CN111568986B

CN111568986B - Chinese medicinal oral prescription for setting fracture, external ointment and preparation method thereof

Info

Publication number: CN111568986B
Application number: CN202010419516.5A
Authority: CN
Inventors: 葛亚金; 刘秀嶶; 葛立岩
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-18
Filing date: 2020-05-18
Publication date: 2021-12-14
Anticipated expiration: 2040-05-18
Also published as: CN111568986A

Abstract

The invention relates to a traditional Chinese medicine oral prescription for setting a fracture, an external ointment and a preparation method thereof, belonging to the technical field of traditional Chinese medicine compositions. In order to solve the problems of slow effect and unobvious effect of the existing medicines for treating fracture, the invention provides an oral prescription and an external ointment for setting fracture, which take elder as monarch medicines, take vinegar calcined native copper, vinegar dried, yam rhizome, rhizoma drynariae, cucumber seed, goat blood, radix achyranthis bidentatae, teasel root and ground beeltle as ministerial medicines, and take rhubarb, frankincense, myrrh, catechu, peach kernel, safflower, pseudo-ginseng, dragon's blood, calcium carbonate, dogwood, prepared rhizome of rehmannia and cibotium barometz as assistants and guides to form monarch and ministerial compatibility, and realize the fracture setting effect with quick effect and short course of treatment by synergistic action. The oral preparation and the external ointment prepared from the pure traditional Chinese medicines are orally taken and externally applied, the active ingredients are easy to release, the absorption is fast, the bioavailability is high, the total effective rate is high, no toxic or side effect is caused, the affected part can be relieved by swelling and pain within 12 hours, and serious bone injuries such as fracture and the like can be cured within 45-60 days.

Description

Chinese medicinal oral prescription for setting fracture, external ointment and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine oral prescription for setting bones, an external ointment and a preparation method thereof.

Background

Fracture is a common disease in bone surgery, is mainly a disease of partial or complete fracture of bone caused by trauma, and has the main clinical manifestations of localized pain and tenderness at the fracture part, local swelling and ecchymosis, partial or complete loss of limb function. Fracture healing is a complex process of regenerative repair of bone tissue, influenced and regulated by many factors, both systemic and local. Fracture, wound infection, slow recovery of soft tissue injury, local hematoma difficult to absorb, traumatic pain, dysfunction and the like are frequently generated in the middle and later period recovery process of the wound.

At present, the fracture part is generally healed by adopting operation treatment or plaster fixation after bone docking clinically and depending on the self-regeneration capability of a patient. The treatment method has the advantages of slow callus growth, long treatment period and high cost, and causes the patients to suffer great pain for a long time. Most of the existing medicines are adjuvant treatments, the administration effect is not obvious, the phenomena of delayed healing and nonunion exist generally, and a medicine for treating the fracture with good treatment effect and quick response is urgently needed clinically.

Disclosure of Invention

In order to solve the problems of slow effect and unobvious effect of the existing medicines for treating fracture, the invention provides a traditional Chinese medicine oral prescription, an external ointment for setting fracture and a preparation method thereof.

The technical scheme of the invention is as follows:

the traditional Chinese medicine oral prescription for setting bones comprises the following components in parts by weight: 1-3 parts of wine-roasted rhubarb, 1-3 parts of vinegar-roasted frankincense, 1-3 parts of vinegar-roasted myrrh, 1-3 parts of catechu, 2-5 parts of teasel root, 3-8 parts of salt-fried achyranthes bidentata, 2-5 parts of rhizoma drynariae, 2-5 parts of sand-fried cibotium villosum, 2-5 parts of ground beetle, 1-3 parts of fried peach kernel, 1-3 parts of safflower, 2-5 parts of yam rhizome purification powder, 3-8 parts of elderberry root bark, 2-5 parts of cucumber seed, 1-3 parts of pseudo-ginseng, 1-3 parts of dragon blood, 3-8 parts of chicken branch inner skin, 2-5 parts of vinegar-calcined native copper, 1-3 parts of vinegar-dried, 1-3 parts of calcium carbonate, 1-3 parts of dogwood, 1-3 parts of prepared rehmannia root and 1-3 parts of goat blood.

Further, the composition comprises the following components in parts by weight: 2 parts of wine-fried rhubarb, 2 parts of vinegar-fried frankincense, 2 parts of vinegar-fried myrrh, 2 parts of catechu, 3 parts of teasel root, 4 parts of salt-fried achyranthes root, 3 parts of drynaria rhizome, 3 parts of sand-fried cibotium barometz, 3 parts of ground beeltle, 2 parts of fried peach seed, 2 parts of safflower, 3 parts of yam purified powder, 4 parts of elderberry root bark, 3 parts of cucumber seed, 2 parts of pseudo-ginseng, 2 parts of dragon's blood, 4 parts of chicken strip inner skin, 3 parts of vinegar-calcined native copper, 2 parts of vinegar-dried, 2 parts of calcium carbonate, 2 parts of dogwood, 2 parts of prepared rehmannia root and 2 parts of goat blood.

Furthermore, the dosage form of the oral prescription is powder, tablets, granules, capsules, soft capsules, pills, dripping pills or oral liquid preparations.

The oral preparation provided by the invention is orally taken twice a day before breakfast and supper, the dosage form of each adult contains 10g of total oral prescription, the oral preparation is taken with yellow wine, the dosage of the minors is halved, and the oral preparation is forbidden for pregnant women.

The invention provides a preparation method of a traditional Chinese medicine oral prescription for setting bones, which comprises the following steps:

step one, preparing vinegar calcined pyrite and vinegar dried: burning Pyritum to red, soaking in edible mature vinegar, cooling to obtain vinegar calcined Pyritum, and drying precipitate generated in edible mature vinegar for vinegar calcined Pyritum to obtain vinegar dried product;

step two, respectively crushing the vinegar calcined native copper, the dragon's blood and the goat blood to 100-120 meshes;

step three, mixing wine-fried rhubarb, vinegar-fried frankincense, vinegar-fried myrrh, catechu, teasel root, salt-fried achyranthes root, drynaria rhizome, sand-fried cibotium barometz, ground beetle, fried peach seed, safflower, Ningpo yam rhizome purified powder, elderberry root bark, cucumber seed, pseudo-ginseng, chicken tree twig inner skin, vinegar dried, calcium carbonate, dogwood and prepared rehmannia root, and crushing to 100-120 meshes;

step four, uniformly mixing the crushed components obtained in the step two and the step three to obtain a traditional Chinese medicine oral prescription for setting bones, adding pharmaceutically acceptable auxiliary materials to prepare powder, tablets, granules, capsules, soft capsules, pills, dripping pills or oral liquid preparations.

The traditional Chinese medicine external ointment for setting bones comprises the following components in parts by weight: the traditional Chinese medicine oral prescription for setting bones provided by the invention comprises 1-3 parts of camphor, 0.2-0.5 part of elderberry root bark, 0.2-0.5 part of anisodus acutangulus, 0.4-0.8 part of anisodus acutangulus, 0.2-0.5 part of yellow lead, 0.2-0.5 part of fructus cannabis, 0.1-0.3 part of radix aconiti agrestis, 0.2-0.5 part of vinegar calcined pyrite, 0.1-0.3 part of dragon's blood, 1-3 parts of mature vinegar, 3-6 parts of minium and 10-12 parts of vegetable oil.

Further, the composition comprises the following components in parts by weight: the traditional Chinese medicine oral prescription for setting bones provided by the invention comprises 2 parts of camphor 0.3 part, elderberry root bark 0.3 part, anisodus acutangulus 0.6 part, yellow birthday pellet 0.3 part, fructus cannabis 0.3 part, radix aconiti 0.2 part, radix aconiti agrestis 0.2 part, vinegar calcined pyrite 0.3 part, dragon's blood 0.2 part, mature vinegar 2 parts, minium 4 part and vegetable oil 10 parts.

The invention provides a preparation method of a traditional Chinese medicine external ointment for setting a fracture, which comprises the following steps:

step a, soaking elderberry root bark, yellow-life lead, fructus cannabis, raw radix aconiti agrestis and half part of radix anisodii acutanguli in vegetable oil for at least 7 days;

b, pouring the oil and the medicine soaked in the step a into a copper pot, decocting for 10-15 minutes by using slow fire, keeping the oil temperature at 100 +/-5 ℃ to extract the active ingredients in the medicine components, then heating the oil to 160 +/-5 ℃ by using medium fire, decocting for 25-35 minutes until the medicine liquid is black and yellow, filtering and collecting the medicine oil;

step c, decocting the medicinal oil collected in the step b with medium fire to enable the oil temperature to rise to 260 +/-5 ℃, changing to big fire when the oil bloom rolls and rises light smoke, rapidly pouring the minium into the medicinal oil within 10 seconds under the stirring state, rapidly rising the oil temperature to 310 +/-5 ℃, decocting within 15-30 seconds until the oil bloom is severe, immediately taking the pot out of the fire, stopping heating, slowly pouring the plaster materials in the pot into cold water at the temperature of 4-10 ℃ for cooling, stirring while pouring, then changing the cold water every 10 minutes, and taking out the plaster materials after cooling for 6-24 hours;

and d, putting the plaster material obtained in the step c and mature vinegar into a pot, re-melting the plaster material by using a small fire, adding camphor, the Chinese medicinal oral preparation for setting the fracture as claimed in claim 1, vinegar calcined native copper, dragon's blood and the remaining half part of radix anisodii acutae, stirring uniformly, stopping heating, and cooling for later use.

When the plaster is used, the plaster is heated to melt, the plaster is coated on non-woven fabric according to the size of a focus to prepare the plaster, the weight of each plaster is 10-15 g, and the plaster is replaced every 2-3 days.

And d, further, the preparation method of the vinegar calcined pyrite in the step d comprises the steps of burning the pyrite till the pyrite is completely red, immersing the pyrite into edible mature vinegar, and cooling the vinegar calcined pyrite to obtain the vinegar calcined pyrite.

Further, the vinegar calcined native copper, the anisodus acutangulus and the dragon's blood are all powder ground to 100-120 meshes.

The invention has the beneficial effects that:

the traditional Chinese medicine oral prescription and the external ointment for setting the fracture provided by the invention realize the fracture setting effect with quick effect and short treatment course through the mutual compatibility and combined action of various raw material medicines. The whole formula of the invention has the effects of nourishing liver and kidney, strengthening tendons and bones, relaxing muscles and tendons, promoting blood circulation, dredging channels and collaterals, removing blood stasis, relieving swelling and pain, promoting the growth of muscles and bones, and repairing wound healing; can be used for treating fracture due to muscle and tendon injury, traumatic injury, soft tissue injury, old fracture, femoral head necrosis, hyperosteogeny, and osteoporosis. Meanwhile, the oral preparation and the external ointment have obvious anti-inflammatory and analgesic effects and are used for treating weak bones and muscles, traumatic arthritis, proliferative arthritis, rheumatoid bone diseases and various lumbocrural pains caused by bone fracture diseases.

The oral preparation and the external ointment prepared from the pure traditional Chinese medicines have the advantages of easy release of effective components, quick absorption, high bioavailability, mild drug property and no toxic or side effect proved by clinical application. The traditional Chinese medicine composition disclosed by the invention is taken orally and applied externally, can be used for treating both internal and external diseases, is quick in effect, short in treatment course and high in total effective rate, and can be used for quickly and effectively treating local swelling and pain in early stage of bone fracture within 12 hours; the soft tissue injury can be cured within 7-10 days, and the severe bone injuries such as fracture and the like can be cured within 45-60 days.

The invention has unique process and simple and convenient preparation, furthest reserves the medicinal components of the medicament, fully exerts the medicinal efficacy, reduces the production cost, lightens the economic burden of patients and has wide application prospect.

Drawings

Fig. 1 is an X-ray film after the femoral trochanter fracture healed 60 days after the oral formulation and the external ointment prepared in example 2 and example 6 were orally and externally applied to case 1;

fig. 2 is an X-ray film of a midstream humeral fracture caused by fall injury in case 2;

fig. 3 is an X-ray film of case 2 after 30 days of oral and external formulations and external ointments prepared in examples 2 and 6.

Detailed Description

The technical solutions of the present invention are further described below with reference to the following examples, but the present invention is not limited thereto, and any modifications or equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Example 1

The pharmacology of each medicinal material in the embodiment is as follows:

wine-fried rhubarb:

the radix et rhizoma Rhei is dry root and rhizome of medicinal radix et rhizoma Rhei of Polygonaceae, and the radix et rhizoma Rhei processed with wine is prepared by spraying radix et rhizoma Rhei slice with yellow wine, slightly stewing, parching with slow fire in a pot, taking out, and air drying. Bitter and sweet in taste, has the main function of purging heat and clearing heat from the intestine, cooling blood and removing toxicity, removing blood stasis and dredging channels, and wine-roasted rhubarb has the function of activating blood.

Vinegar-fried frankincense:

the Olibanum is gum resin of Boswellia carterii of Burseraceae. The vinegar processed Olibanum is prepared by parching clean Olibanum with slow fire until surface is melted, spraying rice vinegar, parching until outer layer is bright, taking out, and cooling. Pungent and bitter with warm property. The functions are mainly used for regulating qi and activating blood, relieving pain and dispelling toxin.

Processing myrrh with vinegar:

the Myrrha is gum resin of Commiphora myrrha or Commiphora myrrha of Burseraceae. The vinegar processed Olibanum is prepared by parching Myrrha with slow fire until the surface is melted, spraying rice vinegar, parching until the outer layer is bright, taking out, and cooling. Bitter, pungent and mild in flavor, and mainly used for dissipating blood stasis, relieving swelling and alleviating pain.

Catechu:

catechu is dried soft extract of peeled branch and dried stem of Catechu of Albizia of Leguminosae. Slightly cold in nature and bitter in taste, and mainly indicated for astringing dampness, promoting granulation and healing wound.

Teasel root:

radix Dipsaci is root of radix Dipsaci of Himalayanaceae family. Bitter and pungent in flavor, slightly warm in nature. The functions are mainly used for tonifying liver and kidney, strengthening bones and muscles, regulating blood vessels, continuing fracture and treating metrorrhagia and metrostaxis.

Parching Achyranthis radix with salt:

achyranthes bidentata is a herb plant used as a perennial herb in amaranthaceae. Bitter, sour and neutral, and has the functions of tonifying liver and kidney, strengthening bones and muscles, removing blood stasis, dredging channels and inducing blood to descend.

Rhizoma drynariae:

the rhizoma Drynariae is dried rhizome of Drynariae rhizoma of Polypodiaceae. Warm and bitter, and mainly used for tonifying kidney, strengthening bone, healing wound and relieving pain.

Parching rhizoma Cibotii with sand to remove rhizoma Cibotii:

rhizoma Cibotii is the rhizome of Cibotium barometz of the family Hyriopsis cumingii. Warm in nature, sweet and bitter in taste. The functions of the medicine are mainly used for stopping bleeding, tonifying liver and kidney, strengthening waist and spine and expelling wind-damp.

Ground beetle:

the Eupolyphaga Seu Steleophaga is female dry body of Eupolyphaga Seu Steleophaga or Eupolyphaga Seu Steleophaga of Cyperaceae. Salty and cold. The functions are mainly used for breaking blood stasis and reuniting bones and muscles.

Frying peach kernels:

peach kernel is the seed of peach, a rose leaf plant. Bitter, sweet and neutral. The functions are mainly used for activating blood and dissolving stasis, relaxing bowel, relieving cough and asthma.

Safflower:

carthami flos is tubular flower of Carthamus tinctorius L of Compositae. Warm in nature and pungent in flavor. The functions are mainly used for promoting blood circulation, dredging channels, removing blood stasis and relieving pain.

1, Ningpo Yam rhizome:

rhizoma Dioscoreae Nipponicae is rhizome of Dioscorea nipponica Makino of Dioscoreaceae, and is prepared by picking in spring and autumn, removing outer skin and fibrous root, slicing, and sun drying. Warm in nature, sweet and bitter in taste; the functions are mainly used for dredging channels and activating blood circulation, relieving cough and reducing sputum, and dispelling wind and relieving pain, and is used for treating waist and leg pain, numbness of bones and muscles and traumatic injury, and mainly contains various steroidal saponins such as dioscin and the like.

The preparation method of the yam purification powder used by the invention comprises the following steps: slicing rhizoma Dioscoreae Nipponicae, pulverizing, soaking in distilled water for 24 hr, grinding into fine powder with colloid mill, filtering with 200 mesh sieve, removing coarse residue, collecting filtered powder, dehydrating and drying to obtain rhizoma Dioscoreae Nipponicae purified powder. Compared with the raw materials, the steroidal compounds contained in the yam purified powder prepared by the invention are improved, and the yam purified powder is easier to be absorbed by human bodies, thereby improving the remarkable detumescence and pain-relieving curative effects of the yam purified powder in the aspects of treating various muscle and bone diseases such as rheumatism, rheumatoid diseases, various arthropathy, hyperosteogeny, large-bone-joint traumatic injury and the like.

Elderberry root bark:

elderberry is the shoot of the plant of Caprifoliaceae. Neutral in nature, sweet and bitter; the main functions are dispelling wind and promoting diuresis; promoting blood circulation; stopping bleeding. Chief wind-damp arthralgia; gout; Kaschin-Beck disease; acute and chronic nephritis; rubella; traumatic injury; swelling and pain of fracture; bleeding due to trauma. Sambucus nigra collected from northeast has the best curative effect, and contains various cold-resistant substances because it grows in the coldest and humid deep mountains and in shady and cool places with little sunlight. In the field, tender strips of elderberry are cut and collected in spring or autumn and dried for pharmacy, the outer skin of the root of the elderberry is selected as a medicine, and the bone-knitting curative effect is improved by 2-3 times compared with that of the tender strips.

Cucumber seeds:

cucumber seeds are seeds of cucumber belonging to the family Cucurbitaceae. The functions are mainly used for treating fracture, muscle injury, rheumatic arthralgia and senile cough and asthma.

Pseudo-ginseng:

notoginseng radix is root of Panax notoginseng (Burk.) F.H.Chen of Araliaceae. Warm, sweet and bitter. The functions are mainly used for dissipating blood stasis and stopping bleeding, and relieving swelling and pain.

Dragon's blood:

sanguis Draxonis is resin of fruit and stem of daemonorops draco of Palmaceae, or resin of dracaena cochinchinensis (lour.) nakai of Liliaceae or dracaena cambogia (lour.) nakai. Pungent and salty in flavor, and mainly used for promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, promoting granulation, and healing wound.

Chicken strip inner skin:

the JISHUZHI is Viburnum sargentii of Viburnum of Caprifoliaceae, and is usually used as medicine with tender branches, leaves and fruits in the field. Sweet, bitter and neutral, and can be used for treating rheumatic arthritis, soreness of waist, skelalgia, and traumatic injury. The invention collects old tree strips for years in spring and autumn or winter, removes outer old bark, takes inner tender bark as medicinal material, and the medicinal collagen fiber component for bone setting is mainly in the bark, which is the main material for growing tendons and bones, so the invention uses the tender bark in the middle layer of the chicken tree strips as the medicinal material, the bone setting effect is obviously better than that of the tender strips, and the bone setting effect of the formula is improved.

Calcining Pyritum with vinegar:

the native copper is pyrite which is a sulfide iron ore group mineral, and has the functions of reducing singency, smoothing, removing blood stasis, setting bone and stopping pain. The invention is quenched and forged by edible old vinegar, so that the chemical components in the vinegar can be absorbed by the human body more easily. The native copper contains a large amount of copper, zinc, iron, manganese, calcium and other elements. The mineral substances such as calcium are absorbed by human body and then deposited and mineralized in the callus to increase the calcium fusion amount, the zinc, iron and manganese are beneficial to collagen synthesis, the copper can improve the activity of lysine oxidase, the toughness of collagen fibers is enhanced, the insolubility of collagen is increased, the biomechanical strength is enhanced, and the strong stimulation can promote the generation of new bone, so the pyrite has the function of promoting the healing of fracture. Furthermore, native copper also promotes reticulocyte and hemochrome proliferation in the bone marrow itself and its surrounding blood.

Drying the vinegar: the vinegar dry used in the invention is powder obtained by drying precipitates in edible mature vinegar left after forging native copper for many times, and the invention creatively uses the vinegar dry as a medicine, not only fully utilizes mineral elements dissolved in the mature vinegar when forging native copper, but also can utilize the effects of activating blood circulation and dissipating blood stasis of acetic acid, and the acetic acid can decompose the blood stasis of wounds, so that the solidified blood stasis, tissue fluid and other substances are dissolved to achieve the purpose of smoothing qi and blood. Meanwhile, the acetic acid in the dried vinegar can inhibit the reproduction of bacteria, so that the effect of setting a broken bone is improved and the wound infection is prevented. In addition, the vinegar dried bean curd also contains rich amino acids, certain glycolysis enzymes and various unsaturated fatty acids, thereby providing rich nutrition for fracture healing.

The application combines the dried vinegar and the native copper, the dried vinegar is decomposed to soften hard mass, activate blood circulation to dissipate blood stasis to relieve pain, has the functions of relaxing muscles and tendons and strengthening bones, and the native copper is activated to dissipate blood stasis, detumescence to relieve pain, has the functions of growing muscles and bones, can promote the absorption of organisms on active ingredients of the native copper, strengthens the functions of activating blood circulation to dissipate blood stasis and realizes the effect of 1+1 > 2.

Dogwood fruit:

the Corni fructus is dry mature pulp of Corni fructus of Cornaceae, and is sour, astringent and slightly warm, and has the functions of tonifying liver and kidney, and arresting seminal emission.

Prepared rhizome of rehmannia:

the radix rehmanniae Preparata is prepared by processing and soaking radix rehmanniae Preparata of Scrophulariaceae. Sweet taste and warm nature, and mainly indicated for tonifying blood and nourishing, replenishing essence.

Goat blood:

the goat blood is dried blood of sheep of Bovidae. Sweet taste and strong heat, and has the functions of promoting blood circulation, removing blood stasis, relieving pain and setting bone.

The inventor modifies the ancestral original prescription through decades of clinical application experiences, combines theory and fact, is integrated with local parts, comprehensively utilizes different functions of various traditional Chinese medicines, aims at treating both symptoms and root causes, improving curative effect and avoiding toxic and side effects, reforms the original prescription, achieves short treatment course, simple and convenient administration, treats both symptoms and root causes, is integrated with local parts and comprehensively uses the medicines. The invention uses the same oral prescription and external application paste to promote blood circulation, remove meridian obstruction, remove blood stasis, relieve swelling and pain, and heal wound in the early, middle and later stages of fracture treatment, regulates qi, promotes blood circulation, removes blood stasis, promotes tissue regeneration, grows tendons and bones, enriches blood and benefits marrow all the time, so the newly developed bone-knitting medicine does not need to apply different prescriptions to treat fracture and soft tissue injury in stages. The long-term clinical application verification shows that the invention has the advantages of simple and convenient medication, low cost, high curative effect, relieving pain of patients in time, reducing economic burden and the like.

The treatment principle and the treatment method of the invention are explained by the formula of the traditional Chinese medicine oral prescription for setting bones:

the elderberry root bark and the chicken tree inner layer bark are monarch drugs and have the effects of growing muscle and bone, relieving pain and swelling and promoting bone growth when being matched with each other; the vinegar calcined native copper, the vinegar dried, the yam, the rhizoma drynariae, the radix achyranthis bidentatae, the cucumber seed, the goat blood, the teasel root and the ground beeltle are used as ministerial drugs and are matched with monarch drugs to further strengthen the effects of breaking blood stasis and reuniting bones and muscles; radix et rhizoma Rhei, Olibanum, Myrrha, Catechu, semen Persicae, Carthami flos, Notoginseng radix, sanguis Draxonis, calcium carbonate, Corni fructus, radix rehmanniae Preparata, and rhizoma Cibotii as adjuvant drugs, and has effects of promoting blood circulation for removing blood stasis, and relieving swelling and pain. Because the invention further optimizes the medicine-taking parts of the elderberry and the chicken tree twigs, the analgesic and detumescence effect of the monarch drug can quickly and effectively treat local swelling and pain in the early stage of bone injury after 12 hours of medicine application, and relieve the pain of patients; the stasis breaking function of the ministerial drugs can quickly discharge the blood stasis, the normal blood circulation can be quickly recovered under the action of the ventilation and blood circulation of the adjuvant drugs, the normal blood circulation of the affected part is ensured, sufficient nutrient substances are provided for injury repair, the rapid formation of poroma is promoted by the combined action of the monarch drugs and the ministerial drugs, the bone gap is filled, and the osteonosus is hardened to be bone; the monarch drug, the ministerial drug and the assistant drug are organically combined into a whole, and the effects of quick response and short treatment course can be realized under the synergistic action of the monarch drug, the ministerial drug and the assistant drug. The traditional Chinese medicine composition further improves the curative effect of the traditional Chinese medicine composition for setting the fracture through reasonable compatibility, and achieves the obvious effects that the soft tissue injury can be cured within 7-10 days, and the severe bone injury such as fracture can be cured within 45-60 days.

Example 2

The embodiment provides a traditional Chinese medicine oral prescription for setting bones, which comprises the following components in parts by weight: 100g of wine-fried rhubarb, 100g of vinegar-fried frankincense, 100g of vinegar-fried myrrh, 100g of catechu, 150g of teasel root, 200g of salt-fried achyranthes bidentata, 150g of drynaria rhizome, 150g of sand-fried cibotium barometz, 150g of ground beeltle, 100g of fried peach seed, 100g of safflower, 150g of yam purified powder, 200g of elderberry root bark, 150g of cucumber seed, 100g of pseudo-ginseng, 100g of dragon's blood, 200g of chicken tree twig inner skin, 150g of vinegar-calcined native copper, 100g of vinegar, 100g of calcium carbonate, 100g of dogwood, 100g of prepared rehmannia root and 100g of goat blood.

Example 3

The embodiment provides a traditional Chinese medicine oral prescription for setting bones, which comprises the following components in parts by weight:

150g of wine-fried rhubarb, 150g of vinegar-fried frankincense, 150g of vinegar-fried myrrh, 150g of catechu, 250g of teasel root, 400g of salt-fried achyranthes root, 250g of drynaria rhizome, 250g of sand-fried cibotium barometz, 250g of ground beeltle, 150g of fried peach seed, 150g of safflower, 250g of yam purified powder, 400g of elderberry root bark, 250g of cucumber seed, 150g of pseudo-ginseng, 150g of dragon's blood, 400g of chicken tree strip inner skin, 250g of vinegar-calcined native copper, 150g of vinegar-dried, 150g of calcium carbonate, 150g of dogwood, 150g of prepared rehmannia root and 150g of goat blood.

Example 4

A method for preparing the oral formulation of a Chinese medicine for bone-knitting provided in embodiment 2 or embodiment 3, comprising the steps of:

Each 10g of the powder is one packet, each particle of the zero-size hollow capsule comprises 0.5g, each pill of the honeyed pill comprises 10g, and each tablet comprises 0.5 g.

The application and dosage are as follows: the composition is orally taken once before breakfast and supper, and is administered with yellow wine, one package of powder is taken every time, 20 capsules are taken every time, one pill is taken every time, 20 tablets are taken every time, half of honeyed pills are taken every time, children or juveniles are forbidden to eat chicken and fish seafood during taking, and pregnant women are forbidden to take the composition.

Example 5

The embodiment provides a traditional Chinese medicine external ointment for setting a bone, which comprises the following components in parts by weight: the traditional Chinese medicine oral preparation for setting bones provided in example 1 comprises 1-3 parts of traditional Chinese medicine oral preparation, 0.2-0.5 part of camphor, 0.2-0.5 part of elderberry root bark, 0.4-0.8 part of anisodus acutangulus, 0.2-0.5 part of yellow lead, 0.2-0.5 part of fructus cannabis, 0.1-0.3 part of radix aconiti agrestis, 0.2-0.5 part of vinegar calcined pyrite, 0.1-0.3 part of dragon's blood, 1-3 parts of mature vinegar, 3-6 parts of minium and 10-12 parts of vegetable oil.

In the embodiment, compared with the embodiment 1, five medicinal materials are added, and the pharmacology is as follows:

three thirds:

radix Anisodi Acutanguli is root, leaf or seed of dicotyledonous plant Solanaceae. Warm, pungent and bitter, and mainly indicated for stomachache, fracture, rheumatalgia and traumatic injury.

Huangshou Dan:

huangshoudan, also known as forsythia, is a dried fruit of forsythia suspense, a plant of the genus forsythia of the family Oleaceae. Cool and bitter, and mainly used for clearing away heat and toxic material, dispersing swelling and dissipating nodulation, and dispelling wind-heat.

Fructus cannabis:

fructus cannabis is a dry mature seed of cannabis sativa of the family Moraceae, flat and sweet, and has the function of moistening the intestines and relaxing the bowels.

Raw radix aconiti:

radix Aconiti is the mother root of Aconitum carmichaeli Debx of Ranunculaceae, and has the functions of dispelling pathogenic wind, removing dampness, warming channels and relieving pain.

Raw kusnezoff monkshood root:

the radix Aconiti Kusnezoffii is root tuber of Aconitum kusnezoffii of Ranunculaceae, and has effects of dispelling pathogenic wind, removing dampness, warming channels and relieving pain.

In the embodiment, the radix anisodii acutanguli, the yellow-life pill, the fructus cannabis, the raw radix aconiti and the raw radix aconiti agrestis are added on the basis of the oral prescription in the embodiment 1, so that the effective components in the plaster are easier to be absorbed through the skin under the synergistic action, and the drug effect of the external plaster is obviously improved.

Example 6

The embodiment provides a traditional Chinese medicine external ointment for setting a bone, which comprises the following components in parts by weight: the traditional Chinese medicine oral prescription for setting bones provided in embodiment 2 comprises 100g of camphor 15g, elderberry root bark 15g, radix anisodii acutanguli 30g, yellow-rooted salvia 15g, fructus cannabis 15g, raw radix aconiti 10g, raw radix aconiti agrestis 10g, native copper calcined with vinegar 15g, dragon's blood 10g, mature vinegar 100g, minium 200g and sesame oil 500 g.

Example 7

The embodiment provides a traditional Chinese medicine external ointment for setting a bone, which comprises the following components in parts by weight: the traditional Chinese medicine oral prescription for setting bones provided in embodiment 3 comprises 150g, 0.25g of camphor, 0.25g of elderberry root bark, 0.4g of anisodus acutangula, 0.25g of yellow birthday pellet, 0.25g of fructus cannabis, 0.15g of radix aconiti, 0.15g of raw radix aconiti agrestis, 0.25g of native copper calcined by vinegar, 0.15g of dragon's blood, 150g of mature vinegar, 300g of minium and 600g of vegetable oil.

Example 8

A method for preparing the external traditional Chinese medicine paste for setting bones provided in embodiment 6 or embodiment 7, comprising the following steps:

step a, soaking elderberry root bark, yellow-life lead, fructus cannabis, raw radix aconiti agrestis and half part of radix anisodii acutanguli in sesame oil for 10 days;

b, pouring the sesame oil and the medicinal materials soaked in the step a into a copper pot, decocting the sesame oil and the medicinal materials for 10-15 minutes by using a small fire, keeping the oil temperature at about 100 ℃ at the moment to extract the active ingredients in the medicinal components, then heating the oil to about 160 ℃ by using a medium fire, decocting the oil for 25-35 minutes until the medicinal liquid is black and yellow, filtering the medicinal liquid to remove dregs, and collecting the medicinal oil;

c, boiling the medicine oil collected in the step b with medium fire to enable the oil temperature to rise to 260 +/-5 ℃, changing to big fire when the oil flower rolls and rises light smoke, quickly pouring the minium into the medicine oil within 10 seconds under the stirring state, quickly rising the oil temperature to about 310 ℃, boiling to severe smoke within 15-30 seconds, immediately taking the pot out of the fire, stopping heating, slowly pouring the plaster materials in the pot into cold water at 4-10 ℃ for cooling, stirring while pouring, then changing the cold water every 10 minutes until the plaster materials are cooled to room temperature, changing the cold water every 2 hours, cooling for 6-24 hours, and taking out the plaster materials;

step d, burning the native copper till the native copper is fully red, then immersing the native copper into the edible mature vinegar, and cooling the native copper to obtain vinegar calcined native copper; crushing the vinegar calcined native copper, the dragon's blood and the remaining half of the acutangular anisodus root into 100-120 meshes;

and c, putting the plaster material obtained in the step c and mature vinegar into a pot, re-melting the plaster material by using a small fire, adding camphor, the Chinese medicinal oral preparation for setting the fracture provided in the embodiment 2, the smashed vinegar calcined native copper, dragon's blood and the rest half part of the thirteen medical ingredients, stirring uniformly, stopping heating, and cooling for later use.

When the plaster is used, the plaster is heated to melt, the plaster is coated on non-woven fabric according to the size required by a focus to prepare the plaster, each plaster is 10-15 g in weight and is applied to an affected part, and the plaster is replaced every 2-3 days.

Clinical case statistics

1. Cases and methods

Randomly selecting 200 cases from 2010 to 2020, and determining fracture according to clinical manifestations and imaging examination, wherein 120 cases are male and 80 cases are female; the minimum age is 15 years, the maximum age is 75 years, and the average age is 45.5 years; the selected cases are compared by statistical analysis in the aspects of sex, age, disease course and the like. The oral prescription and the external ointment for setting the fracture are pertinently given during treatment, and the oral administration and the external application are guided.

2. Determination of therapeutic effect

And (3) curing: the fracture is completely healed, and the fracture line disappears;

the effect is shown: obvious callus formation at the fracture end, and fuzzy fracture line;

the method has the following advantages: obvious callus formation at the fracture end, narrowing of fracture gap and no abnormal movement;

and (4) invalidation: no obvious callus formation at the fracture end, no change from the fracture line before treatment to the fracture line after cleaning.

3. Statistical results

TABLE 1 clinical case statistics

	Applying the medicine for 15 days	Applying the medicine for 30 days	Applying the medicine for 45 days	Applying the medicine for 60 days
					Cure of disease	37 examples of	126 examples of	187 cases	200 examples of
Show effect	75 cases of	46 examples of	Example 13	-
					Is effective	82 examples of	28 examples of	-	-
Invalidation	6 examples of	-	-	-
					Total effective rate	97.5％	100％	100％	100％

The total effective rate (%) - (number of cure cases + number of significant cases + number of effective cases)/total number of cases × 100%

The statistical results of the data in the table 1 show that the traditional Chinese medicine oral prescription and the external ointment for setting the fracture provided by the invention realize the technical effects of quick fracture setting effect and obvious curative effect, the cure rate can reach 18.5% after 15 days of application, and the total effective rate reaches 97%; the cure rate is increased to 63 percent after 30 days of drug application, which indicates that the bone callus can be formed basically in 30 days of drug application for fracture patients, most fractures can be healed, and the total effective rate reaches 100 percent; the cure rate is increased to 93.5 percent after 45 days of application, and the cure rate can reach 100 percent after 60 days of application.

Typical clinical cases

Case 1

Yuanyan celery, female, 67 years old. The femoral trochanter fracture is diagnosed as the femoral trochanter fracture due to the falling injury in 2018, 9 and 10 days, only the leg of the patient is placed right without reduction and fixation, the external ointment provided by the embodiment 6 of the invention is externally applied, two patches are applied at one time, the patch is attached to the fracture part, the patch is changed once in two days, and the oral prescription provided by the embodiment 2 is orally taken 10g each time by yellow wine before breakfast and supper every day.

The patient heals clinically on the 45 th day of drug application and can get out of bed to stand; the walking stick can lean on the crutch to exercise and walk on the 50 th day after the pesticide is applied; fig. 1 is an X-ray film of the femoral trochanter fracture after the healing of the femoral trochanter fracture after 60 days of drug application, and the disappearance of fracture lines and calcification of callus into bone can be seen from the X-ray film. The patient can be healed by continuously applying the medicine for 90 days without leaning on walking.

Case 2

Xie Xiao Yi, woman, age 39. In 2018, 8, 26 months and 26 days after the injury, the fracture and slight dislocation of the middle humerus are confirmed, and fig. 2 is an X-ray film of the middle humerus fracture caused by the injury of case 2. The oral administration provided in example 2 was administered before reduction by manipulation, and the pain of the patient was significantly reduced during bone setting and disappeared after reduction. The external ointment provided by the embodiment 6 of the invention is replaced once in three days after reduction by manipulation, splint fixation and external application, and the oral prescription provided by the embodiment 2 is orally taken with yellow wine 10g each time before breakfast and supper every day. The pain disappears after the patient takes the medicine for 30 minutes for the first time, and the swelling gradually subsides after 12 hours.

The patient was reexamined 30 days after application, the X-ray film is shown in figure 3, the fracture gap was reduced, the fibrous tissue was connected, the clinical healing was achieved, the oral preparation was stopped, the external ointment was continuously applied, the patient was changed once every two days, the 45 th healing was achieved, and the splint fixation was released.

Case 3

Xujing bao (male, 46 years old). And 3, in 2019, the patient is admitted 30 days in 3 months, and the right femoral neck fracture is diagnosed by X line. After the surgical reduction and internal fixation, the oral formulation provided in example 3 was taken 10g each time with yellow wine before breakfast and supper every day. The pain of the patient disappears after the patient is taken for 30 minutes for the first time, the swelling of the affected part is gradually subsided after 12 hours, the patient is clinically healed after the patient is taken for 30 days, and the patient is healed after the patient is taken for 45 days.

Case 4

Luqingchun, male, 55 years old. The patient was admitted to the hospital in 2019 at month 4 and day 19, and the fracture of the metatarsal bone of the right foot 4, 5 was diagnosed by X-ray. The oral administration provided in example 2 was administered before reduction by manipulation, and the pain of the patient was significantly reduced during bone setting and disappeared after reduction. The external fixation is performed by reduction by a manipulation, and the external ointment provided in example 6 is externally applied, and the treatment is changed once in 3 days; the oral formulation provided in example 2 was taken orally with yellow wine 10g each time, daily before breakfast and supper. The patient can immediately stop pain after the first application, the swelling and pain disappears after 12 hours, the clinical healing is realized after 20 days of application, the external fixation is released, and the healing is realized after 30 days of application.

Case 5

In Junjie, man, age 46. And (4) admission is carried out on 14 days 2 and 2 in 2020, and the comminuted fracture of the right tibiofibula is diagnosed by X line. The oral preparation provided in example 2 was orally administered with 10g of yellow wine each time before breakfast and supper every day after surgical reduction and internal fixation. The pain of the patient disappears 30 minutes after the patient takes the medicine for the first time, the swelling gradually subsides within 12 hours, the clinical healing is realized within 30 days after the medicine is applied, and the clinical healing is realized within 45 days after the medicine is applied.

Case 6

Prune forest, male, 47 years old. The patient is admitted to the hospital in 2019, 12 and 1, and the fracture of the tenth left rib is diagnosed by X-ray. Fixed by a bandage, the external ointment provided in example 7 is externally applied, the ointment is changed every two days, and the oral prescription provided in example 3 is orally taken with yellow wine every day, 10g each time, before breakfast and supper. The patient can immediately stop pain after the first application, the swelling and pain disappears after 12 hours, the clinical healing is realized on the 15 th day after the application, and the healing is realized after 20 days after the application.

Case 7

Xiaoyuying, female, 57 years old. And hospital admission is carried out in 2019, 12 months and 2 days, and the comminuted fracture of the scapula is diagnosed by X rays. Fixed by a bandage, the external ointment provided in example 7 is externally applied, the ointment is changed every two days, and the oral prescription provided in example 3 is orally taken with yellow wine every day, 10g each time, before breakfast and supper. The pain of the patient is stopped immediately after the first medication, and the swelling is gradually reduced within 12 hours. The clinical healing is realized after 20 days of drug application, and the healing is realized after 30 days of drug application.

The typical cases prove that the oral prescription and the external ointment for setting the bone provided by the invention have obvious quick analgesic effect; the medicine can obviously relieve swelling and pain after being applied for 12 hours, and has obvious effects of promoting blood circulation and removing blood stasis; meanwhile, after the medicine is applied, the patient can realize rapid callus generation, so that clinical healing is achieved, and the medicine has remarkable effects of growing muscle and bone.

Claims

1. The oral traditional Chinese medicine for setting bones is characterized in that the raw materials comprise the following components in parts by weight: 1-3 parts of wine-roasted rhubarb, 1-3 parts of vinegar-roasted frankincense, 1-3 parts of vinegar-roasted myrrh, 1-3 parts of catechu, 2-5 parts of teasel root, 3-8 parts of salt-fried achyranthes bidentata, 2-5 parts of rhizoma drynariae, 2-5 parts of sand-fried cibotium villosum, 2-5 parts of ground beetle, 1-3 parts of fried peach kernel, 1-3 parts of safflower, 2-5 parts of yam rhizome purification powder, 3-8 parts of elderberry root bark, 2-5 parts of cucumber seed, 1-3 parts of pseudo-ginseng, 1-3 parts of dragon blood, 3-8 parts of chicken branch inner skin, 2-5 parts of vinegar-calcined native copper, 1-3 parts of vinegar-dried, 1-3 parts of calcium carbonate, 1-3 parts of dogwood, 1-3 parts of prepared rehmannia root and 1-3 parts of goat blood; the vinegar dried powder is obtained by drying precipitate in edible mature vinegar left after forging Pyritum with vinegar for many times.

2. The oral traditional Chinese medicine for setting bones according to claim 1, which is characterized in that the raw materials comprise the following components in parts by weight: 2 parts of wine-fried rhubarb, 2 parts of vinegar-fried frankincense, 2 parts of vinegar-fried myrrh, 2 parts of catechu, 3 parts of teasel root, 4 parts of salt-fried achyranthes root, 3 parts of drynaria rhizome, 3 parts of sand-fried cibotium barometz, 3 parts of ground beeltle, 2 parts of fried peach seed, 2 parts of safflower, 3 parts of yam purified powder, 4 parts of elderberry root bark, 3 parts of cucumber seed, 2 parts of pseudo-ginseng, 2 parts of dragon's blood, 4 parts of chicken strip inner skin, 3 parts of vinegar-calcined native copper, 2 parts of vinegar-dried, 2 parts of calcium carbonate, 2 parts of dogwood, 2 parts of prepared rehmannia root and 2 parts of goat blood.

3. The oral traditional Chinese medicine for setting bones of claim 1, wherein the dosage form of the oral traditional Chinese medicine is powder, tablet, granule, capsule, pill or oral liquid preparation.

4. A method for preparing an oral traditional Chinese medicine for bone knitting according to claim 1 or 2, characterized by comprising the following steps:

step four, uniformly mixing the crushed components obtained in the step two and the step three to obtain the oral traditional Chinese medicine for setting the fracture.

5. The traditional Chinese medicine external ointment for setting bones is characterized by comprising the following raw material medicines in parts by weight: the bone-setting oral traditional Chinese medicine obtained according to claim 4 comprises 1-3 parts of camphor, 0.2-0.5 part of elderberry root bark, 0.2-0.5 part of anisodus acutangulus, 0.4-0.8 part of anisodus acutangulus, 0.2-0.5 part of yellow lead, 0.2-0.5 part of fructus cannabis, 0.1-0.3 part of radix aconiti agrestis, 0.2-0.5 part of vinegar calcined native copper, 0.1-0.3 part of dragon's blood, 1-3 parts of mature vinegar, 3-6 parts of minium and 10-12 parts of vegetable oil.

6. The traditional Chinese medicine external ointment for setting bones as claimed in claim 5, which is characterized in that the raw material medicines comprise the following components in parts by weight: the oral traditional Chinese medicine for setting bones obtained in claim 4 comprises 2 parts of camphor, 0.3 part of elderberry root bark, 0.3 part of anisodus acutangulus, 0.6 part of yellow-headed lead, 0.3 part of fructus cannabis, 0.2 part of unprocessed radix aconiti agrestis, 0.3 part of vinegar calcined pyrite, 0.2 part of dragon's blood, 2 parts of mature vinegar, 4 parts of minium and 10 parts of vegetable oil.

7. A method for preparing the externally applied traditional Chinese medicine ointment for setting bones as claimed in claim 5 or 6, which is characterized by comprising the following steps:

b, pouring the oil and the medicine soaked in the step a into a copper pot, decocting for 10-15 minutes with slow fire, then decocting for 25-35 minutes with medium fire until the medicine liquid is black and yellow, filtering and collecting the medicine oil;

c, boiling the medicinal oil collected in the step b with medium fire, changing the fire to big fire when the oil flower rolls and rises to light smoke, pouring the minium into the medicinal oil within 10 seconds under the stirring state, boiling until the smoke is generated, immediately stopping heating, pouring the plaster materials in the pot into cold water for cooling, and taking out the plaster materials after cooling for 6-24 hours;

and d, putting the plaster material obtained in the step c and mature vinegar into a pot, re-melting the plaster material by using a small fire, adding camphor, the oral traditional Chinese medicine for setting the fracture obtained in the claim 4, vinegar calcined native copper, dragon's blood and the rest half part of the thirteen medicines, stirring uniformly, stopping heating, and cooling for later use.

8. The method for preparing a topical Chinese medicinal paste for setting fracture according to claim 7, wherein said Pyritum calcined with vinegar in step d is prepared by calcining Pyritum to red, soaking in edible old vinegar, and cooling to obtain Pyritum calcined with vinegar.

9. The method for preparing a topical Chinese medicinal paste for setting fracture according to claim 8, wherein Pyritum calcined with vinegar, Anisodus acutangulus and sanguis Draxonis are pulverized into 100-120 mesh powder in step d.