WO2021082298A1

WO2021082298A1 - Composition capable of relieving eczema skin condition, and preparation method therefor

Info

Publication number: WO2021082298A1
Application number: PCT/CN2020/074720
Authority: WO
Inventors: 阮静
Original assignee: 深圳市远光宙科技有限公司
Priority date: 2019-10-28
Filing date: 2020-02-11
Publication date: 2021-05-06
Also published as: CN110585318B; CN110585318A; CN113730490B; CN113730490A

Abstract

A composition capable of relieving eczema skin conditions comprising the following raw materials in parts by weight: 1-50 parts of avocado butter, 10-50 parts of coconut oil, 10-50 parts of beeswax, 1-10 parts of Moringa pterygosperma seed oil, 0.01-5 parts of bilberry fruit, 0.01-5 parts of witch hazel leaves, 0.1-5 parts of calendula flower, 0.1-5 parts of licorice, and 0.1-5 parts of vitamin E. The composition can further comprise: 10-50 parts of aloe, 1-10 parts of Sclerocarya birrea seed oil, and 1-40 parts of jojoba seed oil.

Description

Composition capable of relieving skin eczema symptoms and preparation method thereof

Technical field

The present invention relates to the technical field of medicinal skin care, and more specifically, to a composition capable of relieving skin eczema symptoms and a preparation method thereof.

Background technique

Eczema is a severe skin inflammatory reaction caused by a variety of internal and external factors. The histological features are edema between epidermal cells, accompanied by varying degrees of spine hypertrophy and superficial perivascular lymphoid cell infiltration. Due to the edema between skin cells, the intercellular space is enlarged, destroying the original skin barrier, and increasing transdermal water loss; due to the infiltration of inflammatory cells, the normal metabolism of the skin is affected, and the skin becomes dry and desquamated, making the skin more sensitive . In pediatric skin diseases, dermatitis and eczema occupy the first place. The skin lesions of infant eczema are pleomorphic, diffuse and symmetrical. The acute stage is mainly erosion and exudation; the chronic stage is mainly scaly, scab, infiltration and thickening. Eczema in infants and young children is often accompanied by severe itching, which affects appetite and rest, and can be secondary to bacterial infections.

The disadvantage of most current methods and medicines for treating skin eczema symptoms is that they contain hormones, essential oils or spices. Hormonal products will cause different levels of side effects on the skin after use, such as causing hyperadrenal syndrome, increased calcium loss, and affecting the brain and nerve development of infants and young children. In addition, some drugs contain irritating ingredients that can cause symptoms aggravated or other damage. Therefore, there is a need for a skin care product that effectively relieves the symptoms of skin eczema (including infant skin) and does not irritate the skin.

Summary of the invention

The first object of the present invention is to provide a composition for relieving skin eczema symptoms, the composition comprising the following parts by weight of raw materials: 1-50 parts of shea butter, 10-50 parts of coconut oil, and 10-50 parts of beeswax , Wing seed Moringa seed oil 1-10 parts, bilberry fruit 0.01-5 parts, witch hazel leaves 0.01-5 parts, calendula flower 0.1-5 parts, licorice 0.1-5 parts and vitamin E 0.1-5 parts.

In a preferred embodiment of the present invention, the composition includes the following raw materials in parts by weight: 10 to 45 parts by weight of shea butter, 25 to 50 parts of coconut oil, 10 to 30 parts of beeswax, and 1 to winged moringa seed oil. 6 parts, 1 to 5 parts of bilberry fruit, 0.05 to 3 parts of witch hazel leaves, 0.1 to 5 parts of calendula flowers, 1 to 3 parts of licorice, and 1 to 3 parts of vitamin E.

In a preferred embodiment of the present invention, in order to improve the emollient and moisturizing effects of the composition, the composition also includes the following raw materials in parts by weight: 1 to 5 parts of aloe vera, 1 to 10 parts of Burr's hard walnut seed oil, and 1-40 parts of jojoba seed oil.

In a preferred embodiment of the present invention, in order to further improve the sterilization, moisturizing and antipruritic effects, the composition of the present invention includes the following parts by weight of raw materials: 10-20 parts of shea butter, 30-50 parts of coconut oil, 10 parts of beeswax ～30 parts, 1～5 parts of aloe vera, 1～5 parts of Burr's hard walnut seed oil, 1～3 parts of winged moringa seed oil, 10～35 parts of jojoba seed oil, 1～5 parts of bilberry fruit, golden 0.1 to 1 part of hazel leaves, 0.9 to 5 parts of calendula flower, 1-2 parts of licorice and 1-2 parts of vitamin E. More preferably, the composition of the present invention includes the following raw materials in parts by weight: 13-15 parts of shea butter, 30-50 parts of coconut oil, 10-20 parts of beeswax, 1-2 parts of aloe vera, Burr's hard walnut seeds 1 to 2 parts of oil, 1 to 2 parts of winged moringa seed oil, 10 to 35 parts of jojoba seed oil, 1 to 5 parts of bilberry fruit, 0.1 to 1 part of witch hazel leaves, 0.9 to 5 parts of calendula flower , 1 to 2 parts of licorice and 1 to 2 parts of vitamin E.

In a preferred embodiment of the present invention, in order to further improve the effect of treating eczema and alleviating skin itching and redness, the composition of the present invention includes the following raw materials in parts by weight: 25 to 45 parts of shea butter and 30 to 40 parts of coconut oil , Beeswax 10-20 parts, Aloe 1-5 parts, Burr Hard Walnut Seed Oil 1-10 parts, Wing Seed Moringa Seed Oil 1-6 parts, Jojoba Seed Oil 10-20 parts, Bilberry Fruit 1～3 Servings, 0.1 to 2 parts of witch hazel leaves, 0.1 to 2 parts of calendula flowers, 1.5 to 2 parts of licorice, and 1 to 2 parts of vitamin E. More preferably, the composition of the present invention includes the following raw materials in parts by weight: 25 to 45 parts of shea butter, 30 to 32 parts of coconut oil, 10 to 12 parts of beeswax, 1 to 2 parts of aloe vera, Burr's hard walnut seed 1～10 parts of oil, 1～6 parts of wing seed Moringa seed oil, 10～12 parts of jojoba seed oil, 1～2 parts of bilberry fruit, 0.1～2 parts of witch hazel leaves, 0.1～2 parts of calendula flowers , Licorice 1.5-2 parts and Vitamin E 1-2 parts.

In a preferred embodiment of the present invention, the composition for relieving skin eczema symptoms of the present invention is composed of shea butter, coconut oil, beeswax, aloe vera, Burr's hard walnut seed oil, winged moringa seed oil, jojoba seed Composition of oil, bilberry fruit, witch hazel leaves, calendula flower, licorice and vitamins. More preferably, the weight part of the composition of the present invention is 100 parts by weight.

In the present invention, parts by weight can be units of weight known in the art such as μg, mg, g, kg, etc., or multiples thereof, such as 1/10, 1/100, 10 times, 100 times, and the like.

In a preferred embodiment of the present invention, the shea butter is a non-refined or non-processed solid.

In a preferred embodiment of the present invention, coconut oil, Burr's hard walnut seed oil, wing seed moringa seed oil, and jojoba seed oil are all prepared by cold-pressing extraction.

In the present invention, the composition can be made into a conventional skin care product in the field, preferably an external skin care cream. The composition of the present invention is made into an external skin care cream, which is convenient to use and only needs to be applied to the affected area without additional washing.

Another object of the present invention is to provide a method for preparing the above-mentioned composition for relieving skin eczema symptoms, including the following steps:

1) Mix bilberry fruit, witch hazel leaves, marigolds, and licorice with 10-100wt% coconut oil in the original ratio according to the ratio, and extract at 40-60°C for 8-24h to obtain raw material A;

2) Heat the beeswax and the remaining coconut oil in a water bath to 65-70°C and stir evenly to obtain raw material B;

3) During the cooling process of the raw material B, the raw material A and the remaining raw materials are added to it, stirred evenly and then cooled to room temperature.

When the raw materials contain aloe vera, Burr hard walnut seed oil and jojoba seed oil, the jojoba seed oil is heated to 65-70°C in a water bath with beeswax and the remaining coconut oil in step 2), and the raw material B is obtained by stirring uniformly. Aloe vera is added in the form of aloe powder and aloe gel respectively in step 1), and Boer's hard walnut seed oil is added in step 3) with raw material A and other remaining raw materials during the cooling process of raw material B, and the mixture is evenly stirred and then cooled to Room temperature. The weight ratio of aloe powder to aloe gel is 1:10, and the sum of the two masses is the amount of aloe added. That is, step 1) is specifically: mix aloe powder, bilberry fruit, witch hazel leaves, marigold, licorice with the original proportion of 10-100wt% coconut oil according to the ratio, and extract at 40-60℃ for 8-24h , Get raw material A. Step 3) is specifically as follows: in step 3), aloe gel and Burr's hard walnut seed oil are added with raw material A and other remaining raw materials during the cooling process of raw material B, stirred evenly, and cooled to room temperature.

In the present invention, the stirring in the above steps is all carried out in a stainless steel reactor.

Compared with the prior art, the present invention has the following advantages:

1. The invention adopts an all-natural formula, does not contain drugs or hormones, does not contain essential oils and fragrances that are unfavorable to the brain and nerve development of infants and young children, is non-irritating to the skin, and has good safety.

2. In the present invention, calendula flower, bilberry fruit, licorice, beeswax, shea butter, coconut oil, moringa seed oil are added, so it can effectively alleviate the symptoms of eczema.

3. In the present invention, Burr's hard walnut seed oil, jojoba seed oil, and aloe vera are added, so it can achieve the effects of emollient, moisturizing and the like.

4. The coconut oil and vitamin E added in the present invention are natural preservatives, therefore, the existence of contaminating bacteria is avoided.

5. The present invention is convenient to use, only needs to be applied to the body, and does not need to be rinsed off.

6. The product of the present invention is a light yellow paste, which has been subjected to microbiological and hygienic chemical inspections and meets the requirements of "Cosmetics Safety Technical Specifications" (2015 edition).

Detailed ways

The specific implementation of the present invention will be described in further detail below in conjunction with examples. The following examples are used to illustrate the present invention, but not to limit the scope of the present invention.

Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and the raw materials used are all commercially available products.

Example 1

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: shea butter 13%, coconut oil 50%, beeswax 20%, jojoba seed oil 10% %, Aloe Vera 1%, Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 1%, Bilberry Fruit 1%, Witch Hazel Leaf 0.1%, Calendula Flower 0.9%, Licorice 1%, Vitamin E 1 %.

The preparation method of the external skin care cream includes the following steps:

(1) Proportioning and weighing;

(2) Mix 20wt% coconut oil, aloe powder, bilberry fruit, witch hazel leaves, calendula flower and licorice, and extract at 50°C for 8 hours to obtain raw material A;

(3) Heat the beeswax, jojoba seed oil, and the remaining coconut oil in a water bath to 65°C and stir evenly to obtain raw material B;

(4) Take out raw material B from the water bath, add raw material A and shea butter, Burr's hard walnut seed oil, winged moringa seed oil, aloe gum, and vitamin E during the cooling process, stir well and cool down. To room temperature, ready. The weight ratio of the aloe powder added in step (2) to the aloe gel added in step (4) is 1:10, and the sum of the two masses is the added amount of aloe.

The stirring in the above steps (2) to (4) is carried out in a stainless steel reactor.

Example 2

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: 43% shea butter, 30% coconut oil, 10% beeswax, and 10% jojoba seed oil. %, Aloe Vera 1%, Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 1%, Bilberry Fruit 1%, Witch Hazel Leaf 0.1%, Calendula Flower 0.1%, Licorice 1.8%, Vitamin E 1 %.

The preparation method of the external skin care cream of this example is the same as the preparation method of Example 1.

Example 3

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: shea butter 13%, coconut oil 30%, beeswax 10%, and jojoba seed oil 32 %, Aloe Vera 1%, Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 1%, Bilberry Fruit 5%, Witch Hazel Leaf 1%, Calendula Flower 5%, Licorice 1%, Vitamin E 1 %.

Example 4

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: 25% shea butter, 30% coconut oil, 10% beeswax, and 10% jojoba seed oil. %, Aloe Vera 1%, Burr Hard Walnut Seed Oil 10%, Wing Seed Moringa Seed Oil 5%, Bilberry Fruit 1%, Witch Hazel Leaf 2%, Calendula Flower 2%, Licorice 1.8%, Vitamin E 1 %.

Example 5

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: avocado tree fruit fat 20%, coconut oil 40%, beeswax 20%, jojoba seed oil 10 %, Aloe Vera 2%, Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 3%, Bilberry Fruit 1%, Witch Hazel Leaf 0.1%, Calendula Flower 0.9%, Licorice 1%, Vitamin E 1 %.

Example 6

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: avocado tree fruit fat 20%, coconut oil 30%, beeswax 10%, and jojoba seed oil 25 %, Aloe Vera 5%, Burr Hard Walnut Seed Oil 5%, Wing Seed Moringa Seed Oil 1%, Bilberry Fruit 1%, Witch Hazel Leaf 0.1%, Calendula Flower 0.9%, Licorice 1%, Vitamin E 1 %.

Example 7

This embodiment provides an external skin care cream for relieving skin eczema. The external skin care cream is composed of the following mass percentages of raw materials: 30% shea butter, 40% coconut oil, 10% beeswax, and 10% jojoba seed oil. %, Aloe Vera 2%, Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 1%, Bilberry Fruit 1%, Witch Hazel Leaf 0.9%, Calendula Flower 0.1%, Licorice 2%, Vitamin E 2 %.

Comparative example 1

This comparative example provides an external skin care cream, which is composed of the following mass percentages of raw materials: shea butter 13%, coconut oil 50%, beeswax 20%, jojoba seed oil 10%, and aloe 1% , Burr Hard Walnut Seed Oil 1%, Wing Seed Moringa Seed Oil 1%, Chamomile 1%, Witch Hazel Leaf 0.1%, Honeysuckle 0.9%, Forsythia 1%, Vitamin E 1%.

Experimental example

1. The external skin care creams obtained in the examples are all light yellow creams, which have been subjected to microbiological inspection (see Table 1) and hygienic chemical inspection (see Table 2) to meet the requirements of "Cosmetics Safety Technical Specifications" (2015 edition).

Table 1 Microbiological test results

Table 2 Hygienic Chemistry Inspection Results

2. The effect results of the external skin care creams of the examples

(1) The effect of the product of the present invention on reducing skin irritation symptoms:

In China and the United States, volunteers aged between 9 and 65 were randomly selected, 42 people were randomly selected from each group, and the products of the examples and comparative examples were applied to the volunteers’ skins, and the effects of the products were investigated through questionnaires. . The reaction of these volunteers to skin irritation to the product is shown in Table 3.

table 3

(2) Test the anti-itch effect of the product of the present invention on the skin:

In China and the United States, randomly selected volunteers aged between 9 and 65 years old with itchy skin, each group randomly selected 38 people, and during the onset of symptoms, the products of the examples and comparative examples were applied to the volunteers’ affected areas , Through the questionnaire method, investigate the reaction within 1 hour and investigate the product effect. The reaction of these volunteers to skin irritation and antipruritic reaction to the product is shown in Table 4.

Table 4

(3) Test the effect of the product of the present invention on eliminating skin redness and swelling:

In China and the United States, randomly selected volunteers aged between 6 months and 65 years old with skin redness and eczema. 28 people in each group were randomly selected. During the onset of symptoms, the products of the Examples and Comparative Examples were applied to Volunteers used a questionnaire to investigate the effect of the product on the skin of the volunteers twice a day in the morning and evening, a course of 7 days. The reaction of these volunteers to the product to eliminate redness and swelling is shown in Table 5.

table 5

Finally, the method of the present invention is only a preferred embodiment and is not used to limit the protection scope of the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

A composition for relieving skin eczema symptoms, characterized in that it comprises the following parts by weight of raw materials: 1-50 parts of shea butter, 10-50 parts of coconut oil, 10-50 parts of beeswax, and moringa seed oil 1-10 parts, bilberry fruit 0.01-5 parts, witch hazel leaves 0.01-5 parts, calendula flower 0.1-5 parts, licorice 0.1-5 parts, and vitamin E 0.1-5 parts.
The composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight: 10 to 45 parts by weight of shea butter, 25 to 50 parts of coconut oil, 10 to 30 parts of beeswax, and winged moringa seed oil 1 ~6 parts, 1~5 parts of bilberry fruit, 0.05~3 parts of witch hazel leaves, 0.1~5 parts of calendula flowers, 1~3 parts of licorice and 1~3 parts of vitamin E.
The composition according to claim 1, further comprising the following raw materials in parts by weight: 1 to 5 parts by weight of aloe vera, 1 to 10 parts of Burr's hard walnut seed oil, and 1 to 40 parts of jojoba seed oil.
The composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight: 10-20 parts by weight of shea butter, 30-50 parts of coconut oil, 10-30 parts of beeswax, 1-5 parts of aloe vera, 1 to 5 parts of hard walnut seed oil, 1 to 3 parts of wing seed moringa seed oil, 10 to 35 parts of jojoba seed oil, 1 to 5 parts of bilberry fruit, 0.1 to 1 part of witch hazel leaves, calendula flower 0.9 to 5 parts, 1 to 2 parts of licorice, and 1 to 2 parts of vitamin E.
The composition according to claim 1, characterized in that it comprises the following raw materials in parts by weight: 25 to 45 parts of shea butter, 30 to 40 parts of coconut oil, 10 to 20 parts of beeswax, 1 to 5 parts of aloe vera, 1～10 parts of hard walnut seed oil, 1～6 parts of wing seed moringa seed oil, 10～20 parts of jojoba seed oil, 1～3 parts of bilberry fruit, 0.1～2 parts of witch hazel leaves, calendula flower 0.1 to 2 servings, 1.5 to 2 servings of licorice, and 1 to 2 servings of vitamin E.
The composition of claim 1, wherein the shea butter is a non-refined or non-processed solid.
The composition according to any one of claims 3 to 5, wherein the coconut oil, Burr's hard walnut seed oil, wing seed moringa seed oil, and jojoba seed oil are all prepared by cold pressing Got.
The composition according to any one of claims 1 to 7, wherein the composition is an external skin care cream.
The preparation method of the composition according to any one of claims 1 to 8, characterized in that it comprises the following steps:

1) Mix bilberry fruit, witch hazel leaves, marigold, licorice with 10-100wt% coconut oil and aloe powder in the original ratio according to the ratio, and extract at 40-60℃ for 8-24h to obtain raw material A;

2) Heat the beeswax and the remaining coconut oil in a water bath to 65-70°C and stir evenly to obtain raw material B;

3) During the cooling process of the raw material B, the raw material A and the remaining raw materials are added to it, stirred evenly and then cooled to room temperature.
The preparation method according to claim 9, characterized in that step 2) further comprises heating the jojoba seed oil, beeswax and the remaining coconut oil in a water bath to 65-70°C; step 3) also comprises cooling the raw material B Burr hard walnut seed oil is added during the process; aloe vera is added to step 1) and step 3) in the form of aloe powder and aloe gel.