CN107115213A - A kind of skin cream with eczema repair function - Google Patents
A kind of skin cream with eczema repair function Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention discloses a kind of skin cream with eczema repair function, it is made up of following material：Hydrolecithin, laruyl alcohol phosphate potassium, camellia seed oil, evening primrose oil, cetostearyl alcohol, olive oil, vitamin E, phytosterols oletate, dimethyl silicone polymer, disodium ethylene diamine tetraacetate, polyglycereol 10, carbomer, arginine, Sodium Hyaluronate, wrinkle leaf lily magnolia bark extract, arhat cypress branch extract, pummelo peel extract, glycyrrhiza glabra root extract, purslane extract, Gotu Kola P.E, Punica granatum L. extract, carbohydrate isomer, glycerol caprylate, with decoyl hydroximic acid and water；This have the skin cream of eczema repair function not only property it is gentle, it is low stimulate, but also with good ph stability and the cold-resistant superperformance such as heat-resisting.
Description
Technical field
The present invention relates to a kind of skin cream with eczema repair function.
Background technology
Eczema belongs to the relatively common epidermis as caused by a variety of internal and external factors and the inflammatory dermatoses of high dermis.Its
Feature is feels, violent itch, and skin damaged polymorphy is symmetrical, has and oozes out tendency, the chronic course of disease, easy recurrent exerbation.Divide anxious
Property, subacute, chronic three phase.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plumpness.Some patients directly translate into chronic
Eczema.The features such as skin damaged has polymorphy, symmetry, itch and easy recurrent exerbation.
The morbidity of eczema is caused by many factors interact.Inherent cause has closely with certain form of eczema and heredity
Relation.Many researchs confirm that environmental factor is one of increased major reason of eczema illness rate.Environment include group environment with
Individual environment, the group environment pathogenic factor of the mankind refers to outdoor gas and water empty on a large scale, soil, radioactive source, the cause of large area
Quick pollen and vegetation, the gas of large area pass sensitization bacterium source etc..Individual subenvironment refers to the living environment of individual, due to the life of people
About 2/3 time, therefore, influence of the individual subenvironment to eczema was closer indoors.The influence of environmental factor is primarily referred to as
Increasing and complex environment allergen.Some eczemas are relevant with the infection of microorganism.These microorganisms include golden yellow
Staphylococcus, chlosma, source of the gas fungi such as Alternaria, branch spore are mould, putting mould, aspergillus fumigatus, reaping hook, mould, production is yellow blue or green
Mould, aspergillus niger and bread mold etc..The food variety of the mankind is extremely more, plant, animal class, mineral substance is generally can be divided into, in modern age
Food in also often apply some chemical syntheses food such as saccharin, acetic acid, citric acid, essence, synthetic dyestuffs etc..These foods
Thing can cause the allergy of food, so as to cause the generation of eczema.Food Biochemical Research is found, can be divided in the skin of banana
Histamine material is separated out, very high histamine composition, chicken liver, beef, perfume (or spice) are contained in banana, pineapple, eggplant, grape wine, yeast
Enteral also contains at a relatively high histamine, and causes the generation of eczema.Also a kind of is that the mood of people is also to cause eczema to produce
One of the reason for.
Eczema is divided into acute, subacute and chronic three types：
Acute eczema：This type eczema can occur at any position of whole body, but often relatively be easily seen in head, and four limbs bend side, the moon
The positions such as portion, brothers' back of the body.Often it is symmetric, is generally confined to some positions, and whole body universal eczema is very rare.Eczema
Skin lesion show as polymorphy, i.e. erythema, papule, papulo-vesicle, blister, erosion, ooze out, form a scab, the various fash such as furfur can
Cross-reference.That is, in same lesion, in contemporaneity, may occur in which above-mentioned more than 3~4 kinds infringements.Affected part inflammatory reaction
Generally more apparent, especially central part is more notable, often with it is rotten to the corn, ooze out but disease damage indefinite border Chu, swelling also compared with
Gently.Feel and itch very, its itch degree and site of pathological change, the difference of individual tolerance and difference.Itch with night more so, disease feelings
Severity, can influence sleeping eyes.The easy concurrent bacterial infection also because of itching, so as to trigger epifolliculitis, furuncle, impetigo, lymphatic vessel
The suppurative dermatosis such as inflammation, adenolymphitis.Acute eczema such as can obtain recovery from illness, but easily recurrence through appropriate disposal.Clinically also often
It was observed that being divided a word with a hyphen at the end of a line by this type eczema as subacute or chronic eczema.
Subacute eczema：When acute eczema inflammatory reaction alleviation, redness, ooze out obvious mitigation.Whole lesion using papule as
It is main, have a slight erosion, a small amount of sepage and with a little incrustation or the scales of skin that peel off, can then be referred to as subacute eczema.This phase eczema,
Subjectivity, which is itched still, to be present, and the course of disease is up to as long as several weeks.If characteristic of disease protracted course of disease person, can develop into chronic eczema；If processing
Owe to work as, disease feelings deteriorate rapidly drastic change, also reversible to switch to acute eczema.
Chronic eczema：The type eczema can at the beginning of morbidity just be in chronic type, but majority be from it is acute, it is subacute differentiation and
Into, be also shown in acute eczema repeatedly same position occur, be finally converted into chronic eczema.Chronic eczema is apt to occur in four limbs,
Such as brothers, shank, the fossa cubitalis, nest etc., it is distributed also how symmetrical.Skin damaged is often topical type, in pachyderma, infiltrates evident bright, often
Into lichenification, pigmentation is of common occurrence, and boundary is exceptionally clear.Patient often tells itching unbearably, heat or when night came
More so.The state of an illness is touching, rare recovery from illness for years.During this period, work as or diet irritable food as local treatment processing is deficient, can
Make chronic eczema acute attack, at this moment its clinical manifestation is such as acute eczema.
Meeting scar and pigmentation on skin, influence attractive in appearance after eczema is cured.
The content of the invention
In view of this, it is an object of the present invention to provide one kind, not only property is gentle, low stimulation, but also with good soda acid
The skin cream with eczema repair function of stability and the superperformance such as heat-resisting that resists cold.
In order to solve the above-mentioned technical problem, the technical scheme is that：
A kind of skin cream with eczema repair function, is made up of the material of following percentage by weight：Hydrolecithin
1.5%th, laruyl alcohol phosphate potassium 0.3%, camellia seed oil 6.0%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, olive
Fruit oil 2.0%, vitamin E 0.2%, phytosterols oletate 0.5%, dimethyl silicone polymer 1.0%, ethylenediamine tetra-acetic acid
Disodium 0.05%, Natrulon H-10 8.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia
Bark extract 0.5%, arhat cypress branch extract 0.5%, pummelo peel extract 0.5%, glycyrrhiza glabra root extract 0.5%, horse
Sativa extract 0.5%, Gotu Kola P.E 0.5%, Punica granatum L. extract 0.5%, carbohydrate isomer 3.0%, caprylic
Acid esters 0.2% and decoyl hydroximic acid 0.1%, surplus is water.
Further, the carbohydrate isomer be glucose, fructose, lactose, lactose product, mannose, galactolipin,
One kind in psicose.
Further, the wrinkle leaf lily magnolia bark extract contains magnolol magnolia obovata alcohol.
Further, the Punica granatum L. extract contains anthocyanidin, Punica granatum L. polyphenol and ellagic acid
The technology of the present invention effect major embodiment is in the following areas：It is prepared into using hydrolecithin as emulsifying agent liquid crystal emulsified
System, this system has same epidermis extremely similar structure, has good shield effectiveness to skin, is conducive to active ingredient again
Infiltration, it is soft outer equivalent to last layer is worn to fragile epidermis while be also equipped with good moistening effect and product use feeling
Clothing.
Embodiment
With reference to embodiments, the embodiment to the present invention is described in further detail, so that technical solution of the present invention
It is more readily understood and grasps.
A kind of skin cream with eczema repair function, is made up of the material of following percentage by weight：Hydrolecithin
1.5%th, laruyl alcohol phosphate potassium 0.3%, camellia seed oil 6.0%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, olive
Fruit oil 2.0%, vitamin E 0.2%, phytosterols oletate 0.5%, dimethyl silicone polymer 1.0%, ethylenediamine tetra-acetic acid
Disodium 0.05%, Natrulon H-10 8.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia
Bark extract 0.5%, arhat cypress branch extract 0.5%, pummelo peel extract 0.5%, glycyrrhiza glabra root extract 0.5%, horse
Sativa extract 0.5%, Gotu Kola P.E 0.5%, Punica granatum L. extract 0.5%, carbohydrate isomer 3.0%, caprylic
Acid esters 0.2% and decoyl hydroximic acid 0.1%, surplus is water.
The first composition is to the plant extracts at least containing more than one with notable antiallergic effect.Radix glycyrrhizae contains
A variety of chemical compositions, main component has glycyrrhizic acid, liquiritin etc..The chemical composition of radix glycyrrhizae is extremely complex, so far from radix glycyrrhizae
In the compound isolated have glycyrrhizin, enoxolone, liquiritin, isoliquiritin, neoliquriitin, neoisoliquiritin, radix glycyrrhizae
The tens of kinds of chemical combination such as plain, isoliquiritigenin and licoricidin, glycyrol, isoglycyrol, 7- methylcoumarins essence, umbelliferone
Thing.Radix glycyrrhizae has stronger anti-inflammatory and anti-metamorphosis, and the drug effect than sulfanilamide (SN) and antibiotic is good；Furthermore, radix glycyrrhizae has preferable
Anti-oxidant and Green Tea Extract effect.Purslane contains substantial amounts of norepinephrine and (contained in fresh purslane
0.25%), neurohormone (have and play vessel retraction effect, hypotension and the function of reducing tissue bleeding).Purslane is also
Containing many common nutrients (concentration is from low to high), including：Vitamin (vitamin A, vitamin B1, vitamin
B2, vitamin C, niacinamide, nicotinic acid, (- tocopherol, (- carotene etc.), mineral matter particularly potassium, aliphatic acid (particularly Asia
Numb acid, i.e. Ω -3, its concentration in purslane is highest in all leafy plants), glutathione, glutamic acid and asparagus fern ammonia
Acid.Other compositions include mucus, calcium oxalate, malic acid and the lemon being made up of the acid and neutrals of a part of known structure
Other useful materials such as lemon acid, dopamine and DOPA, cumarin, flavonoids, saponin and urea.Whole plant contains recklessly
Luo Busu；Vitamin C, B1, B2, PP；Ca, Mg, Na, K salt；Organic acid；Cigarette (alkali) acid and oxalic acid；Norepinephrine and double Huangs
Ketone liquiritin.Worldwide this plant is eaten as salad or vegetables, and can be used to treat as medicinal material
A variety of diseases, including headache, stomachache, painful urination, enteritis, mastitis, puerpera's milk deficiency and postpartum haemorrhage.External application then can be with
For treating burn, otalgia, insect bites, inflammation, cutaneous pain, ulcer, itch (skin is itched) eczema and abscess.Purslane
Extract solution has been developed that the active matter as anti-inflammatory, anti-irritant and antiallergic in cosmetics.Therefore, it is currently preferred to have significantly
The plant extracts of antiallergic effect is glycyrrhiza glabra root extract, purslane extract..
Second of composition is the plant extracts for having stronger bactericidal anti-inflammatory effect containing more than one.Wrinkle leaf lily magnolia bark
Extract is rich in magnolol magnolia obovata alcohol, and research has shown that wrinkle leaf lily magnolia bark extract has strong antibacterial action, to streptococcus mutans
Minimum inhibitory concentration (MIC) be 6.3 μ g/ml, its antibacterial action is more stronger than berberine.Its aqueous solution is to Staphylococcus aureus
Bacterium, sarcine and hay bacillus have certain bacteriostasis；Arhat cypress branch extract can be used as food preservative.Thujopsis dolabrata is carried
Take the main component of thing to keep side element or hinokitol or thujaplicin, have tri- kinds of isomers of α, β, γ.α-keep the plain fusing point 82 in side
DEG C, β-keep plain 52~52.5 DEG C of the fusing point in side, γ-keep plain 82 DEG C of the fusing point in side.Mixture is white to yellow crystal or crystallinity powder
End, with the distinctive fragrance of Thujopsis dolabrata.Thujopsis dolabrata extract has very strong sterilizing ability, has to bacterium, mould, yeast etc.
Fine inhibition；Pummelo peel extract, pummelo peel extract is stronger to the inhibitory action of Escherichia coli and staphylococcus aureus, its
MIC is 2.5%, and the inhibitory action to salmonella is weaker, its MIC ＞ 2.5%, the suppression of pH value and temperature to pummelo peel extract
Bacterium activity has an impact, and fungistatic effect is preferable under the conditions of slant acidity.Therefore currently preferred group there is stronger sterilization to imitate
The plant extracts of fruit is wrinkle leaf lily magnolia bark extract, arhat cypress branch extract and pummelo peel extract.
The third composition at least contains a kind of plant extracts with skin contraction effect.Punica granatum L. extract contains abundant
Anthocyanidin, Punica granatum L. polyphenol and ellagic acid.In terms of existing Japan and France are used for cosmetics, granatum ellagic acid has good
Lipoid peroxidization resistant, the effect of anti-aging can be played by being added in cosmetics, and granatum contains the tannin of volume, has
Anti-inflammatory and convergent effect, pomegranate rind extract show strong suppression to melanocyte activity, are that good cosmetics add
Plus agent.In terms of pharmacology, Punica granatum L. extract has：1. astriction, granatum contains matter of mixing more containing, when them and mucous membrane, the surface of a wound etc.
After contact, it can precipitate or solidify local protein, make to form comparatively dense protective layer on surface, contribute to local woanded surface to be cured
Close or protect local from stimulating；2. antibacterial action, granatum decoction is in vitro to 4 clocks such as in will he, Amur, Fu Shi and Song
Shigella dysenteriae has antibacterial action, acts on most strong to will he, Amur, Fu Shi take second place, and acts on poor to bacterium sonnei.Compare
400 kinds of Chinese medicines are for sterilizing power in the test tube of typhoid bacillus, comma bacillus, staphylococcus etc., it was demonstrated that granatum suppresses typhoid fever bar
The effect of bacterium is most strong, in addition, experiment in vitro proves thin mattresses a variety of to tubercle bacillus, Escherichia coli, proteus, Pseudomonas aeruginosa etc.
There is inhibitory action, above antibacterial action may be relevant with contained a large amount of matter of mixing；3. antivirus action, chick embryo method it is demonstrated experimentally that
Granatum decoction, which is diluted to 1: 1 ten thousand -1: 10 ten thousand, still suppression influenza virus (PR8 strain of influenza virus type A).Using cell culture skill
Art, it was demonstrated that matter of mixing is the active ingredient of the anti-genitals herpus vivus of granatum.Its feature can not only suppress virus in the cell
Propagation, what is more important show stronger direct killing virus and prevent and adherent cell effect；4. anthelmintic action, stone
Pomegranate skin decoction has anthelmintic effect.Its mechanism system acts on the muscle of parasite, it is sunk into contracts last, and have expelling parasite it
Effect.Therefore, the currently preferred plant extracts with skin contraction effect is Punica granatum L. extract.
4th kind of composition is that at least have the significant composition of moistening effect containing a kind of.Carbohydrate isomer
(saccharide isomerate) is colourless or micro- yellow transparency liquid, a kind of natural moisture preserving of extraction from sugarcane carbohydrate synthesis
Agent, assists the keratin in moisture content combined with stratum corneum, with up to moistening effect.It is a kind of good water-loss reducer and emollients.Have
Epidermal layer cells, lifting skin moisturizing ability, the isomerization D- glucans manufactured via Measurement for Biochemistry are repaired, is had and people
The close composition structure of body cuticula, can be combined with epsilon-amino acid functional group using on skin, firmly be combined just as magnetite,
It long-acting can maintain the hydromagnetic field energy power of skin.Therefore be known as again：Water lock magnetite, its main component is：Glucose, fructose,
Lactose, lactose product, mannose, galactolipin, psicose.Therefore, it is currently preferred that there is moistening effect significantly to combine
Thing is carbohydrate isomer.
5th kind of composition is that at least wherein have healing of wound and the plant extracts of scar repair containing a kind of.Product
Snow grass contains a variety of triterpenes, wherein including α-amyrin structure.Main component is Asiaticoside, asiatic acid and hydroxyl product
Avenge oxalic acid.Found by the scientific researches of more than 20 years, Gotu Kola P.E can promote collagen I and III synthesis, while
The secretion (synthesis of such as hyaluronic acid) of mucopolysaccharide can be promoted, increase the water conservation degree of skin, activation updates Skin Cell, makes skin
Releive, lifted and rich in reflecting feel；On the other hand testing research is arranged by cDNA and also found that Gotu Kola P.E also has into
The activation of fibrocyte gene, can strengthen the vigor of skin basal layer cell, keep elasticity of skin and consolidation sense, smooth face
Portion's fine wrinkles.By experiment, it was also found that acting in vitro culture using the asiaticosid and madecassoside of various dose
After fibroblast (HumanSkinFibroblast, HSFb), pass through the method determination experiment group of radio-immunity and blank control
I procollagen type aminoterminals peptide former (P I NP) and type III precollagen aminoterminal peptide former (PIII NP) contain in group cell supernatant
Amount.As a result show：1. compared with blank control group, asiaticosid and madecassoside can effective stimulus in vitro culture HSFbP
I NP and PIIINP secretion；2. asiaticosid and madecassoside stimulate the biology of target cell P I NP and PIIINP secretion
Obvious dose-effect relationship is presented in effect；3. in the μ g/mL dosage of 10 μ g/mL~150, Ad stimulates HSFb P I NP secretion
Show the bioactivity more stronger than Md.Therefore, the currently preferred plant with healing of wound and scar repair carries
It is Gotu Kola P.E to take thing.
This five kinds are chosen the natural function composition come, and the symptom of formation mechenism and affected skin from eczema is set about, adopted
" from outside to inside ", " by mark to originally " are taken, the maintenance scheme of multipath solves the problems, such as skin eczema.
Both effectiveness test：
Object and method
Object：Take random, open, Self-controlled study.The local eczema 29 of Guangzhou thoracic cavity hospital dermatology department is chosen,
Male 17, female 12, it is 37~77 years old age, average 52.1 years old.
Inclusion criteria：1. glucocorticoid, antibiotic etc. are not taken in 1 week before clinical observation, and do not make during observing
Use said medicine；2. do not indulged in excessive drinking during observing, excessive maror is not eaten；3. without using other skin care item and skin during observing
Medication.
Method
Treatment method
Control group conventionally, patient daily sooner or later twice, by Irrigation it is clean after eczema repair cream is uniformly applied to
Affected part
Evaluation method
Cure：Erythema is disappeared, and blister incrustation, no scratchiness, epidermis drying is slept without sepage, no heating, no recurrence；
Effectively：Erythema disappears, and blister diminishes, local occasionally to have itch, epidermis humidity or a little sepage, does not influence to sleep and live, does not send out
Heat；It is invalid：Substantially, blister becomes big or increasing number to erythema, and local scratchiness is strong, and epidermis has purulent secretion to ooze out, influence
Sleep and life, and have heating.
Statistical method data use SPSS13.0 software row Wilcoxon rank tests, inspection level a==0.05.
As a result
24, effective 5, invalid 0 are cured, effective percentage is 100%.
Foregoing skin care compositions can by by required composition in suitable container, at ambient conditions
Its mixing is prepared, any conventional mixing apparatus well known in the art can be used during preparation, such as：Emulsifying homogeneous pot etc..It is mixed
Needed during conjunction the molten and water-soluble difference Hybrid Heating of oil to 80 DEG C, then oil phase is mixed with water conjunction stirring homogeneous, cools to
Innate efficacy thing is added at 45 DEG C.
The technology of the present invention effect major embodiment is in the following areas：It is prepared into using hydrolecithin as emulsifying agent liquid crystal emulsified
System, this system has same epidermis extremely similar structure, has good shield effectiveness to skin, is conducive to active ingredient again
Infiltration, it is soft outer equivalent to last layer is worn to fragile epidermis while be also equipped with good moistening effect and product use feeling
Clothing.
Certainly, it is the representative instance of the present invention above, in addition, the present invention can also have other a variety of specific implementations
The technical scheme of mode, all use equivalent substitutions or equivalent transformation formation, all falls within the scope of protection of present invention.
Claims (4)
1. a kind of skin cream with eczema repair function, it is characterised in that be made up of the material of following percentage by weight：Hydrogenation
Lecithin 1.5%, laruyl alcohol phosphate potassium 0.3%, camellia seed oil 6.0%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%,
Olive oil 2.0%, vitamin E 0.2%, phytosterols oletate 0.5%, dimethyl silicone polymer 1.0%, ethylenediamine
Tetraacethyl disodium 0.05%, Natrulon H-10 8.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf
Lily magnolia bark extract 0.5%, arhat cypress branch extract 0.5%, pummelo peel extract 0.5%, glycyrrhiza glabra root extract
0.5%th, purslane extract 0.5%, Gotu Kola P.E 0.5%, Punica granatum L. extract 0.5%, carbohydrate isomer
3.0%th, glycerol caprylate 0.2% and decoyl hydroximic acid 0.1%, surplus is water.
2. there is the skin cream of eczema repair function as claimed in claim 1, it is characterised in that the carbohydrate isomer
For one kind in glucose, fructose, lactose, lactose product, mannose, galactolipin, psicose.
3. there is the skin cream of eczema repair function as claimed in claim 1, it is characterised in that the wrinkle leaf lily magnolia bark is carried
Thing is taken to contain magnolol magnolia obovata alcohol.
4. there is the skin cream of eczema repair function as claimed in claim 1, it is characterised in that the Punica granatum L. extract contains
Anthocyanidin, Punica granatum L. polyphenol and ellagic acid.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107744480A (en) * | 2017-10-26 | 2018-03-02 | 广州市禾基生物科技有限公司 | A kind of water white transparency face cream and preparation method thereof |
| CN108245442A (en) * | 2018-02-05 | 2018-07-06 | 无锡简玺生物科技有限公司 | A kind of repair cream suitable for eczema skin |
| CN108743453A (en) * | 2018-09-10 | 2018-11-06 | 无限极（中国）有限公司 | A kind of compounding layered liquid crystal emulsifier and its application and the cosmetics with layered liquid crystal structure |
| CN109568190A (en) * | 2018-12-30 | 2019-04-05 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application for repairing sunburn |
| CN109674374A (en) * | 2019-01-24 | 2019-04-26 | 宁波大学 | A kind of tearable multifunctional towel and preparation method thereof |
| CN110063927A (en) * | 2019-05-27 | 2019-07-30 | 贝德氏（上海）健康科技股份有限公司 | A kind of antiallergic skin care item and its production method |
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| CN110279628A (en) * | 2019-07-22 | 2019-09-27 | 深圳市润科生物科技有限公司 | A kind of cosmetic composition and its preparation of moisturizing of releiving |
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| CN113041182A (en) * | 2019-12-27 | 2021-06-29 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, anti-aging skin lightening lotion containing collagenase inhibitor and preparation method |
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| CN107744480A (en) * | 2017-10-26 | 2018-03-02 | 广州市禾基生物科技有限公司 | A kind of water white transparency face cream and preparation method thereof |
| CN108245442A (en) * | 2018-02-05 | 2018-07-06 | 无锡简玺生物科技有限公司 | A kind of repair cream suitable for eczema skin |
| CN108743453A (en) * | 2018-09-10 | 2018-11-06 | 无限极（中国）有限公司 | A kind of compounding layered liquid crystal emulsifier and its application and the cosmetics with layered liquid crystal structure |
| CN109568190A (en) * | 2018-12-30 | 2019-04-05 | 广州瑞誉化工科技有限公司 | A kind of skin composition and its preparation method and application for repairing sunburn |
| CN109674374A (en) * | 2019-01-24 | 2019-04-26 | 宁波大学 | A kind of tearable multifunctional towel and preparation method thereof |
| CN110063927A (en) * | 2019-05-27 | 2019-07-30 | 贝德氏（上海）健康科技股份有限公司 | A kind of antiallergic skin care item and its production method |
| CN110200826A (en) * | 2019-06-26 | 2019-09-06 | 上海大绿电子商务有限公司 | A kind of compound plant polypeptide maintenance Essence |
| CN110279628A (en) * | 2019-07-22 | 2019-09-27 | 深圳市润科生物科技有限公司 | A kind of cosmetic composition and its preparation of moisturizing of releiving |
| CN110812295A (en) * | 2019-11-26 | 2020-02-21 | 广州瑞誉化工科技有限公司 | Infantile tinea-repairing cream |
| CN110812295B (en) * | 2019-11-26 | 2022-03-25 | 广州瑞誉化工科技有限公司 | Infantile tinea-repairing cream |
| CN113041182A (en) * | 2019-12-27 | 2021-06-29 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, anti-aging skin lightening lotion containing collagenase inhibitor and preparation method |
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