CN115040438B

CN115040438B - Skin composition for promoting skin barrier repair function, preparation method and application thereof

Info

Publication number: CN115040438B
Application number: CN202210760279.8A
Authority: CN
Inventors: 崔英云; 李传茂; 张伟杰; 张楚标; 曾伟丹
Original assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Current assignee: Guangdong Danz Group Co Ltd; Guangzhou Keneng Cosmetic Research Co Ltd
Priority date: 2022-06-29
Filing date: 2022-06-29
Publication date: 2023-12-15
Anticipated expiration: 2042-06-29
Also published as: CN115040438A

Abstract

The application provides a skin composition for promoting skin barrier repair function, a preparation method and application thereof. The skin composition comprises an active ingredient in an amount of 0.021-50%, preferably 0.1-25%, more preferably 0.5-10% based on 100% of the total mass of the skin composition; wherein the active ingredients comprise chia seed oil, sunflower seed oil unsaponifiable matter and ceramide. The skin composition for promoting the skin barrier repairing function has the effects of calming and relieving, resisting bacteria and inflammation, resisting oxidation, resisting ultraviolet and infrared radiation and repairing skin injury, and achieves the effects of enhancing skin resistance, maintaining skin health and stability and relieving skin discomfort.

Description

Skin composition for promoting skin barrier repair function, preparation method and application thereof

Technical Field

The application relates to a skin composition for promoting skin barrier repairing function, and a preparation method and application thereof, belonging to the field of cosmetics.

Background

The skin is the largest organ which is contacted with the external environment by human beings, covers the whole body, and is the protective umbrella of the outermost layer of other organs of the body. The skin care product has a layer of sebum membrane formed by fusing sebaceous gland lipid, sweat and keratinocyte lipid on the surface, can reduce the evaporation of water on the surface of the skin, can prevent external dust dirt, irritants and the like from invading the skin, provides a natural protective layer for the skin, and is an important structure for maintaining the health of the skin.

In recent years, skin barriers are damaged by excessive cleaning, facial mask application, exfoliating and the like, and once the skin barriers are damaged, the moisture retention capacity of the skin is reduced, so that symptoms such as tightness after washing, dryness, skin lifting, erythema and the like are caused, and even sensitive skin is easily caused. The principle of formation of sensitive skin is due to the problem of the natural defenses of the skin, which results in a loss of barrier ability to external stimuli. The first warning of a decrease in the natural barrier function of the skin is the disruption of the sebaceous membrane.

In human skin, 75% -90% of skin lipids are derived from sebaceous gland secretion, and the rest only 10% -25% of lipids are derived from intercellular lipids, and are mainly synthesized by ceramide, cholesterol and free fatty acids. Among them, fatty acids cannot be synthesized by the human body itself, and unsaturated fatty acids are more advantageous to the human body in particular. Unsaturated fatty acids not only inhibit the inflammatory effects of various mediators and cytokines that cause inflammation but also do not bring about side effects, which brings about a new approach to the treatment of inflammation.

However, for the care of sensitive skin, some natural and non-irritating skin care products are needed, but the components in the natural and non-irritating skin care products can not all show the effects of the components, and the components are added into the product after being compounded, so that the expected effect of repairing the sensitive skin can not be achieved, and the effects of the components can be inhibited mutually, so that the effect of repairing the sensitive skin is poor.

Disclosure of Invention

Problems to be solved by the application

In view of the technical problems existing in the prior art, for example: the application firstly provides a skin composition for promoting skin barrier repairing function, which has the problems of poor absorption of active ingredients, allergy, unobvious effect, unfriendly skin of oil ingredients of skin care products and the like. The skin composition has effects of relieving allergy, improving skin dryness, and effectively repairing skin barrier.

Furthermore, the application also provides a preparation method of the skin composition for promoting the skin barrier repairing function, which is simple and easy to implement, has easily obtained raw materials and is suitable for mass production.

Solution for solving the problem

The present application provides a skin composition comprising an active ingredient in an amount of 0.021 to 50%, preferably 0.1 to 25%, more preferably 0.5 to 10% based on 100% of the total mass of the skin composition; wherein,

the active ingredients comprise chia seed oil, sunflower seed oil unsaponifiable matter and ceramide.

The skin composition according to the present application, wherein the content of the chia seed oil is 0.01% to 30%, preferably 1% to 25%, the content of the sunflower seed oil unsaponifiable matter is 0.01% to 30%, preferably 1% to 25%, and the content of the ceramide is 0.001% to 10%, preferably 0.01% to 8%, based on 100% of the total mass of the skin composition.

The skin composition according to the present application, wherein the mass ratio of the chia seed oil, sunflower seed oil unsaponifiable matter and ceramide is 1-10:1-5:1, preferably 2-8:1.5-4:1.

The skin composition according to the present application, wherein the ceramide is one or a combination of two or more selected from ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, ceramide 6II, ceramide 6, ceramide 7, ceramide 8, ceramide NS, ceramide NP, ceramide EOS, ceramide EOP, ceramide NG, and ceramide AP.

The skin composition according to the present application further comprises one or a combination of two or more of a humectant, a thickener, an emulsifier, a chelating agent, a preservative, and a solvent.

The skin composition according to the present application, wherein the humectant is contained in an amount of 0.01 to 50%, the thickener is contained in an amount of 0.01 to 20%, the emulsifier is contained in an amount of 0.01 to 20%, the chelating agent is contained in an amount of 0.001 to 2%, the preservative is contained in an amount of 0.01 to 5%, and the solvent is contained in an amount of 0 to 98%.

The present application also provides a method of preparing the dermatological composition according to the present application, comprising the step of mixing the components of the dermatological composition.

The application also provides a use of the skin composition according to the application for preparing an external preparation for promoting or enhancing or strengthening the skin barrier function.

The application further provides the use of a dermatological composition according to the application for the preparation of a skin care product.

The use according to the application, wherein the skin care product comprises one of an emulsion, a cream, an essence, a mask, a lotion, a skin oil.

ADVANTAGEOUS EFFECTS OF INVENTION

The skin composition for promoting the skin barrier repairing function has the effects of calming and relieving, resisting bacteria and inflammation, resisting oxidation, resisting ultraviolet and infrared radiation and repairing skin injury, and achieves the effects of enhancing skin resistance, maintaining skin health and stability and relieving skin discomfort.

The preparation method of the skin composition for promoting the skin barrier repairing function is simple and easy, raw materials are easy to obtain, and the skin composition is suitable for mass production.

Detailed Description

The following describes the present application in detail. The following description of the technical features is based on the representative embodiments and specific examples of the present application, but the present application is not limited to these embodiments and specific examples.

Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better illustration of the application. It will be understood by those skilled in the art that the present application may be practiced without some of these specific details. In other instances, well known methods, procedures, means, equipment and steps have not been described in detail so as not to obscure the present application.

It should be noted that:

in the present specification, the use of the meaning of "can" or "can" includes both the meaning of performing a certain process and the meaning of not performing a certain process.

In the present specification, the numerical range indicated by the use of "numerical value a to numerical value B" means a range including the end point numerical value A, B.

Unless otherwise indicated, all units used in the present application are international standard units, and numerical values, ranges of values, appearing in the present application should be understood to include errors permitted in industrial production.

Reference throughout this specification to "some specific/preferred embodiments," "other specific/preferred embodiments," "an embodiment," and so forth, means that a particular element (e.g., feature, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the elements may be combined in any suitable manner in the various embodiments.

In the present specification, if "room temperature", "normal temperature" or the like occurs, the meaning may be "10 to 40 ℃.

In the present specification, the "water" may be any possible "water" in the cosmetic field such as high purity water, purified water, deionized water, distilled water, double distilled water, and the like.

The first aspect of the present application provides a skin composition comprising an active ingredient in an amount of 0.021 to 50%, preferably 0.1 to 25%, more preferably 0.5 to 10%, based on 100% of the total mass of the skin composition, for example: 0.05%, 0.2%, 0.8%, 1%, 3%, 5%, 7%, 9%, 11%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, etc.; wherein,

The skin composition has the effects of calming and relieving, resisting bacteria and inflammation, resisting oxidation, resisting ultraviolet and infrared radiation and repairing skin injury, and has the effects of enhancing skin resistance, maintaining skin health and stability and relieving skin discomfort.

Qiya seed oil

The chia seed oil is vegetable oil obtained by squeezing. The chia seed is seed of Salvia officinalis belonging to peppermint. The Qiya seeds are rich in polyphenols and isoflavones, and these antioxidant compounds have free radical scavenging functions, which reduce the risk of chronic diseases and prevent certain diseases (such as diabetes, alzheimer's disease and Parkinson's disease). Meanwhile, the fat in Qiya seeds is mostly unsaturated fatty acid, the content of Omega-3 and Omega-6 is quite rich, and the Omega-3 has excellent anti-inflammatory effect, can inhibit inflammation and accelerate inflammation repair. Omega-6 is involved in three phases of wound healing: inflammatory phase, proliferation phase, remodeling phase. In the application, the chia seed oil has obvious relieving effect.

In some specific embodiments, the chia seed oil is present in an amount of 0.01% to 30%, preferably 1% to 25%, based on 100% of the total mass of the dermatological composition, for example: 0.5%, 1%, 3%, 5%, 7%, 9%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28%, etc., is effective for soothing the skin when the content of the chia seed oil is 0.01% -30%, particularly 1% -25%. If the content of the chia seed oil is too high, the skin soothing effect is not more obvious in increasing effect and the price is higher.

In some specific embodiments, the chia seed oil may be purchased or prepared in the present application.

Specifically, the chia seed oil can be prepared by a squeezing method. Specifically, the chia seed oil can be pressed by a screw, and in the pressing process, the temperature is maintained at 1-10 ℃ by adding liquid nitrogen, and then the chia seed oil is prepared by filtration.

Unsaponifiable matter of sunflower seed oil

The action mechanism of the sunflower seed oil unsaponifiable matter is to inhibit the release of transcription factor NF-kB & cytokines to reduce skin cell inflammation. Inhibiting the amount of inflammatory cytokines IL1b, IL6, IL8 and TNF alpha, thereby achieving the anti-inflammatory effect. Activating synthesis of key lipids in an in vitro model of skin, enhancing skin barrier function without altering total lipid content.

In some specific embodiments, the sunflower seed oil unsaponifiables are present in an amount of 0.01% to 30%, preferably 1% to 25%, based on 100% total mass of the dermatological composition, for example: 0.5%, 1%, 3%, 5%, 7%, 9%, 10%, 12%, 15%, 18%, 20%, 22%, 25%, 28% and the like, and is effective for soothing the skin when the content of the unsaponifiable matter of sunflower seed oil is 0.01% to 30%, particularly 1% to 25%. If the content of unsaponifiable matter of sunflower seed oil is too high, the skin-soothing effect is not more obvious in increasing effect and the price is higher.

The sunflower seed oil unsaponifiable matter can be purchased and also can be prepared by a molecular distillation technology.

Ceramide

Ceramides (ceramides) are a class of amide compounds formed by dehydration of long-chain fatty acids with sphingosine amino groups, mainly including Ceramide phosphorylcholine and Ceramide phosphorylethanolamine, phospholipids being the main component of cell membranes, 40% -50% of sebum in the stratum corneum being composed of ceramides, which are the main part of intercellular matrix, playing an important role in maintaining the balance of stratum corneum moisture. The ceramide can obviously enhance the adhesion between keratinocytes, improve the dryness of the skin and reduce the desquamation phenomenon of the skin. The ceramide can obviously enhance the adhesion between keratinocytes, improve the dryness of the skin and reduce the desquamation phenomenon of the skin. Ceramide plays a very important role in maintaining the skin barrier function.

In some specific embodiments, the ceramide is present in an amount of 0.001% to 10%, preferably 0.01% to 8%, based on 100% of the total mass of the dermatological composition, for example: 0.005%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, etc., and is effective for soothing the skin when the ceramide content is 0.01% -10%, particularly 0.01% -8%. If the content of ceramide is too high, the skin soothing effect is not more obvious in increasing effect, and the price is higher.

The type of ceramide is not particularly limited, and may be any type commonly used in the art. Specifically, the ceramide is selected from one or more than two of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, ceramide 6II, ceramide 6, ceramide 7, ceramide 8, ceramide NS, ceramide NP, ceramide EOS, ceramide EOP, ceramide NG and ceramide AP.

The present inventors have found that a skin composition comprising chia seed oil, sunflower seed oil unsaponifiable matter and ceramide as active ingredients can effectively repair skin barrier by synergistically enhancing, relieving allergy, improving skin dryness.

Further, in the present application, the content of the active ingredient is 0.01 to 50%, preferably 0.1 to 25%, more preferably 0.5 to 10%, based on 100% by weight of the total mass of the skin composition, for example: 1%, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 19%, 21%, 23%, 25%, 27%, 29%, 31%, 33%, 35%, 37%, 39%, 41%, 43%, 45%, 47%, 49%, etc. When the content of the active ingredient is 0.01-50%, the functions of the unsaponifiable matter of the chia seed oil, the sunflower seed oil and the ceramide can be effectively exerted. When the content of the active ingredient is less than 0.01%, the function of repairing the skin barrier cannot be achieved, and when the content of the active ingredient is more than 50%, the cost is excessively high, and a more excellent effect cannot be obtained.

In some specific embodiments, the mass ratio of the chia seed oil, sunflower seed oil unsaponifiable matter and ceramide is 1-10:1-5:1, preferably 2-8:1.5-4:1, for example: 2.5-8.5:1.8-3.8:1, 3-7:2-3.5:1, 3.5-6.5:2.2-3.2:1, 4-6:2.5-3:1, 4.5-5.5:2.6-2.8:1, 5:2.5:1, etc. When the mass ratio of the chia seed oil, the sunflower seed oil unsaponifiable matter and the ceramide is 1-10:1-5:1, the functions of the chia seed oil, the sunflower seed oil unsaponifiable matter and the ceramide can be effectively exerted, so that the function of repairing the skin barrier is realized.

Other ingredients

The skin composition of the present application may further comprise one or a combination of two or more of a humectant, a thickener, an emulsifier, a chelating agent, a preservative, and a solvent.

The humectant content is 0.01% to 50% based on 100% of the total mass of the skin composition, specifically, the humectant content may be, for example: 1%, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 19%, 21%, 23%, 25%, 27%, 29%, 31%, 33%, 35%, 37%, 39%, 41%, 43%, 45%, 47%, 49%, etc. In the application, when the addition amount of the humectant is 0.01-50%, the moisturizing effect can be achieved.

Specifically, in the application, the humectant comprises one or a combination of more than two of butanediol, panthenol, dipropylene glycol, glycerol, betaine, xylitol, sodium hyaluronate, trehalose, pentanediol, hexanediol and 1, 3-propanediol.

The thickener is present in an amount of 0.01% to 20% based on 100% of the total mass of the dermatological composition. Specifically, the content of the thickener may be, for example: 1%, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 19%, etc. The consistency of the emulsifying system of the present application can be adapted by adding a thickener.

Specifically, in the application, the thickener comprises one or more than two of carbomer, carbomer salt, xanthan gum, sodium polyacrylate, carrageenan, gellan gum, hydroxyethyl cellulose, ammonium acryloyldimethyl taurate/VP copolymer, polyacrylate crosslinked polymer-6 and hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer.

The content of the emulsifier is 0.01-20% based on 100% of the total mass of the skin composition. Specifically, the content of the emulsifier may be, for example: 0.05%, 0.1%, 0.3%, 0.4%, 0.5%, 0.7%, 0.8%, 1%, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 19%, etc. When the dosage of the emulsifier is less than 0.01%, insufficient emulsification is caused, so that the system is unstable; when the dosage of the emulsifier is more than 20%, the irritation of the product can be increased, and meanwhile, the stability of the product can be influenced to a certain extent.

Specifically, in the present application, the emulsifier may include one or a combination of two or more of cetostearyl alcohol, hydrogenated lecithin, cetostearyl glucoside, PEG-100 stearate, polyglyceryl-10 stearate, glyceryl stearate/PEG-100 stearate, sorbitan sesquioleate, isosteareth-20, PEG-10 campesterol, laureth-7, polyglyceryl-3 methyl glucose distearate, PEG/PPG-10/1 polydimethylsiloxane, polyglyceryl-3 diisostearate, glyceryl stearate, steareth-20, cetyl polyether-20, polysorbate-60, cetylstearyl olivoleate, sorbitan olivoleate.

The skin composition of the present application may further comprise a chelating agent. The chelating agent is added in an amount of 0.001% -2% by weight based on the total mass of the emulsifying system. Wherein the chelating agent can be EDTA-2Na and/or EDTA-4Na, etc.

The skin composition of the present application may further comprise a preservative and/or a solvent, wherein the preservative is added in an amount of 0.01 to 5% and the solvent is added in an amount of 0 to 98% based on the total mass of the emulsion system; specifically, the preservative may include one or a combination of two or more of phenoxyethanol, methylparaben, propylparaben, ethylhexyl glycerol, benzoic acid, p-hydroxyacetophenone and salts thereof, and the solvent is water.

Further, the first aspect of the present application also provides a method for preparing the skin composition according to the present application, comprising the step of mixing the components of the skin composition.

The skin composition of the present application can effectively alleviate the problems of redness, stinging, etc. caused by skin sensitivity. According to the application, through compounding the combination of the chia seed oil, the sunflower seed oil unsaponifiable matter and the ceramide, the effect is obviously superior to that of single or simple combination, the synergistic effect can be achieved, and the effects of calming and relieving, resisting bacteria and inflammation, resisting oxidation, resisting ultraviolet and infrared radiation and repairing skin injury are realized. The effects of enhancing skin resistance, maintaining skin health and stability and relieving skin discomfort are realized.

In a second aspect, the present application provides the use of a dermatological composition according to the present application for the preparation of an external preparation for promoting or enhancing or strengthening the barrier function of the skin.

Further, the second aspect of the present application also provides a use of a dermatological composition according to the present application for the preparation of a skin care product. Specifically, the skin care product comprises one of emulsion, cream, essence, facial mask, skin care water and skin care oil. The product prepared by the application is safe and non-irritating, can effectively relieve discomfort caused by skin sensitivity, and is suitable for people of all ages.

Examples

Embodiments of the present application will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present application and should not be construed as limiting the scope of the present application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.

The preparation method of the chia seed oil comprises the following steps:

squeezing by using a screw, simultaneously adding liquid nitrogen to maintain the squeezing temperature at 4 ℃, and filtering to obtain the product.

The sunflower seed oil unsaponifiables were purchased from French LABORATOIRES EXPANSCIENCE company.

Examples 1 to 10

The skin compositions of examples 1 to 10 were prepared according to the following preparation methods based on the mass percentages of the respective components in tables 1 and 2 below.

Wherein, the preparation method of the skin composition comprises the following steps:

1) Adding the sterilized solvent into a reaction kettle, adding the chelating agent, the humectant and the thickener under stirring, stirring uniformly, heating to 82 ℃, adding the active ingredients and the emulsifier, and stirring uniformly.

2) Cooling to 45 ℃, adding preservative, uniformly stirring, cooling to 35 ℃, inspecting, and discharging qualified materials.

Comparative examples 1 to 7 and 9

The skin compositions of comparative examples 1 to 9 were prepared according to the preparation methods of examples 1 to 10 based on the mass percentages of the respective components in the following tables 3 and 4.

Comparative example 8

According to the mass percentages of the components in the following table 4, a skin composition was prepared as follows.

1) Adding sterilized solvent into main pot, adding chelating agent, humectant and thickener under stirring, heating to 82 deg.C, adding mineral wax and emulsifier, and homogenizing and stirring.

Table 1 skin compositions of examples 1-5

TABLE 2 dermatological compositions of examples 6-10

Table 3 dermatological compositions of comparative examples 1-5

Table 4 skin barrier repair compositions of comparative examples 6-9

Performance testing

1. Analysis of the skin's transepidermal loss rate

The skin transepidermal water loss (Trans-epidermal water loss, TEWL) was measured by the germany CK skin moisture loss (TEWL) tester tewatemeter, TM300 and is an important parameter reflecting skin moisture loss and barrier. The lower the value of the variability in the transepidermal water loss rate of the cheek skin, the better the barrier function of the skin.

1. The method for detecting the skin transepidermal water loss rate analysis comprises the following steps:

1.1 subject screening criteria

Healthy female subjects between 20 and 50 years of age; and the subject was positive for skin after 10% lactic acid stinging test (judged as sensitive skin); the face has slight reddening; the number of people is 95, and each sample is randomly 5.

1.2 application sites: face part

1.3 frequency of use: the medicine is used for 1 time in the morning and at night, and is used for 28 days continuously, and 1.2g of medicine is used each time.

1.4 test environmental conditions

The temperature is 21+/-1 ℃ and the relative humidity is 50+/-5%.

1.5 test design

Single blind, random, self front-back control, face (side opposite to lactic acid solution application area selected according to random table).

2. Evaluation method

The skin transepidermal water loss rate was analyzed according to the formula [ (average of skin transepidermal water loss rate on day 28-average of skin transepidermal water loss rate on day 0)/average of skin transepidermal water loss rate on day 0 ], and the results are shown in table 5 below.

Surface 5 differential analysis of the transepidermal loss of water from facial skin

From the results of Table 5, it is seen that the skin after continuous use for 28 days had less water loss through the epidermis than comparative examples 1 to 9 in the case of examples 1 to 10, and the skin barrier was improved as a result of the less water loss through the skin.

Further, as can be seen from examples 1 to 9 and comparative examples 1 to 3, comparative example 8, the dermatological composition of the present application has a remarkable improvement in skin barrier repair as compared with the individual chia seed oil, sunflower seed oil unsaponifiable and ceramide NP, vaseline, and thus the chia seed oil, sunflower seed oil unsaponifiable and ceramide have a remarkable synergistic effect.

2. Pi Fufan red degree analysis

The Pi Fufan redness parameter is obtained by facial Image acquisition by visual-CR and then cheek area skin a value analysis of a picture under Standard2 light source using Image-Pro-Plus Image analysis software, and the smaller the value of the difference in the cheek Pi Fufan redness, the lighter the skin redness.

1. The detection method for Pi Fufan red degree analysis is as follows:

1.1 subject screening criteria

1.2 application sites: face part

1.4 test environmental conditions

The temperature is 21+/-1 ℃ and the relative humidity is 50+/-5%.

1.5 test design

2. Evaluation method details

The skin redness degree was analyzed according to the formula [ (degree of redness on day 28-degree of redness on day 0)/degree of redness on day 0 ], and the results are shown in table 6 below.

Table 6 differential analysis of the red degree of cheeks Pi Fufan

From the results of Table 6, it is seen that the skin redness degree after continuous use for 28 days was more reduced in the cases of examples 1 to 10 than in comparative examples 1 to 9, and the skin barrier was improved as a result of the smaller loss of the percutaneous moisture.

As can be seen from examples 1 to 9 and comparative examples 1 to 3, and comparative example 8, the dermatological composition of the present application has a remarkable improvement in the degree of redness of the skin as compared with the individual chia seed oil, sunflower seed oil unsaponifiable matter and ceramide NP, and vaseline, and thus the chia seed oil, sunflower seed oil unsaponifiable matter and ceramide have remarkable synergistic effects. Thus, the use of the composition of the present application may have the effect of promoting skin barrier repair.

The above examples of the present application are only examples for clearly illustrating the present application, and are not limiting of the embodiments of the present application. Other variations or modifications of the above teachings will be apparent to those of ordinary skill in the art. It is not necessary here nor is it exhaustive of all embodiments. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the application are desired to be protected by the following claims.

Claims

1. A skin composition comprising an active ingredient in an amount of 0.021-50% based on 100% of the total mass of the skin composition; wherein,

the active ingredients comprise chia seed oil, sunflower seed oil unsaponifiable matter and ceramide;

the content of the chia seed oil is 0.01% -30%, the content of the sunflower seed oil unsaponifiable matter is 0.01% -30% and the content of the ceramide is 0.001% -10% based on 100% of the total mass of the skin composition;

the mass ratio of the chia seed oil, the sunflower seed oil unsaponifiable matter and the ceramide is 1-10:1-5:1.

2. The skin composition according to claim 1, wherein the content of the active ingredient is 0.1 to 25% based on 100% of the total mass of the skin composition.

3. The skin composition according to claim 2, wherein the content of the active ingredient is 0.5 to 10% based on 100% of the total mass of the skin composition.

4. A dermatological composition according to any of claims 1 to 3, wherein the amount of chia seed oil is 1% to 25%, the amount of sunflower seed oil unsaponifiables is 1% to 25% and the amount of ceramide is 0.01% to 8% based on 100% total mass of the dermatological composition.

5. A dermatological composition according to any one of claims 1 to 3, wherein the mass ratio of chia seed oil, sunflower seed oil unsaponifiable matter and ceramide is 2-8:1.5-4:1.

6. A dermatological composition according to any one of claims 1 to 3, wherein the ceramide is selected from one or a combination of two or more of ceramide 1, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, ceramide 6II, ceramide 6, ceramide 7, ceramide 8, ceramide NS, ceramide NP, ceramide EOS, ceramide EOP, ceramide NG, ceramide AP.

7. A dermatological composition according to any of claims 1 to 3, further comprising one or a combination of two or more of a humectant, a thickener, an emulsifier, a chelating agent, a preservative, and a solvent.

8. The skin composition according to claim 7, wherein the humectant is 0.01 to 50%, the thickener is 0.01 to 20%, the emulsifier is 0.01 to 20%, the chelating agent is 0.001 to 2%, the preservative is 0.01 to 5%, and the solvent is 0 to 98%.

9. A method of preparing a dermatological composition according to any of claims 1-8, comprising the step of mixing the components of the dermatological composition.

10. Use of a dermatological composition according to any of claims 1-8 for the preparation of an external preparation for promoting or enhancing or strengthening the skin barrier function.

11. Use of a dermatological composition according to any of claims 1-8 for the preparation of a skin care product.

12. The use according to claim 11, wherein the skin care product comprises one of an emulsion, cream, essence, mask, lotion, skin oil.