KR101015909B1 - Cosmetic composition for skin external application containing chia oil - Google Patents

Abstract

The present invention relates to an external skin cosmetic composition comprising chia seed oil and pseudoceramide, and more particularly, to an external skin cosmetic composition containing 1 to 10% by weight of chia seed oil and 0.1 to 10% by weight of pseudoceramide. The cosmetic composition for external skin of the present invention has excellent skin moisture retention ability and has an excellent effect on the prevention and improvement of dry skin accompanied by atopic dermatitis, contact dermatitis, childhood, chronic eczema, psoriasis, chronic renal failure, pruritus seen in diabetes mellitus Can be used as an adjunct moisturizer for dry skin with dryness.

Chia seed oil, pseudoceramide, pruritus, moisturizing

Description

Cosmetic composition for skin external containing chia seed oil {{Cosmetic composition for skin external application containing chia oil}

The present invention relates to a cosmetic composition for external skin containing chia seed oil, and more particularly to a cosmetic composition for external skin having chia seed oil and pseudoceramide as an active ingredient, having an excellent skin moisturizing effect and pruritus relief effect.

The health of the skin is influenced by environmental factors such as climate, season, ultraviolet rays, and endogenous factors such as heredity, aging, hormones, stress, and nutritional status. Decrease results in increased evaporation and infection of the epidermis, resulting in increased dryness, hyperproliferation, inflammation and pruritus. The epidermis of psoriasis or atopic dermatitis disease in which the sebaceous membrane is damaged has been reported to have decreased ceramide levels. It is known that the ceramide level of the epidermis decreases.

Pruritus is an unpleasant sensation of the skin you want to scratch, a secondary symptom in a wide range of skin diseases, from dry skin to malignant cancer. In general, diabetes, jaundice, thyroid disease, pregnancy, side effects of drugs, infectious diseases, contact dermatitis and the like cause of skin itching. In many cases, pruritus is also accompanied by dry skin. If you do not scratch and scratch the itch, rashes or swelling in the area is easy to worsen symptoms, so pruritus relief is important.

Dry skin refers to a condition in which the skin lacks or lacks moisture (about 10% or less), and clinically defined skin refers to a skin condition with a slight erythema and cracks, with a sulphated and rough surface. Skin diseases related to dry skin include atopic dermatitis, young children, chronic eczema and psoriasis, and dry skin is also called in patients with chronic renal failure and diabetics, and lymphoma, liver disease, thyroid disease, and central nervous system. It also occurs in association with infarction. In addition, elderly people aged 65 years or older are accompanied by dry skin without any obvious disease.

The main cause of dry skin is the damage to the stratum corneum in the outermost part of the skin. The skin primarily serves as a physical barrier at the interface between the external environment and the human body and protects the human body from dry environments and mechanical, chemical stimuli or microorganisms. The keratinocytes in the skin, in the basal layer, which is the lowest layer of the epidermis, rise to the skin surface through the polar layer and the granule layer, and produce natural moisturizing factors and intercellular lipids to function as skin barriers.

In relation to the conventional skin drying and alleviation of pruritus, Korean Patent Laid-Open Publication No. 2008-004305 discloses a dietary composition for inhibiting ceramide reduction, comprising fermentation extracts of three hundred vinegar, eocho vinegar and porcelain mixture. Korean Patent No. 076730 discloses' Trichosanthes kirilowii Maxim, Cinnamon cortex (Cinnamon bark), Angelica Gigantis Radix, Asari Herba, Japanese knotweed and Clove (Caryophylli Flos). Disclosed is a skin external pharmaceutical composition for the treatment and improvement of wound healing and pruritus containing a complex herbal extract comprising a.

Drying of the skin and pruritus are typical symptoms of various skin diseases, and various moisturizers have been used as adjuvant treatments for atopic dermatitis, contact dermatitis, young, chronic eczema, psoriasis, chronic renal failure, and diabetes related to skin drying. However, there has been a need for the development of a variety of new materials with therapeutic efficacy for these symptoms.

The present inventors have recognized the above problems and continued the study, and found that an external skin cosmetic composition containing chia seed oil and pseudoceramide as an active ingredient is effective in preventing and improving dry skin with pruritus. Was completed.

Accordingly, it is an object of the present invention to provide an external skin cosmetic composition having excellent skin moisturizing effect.

Another object of the present invention is to provide an external skin cosmetic composition for alleviating skin pruritus.

Still another object of the present invention is to provide a cosmetic composition for external skin that exhibits a wound improvement and soothing effect.

According to one embodiment of the present invention for achieving the above object, 1 to 10% by weight, preferably 2 to 6% by weight of chia seed oil, 1 selected from the group consisting of the compounds of formulas (I) and (II) An external skin cosmetic composition containing 0.1 to 10% by weight, preferably 0.4 to 2.0% by weight, of at least one kind of pseudoceramide is provided.

R ₁ -COCHR ₂ CONR ₃ R ₄ (Ⅰ)

R ₁ -CH (OH) CHR ₂ CONR ₃ R ₄ (II)

(Wherein R ₁ And R ₂ each represents a straight or branched alkyl group having 6 to ₂₂ carbon atoms, or an alkenyl group; R ₃ And R ₄ is H, CH ₃ , C ₂ H ₅ , C ₃ H ₇ , or a straight or branched alkyl group or monosaccharide having 2 to 6 carbon atoms having one or more hydroxy groups)

According to another embodiment of the present invention for achieving the above object, 0.1 to 10% by weight of tocopheryl acetate, preferably 0.5 to 3% by weight and 0.1 to 10% by weight of panthenol, preferably 0.5 to the external skin cosmetic composition There is provided a cosmetic composition for external skin, which further contains -5% by weight.

According to another embodiment of the present invention for achieving the above object, in the skin external cosmetic composition, a skin external cosmetic composition, characterized in that the weight ratio of chia seed oil: tocopheryl acetate: pseudoceramide is 4: 2: 1. This is provided.

The external skin cosmetic composition is characterized in that the external skin composition for the prevention and improvement of skin dryness with pruritus. The external skin cosmetic composition is characterized in that the external skin composition for the prevention and improvement of skin dryness accompanied by atopic dermatitis, contact dermatitis, young, chronic eczema, psoriasis, chronic renal failure, pruritus seen in diabetes. The skin external cosmetic composition is characterized in that the preparation of creams, lotions, ointments and the like.

Chia Seed is a natural plant rich in linolenic acid and contains seven times more omega-3 fatty acids than Atlantic salmon and consists of various amino acids, vitamins and dietary fiber. It also contains no toxic substances and is used in various foods. Chia seed oil used in the present invention contains 17 to 26% linoleic acids and 50 to 75% linolenic acids, which are a type of omega-3 fatty acid.

The position of the first carbon double bond attached to the methyl end group of the fatty acid in the lipid molecule is very important for the metabolism and classification of lipids. N-3 type (ω3 type) fatty acid when the first double bond appears from the methyl group to the 3rd carbon, n-6 type (ω6 type) fatty acid when the 6th carbon appears, and n-9 type (ω9 type) fatty acid This is called. Omega-9 fatty acids are synthesized in the body, but omega-3 and omega-6 fatty acids are not synthesized in the body because there is no unsaturated enzyme in the body that creates a double bond at that position.

Omega 3 fatty acids include ALA (alpha Linolenic acid, C18: 3), EPA (Eicosapentaenoic acid, C20: 5), DPA (Docosapentaenoic acid, C22: 5), DHA (Docosahexaenoic acid, C22: 6), SDA (stearidonic acid, 18: 4).

Polyunsaturated fatty acids (PUFAs) and their metabolites are known to affect the incidence and extent of allergic diseases because they have the ability to modulate immune function. Omega-3 fatty acids have an anti-inflammatory effect, which is due to the inhibition of the release of arachidonic acid (AA) from the phospholipids of the cell membrane, resulting in a decrease in the production of proinflammatory eicosanoids. Journal, 2006) The intake of omega-3 fatty acids such as EPA and DHA was significantly lower in patients with atopic dermatitis (Manku MS, Br J Dermatol, 1984) (Biagi PL, Acta Pediatr, 1993). Higher levels have lowered the incidence of atopic disease (Negel G, Allergy, 2003). Omega-3 fatty acids also inhibit the production of prostaglandins, which cause asthma and rheumatoid arthritis.

The pseudoceramide used in the present invention uses those disclosed in Korean Patent No. 10-0472125 and US Patent No. 06221371 of the present applicant, and the structure thereof is as follows. The following formula (I) is synthesized by reacting an alkyl ketenedimer with ethanolamine, and the following formula (II) is prepared by reduction reaction of formula (I).

R ₁ COCHR ₂ CONR ₃ R ₄ (Ⅰ)

R ₁ CH (OH) CHR ₂ CONR ₃ R ₄ (II)

(Wherein, R ₁ And R ₂ each represents a straight or branched alkyl group having 6 to ₂₂ carbon atoms, or an alkenyl group; R ₃ And R ₄ is H, CH ₃ , C ₂ H ₅ , C ₃ H ₇ , or a straight or branched alkyl group or monosaccharide having 2 to 6 carbon atoms having one or more hydroxy groups)

In particular in formula (I) and formula (II), the -NR ₃ R ₄ moiety is -NHCH ₂ CH (OH) CH ₂ OH, -NHCH (CH ₂ OH) ₂ , -NHCH ₂ (CH (OH)) ₄ Preference is given to CH ₂ OH, —NHC (CH ₃ ) (CH ₂ OH) ₂ , —NHCH ₂ CH ₂ OH.

The pseudoceramide used in the present invention has a structure similar to lipids between keratinocytes in the skin and thus exhibits a skin moisturizing effect, thereby contributing to the stabilization of the active ingredient of the skin cosmetic composition of the present invention by forming a multilamellar structure in the skin. Done. Therefore, it keeps active for a long time and acts on the skin.

Tocopheryl acetate used in the present invention is excellent in moisturizing and antioxidant effects when applied to the skin.

Panthenol used in the present invention promotes cell division and persistence of collagen fibers to help improve wounds, and has an excellent soothing and moisturizing effect.

The cosmetic composition for external skin of the present invention is 1 to 10% by weight of chia seed oil, preferably 2 to 6% by weight, and 0.1 to 10% by weight of one or more pseudoceramides selected from the group consisting of the compounds of Formulas (I) and (II). %, Preferably 0.4 to 2.0% by weight, and 0.1 to 10% by weight of tocopheryl acetate, preferably 0.5 to 3% by weight and 0.1 to 10% by weight of panthenol, preferably 0.5 to If it contains 5% by weight, it has an antioxidant effect, wound improvement, and skin soothing effect in addition to skin moisturizing and pruritus alleviating effect.

When the active ingredient is contained in the cosmetic composition for external skin of the present invention less than the content, the effect is insignificant, there is an economic problem when the content exceeds.

In addition, in the external skin cosmetic composition of the present invention, when the weight ratio of the chia seed oil: tocopheryl acetate: pseudoceramide is 4: 2: 1, it shows a more balanced effect.

The skin moisturizer according to the present invention has an excellent effect on the prevention and improvement of dry skin accompanied by atopic dermatitis, contact dermatitis, young children, chronic eczema, psoriasis, chronic renal failure, pruritus seen in diabetes mellitus, and can be used as an adjuvant treatment of the above diseases. Can be.

The composition of the skin moisturizer for improving dry skin with pruritus of the present invention is not particularly limited in its formulation, and may be prepared, for example, in the form of a cream, lotion or ointment. In addition, in the composition of each humectant, components other than chia seed oil, pseudoceramide, tocopheryl acetate, and panthenol may be selected and blended according to the formulation or purpose of other external preparations.

As described above, the external skin cosmetic composition according to the present invention is excellent in skin moisture retention ability, prevention of skin dryness accompanied by pruritus seen in atopic dermatitis, contact dermatitis, young, chronic eczema, psoriasis, chronic renal failure, diabetes, etc. And it has an excellent effect on improvement can be used as an adjuvant treatment of the disease.

Hereinafter, the present invention will be described in detail by the following Examples and Test Examples. However, the following examples and the like are only intended to illustrate the present invention, the present invention is not limited by the following examples.

Example 1 Cream Preparation

To prepare a cream having a composition as shown in Table 1. An aqueous component and methyl paraoxybenzoate were added to purified water, and the mixture was heated and adjusted to 70 ° C.

And oil component (similar ceramide is R ₁ And R ₂ is a straight chain alkyl group having 14 carbon atoms, -NR ₃ R ₄ is -NHCH ₂ CH ₂ OH) was dissolved and heated to add a paraoxybenzoic acid profile and adjusted to 70 ℃. This was added to the previous water phase, emulsified with a homomixer, and then cooled, degassed, and filtered.

TABLE 1

function ingredient Content (% by weight) Paid Chia seed oil
Pseudoceramide 4.0
1.0 Cetostearyl alcohol
Squalane
Tocopheryl acetate 4.0
4.0
2.0 POE (10) Glyceryl Monostearate
Glyceryl Stearate 1.5
1.5 Awards glycerin
Xanthan Gum
Panthenol
Purified water 5.0
0.1
0.5
Remaining amount Other Ingredients Methyl paraoxybenzoate
Paraoxybenzoic Acid Profiles Suitable amount
Suitable amount

Example 2 Lotion Preparation

To prepare a lotion having a composition as shown in Table 2. An aqueous component and methyl paraoxybenzoate were added to the purified water, and the mixture was heated and adjusted to 70 ° C.

And oil component (similar ceramide is R ₁ And R ₂ is a straight chain alkyl group having 14 carbon atoms, -NR ₃ R ₄ is -NHCH ₂ CH ₂ OH) was dissolved and heated to add a paraoxybenzoic acid profile and adjusted to 70 ℃. This was added to the previous water phase, emulsified with a homomixer, and then cooled, degassed, and filtered.

TABLE 2

function ingredient Content (% by weight) Paid Chia seed oil
Pseudoceramide 4.0
1.0 Cetostearyl alcohol
Squalane
Tocopheryl acetate 1.0
3.0
2.0 POE (10) Glyceryl Monostearate
Glyceryl Stearate 1.0
1.0 Awards glycerin
Xanthan Gum
Panthenol
Purified water 5.0
0.1
0.5
Remaining amount Other Ingredients Methyl paraoxybenzoate
Paraoxybenzoic Acid Profiles A reasonable amount
A reasonable amount

Example 3 Ointment Preparation

An ointment having the composition shown in Table 3 below was prepared. An aqueous component and methyl paraoxybenzoate were added to the purified water, and the mixture was heated and adjusted to 70 ° C.

And oil component (similar ceramide is R ₁ And R ₂ is a straight chain alkyl group having 14 carbon atoms, -NR ₃ R ₄ is -NHCH ₂ CH ₂ OH) was dissolved and heated to add a paraoxybenzoic acid profile and adjusted to 70 ℃. It was mixed homogeneously with a homomixer and then cooled, degassed and filtered.

[Table 3]

function ingredient content(%) Paid Chia seed oil
Pseudoceramide 4.0
1.0 Petrolatium
Cetostearyl alcohol
Hard flow paraffin
Tocopheryl acetate Suitable amount
3.0
5.0
2.0 Seteareth-20 3.0 Awards Panthenol
Purified water 0.5
Remaining amount Other Ingredients Panthenol
Methyl paraoxybenzoate
Paraoxybenzoic Acid Profiles 0.5
A reasonable amount
A reasonable amount

Example 4 Preparation of Cream without Tocopheryl Acetate and Panthenol

To prepare a cream having a composition as shown in Table 4. An aqueous component and methyl paraoxybenzoate were added to the purified water, and the mixture was heated and adjusted to 70 ° C.

And oil component (similar ceramide is R ₁ And R ₂ is a straight chain alkyl group having 14 carbon atoms, -NR ₃ R ₄ is -NHCH ₂ CH ₂ OH) was dissolved and heated to add a paraoxybenzoic acid profile and adjusted to 70 ℃. This was added to the previous water phase, emulsified with a homomixer, and then cooled, degassed, and filtered.

[Table 4]

function ingredient Content (% by weight) Paid Chia seed oil
Pseudoceramide 4.0
1.0 Cetostearyl alcohol
Squalane 4.0
4.0 POE (10) Glyceryl Monostearate
Glyceryl Stearate 1.5
1.5 Awards glycerin
Xanthan Gum
Purified water 5.0
0.1
Remaining amount Other Ingredients Methyl paraoxybenzoate
Paraoxybenzoic Acid Profiles Suitable amount
Suitable amount

Comparative Example 1 Cream Without Chia Seed Oil

Except that the chia seed oil is not included in the oil phase component in Example 1 was prepared in the same manner as in Example 1 shown in Table 5 below.

<Comparative Example 2> Cream containing no pseudoceramide

Except that the pseudo ceramide is not included in the oil phase component in Example 1 was prepared in the same manner as in Example 1, the composition of Table 5 below.

TABLE 5

function ingredient Comparative Example 1
(weight%) Comparative Example 2
(weight%) Dairy ingredients Chia seed oil
Pseudoceramide -
1.0 4.0
- Hard flow paraffin 4.0 1.0 Cetostearyl alcohol
Squalane
Tocopheryl acetate 4.0
4.0
2.0 4.0
4.0
2.0 Emulsifier POE (10) Glyceryl Monostearate
Glyceryl Stearate 1.5
1.5 1.5
1.5 Moisturizer glycerin
Xanthan Gum
Panthenol 5.0
0.1
0.5 5.0
0.1
0.5 antiseptic Methyl paraoxybenzoate
Paraoxybenzoic Acid Profiles A reasonable amount
A reasonable amount A reasonable amount
A reasonable amount Etc Purified water Balance Balance

<Test Example 1> skin function improvement effect

Twelve people with dry skin with pruritus were measured for transdermal moisture evaporation inside the upper arm of both arms and water content in the stratum corneum of the skin. Each was analyzed using a moisture evaporation meter (Tewameter, TM300, Courage-Khazaka Electronic GmbH, Germany) and a skin moisture meter (Corneometer, CM825, Courage-Khazaka Electronic GmbH, Germany). In order to induce acute skin barrier damage, tape stripping was repeatedly performed using D-Squame tape (Cu-Derm Corporation, Dallas, USA) at the same site. After acute skin barrier damage, the creams of Example 1, Comparative Example 1 and Comparative Example 2 were immediately applied to each of the three areas of the damaged skin, and then applied once a day to change the function of the skin over time. Evaluated. Changes in transdermal moisture loss and moisture content in the stratum corneum were measured after 3 hours, 6 hours, 12 hours, 24 hours, 48 hours, and 120 hours, respectively. Calculated using the same formula.

Change of skin hydration = Skin hydration at measured time-Skin hydration before barrier disruption

Recovery rate of transdermal moisture loss (% Recovery of TEWL) = [1- (TEWL measurement after a certain time-TEWL measurement before skin barrier damage) / (TEWL measurement immediately after skin barrier damage-TEWL measurement before skin barrier damage) X 100

Changes in moisture content and transdermal moisture recovery in the stratum corneum after acute skin barrier injury tended to recover most rapidly in Example 1 containing chia seed oil, pseudoceramide, tocopheryl acetate and panthenol, and containing chia seed oil and pseudoceramide. And Example 4 containing no tocopheryl acetate and panthenol showed a second tendency to recover. As a result, it was confirmed that the use of chia seed oil and pseudo ceramide in combination with chia seed oil and pseudo ceramide alone may have a superior skin function improvement effect.

Changes in moisture content in the stratum corneum after acute skin barrier injury are shown in Table 6 and FIG. 1, and the results of the measurement of the recovery rate of transdermal moisture loss after acute skin barrier injury are shown in Table 7 and FIG. 2.

[Table 6] SC hydration average value

sample Before application
medium After application
Measured average value Before damage Immediately after 3 hours 6 hours 24 hours 48 hours 120 hours Example 1 57.50
(± 2.64) 41.50
(± 0.58) 47.00
(± 1.41) 51.00
(± 1.15) 59.50
(± 1.29) 58.75
(± 1.89) 58.25
(± 2.75) Example 4 57.75
(± 2.75) 41.50
(± 1.41) 46.00
(± 1.29) 49.50
(± 1.73) 59.00
(± 2.16) 58.70
(± 1.41) 58.00
(± 0.58) Comparative Example 1 58.00
(± 3.16) 41.50
(± 1.29) 45.50
(± 0.58) 47.75
(± 1.71) 58.50
(± 1.29) 58.50
(± 1.73) 58.00
(± 3.16) Comparative Example 2 27.50
(± 6.14) 41.25
(± 1.71) 45.25
(± 0.96) 47.25
(± 1.50) 58.25
(± 3.86) 57.50
(± 7.23) 57.50
(± 6.14)

[Table 7] TEWL average value

sample Before application
medium After application
Measured average value Before damage Immediately after 3 hours 6 hours 24 hours 48 hours 120 hours Example 1 18.00
(± 1.83) 46.25
(± 1.25) 34.00
(± 2.71) 29.25
(± 0.96) 21.50
(± 0.58) 19.00
(± 1.41) 18.00
(± 1.83) Example 4 18.25
(± 1.41) 46.25
(± 0.58) 35.00
(± 2.75) 30.25
(± 0.58) 22.00
(± 1.29) 19.50
(± 1.75) 18.25
(± 1.41) Comparative Example 1 18.75
(± 2.22) 46.50
(± 2.65) 37.50
(± 2.38) 33.25
(± 1.89) 24.50
(± 1.29) 21.50
(± 1.91) 19.00
(± 2.58) Comparative Example 2 18.50
(± 2.08) 45.75
(± 3.59) 37.00
(± 2.83) 32.50
(± 2.38) 24.00
(± 2.16) 20.00
(± 1.63) 18.50
(± 2.08)

<Test Example 2> Clinical Evaluation

Five patients with dry skin symptoms accompanied by pruritus among the diabetic or chronic renal failure patients attending Korea University Hospital Dermatology, Renal Medicine and Endocrine Medicine from December 2007 to March 2008 with the cream obtained as a result of Example 1; A clinical evaluation was conducted for 8 weeks with 5 general people with dry skin with pruritus.

Evaluation of skin improvement (transdermal moisture evaporation and skin moisture content)

The experimental method is as follows.

For eight weeks, other treatments besides the cream containing chia seed oil and pseudoceramide were inhibited, and the cream formulation obtained as a result of Example 1 was given and applied whenever an unpleasant symptom such as pruritus occurs. Transdermal moisture evaporation and moisture content in the stratum corneum were measured at constant temperature and humidity conditions (temperature 23 ± 1 ℃, humidity 50 ± 2%) before, 2, 4, 6, and 8 weeks after the start of application. The evaporation rate was measured using a water evaporator Evaporimeter EPI (sEVOmED, Stockholm, Sweden), and the moisture content of the skin was measured using a skin moisture meter (Corneometer CM-820, Courage-Khazaka Electronic GmbH, Germany).

The results are shown in Table 8 below.

[Table 8]

Item division 0 week 2 weeks 4 weeks 6 weeks 8 weeks Percutaneous moisture evaporation patient 9.78
(± 4.44) 7.75
(± 1.58) 9.13
(± 9.13) 6.98
(± 1.48) 6.54
(± 2.35) Public 10.94
(± 8.76) 6.11
(± 1.05) 7.85
(± 5.80) 4.83
(± 0.13) 6.44
(± 2.13) Skin moisture content patient 26.00
(± 12.20) 32.60
(± 12.33) 38.93
(± 4.66) 38.20
(± 7.57) 40.13
(± 2.13) Public 30.86
(± 3.90) 29.50
(± 6.83) 28.53
(± 4.32) 25.67
(± 0.33) 30.06
(± 4.39)

As confirmed in Table 8, in the case of the external preparation for skin prepared with the composition according to the present invention, both the patient and the general public can see that the amount of transdermal moisture evaporation decreases. The moisture content of the skin was almost unchanged after 8 weeks in the general public, but the skin moisture content was increased in the patient.

Subjective evaluation

The experimental method is as follows.

For eight weeks, other treatments besides creams containing chia seed oil and pseudoceramide were inhibited and the cream formulations obtained as a result of Example 1 were given and applied whenever an unpleasant symptom such as pruritus occurs. Subjective evaluation was conducted every two weeks after the start of application. The items consisted of 6 items: satisfaction, dryness improvement, itching improvement, scratches (scratch wounds) improvement, chronic simple salivary gland (itchy and thickened eczema) improvement, and crystalline pruritus improvement. , worse; 1, almost no change; 2, medium; 3, improvement; 4, satisfied; 5, 6 grades of healing were classified and evaluated. The results are shown in Table 9 below and FIGS. 3 to 5.

TABLE 9

Item division 2 weeks 4 weeks 6 weeks 8 weeks satisfaction patient 2.0
(± 0) 2.8
(± 0.97) 2.8
(± 0.97) 2.8
(± 0.97) Public 3.0
(± 1.0) 4.0
(± 0) 4.0
(± 0) 4.25
(± 0.43) Dryness
Improvement patient 1.8
(± 0.97) 3.0
(± 0) 3.0
(± 0) 3.0
(± 0) Public 3.0
(± 0) 3.4
(± 0.8) 3.4
(± 0.8) 3.4
(± 0.8) Itching
Improvement patient 1.4
(± 0.8) 2.2
(± 0.97) 2.2
(± 0.97) 2.2
(± 0.97) Public 2.2
(± 0.97) 2.2
(± 0.97) 2.6
(± 0.8) 3.0
(± 1.2) abrasion
Improvement patient 1.4
(± 0.8) 1.8
(± 0.97) 1.8
(± 0.97) 1.8
(± 0.97) Public 2.2
(± 0.97) 2.6
(± 0.8) 2.6
(± 0.8) 2.6
(± 0.8) Chronic simple glandular improvement patient 1.0
(± 0) 1.8
(± 0.97) 2.0
(± 1.26) 3.0
(± 0) Public 2.2
(± 0.97) 2.2
(± 0.97) 2.2
(± 0.97) 2.6
(± 0.8) Crystalline Pruritus Improvement patient 1.0
(± 0) 1.4
(± 0.8) 1.6
(± 1.2) 2.2
(± 0.97) Public - - - -

As shown in Figures 3 to 5 and Table 9, in the case of the external preparation for skin prepared by the composition according to the present invention both the patient and the general public showed an improvement effect in all items, especially in the case of dryness accompanied by pruritus It was confirmed that there was a great possibility, and no side effects were reported.

1 is a graph showing a change in the water content in the stratum corneum after acute skin barrier damage when the external application composition for skin according to an embodiment of the present invention is applied.

2 is a graph showing the results of measuring the recovery rate of transdermal moisture loss after acute skin barrier injury when the external application composition for skin according to an embodiment of the present invention is applied.

3 and 4 are clinical photographs of patients with diabetes or renal failure according to the present invention before and after clinical evaluation for 8 weeks.

Figure 5 is a clinical picture of the general public with dry skin symptoms with pruritus of the present invention before and after the clinical evaluation for 8 weeks.

Claims (5)

A skin external cosmetic composition containing 1 to 10% by weight of chia seed oil and 0.1 to 10% by weight of one or more pseudoceramides selected from the group consisting of the compounds of formulas (I) and (II). R ₁ -COCHR ₂ CONR ₃ R ₄ (Ⅰ) R ₁ -CH (OH) CHR ₂ CONR ₃ R ₄ (II) (Wherein R ₁ and R ₂ are each a linear or branched alkyl group having 6 to ₂₂ carbon atoms or an alkenyl group; R ₃ and R ₄ are each H, CH ₃ , C ₂ H ₅ , C ₃ H ₇ , or C2-C6 straight or branched alkyl group or monosaccharide having one or more hydroxy groups) The skin cosmetic composition according to claim 1, further comprising 0.1 to 10% by weight of tocopheryl acetate and 0.1 to 10% by weight of panthenol. According to claim 2, wherein the skin seed cosmetic composition, characterized in that the weight ratio of chia seed oil: tocopheryl acetate: pseudoceramide is 4: 2: 1. The composition according to any one of claims 1 to 3, wherein the composition is used for the prevention and amelioration of dry skin with atopic dermatitis, contact dermatitis, young, chronic eczema, psoriasis, chronic renal failure, pruritus seen in diabetes mellitus. Cosmetic composition for external skin, characterized in that it becomes. The skin cosmetic composition according to any one of claims 1 to 3, wherein the composition is a cream, lotion, or ointment preparation.

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