CN110420132B

CN110420132B - Whitening skin care composition and preparation method thereof

Info

Publication number: CN110420132B
Application number: CN201910810964.5A
Authority: CN
Inventors: 邵静
Original assignee: Xi'an Bohe Medical Technology Co ltd
Current assignee: Xi'an Bohe Medical Technology Co ltd
Priority date: 2019-08-30
Filing date: 2019-08-30
Publication date: 2023-03-17
Anticipated expiration: 2039-08-30
Also published as: CN110420132A

Abstract

The invention provides a whitening skin care composition, which comprises an exfoliating component, an anti-inflammatory component, a conditioning component and a matrix component; the exfoliating component is one or more selected from salicylic acid, caprylyl salicylic acid and mandelic acid; the anti-inflammatory component is one or more selected from curcumin, alkyl glycyrrhetate, bisabolol and totarol; the conditioning component is selected from one or more of gamma-linoleic acid and vitamin E; the matrix component is selected from volatile oil and low molecular oil; wherein the volatile oil and fat is selected from one or more of isododecane, isohexadecane, cyclopentadecyldimethyl siloxane and cyclohexasiloxane; the low molecular oil is selected from one or more of triglyceride, hydrogenated polyisobutene, squalane and octyl dodecanol. The whitening skin care composition is fresh, cool and not greasy, has high safety and good stability when used, and can effectively lighten skin layer spots.

Description

Whitening skin care composition and preparation method thereof

Technical Field

The invention relates to the field of skin care products, and particularly relates to a whitening skin care composition and a preparation method thereof.

Background

With the development of society and the improvement of living standard, the functional characteristics of skin care products are more concerned by female consumers. In recent decades, as environmental pollution is increased, damages to skin caused by a large amount of discharged harmful chemicals, irritants, ultraviolet rays and the like are increased day by day, and skin pigmentation and multiple spots are caused to be serious skin problems which afflict vast women, so that the beauty industry has urgent needs for safe and effective whitening, freckle-removing and skin-care products.

Mottle refers to a spot of a different color from the surrounding. Including freckle, black spot, chloasma and senile plaque, and belongs to skin diseases with dyschromatosis. A common skin disease with brown or melanotic and damaged face caused by the increase of skin melanin is frequently generated at cheek and forehead parts, aggravated after being exposed to the sun and is frequently seen in women.

Dark spots, acne and yellow skin on the face are not exactly a disease, but are only a symptom in a syndrome type in the process of disease evolution, and are mostly caused by symptoms of good vitality and blood stasis in the face.

Western doctors believe that facial dark spots, acne and skin yellowing are caused by increase or pigmentation of skin melanin, are mostly seen in women, are related to qi generation in gestation period, menstrual disorder and oral administration of certain liver injury medicines, are aggravated after solarization, and are relieved by weakening ultraviolet rays in autumn and winter. The common reasons are: genetic factors, ultraviolet radiation, endocrine disorders, and lifestyle disorders such as stress, staying up all night, engendering qi, tiredness, etc.

The traditional Chinese medicine considers that the causes of dark spots, acne and skin yellowing are as follows: blood stasis is reflected on the face due to stagnation of liver qi; secondly, due to weakness of the spleen and the stomach, qi and blood can not moisten the face, the source of the generation is insufficient, and damp heat rises to the face to form spots, dry and yellow face and withered and consumed; the yin deficiency causes dark complexion and the yang deficiency causes yellow complexion due to the kidney qi deficiency and yin-yang imbalance. Although the symptoms are complex, the common symptoms are skin metabolism disorder. In the treatment, the medicine can be locally applied as a main part and can be self-adjusted as an auxiliary part.

The skin of a human body has the main function of preventing external substances from entering the body, the stratum corneum which is rich in lipid at the outermost layer plays a role of a main barrier, and the functional substances can reach the corresponding position of the skin to play a role by percutaneous absorption layer by layer. According to the similar compatibility principle, lipoid substances are easier to absorb and permeate by skin.

Based on the lipophilicity of the skin, oil skin care products have the advantages of being more efficient and safer than aqueous skin care products. First, the ease of penetration of the substance is one of the prerequisites for efficacy, while the oils readily penetrate the stratum corneum for efficacy. Secondly, sustained release of the substance is one of the conditions of safety; substances may accumulate in the skin during the percutaneous absorption process to form a depot, the main accumulation site of which is the stratum corneum; after the high-concentration functional components rapidly permeate the skin, the skin can be stimulated; and the oil agent needs to be subjected to oil-water redistribution when the oil agent plays a role, so that the slow-release effect is achieved, and excessive concentrated permeation is avoided. Moreover, substances promote penetration to accelerate the percutaneous penetration of other stimuli, and oil is a relatively simple system, so that the introduction of stimuli can be avoided.

Patent CN107822944A discloses a personal care essential oil, a preparation method and an application thereof, relating to the field of beauty and health care products and comprising the following components in parts by weight: 4.5-6.5 parts of haematococcus extract, 0.8-1.2 parts of rosemary essential oil, 0.6-1 part of lavender essential oil, 0.8-1.5 parts of sweet osmanthus essential oil, 0.5-1.5 parts of eucalyptus essential oil, 0.8-1.2 parts of gardenia essential oil, 1.2-2 parts of evening primrose essential oil, 5-15 parts of olive fruit oil and 180-220 parts of jojoba seed oil, and the personal care essential oil provided by CN107822944A has the advantages of clearing and activating the channels and collaterals, relieving fatigue, whitening and preventing sunburn, delaying senescence and improving the quality of life; however, the whitening and spot-lightening effect of the patent CN107822944A is weak.

Accordingly, in the field of skin care products, there is a need for the development of a skin-whitening and skin-care composition that is refreshing, non-greasy, highly safe, and stable in use, and that can effectively lighten the spots on the epidermis.

Disclosure of Invention

In view of the above, the present invention aims to provide a skin whitening and caring composition which is fresh and non-greasy when used, has high safety and good stability, and can effectively lighten skin layer spots.

Therefore, the invention provides the following technical scheme.

In a first aspect, the present invention provides a whitening skin care composition comprising an exfoliating component, an anti-inflammatory component, a conditioning component, and a base component; wherein the content of the first and second substances,

the exfoliating component is one or more selected from salicylic acid, caprylyl salicylic acid and mandelic acid;

the anti-inflammatory component is one or more selected from curcumin, alkyl glycyrrhetate, bisabolol and totarol;

the conditioning component is selected from one or more of gamma-linoleic acid and vitamin E;

the matrix component is selected from volatile oil and low molecular oil;

the volatile oil and fat is selected from one or more of isododecane, isohexadecane, cyclopentadecyldimethyl siloxane and cyclohexasiloxane;

the low molecular oil is selected from one or more of triglyceride, hydrogenated polyisobutene, squalane and octyl dodecanol.

In a preferred embodiment of the present invention,

the weight portion of the salicylic acid is 0.1-2; for example, the salicylic acid may be present in a weight fraction of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2.

The weight portion of the octanoyl salicylic acid is 0.1-0.5; for example, the weight fraction of caprylylsalicylic acid may be 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, or 0.5.

The weight part of the mandelic acid is 0.1-6, for example, the weight part of the mandelic acid can be 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5 or 6.

In a preferred embodiment of the method of the present invention,

the weight portion of the curcumin is 0.1-1; for example, the curcumin may be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1 by weight.

The weight portion of the alkyl glycyrrhetate is 0.1-1; for example, the alkyl glycyrrhizinate may be present in an amount of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1 parts by weight.

The weight portion of the bisabolol is 0.2-1; for example, the weight fraction of the bisabolol may be 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1.

The weight portion of the cudrania tricuspidata phenol is 0.1-1; for example, the part by weight of the totarol may be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1.

In a preferred embodiment of the method of the present invention,

the weight portion of the gamma-linoleic acid is 0.1-2; for example, the parts by weight of the gamma-linolenic acid can be 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2.

The weight portion of the vitamin E is 0.1-1; for example, the vitamin E may be present in an amount of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or 1 parts by weight.

In a preferred embodiment of the present invention,

the weight portion of the triglyceride is 0.1-50; for example, the weight fraction of the triglyceride may be 0.1, 1, 3, 5, 7, 9, 10, 15, 18, 20, 22, 25, 28, 30, 33, 36, 39, 40, 43, 46, or 50.

The hydrogenated polyisobutene accounts for 0.1-50 parts by weight; for example, the hydrogenated polyisobutene can be present in a weight fraction of 0.1, 1, 3, 5, 7, 9, 10, 15, 18, 20, 22, 25, 28, 30, 33, 36, 39, 40, 43, 46 or 50.

The weight portion of the squalane is 0.1-50; for example, the squalane can be present in a weight fraction of 0.1, 1, 3, 5, 7, 9, 10, 15, 18, 20, 22, 25, 28, 30, 33, 36, 39, 40, 43, 46, or 50.

The weight portion of the octyl dodecanol is 0.1-50; for example, the parts by weight of the octyldodecanol can be 0.1, 1, 3, 5, 7, 9, 10, 15, 18, 20, 22, 25, 28, 30, 33, 36, 39, 40, 43, 46, or 50.

In a second aspect, the present invention provides a whitening skin care composition comprising an exfoliating ingredient, an anti-inflammatory ingredient, a conditioning ingredient and a base ingredient;

the matrix component is selected from volatile oil and low molecular oil;

the low molecular oil is selected from one or more of triglyceride, hydrogenated polyisobutene, squalane and octyl dodecanol;

wherein the content of the first and second substances,

the weight portion of the salicylic acid is 0.1-2;

the weight portion of the octanoyl salicylic acid is 0.1-0.5;

the weight portion of the mandelic acid is 0.1-6;

the weight portion of the curcumin is 0.1-1;

the weight portion of the alkyl glycyrrhetate is 0.1-1;

the weight portion of the bisabolol is 0.2-1;

the weight portion of the cudrania tricuspidata phenol is 0.1-1;

the weight portion of the gamma-linoleic acid is 0.1-2;

the weight portion of the vitamin E is 0.1-1;

the weight portion of the triglyceride is 0.1-50;

the hydrogenated polyisobutene accounts for 0.1-50 parts by weight;

the weight portion of the squalane is 0.1-50;

the weight portion of the octyl dodecanol is 0.1-50.

In a third aspect, the present invention provides a method for preparing a whitening skin care composition, comprising the steps of:

s1, weighing cutin-removed components and low-molecular-weight grease, adding into a container, heating to 70-80 ℃, uniformly stirring, and cooling to below 45 ℃;

s2, weighing the anti-inflammatory component, the conditioning component and the volatile oil and fat, adding the anti-inflammatory component, the conditioning component and the volatile oil and fat into the mixture obtained in the S1, and uniformly stirring;

wherein the content of the first and second substances,

the conditioning component is one or more selected from gamma-linoleic acid and vitamin E;

In a fourth aspect, there is provided a whitening product, wherein the whitening product comprises the composition of the present invention.

In a fifth aspect, there is provided a spot-lightening product, wherein the spot-lightening product comprises the composition of the present invention.

In a sixth aspect, a pharmaceutical composition is provided, wherein the pharmaceutical composition comprises a safe and effective amount of the whitening skin care composition according to the invention.

In addition, the invention also provides application of the whitening and skin-care composition in preparing whitening products or spot-lightening products.

And also provides application of the whitening and skin-care composition in preparation of a pharmaceutical composition.

In the invention, the pharmaceutical composition comprises the whitening skin-care composition and pharmaceutically acceptable auxiliary materials.

In the present invention, a safe and effective amount refers to an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin tissue appearance or feel benefit, including the benefits disclosed herein, either individually or in combination, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.

Compared with the prior art, the invention has the beneficial effects that:

the specific exfoliating component selected by the whitening and skin care composition can well remove redundant and raised cutin on the face, so that pores can be dredged, and sebum is prevented from being accumulated in the pores.

The specific anti-inflammatory component selected by the whitening and skin-care composition can well inhibit the release of inflammatory factors, promote the regeneration of damaged skin and make the skin healthier.

The specific conditioning component selected by the whitening and skin-care composition can well regulate the metabolism of hair follicles, so that thickened cutin falls off to dredge the hair follicle conduit and regulate the normal functions of skin.

The specific volatile oil and low-molecular-weight oil selected by the whitening and skin-care composition disclosed by the invention have the advantages that a user feels fresh and non-greasy when using the whitening and skin-care composition, and the use feeling of the user is improved.

The whitening skin care composition can remove dampness and heat of epidermis, can effectively lighten spots on the epidermis layer, and reduces the possibility of relapse.

The whitening skin care composition is added with vitamin E and selects grease with light weight, high volatility and excellent spreadability, has the effects of resisting oxidation and regulating skin feel, enables users to feel fresh and not greasy when using, and improves the use feeling of the users.

The invention adopts a pure oil formulation, and adopts micromolecular oleophylic functional components and micromolecular grease to promote penetration by a similar intermiscibility principle to solve the problem that the functional components can not quickly and effectively enter hair follicles.

In addition, the whitening skin care composition can keep excellent stability at low temperature (about 18 ℃) to high temperature (45 ℃), does not have layering or precipitation and has good stability.

Detailed Description

The present invention will be specifically explained below with reference to specific embodiments and examples, and the advantages and various effects of the present invention will be more clearly demonstrated. It will be understood by those skilled in the art that these specific embodiments and examples are for the purpose of illustrating the invention and are not to be construed as limiting the invention.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

Example 1

The embodiment provides a whitening and skin-care composition, which comprises the following components in parts by weight:

0.1 part of salicylic acid, 0.2 part of bisabolol, 0.1 part of vitamin E, 92 parts of isododecane and 0.1 part of octyldodecanol.

The preparation method of the whitening and skin-care composition comprises the following steps:

s1, weighing 0.1 part of salicylic acid and 0.1 part of octyldodecanol, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

s2, weighing 0.2 part of bisabolol, 0.1 part of vitamin E and 92 parts of isododecane, adding the mixture obtained in the S1, and uniformly stirring.

Example 3

1 part of salicylic acid, 0.5 part of bisabolol, 0.2 part of vitamin E, 77 parts of isododecane and 20 parts of octyldodecanol.

The skin care composition of this example was prepared as follows:

s1, weighing 1 part of salicylic acid and 20 parts of octyldodecanol, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

s2, weighing 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of isododecane, adding the mixture obtained in the S1, and uniformly stirring.

Comparative example 1

To further illustrate the beneficial effects of the present invention, comparative example 1 is provided, which comparative example 1 differs from example 3 in that: the salicylic acid of the present invention is replaced with glycolic acid.

The comparative skin care composition was prepared as follows:

s1, weighing 1 part of glycolic acid and 20 parts of octyldodecanol, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

Comparative example 2

To further illustrate the beneficial effects of the present invention, comparative example 3 is provided, and this comparative example 2 differs from example 3 in that: the bisabolol of the present invention is replaced with dipotassium glycyrrhizinate.

The comparative skin care composition was prepared as follows:

s2, weighing 0.5 part of dipotassium glycyrrhizinate, 0.2 part of vitamin E and 77 parts of isododecane, adding the mixture obtained in the S1, and uniformly stirring.

Comparative example 3

To further illustrate the beneficial effects of the present invention, comparative example 4 is provided, which comparative example 3 differs from example 3 in that: vitamin E of the present invention is replaced with vitamin B6.

The comparative skin care composition was prepared as follows:

s2, weighing 0.5 part of bisabolol, 0.2 part of vitamin B6 and 77 parts of isododecane, adding the mixture obtained in the S1, and uniformly stirring.

Comparative example 4

To further illustrate the beneficial effects of the present invention, comparative example 4 is provided, which comparative example 4 differs from example 3 in that: the isododecane of the present invention was replaced with petrolatum.

The comparative skin care composition was prepared as follows:

s2, weighing 0.5 part of bisabolol, 0.2 part of vitamin E and 77 parts of vaseline, adding into the mixture obtained in the S1, and uniformly stirring.

Comparative example 5

To further illustrate the beneficial effects of the present invention, comparative example 5 is provided, which comparative example 5 differs from example 3 in that: the octyldodecanol of the present invention was replaced with beeswax.

The comparative skin care composition was prepared as follows:

s1, weighing 1 part of salicylic acid and 20 parts of beeswax, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

Comparative example 6

To further illustrate the beneficial effects of the present invention, comparative example 6 is provided, which comparative example 6 differs from example 3 in that: the weight portion of the salicylic acid is adjusted to be 0.06 portion.

The comparative skin care composition was prepared as follows:

s1, weighing 0.06 part of salicylic acid and 20 parts of octyldodecanol, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

Comparative example 7

To further illustrate the beneficial effects of the present invention, comparative example 7 is provided, which comparative example 7 differs from example 3 in that: the weight portion of the salicylic acid is adjusted to be 2.3 portions.

The comparative skin care composition was prepared as follows:

s1, weighing 2.3 parts of salicylic acid and 20 parts of octyldodecanol, adding into a container, heating to 75 ℃, uniformly stirring, and cooling to below 45 ℃;

Comparative example 8

To further illustrate the benefits of the present invention, a personal care essential oil is provided, which is prepared using the method in CN 107822944A.

Experiment 1: human body patch experiment

And (3) testing a sample: the samples prepared in inventive examples 1 and 3, and comparative examples 1-8.

Subjects: selecting 110 volunteers, wherein the volunteers are 20-65 years old, have healthy skin and no allergic history of skin diseases, and meet the volunteer selection standard of the test subject. Randomly grouped into 11 groups of 10 people each.

The experimental principle is as follows: the safety of the whitening skin-care composition on human skin is verified by referring to a human skin patch test method in a fifth part human safety and efficacy evaluation detection method in 'cosmetic hygiene Specification 2015', and a skin patch test is a diagnosis mode for determining delayed contact allergy of an organism and is set according to the IV-type skin allergy principle.

The experimental method comprises the following steps:

according to the human skin patch test described in "technical Specification for safety of cosmetics" (2015 edition), a patch test device containing a test sample was applied to the back or forearm of a subject with a hypoallergenic tape, and the patch was applied to the skin uniformly under light pressure with the palm for 24 hours. The whitening skin care compositions prepared in examples 1 and 3 and comparative examples 1 to 8 of the present invention were tested for potential adverse reactions to human skin.

The skin patch test reaction grading standard is shown in the following table 1.

TABLE 1 grading Standard of skin Patch test response

The experimental results are shown in table 2 below.

TABLE 2 test results of human body patch

The skin patch experimental result shows that:

the skin reactions of the volunteers are observed 24h after the experiment, and the skin reactions of the volunteers are negative, which shows that the whitening and skin-care composition has good safety and no irritation to human skin. After the formula system of the invention is adjusted and the personal care essential oil prepared by the prior art is used, some volunteers have suspicious reactions and weak erythema.

Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:

comparative example 6.1 is provided, which is distinguished from example 3 by the following: adjusting the weight portion of the bisabolol to 0.1 portion;

comparative example 6.2 is provided, which comparative example 6.2 differs from example 3 in that: adjusting the weight part of the vitamin E to 0.05 part;

comparative example 6.3 is provided, which comparative example 6.3 differs from example 3 in that: adjusting the weight portion of the octyl dodecanol to 0.05 portion;

the whitening skin care composition prepared by combining the preparation method of the invention is tested according to the test method of experiment 1. The whitening skin care compositions prepared in comparative example 6.1, comparative example 6.2, and comparative example 6.3 were evaluated for efficacy. The results were similar to those in comparative example 6 described above.

comparative example 7.1 is provided, which is distinguished from example 3 by the following: adjusting the weight part of the bisabolol to 1.5 parts;

comparative example 7.2 is provided, which comparative example 7.2 differs from example 3 in that: adjusting the weight part of the vitamin E to 1.5 parts;

comparative example 7.3 is provided, which comparative example 7.3 differs from example 3 in that: adjusting the weight part of the octyl dodecanol to 52 parts;

the whitening skin care composition prepared by combining the preparation method of the present invention was tested according to the test method of experiment 1. The whitening skin care compositions prepared in comparative example 7.1, comparative example 7.2 and comparative example 7.3 were evaluated for efficacy. The results were similar to those in comparative example 7 described above.

Experiment 2: evaluation of efficacy

And (3) testing a sample: the samples prepared in inventive examples 1 and 3, comparative examples 1-8.

Subject: 110 volunteers were selected, aged 20-65 years, and randomly grouped into 11 groups of 10 persons each.

The experimental method comprises the following steps: using the samples prepared in examples 1 and 3, comparative examples 1-8, volunteers applied 1 time each day, morning and evening, for 30 days. During the 30 days, the volunteers did not use other skin care products (such as facial mask, essence, etc.).

The score is 0-5 points, and the score is the average score. Score 0 indicates no effect, score 1-3 indicates effect but less than the same type of product in their eyes, score 3-4 is equivalent to the same type of product in their eyes, score 4-5 is beyond the same type of product in their eyes, and score 5 is the best effect currently used.

The evaluation of the effect of the product by these 110 volunteers is shown in Table 3 below.

TABLE 3 evaluation results of efficacy

	Greasy feeling	Spreadability	Speckle reduction
				Example 1	4.3	4.4	4.1
Example 3	4.7	4.8	4.9
				Comparative example 1	2.3	2.5	2.6
Comparative example 2	2.2	2.5	2.7
				Comparative example 3	2.6	2.3	2.6
Comparative example 4	2.5	2.2	2.5
				Comparative example 5	2.3	2.5	2.2
Comparative example 6	2.2	2.3	2.2
				Comparative example 7	2.3	2.5	2.7
Comparative example 8	4.0	3.8	2.6

The efficacy evaluation results show that:

the whitening and skin-care composition is easy to apply, good in spreadability, good in skin-sticking property, not greasy and good in whitening and spot-fading effects, and achieves more ideal whitening and spot-fading effects by further optimizing the formula system of the whitening and skin-care composition. The whitening skin care composition without the formula system is not greasy and is easy to spread, but has poor whitening and spot-lightening effects.

comparative example 6.1 is provided, which is different from example 3 in that: adjusting the weight part of the bisabolol to 0.1 part;

the whitening skin care composition prepared by combining the preparation method of the present invention was tested according to the test method of experiment 2. The whitening skin care compositions prepared in comparative example 6.1, comparative example 6.2, and comparative example 6.3 were evaluated for efficacy. The results were similar to those in comparative example 6 described above.

the whitening skin care composition prepared by combining the preparation method of the present invention was tested according to the test method of experiment 2. The whitening skin care compositions prepared in comparative example 7.1, comparative example 7.2 and comparative example 7.3 were evaluated for efficacy. The results were similar to those in comparative example 7 described above.

Experiment 3: stability test

The experimental method comprises the following steps:

the tested samples are tested for 15 days, 30 days and 40 days under four test conditions of-18 ℃, room temperature, 45 ℃ and-18-45 ℃ alternately, and the tested samples are observed to have obvious change, pass or fail, and the test results are shown in the following table 4.

Table 4 stability test results

From the above results, it can be seen that:

after the whitening and skin-protecting combined article is tested for 15 days, 30 days and 40 days under four test conditions of-18 ℃, room temperature, 45 ℃ and-18-45 ℃ alternately, the whitening and skin-protecting combined article has no obvious change, and the test results are all qualified, namely the whitening and skin-protecting combined article has good cold resistance and heat resistance and can meet the use requirements under the condition of extreme temperature change. The whitening skin care composition without the formula system has poor cold resistance under long-term storage conditions, and cannot meet the use requirements under extreme temperature change conditions.

comparative example 6.1 is provided, which is different from example 3 in that: adjusting the weight portion of the bisabolol to 0.1 portion;

comparative example 6.3 is provided, which comparative example 6.3 differs from example 3 in that: adjusting the weight part of the octyl dodecanol to 0.05 part;

the whitening skin care composition prepared by combining the preparation method of the present invention was tested according to the test method of experiment 3. The whitening skin care compositions prepared in comparative examples 6.1, 6.2, and 6.3 were evaluated for efficacy. The results were similar to those in comparative example 6 described above.

comparative example 7.1 is provided, which is different from example 3 in that: adjusting the weight part of the bisabolol to 1.5 parts;

comparative example 7.2 is provided, which is distinguished from example 3 by the following: adjusting the weight part of the vitamin E to 1.5 parts;

the whitening skin care composition prepared by combining the preparation method of the invention is tested according to the test method of experiment 3. The whitening skin care compositions prepared in comparative example 7.1, comparative example 7.2 and comparative example 7.3 were evaluated for efficacy. The results were similar to those in comparative example 7 described above.

It is to be understood that the invention disclosed is not limited to the particular methodology, protocols, and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.

Those skilled in the art will also recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

Claims

1. A whitening and skin-care composition comprises the following components in parts by weight:

2. A method of preparing a whitening skin care composition, the method comprising the steps of:

3. A whitening product, wherein said whitening product comprises the composition of claim 1.

4. Use of the whitening skin care composition of claim 1 in the preparation of a whitening product.