CN110420132A - Whitening and skin-protecting composition and preparation method thereof - Google Patents
Whitening and skin-protecting composition and preparation method thereof Download PDFInfo
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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Abstract
The present invention provides a kind of whitening and skin-protecting composition, and the composition includes exfoliating ingredient, anti-inflammatory component, conditioning ingredients and matrix components；The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；The matrix components are selected from volatility grease and low molecule grease；Wherein, the volatility grease is selected from one or more of Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane；The low molecule grease is selected from one or more of triglyceride, Parleam, saualane and octyldodecanol.Salubrious non-greasy when whitening and skin-protecting composition use of the present invention, highly-safe, stability is good and can effectively desalinate epidermis spot.
Description
Technical field
The present invention relates to skin care fields, and in particular to a kind of whitening and skin-protecting composition and preparation method thereof.
Background technique
With the development and improvement of living standard of society, female consumer also more closes the functional characteristic of skin-protection product
Note.In recent decades, since the pollution of environment aggravates, harmful chemicals object, stimulant, ultraviolet light for largely discharging etc. are to skin
Injury is increasingly deepened, cutaneous pigmentation and spot is multiple has become the serious skin problem for perplex numerous women, therefore, beautiful
Holding industry has urgent demand for safely and effectively whitening, spot removal and skin care product.
Color spot refers to the spot different with ambient color.Including freckle, blackspot, chloasma and senile plaque etc., belong to pigment barrier
Impenetrability skin disease.Due to dermal melanin increase and the common face of one kind that is formed is brown or melanin pigmentation, damage appearance
The skin disease of property, is mainly in cheek and forehead position, aggravates after solarization, be more common in women.
The dim spot of face, acne, yellowing of the skin accurately say not a kind of disease at last out, only a card type in disease evolutionary process
In some symptom inside have hemostasis mostly due to quite gas and show caused by the symptom of face.
Doctor trained in Western medicine thinks that the dim spot of face, acne, yellowing of the skin are formed by dermal melanin increase or melanin pigmentation out, more
Women is seen, with gestational period anger, paramenia and the drug for taking orally certain impariment of the liver are related, and some after solarization with aggravating, with the autumn
Winter ultraviolet light weakens and mitigates.Common cause are as follows: inherent cause, ultraviolet light irradiation, endocrine disorder, living habit are bad, such as
Pressure is stayed up late, anger, fatigue etc..
Chinese medicine thinks dim spot, goes out acne, the origin cause of formation of yellowing of the skin are as follows: one, because of stagnation of liver qi, causes blood stasis to be reflected in face；Two
Because weakness of the spleen and the stomach, qi and blood cannot moisten face, and the source of vital function is insufficient, it is damp and hot rise to face and formed spot and face it is dry it is yellow,
Withered consumption；Three because deficiency of kidney-QI, imbalance of yin and yang, the deficiency of Yin cause complexion dark, and the deficiency of yang causes yellow complexion.Though its disease type is complicated, they
General character be all to make skin metabolism not normal.In the treatment, it based on being applied with partial face, allows supplemented by its self-regulated.
The main function of human skin is that external substance is prevented to enter body, and outermost layer is played rich in the cuticula of lipoid
Main barrier effect, the layer-by-layer percutaneous absorbtion of effect material demand get to skin corresponding position and play effect.According to phase patibhaga-nimitta
Hold principle, quasi-lipid substance is easier to by percutaneous absorption, infiltration.
Lipophilicity based on skin, compared to aqua skin care item, finish skin care item have more efficient and safe advantage.It is first
First, it is to play one of the premise of effect, and finish is easy to play effect through cuticula that substance, which easily permeates,.Secondly, material sustained-release
It is one of the condition of safety；Substance may be built up during percutaneous absorbtion in skin, form storage, master
Accumulating position is cuticula；After high concentration functional component rapid osmotic skin, the stimulation to skin may be caused；And finish
It needs to distribute by grease again when playing a role, so having slow release effect, avoids excessively concentrating infiltration.Furthermore substance promotees
It can accelerate the transdermal penetration of other stimulus after thoroughly, and finish is relatively simple system, can avoid introducing stimulus.
Patent CN107822944A discloses a kind of personal nursing essential oils and its preparation method and application, is related to beauty guarantor
Strong product field, the constituent including following parts by weight: 4.5-6.5 parts of haematococcus extract, 0.8-1.2 parts of Rosemary Oil,
0.6-1 parts of Lavender, 0.8-1.5 parts of osmanthus essential oil, 0.5-1.5 parts of eucalyptus oil, 0.8-1.2 parts of cape jasmine flower essential oil, the moon
See careless essential oil 1.2-2 parts, 5-15 parts of olive fruit oil, 180-220 parts of jojoba seed oil, the personal nursing that CN107822944A is provided
Essential oils have the advantages of clearing and activating the channels and collaterals, relieve fatigue, whitening sun protection, anti-aging, promote quality of life；But patent
The Whitening, spot low effort of CN107822944A.
Accordingly, in skin care field, need to develop that salubrious non-greasy when a kind of use, highly-safe, stability is good and energy
The effectively whitening and skin-protecting composition of desalination epidermis spot.
Summary of the invention
In view of this, the purpose of the present invention is to provide non-greasy salubrious when a kind of use, it is highly-safe, stablize, and
The whitening and skin-protecting composition of epidermis spot can effectively be desalinated.
For this purpose, the present invention provides following technical schemes.
In a first aspect, the present invention provides a kind of whitening and skin-protecting composition, the composition includes exfoliating ingredient, anti-inflammatory
Ingredient, conditioning ingredients and matrix components；Wherein,
The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The matrix components are selected from volatility grease and low molecule grease；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several.
In a preferred embodiment,
The salicylic parts by weight are 0.1-2；For example, the salicylic parts by weight can for 0.1,0.2,0.3,
0.4,0.5,0.6,0.7,0.8,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9 or 2.
The salicylic parts by weight of decoyl are 0.1-0.5；For example, the salicylic parts by weight of decoyl can be
0.1,0.15,0.2,0.25,0.3,0.35,0.4,0.45 or 0.5.
The parts by weight of the tussol are 0.1-6, for example, the parts by weight of the tussol can for 0.1,0.5,1,
1.5,2,2.5,3,3.5,4,4.5,5,5.5 or 6.
In a preferred embodiment,
The parts by weight of the curcumin are 0.1-1；For example, the parts by weight of the curcumin can for 0.1,0.2,0.3,
0.4,0.5,0.6,0.7,0.8,0.9 or 1.
The parts by weight of the alkyl Radix Glycyrrhizae acid esters are 0.1-1；For example, the parts by weight of the alkyl Radix Glycyrrhizae acid esters can be with
It is 0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9 or 1.
The parts by weight of the bisabolol are 0.2-1；For example, the parts by weight of the bisabolol can for 0.2,
0.3,0.4,0.5,0.6,0.7,0.8,0.9 or 1.
The parts by weight of the totarol are 0.1-1；For example, the parts by weight of the totarol can for 0.1,0.2,
0.3,0.4,0.5,0.6,0.7,0.8,0.9 or 1.
In a preferred embodiment,
The parts by weight of the γ-linolenic acid are 0.1-2；For example, the parts by weight of the γ-linolenic acid can for 0.1,
0.2,0.3,0.4,0.5,0.6,0.7,0.8,0.9,1,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9 or 2.
The parts by weight of the vitamin E are 0.1-1；For example, the parts by weight of the vitamin E can for 0.1,0.2,
0.3,0.4,0.5,0.6,0.7,0.8,0.9 or 1.
In a preferred embodiment,
The parts by weight of the triglyceride are 0.1-50；For example, the parts by weight of the triglyceride can for 0.1,
1,3,5,7,9,10,15,18,20,22,25,28,30,33,36,39,40,43,46 or 50.
The parts by weight of the Parleam are 0.1-50；For example, the parts by weight of the Parleam can
Think 0.1,1,3,5,7,9,10,15,18,20,22,25,28,30,33,36,39,40,43,46 or 50.
The parts by weight of the saualane are 0.1-50；For example, the parts by weight of the saualane can for 0.1,1,3,
5,7,9,10,15,18,20,22,25,28,30,33,36,39,40,43,46 or 50.
The parts by weight of the octyldodecanol are 0.1-50；For example, the parts by weight of the octyldodecanol can
Think 0.1,1,3,5,7,9,10,15,18,20,22,25,28,30,33,36,39,40,43,46 or 50.
Second aspect, the present invention provides a kind of whitening and skin-protecting composition, the composition includes exfoliating ingredient, anti-inflammatory
Ingredient, conditioning ingredients and matrix components；
The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The matrix components are selected from volatility grease and low molecule grease；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several；
Wherein,
The salicylic parts by weight are 0.1-2；
The salicylic parts by weight of decoyl are 0.1-0.5；
The parts by weight of the tussol are 0.1-6；
The parts by weight of the curcumin are 0.1-1；
The parts by weight of the alkyl Radix Glycyrrhizae acid esters are 0.1-1；
The parts by weight of the bisabolol are 0.2-1；
The parts by weight of the totarol are 0.1-1；
The parts by weight of the γ-linolenic acid are 0.1-2；
The parts by weight of the vitamin E are 0.1-1；
The parts by weight of the triglyceride are 0.1-50；
The parts by weight of the Parleam are 0.1-50；
The parts by weight of the saualane are 0.1-50；
The parts by weight of the octyldodecanol are 0.1-50.
The third aspect, the present invention provides a kind of preparation method of whitening and skin-protecting composition, the method includes following step
It is rapid:
S1. it weighs exfoliating ingredient and low molecule grease is added to the container, be heated to 70-80 DEG C, stir evenly, be cooled to 45 DEG C
Below；
S2. anti-inflammatory component, conditioning ingredients and volatility grease are weighed to be added in the mixture that S1 is obtained, is stirred evenly；
Wherein,
The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several.
Fourth aspect provides a kind of whitening product, wherein the whitening product includes composition of the present invention.
5th aspect, provides a kind of light spot product, wherein the light spot product includes composition of the present invention.
6th aspect, provides a kind of pharmaceutical composition, wherein described pharmaceutical composition includes safe and effective amount such as this
The invention whitening and skin-protecting composition.
In addition, additionally providing whitening and skin-protecting composition of the present invention is preparing the use in whitening product or light spot product
On the way.
And additionally provide purposes of the whitening and skin-protecting composition of the present invention in preparation pharmaceutical composition.
In the present invention, pharmaceutical composition includes whitening and skin-protecting composition of the present invention and pharmaceutically acceptable
Auxiliary material.
In the present invention, safe and effective amount refers to that a certain amount of compound or composition, the amount are enough significantly to induce product
The beneficial effect of pole, preferably positive skin histology appearance or feeling beneficial effect, include herein in form independent or combined
Disclosed beneficial effect, but the amount and sufficiently low to avoid serious side effect, i.e., the model rationally judged in technical staff
The interior reasonable effective hazard ratio of offer is provided.
Compared with the existing technology, the beneficial effects of the present invention are:
The specific exfoliating ingredient that whitening and skin-protecting composition of the present invention is selected can be good at extra, the raised angle of removal face
Matter avoids sebaceous lipid accumulation in pore so as to help to dredge pore.
The specific anti-inflammatory component that whitening and skin-protecting composition of the present invention is selected can be good at inhibiting the release of inflammatory factor,
The regeneration for promoting damage skin, keeps skin more healthy.
The specific conditioning ingredients that whitening and skin-protecting composition of the present invention is selected can be good at adjusting hair follicle metabolism, make to thicken
Cutin fall off and dredge hair follicle conduit, adjust the normal function of skin.
The specific volatility grease and low molecule grease that whitening and skin-protecting composition of the present invention is selected, user is when in use
Feel salubrious non-greasy, improves the use feeling of user.
It is damp and hot that whitening and skin-protecting composition of the present invention can remove epidermis, can effective light spot epidermis spot, and reduce
Recur possibility.
The grease of the present invention whitening and skin-protecting composition addition vitamin E and select lightweight, high volatile, spreadability excellent,
There is the benefits of anti-oxidant and adjusting skin sense, so that user is felt salubrious non-greasy when in use, improve the use feeling of user.
The present invention uses pure oil-type, and small molecule oleophylic functional component, small molecule grease is used to promote with the similar principle that mixes
Solve the problems, such as that functional component cannot quickly and effectively enter hair follicle into infiltration.
In addition, whitening and skin-protecting composition of the present invention be able to maintain in low temperature (- 18 DEG C or so) to high temperature (45 DEG C) it is fabulous
Stability, no layering or precipitation, stability are good.
Specific embodiment
Below in conjunction with specific embodiment and embodiment, it is specifically described the present invention, advantages of the present invention and various effects
It thus more will clearly present.It will be understood by those skilled in the art that these specific embodiments and embodiment are for illustrating
The present invention is not intended to limit the present invention.
The present invention is described in more detail by the following examples, but the present invention is not limited to these Examples.
Embodiment 1
The present embodiment provides a kind of whitening and skin-protecting compositions, and according to parts by weight, the composition includes:
0.1 part of salicylic acid, 0.2 part of bisabolol, 0.1 part of vitamin E, 92 parts of Permethyl 99As and 0.1 part of octyldodecanol.
The present embodiment whitening and skin-protecting composition the preparation method is as follows:
S1. it weighs 0.1 part of salicylic acid and 0.1 part of octyldodecanol is added to the container, be heated to 75 DEG C, stir evenly, cool down
To 45 DEG C or less；
S2. it weighs 0.2 part of bisabolol, 0.1 part of vitamin E and 92 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Embodiment 2
The present embodiment provides a kind of whitening and skin-protecting compositions, and according to parts by weight, the composition includes:
2 parts of salicylic acids, 1 part of bisabolol, 1 part of vitamin E, 45 parts of Permethyl 99As and 50 parts of octyldodecanols.
The present embodiment skin care compositions the preparation method is as follows:
S1. 2 parts of salicylic acids are weighed and 50 parts of octyldodecanols are added to the container, 75 DEG C is heated to, stirs evenly, be cooled to 45
DEG C or less；
S2. 1 part of bisabolol, 1 part of vitamin E and 45 parts of Permethyl 99As are weighed to be added in the mixture that S1 is obtained, are stirred evenly
.
Embodiment 3
The present embodiment provides a kind of whitening and skin-protecting compositions, and according to parts by weight, the composition includes:
1 part of salicylic acid, 0.5 part of bisabolol, 0.2 part of vitamin E, 77 parts of Permethyl 99As and 20 parts of octyldodecanols.
The present embodiment skin care compositions the preparation method is as follows:
S1. it weighs 1 part of salicylic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45
DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 1
Beneficial effect in order to further illustrate the present invention provides comparative example 1 and compares with embodiment 3, the difference of the comparative example 1
It is: salicylic acid of the invention is replaced with into Glycolic acid.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 1 part of Glycolic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45
DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 2
Beneficial effect in order to further illustrate the present invention provides comparative example 3 and compares with embodiment 3, the difference of the comparative example 2
It is: bisabolol of the invention is replaced with into dipotassium glycyrrhizinate.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 1 part of salicylic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45
DEG C or less；
S2. 0.5 part of dipotassium glycyrrhizinate, 0.2 part of vitamin E and 77 parts of Permethyl 99As are weighed to be added in the mixture that S1 is obtained, are stirred
It mixes uniformly.
Comparative example 3
Beneficial effect in order to further illustrate the present invention provides comparative example 4 and compares with embodiment 3, the difference of the comparative example 3
It is: vitamin E of the invention is replaced with into vitamin B6.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 1 part of salicylic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45
DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin B6 and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 4
Beneficial effect in order to further illustrate the present invention provides comparative example 4 and compares with embodiment 3, the difference of the comparative example 4
It is: Permethyl 99A of the invention is replaced with into vaseline.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 1 part of salicylic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45
DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of vaseline to be added in the mixture that S1 is obtained, stirring is equal
It is even.
Comparative example 5
Beneficial effect in order to further illustrate the present invention provides comparative example 5 and compares with embodiment 3, the difference of the comparative example 5
It is: octyldodecanol of the invention is replaced with into beeswax.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 1 part of salicylic acid and 20 parts of beeswaxs is added to the container, be heated to 75 DEG C, stir evenly, be cooled to 45 DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 6
Beneficial effect in order to further illustrate the present invention provides comparative example 6 and compares with embodiment 3, the difference of the comparative example 6
It is: salicylic parts by weight is adjusted to 0.06 part.
The comparative example skin care compositions the preparation method is as follows:
S1. it weighs 0.06 part of salicylic acid and 20 parts of octyldodecanols is added to the container, be heated to 75 DEG C, stir evenly, cool down
To 45 DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 7
Beneficial effect in order to further illustrate the present invention provides comparative example 7 and compares with embodiment 3, the difference of the comparative example 7
It is: salicylic parts by weight is adjusted to 2.3 parts.
The comparative example skin care compositions the preparation method is as follows:
S1. 2.3 parts of salicylic acids are weighed and 20 parts of octyldodecanols are added to the container, 75 DEG C is heated to, stirs evenly, be cooled to
45 DEG C or less；
S2. it weighs 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of Permethyl 99As to be added in the mixture that S1 is obtained, stirring
Uniformly.
Comparative example 8
Beneficial effect in order to further illustrate the present invention provides a kind of personal nursing essential oils, which is
Using the method preparation in CN107822944A.
Experiment 1: human body patch experiment
Given the test agent: the sample that 1-3 of the embodiment of the present invention, comparative example 1-8 are prepared.
Experimental subjects: choose 110 volunteers, the age between 20-65 years old, volunteer's skin health, no skin disease mistake
Quick history meets subject's aspiration and is selected into standard.Random grouping, is divided into 11 groups, every group of 10 people.
Experimental principle: referring to Part V human safety in " cosmetics health specification 2015 editions " and efficacy assessments detection
Safety of the human skin patch method validation whitening and skin-protecting composition for human skin in method, skin wrinkle is sturdy to be tested
It is a kind of diagnostic mode for measuring body delayed contact allergy, is set according to IV type skin allergic reaction principle
It is fixed.
Experimental method:
It, will be added with the spot of given the test agent according to the human skin patch of " cosmetics safety technical specification " (2015 editions) records
Examination device is pasted on the back of subject with low sensitization adhesive tape or forearm song is surveyed, and is gently pressed with palm and is allowed to equably be pasted on skin
On, continue for 24 hours.It is potential to human skin to test whitening and skin-protecting composition obtained by 1-3 of the embodiment of the present invention and comparative example 1-8
Adverse reaction.
Wherein, skin wrinkle it is sturdy test reaction grade scale it is as shown in table 1 below.
1 skin wrinkle of table is sturdy to test reaction grade scale
Wherein, experimental result is as shown in table 2 below.
2 human body patch experimental result of table
Skin wrinkle is sturdy to be tested as the result is shown:
Whitening and skin-protecting composition of the present invention observes the dermoreaction of volunteer for 24 hours after the test, and the dermoreaction of volunteer is
Feminine gender illustrates that whitening and skin-protecting composition safety of the present invention is fine, nonirritant to human skin.And by adjusting of the invention
After formula system and using prior art preparation personal nursing essential oils, there are some volunteers suspicious reaction occur, have faint
Erythema.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 6.1 to compare with embodiment 3, the difference of the comparative example 6.1 is: by the parts by weight tune of bisabolol
Whole is 0.1 part；
It provides comparative example 6.2 to compare with embodiment 3, the difference of the comparative example 6.2 is: the parts by weight of vitamin E is adjusted
It is 0.05 part；
It provides comparative example 6.3 to compare with embodiment 3, the difference of the comparative example 6.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 0.05 part；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 1.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 6.1, comparative example 6.2, comparative example 6.3.As a result with class in above-mentioned comparative example 6
Seemingly.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 7.1 to compare with embodiment 3, the difference of the comparative example 7.1 is: by the parts by weight tune of bisabolol
Whole is 1.5 parts；
It provides comparative example 7.2 to compare with embodiment 3, the difference of the comparative example 7.2 is: the parts by weight of vitamin E is adjusted
It is 1.5 parts；
It provides comparative example 7.3 to compare with embodiment 3, the difference of the comparative example 7.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 52 parts；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 1.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 7.1, comparative example 7.2 and comparative example 7.3.As a result in above-mentioned comparative example 7
It is similar.
Experiment 2: efficacy assessments
Given the test agent: the sample that 1-3 of the embodiment of the present invention, comparative example 1-8 are prepared.
Experimental subjects: choosing 110 volunteers, and the age is random to be grouped between 20-65 years old, is divided into 11 groups, every group 10
People.
Experimental method: the sample being prepared using embodiment 1-3, comparative example 1-8, volunteer is sooner or later each daily to smear 1
It is secondary, persistently use 30 days.In this 30 days, volunteer does not use other skin care item (such as facial mask, Essence).
Scoring is 0-5 points, and score value is average mark.0 point indicates no effect, and 1-3 points indicate effective and but are below them
The effect of similar product in mind, 3-4 points are the effect for being equivalent to similar product in their mind, and 4-5 points is beyond their hearts
The effect of similar product in mesh, 5 points are best effect used at present.
The following table 3 lists this evaluation of 110 volunteers to product effect.
3 efficacy assessments result of table
| Greasy feeling | Spreadability | Light spot | |
| Embodiment 1 | 4.3 | 4.4 | 4.1 |
| Embodiment 2 | 4.1 | 4.3 | 4.5 |
| Embodiment 3 | 4.7 | 4.8 | 4.9 |
| Comparative example 1 | 2.3 | 2.5 | 2.6 |
| Comparative example 2 | 2.2 | 2.5 | 2.7 |
| Comparative example 3 | 2.6 | 2.3 | 2.6 |
| Comparative example 4 | 2.5 | 2.2 | 2.5 |
| Comparative example 5 | 2.3 | 2.5 | 2.2 |
| Comparative example 6 | 2.2 | 2.3 | 2.2 |
| Comparative example 7 | 2.3 | 2.5 | 2.7 |
| Comparative example 8 | 4.0 | 3.8 | 2.6 |
Efficacy assessments are as the result is shown:
Whitening and skin-protecting composition of the present invention is easy to smear, and spreadability is good, and patch skin is good, non-greasy, has preferable Whitening, spot
Effect, by advanced optimizing the formula system of whitening and skin-protecting composition, whitening and skin-protecting composition of the present invention, which achieves, more to be managed
The Whitening, spot effect thought.And the whitening and skin-protecting composition of inventive formulation system is not used, and it is not too greasy, it is easier to sprawl,
But Whitening, spot effect is poor.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 6.1 to compare with embodiment 3, the difference of the comparative example 6.1 is: by the parts by weight tune of bisabolol
Whole is 0.1 part；
It provides comparative example 6.2 to compare with embodiment 3, the difference of the comparative example 6.2 is: the parts by weight of vitamin E is adjusted
It is 0.05 part；
It provides comparative example 6.3 to compare with embodiment 3, the difference of the comparative example 6.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 0.05 part；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 2.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 6.1, comparative example 6.2, comparative example 6.3.As a result with class in above-mentioned comparative example 6
Seemingly.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 7.1 to compare with embodiment 3, the difference of the comparative example 7.1 is: by the parts by weight tune of bisabolol
Whole is 1.5 parts；
It provides comparative example 7.2 to compare with embodiment 3, the difference of the comparative example 7.2 is: the parts by weight of vitamin E is adjusted
It is 1.5 parts；
It provides comparative example 7.3 to compare with embodiment 3, the difference of the comparative example 7.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 52 parts；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 2.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 7.1, comparative example 7.2 and comparative example 7.3.As a result in above-mentioned comparative example 7
It is similar.
Experiment 3: stability test
Given the test agent: the sample that 1-3 of the embodiment of the present invention, comparative example 1-8 are prepared.
Experimental method:
By each given the test agent respectively under -18 DEG C, room temperature, 45 DEG C and four test conditions of -18-45 DEG C of alternatings test 15d (day),
30d (day), 40d (day), observing each given the test agent, whether there is or not significant changes, and unchanged to be qualified, it is unqualified for changing, test knot
Fruit is as shown in table 4 below.
4 stability test result of table
It can be seen from the above result that:
Whitening and skin-protecting combination articles of the present invention are surveyed under -18 DEG C, room temperature, 45 DEG C and four test conditions of -18-45 DEG C of alternatings respectively
After trying 15d (day), 30d (day), 40d (day), have no significant change, test result is qualification, i.e., whitening and skin-protecting of the present invention
Composition has good cold resistance and heat resistance, while can satisfy requirement under the conditions of temperature extreme variation.And
The whitening and skin-protecting composition of inventive formulation system is not used, the cold resistance under long-time preservation condition is poor, while nothing
Method meets the requirement under the conditions of temperature extreme variation.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 6.1 to compare with embodiment 3, the difference of the comparative example 6.1 is: by the parts by weight tune of bisabolol
Whole is 0.1 part；
It provides comparative example 6.2 to compare with embodiment 3, the difference of the comparative example 6.2 is: the parts by weight of vitamin E is adjusted
It is 0.05 part；
It provides comparative example 6.3 to compare with embodiment 3, the difference of the comparative example 6.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 0.05 part；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 3.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 6.1, comparative example 6.2, comparative example 6.3.As a result with class in above-mentioned comparative example 6
Seemingly.
Likewise, beneficial effect in order to further illustrate the present invention, provides following comparative example:
It provides comparative example 7.1 to compare with embodiment 3, the difference of the comparative example 7.1 is: by the parts by weight tune of bisabolol
Whole is 1.5 parts；
It provides comparative example 7.2 to compare with embodiment 3, the difference of the comparative example 7.2 is: the parts by weight of vitamin E is adjusted
It is 1.5 parts；
It provides comparative example 7.3 to compare with embodiment 3, the difference of the comparative example 7.3 is: by the parts by weight of octyldodecanol
Number is adjusted to 52 parts；
It is prepared into whitening and skin-protecting composition in conjunction with preparation method of the invention, is tested according to the test method of experiment 3.Evaluation
The effect of whitening and skin-protecting composition prepared by comparative example 7.1, comparative example 7.2 and comparative example 7.3.As a result in above-mentioned comparative example 7
It is similar.
It should be understood that the present invention disclosed is not limited only to specific method, scheme and the substance of description, because these
It is alterable.It will also be understood that purpose of the terminology used here just for the sake of the specific embodiment scheme of description, rather than
It is intended to limit the scope of the invention, the scope of the present invention is limited solely by the attached claims.
Those skilled in the art, which will also be appreciated that or be able to confirm that, uses no more than routine experiment, institute herein
The many equivalents for the specific embodiment of the invention stated.These equivalents are also contained in the attached claims.
Claims (10)
1. a kind of whitening and skin-protecting composition, the composition include exfoliating ingredient, anti-inflammatory component, conditioning ingredients and matrix at
Point；Wherein,
The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The matrix components are selected from volatility grease and low molecule grease；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several.
2. composition according to claim 1, wherein
The salicylic parts by weight are 0.1-2；
The salicylic parts by weight of decoyl are 0.1-0.5；
The parts by weight of the tussol are 0.1-6.
3. composition according to claim 1, wherein
The parts by weight of the curcumin are 0.1-1；
The parts by weight of the alkyl Radix Glycyrrhizae acid esters are 0.1-1；
The parts by weight of the bisabolol are 0.2-1；
The parts by weight of the totarol are 0.1-1.
4. composition according to claim 1, wherein
The parts by weight of the γ-linolenic acid are 0.1-2；
The parts by weight of the vitamin E are 0.1-1.
5. composition according to claim 1, wherein
The parts by weight of the triglyceride are 0.1-50；
The parts by weight of the Parleam are 0.1-50；
The parts by weight of the saualane are 0.1-50；
The parts by weight of the octyldodecanol are 0.1-50.
6. a kind of whitening and skin-protecting composition, the composition include exfoliating ingredient, anti-inflammatory component, conditioning ingredients and matrix at
Point；The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The matrix components are selected from volatility grease and low molecule grease；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several；
Wherein,
The salicylic parts by weight are 0.1-2；
The salicylic parts by weight of decoyl are 0.1-0.5；
The parts by weight of the tussol are 0.1-6；
The parts by weight of the curcumin are 0.1-1；
The parts by weight of the alkyl Radix Glycyrrhizae acid esters are 0.1-1；
The parts by weight of the bisabolol are 0.2-1；
The parts by weight of the totarol are 0.1-1；
The parts by weight of the γ-linolenic acid are 0.1-2；
The parts by weight of the vitamin E are 0.1-1；
The parts by weight of the triglyceride are 0.1-50；
The parts by weight of the Parleam are 0.1-50；
The parts by weight of the saualane are 0.1-50；
The parts by weight of the octyldodecanol are 0.1-50.
7. a kind of preparation method of whitening and skin-protecting composition, the method comprises the following steps:
S1. it weighs exfoliating ingredient and low molecule grease is added to the container, be heated to 70-80 DEG C, stir evenly, be cooled to 45 DEG C
Below；
S2. anti-inflammatory component, conditioning ingredients and volatility grease are weighed to be added in the mixture that S1 is obtained, is stirred evenly；
Wherein,
The exfoliating ingredient is selected from one or more of salicylic acid, decoyl salicylic acid and tussol；
The anti-inflammatory component is selected from one or more of curcumin, alkyl Radix Glycyrrhizae acid esters, bisabolol and totarol；
The conditioning ingredients are selected from γ-one or more of linolenic acid and vitamin E；
The volatility grease in Permethyl 99A, isohexadecane, ring five dimethyl silicone polymer and cyclohexasiloxane one
Kind is several；
The low molecule grease be selected from one of triglyceride, Parleam, saualane and octyldodecanol or
It is several.
8. a kind of whitening product, wherein the whitening product includes composition described in any one of claims 1-6.
9. a kind of pharmaceutical composition, wherein described pharmaceutical composition includes safe and effective amount such as any one of claim 1-6 institute
The whitening and skin-protecting composition stated.
10. whitening and skin-protecting composition described in any one of claims 1-6 is preparing the use in whitening product or pharmaceutical composition
On the way.
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