RU2288734C1 - Composition for skin care possessing anti-itching effect - Google Patents

Abstract

FIELD: medicine, dermatology, pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to compositions used for skin care in itching dermatosis. The composition comprises essential oils of different plants, citrosept and cedar nut oil prepared by cold pressing method. Proposed composition possesses the stable effect on allergic and inflammatory processes and can be used as an accessory agent in treatment of itching dermatosis and allergic responses after hirudotherapy.

EFFECT: valuable medicinal properties of composition.

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Description

The invention relates to medicine, in particular to compositions for skin care for pruritic dermatoses: atopic dermatitis, allergic reactions after leech attachments and urticaria rashes of various origins.

It is known to use for itchy dermatoses, primarily for atopic dermatitis, ointments containing steroid hormones: Advantan, Afloderm, Belosalik, Dermazolone, Diprosalik ,, Dermoveit, Fluorocort (Russian Medicines Register “RLS-Doctor”, 2002, p. 210, 258, 269, 395, 404. 394, 861, respectively) and others. The basis of their action is the suppression of the allergic and inflammatory reaction of the skin with hormonal agents. Their shortcomings include the short duration of action and the need for systematic use in the future.

Also known is the transdermal balm "Alleron" (Appendix to the Mirra-Lux directory, 2003, p. 25), which served as a prototype, which includes oils: sesame, grape, jojoba, essential oils of cloves, monarda, mint, myrrh, tea tree , lemon, lavender, licorice extracts, string, rosehip oil extract. However, the antipruritic effect of the balm is short-lived.

The objective of the invention is to develop a composition of natural origin for a more persistent effect on allergic and at the same time inflammatory processes that occur in the skin.

The problem is solved by a composition containing plant essential oils, citrocept and cold pressed pine nuts oil with a large amount of fat-soluble vitamins, on an emulsion basis, including olive, corn or sunflower oil, chicken oil, petroleum jelly, beeswax, water, emulsifiers (lanolin, emulsion wax, monoglycerides, for example, Dimodan CP, sorbitan oleate, lipid complex 2, etc.) to obtain a cream of the necessary consistency and rapid absorption, with the following content of components (ma from.%):

lemon balm essential oil 0.3-1.5 tea tree essential oil 0.3-1.5 lavender essential oil 0.3-1.5 citrosept 2.0-6.0 cold pressed pine nuts oil 2.0-6.0 emulsion base up to 100.0

We give examples of the preparation of an emulsion base.

Example 1

The emulsion base is prepared according to generally accepted rules by fusion of 7.0 g of petroleum jelly, 0.5 g of beeswax, 5.8 g of lanolin, 1.0 g of CP dimodan (or emulsion wax, or sorbitanoleate, or lipid complex 2, or another emulsifier) and dispersing 7.0 g of vegetable oil (sunflower, or soybean, or corn, or olive, or other), 3.0 g of chicken oil. The ratio of the components of the cream base may vary. If necessary, additional ingredients can be introduced into the emulsion base to ensure satisfactory consumer qualities of the cream (antioxidants, preservatives, for example, methyl paraben, stabilizers, antiseptics, etc.).

Example 2

An emulsion base is prepared by fusing 6.0 g of perfume oil, 4.8 g of lanolin, 0.5 g of ceresin, 0.5 g of paraffin, 0.5 g of beeswax, by adding emulsifiers: lipid complex - 2.0 g, sorbitanoleate - 2 , 0 and distilled monoglycerides - 2.0, emulsion wax - 4.0; the addition of vegetable oil - 5.0 g, chicken (lipocomb A) oil - 3.0 and propyl ester of paraoxybenzoic acid - 0.1 g.

We give examples of the proposed composition.

Example 3

Take 24.3 g of the emulsion base obtained in example 1, and after cooling to 45 ° C, it is slowly introduced with thorough stirring on a turbine or other type of mixer (4-5 thousand revolutions per minute) for 25 minutes 6.0 g cold pressed pine nuts oil and 6.0 g of an alcoholic solution of citrocept dissolved in 52.2 ml of water.

1.5 g of lemon balm essential oil, 1.5 g of tea tree essential oil and 1.5 g of lavender essential oil are introduced into the emulsion obtained at the same rotor speed for 3 minutes until a homogeneous mass of creamy consistency is formed.

The composition of the prepared cream composition has the following ratio of components, wt.%

lemon balm essential oil 1,5 tea tree essential oil 1,5 lavender essential oil 1,5 citrosept 6.0 cold pressed pine nuts oil 6.0 emulsion base up to 100.0

Example 4

After 30.4 g of the emulsion base obtained according to Example 2, after cooling to 45 ° C, slowly add it with thorough stirring on a turbine or other type of mixer for 25 minutes, 2.0 g of cold pressed pine nuts oil and 2.0 g of alcohol a solution of citrosept, previously dissolved in 64.7 ml of distilled water. After cooling the resulting mass to 36 °, a mixture of essential oils is introduced into it: lemon balm essential oil 0.3 g, tea tree essential oil 0.3, lavender essential oil 0.3 further, as in example 3.

The composition of the prepared composition has the following ratio of components, wt.%:

lemon balm essential oil 0.3 tea tree essential oil 0.3 lavender essential oil 0.3 citrosept 2.0 cold pressed pine nuts oil 2.0 emulsion cream base up to 100.0

The proposed composition was tested on volunteers on an outpatient basis. There were 23 patients under observation: atopic dermatitis - 14 people; allergic skin reaction in places of leech attachments - 6 people; eczema - 3 people.

Patients used the proposed composition to relieve itching, rubbing cream in the area of affected skin 2-3 times a day. In all patients, the use of cream was monotherapy. The best results after applying the proposed composition were noted in patients with itchy skin at the site of suction of leeches. The itching subsided several hours after applying the cream. In patients with atopic dermatitis, itching subsided in the range from 3-7 days to 2-3 weeks. Initially, patients applied the cream to the skin 3-9 times a day. As the itching subsided, the frequency of its use was reduced: patients used it only before bedtime. During the period of applying the cream, patients did not use hormonal ointments.

In patients with eczema, no clear improvement was noted, possibly because weeping eczema was observed in these patients. As you know, ointments with weeping eczema do not bring relief to patients.

We give specific examples of the application of the proposed composition.

Example 5

Patient K., 12 years old, has been observed for 3 years due to atopic dermatitis occurring with frequent exacerbations. At the age of 8 months, the patient developed exudative diathesis. At the age of 4, neurodermatitis (atopic dermatitis) was diagnosed. The disease proceeded with frequent exacerbations and severe skin itching. Hormonal ointments were used for treatment.

The reason for the appeal was another exacerbation and desire of the mother to avoid the use of hormonal drugs.

From objective data: hyperemia and swelling of the skin, papules covered with bran-shaped scales, lichenization and excoriation, cracks and blood crusts. According to the mother and the girl, itchy skin intensified after contact with water. The patient was recommended to use the proposed composition obtained in example 4. She applied the cream with a thin layer on the affected skin at least 3 times a day and always before bedtime. Reduction of itching was noted 2-3 days after the start of using the proposed composition. When re-examined after 2 weeks, a decrease in hyperemia and swelling of the skin, the absence of cracks, scratches and blood crusts were noted. The treatment lasted 3-4 weeks. After that, the patient stopped using this cream and after bathing she used the usual skin softening agents such as lanolin, spermaceti or chamomile cream, which did not bring relief before the course of treatment. For the entire observation period, the patient does not use hormonal ointments and exacerbations stop only the proposed tool.

Example 6

Patient N. 51 years old complained of severe itching in the lower leg and knee joint after 2 sessions of hirudotherapy for arthritis of the left knee joint. Prefixes of leeches were carried out in the area of the front surface of the knee joint above the patella and on the sides of it. The interval between the procedures was 3 days. Increasing itching appeared the day after the second session of the prefix of 4 leeches.

From objective data; hyperemia and swelling of the skin in the area of the leech bite, brownish-red crusts, swelling of the lower leg skin.

The patient was recommended the use of the proposed composition according to example 3, which she applied a thin layer without rubbing 2-3 times a day in the area of skin wounds and altered skin. The patient did not take antihistamines. Reduction of itching was noted on the 2nd day of application of the cream, and complete cessation - on the 3rd day. Along with this, edema significantly decreased.

Comparison of the pharmacological activity of the proposed structure and prototype - transdermal balm "Adler" - revealed a shorter duration of the antipruritic effect of the prototype and the need for a longer use of the balm. In the control group of 10 patients using the balm, an additional prescription of antihistamines was required. Patients were forced to use the tool more than 4 times a day due to unstable antipruritic effect or switch to hormonal drugs. On the contrary, the majority of patients using the proposed composition were able to avoid the use of hormonal drugs.

Thus, the proposed composition has a longer antipruritic and anti-inflammatory effect and can be used as an auxiliary external agent in the treatment of pruritic dermatoses.

Claims (1)

Composition for skin care with antipruritic effect, including essential oils of tea tree and lavender on an emulsion basis, characterized in that it additionally contains citrocept, cold pressed pine nut oil, lemon balm essential oil in the following ratio, wt.%: Melissa essential oil 0.3-1.5 Tea Tree Essential Oil 0.3-1.5 Lavender essential oil 0.3-1.5 Citrosept 2.0-6.0 Cold Pressed Pine Nuts Oil 2.0-6.0 Emulsion base Up to 100.0