CN106692161A - Medicine for treating eczema and preparation method of medicine - Google Patents
Medicine for treating eczema and preparation method of medicine Download PDFInfo
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- CN106692161A CN106692161A CN201611205242.XA CN201611205242A CN106692161A CN 106692161 A CN106692161 A CN 106692161A CN 201611205242 A CN201611205242 A CN 201611205242A CN 106692161 A CN106692161 A CN 106692161A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the technical field of medicines and relates to a medicine for treating eczema and a preparation method of the medicine. The medicine for treating eczema is specifically prepared from raw materials through mixing in parts by weight as follows: oil phase components: bleached beeswax, C12-15 benzoate, isopropyl myristate, melaleuca alternifolia oil, stearic acid, glycyrrhetinic acid, lanolin and shea butter; water phase components: glycerin, diphenhydramine hydrochloride and purified water; pharmaceutically active components: chlorphenamine maleate, propylene glycol, menthol, camphor, borneol and paeonol. The medicine has the benefits as follows: melaleuca alternifolia oil, menthol, camphor, borneol and other aromatic materials assisting in medicine penetration are added to the medicine and can help glycyrrhetinic acid, chlorphenamine maleate, paeonol and the like to be imported into corium layers of skin, so that the effects of preventing allergy and resisting itching are quickly realized, symptoms such as erythema, skin lesions and the like can be relieved for eczema patients.
Description
Technical field
The present invention relates to pharmaceutical technology field, it is related to a kind of treat medicine of eczema and preparation method thereof.
Background technology
Eczema is a kind of scytitis reaction of the acute pruritus caused by various internal and external factors.Divide acute, subacute, slow
Three phases of property.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plumpness.Some patients directly translate into chronic eczema.Skin damaged has
The features such as polymorphy, symmetry, itch and easy recurrent exerbation.
The externally applied drug of current eczema, more based on hormone, is aided with antibiotic, and this kind of medicine side effect is big, repeated multiple times to use,
Easily switch to steroid dependent dermatitis, treatment is got up increasingly difficult.
The content of the invention
To solve defect present in above-mentioned prior art, it is an object of the present invention to provide a kind of non-antibiotic, instant effect
Treat medicine of eczema and preparation method thereof.
The technical scheme is that providing a kind of medicine for treating eczema, the raw material mixing of following weight portion is specifically included
Form:
Oil phase component:1-3 parts of cera alba, 3-5 parts of C12-15 benzoic ether, 1-3 portions of nutmeg beans isopropyl propionate, 1-4 parts mutually
Leaf cajeput oil, 2-5 part stearic acid, 0.5-1 parts of enoxolone, 1-3 parts of lanolin, 2-4 parts of shea butter;
Water phase components:4-7 parts of glycerine, 1-3 parts of bagodryl hydrochloride, 60-80 parts of purified water;
Medicine activity component:3-5 parts of chlorphenamine maleate, 5-10 parts of propane diols, 3-5 parts of menthol, 3-5 parts of camphor,
1-3 parts of borneol, 1-3 parts of Paeonol.
Preferably, in the medicine of above-mentioned treatment eczema, the weight of the oil phase component, water phase components and medicine activity component
Amount part is compared:20 parts of oil phase components, 70 parts of water phase components, 20 parts of medicine activity components.
Another technical scheme of the invention is to provide a kind of preparation method of the medicine for treating eczema, is comprised the following steps:
1) weigh oil phase component and be heated to 80-85 DEG C, stir 20-25min, obtain oil mixture;The oil phase component bag
Include the raw material of following weight portion:1-3 parts of cera alba, 3-5 parts of C12-15 benzoic ether, 1-3 portions of nutmeg beans isopropyl propionate, 1-4 parts
Titrol, 2-5 part stearic acid, 0.5-1 parts of enoxolone, 1-3 parts of lanolin, 2-4 parts of shea butter;
Weigh water phase components and be heated to 80-85 DEG C, stir 20-25min, obtain aqueous mixture;The water phase components include
The raw material of following weight portion:4-7 parts of glycerine, 1-3 parts of bagodryl hydrochloride, 60-80 parts of purified water;
Weigh medicine activity component and be heated to 50-60 DEG C, stir 20-25min, obtain aqueous mixture;Pharmaceutical activity mixes
Thing;The medicine activity component includes the raw material of following weight portion:3-5 parts of chlorphenamine maleate, 5-10 parts of propane diols, 3-5
Part menthol, 3-5 parts of camphor, 1-3 parts of borneol, 1-3 parts of Paeonol;
2) raw material of following weight part ratio is taken:12-43 parts of oil mixture, 65-90 parts of aqueous mixture and 16-31 parts of medicine
Thing active mixture, aqueous mixture is slowly added into by oil mixture at a temperature of 80-85 DEG C, is kept stirring for 20-30 minutes;
60-65 DEG C is cooled to, pharmaceutical activity mixture is slowly added to, is incubated, persistently stir 20-30 minutes to obtain medicinal mixture;
3) medicinal mixture is cooled to 35-40 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 4000rpm,
Homogenizing time is 10-15 minutes;Take the dish out of the pot the medicine for being aged and must treating eczema.
Preferably, in the preparation method of the medicine of above-mentioned treatment eczema, the step 2) in oil mixture, water mutually mix
The weight part ratio of compound and pharmaceutical activity mixture is:20 parts of oil mixtures, 70 parts of aqueous mixtures, 20 parts of pharmaceutical activity are mixed
Compound.
Preferably, in the preparation method of the medicine of above-mentioned treatment eczema, the step 2) in by oil mixture in 80-
When being slowly added at a temperature of 85 DEG C in aqueous mixture, aqueous mixture 500rpm high-speed stirreds are kept.
Beneficial effect of the present invention is:The medicine addition chlorphenamine maleate of technical solution of the present invention gained treatment eczema
And bagodryl hydrochloride, the effect with antihistaminicum H1 acceptors, Central nervous are with stronger inhibitory action, prevention allergy
Allergy, greatly reduces the allergy rate that medicine is used.Medicine of the present invention also adds the narrow leaved tea tree of assist drug penetration
The fragrant materials such as oil, menthol, camphor, borneol, can help enoxolone, chlorphenamine maleate and Paeonol etc. to import skin
Skin corium, so as to quickly play effect of antipruritic, and alleviates the symptoms such as eczema patients erythema, skin damaged.
Specific embodiment
To describe technology contents of the invention, structural feature, the objects and the effects in detail, below in conjunction with implementation method
It is explained in detail.
The medicine of present invention treatment eczema with the addition of class adrenal hormone and adrenotrophic hormone material enoxolone, pass through
The immunity of eczema patients autologous skin, lifts the mineralocorticoid physiological level of itself secretion of skin, so as to play anti-scabies
The effect itched.Inherently, it is different from the eczema treatment method of external supplement glucocorticoid.
The natural wool fat of medicine addition of the present invention provides a lipid combination for complexity for skin, can imitate and strengthen skin
Original natural lipid combination function in skin.Lanolin can supplement double-layer of lipoid, and strengthen the barrier function of skin.It is wet to prevent
The skin of rash is stimulated by extraneous undesirable element, plays a protective role.Meanwhile, it is capable to repair eczema damaged skin and resist receive
Damage infection of the skin from bacterium and fungi.
The shea butter of medicine addition of the present invention, it is closest with the indices that human sebaceous secrete, rich in unsaturation
Aliphatic acid, strengthen skin performance of keeping humidity, can be damaged eczema skin be moistened, while having promotion damaged part
Reepithelialization.
The Paeonol of medicine addition of the present invention has analgesia, anti-inflammatory, effect that is antipyretic and suppressing allergy.To pressure tail,
The pain physically or chemically caused by factor such as acetic acid, with obvious analgesic activity.To by carrageenan, egg white, formaldehyde, group
The caused inflammatory reaction such as amine, serotonin, bradykinin, dimethylbenzene and endotoxin, with obvious inhibitory action.
The diphenhydramine of medicine addition of the present invention has the effect of antihistaminicum H1 acceptors, and Central nervous have stronger
Inhibitory action, prevents allergy allergy.It is antipruritic, diminish inflammation and play the part of in reducing histamine while acting on eczema healing process
With extremely important effect.
Embodiment 1
1) weigh oil phase component and be heated to 80 DEG C, stir 20min, obtain oil mixture;The oil phase component includes as follows
The raw material of weight portion:1 part of cera alba, 3 parts of C12-15 benzoic ethers, 1 part of nutmeg beans isopropyl propionate, 1 part of titrol, 2
Part stearic acid, 1 part of enoxolone, 1 part of lanolin, 2 parts of shea butters;
Weigh water phase components and be heated to 80 DEG C, stir 20min, obtain aqueous mixture;The water phase components include following weight
Measure the raw material of part:4 parts of glycerine, 1 part of bagodryl hydrochloride, 60 parts of purified waters;
Weigh medicine activity component and be heated to 50 DEG C, stir 20min, obtain aqueous mixture;Pharmaceutical activity mixture;It is described
Medicine activity component includes the raw material of following weight portion:3 portions of chlorphenamine maleates, 5 portions of propane diols, 3 portions of menthols, 3 portions of camphor trees
Brain, 1 part of borneol, 1 part of Paeonol;
2) raw material of following weight part ratio is taken:12 parts of oil mixtures, 65 parts of aqueous mixtures and 16 parts of pharmaceutical activity are mixed
Compound, aqueous mixture is slowly added into by oil mixture at a temperature of 80 DEG C, is kept stirring for 20 minutes;60 DEG C are cooled to, are delayed
Slow to add pharmaceutical activity mixture, medicinal mixture is persistently stirred 20 minutes to obtain in insulation;
3) medicinal mixture is cooled to 35 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 4000rpm,
The matter time is 10 minutes;Take the dish out of the pot the medicine for being aged and must treating eczema.
Embodiment 2
1) weigh oil phase component and be heated to 85 DEG C, stir 25min, obtain oil mixture;The oil phase component includes as follows
The raw material of weight portion:3 parts of cera albas, 4 parts of C12-15 benzoic ethers, 3 parts of nutmeg beans isopropyl propionates, 4 parts of titrols, 2
Part stearic acid, 1 part of enoxolone, 1 part of lanolin, 2 parts of shea butters;
Weigh water phase components and be heated to 85 DEG C, stir 25min, obtain aqueous mixture;The water phase components include following weight
Measure the raw material of part:7 parts of glycerine, 3 parts of bagodryl hydrochlorides, 60 parts of purified waters;
Weigh medicine activity component and be heated to 60 DEG C, stir 25min, obtain aqueous mixture;Pharmaceutical activity mixture;It is described
Medicine activity component includes the raw material of following weight portion:5 portions of chlorphenamine maleates, 5 portions of propane diols, 3 portions of menthols, 3 portions of camphor trees
Brain, 2 parts of borneols, 2 parts of Paeonols;
2) raw material of following weight part ratio is taken:20 parts of oil mixtures, 70 parts of aqueous mixtures and 20 parts of pharmaceutical activity are mixed
Compound, aqueous mixture is slowly added into by oil mixture at a temperature of 85 DEG C, is kept stirring for 30 minutes;65 DEG C are cooled to, are delayed
Slow to add pharmaceutical activity mixture, medicinal mixture is persistently stirred 20-30 minutes to obtain in insulation;
3) cooling water is passed through in water phase phase vessel jacket, is cooled to 35 DEG C, 4000rpm high speed homogenizations 15 minutes, according to
The viscosity of lotion, adjusts the operating time of high speed homogenization, and lotion viscosity is relatively low, continues high speed homogenization, and lotion viscosity reaches
It is filling after being aged 12 hours to after requiring, you can go out container ageing, the medicine of eczema must be treated.
Embodiment 3
1) weigh oil phase component and be heated to 85 DEG C, stir 25min, obtain oil mixture;The oil phase component includes as follows
The raw material of weight portion:3 kilograms of cera albas, 4 kilograms of C12-15 benzoic ethers, 3 kilograms of nutmeg beans isopropyl propionates, 4 kilograms of mutual leaves are white
Thousand layers of oil, 2 kilograms of stearic acid, 1 kilogram of enoxolone, 1 kilogram of lanolin, 2 kilograms of shea butter;
Weigh water phase components and be heated to 85 DEG C, stir 25min, obtain aqueous mixture;The water phase components include following weight
Measure the raw material of part:7 kilograms of glycerine, 3 kilograms of bagodryl hydrochlorides, 60 kilograms of purified waters;
Weigh medicine activity component and be heated to 60 DEG C, stir 25min, obtain aqueous mixture;Pharmaceutical activity mixture;It is described
Medicine activity component includes the raw material of following weight portion:5 kilograms of chlorphenamine maleates, 5 kilograms of propane diols, 3 kilograms of menthols,
3 kilograms of camphors, 2 kilograms of borneols, 2 kilograms of Paeonols;
2) raw material of following weight part ratio is taken:20 kilograms of oil mixtures, 70 kilograms of aqueous mixtures and 20 kilograms of medicines
Active mixture, aqueous mixture is slowly added into by oil mixture at a temperature of 85 DEG C, is kept stirring for 30 minutes;It is cooled to 65
DEG C, pharmaceutical activity mixture is slowly added to, it is incubated, persistently stir 30 minutes to obtain medicinal mixture;
3) cooling water is passed through in water phase phase vessel jacket, is cooled to 35 DEG C, 4000rpm high speed homogenizations 15 minutes, according to
The viscosity of lotion, adjusts the operating time of high speed homogenization, and lotion viscosity is relatively low, continues high speed homogenization, and lotion viscosity reaches
It is filling after being aged 12 hours to after requiring, you can go out container ageing, the medicine of eczema must be treated.
Embodiments of the invention are the foregoing is only, the scope of the claims of the invention is not thereby limited, it is every to utilize this hair
Equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, is included within the scope of the present invention.
Claims (5)
1. a kind of medicine for treating eczema, it is characterised in that the raw material for specifically including following weight portion is mixed:
Oil phase component:1-3 parts of cera alba, 3-5 parts of C12-15 benzoic ethers, 1-3 parts of nutmeg beans isopropyl propionate, 1-4 parts of mutual leaf are white
Thousand layers of oil, 2-5 parts of stearic acid, 0.5-1 parts of enoxolone, 1-3 parts of lanolin, 2-4 parts of shea butter;
Water phase components:4-7 parts of glycerine, 1-3 parts of bagodryl hydrochloride, 60-80 parts of purified water;
Medicine activity component:3-5 parts of chlorphenamine maleate, 5-10 parts of propane diols, 3-5 parts of menthol, 3-5 parts of camphor, 1-3 parts
Borneol, 1-3 part Paeonol.
2. it is according to claim 1 treatment eczema medicine, it is characterised in that the oil phase component, water phase components and medicine
The weight part ratio of thing active component is:20 parts of oil phase components, 70 parts of water phase components, 20 parts of medicine activity components.
3. a kind of preparation method of the medicine for treating eczema, it is characterised in that comprise the following steps:
1) weigh oil phase component and be heated to 80-85 DEG C, stir 20-25min, obtain oil mixture;The oil phase component is included such as
The raw material of lower weight portion:1-3 parts of cera alba, 3-5 parts of C12-15 benzoic ethers, 1-3 parts of nutmeg beans isopropyl propionate, 1-4 parts of mutual leaf
Cajeput oil, 2-5 part stearic acid, 0.5-1 parts of enoxolone, 1-3 parts of lanolin, 2-4 parts of shea butter;
Weigh water phase components and be heated to 80-85 DEG C, stir 20-25min, obtain aqueous mixture;The water phase components include as follows
The raw material of weight portion:4-7 parts of glycerine, 1-3 parts of bagodryl hydrochloride, 60-80 parts of purified water;
Weigh medicine activity component and be heated to 50-60 DEG C, stir 20-25min, obtain aqueous mixture;Pharmaceutical activity mixture;Institute
State raw material of the medicine activity component including following weight portion:3-5 portions of chlorphenamine maleate, 5-10 portions of propane diols, 3-5 portions of peppermint
Brain, 3-5 part camphor, 1-3 parts of borneol, 1-3 parts of Paeonol;
2) raw material of following weight part ratio is taken:12-43 parts of oil mixture, 65-90 parts of aqueous mixture and 16-31 parts of medicine are lived
Property mixture, oil mixture is slowly added into aqueous mixture at a temperature of 80-85 DEG C, is kept stirring for 20-30 minutes;Cooling
To 60-65 DEG C, pharmaceutical activity mixture is slowly added to, be incubated, persistently stir 20-30 minutes to obtain medicinal mixture;
3) medicinal mixture is cooled to 35-40 DEG C, homogeneous is carried out using high speed homogenization device, setting speed is 4000rpm, homogeneous
Time is 10-15 minutes;Take the dish out of the pot the medicine for being aged and must treating eczema.
4. it is according to claim 3 treatment eczema medicine preparation method, it is characterised in that the step 2) in oil phase
The weight part ratio of mixture, aqueous mixture and pharmaceutical activity mixture is:20 parts of oil mixtures, 70 parts of aqueous mixtures,
20 parts of pharmaceutical activity mixtures.
5. the preparation method of the medicine for the treatment of eczema according to claim 3, it is characterised in that the step 2) in by oil
Phase mixture keeps aqueous mixture 500rpm high-speed stirreds when being slowly added into aqueous mixture at a temperature of 80-85 DEG C.
Priority Applications (1)
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CN201611205242.XA CN106692161A (en) | 2016-12-23 | 2016-12-23 | Medicine for treating eczema and preparation method of medicine |
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CN201611205242.XA CN106692161A (en) | 2016-12-23 | 2016-12-23 | Medicine for treating eczema and preparation method of medicine |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109498679A (en) * | 2018-12-27 | 2019-03-22 | 佛山科学技术学院 | A kind of compound Chinese medicinal preparation and preparation method thereof for treating eczema |
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CN101269038A (en) * | 2008-05-16 | 2008-09-24 | 北京正大绿洲医药科技有限公司 | Chlorpheniramine maleate sustained-release dropping pill and preparation method thereof |
CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
CN103169764A (en) * | 2013-03-01 | 2013-06-26 | 福建美菰林生物科技有限公司 | Pharmaceutical composition for treating eczema and preparation method thereof |
CN103520180A (en) * | 2013-09-26 | 2014-01-22 | 长春八一医院 | Medicine composition for treating eczema, seborrheic dermatitis and psoriasis and preparation method thereof |
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2016
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Patent Citations (4)
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CN101269038A (en) * | 2008-05-16 | 2008-09-24 | 北京正大绿洲医药科技有限公司 | Chlorpheniramine maleate sustained-release dropping pill and preparation method thereof |
CN102370861A (en) * | 2011-11-10 | 2012-03-14 | 渤海造船厂集团有限公司 | Emulsifiable paste for treating infantile eczema |
CN103169764A (en) * | 2013-03-01 | 2013-06-26 | 福建美菰林生物科技有限公司 | Pharmaceutical composition for treating eczema and preparation method thereof |
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Application publication date: 20170524 |