Technology contents
The purpose of this invention is to provide a kind of not only pharmaceutically acceptable but also edible compound Chinese medicinal preparation.Said preparation can be used as the food of prevention coronary heart disease, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headache at ordinary times and takes, and also can have therapeutical effect to diseases such as coronary heart disease, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headaches.
In order to realize order of the present invention, compound Chinese medicinal preparation of the present invention adopts and comprises that with Tonnae Sinensis (tender leaf or fruit), Flos Carthami, Semen Persicae, Radix Notoginseng, Radix Salviae Miltiorrhizae, the Cortex Eucommiae etc. be the crude drug of key component, is used for diseases such as prevention or treatment coronary disease pain, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headache.Tonnae Sinensis is the perennial arbor of Meliaceae Melia, but also is a kind of a kind of especially good to eat delicious food of plant, especially Tonnae Sinensis tender leaf of very common edible medicine, the Tonnae Sinensis fruit in traditional medicine as medicinal.Traditional medicine think Folium toonae sinensis, Tonnae Sinensis fruit (son) function cure mainly dispel the wind, cold expelling, pain relieving, circulation of qi promoting, can be used for treating anemofrigid cold, the thoracic obstruction, uncomfortable in chest, dizziness headache etc.; Flos Carthami is a kind of Chinese medicine commonly used, has the effect of blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia; Semen Persicae has blood circulation promoting and blood stasis dispelling, moisturizes the effect of intestine moistening; Radix Notoginseng has the effect of hemostasis dissipating blood stasis, subduing swelling and relieving pain; Radix Salviae Miltiorrhizae has stasis-dispelling and pain-killing, promoting blood flow to regulate menstruation, the effect of the relieving restlessness of nourishing heart; The effect of Cortex Eucommiae invigorating the liver and kidney, bone and muscle strengthening, antiabortive, blood pressure lowering.Modern study shows volatile oil such as containing elemene in the Tonnae Sinensis (tender leaf or fruit) and abundant vitamin and mineral; Contain saffloside, carthamone and neocarthamin in the Flos Carthami; Contain amygdaloside, emulsin, allantoinase, Lactose enzyme, vitamin, fatty wet goods in the Semen Persicae; Contain multiple saponin in the Radix Notoginseng, main for agate fat methane series saponin, also contain styptic activity composition dencichine and a small amount of flavonoid glycoside etc.; Mainly contain Tanshinone I, Tanshinone I I, cryptotanshinone, carnosol, protocatechualdehyde, Radix Salviae Miltiorrhizae acid etc. in the Radix Salviae Miltiorrhizae; Contain aucubin, gutta-percha, pectin, chlorogenic acid, vitamin etc. in the Cortex Eucommiae.Dialectical opinion according to Chinese medical theory is controlled and reasonable compatibility, through clinic trial, the present invention is based on Tonnae Sinensis (tender leaf or fruit), and the compatibility other drug has good effect to preventing or treating diseases such as coronary heart disease, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headache.
In order to reach better prevention or therapeutic effect, compound Chinese medicinal preparation of the present invention can also contain accessory constituent, and described accessory constituent comprises and is selected from the following crude drug one or more: the Cordyceps of invigorating the lung and the kidney, the Radix Panacis Quinquefolii of boosting qi and nourishing yin clearing away heat and promoting production of body fluid, the Radix Ginseng of strongly invigorating primordial QI invigorating the spleen to benefit the lung, the Radix Pseudostellariae of replenishing QI to invigorate the spleen promoting the production of body fluid for nourishing the lung, the Radix Astragali of invigorating QI to consolidate the body surface resistance diuresis poison holding, the promoting blood flow to regulate menstruation analgesic Radix Angelicae Sinensis of enriching blood, the Rhizoma Gastrodiae of suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion, the Ramulus Cinnamomi of the supporing yang activating QI of warming the meridian and promoting blood circulation, expelling pathogenic factors from muscles for reducing heat yang invigorating antidiarrheal Radix Puerariae, the Fructus Lycii that nourishing the liver and kidney benefit Tianjin makes eye bright, the Fructus Schisandrae Chinensis of supplementing QI for promoting the production of body fluid kidney calming, the Ramulus Uncariae Cum Uncis of heat clearing away suppressing the hyperactive liver to relieve the wind syndrome arresting convulsion, the Bulbus Allii Macrostemonis of activating YANG and eliminating stagnation circulation of qi promoting intestinal stasis relieving, the Radix Rehmanniae of clearing away heat and promoting production of body fluid cooling blood for hemostasis, the Flos Chrysanthemi that the wind heat clearing away suppressing the hyperactive liver that looses makes eye bright, the Pericarpium Citri Reticulatae of regulating qi-flowing for strengthening spleen drying dampness to eliminate phlegm, the Rhizoma Chuanxiong of blood-activating and qi-promoting wind-expelling pain-stopping, the Scorpio of endogenous wind stopping spasmolytic removing obstruction in the collateral to relieve pain, the Hirudo of eliminating blood stasis and inducing menstruation, the Zaocys of dispelling wind and removing obstruction in the collateral relieving convulsion etc.
Tonnae Sinensis is a kind of good to eat delicious food commonly used, among the peoplely commonly uses.Flos Carthami, Semen Persicae, Radix Notoginseng, Radix Salviae Miltiorrhizae, the Cortex Eucommiae are the kinds in the medicine-food two-purpose catalogue of Ministry of Public Health promulgation.So the present invention can be used as the food of prevention coronary heart disease, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headache and takes for a long time.And according to Chinese medical theory and practical clinical, the present invention has therapeutical effect to diseases such as coronary heart disease, arrhythmia, arteriosclerosis, hyperlipidemia, hypercholesterolemia, vascular dizziness headaches.
The consumption of each component of compound Chinese medicinal preparation of the present invention (by weight percentage) scope is:
Tonnae Sinensis (tender leaf or fruit etc.) 10~80%, Flos Carthami 1~30%, Semen Persicae 1~30%, Radix Notoginseng 2~50%, Radix Salviae Miltiorrhizae 2~50%, the Cortex Eucommiae 1~20%.
Be preferably: Tonnae Sinensis (tender leaf or fruit etc.) 60%, Flos Carthami 5%, Semen Persicae 5%, Radix Notoginseng 10%, Radix Salviae Miltiorrhizae 10%, the Cortex Eucommiae 10%.
In the compound Chinese medicinal preparation of the present invention the consumption of each component (by weight percentage) scope can also for:
Tonnae Sinensis (tender leaf or fruit etc.) 10~70%, Flos Carthami 1~25%, Semen Persicae 1~25%, Radix Notoginseng 2~40%, Radix Salviae Miltiorrhizae 2~40%, the Cortex Eucommiae 1~20%, accessory constituent 5~30%.
Be preferably: Tonnae Sinensis (tender leaf or fruit etc.) 55%, Flos Carthami 5%, Semen Persicae 5%, Radix Notoginseng 8%, Radix Salviae Miltiorrhizae 8%, the Cortex Eucommiae 8%, accessory constituent 11%.
Combination drug of the present invention can adopt the Chinese medicine preparation conventional method to make various oral, injections, external preparation uses for different crowds.
The present invention is by the following example and the in addition clearer and more definite explanation of experiment.But, be interpreted as the restriction that the present invention is subjected to these examples never in any form.
The specific embodiment
Embodiment 1:
Tonnae Sinensis is the Meliaceae plant, and its tender leaf or Tonnae Sinensis fruit are after harvesting, and drying in the air about 1~4 hour at room temperature shady and cool place, gets dried feed 10%, pulverizes; Get Flos Carthami 30%, Semen Persicae 1%, Radix Notoginseng 50%, Radix Salviae Miltiorrhizae 2%, the Cortex Eucommiae 7% five kinds of Chinese medicine, pulverize; With above-mentioned medicated powder mix homogeneously, can be packaged into oral formulations commonly used such as capsule, teabag or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 2:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, and drying in the air about 1~4 hour at room temperature shady and cool place, gets dried feed 10%, smashes; Add 8~10 times of water, the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 1.35 that the water extract is concentrated into proportion.Flos Carthami 1%, Radix Notoginseng 8%, Semen Persicae 30%, Radix Salviae Miltiorrhizae 50%, the Cortex Eucommiae 1% five tastes are pulverized.With above-mentioned medicated powder and Tonnae Sinensis water extract mix homogeneously, granulation, drying, add Tonnae Sinensis volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 3:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, and drying in the air about 1~4 hour at room temperature shady and cool place, gets dried feed 80%, smashes; 1% Semen Persicae, 14% Cortex Eucommiae powder are broken into coarse powder; Above-mentioned three flavors add 8~10 times of water, and the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 1.35 that the water extract is concentrated into proportion.1% Flos Carthami, 2% Radix Notoginseng, 2% Radix Salviae Miltiorrhizae, three flavors are pulverized.With above-mentioned medicated powder and water extract mix homogeneously granulate, drying, add Tonnae Sinensis volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 4:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 50% smashes; 5% Semen Persicae, 20% Cortex Eucommiae powder are broken into coarse powder; Above-mentioned three flavors add 8~10 times of water, and the heating extraction secondary is collected behind volatile oil cold preservation or the enclose standby simultaneously; It is about 1.20 that the water extract is concentrated into proportion, adds ethanol and makes that to contain the alcohol amount be about 50%, precipitate 12~48 hours, filtration, and filtrate continuation is concentrated into 1.20~1.40, and is standby.5% Flos Carthami, 10% Radix Notoginseng, 10% Radix Salviae Miltiorrhizae, three flavors are pulverized, and with the ethanol extraction of 5~10 times of amounts 60~95% 2~10 hours, filtration is concentrated into 1.20~1.40, and was standby.After said extracted thing vacuum drying or the spray drying, add volatile oil or its clathrate, appropriate amount of auxiliary materials, granulate, behind the mix homogeneously, tablet made by tabletting, coating or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 5:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 60% smashes; Are ground into 5% Semen Persicae, 10% second month in a season coarse powder; Above-mentioned three flavors add 8~10 times of water, and the heating extraction secondary is collected behind volatile oil cold preservation or the enclose standby simultaneously; It is about 1.20 that the water extract is concentrated into proportion, adds ethanol and makes that to contain the alcohol amount be 50%, precipitate 12~48 hours, filters, and filtrate continuation is concentrated into 120~1.40, add 2 times of water again and leave standstill, and filtration, cryoconcentration, cold drying, standby.5% Flos Carthami, 10% Radix Notoginseng, 10% Radix Salviae Miltiorrhizae, three flavors are pulverized, and with the ethanol extraction of 5~10 times of amounts 60~95% 2~10 hours, filter, and are concentrated into 1.20~1.40, and add ethanol and leave standstill, filtration, cryoconcentration, cold drying is standby.Taking polyethylene glycol melts in right amount, above-mentioned volatile oil, extract is added in the Polyethylene Glycol that melts mix homogeneously, splash into again to coolant, make drop pill, also above-mentioned volatile oil, extract can be added an amount of microcrystalline Cellulose and analog, make pellet.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 6:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 60% smashes; 5% Semen Persicae, 10~Cortex Eucommiae powder are broken into coarse powder; Above-mentioned three flavors add 8~10 times of water, and the heating extraction secondary is collected volatile oil cold preservation (A) simultaneously; It is about 1.20 that the water extract is concentrated into proportion, adds ethanol and makes that to contain the alcohol amount be more than 50%, precipitate 12~48 hours, filters, and filtrate continuation is concentrated into 120~1.40, adds 2 times of water again and leaves standstill, filtration, cryopreservation standby (B).5% Flos Carthami, 10% Radix Notoginseng, 10% Radix Salviae Miltiorrhizae, three flavors, pulverize, with 5~10 times of amount ethanol extractions of 60~95% 2~10 hours, filter, be concentrated into 1.20~1.40, adding ethanol leaves standstill, filter cryoconcentration, cold drying, add injection Oleum Arachidis hypogaeae semen or the analog and 1 times of amount lecithin or analog of 5 times of amounts, grinding makes homogenize standby (C).Under low temperature state, continue to grind the C component, slowly add the A component simultaneously, the last B component that slowly adds continued to homogenize 1 hour, and injection is made in fill.Dosage is counted with raw medicinal herbs: once-a-day, and each 4.5~12 grams, but life-time service.
Embodiment 7:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 74% smashes, and Ramulus Cinnamomi 2% is cut little disconnected, adds 8~10 times of water, and the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 1.35 that the water extract is concentrated into proportion.Flos Carthami 2%, Radix Notoginseng 7%, Semen Persicae 2%, Radix Salviae Miltiorrhizae 7%, the Cortex Eucommiae 2%, Cordyceps 1%) Radix Panacis Quinquefolii 2%, Rhizoma Gastrodiae 1% 8 flavor, pulverize.With above-mentioned medicated powder and Tonnae Sinensis, Ramulus Cinnamomi extract mix homogeneously, granulation, drying, add volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 8:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 30% smashes, and Pericarpium Citri Reticulatae 5% shredding adds 8~10 times of water, and the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 1.35 that the water extract is concentrated into proportion.Flos Carthami 2%, Radix Notoginseng 7%, Semen Persicae 2%, Radix Salviae Miltiorrhizae 20%, the Cortex Eucommiae 12%, the Radix Astragali 5%, Radix Pseudostellariae 8%, Ramulus Uncariae Cum Uncis 5%, Radix Rehmanniae 4% 9 flavor, dry, pulverizing.With above-mentioned medicated powder and Tonnae Sinensis, Pericarpium Citri Reticulatae extract mix homogeneously, granulation, drying, add volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 9:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 55% smashes, and Ramulus Cinnamomi 1% is cut little disconnected, and Bulbus Allii Macrostemonis 1% smashes, and adds 8~10 times of water, and the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 1.35 that the water extract is concentrated into proportion.Flos Carthami 5%, Radix Notoginseng 8%, Semen Persicae 5%, Radix Salviae Miltiorrhizae 8%, the Cortex Eucommiae 8%, Radix Ginseng 1%, Radix Puerariae 3%, Flos Chrysanthemi 5% 8 flavor are pulverized.Above-mentioned medicated powder is mixed evenly with extracts such as Tonnae Sinensis, Ramulus Cinnamomi, granulation, drying, add volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams can be taken for a long time.
Embodiment 10:
Tonnae Sinensis (tender leaf or fruit) is after harvesting, dries in the air about 1~4 hour at room temperature shady and cool place, and dried feed 30% smashes, and Radix Angelicae Sinensis 5%, Rhizoma Chuanxiong 3% shave add 8~10 times of water, and the heating extraction secondary is collected volatile oil or simultaneously with standby behind the cyclodextrin inclusion compound; It is about 135 that the water extract is concentrated into proportion.Flos Carthami 6%, Radix Notoginseng 7%, Semen Persicae 2%, Radix Salviae Miltiorrhizae 16%, the Cortex Eucommiae 6%, Rhizoma Gastrodiae 6%, Fructus Lycii 8%, Fructus Schisandrae Chinensis 2%, Scorpio 2%, Hirudo 2%, Zaocys 5%0 are pulverized simply.Above-mentioned medicated powder is mixed evenly with extracts such as Tonnae Sinensis, Radix Angelicae Sinensis, granulation, drying, add volatile oil clathrate compound and proper auxiliary materials, mix homogeneously, tabletting, coating make tablet or capsule charge is made capsule or pouch-packaged is made oral formulations commonly used such as granule, medicinal tea or external application medicated bag etc.Oral dose is counted with raw medicinal herbs: three times on the one, each 1.5~3.0 grams, this embodiment are mainly used in hyperlipidemia, sclerosis of blood vessels is seen treatment of apoplexy sequela and prevention Secondary cases apoplexy.
Experimental example 1:
Xiao, the man 52 years old now, because of boiler room work is arranged for a long time, suffers from the arrhythmia coronary heart disease several years in the time of 43 years old.Capsule through taking embodiment 1 removed examination in hospital after three months, and arrhythmia coronary heart disease is cured.After adhere to taking, existing Xiao is in the best of spirit, and is glowing with health.
Experimental example 2:
Deng, the man, 61 years old now, several years ago suffer from sclerosis of blood vessels, higher, the hypertension of blood fat, through take the capsule of embodiment 2 throughout the year, every index has all been recovered normally, and the mental status is good.
Experimental example 3:
Liu, the man, 71 years old now, old patients with gastric disease, dizziness headache, half body symptom such as itch often appears in hypertension in recent years, cerebrovascular sclerosis, take the capsule two weeks of the embodiment of the invention 1 after, promptly have clear improvement, now just adhering to taking.