root and rhizome of the heavy peristome Radix Angelicae Sinensis of samphire, Angelica pubescens, Xingan's Radix Angelicae Dahuricae, purple stem Radix Angelicae Pubescentis, Radix Heraclei hemsleyani, fur Radix Angelicae Pubescentis and Araliaceae Shi Yong Cortex araliae chinensis etc.Nature and flavor: arduous, temperature; Function cures mainly: dispel the wind, win and wet, cold expelling, pain relieving.
Cortex Acanthopancis: different name: CORTEX ACANTHOPANACIS; Nature and flavor: suffering, temperature; Function cures mainly: wind-damp dispelling, strengthening bone and muscle, blood circulation promoting and blood stasis dispelling.
Caulis Spatholobi: ratan such as leguminous plant spatholobus suberectus, Mucuna birdwoodiana, fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan or bright leaf Moghania fluminalis(C. B. Clarke) Li rattan; Nature and flavor: bitter sweet, temperature; Function cures mainly: invigorate blood circulation, Shujin; Control soreness of waist and knee joint, paralysis and numbness, menoxenia.
Semen Sinapis Albae: different name hot food is the seed of crucifer Caulis et Folium Sinapis albee; Nature and flavor: suffering, temperature; Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.
Parthenocissus: different name: Radix Parthenocissi Heterophyllae, different leaf Radix seu Caulis Parthenocissi tricuspidatae, lobule Caulis Sargentodoxae; Nature and flavor: hardship, temperature; Function cures mainly: expelling wind and removing dampness, collateral dredging, hemostasis, detoxifcation.
Rhizoma Corydalis: different name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis; Tuber for papaveraceae plant corydalis; Nature and flavor: arduous, temperature; Function cures mainly: invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, pain relieving.
Olibanum: be the gum resin of olive subject plant Boswellia carterii Birdw; Nature and flavor: arduous, temperature; Function cures mainly: regulating qi and activating blood, analgesic therapy chases after poison.
Myrrha: be the gum resin of olive subject plant myrrh or Alan's fort myrrh; Nature and flavor: hardship, flat; Function cures mainly: the blood and dissolving stasis that looses, subduing swelling and relieving pain.
Flos Carthami different name: red blue flower, thorn Flos Carthami; Nature and flavor: suffering, temperature; Function cures mainly: promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
Rhizoma sparganic different name: rhizoma scirpi; Tuber for Sparganiaceae plant rhizoma scirpi or little rhizoma scirpi, spire rhizoma scirpi; Nature and flavor: arduous, flat; Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.
Cortex Dictamni: different name north Cortex Dictamni is the root bark of rutaceae shaggy-fruited dittany; Nature and flavor: bitter salty, cold.Function cures mainly: dispel the wind dampness, heat-clearing and toxic substances removing.
Herba speranskiae tuberculatae: be the herb of euphorbia plant speranskia tuberculata or Balsaminaceae plant Impatientis; Nature and flavor: sweet in the mouth is nontoxic; Function cures mainly: dispel the wind, dehumidifying, Shujin, invigorate blood circulation, pain relieving.
Radix Clematidis: be the root of cohosh Radix Clematidis; Nature and flavor: hot salty, temperature, poisonous; Function cures mainly: wind-damp dispelling, the meridian dredging, expectorant, the mass in the abdomen of loosing.
Caulis Trachelospermi: different name: stone dace; Be the stem of apocynaceae plant trachelospermum jasminoide, leaf; Nature and flavor: hardship, cold; Function cures mainly: dispel the wind, collateral dredging, hemostasis, dissipating blood stasis.
Zaocys different name: the sword ridge crow tip, black Serpentis, blue or green Serpentis; Nature and flavor: sweet salty, flat; Function cures mainly: wind-damp dispelling, the meridian dredging.
Vinegar different name: Bitters; Be the liquid that contains acetic acid that leads to rice, wheat, Sorghum vulgare Pers. or wine, distiller grains etc.; Nature and flavor: bitter, temperature; Function cures mainly: dissipating blood stasis, hemostasis, detoxifcation, parasite killing.
Wherein: Daphne giraldii Nitsche, Caulis Erycibes, Cortex schizophragmatis integrifolii radicis, Herba Aristolochiae Mollissimae, Herba Aristolochiae, Caulis Spatholobi, parthenocissus etc. have expelling wind and dampness, channels sootheing and network vessel quickening, the effect of reducing swelling and alleviating pain; Flos Carthami, rhizoma sparganic, Olibanum, Myrrha etc. have blood circulation promoting and blood stasis dispelling, the repercussive effect of stimulating the menstrual flow, and Radix Clematidis, Zaocys, Caulis Trachelospermi etc. have the effect of dispelling wind and removing obstruction in the collateral, removing heat from blood detumescence; All medicines cooperate, and have possessed expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the pain relieving of energy network, the effect of detumescence eliminating impediment.
Routine patient is on probation surplus 100, this prescription to treat rheumatism, rheumatoid arthritis has significant curative effect.
| Pain relieving | Detumescence | Regulate | Consolidate | |
| Severe arthritis 10 people | 4-24 hour | Progressively subside a swelling 3-5 the course of treatment | 1-2 the course of treatment | 1-2 the course of treatment |
| Moderate arthritis 40 people | 2-24 hour | Progressively subside a swelling 2-3 the course of treatment | 1-2 the course of treatment | 1-2 the course of treatment |
| Mild osteoarthritis 30 people | 2-24 hour | 1 detumescence course of treatment | -- | 1-2 the course of treatment |
| Rheumatoid arthritis 20 people | 2-24 hour | 1-4 the detumescence course of treatment | 1-3 the course of treatment | 1-2 the course of treatment |
8-10 days per course of treatment
Experimental example 1: the Wang, in one's early years moist ill because of being subjected to, suffered from rheumatoid 30 years, weight when light during the state of an illness was once sought medical advice poor effect in inside and outside the province how tame hospital.
Symptom: duplex can not stretch two wrist moderates tetanic (the light activity degree is arranged), both shoulders pain, both arms can not go up act, two hip, two swelling and pain in knee, can not squat down, two ankle swells and ache, can only move and walk.
Chemical examination: rheumatoid factor is positive, and RF (+) ESR:85mm/h resists " 0 ":＜480u
Effect: 10 hours aftersensation pain reliefs of medication, alleviating pain and detumescence gradually after trial edition invention medicine external application 4 courses of treatment, symptom obviously alleviates; can be suitably movable, use medicine of the present invention to regulate 1 course of treatment again after, transference cure; can normal activity, consolidate 2 courses of treatment, do not see recurrence so far.
The specific embodiment:
Enumerate embodiment below, the present invention is further specified, but the present invention is not only limited to these embodiment.
Embodiment 1
The preparation of Chinese medicine extract: accurately take by weighing Daphne giraldii Nitsche 30 grams, Caulis Erycibes 30 grams, Cortex schizophragmatis integrifolii radicis 20 grams by prescription, Herba Aristolochiae Mollissimae 20 grams, Herba Aristolochiae 25 grams, Radix Angelicae Pubescentis 15 grams, Cortex Acanthopancis 15 grams, Caulis Spatholobi 25 grams, Semen Sinapis Albae 12 grams, parthenocissus 20 grams, Rhizoma Corydalis 25 grams, Olibanum 20 grams, Myrrha 20 grams, Flos Carthami 20 grams, rhizoma sparganic 15 grams, Cortex Dictamni 12 grams, Herba speranskiae tuberculatae 15 grams, Radix Clematidis 25 grams, Caulis Trachelospermi 20 grams, Zaocys 15 grams, vinegar 100 grams, 50 degree Chinese liquor, 1500 grams, raw material of Chinese medicine is placed in the clean container, add Chinese liquor, sealing was soaked after 30 days, filtered standby.
Embodiment 2
The preparation of film former: 115 gram polyvinyl alcohol are put into water, heat 90 ℃, be stirred to complete molten back cooling and put and add 92 gram polyvinylpyrrolidones and 115 gram carboxymethyl celluloses after being chilled to 40 ℃, stir complete molten back and add 70 gram propylene glycol and 115 gram glycerol, agitating solution is to evenly the back is standby;
0.1g methyl hydroxybenzoate and 0.1g fragrant citrus essence are made an addition in the 5g ethanol, stir complete molten back standby with above-mentioned solution mixing and stirring;
Will be in the above-mentioned film former add 1500 gram Chinese medicine extracts, mix, promptly become isabelline dense emulsus dosage form, with bottle behind the prior art homogenizing or the flexible pipe of packing into the present invention treat the externally-applied milk membrane of rheumatism.
Embodiment 3-7
With with the externally-applied milk membrane of the same method preparation treatment rheumatism of embodiment 1 in the preparation of Chinese medicine extract, concrete material name and proportioning that embodiment 3-7 uses are as shown in table 1.
| Material name | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | |
| Chinese medicine extraction liquid | Daphne giraldii Nitsche | 20 | 40 | 25 | 35 | 32 |
| Caulis Erycibes | 20 | 40 | 25 | 35 | 32 | |
| Cortex schizophragmatis integrifolii radicis | 10 | 30 | 15 | 20 | 25 | |
| Herba Aristolochiae Mollissimae | 10 | 30 | 15 | 20 | 25 | |
| Herba Aristolochiae | 20 | 30 | 22 | 28 | 25 | |
| Radix Angelicae Pubescentis | 10 | 20 | 12 | 15 | 18 | |
| Cortex Acanthopancis | 10 | 20 | 12 | 15 | 18 | |
| Caulis Spatholobi | 20 | 30 | 22 | 28 | 25 | |
| Semen Sinapis Albae | 10 | 15 | 11 | 13 | 14 | |
| Parthenocissus | 10 | 30 | 15 | 20 | 25 | |
| Rhizoma Corydalis | 20 | 30 | 22 | 28 | 25 | |
| Olibanum | 10 | 30 | 15 | 20 | 25 | |
| Myrrha | 10 | 30 | 15 | 20 | 25 | |
| Flos Carthami | 10 | 30 | 15 | 20 | 25 | |
| Rhizoma sparganic | 10 | 20 | 12 | 15 | 18 | |
| Cortex Dictamni | 10 | 15 | 11 | 13 | 14 | |
| Herba speranskiae tuberculatae | 10 | 20 | 12 | 15 | 18 | |
| Radix Clematidis | 20 | 30 | 22 | 28 | 25 | |
| Caulis Trachelospermi | 10 | 30 | 15 | 25 | 20 | |
| Zaocys | 10 | 20 | 12 | 15 | 18 | |
| Vinegar | 50 | 150 | 100 | 120 | 140 | |
| Chinese liquor | 1000 | 2000 | 1200 | 1700 | 1500 | |
Embodiment 8-12
With preparing the externally-applied milk membrane for the treatment of rheumatism with embodiment 2 same methods, concrete material name and proportioning that embodiment 8-12 uses are as shown in table 2.
Table 2: the concrete material name of externally-applied milk membrane and proportioning (unit: kg)
| Material name | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 | Embodiment 12 | |
| Film former | Polyvinylpyrrolidone | 2 | 6 | 3 | 4 | 5 |
| Polyvinyl alcohol | 3 | 8 | 4 | 6 | 7 | |
| Carboxymethyl cellulose | 3 | 8 | 4 | 6 | 7 | |
| Propylene glycol | 1 | 5 | 2 | 3 | 4 | |
| Glycerol | 3 | 8 | 4 | 6 | 7 | |
| Pure water | 8 | 15 | 11 | 13 | 14 | |
| Methyl hydroxybenzoate | 0 | 0.02 | 0.05 | 0.08 | 0.1 | |
| Herba Menthae essence | 0 | 0.05 | 0.1 | 0.15 | 0.2 | |
| Ethanol | 0 | 1.93 | 2.85 | 3.77 | 5 | |
| The Chinese medicine extract | 80 | 50 | 69 | 56 | 50.7 | |
Claims (7)
1. externally-applied milk membrane for the treatment of rheumatism, the externally-applied milk membrane of this treatment rheumatism mainly is made up of polyvinylpyrrolidone, polyvinyl alcohol, carboxymethyl cellulose, propylene glycol, glycerol, pure water, Chinese medicine extract, and each material mass percentage composition is as follows: polyvinylpyrrolidone 2-6%, polyvinyl alcohol 3-8%, carboxymethyl cellulose 3-8%, propylene glycol 1-5%, glycerol 3-8%, pure water 8-15%, Chinese medicine extract 50-80%.
2. the externally-applied milk membrane of treatment rheumatism according to claim 1 is characterized in that, the externally-applied milk membrane of this treatment rheumatism can also contain methyl hydroxybenzoate 0-0.1%, spice 0-0.2%, ethanol 0-5%.
3. the externally-applied milk membrane of treatment rheumatism according to claim 1 and 2, it is characterized in that each material mass percentage composition is as follows: polyvinylpyrrolidone 4%, polyvinyl alcohol 5%, carboxymethyl cellulose 5%, propylene glycol 3%, glycerol 5%, pure water 12%, Chinese medicine extract 65%.
4. the externally-applied milk membrane of treatment rheumatism according to claim 1 and 2 is characterized in that, each material mass part is as follows in the Chinese medicine extract: Daphne giraldii Nitsche 20-40 part, Caulis Erycibes 20-40 part, Cortex schizophragmatis integrifolii radicis 10-30 part, Herba Aristolochiae Mollissimae 10-30 part, Herba Aristolochiae 20-30 part, Radix Angelicae Pubescentis 10-20 part, Cortex Acanthopancis 10-20 part, Caulis Spatholobi 20-30 part, Semen Sinapis Albae 10-15 part, parthenocissus 10-30 part, Rhizoma Corydalis 20-30 part, Olibanum 10-30 part, Myrrha 10-30 part, Flos Carthami 10-30 part, rhizoma sparganic 10-20 part, Cortex Dictamni 10-15 part, Herba speranskiae tuberculatae 10-20 part, Radix Clematidis 20-30 part, Caulis Trachelospermi 10-30 part, Zaocys 10-20 part, vinegar 50-150 part, Chinese liquor 1000-2000 part.
5. the externally-applied milk membrane of treatment rheumatism according to claim 4 is characterized in that, each material mass part is as follows in the Chinese medicine extract: 30 parts of Daphne giraldii Nitsche, 30 parts of Caulis Erycibess, 20 parts of Cortex schizophragmatis integrifolii radiciss, 20 parts of Herba Aristolochiae Mollissimaes, 25 parts of Herba Aristolochiaes, 15 parts of Radix Angelicae Pubescentiss, 15 parts of Cortex Acanthopanciss, 25 parts of Caulis Spatholobis, 12 parts of Semen Sinapis Albaes, 20 parts of parthenocissuss, 25 parts of Rhizoma Corydalis, 20 parts of Olibanums, 20 parts of Myrrhas, 20 parts on Flos Carthami, 15 parts of rhizoma sparganic, 12 parts of Cortex Dictamni, 15 parts of Herba speranskiae tuberculataes, 25 parts of Radix Clematidis, 20 parts of Caulis Trachelospermis, 15 parts of Zaocys, 100 parts of vinegars, 1500 parts of Chinese liquor
6. method for preparing the externally-applied milk membrane of claim 1 or 2 described treatment rheumatisms, this method may further comprise the steps:
(1) preparation of Chinese medicine extract;
(2) preparation of film former;
(3) preparation of newborn film.
7. the preparation method of the externally-applied milk membrane of treatment rheumatism according to claim 6 is characterized in that, the step of this method is as follows:
(1) preparation of Chinese medicine extract: raw material of Chinese medicine is placed in the clean container, adds Chinese liquor, sealing was soaked after 30 days, filtered standby;
(2) preparation of film former: polyvinyl alcohol is put into water, is heated to 90 ℃, stir, complete molten back cooling adds polyvinylpyrrolidone and carboxymethyl cellulose after putting and being chilled to 20-40 ℃, stirs complete molten back and adds propylene glycol and glycerol, stirs molten be mixed standby after even; Methyl hydroxybenzoate and spice are made an addition in the ethanol, stir complete molten back standby with above-mentioned solution mixing and stirring;
(3) preparation of newborn film: the solution that above-mentioned steps (1) and step (2) are made mixes, and promptly becomes isabelline dense emulsus dosage form, with being the externally-applied milk membrane that the present invention treats rheumatism behind the prior art homogenizing.
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| CNA2005100515494A CN1827150A (en) | 2005-03-04 | 2005-03-04 | Externally applied emulsion film for treating rheumatic and rheumatoid disease and its preparing method |
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| CNA2005100515494A CN1827150A (en) | 2005-03-04 | 2005-03-04 | Externally applied emulsion film for treating rheumatic and rheumatoid disease and its preparing method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093796A3 (en) * | 2006-02-14 | 2008-03-13 | Cotrex Llc | Tobacco extraction methods and formulations |
| CN101204545B (en) * | 2007-12-12 | 2010-12-15 | 王芳 | Medicine for shoulder periarthritis |
| CN104056347A (en) * | 2014-06-04 | 2014-09-24 | 赵冬艳 | Medical mask and application method thereof |
| CN112370505A (en) * | 2020-12-16 | 2021-02-19 | 贵州省雄卫苗药研发有限公司 | Traditional Chinese medicine formula of male Wei Miao medicine for treating rheumatoid bone diseases and preparation and application methods thereof |
| CN115089665A (en) * | 2022-06-30 | 2022-09-23 | 银滔 | Formula of externally-applied traditional Chinese medicine ointment film-forming agent |
-
2005
- 2005-03-04 CN CNA2005100515494A patent/CN1827150A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007093796A3 (en) * | 2006-02-14 | 2008-03-13 | Cotrex Llc | Tobacco extraction methods and formulations |
| CN101204545B (en) * | 2007-12-12 | 2010-12-15 | 王芳 | Medicine for shoulder periarthritis |
| CN104056347A (en) * | 2014-06-04 | 2014-09-24 | 赵冬艳 | Medical mask and application method thereof |
| CN112370505A (en) * | 2020-12-16 | 2021-02-19 | 贵州省雄卫苗药研发有限公司 | Traditional Chinese medicine formula of male Wei Miao medicine for treating rheumatoid bone diseases and preparation and application methods thereof |
| CN115089665A (en) * | 2022-06-30 | 2022-09-23 | 银滔 | Formula of externally-applied traditional Chinese medicine ointment film-forming agent |
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