CN109431943B - Repairing paste for infantile eczema and preparation thereof - Google Patents
Repairing paste for infantile eczema and preparation thereof Download PDFInfo
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- CN109431943B CN109431943B CN201811594143.4A CN201811594143A CN109431943B CN 109431943 B CN109431943 B CN 109431943B CN 201811594143 A CN201811594143 A CN 201811594143A CN 109431943 B CN109431943 B CN 109431943B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention relates to a repair cream for infantile eczema, which mainly comprises the following components in percentage by weight: 0.5-5% of holy basil extract, 0.5-6% of rough oat seed extract, 1-5% of fructus ardisiae reversing extract, 1-7% of ribes nigrum extract, 0.1-2% of cynara scolymus oil, 0.2-4% of moringa seed oil, 3-8% of echinacea purpurea extract, 1-6% of egg oil, 5-25% of emollient, 3-10% of humectant, 0.02-0.5% of antioxidant, 0.05-0.3% of anti-allergy agent, 0.6-1.2% of thickening agent, 1.5-3.5% of emulsifier, 0.1-5% of co-emulsifier, 0.25-1% of preservative and 100% of deionized water. The components of the repair cream provided by the invention have synergistic effects, so that the repair cream can maintain skin moisture and moisten skin, can provide a solution for preventing, treating and repairing skin inflammations such as eczema from three dimensions, can effectively remove the skin inflammations such as eczema, does not contain antibiotics and hormones, has no toxic or side effect, has no stimulation to skin, can be used as a skin care product directly contacting with the skin, and is particularly suitable for infants.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a repairing cream for infantile eczema.
Background
Infantile eczema (infantile eczema), which is called as infantile eczema or fetal wound healing sore in traditional Chinese medicine, is allergic dermatitis caused by various internal and external factors and is one of the most common skin diseases in the infant period. Skin lesions are polymorphic lesions mainly caused by herpes simplex, tend to exude, have repeated outbreaks, alternate between acute and chronic periods, are accompanied by severe pruritus, and have difficult-to-determine etiology. The disease has no obvious seasonal nature, but the disease is easy to relapse in winter, can be generalized or limited, and the disease is on the epidermis, so no scar is generally left after healing, and the common symptoms comprise diaper rash, saliva rash, contact dermatitis, red buttocks and the like.
The skin of infants is characterized in that the horny layer is much thinner than that of adults, the skin is delicate and tender, and the skin has strong reaction to allergic substances and toxic substances; the water content is high due to the lack of a cortical membrane, but the water loss is fast, and the moisture needs to be kept moist and locked. Eczema in infants is a common skin inflammation problem. However, the ointment with good treatment effect on eczema in the market at present generally contains hormone, dependence appears after the ointment is used, the eczema easily recurs once the ointment is stopped, the skin immunity of infants is poor, and the eczema ointment is not easily accepted by families of patients. Therefore, the development of the infant skin care product which is safe and effective, takes effect quickly, has no hormone, has no side effect, can treat eczema and can achieve the aim of caring the skin of the infant is an urgent problem to be solved.
Disclosure of Invention
The invention aims to provide a repairing paste for infantile eczema, which is used for solving the problems in the prior art and the like.
The repairing paste for the infantile eczema mainly comprises the following components in percentage by weight:
further, the mass ratio of the holy basil extract, the Avena sativa seed extract, the ardisia japonica extract, the ribes nigrum extract, the Echium oil, the moringa seed oil, the echinacea purpurea extract and the egg oil is 1: 3: 2: 3: 0.5: 1: 5: 5.
further, the total amount of the holy basil extract, the Avena sativa seed extract, the Elsholtzia bodinieri extract, the ribes nigrum extract, the Echium oil, the moringa seed oil and the echinacea purpurea extract is 8-25%.
Further, the emollient is at least one of polydimethylsiloxane, caprylic/capric triglyceride, petrolatum, and jojoba seed oil.
Further, the antioxidant is tocopherol; the anti-allergic agent is allantoin.
Further, the thickening agent is at least one of xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate copolymer.
Further, the emulsifier is cetearyl glucoside; the auxiliary emulsifier is cetostearyl alcohol and sodium stearyl glutamate. The preservative is at least one of p-hydroxyacetophenone, caprylyl hydroximic acid and 1, 2-hexanediol.
Further, the humectant is at least one of a mixture of propylene glycol and glycerin.
The preparation of the repair cream for infantile eczema mainly comprises the following steps:
(1) sequentially adding deionized water, a humectant, an emulsifier, an auxiliary emulsifier and an anti-allergy agent into an emulsifying pot, stirring and heating to 80-85 ℃, and preserving heat for 20 minutes for later use to obtain a phase A component mixture;
(2) sequentially adding an emollient, egg yolk oil and a thickening agent into an oil phase pot, stirring and heating to 80-85 ℃, and keeping the temperature for later use to obtain a phase B component mixture;
(3) adding the phase B component mixture into the phase A component mixture under a vacuum condition, mixing, homogenizing and emulsifying, keeping the temperature for 30 minutes, and cooling to 45 ℃ under stirring to obtain a total mixture;
(4) adding holy basil extract, Avena sativa seed extract, Elsholtzia bodinieri extract, ribes nigrum extract, Echium oil, Moringa seed oil, Echinacea purpurea extract, antiseptic and antioxidant into the total mixture in step (3), stirring, mixing, cooling to about 30 deg.C, and discharging;
(5) and standing for 24 hours.
The holy basil extract contains high-concentration optimized active substances with strong anti-inflammatory and skin-soothing components, such as ursolic acid, rosmarinic acid and other triterpenoids, and has good anti-inflammatory and soothing functions.
The Avena sativa Linne seed extract contains 20-30 different polyphenols, and the avenanthramide has strong antioxidant effect, and also has antiinflammatory and antipruritic effects.
The egg yolk oil contains abundant vitamins A, D and lecithin, has important effect on regeneration and metabolism of human skin, promotes skin wound to heal early, and has effects of moistening skin and repairing chapped skin; ben Cao gang mu (compendium of materia Medica) says that egg is fried to obtain oil and is applied to head sore, and egg yolk oil can be used for treating skin problems such as eczema, psoriasis, tinea pedis, tinea capitis and the like.
The beta-sitosterol contained in the ardisia japonica extract can effectively inhibit skin irritation and anaphylactic reaction, and has the effects of relieving and protecting inflamed skin.
The ribes nigrum extract mainly contains prodelphinidins (such as delphinidin, delphinidin and isodelphinidin), acts on Cyclooxygenase (COX), is a cyclooxygenase inhibitor, has remarkable anti-inflammatory activity, and has good inflammation control effect.
The Echium oil is rich in omega 3 and omega 6 oleate, and can promote cell regeneration, act on inflammation, recover cell membrane fluidity, and make intercellular exchange smoother.
The moringa seed oil is rich in polyphenols (quercetin, kaempferol, chlorogenic acid and the like) and flavonoids, and has the effects of resisting bacteria, resisting inflammation and the like.
The echinacea purpurea extract is used as a traditional anti-inflammatory drug in North America and Europe, and has a remarkable anti-inflammatory effect. The polyphenol, polysaccharide and isobutylthalimide of echinacea purpurea all show anti-inflammatory activity in vitro or in vivo models. The mechanism is to inhibit hyaluronidase, reduce infiltration of inflammatory cells, inhibit cyclooxygenase, block synthesis of prostaglandin and have certain inhibition effect on swelling and exudation caused by acute inflammation. Modern pharmacological studies have also demonstrated that it can prevent pathogen invasion, and caffeic acid derivatives can inhibit hyaluronidase, and maintain the structure and integrity of connective tissue and its intercellular matrix. The polysaccharide can inhibit edema and reduce inflammatory cell infiltration. Alkylamides inhibit cyclooxygenase, block prostaglandin synthesis, and have properties of relieving pain, fever and inflammation.
Compared with the prior art, the plant active ingredients of the invention, namely, the holy basil extract, the Avena sativa seed extract, the ardisia japonica extract, the ribes nigrum extract, the echium oil, the moringa seed oil and the echinacea purpurea extract, can generate a synergistic interaction effect, and treat and repair the symptoms of eczema, such as redness, swelling, itching and the like from the aspects of antibiosis, inflammation diminishing and antioxidation; egg yolk oil is added to quickly repair the skin of the infant, strengthen the physical barrier of the skin of the infant and enhance the capability of the skin to resist external stimulation; the skin-care lotion is matched with the emollient of the whole system to have obvious treatment effect on the eczema, can immediately relieve various discomforts caused by the eczema of the infants after long-term use, and can simultaneously enhance the skin to resist external stress and influence, repair the damaged skin and prevent the generation of the eczema. The repair cream for infantile eczema can maintain skin moisture and moisten skin, can provide a solution for treating, preventing and repairing three dimensions of eczema and other skin inflammations, effectively removes the eczema and other skin inflammations, does not contain antibiotics and hormones, has no toxic or side effect, has no stimulation to skin, can be used as a skin care product directly contacting with the skin, and is particularly suitable for infants.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below.
A repairing cream for infantile eczema comprises the components in percentage by weight as shown in table 1.
Table 1 table of raw material components of a repairing cream for infantile eczema
The manufacturing process comprises the following steps:
(1) sequentially adding the phase A components into an emulsifying pot, stirring, heating to 80-85 ℃, and keeping the temperature for 20 minutes for later use to obtain a phase A component mixture;
(2) sequentially adding the phase B components into an oil phase pot, stirring, heating to 80-85 ℃, and keeping the temperature for later use to obtain a phase B component mixture;
(3) adding the phase B component mixture into the phase A component mixture under a vacuum condition, mixing, homogenizing and emulsifying, keeping the temperature for 30 minutes, and cooling to 45 ℃ under stirring to obtain a total mixture;
(4) adding the phase C component into the total mixture, stirring and mixing, cooling to about 30 ℃, and discharging for later use;
(5) and standing for 24 hours.
Sample 10
The mass ratio of holy basil extract, Avena sativa seed extract, Elsholtzia bodinieri extract, ribes nigrum extract, Echium oil, Moringa seed oil, Echinacea purpurea extract and egg oil of sample 9 was changed to 1: 1: 1: 1: 1: 1: 1: 1, the total content was unchanged, the other components and their contents were unchanged, and the preparation method was the same as sample 10.
Sample 11
The mass ratio of the holy basil extract, the Avena sativa seed extract, the Elsholtzia bodinieri extract, the ribes nigrum extract, the Echium oil, the moringa seed oil, the echinacea purpurea extract and the egg oil of the sample 9 is changed to 1: 1: 1: 1: 1: 1: 5: 5, the total content is unchanged, other components and the content thereof are unchanged, and the preparation method is the same.
Sample 12
The mass ratio of the holy basil extract, the Avena sativa seed extract, the Elsholtzia bodinieri extract, the ribes nigrum extract, the Echium oil, the Moringa seed oil and the Echinacea purpurea extract of the sample 9 is changed to 1: 1: 1: 1: 1: 1: 1, the total content is unchanged, the content of egg yolk oil is unchanged, other components and the content thereof are unchanged, and the preparation method is the same.
Sample 13
The mass ratio of holy basil extract, oat seed extract of brown hair, fructus ardisiae coicis extract, ribes nigrum extract, echium oil, moringa seed oil and echinacea purpurea extract of sample 9 is still 1: 3: 2: 3: 0.5: 1: 5, the total content is 8 percent, the content of the egg yolk oil is not changed, the content of the deionized water is adjusted to 100 percent, other components and the content thereof are not changed, and the preparation method is the same.
Sample 14
The mass ratio of holy basil extract, oat seed extract of brown hair, fructus ardisiae coicis extract, ribes nigrum extract, echium oil, moringa seed oil and echinacea purpurea extract of sample 9 is still 1: 3: 2: 3: 0.5: 1: 5, the total content is 25 percent, the egg yolk oil content is not changed, the deionized water content is adjusted to 100 percent, other components and the contents thereof are not changed, and the preparation method is the same.
Data analysis
1. Eczema was treated 420 cases by applying the cream for infant eczema of preparation example 1. 210 male and 210 female, wherein the age is 3 years at most, the minimum is 20 days after birth, the disease course is 2 months to 1 year at most, the shortest is 2 weeks at most, the disease part is diseased, 300 head and face parts are treated, and 120 other parts are treated. The treatment cream for infantile eczema was randomly divided into 14 groups, each of which was 30 (male and female 15) and used for samples 1-14, respectively, and the treatment effect was counted once in the morning and once in the evening after one week, and the recurrence of eczema was counted after three months of persistent use, and the curative effect analysis is shown in table 1 below.
Table 1 sample 1-sample 14 curative effect analysis of a repair cream for infantile eczema
The table shows that the combination of the plant active ingredients has synergistic effect, thereby effectively and effectively treating infantile eczema and preventing eczema.
2. Counting scoring trial data: 280 test subjects with eczema infants at 2.5-3 years old are randomly divided into 14 groups of 20 patients, and the test method comprises the following steps: the test subjects applied the cream for infant eczema of samples 1-14, respectively, once in the morning and at night, and the test subjects and mothers observed the effect every day. Two weeks later the trial effect was reviewed in the form of a questionnaire to allow the mother in the trial period to score the effect of the sample, 10 points being full and averaged as shown in table 2.
Table 2 sample 1-sample 14. test effectiveness scores for repair creams against infantile eczema
| Relieving and itching-relieving effect | Red fading effect | Detumescence effect | Repairing effects | Moistening and moisturizing effectFruit | |
| Sample 1 | 5.5 | 7.2 | 7.9 | 8.1 | 7.6 |
| Sample 2 | 7.0 | 7.3 | 7.7 | 8.3 | 7.2 |
| Sample 3 | 7.2 | 7.2 | 5.6 | 8.0 | 7.5 |
| Sample No. 4 | 7.5 | 6.9 | 7.2 | 5.0 | 6.8 |
| Sample No. 5 | 6.0 | 7.0 | 7.8 | 8.0 | 7.5 |
| Sample No. 6 | 7.2 | 7.0 | 7.6 | 7.8 | 7.4 |
| Sample 7 | 7.3 | 6.9 | 7.6 | 5.5 | 7.0 |
| Sample 8 | 7.1 | 6.7 | 7.0 | 7.7 | 7.5 |
| Sample 9 | 8.8 | 9.0 | 8.9 | 9.3 | 8.1 |
| Sample 10 | 7.2 | 7.0 | 7.1 | 7.2 | 7.7 |
| Sample 11 | 7.5 | 7.0 | 7.2 | 7.6 | 7.8 |
| Sample 12 | 7.5 | 7.1 | 7.2 | 8.3 | 7.9 |
| Sample 13 | 8.2 | 8.6 | 8.2 | 8.8 | 8.0 |
| Sample 14 | 8.3 | 8.5 | 8.3 | 8.9 | 7.9 |
And (4) test conclusion: the results show that the plant active ingredients used in the invention are matched and have a synergistic effect, so that the plant active ingredients have good effects of relieving, eliminating redness and diminishing swelling, and also have good effects of moistening and preserving moisture.
It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.
Claims (9)
1. The repairing paste for the infantile eczema is characterized by mainly comprising the following components in percentage by weight:
the extract of Ocimum sanctum is 0.5-5%
Herba Avenae Fatuae seed extract 0.5-6%
1-5% of extract of herba Ardisiae Bicoloris
Ribes nigrum extract 1-7%
Echium oil 0.1-2%
0.2 to 4 percent of moringa seed oil
3-8% of echinacea purpurea extract
Egg oil 1-6%
Emollient 5-20%
Humectant 3-10%
0.02-0.5% of antioxidant
0.05-0.3% of anti-allergy agent
0.6 to 1.2 percent of thickening agent
Emulsifier 1.5-3.5%
0.1 to 5 percent of auxiliary emulsifier
0.25 to 1 percent of preservative
Deionized water to 100%;
the anti-allergic agent is allantoin.
2. The repair cream for infantile eczema according to claim 1, wherein the mass ratio of holy basil extract, Avena sativa seed extract, Elsholtzia bodinieri extract, ribes nigrum extract, Echium oil, Moringa oleifera seed oil, Echinacea purpurea extract and egg oil is 1: 3: 2: 3: 0.5: 1: 5: 5.
3. the repair cream for infantile eczema as claimed in claim 1, wherein the total amount of holy basil extract, Avena sativa seed extract, Elsholtzia bodinieri extract, ribes nigrum extract, Echium oil, Moringa seed oil, and Echinacea purpurea extract is 8-25%.
4. The repair cream for infantile eczema according to claim 1, wherein the emollient is at least one of polydimethylsiloxane, caprylic/capric triglyceride, petrolatum, jojoba seed oil.
5. The repair cream for infantile eczema according to claim 1, wherein the antioxidant is tocopherol.
6. The repair cream for infantile eczema as claimed in claim 1, wherein the thickener is at least one of xanthan gum and sodium acrylate/sodium acryloyldimethyl taurate copolymer.
7. The repair cream for infantile eczema according to claim 1, characterized in that the emulsifier is cetearyl glucoside; the auxiliary emulsifier is cetostearyl alcohol and sodium stearyl glutamate.
8. The repair cream for infantile eczema as claimed in claim 1, wherein said humectant is a mixture of propylene glycol and glycerin.
9. The preparation method of the repair cream for infantile eczema as claimed in claim 1, which is characterized by mainly comprising the following steps:
(1) sequentially adding deionized water, a humectant, an emulsifier, an auxiliary emulsifier and an anti-allergy agent into an emulsifying pot, stirring and heating to 80-85 ℃, and preserving heat for 20 minutes for later use to obtain a phase A component mixture;
(2) sequentially adding an emollient, egg yolk oil and a thickening agent into an oil phase pot, stirring and heating to 80-85 ℃, and keeping the temperature for later use to obtain a phase B component mixture;
(3) adding the phase B component mixture into the phase A component mixture under a vacuum condition, mixing, homogenizing and emulsifying, keeping the temperature for 30 minutes, and cooling to 45 ℃ under stirring to obtain a total mixture;
(4) adding holy basil extract, Avena sativa seed extract, Elsholtzia bodinieri extract, ribes nigrum extract, Echium oil, Moringa seed oil, Echinacea purpurea extract, antiseptic, and antioxidant into the total mixture in step (3), stirring, mixing, cooling to 30 deg.C, and discharging;
(5) and standing for 24 hours.
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| CN109758399B (en) * | 2019-03-22 | 2021-11-30 | 广东润洁日化有限公司 | Repair paste for red buttocks of infants |
| CN110279602A (en) * | 2019-07-12 | 2019-09-27 | 上海美浮特生物科技有限公司 | Skin repair composition, preparation method, and the application in cosmetics |
| CN115671013B (en) * | 2022-10-13 | 2023-05-16 | 广州普伽娜生物科技有限公司 | Whitening cream and preparation method thereof |
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