CN102370861A - Emulsifiable paste for treating infantile eczema - Google Patents
Emulsifiable paste for treating infantile eczema Download PDFInfo
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- CN102370861A CN102370861A CN2011103543913A CN201110354391A CN102370861A CN 102370861 A CN102370861 A CN 102370861A CN 2011103543913 A CN2011103543913 A CN 2011103543913A CN 201110354391 A CN201110354391 A CN 201110354391A CN 102370861 A CN102370861 A CN 102370861A
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Abstract
The invention relates to an emulsifiable paste for treating infantile eczema. Monoglyceride, 1802, 16-18 alchol, simethicone, white oil, 5013, propylparaben, propylene glycol, azone, chlortrimeton, a liquorice extracting solution, boric acid, propylene glycol, menthol crystal, ureidohydantoin, methylparaben, glycerol, deionized water, 2901 and an aloe extracting solution are diffused in an emulsifiable paste substrate to form the emulsifiable paste for treating the infantile eczema. By using the emulsifiable paste for treating the infantile eczema, through the combination of traditional Chinese medicines and western medicines with accessory ingredients, the purpose of treating the infantile eczema is achieved; furthermore, the curative effect is good; and the use is convenient, safe and reliable. The emulsifiable paste for treating the infantile eczema is suitable to be used as a medicine for treating the infantile eczema.
Description
Technical field
What the present invention relates to is a kind of medicine that is used to treat disease, specifically a kind of emulsifiable paste that is used to treat infantile eczema.
Background technology
Infantile eczema such as sends out around forehead eyebrow, two cheeks, scalp, auricle well at the women's head-ornaments position, spreads later on gradually around neck, shoulder, the back of the body, extremity, anus, skin wrinkle such as pudendum position gets along, even can involve whole body.Because eczema is with very itching, child uses the position of holding erythra in hand, causes the skin ulceration.During recumbency, child can rub the brain rear portion on medicated pillow, and it is bald to form pillow; In the time of on all fours, it is antipruritic that child uses the bed sheet friction face; When having in arms, child can nestle to rub at the shoulder of nursing and rub face.The sick child is normal because of autonomous pruritus dysphoria, cries and screams night so that influence is slept, again owing to children's often can cause bacterial skin infections the state of an illness is further increased the weight of with holding in hand to itch.
Can be divided into three types according to eczema performance difference:
1. exudative type is claimed wet type again, is main to ooze out, and takes place rotten to the corn;
2. dry type is main with bran skin appearance desquamation;
3. seborrhea type, exudate picture pool is pretended, and gargalesthesia is not quite heavy.
A kind of dermatosis that cradle is common, eczema just can take place in 2～3 months baby, alleviates gradually later in 1 years old, great majority can spontaneous recovery after 2 years old, but minority can be extended to the child or the childhood period.There is the child of infantile eczema that other anaphylactic diseases take place later on easily, like asthma, allergic rhinitis, anaphylaxis conjunctivitis etc.
(1) drying type: eczema shows as in red pimple, and red swelling of the skin can be arranged, and bran skin appearance desquamation and dryness joint crust phenomenon is arranged on the pimple, itches very much.
(2) seborrhea type: eczema shows as erubescence, oozes out faint yellow fat property liquid on the little maculopapule and covers on the erythra, forms thicker yellow crust later on, is difficult for removing, and with by the crown and eyebrow border, the nose, see behind the ear, but gargalesthesia is not too obvious more.
(3) exudative type: be more common in more fat baby, chickenpox and erythema are arranged between red rash, skin histology swelling phenomenon can be arranged, itch very much, have yellow slurry to ooze out or hemorrhage after the scratching, erythra can spread to trunk, extremity and whole body, and secondary skin infection easily.
Employed medicine and method during treatment:
(1) Oleum Radix Arnebiae (Oleum Radix Lithospermi): Radix Arnebiae (Radix Lithospermi) 9 gram, with an amount of burned of Oleum sesami, treat that oily purple pulls Radix Arnebiae (Radix Lithospermi) out and get final product, every day, several was coated with the affected part with oil.
(2) egg heats up in a steamer oil: 7 in egg, and boil and get egg yolk, put Oleum Sesami 50～100 grams in the pot, slow fire is endured out oil in the egg yolk, treats that egg yolk is burnt pasty state and gets final product, and gets oil and is coated with the affected part frequently.
(3) an amount of porphyrize powder of Os Sepiae looses and applies the eczema place, and be applicable to the person of oozing out every day for several times.
(4) Conch Meretricis seu Cyclinae looses: Conch Meretricis seu Cyclinae 100 grams, Fructus Zanthoxyli 50 grams, Calomelas 3 grams.Conch Meretricis seu Cyclinae is broken into thin piece, fry, go into Fructus Zanthoxyli,, go in the hermetically sealed can and seal up for safekeeping to play cigarette degree of being with frying to black to golden yellow.Added Calomelas, grind to the powder altogether in 1st.Oleum sesami is transferred and is put on the skin.
(5) Radix Bupleuri cream: Radix Bupleuri 30 grams, fragrant core 2 grams, Flos Chrysanthemi 3 grams, Fructus Forsythiae 3 grams, Radix Glycyrrhizae 3 grams, Indigo Naturalis 30 grams.Grind, hundred vaseline are accompanied into paste, and directly the clearing away heat-damp and promoting diuresis removing heat from blood is embrocated in medicine-feeding.Be applicable to the dry and cracked and the infected of chronic eczema.
(6) wrap cloud cream: Colophonium end 60 grams, sulfur end 30 grams grind well, and Oleum Sesami mixes pasty state, spreads out on gauze, to be rolled into like the thick bar of finger, tightens with line, reenters in the Oleum Sesami to steep 1 day, takes out.With one of fire point, follow down with thick bowl.The cloth ash cuts off successively, get drip medicine oil, use outward a night in the boshing water, be fit to companion local infection person especially.
(7) Rhizoma Solani tuber osi is cleaned, and chopping is mashed, and applies the affected part, with the gauze wrapping, whenever changes dressings round the clock 2～3 times.
1) it is sure that the medicine that contains 17-hydroxy-11-dehydrocorticosterone is put the eczema curative effect outward on the skin, can select light disease or the little eczema of scope; To the big eczema of area or the eczema of outbreak repeatedly,, have the side effect of whole body and local skin if frequent or a large amount of or prolonged application contains the medicine of 17-hydroxy-11-dehydrocorticosterone.
2) contain the local skin side effect of corticosteroid drug outstanding be drug dependence dermatitis and knock-on dermatitis.The drug dependence dermatitis refers to the eczema corticosteroids medicine of can not stopping using.After the knock-on dermatitis referred to the 17-hydroxy-11-dehydrocorticosterone external, the eczema state of an illness can take a turn for the better rapidly, in case but after the drug withdrawal; A couple of days the innerlich anwenden position crimson, tenderness, pruritus, breach, desquamation can take place so that pustule takes place, eczema more increases the weight of; After recoating with hormone, the state of an illness takes a turn for the better very soon or disappears; As drug withdrawal again, the knock-on dermatitis is sent out again, and more serious than in the past.
So avoid the heavy dose of external corticosteroids of long period or short-term medicine as far as possible.
Present employed Chinese medicine preparation usually preparation is cumbersome, be unfavorable for using, though and hormone medicine has better therapeutic effect, cause recurrence easily or develop into other disease.
Infantile eczema mainly occurs in a kind of acute or subacute eczema of baby's women's head-ornaments portion, is commonly called as the milk rash, and its sick complicacy and baby are to allergy such as milk, egg, fish and shrimp, cod-liver oil, and the digestive functional disturbance bacterial infection reaches contactant allergy or stimulates relevant.
Giving birth to back morbidity in 1-5 month, erythra is sent out in face well more, and the minority case can betide the trunk extremity, shows as erythema, pimple, papulovesicle, and blister and erosion are oozed out, and sepage is dry to form the incrustation that differs of yellow thickness, and skin lesion merges indefinite border in blocks.
Treatment is many clinically wipes outward with Calamine Lotion or glucocorticoid cream, no specific aim treatment.
Summary of the invention
For the medicine that can make made treatment infantile eczema has good effect, can not produce adverse effect again, and also easy to use, the present invention proposes a kind of emulsifiable paste that is used to treat infantile eczema.This emulsifiable paste is dispersed in the emulsifiable paste matrix by medicine, ancillary drug and adjuvant to be formed, and through being used of institute's medicament and ancillary drug and adjuvant, solves the technical problem of infantile eczema treatment.
The scheme that technical solution problem of the present invention is adopted is:
Monoglyceride, 1802,16-18 alcohol, dimethicone, white oil, 5013; Propylparaben, propylene glycol, azone, chlorphenamine, Radix Glycyrrhizae extract, boric acid; Propylene glycol, Mentholum, allantoin, methyl hydroxybenzoate, glycerol; Deionized water, 2901, Aloe extraction solution is dispersed in the emulsifiable paste matrix, consists of the emulsifiable paste of treatment infantile eczema.
Good effect, the present invention treats the combination of infantile eczema emulsifiable paste through Chinese medicine and Western medicine and auxiliary agent, reach the purpose of treatment infantile eczema, and therapeutic effect is good, and convenient the use is safe and reliable.Suitable drug use as the treatment infantile eczema.
The specific embodiment
Medicine is formed:
Monoglyceride 1～2.5 gram, 1,802 1～2 grams, 16-18 alcohol 1～3 gram, dimethicone 0.5～1 gram, white oil 3～8 grams; 5,013 2～4 grams, propylparaben 0.01～0.05 gram, propylene glycol 1～3 gram, azone 1～3 gram; Chlorphenamine 0.1～0.3 gram, Radix Glycyrrhizae extract 2～3 grams, boric acid 1～2 gram, propylene glycol 1～2 gram; Mentholum 0.01～0.05 gram, allantoin 0.1～0.2 gram, methyl hydroxybenzoate 0.1～0.2 gram, glycerol 3～5 grams; Deionized water 50～80 grams, 2,901 1～3 grams, Aloe extraction solution 3～5 grams are dispersed in 100 milliliters of emulsifiable paste matrixes.
The effect of each constituent:
Monoglyceride: nonionic emulsifier is the primary emulsion and the co-emulsifier of emulsion.
1802: also be golden extra large phosphate ester emulsifying agent, zest is little, has the stable emulsion effect.
16-18 alcohol: excipient, lubricant, can improve the flexibility and the lubricity of emulsifiable paste.
Dimethicone: protective agent, excipient, anti-ultraviolet stimulates.
White oil: the liquid oil skin moisturizing agent that emulsifiable paste is commonly used.
5013: the different lactone of myristic acid, excipient, dispersant and fixastive.
Propylparaben: medicine is used antiseptic always.
Propylene glycol: heat preserving agent, penetrating agent, can dissolve multiple medicine.
Azone: penetrating agent has tangible transdermal to help the effect of oozing to medicine.
Chlorphenamine: H1 receptor antagonist, antiallergic.
Radix Glycyrrhizae extract: antiinflammatory, antiallergic, antiviral, play the skin moistening effect.
Boric acid: antiseptic and inhibiting bacteria function, in medicament, regulate the pH value effect.
Vitamin E: skin moistening, protectiving ultraviolet damage, increase the capillary of skin blood flow, increase blood vessel to cold resistance.
Mentholum: refrigerant, antipruritic, play osmosis.
Allantoin: wetting agent, keratoplastics, the ability of short keratoprotein bound water increases skin care.
Methyl hydroxybenzoate: medicine is used antiseptic always.
Glycerol: heat preserving agent, excipient, stabilizing agent.
Deionized water: get the purification deionized water and be heated to 90
0C continues the 20min sterilization, reduces to 80
0The subsequent use work of C is transferred diuretic phase Emulsion.
2901: anti-skin allergy liquid, can reduce sensitization, and have antiinflammatory, fall stimulation.
Aloe extraction solution: antiinflammatory, shrink, preserve moisture, play radiation resistance.
The mutual synergism of each constituent:, infantile eczema is produced the effect of Comprehensive Treatment and produces definite curative effect through the mutual synergism of antipruritic, antiinflammatory, Claritin and adjuvant.
Test data and test effect:
Clinical trial: infantile eczema test of cure case 150 examples, wherein male 141 examples, women 9 examples, 30 days to 5 years old age, the course of disease one day to a year.150 routine patients are divided into three groups by the digital random method, and A organizes 50 examples, male 49 examples, and women 1 example, B organize 50 examples, male 45 examples, women 5 examples, C organizes 50 examples, male 47 examples, women 3 examples.
Therapeutic Method: A group external emulsifiable paste of the present invention is coated with outward for 2 times every day sooner or later, and B organize except that external eczema emulsifiable paste, adds that the oral youngster of pouncing on is quick by age to give two milligrams to four milligrams, and days three times oral, and C organizes that the only oral youngster of pouncing on is quick by age to give 2 to 4 milligrams, and every day three times is oral.
The curative effect judgment criteria:
Treat after 5 days, clinical efficacy takes a turn for the better by by produce effects, passes judgment on for invalid 3 grades.
Produce effects: erythema is oozed out the infringement of incrustation property and is obviously disappeared, and no pruritus does not have new skin lesion and occurs.
Take a turn for the better: erythema is oozed out the infringement of incrustation property and is obviously alleviated, and accompanies slight pruritus once in a while, does not have new skin lesion and occurs.
Invalid: erythema is oozed out the infringement of incrustation property not to be had and obviously alleviates, still with pruritus or there is new skin lesion to occur.
Produce effects is counted effective percentage with the percentage ratio of the routine number that takes a turn for the better.
Statistical method: The data X 2 test.
The result:
Only adopt the clinical effectiveness of treatment group of the oral youngster's of pouncing on sensitizing drug undesirable, and that external emulsifiable paste of the present invention and external emulsifiable paste of the present invention add patient's curative effect of the quick medicine of the oral youngster of pouncing on is obvious.
3 groups of infantile eczema patients' clinical efficacy contrasts as follows:
| Group | The example number | Produce effects | Take a turn for the better | Invalid | Effective percentage (%) | X 2Value | The P value |
| The A group | 50 | 31 | 17 | 2 | 96 | 3.0624 | 0.066 |
| The B group | 50 | 39 | 40 | 1 | 98 | 45.388 *△ | 0.015 |
| The C group | 50 | 7 | 21 | 22 | 56 | 32.245 * | 0.019 |
* compare with the A group, △ B group is organized relatively with C.
Claims (1)
1. emulsifiable paste that is used to treat infantile eczema is characterized in that:
Monoglyceride 1～2.5 gram, 1,802 1～2 grams, 16-18 alcohol 1～3 gram, dimethicone 0.5～1 gram, white oil 3～8 grams; 5,013 2～4 grams, propylparaben 0.01～0.05 gram, propylene glycol 1～3 gram, azone 1～3 gram, chlorphenamine 0.1～0.3 gram; Radix Glycyrrhizae extract 2～3 grams, boric acid 1～2 gram, propylene glycol 1～2 gram, Mentholum 0.01～0.05 gram; Allantoin 0.1～0.2 gram, methyl hydroxybenzoate 0.1～0.2 gram, glycerol 3～5 grams, deionized water 50～80 grams; 2,901 1～3 grams, Aloe extraction solution 3～5 grams are dispersed in 100 milliliters of emulsifiable paste matrixes, consist of the emulsifiable paste of treatment infantile eczema.
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| CN2011103543913A CN102370861A (en) | 2011-11-10 | 2011-11-10 | Emulsifiable paste for treating infantile eczema |
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| CN2011103543913A CN102370861A (en) | 2011-11-10 | 2011-11-10 | Emulsifiable paste for treating infantile eczema |
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| CN102370861A true CN102370861A (en) | 2012-03-14 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274663A (en) * | 2014-05-25 | 2015-01-14 | 许春晖 | Paste for treating eczema |
| CN104587279A (en) * | 2015-02-13 | 2015-05-06 | 广东华润顺峰药业有限公司 | Oil-in-water type menthol ointment and preparation method thereof |
| CN105106234A (en) * | 2015-09-28 | 2015-12-02 | 兰晶 | Anti-allergy and anti-inflammatory external preparation special for treatment of allergic dermatitis |
| CN105748573A (en) * | 2016-03-10 | 2016-07-13 | 广西大学 | Radix Glycyrrhizae cream and preparation method thereof |
| CN106692161A (en) * | 2016-12-23 | 2017-05-24 | 林维星 | Medicine for treating eczema and preparation method of medicine |
| CN107669834A (en) * | 2017-09-20 | 2018-02-09 | 四川香龙丹医药科技有限公司 | One kind treats children and the pregnant, the food in one's mouth dermopathic externally-applied medicinal composition of phase women |
-
2011
- 2011-11-10 CN CN2011103543913A patent/CN102370861A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274663A (en) * | 2014-05-25 | 2015-01-14 | 许春晖 | Paste for treating eczema |
| CN104587279A (en) * | 2015-02-13 | 2015-05-06 | 广东华润顺峰药业有限公司 | Oil-in-water type menthol ointment and preparation method thereof |
| CN104587279B (en) * | 2015-02-13 | 2018-05-04 | 广东华润顺峰药业有限公司 | Oil-in-water type menthol ointment and preparation method thereof |
| CN105106234A (en) * | 2015-09-28 | 2015-12-02 | 兰晶 | Anti-allergy and anti-inflammatory external preparation special for treatment of allergic dermatitis |
| CN105748573A (en) * | 2016-03-10 | 2016-07-13 | 广西大学 | Radix Glycyrrhizae cream and preparation method thereof |
| CN106692161A (en) * | 2016-12-23 | 2017-05-24 | 林维星 | Medicine for treating eczema and preparation method of medicine |
| CN107669834A (en) * | 2017-09-20 | 2018-02-09 | 四川香龙丹医药科技有限公司 | One kind treats children and the pregnant, the food in one's mouth dermopathic externally-applied medicinal composition of phase women |
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Application publication date: 20120314 |