CN110812295B - Infantile tinea-repairing cream - Google Patents

Abstract

The invention discloses an infant infantile eczema repair cream which comprises camellia seed oil, argania spinosa kernel oil, safflower seed oil, bisabolol, vitamin E, paeonol, clove oil, mandarin orange peel extract and mother chrysanthemum oil. The infant infantile eczema repair cream disclosed by the invention is added with multiple natural components, can achieve the drug effect similar to that of a hormone ointment, can be used for a long time, is light and moist in skin feel, and can effectively care delicate skin of an infant.

Description

Infantile tinea-repairing cream

Technical Field

The invention relates to the technical field of daily chemical products, and in particular relates to infant infantile eczema repair cream.

Background

Infantile eczema, called infantile eczema in traditional Chinese medicine, is a common skin disease of infants and is frequently seen in infants born at 40d-2 years old. The causes of infantile eczema are very complex, including internal and external factors. Internal causes are mainly associated with the skin characteristics and allergic constitution of infants. In this period, the stratum corneum of the skin of children is thin, the capillary network is rich, the endothelium contains more water and chloride, and is sensitive to various stimulation factors, so that allergic reactions are easy to occur. The main external factors causing eczema are mechanical friction and stimulation of saliva and milk liquid when the sensitized foods such as fish, shrimp, beef and mutton, milk, eggs and the like are eaten, and some parents take a bath for the infant with soap with strong alkalinity and can also cause the eczema. In addition, physical factors such as sunlight, ultraviolet rays, cold, damp heat, etc., exposure to silk or rayon, and skin uncleanness, etc., may induce eczema or aggravate the condition. Some children may have bronchial asthma or allergic rhinitis and other allergic diseases during or after eczema, which are closely related to the hereditary allergic constitution.

The existing treatment of infantile eczema generally adopts an oral and external prevention and treatment method, because the medicine for infants is not easy to select, the clinical external medicine often contains glucocorticoid medicines or histamine antiallergic medicines, but has more side effects, easily causes systemic or local adverse reactions, and can also cause drug-dependent dermatitis if the external hormone preparation is used for a long time or in a short time in a large dose. For example, doctors usually select vitamin C, dexamethasone and some clinical medicines to combine, but the treatment days cannot be too long, the disease condition is easy to aggravate, the disease condition is changed from local to systemic, and if the medicines are continuously taken, the patient has glucocorticoid dependence. Because of the characteristic of repeatability of skin allergic diseases such as infantile eczema and the like, the glucocorticoid ointment mainly used for treating the skin diseases at present has side effects and cannot be used for a long time, and other traditional Chinese medicine ointments are mostly ointments, are thick and heavy in skin feel, and cannot be used for exudative affected parts.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provide the infantile eczema repair cream.

In order to achieve the purpose, the invention adopts the technical scheme that: an infant infantile tinea manuum repair cream comprises camellia seed oil, argania spinosa kernel oil, safflower seed oil, bisabolol, vitamin E, paeonol, clove oil, mandarin orange peel extract and chamomile oil.

Camellia JAPONICA (Camellia JAPONICA) seed oil has anti-inflammatory, antioxidant, and skin barrier strengthening and repairing effects. Aralia SPINOSA (Argania SPINOSA) kernel oil contains 80% unsaturated fatty acids, is rich in essential fatty acids, is more resistant to oxidation than olive oil, and also contains a large amount of fatty acids, sterols, vitamin E and phenolic compounds. The skin moisturizing cream comprises a large amount of essential fatty acid, unsaturated fatty acid and linoleic acid, and the linoleic acid has obvious effects on resisting inflammation, reducing acne and moisturizing when being applied to the skin.

The safflower seed oil contains linoleic acid, has the anti-inflammatory effect, does not block pores, and is more suitable for sensitive skin. The safflower seed oil, the bisabolol and the vitamin E have the effects of inhibiting bacteria, promoting wound healing and resisting inflammation. Paeonol can inhibit the generation of superoxide anion free radical in cell, and has antiinflammatory, repercussive, analgesic, and antiallergic effects. Flos Caryophylli (SYZYGIUM AROMATICUM) oil has repercussive, antiinflammatory and antiallergic effects. The pericarp extract of mandarin orange (Citrus UNSHIU) has effects in inhibiting histamine release in mast cell, strengthening skin barrier, and inhibiting the induction of eczema. The flos Matricariae Chamomillae oil has antiallergic effect.

The infant infantile eczema repair cream disclosed by the invention is added with the multiple natural components, can achieve the drug effect similar to that of a hormone ointment, can be used for a long time, is light and moist in skin feel, and can effectively care delicate skin of an infant.

Preferably, the infant infantile eczema repair cream comprises the following components in parts by weight: 6-10 parts of camellia seed oil, 4-8 parts of argania spinosa kernel oil, 0.4-1.62 parts of safflower seed oil, 0.085-0.34 part of bisabolol, 0.01-0.04 part of vitamin E, 0.1-1 part of paeonol, 0.1-0.6 part of clove oil, 1-3 parts of mandarin orange peel extract and 0.05-0.2 part of chamomile oil. The components in the proportion can better realize the effect of relieving the infantile milk moss. More preferably, the infant infantile eczema repair cream comprises the following components in parts by weight: 8 parts of camellia seed oil, 6 parts of argania spinosa kernel oil, 0.81 part of safflower seed oil, 0.17 part of bisabolol, 0.02 part of vitamin E, 0.5 part of paeonol, 0.3 part of clove oil, 2 parts of mandarin orange peel extract and 0.1 part of mother chrysanthemum oil.

Preferably, the infant milk moss repair cream further comprises 0.05-0.2 parts of a mixture of canola oil and rosemary leaf extract. Rosmarinus OFFICINALIS (Rosmarinus OFFICINALIS) leaf extract is a preferred antioxidant, astringent and anti-inflammatory agent. The addition of the canola oil and the rosemary leaf extract can soften and moisten skin and play the roles of anti-inflammation and astringency.

Preferably, the infant milk moss repair cream further comprises 0.01-0.04 parts by weight of camellia extract. The Camellia JAPONICA (Camellia JAPONICA) flower extract has good antioxidant and antiinflammatory effects, and can be added into repair cream for enhancing repair effect.

Preferably, the infant milk moss repair cream further comprises 1-3 parts by weight of an anti-allergy agent, wherein the anti-allergy agent is a mixture of shea butter, chamomile leaf extract, glycyrrhiza glabra root extract, centella asiatica extract, rosemary leaf extract, vitamin E, scutellaria baicalensis root extract, tea leaf extract and polygonum cuspidatum root extract. The anti-allergy agent has the effects of anti-allergy, anti-inflammation, antioxidation, relieving repair and anti-allergy, and can effectively relieve the sphagnum lactum when added into repair cream.

Preferably, the infant milk moss repair cream further comprises 0.1-0.3 part by weight of natural borneol, 0.05-0.2 part by weight of o-cymene-5-alcohol and 0.1-0.3 part by weight of allantoin. The natural borneol has the functions of resisting inflammation, reducing swelling, promoting blood circulation to remove blood stasis, particularly promoting the absorption of active ingredients, and has strong antibacterial and analgesic effects, and can promote wound healing. The repair cream is also added with the anti-inflammatory component, so that the using effect of the repair cream can be further improved.

Preferably, the infant milk moss repair cream further comprises the following components in parts by weight: 4-8 parts of glycerol, 1-3 parts of phytosterol oleate, 0.05-0.2 part of tocopheryl acetate, 0.01-0.05 part of sodium hyaluronate, 0.5-2 parts of erythritol and 3-7 parts of saccharide isomer. The phytosterol ester is fat-soluble phytosterol ester, has melting point close to body temperature, and can be used as natural substitute of vaseline or lanolin to increase skin hydration degree and improve skin barrier function. The infant milk moss repair cream is further added with the moisturizing component and the anti-inflammatory component, so that the repair cream has the effect of moisturizing from inside to outside, and a skin barrier can be formed on the surface of skin after the repair cream is used to moisten the skin.

Preferably, the infant milk moss repair cream further comprises the following components in parts by weight: 0.1-1 part of hydrogenated lecithin, 0.1-0.5 part of potassium cetyl phosphate, 0.5-3 parts of cetearyl alcohol, 0.5-1.5 parts of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.01-0.03 part of disodium EDTA, 1-3 parts of polydimethylsiloxane and 0.5-2 parts of a mixture of polydimethylsiloxane and dimethiconol.

Preferably, the infant milk moss repair cream further comprises the following components in parts by weight based on 100 parts by weight in total: 8 parts of camellia seed oil, 6 parts of argania spinosa kernel oil, 1 part of a mixture of safflower seed oil, bisabolol and vitamin E, 0.5 part of paeonol, 0.3 part of clove oil, 2 parts of mandarin orange peel extract, 0.1 part of chamomile oil, 0.1 part of a mixture of canola oil and rosemary leaf extract, 1, 3-propylene glycol, 1 part of a mixture of water and camellia extract, 2 parts of an anti-sensitizer, 0.2 part of natural borneol, 6 parts of glycerol, 2 parts of phytosterol oleate, 0.1 part of o-cymene-5-ol, 0.1 part of tocopherol acetate, 0.03 part of sodium hyaluronate, 1 part of erythritol, 0.2 part of allantoin, 5 parts of saccharide isomerate, 0.5 part of hydrogenated lecithin, 0.3 part of potassium cetyl phosphate, 1.5 part of cetylstearyl alcohol, 1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.02 part of EDTA disodium, 2 parts of polydimethylsiloxane, 2 parts of polydimethysiloxane, 1 part of mixture of polydimethylsiloxane and dimethiconol, 0.4 part of mixture of caprylic hydroxamic acid, caprylic glycerol and propylene glycol, 0.2 part of p-hydroxyacetophenone and the balance of water. The repair cream adopting the formula can repair damaged barriers, has the effects of resisting inflammation and bacteria, improving the capability of resisting external pollution of skin, improving the immunity of the skin,

the invention has the beneficial effects that: the invention provides a baby infantile eczema repair cream which is added with a plurality of natural components, can achieve the drug effect similar to that of a hormone ointment, can be used for a long time, has light and moist skin and can effectively care delicate skin of a baby.

Detailed Description

The raw materials in the examples and comparative examples were purchased from the market, wherein a mixture of safflower (carthamus tinctorius) seed oil, bisabolol and vitamin E was purchased from korean biopspectrum, with a model number of MelaNo, and the product was a mixture of safflower seed oil, bisabolol and vitamin E, wherein the weight ratio of safflower seed oil, bisabolol and vitamin E was: safflower seed oil: bisabolol: vitamin E =81:17: 2;

a mixture of shea butter (Butyrospermum PARKII) fruit fat, chamomile (Chamomilla RECUTITA) leaf extract, Glycyrrhiza GLABRA (Glycyrrhiza GLABRA) root extract, centella asiatica (CENTELLA ASIATICA) extract, Rosmarinus OFFICINALIS (Rosmarinus OFFICINALIS) leaf extract, tocopherol (vitamin E), Scutellaria BAICALENSIS (Scutellaria BAICALENSIS) root extract, Camellia sinensis (CAMELLIA SINENSIS) leaf extract, and Polygonum CUSPIDATUM (Polygonum CUSPIDATUM) root extract was purchased from Korean BioSpectrum corporation and is available under the commercial model of CalmYang WAX;

a mixture of canola oil and rosemary (Rosmarinus OFFICINALIS) leaf extract is available from Guangzhou Narco chemical Co., Ltd under the model of Rosamox; -CO;

a mixture of dimethicone and dimethiconol was purchased from dow corning, usa under the trade designation DC 1403;

the mixture of the 1, 3-propylene glycol, the water and the CAMELLIA (Camellia JAPONICA) flower extract is purchased from Korea BioSpectrum company, the commercial model of the mixture is RedSnow, wherein the product is the mixture of the 1, 3-propylene glycol, the water and the CAMELLIA extract, and the content of the CAMELLIA extract is 2%;

the mixture of caprylhydroxamic acid, glyceryl caprylate and propylene glycol was purchased from Ezepine Biotech, Guangzhou under model number A91.

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

The formula of the raw materials for preparing the repair cream described in the examples 1-3 and the comparative examples 1-4 is shown in the table 1, and the preparation method comprises the following steps:

adding the raw materials A into an oil phase pot in sequence, stirring and heating to 75-80 ℃ until the raw materials are completely melted;

2. sequentially adding the raw materials B into a water phase pot, stirring and heating to 80-85 ℃, and homogenizing for 2 minutes until the raw materials are uniformly dispersed;

3. pumping the water phase pot body into an emulsifying pot, pumping the oil phase pot body into the emulsifying pot, stirring and homogenizing for 5 minutes until complete emulsification, and preserving heat for 10 minutes;

4. cooling to 55-60 deg.C under stirring, adding the raw materials of item C into the emulsifying pot, stirring and homogenizing for 3 min until emulsification is complete, and maintaining the temperature for 5 min;

5. continuously stirring the emulsifying pot, cooling to 40 ℃, adding the raw material D into the emulsifying pot, and stirring for 5 minutes until the raw material D is uniformly dispersed;

6. sampling and detecting various indexes, and filtering and discharging after the indexes are qualified.

Table 1 preparation raw material formulation (%) -of repair cream described in examples 1 to 3 and comparative examples 1 to 4

Example 5

Clinical trial

1 treating eczema and infantile eczema

1.1 case selection

1.1.1 diagnostic criteria

It is manifested as erythema, papule, lichenification, scaling, and pachynsis, accompanied by different degrees of pruritus, and skin lesions distributed on face and cheek.

1.1.2 inclusion criteria

(1) 1 month to 36 months of age of the month, with unlimited character;

(2) the skin lesions are located in the head and the cheek and have mild and moderate degrees;

(3) the guardian signs an informed consent, is willing to carry out according to the test requirements, receives skin detection and returns on time;

(4) no other skin diseases except eczema and infantile eczema;

(5) there is no systemic disease.

1.1.3 exclusion criteria

(1) (ii) a child suffering from contact allergy to the test sample;

(2) the rash is locally combined with virus or fungus to infect children;

(3) children with heart, liver, renal dysfunction and other serious systemic diseases;

(4) the glucocorticoid and the immunosuppressant are applied systemically within 4 weeks before the visit, or the glucocorticoid or the nonsteroidal anti-inflammatory drug is applied locally within 2 weeks;

(5) the product is not used as required, and the treatment is automatically stopped or other medicines are used together during the treatment period.

(6) Diseases that may affect the skin or the results of current disease-affecting tests;

(7) other dermatologists believe that the test results may be affected.

1.1.4 rejection Standard

The treatment of the infant patient was automatically terminated without using the test sample as specified.

1.2 methods of administration

160 children who met the above-mentioned case criteria (80 men and 80 women, age 1-34 months, course 1d-1 month) were randomly divided into 8 groups of 20 persons each. The eczema cream is uniformly applied to affected parts for 2-3 times per day for 5 days.

(1) And (3) healing: the symptoms of the children basically disappear, and the skin lesion is resolved by more than 90 percent;

(2) the effect is shown: the symptoms are significantly improved, and the skin lesion is resolved by greater than or equal to 75%;

(3) improvement: the symptoms are improved to a certain extent, and the skin damage is resolved by more than 60 percent;

(4) and (4) invalidation: the symptoms did not change any significantly.

1.4 results

The affected skin of the patient was observed 5 days after the administration. The results are shown in Table 2.

TABLE 2 treatment results of the repair creams described in examples 1 to 3 and comparative examples 1 to 3

Group of	Recovery (%)	Significant effect (%)	Improvement (%)	Null (%)	Total effective rate (%)
						Example 1	45%	35%	10%	10%	90%
Example 2	30%	35%	10%	25%	75%
						Example 3	35%	30%	15%	20%	80%
Comparative example 1	20%	30%	20%	30%	70%
						Comparative example 2	20%	35%	20%	25%	75%
Comparative example 3	25%	20%	25%	30%	70%
						Comparative example 4	20%	25%	20%	35%	65%

As can be seen from table 2, the repair creams described in examples 1 to 3 have a certain treatment effect on infantile eczema and infantile eczema, and the total effective rate is up to 90%, wherein the treatment effect feedback of example 1 is the best, and as can be seen from comparison between example 1 and comparative examples 1 to 4, the treatment effect of the repair cream lacking one or more of camellia seed oil, argania spinosa kernel oil, safflower seed oil, bisabolol, vitamin E, paeonol, clove oil, mandarin orange peel extract and chamomile oil is inferior to that of example 1, which indicates that each component can fully exert its effect in the repair cream, and is helpful for improving the treatment effect of the repair cream.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (1)

1. The infant infantile eczema repair cream is characterized by comprising the following components in parts by weight, based on 100 parts by weight: 8 parts of camellia seed oil, 6 parts of argania spinosa kernel oil, 0.81 part of safflower seed oil, 0.17 part of bisabolol, 0.02 part of vitamin E, 0.5 part of paeonol, 0.3 part of clove oil, 2 parts of mandarin orange peel extract, 0.1 part of chamomile oil, 0.1 part of a mixture of canola oil and rosemary leaf extract, 1 part of a mixture of 1, 3-propylene glycol, water and camellia extract, 2 parts of an anti-allergic agent, 0.2 part of natural borneol, 6 parts of glycerol, 2 parts of phytosterol oleate, 0.1 part of o-cymene-5-ol, 0.1 part of tocopherol acetate, 0.03 part of sodium hyaluronate, 1 part of erythritol, 0.2 part of allantoin, 5 parts of a saccharide isomer, 0.5 part of hydrogenated lecithin, 0.3 part of potassium cetyl phosphate, 1.5 parts of cetylstearyl alcohol, 1 part of hydroxyethyl acrylate/sodium acryloyldimethyl sulfonate copolymer, 0.02 part of EDTA, 0.2 part of polydimethylsiloxane, 1 part of mixture of polydimethylsiloxane and dimethiconol, 0.4 part of mixture of caprylyl hydroximic acid, glyceryl caprylate and propylene glycol, 0.2 part of p-hydroxyacetophenone and the balance of water;

the anti-allergic agent is a mixture of shea butter, chamomile leaf extract, Glycyrrhiza glabra root extract, centella asiatica extract, Rosemary leaf extract, vitamin E, Scutellaria baicalensis root extract, tea leaf extract and Polygonum cuspidatum root extract.