KR20180092256A - Moisturizing cosmetic composition for sensitive skin - Google Patents

Abstract

The present invention relates to a moisturizing cosmetic composition for sensitive skin. The composition has a weakly acidic liquid crystal emulsion formulation which contains carrot extract oil and phytosterol as a main ingredient and a skin lipid component for enhancing skin barrier function as an auxiliary ingredient, as active ingredients for alleviating sensitive skin symptoms. The moisturizing cosmetic composition for sensitive skin according to the present invention can alleviate symptoms such as itching, burning, stinging, and pulling, which are felt as subjective symptoms without any special symptoms, and can alleviate symptoms such as erythema, redness, keratinization, and dryness, which are visible symptoms. Also, the composition can alleviate symptoms accompanying various dermatitis such as atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, and rosacea-like dermatitis. Therefore, the composition can provide an excellent effect as an adjuvant for moisturizing cosmetics and medicines.

Description

[0001] MOISTURIZING COSMETIC COMPOSITION FOR SENSITIVE SKIN [0002]

The present invention relates to a moisturizing cosmetic composition for sensitive skin, and more particularly, to a skin moisturizing cosmetic composition containing a carrot extract oil and phytosterol as main active ingredients in order to provide an optimal moisturizing cosmetic for sensitive skin, and a skin barrier such as ceramide, cholesterol, Which is capable of enhancing the function of the skin, and a weakly acidic liquid crystal emulsion formulation containing the skin lipid component as an auxiliary ingredient.

Recently, many people who use cosmetics due to western lifestyle or changes in the surrounding environment have continuously increased their skin as a sensitive skin, and accordingly, there is a need for suitable moisturizing cosmetics.

In general, sensitive skin is characterized by subjective symptoms without any visible symptoms, such as itching, burning, stinging, tightening, etc., It can be divided broadly into cases involving a variety of dermatitis such as atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, injection, and the like.

At this time, especially when dermatitis is accompanied, proper dermatological treatment is required, and at the same time, it is very important to use a moisturizing agent (cosmetic for sensitive skin) not containing steroid ingredient.

On the other hand, the inflammatory reaction caused by the skin weakens the normal skin barrier function, thereby failing to adequately protect the various stimulants, thereby increasing the immune response or inducing an excessive antigen-antibody reaction. As a result, And erythema may be exacerbated or sensitized skin may be overexposed to mild stimuli.

Topical steroids, which are widely used for the treatment of allergies and eczema, are widely used as first-line treatments because of their excellent therapeutic effect and low cost. However, when used for a long time, side effects such as skin atrophy, capillary vasodilation and steroid acne And the risk of erythema deterioration if used continuously.

In addition, tacrolimus or pimecrolimus, which has been developed as a substitute for tacrolimus, has few side effects such as skin atrophy and capillary vasodilation. However, skin irritation such as burning sensation And it is difficult to apply it to sensitive skin patients.

The principle of safe treatment of erythematous inflammation and inflammatory skin diseases is to prevent factors that cause first, to restore skin barrier function by using appropriate irritant-free moisturizing agent, to treat inflammation of skin by reducing the inflammation reaction through proper drug prescription .

In recent years, many consumers think of themselves as sensitive skin. In dermatology, it is important to use appropriate moisturizing agents for treating erythema and redness due to various dermatitis. Therefore, a moisturizing agent for sensitive skin including them is an indispensable product.

Examples of conventional prior art documents related to the present invention include the following.

Phytother Res. 2013; 27 (5): 737-44 suggests that carrot extract oil extracted with an organic solvent has antioxidant and anticancer effects at the cellular level, but this is to examine the pharmacological effects of carrot as a food, But not for cosmetic raw materials for application to.

Exp Biol Med (Maywood). 2014; 239 (4): 454-64, has shown that beta-sitosterol, a typical phytosterol, has anti-inflammatory effects in a mouse model of atopic dermatitis. However, this phytosterol ingredient is not the efficacy for various symptoms of sensitive skin.

On the other hand, J. Dermatol. According to the results of analysis of skin barrier function and ceramide content in 50 susceptible 20- to 40-year-old subjects, 20 susceptible skin group and 30 non-susceptible skin group were classified according to 2012; 39 (3): 295-300, In the sensitive skin group, ceramide is decreased in all the measured areas and the skin barrier function is decreased. Especially, the difference in the face area is statistically significant or distinct.

Also, Exp. Biol. Med. (Maywood). In 2014; 239 (4): 454-64, the content of ceramide in various dermatitis, which can be regarded as sensitive skin accompanied by dermatitis, was examined. As a result, the total amount of ceramide was decreased in various dermatitis such as dryness in winter, contact dermatitis and atopic dermatitis . This suggests that weakening of the skin barrier function by ceramide reduction may be explained as a cause of sensitive skin.

Exp. Dermatol. 2015; 24 (3): 179-180, serine protease is activated when skin pH rises, destroying enzymes important for generating skin lipid components, resulting in reduction of skin lipid components, It inhibits these functions by degrading the corneodesmosome, which plays an important role in the cohesion and integrity of the stratum corneum. Activation of protease activated receptor 2 (PAR2) by the activated serine protease results in secretion of stratum corneum in the stratum corneum Inhibiting and promoting the production of inflammatory cytokines such as damage to the skin barrier and induction of various dermatitis. This means that the abnormality of the skin pH can also be a cause of the sensitive skin.

On the other hand, there are some examples in which a water-soluble carrot extract is used as a raw material for cosmetics. However, there is no known example of applying a fat-soluble carrot extract oil to cosmetics. In particular, the efficacy for improving various symptoms of sensitive skin There is not.

The optimal moisturizing cosmetic composition containing the above-mentioned major cause of the sensitive skin and the active ingredient for improving it has not been proposed yet. In recent years, as a means of improving the quality of the moisturizing cosmetic composition, As the present inventors have recognized, there is a moisturizing cosmetic composition which improves various symptoms of sensitive skin using carrot extract oil and phytosterol ingredient. I do not.

 Phytother Res. 2013; 27 (5): 737-44.  Exp. Biol. Med. (Maywood). 2014; 239 (4): 454-64.  J. Dermatol. 2012; 39 (3): 295-300.  Exp. Biol. Med. (Maywood). 2014; 239 (4): 454-64.  Exp. Dermatol. 2015; 24 (3): 179-180.

A first object of the present invention is to provide a moisturizing cosmetic composition for skin which is optimal for the improvement of various sensitive skin symptoms.

The second object of the present invention is to provide a method of treating a patient suffering from a symptom such as subjective symptoms that show sensitive nervous responses such as itching, burning, stinging or pulling, and symptoms such as atopic dermatitis, seborrheic dermatitis, The present invention is to provide a moisturizing cosmetic composition for sensitive skin which can effectively improve sensitive skin symptoms accompanied by various dermatitis such as irritant or allergic contact dermatitis and injection.

A third object of the present invention is to provide a pharmacologically acceptable phytosterol ingredient having a regular arrangement of a lamellar liquid crystal structure at the emulsifying interface to give a high temporal stability and a liquid emulsifier type To provide an optimal moisturizing cosmetic composition for skin.

It is an object of the present invention to provide a skin moisturizing cosmetic composition having a weakly acidic liquid crystal emulsifying composition containing an extract of carrots and phytosterol as a main component and a skin lipid component for improving skin barrier function as an auxiliary component, Can be achieved smoothly by the composition.

The carrot extract oil may be contained in an amount of 0.5 to 50% by weight based on the total weight of the composition, and the phytosterol may be contained in an amount of 0.1 to 5% by weight based on the total weight of the composition.

The skin lipid component for enhancing skin barrier function includes a mixture of ceramide, cholesterol and fatty acid. The content of the above-mentioned mixture may be 1 to 5 wt% based on the total composition weight, and the acidity of the above- 3.5 to 5.5.

Further, the liquid crystal emulsion formulations, based on the entire composition of 0.5 to 3.0% by weight glyceryl stearate, by weight in non-ionic emulsifiers, cetearyl olivate and / or sorbitan olivate 0.5 to 3.0% by weight, C _{14- 22} alcohols and / or C _{12- 20} alkyl glucoside comprises from 0.5 to 3.0 wt%, or around the composition based on the weight of the glyceryl stearate 0.5 to 3.0% by weight, cetearyl olivate and / or sorbitan olivate 0.5 to 3.0 wt%, polyglyceryl stearate, including 0.5 to 3.0 wt%, or around the reference composition to 0.5 to 3.0% by weight glyceryl stearate, by weight, C _{14- 22} alcohol and / or C _{12- 20} alkyl glucoside 0.5 to 3.0 % by weight of polyglyceryl-may comprise a stearate, 0.5 to 3.0% by weight, a higher fatty alcohol as the former composition based on the weight of the fatty alcohol PO 3 to 5% by weight of C _16-24 Can.

The above-mentioned sensitized skin symptom may be caused by subjective symptoms such as itching, burning, stinging or pulling, and symptoms such as atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis , Or injection (Rosacea). The above-mentioned moisturizing cosmetic composition for sensitive skin can be applied for alleviation or alleviation of these symptoms.

The moisturizing cosmetic composition for sensitive skin according to the present invention is characterized by containing carrot extract oil and phytosterol as main active ingredients and having a weak acidic liquid crystal oil oil supplemented with a skin lipid component capable of enhancing the skin barrier function such as ceramide, cholesterol, By making the formulation, various symptoms of sensitive skin can be improved and an optimal moisturizing cosmetic for sensitive skin can be provided. More specifically, symptoms such as itching, burning, stinging and pulling can be improved without subjective symptoms, and symptoms such as erythema, flushing, keratinization and dryness can be improved by apparent symptoms In addition, when it is accompanied by various dermatitis such as atopic dermatitis, seborrheic dermatitis, irritant or allergic contact dermatitis, injection and the like, it can give a good effect as a moisturizing cosmetic composition and as an adjuvant for medicines.

1 is a polarized microscope photograph of the liquid crystal emulsion form of Example 1 in which a liquid crystal structure is formed at the emulsion interface.
FIG. 2 is a photograph of a clinical test showing that the symptom of flushing is improved by applying the sensitive skin moisturizing cosmetic composition of Example 1 to a representative type skin of a sensitive skin.

Hereinafter, the present invention will be described in detail.

The moisturizing cosmetic composition for sensitive skin according to the present invention may exhibit sensitive nervous reactions such as itching, burning, stinging and pulling due to subjective subjective symptoms without any visible symptoms, and it may be caused by visible symptoms such as erythema, And the like, and can be usefully applied to sensitive skin showing various skin symptoms such as atopic dermatitis, seborrheic dermatitis, irritation or allergic contact dermatitis, and cases involving various dermatitis such as injection.

The moisturizing cosmetic composition for sensitive skin according to the present invention comprises a carbohydrate extract oil and a weakly acidic liquid crystal emulsion formulation containing phytosterol as a main component and supplementing a skin lipid component capable of enhancing skin barrier function such as ceramide, cholesterol and fatty acid I have.

First, the carrot extract oil according to the present invention is an oil component extracted by organic solvent extraction or carbon dioxide supercritical extraction method in carrot, dried carrot or carrot seed before drying, and is rich in carotene which is a precursor of vitamin A, and polyphenol, sterol , Wax, fatty acid and so on, it has high antioxidant effect.

Specific methods for making the carrot extract oil can be extracted by a high-temperature compression method, a supercritical extraction method using carbon dioxide, an organic solvent extraction method using an organic solvent such as hexane, and the like, and most preferably, the supercritical extraction method.

In the case of the high-temperature squeezing method, the dried carrots and carrot seeds after drying can be obtained by physically extracting at 100 to 150 ° C in a compacted press heated. Or pulverized carrots or carrot seeds in an oil solvent such as caprylic / capric triglyceride for 3 to 24 hours, generally 3 to 12 hours, particularly 3 to 9 hours, It is possible. However, this method has a disadvantage in that it can not sufficiently extract the oil in carrots or carrots.

Next, organic solvent extraction is carried out by immersing the carrots before drying, carrots or carrot seeds after drying for 24 hours or longer by using hexane, methylene chloride, ethyl acetate, n-butanol, The components are extracted. However, such an organic solvent extraction method has a problem in that the organic solvent used must be separately removed.

Subsequently, the supercritical extraction method is a supercritical extraction method in which a supercritical fluid is applied at 25 to 40 DEG C under a pressure of 65 to 100 bar at a pressure of 250 to 800 bar at 35 to 90 DEG C, Followed by extraction. However, if it is out of the above range, the oil and the oil component may not be sufficiently extracted, or the extraction condition may become severe, and the overall extraction yield may be significantly lowered. Or by extracting the ground carrots or carrot seeds under the same conditions with an oil solvent such as caprylic / capric triglyceride by the supercritical extraction method after immersion for a predetermined time as mentioned above. Supercritical fluids used in the supercritical extraction method can be generally used supercritical fluids, but it is preferable to extract them using CO ₂ .

The phytosterol used in the moisturizing cosmetic composition for sensitive skin according to the present invention is also referred to as a plant sterol or a plant stanol and is structurally similar to the cholesterol produced in animals and has cholesterol Plant sterols are one of the essential constituents in plant cell membranes, as are essential ingredients, and typical phytosterols include beta-sitosterol, campesterol, and stigmasterol. Among these phytosterols, beta-sitosterol is known to have an anti-inflammatory effect in a mouse model of atopic dermatitis. However, the efficacy of beta-sitosterol for improving various symptoms of sensitive skin has not been elucidated.

The moisturizing cosmetic composition for sensitive skin according to the present invention may be a mixture of various phytosterol ingredients such as beta-sitosterol, campesterol, stigmasterol, or a single component. The above-mentioned phytosterol can be obtained by a method such as purification after extraction from a plant and is commercially available.

The carrot extract oil content is 0.5% to 50% by weight based on the total composition, the phytosterol ingredient is contained in an amount of 0.1 to 5% by weight based on the total composition, preferably 2 to 25% by weight of carrot extract oil, 0.5 to 3% If the amount is less than the above range, there is a possibility that the efficacy will be weak. If the above range is exceeded, it may cause a problem in formulation, which may not be desirable.

The moisturizing cosmetic composition for sensitive skin according to the present invention contains a mixture of ceramide, cholesterol and fatty acid as a skin lipid component, and a molar ratio of ceramide: cholesterol: fatty acid is 1: 1/3 to 3: 1/3 to 3, and specifically may be mixed in any one of 1: 1: 1, 3: 1: 1, 1: 3: 1, and 1: 1: 3. The content of the above mixture is 1 to 5% by weight based on the total weight of the composition. If it exceeds the above range, the skin barrier function may be weak or the formulation may be very difficult.

Since the ceramide, cholesterol and phytosterol components are generally a high-solubility substance, it is not easy to formulate cosmetic preparations, and after the formulation, recrystallization of these components, phase separation of the formulations and curing of the formulations may occur. Components are made into a liquid crystal emulsion form so as to have a regular arrangement of the lamellar liquid crystal structure at the emulsion interface.

In the present invention, the above-mentioned ceramide includes ceramide 3 which is acylated with phytosphingosine and ceramide 3B which is acylated with phytosphingosine and oleic acid, and the fatty acid is saturated or unsaturated, having 14 to 22 carbon atoms Contains unsaturated fatty acids.

In the present invention, the weakly acidic formulation capable of controlling the skin pH has a pH of 3.5 to 5.5. In other ranges, the pH adjustment may be slight or cause severe skin irritation.

Alpha hydroxy acid such as glycolic acid, lactic acid, malic acid, and citric acid is most suitable for controlling the pH. However, Not all ingredients that can give acidic pH can be used.

In the present invention, the liquid crystal emulsion formulation includes all of the carrot extract oil and phytosterol, the skin lipid component and the pH controlling ingredient, the nonionic emulsifier is used in an amount of 1.5 to 9.0% by weight based on the total composition, And may contain 1.0 to 5.0% as a reference, and exhibits a unique liquid crystal phase under a polarization microscope as shown in Fig.

Examples of nonionic emulsifiers based on the entire composition of 0.5 to 3.0% by weight glyceryl stearate weight, cetearyl olivate and / or sorbitan olivate 0.5 to 3.0% by weight as non-ionic emulsifier, C _{14- 22} alcohol and / or C _{12- 20} alkyl glucoside comprises from 0.5 to 3.0 wt%, or around the composition based on the weight of the glyceryl stearate 0.5 to 3.0 wt%, cetearyl olivate and / or sorbitan olivate 0.5 to 3.0 wt%, poly glyceryl stearate 0.5 to 3.0% by weight, include, or I based on composition 0.5 to 3.0% by weight glyceryl stearate, by weight, C _{14- 22} alcohol and / or C _{12- 20} alkyl glucoside 0.5 to 3.0 wt%, poly It may include glyceryl stearate 0.5 to 3.0% by weight, and a higher fatty alcohol before the fatty alcohols of C _16-24 as a single component or a mixed component crude Of water by weight it may contain from 3 to 5% by weight.

The moisturizing cosmetic composition for sensitive skin according to the present invention stably contains two components of carrot extract oil and high-fat-soluble phytosterol, which are insoluble components extracted from carrots, and the ceramide, cholesterol and phytosterol components are regularly And thus the carrot oil component is stably embedded in the liquid crystal emulsion, so that these components are very useful for effective skin transmission.

In addition, the moisturizing cosmetic composition for sensitive skin according to the present invention has a liquid crystal emulsion formulation containing carrot extract oil, a skin lipid component such as phytosterol component and ceramide, an alphahydroxy acid, a nonionic emulsifier, a high fat alcohol and the like , Various oils, thickeners, and other ingredients commonly used to make cosmetics such as creams and lotions may be added.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples, but the present invention is not limited thereto.

Example 1: Preparation of carrot extract oil

To prepare carrot extract oil, carrots purchased in Korea were hot-air dried and 250 g of dried carrots were finely pulverized by a pulverizer and mixed in a caprylic / capric triglyceride solvent at a ratio of 1: 3 and immersed for 6 hours. Subsequently, the supercritical carbon dioxide, which is a supercritical fluid, was added at a temperature of 40 ° C and a pressure of 300 bar to obtain a final carrot extract oil.

Test report of carrot extract oil Test Items standard result Exterior Clear, pale yellow liquid phase Pass incense Peculiarity Pass importance 0.910 to 0.918 0.912 Refractive index 1.460 to 1.480 1.470 Iodine value Up to 110 101 Marshmallow 180 ~ 200 191 heavy metal Less than 20 ppm Pass arsenic Less than 2 ppm Pass Ignition residue Less than 5% Pass

Example  2 to 4 and Comparative Example  1 to 3: Preparation of liquid crystal emulsion formulations

The composition components and the composition ratios of Examples 2 to 4 shown in the following Table 2 show typical examples of the liquid crystal emulsion formulations according to the present invention and contain carrot extract oil and phytosterol as main components and have skin lipids such as ceramide, And the base of the liquid crystal emulsion type may be changed depending on the kind of the nonionic emulsifier.

As Comparative Examples for Examples 2 to 4, Comparative Examples 1 to 3 were prepared by adding a small amount of a skin lipid component and adjusting the pH of the formulation to pH 6.0, which is similar to that of common cosmetics, without containing carrot extract oil and phytosterol. Instead of carrot extract oil, caprylic / capric triglyceride was replaced in equal amounts to match the total oil content

The degree of formation of the liquid crystal structure was confirmed to be very good (?), Good (?), Partially formed (?), Not formed (X).

As a result, it was observed that Examples 2 to 4 according to the present invention all formed a good liquid crystal structure, and some of Comparative Examples 1 to 3 were also formed.

In the following Examples and Comparative Examples, all raw materials corresponding to the oil phase were first put into an oil bath and melted while being heated at 80 to 90 ° C. Then, the raw materials corresponding to the water phase were added to the mixing bath and heated to 70 ° C, Was added to a mixing tank to be water-soluble and emulsified. After emulsification, the following ingredients were added to complete the formulation.

ingredient Example 2 Example 3 Example 4 Comparative Example 1 Comparative Example 2 Comparative Example 3 [Paid] Phytosterol 2.0 2.0 2.0 - - - Carrot extract oil 7.0 7.0 7.0 - - - Ceramide 3B, cholesterol, stearic acid mixture 2.5 2.5 - 0.5 0.5 - Ceramide 3, cholesterol, stearic acid mixture - - 2.5 - - 0.5 Cetearyl Olivate &
Sorbitan olivate 1.5 1.0 - 1.5 1.0 - C _{14- 22} alcohol &
C _{12- 20} alkyl glucoside 1.0 - 1.0 1.0 - 1.0 Polyglyceryl
Stearate - 1.5 1.5 - 1.5 1.5 Glyceryl stearate 1.5 1.5 1.5 1.5 1.5 1.5 Cetyl alcohol 2.0 2.0 2.0 2.0 2.0 2.0 Stearyl alcohol 2.0 2.0 2.0 2.0 2.0 2.0 Behenyl alcohol 0.5 0.5 0.5 0.5 0.5 0.5 Squalene 2.0 2.0 2.0 2.0 2.0 2.0 Macadamia seed oil 2.0 2.0 2.0 2.0 2.0 2.0 Caprylic / capric triglyceride 5.0 5.0 5.0 12.0 12.0 12.0 Tocopheryl acetate 0.5 0.5 0.5 0.5 0.5 0.5 [Awards] glycerin 7.0 7.0 7.0 7.0 7.0 7.0 Butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 Lactic acid seed 0.5 - 1.0 - - - Citric acid seed 0.5 1.0 - - - - Sodium lactate 0.5 - 1.0 0.5 - 1.0 Sodium citrate 0.5 1.0 - 0.5 1.0 - Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 Betaine 0.5 0.5 0.5 0.5 0.5 0.5 Arginine 0.5 0.5 0.5 0.5 0.5 0.5 Xanthan gum 0.2 0.2 0.2 0.2 0.2 0.2 Purified water Balance Balance Balance Balance Balance Balance [Attachment] antiseptic Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount Spices Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount pH 4.5 4.5 4.5 6.0 6.0 6.0 Degree of liquid crystal formation ◎ ◎ ◎ △ △ △

Example  5 to 9: Preparation of liquid crystal emulsion formulations

A liquid crystal emulsion formulation containing various contents of skin lipid components such as ceramide, cholesterol and fatty acid and phytosterol and having various pH was prepared at the composition and composition ratio shown in Table 3 below, and liquid crystal structures and formulations according to each liquid crystal emulsion base pH was observed.

As the content of lipids and phytosterol in skin increased, the formation of liquid crystal structure tended to decrease somewhat, but all showed good liquid crystal structure.

ingredient Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 [Paid] Phytosterol 1.0 3.0 1.0 3.0 1.0 3.0 Carrot extract oil 10.0 5.0 10.0 5.0 10.0 5.0 Ceramide 3B, cholesterol, stearic acid mixture 1.5 3.5 - - 1.5 3.5 Ceramide 3, cholesterol, stearic acid mixture - - 1.5 3.5 - - Cetearyl Olivate &
Sorbitan olivate 1.0 2.0 0.5 2.0 - - C _{14- 22} alcohol &
C _{12- 20} alkyl glucoside 1.0 3.0 - - 0.5 2.0 Polyglyceryl
Stearate - - 1.5 3.0 1.5 2.5 Glyceryl stearate 1.0 2.5 1.0 2.5 1.0 2.5 Cetyl alcohol 3.5 2.0 - 3.0 3.0 3.0 Stearyl alcohol - 3.0 3.5 2.5 - 2.0 Behenyl alcohol - 0.5 - 0.5 0.5 0.5 Squalene 2.0 2.0 2.0 2.0 2.0 2.0 Macadamia seed oil 2.0 2.0 2.0 2.0 2.0 2.0 Caprylic / capric triglyceride 2.0 7.0 2.0 7.0 2.0 7.0 Tocopheryl acetate 0.5 0.5 0.5 0.5 0.5 0.5 [Awards] glycerin 7.0 7.0 7.0 7.0 7.0 7.0 Butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 Lactic acid seed 0.5 0.5 - 0.5 - - Citric acid seed - 0.5 0.5 0.5 0.5 1.0 Sodium lactate 0.5 0.5 - 0.5 - - Sodium citrate - 0.5 1.0 0.5 0.5 1.0 Disodium iodide 0.02 0.02 0.02 0.02 0.02 0.02 Betaine 0.5 0.5 0.5 0.5 0.3 0.5 Arginine 0.5 - 1.0 0.5 0.3 - Xanthan gum 0.2 0.2 0.2 0.2 0.2 0.2 Purified water Balance Balance Balance Balance Balance Balance [Attachment] antiseptic Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount Spices Proper amount Proper amount Proper amount Proper amount Proper amount Proper amount pH 5.0 4.0 5.5 4.5 5.0 4.0 Degree of liquid crystal formation ◎ ○ ◎ ○ ◎ ○

Experimental Example: Clinical Evaluation of Sensitive Skin

In order to confirm the efficacy of skin barrier function, skin moisturizing, erythema and subjective symptoms, 30 patients diagnosed as Rosacea, which is the representative disease that appeals to sensitive skin among patients over 18 years old who complain of symmetric erythema on the face, Of the study population.

The participants of the clinical trial were cleaned their faces by using a mild detergent in the morning and evening, and one side of the face was coated with the cosmetic material of Example 2 in Table 2 above, and the other side was coated with Comparative Example 1 twice daily Respectively. In addition to the test cosmetics, the use of other topical medicines was prohibited, and the subjects were not using or minimizing the cosmetics they already used.

Experimental Example  One : Skin barrier function  Improvement effect

To evaluate the effect of moisturizing cosmetics on skin barrier function, changes of TEWL and skin moisture contents were measured by TEWA meter and Corneometer, respectively.

Item sample Before use after use Rate of change Basal TEWL Example 2 13.66 + - 4.73 10.71 + - 4.45 22% Comparative Example 1 13.32 ± 4.10 12.82 ± 4.09 3.7% Skin Hydration Example 2 53.39 + - 7.25 63.83 + - 6.88 20% Comparative Example 1 53.00 ± 7.92 52.62 ± 8.97 - 0.1%

As a result, as shown in Table 4, it was confirmed that Example 2 significantly decreased the TEWL and significantly increased the skin hydration of the skin surface. Since the basal TEWL is not high and the water content value is not low in the case of the main type skin, unlike the atopic skin, the above rate of change after 2 weeks of use is considered to be a significant change in the main type skin. In addition, in the case of atopic skin, since basal TEWL is high and water content value is low, it is expected that the use of the cosmetic material according to the present invention will further increase the difference. Thus, it was confirmed that the cosmetic composition according to Example 2 can improve skin barrier function in sensitive skin.

Experimental Example  2: Improvement of skin erythema

In order to confirm the skin erythema improvement effect of the moisturizing cosmetic composition, the clinical pictures were taken under the same condition using the skin image analysis system (DermaVision) after the first visit and two weeks after the clinical study, and the obtained clinical pictures were analyzed using the analysis program The Erythema index was compared and evaluated.

Item sample Before use after use Rate of change Erythema index Example 2 363.79 + - 71.43 330.17 + - 68.36 9.2% Comparative Example 1 367.38 ± 79.99 357.41 + - 79.43 2.7%

As a result, as shown in Table 5, Example 2 showed significant improvement of about 10% after 2 weeks of use. The significant difference between before and after use of Example 2 was found to be p = 0.001, and a significant difference from that of Comparative Example 1 was found to be p = 0.02. Erythema, and redness symptoms.

Experimental Example  3: Skin pH improvement effect

Skin surface pH was measured using a SenTix Sur electrode and a Vario pH meter to confirm the effect of improving the skin pH of the moisturizing cosmetic composition.

Item sample Before use after use Rate of change Skin pH Example 2 5.20 0.35 4.78 0.41 8.1% Comparative Example 1 5.15 ± 0.37 5.14 ± 0.33 0.2%

As a result, as shown in Table 6, Example 2 showed a significant improvement of about 10% after 2 weeks of use. This indicates that the significant difference between Example 1 and Example 2 was p = 0.002, and the significant difference from Comparative Example 1 was p = 0.05, and it was confirmed that the cosmetic composition of Example 2 had a sensitivity It was confirmed that the skin pH could be improved in the skin.

Experimental Example  4: Improvement of Subjective Subjective Symptoms

The visual analogue scale (VAS) was assessed with a score ranging from 0 (no discomfort) to 10 (unbearable discomfort) for the subjective subjective symptoms of the subject, such as itching, tingling and burning of the skin. The results of the questionnaires were evaluated to see if the improvements were effective.

Item sample Before use after use Rate of change VAS Example 2 4.5 ± 1.82 2.3 ± 1.97 49% Comparative Example 1 4.3 ± 1.95 3.8 ± 1.94 12%

As a result, as shown in Table 7, Example 2 showed significant improvement of about 50% of subjective symptoms such as itching, tingling and burning after 2 weeks of use. Therefore, it was confirmed that the cosmetic composition of Example 2 can also improve subjective irritation symptoms in sensitive skin.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. Various changes and modifications can be made by those skilled in the art without departing from the spirit and scope of the invention Which is also within the scope of the present invention.

Claims (5)

A moisturizing cosmetic composition for sensitive skin comprising a weakly acidic liquid crystal emulsifying composition comprising as an active ingredient for improving sensitive skin symptoms, carrot extract oil and phytosterol as main components and a skin lipid component for improving skin barrier function as an auxiliary ingredient. [3] The composition according to claim 1, wherein the carrot extract oil comprises 0.5 to 50% by weight of the total composition, and 0.1 to 5% by weight of the total composition of phytosterol. The composition according to claim 1, wherein the skin lipid component for improving skin barrier function is a mixture of ceramide, cholesterol and fatty acid, the mixture contains 1 to 5% by weight based on the total composition and the pH of the formulation is 3.5 to 5.5 Moisturizing cosmetic composition for sensitive skin. The composition according to claim 1, wherein the liquid crystal emulsion is a nonionic emulsifier containing 0.5 to 3.0% by weight of glyceryl stearate, 0.5 to 3.0% by weight of cetearyl olivate or sorbitan olivate, _14-22 include alcohol or C _{12- 20} alkyl glucoside 0.5 to 3.0 wt%, or around the reference composition to 0.5 to 3.0% by weight glyceryl stearate weight, cetearyl olivate or sorbitan olivate 0.5 to 3.0% by weight , polyglyceryl stearate 0.5 and including 3.0 wt%, or around the composition based on the weight of the glyceryl stearate 0.5 to 3.0 wt%, C _{14- 22} alcohol or C _{12- 20} alkyl glucoside 0.5 to 3.0 wt%, poly 0.5 to 3.0% by weight of glyceryl stearate; _Wherein the composition comprises 3 to 5% by weight of a fatty alcohol of C _16-24 as a high-fat alcohol based on the weight of the composition. The method according to claim 1, wherein the sensitized skin symptom is at least one of subjective symptoms of itching, burning, stinging or pulling, appearance symptoms of erythema, flushing, keratin, or drying, atopic dermatitis, seborrheic dermatitis, A moisturizing cosmetic composition for sensitive skin, which is an allergic contact dermatitis or rosacea dermatitis symptom.

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