CN106466261B - Health skin care compositions - Google Patents

Abstract

The invention discloses a kind of health skin care compositions, based on the gross mass of health skin care compositions, be made of following raw material: hyaluronic acid 0.1%-1%, aloe extract 5%-20%, Flos Caryophylli extract 0.1%-2%, licorice 0.1%-2%, Leonurus extract 0.1%-2%, cimicifuga foetida extract 0.1%-1%, Flos Sophorae extract 0.1%-1%, Radix Platycodonis extract 0.1%-1%, ethyl alcohol 0.1%-5%, auxiliary material 0.1%-2%, surplus are water.The present invention provide a kind of additive level it is extremely low, it is nontoxic, highly-safe, nonirritant, have preferable moisture retention, it can go deep into deep skin and skin care, be suitable for ripe age skin, be suitable for allergic constitution crowd, antiallergy, the health skin care compositions of allergy or eczema crowd can be cured, can be widely applied to the fields such as health care product, skin care item, daily personal care articles.

Description

Health skin care compositions

Technical field

The present invention relates to a kind of cosmetics, more specifically, it relates to a kind of health skin care compositions.

Background technique

With the continuous improvement of people's living standards, cosmetics have become the necessary article in daily life.

Water content in skin especially cuticula is important moulding object, and moisture content is about 10%- in cuticle layer 15%, the relative constant of water depends on nature moisturizing factor.With the increase at age or the influence of environment, the nature of skin Moisturizing factor content is reduced, and declines skin hydration ability, it appears and it is dry, wrinkle even occurs.Therefore, moisturizing is to improve skin The most underlying issue of skin is the essential condition for guaranteeing skin health, anti-aging.

It is being presently considered completely inadequate however, relying solely on moisturizing and carrying out skin care.In recent years, because of environmental pollution, drink The variation of structure, the increasing of survival pressure are eaten, allergy especially skin allergy crowd has biggish rising.With regard to anaphylactic disease Speech, avoiding contact with anaphylactogen is one of prevention pathogenetic measure of disease, is effective control allergic reaction degree using drug therapy Main means.However, containing more chemical addition agent in Traditional makeup, skin not can avoid these chemistry additions of contact Agent and be likely to occur it is red and swollen, itch, peel and the abnormal phenomenon such as allergic dermatitis.Chemistry is added in cosmetics currently, also having The method of drug anti-allergic agent, however the mechanism of action of these anti-allergic agents waits to study, and has potential hidden danger.China's Chinese medicine Medicine is resourceful, finds superior anti-allergic agent for us and provides the foundation.

Current consumer more has chasing after deliberately in addition to the security requirement of cosmetics is high, to cosmetics the effect of property It asks, can predict continue to bring out using bioengineering preparation and natural plant extraction object as the cosmetics of representative.

Summary of the invention

In view of the deficiencies of the prior art, the present invention intends to provide, a kind of additive level is extremely low, nontoxic nothing It is harmful, highly-safe, nonirritant, there is preferable moisture retention, deep skin and skin care can be goed deep into, be suitable for ripe age flesh Skin is suitable for allergic constitution crowd, antiallergy, can cure allergy or the health skin care compositions of eczema crowd.

A kind of health skin care compositions is made of following raw material based on the gross mass of health skin care compositions: hyaluronic acid 0.1%-1%, aloe extract 5%-20%, Flos Caryophylli extract 0.1%-2%, licorice 0.1%-2%, Leonurus extract It is 0.1%-2%, cimicifuga foetida extract 0.1%-1%, Flos Sophorae extract 0.1%-1%, Radix Platycodonis extract 0.1%-1%, ethyl alcohol 0.1%-5%, auxiliary Expect that 0.1%-2%, surplus are water.

Preferably, the gross mass based on health skin care compositions, is made of following raw material: hyaluronic acid 0.1%, aloe mention Object 20%, Flos Caryophylli extract 2%, licorice 1.5%, Leonurus extract 1.2%, cimicifuga foetida extract 0.5%, sophora flower is taken to extract Object 0.5%, Radix Platycodonis extract 0.5%, ethyl alcohol 3%, auxiliary material 0.2%, surplus are water.

Preferably, the hyaluronic acid includes that small-molecular-weight hyaluronic acid, middle-molecular-weihydroxyethyl hyaluronic acid and macromolecule are saturating Bright matter acid；The molecular weight of the small-molecular-weight hyaluronic acid is 400,000-1000,000, the molecule of middle-molecular-weihydroxyethyl hyaluronic acid Amount is 1000,000-1800,000, and the molecular weight of macromolecule hyaluronic acid is 1800,000-2200,000.

Preferably, the auxiliary material is the acceptable auxiliary material of cosmetic field, can be selected from: moisturizer, preservative, antioxygen Agent, pH regulator, emulsifier, lubricant and other functional additives.

A kind of preparation method being exclusively used in health skin care compositions, which comprises the steps of:

Step 1: aloe, cloves, Radix Glycyrrhizae, motherwort, cimicifugae foetidae, sophora flower, the campanulaceae prepared slices of Chinese crude drugs are crushed respectively, mistake 40 mesh are sieved to obtain fine powder；

Step 2: the fine powder that step 1 obtains is thrown into extraction kettle respectively, it is passed through carbon dioxide, flow velocity 20kg/h, Pressure is 40MPa, and temperature is 35-50 DEG C, is extracted, extraction time 4-8 hours, respectively obtains respective Chinese medical extract；

Step 3: the ethyl alcohol of formula ratio, auxiliary material are mixed, a small amount of water is added, stirs, is heated to 55-65 DEG C, and keep the temperature 5- 15 minutes, the processing of first time cooling later；

Step 4: the hyaluronic acid, aloe extract, cloves that formula ratio is added extract when temperature is reduced to 45-50 DEG C Object, licorice, Leonurus extract, cimicifuga foetida extract, Flos Sophorae extract, Radix Platycodonis extract, benefit are filled with water to formula ratio, protect It is 5-15 minutes warm, the processing of second of cooling later；

Step 5: temperature is reduced to 35-38 DEG C, the preparation to health skin care compositions is completed；

The sum of mass percent of each component is 100% in health skin care compositions.

It is preferred that the health skin care compositions is following form: facial mask, lotion, face cream, Essence, eye cream.

In the present invention, the effect of each raw material in health skin care compositions is respectively as follows:

Hyaluronic acid: a kind of acidic mucopolysaccharide substance adjusts skin barrier effect and inhibition moisture of skin damage due to having It loses and there are high moisture-keeping functions.The stretching, extension of its molecule space is especially big, and loose, expansion molecular shape accounts for it in the solution According to biggish space, can also have high viscosity, high viscoelasticity and Thief zone even at a low concentration in conjunction with larger amount of water Pressure, makes it have very strong water conservation and lubricating action.It is shown in body more with its unique molecular structure and physicochemical property The important physiological function of kind, such as lubricating joint adjust the permeability of vascular wall, regulatory protein matter, Water-Electrolyte diffusion and operating, Promote wound healing etc..Small-molecular-weight hyaluronic acid (molecular weight 400,000-1000,000) can penetrate into corium, have slight Capillary is expanded, increases blood circulation, improves intermediate supersession, promotes skin-nourishing absorption, there is stronger wrinkle-chasing function Can, skin elasticity, delay skin aging can be increased.Middle-molecular-weihydroxyethyl hyaluronic acid (molecular weight 1000,000-1800,000) can With compact skin, permanent moisturizing, macromolecule hyaluronic acid (molecular weight 1800,000-2200,000) can be in skin surface shape At one layer of ventilative film, it is wet to make skin smooth, and the intrusion of alien bacteria, dust, ultraviolet light can be obstructed, protection skin is exempted from It is encroached on.

Aloe has effects that product, defaecation desinsection are led in heat-clearing；There are antitumor, protection liver, anti-gastric injury, antibacterial etc. to make With.Aloe extract mainly contains aloin, Barbaloin, isobarbaloin, aloe-emodin, aloe rheum officinale Phenol, aloe polysaccharide, also containing ingredients such as amino acid, organic acid, vitamin and enzymes.Aloe extract energy accelerated cell growth promotees It heals into tissue repair and window；There is excellent nutrition and moisten effect to skin, there is moisturizing, antiallergic, promote skin new Old metabolism mitigates wrinkle of skin, increases the effects of skin elasticity and gloss；There is inhibiting effect to fungies such as dermatophytes.

Cloves has effects that middle benefit gas drop is inverse, tonifies the kidney and support yang；There is antibacterial, promotes gastric secretion, antiulcer, promotes bile The effects of secretion, throe, anti anoxia, antithrombotic, anticoagulation and platelet aggregation-against.Flos Caryophylli extract contains volatile oil, contains in oil Eugenol, acetyleugenol, β-carypohyllene and gaultherolin, benzaldehyde, benzyl acetate, chavicol, ylangene Deng.Flos Caryophylli extract can be used as the add pastil of cosmetics, be also used as preservative；Has the effects that antiallergic；Tinea can be treated And eczema.

Radix Glycyrrhizae has effects that invigorating middle warmer and replenishing QI, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, mitigates pharmacological property；Have antiulcer, Removing toxic substances, liver protection, cholagogue, adrenocortical hormones fuction, anti-inflammatory, antiallergy, antibechic, antidiuresis, reducing blood lipid, the disease-resistant micro- life of original Object, it is antitumor the effects of.Licorice contains glycyrrhizin and a variety of flavone compounds.Licorice can be neutralized, be solved The toxic side effect for removing or reducing Cucumber in cosmetics is also possible to prevent allergic reaction of the cosmetics to human body.

Motherwort has effects that promoting blood circulation for regulating menstruation, inducing diuresis to remove edema；There is decompression, inhibits dermatophyte, antithrombus formation, resists Myocardial ischemia improves the effects of microcirculation, diuresis.Motherwort extracting solution is female containing leonurine, stachydrine, leonuridine alkali, benefit Careless peaceful alkali, rutin sophorin, sterol, benzoic acid, lauric acid, linolenic acid, β-linolenic acid, oleic acid, fumarase etc..Motherwort extracting solution Have the function of antibacterial, improve microcirculation, can prevent wrinkle from generating, softening skin, prevention and treatment freckle, senile plaque and pachylosis.

Sophora flower has effects that cooling blood and hemostasis, blood pressure lowering；There is hemostasis, spasmolysis, antiulcer, anti-inflammatory, blood pressure lowering, antimycotic The effects of.Sophora flower extracting solution sweat rutin sophorin, sophora flower A prime, tannin, grease, volatile oil and carbohydrate.Sophora flower extracting solution to X-ray and Ultraviolet light irradiation has protective effect.The ethanol water of sophora flower extracting solution is able to maintain skin and moistens, is fine and smooth, can treat anaphylaxis skin Scorching and antiinflammation.

Campanulaceae has effects that promoting the dispersing function of the lung relieving sore-throat, eliminating the phlegm apocenosis；There are eliminating the phlegm, anti-inflammatory, antiallergy, antibacterial, hypoglycemic, drop blood The effects of rouge, decompression, expansion blood vessel, anti-gastric-ulcer.Radix Platycodonis extract contains platycodin, separately contains spinasterol, platycogenic acid, chrysanthemum Sugar, platycodonin, fat oil, vitamin etc..Radix Platycodonis extract has inhibiting effect to Epidermophyton, and can be used as Porcelana Skin Bleaching Agent Porcelana makes Whitening skin.

Cimicifugae foetidae has effects that deliver promoting eruption, clearing heat and detoxicating, lifting disease；There is antipyretic, anti-inflammatory, analgesia, calm, disease-resistant The effects of substance.Cimicifuga foetida extract is containing cimitin, cimicifugine, cimigenol, salicylic acid, tannin, caffeic acid, ferulic acid etc.. It is used together with Flos Sophorae extract, Radix Platycodonis extract, saponin(e, flavone compound, terpene is mainly contained in these three extracts Compound, tannic acid, amino acid and inorganic salts etc..These substances, which are combined, can generate synergistic effect, blood can be promoted to follow Ring；Improve capillary of skin physiological function etc., have moist effect to skin, and the coarse of skin can be eliminated, make skin gloss, It is fine and smooth.

Health skin care compositions provided by the invention has the following advantages compared with prior art:

1, additive level is extremely low, toxicity test discovery, the percutaneous LD of rabbit₅₀Greater than 2180mg/kg, the LD of rat oral₅₀ Greater than 5000mg/kg, therefore health skin care compositions of the invention belongs to practical nontoxic cosmetics, nontoxic, safety It is high.

2, Skin Irritation Test is found, healthy adult rabbit does not occur after smearing health skin care compositions of the invention Erythema or oedema phenomenon are nonirritant.

3, human body patch test finds that health skin care compositions of the invention has no adverse reaction to human body, nonirritant.

4, normal individual trial test discovery, health skin care compositions of the invention have preferable moisture retention, can go deep into skin Deep layer and skin care.

5, crowd's normal individual trial test discovery in 35-60 years old, health skin care compositions of the invention have preferable moisture retention, Deeper into deep skin and skin care, it can preferably be suitable for ripe age skin.

6, sensitive constitution normal individual trial test discovery, health skin care compositions of the invention is non-stimulated, is also applied for allergy Constitution crowd.

7, the discovery of allergy normal individual trial test, health skin care compositions of the invention is non-stimulated, and energy antiallergy can cure Allergic human population caused by partly cause.

8, eczema normal individual trial test discovery, health skin care compositions of the invention is non-stimulated, can cure partly cause and draw The eczema crowd risen.

9, herbaceous plant percutaneously gives nutrition and the health care of Chinese tradition, beauty and skin care, nutraceutical scheduling theory phase In conjunction with herbaceous plant environmental protection is pure natural, can promote the nutrition such as cell active absorption hyaluronic acid after entering skin, allow cell It is healthier.

10, the form of medication such as the injection of hyaluronic acid are changed to external application, absorbed faster, efficiency is higher, nontoxic stingless Swash property.

Specific embodiment

The preparation of aloe extract: the aloe prepared slices of Chinese crude drugs are crushed, and are crossed 40 mesh and are sieved to obtain aloe fine powder.By aloe Fine powder is thrown into extraction kettle, and carbon dioxide, flow velocity 20kg/h, pressure 40MPa are passed through, and temperature is 35-50 DEG C, is extracted It takes, extraction time 4-8 hours, obtains aloe extract.

The preparation of cloves, Radix Glycyrrhizae, motherwort, cimicifugae foetidae, sophora flower, Radix Platycodonis extract: cloves, Radix Glycyrrhizae, motherwort, liter are used respectively Fiber crops, sophora flower, campanulaceae replace aloe, other steps are constant, respectively obtain cloves, Radix Glycyrrhizae, motherwort, cimicifugae foetidae, sophora flower, campanulaceae and extract Object.

Hyaluronic acid, directly in buying on the market, the small-molecular-weight hyaluronic acid in the hyaluronic acid of purchase containing equivalent (molecular weight 400,000-1000,000), middle-molecular-weihydroxyethyl hyaluronic acid (molecular weight 1000,000-1800,000) He great Fen Son amount hyaluronic acid (molecular weight 1800,000-2200,000).

Embodiment one

3 parts of ethyl alcohol, 0.1 part of vitamin E (antioxidant) and 0.1 part of glycerol (moisturizer) are taken, puts into reaction pot, adds Enter 10 parts of water, 3000 revs/min of speed stirrings are heated to 60 DEG C, heat preservation cools down after 15 minutes.Temperature of reaction system is reduced to 45 DEG C, into reaction pot be added 0.1 part of hyaluronic acid, 20 parts of aloe extract, 2 parts of Flos Caryophylli extract, 1.5 parts of licorice, 1.2 parts of Leonurus extract, 0.5 part of cimicifuga foetida extract, 0.5 part of Flos Sophorae extract, 0.5 part of Radix Platycodonis extract supplement water 60.5 Part, heat preservation cools down after 15 minutes.Temperature of reaction system is reduced to 35 DEG C, and reaction terminates, and completes the system to health skin care compositions It is standby.

Embodiment two

Take 5 parts of ethyl alcohol, 0.1 part of vitamin E (antioxidant), 1.8 parts of glycerol (moisturizer) and paraben esters (preservative) It 0.1 part, puts into reaction pot, is added 20 parts of water, 3000 revs/min of speed stirrings are heated to 65 DEG C, heat preservation is dropped after 15 minutes Temperature.Temperature of reaction system is reduced to 50 DEG C, and 0.5 part of hyaluronic acid, 10 parts of aloe extract, cloves are added into reaction pot and extracts 1 part of object, 2 parts of licorice, 0.1 part of Leonurus extract, 1 part of cimicifuga foetida extract, 1 part of Flos Sophorae extract, Radix Platycodonis extract 1 Part, 56.4 parts of water are supplemented, heat preservation cools down after five minutes.Temperature of reaction system is reduced to 38 DEG C, and reaction terminates, and completes to protect health The preparation of skin composition.

Embodiment three

0.1 part of ethyl alcohol and 0.1 part of vitamin E (antioxidant) are taken, is put into reaction pot, 5 parts of water of addition, 3000 turns/ Minute speed stirring, is heated to 55 DEG C, heat preservation cools down after five minutes.Temperature of reaction system is reduced to 45 DEG C, is added into reaction pot 1 part of hyaluronic acid, 0.1 part of Flos Caryophylli extract, 0.1 part of licorice, 2 parts of Leonurus extract, rises 5 parts of aloe extract 0.1 part of nettle extract, 0.1 part of Flos Sophorae extract, 0.1 part of Radix Platycodonis extract supplement 86.3 parts of water, and heat preservation cools down after 15 minutes. Temperature of reaction system is reduced to 36 DEG C, and reaction terminates, and completes the preparation to health skin care compositions.

Test example one, toxicity test

1. acute dermal toxicity test

Prepare before test: selecting the adult rabbit of two kinds of genders, rabbit weight range is 2.0-3.0kg.Experimental rabbit exists Observation 3-5 days, adapt it to environment, and observe its health status in cage for animal.First 24 hours of formal administration, by back part of animal ridge Column two sides hair scissors fall or shave off, and are careful not to scratch.

Test method: the adult rabbit of two kinds of genders is randomly divided into 5 groups, every group 10 respectively.Each 5 groups of two kinds of genders Adult rabbit applied dose be 0mg/kg, 5mg/kg, 45mg/kg, 350mg/kg and 2180mg/kg, every group of adult respectively The health skin care compositions of rabbit application same dose.Wherein, the representation method of dosage are as follows: with experimental animal mean unit weight The quality (mg/kg) of application tested material.Tested material is equably applied to back part of animal, animal body surface area is no less than at smearing 10%.It is covered after smearing with oilpaper and two layers of gauze, then is fixed with nonirritant adhesive plaster, licked with anti-dropout and animal Tested material is applied health skin care compositions 24 hours altogether.After the test, remaining tested material is removed with warm water.Observation one week is seen The systemic toxicity profiles performance and death condition, the variation including animal skin, hair, eyes and mucous membrane for examining animal, breathe, recycle, From the variation of central nervous system of advocating peace, four limbs activity and behavior etc., it is important to note that observation trembles, faints from fear, salivating, abdomen Phenomena such as rushing down, be drowsiness, going into a coma.By oilpaper and two layers of gauze covering, then it is subject to fixed processing method with nonirritant adhesive plaster and makees For control.

Test result: 5 groups of male adult rabbit and 5 groups of female adult rabbit do not occur dead or intoxication conditions, show Normally.The percutaneous LD of rabbit in this test₅₀Greater than 2180mg/kg, so tested material belongs to practical nontoxic health skin care compositions.

2. acute oral toxicity test

Prepare before test: selecting the adult rat of two kinds of genders, rat body weight range is 180-200g.Rat is prohibited before testing Food 16 hours, not water restriction.

Test method: the adult rat of weighed two kinds of genders is randomly divided into 5 groups, every group 10 respectively.Each 5 groups The adult rat applied dose of two kinds of genders is 0mg/kg weight, 1mg/kg weight, 50mg/kg weight, 500mg/kg respectively Weight and 5000mg/kg weight, the health skin care compositions of every group of adult rat application same dose.With water by different meterings Health skin care compositions is configured to the tested material of 1.0ml/100g weight, and tested material was divided into 2 in 24 hours with stomach-filling syringe needle Secondary administration.After administration, general status, poisoning manifestations and the death condition for observing and recording animal are kept a close eye on.By the water of same amount Administration is as control in the same way.

Test result: 5 groups of male adult rats and 5 groups of female adult rats do not occur dead or intoxication conditions, show Normally.The LD of rat oral in this test₅₀Greater than 5000mg/kg, so tested material belongs to practical nontoxic health skincare composition Object.

Test example two, Skin Irritation Test

Prepare before test: selecting 10 healthy adult rabbit.

Acute skin irritation test method (a dermal application experiment): first 24 hours of formal administration, by back part of animal ridge Column two sides hair scissors fall, and can not damage epidermis, the left and right each about 3cm × 6cm of unhairing range.Tested material 0.1g is taken to be coated directly on skin On skin, covered after smearing with oilpaper and two layers of gauze, then fixed with nonirritant adhesive plaster, application 24 hours.Off-test Residual tested material is removed with warm water afterwards.Position dermoreaction is smeared in observation in 1,24,48 and 72 hour after removing tested material, by table 1 carried out dermoreaction scoring, carries out overall merit with the average value of animal subject integral, according to each observation in 24,48 and 72 hours Time point top mean value determines skin irritatin intensity by table 2.By oilpaper and the covering of two layers gauze, then with nonirritant adhesive plaster It is subject to fixed processing method as control.

Multiple Skin-test method: back part of animal backbone two sides hair scissors are fallen, and can not damage epidermis, unhairing range is left, Right each about 2.5cm × 2.5cm.It takes tested material 0.1g to be coated directly on skin, is covered after smearing with oilpaper and two layers of gauze, then use Nonirritant adhesive plaster is fixed, and smears primary, continuous 14 days smearings daily, smears the observation of the latter hour every time as a result, pressing Table 1 scores, and according to daily every animal average integral, determines skin irritatin intensity by table 2.Cropping is answered before smearing every time, it must not Damage skin guarantees that tested material comes into full contact with skin.Residual tested material is removed with warm water after the test.By oilpaper and two layers Gauze covering, then nonirritant adhesive plaster is used to be subject to fixed processing method as control.

Acute skin irritation test result: 10 healthy adult rabbit of observation smeared position at 1,24,48 and 72 hour Dermoreaction does not occur erythema or oedema phenomenon, is nonirritant.

Multiple skin test results: the skin that 10 healthy adult rabbit of observation smear position when smearing for continuous 14 days is anti- It answers, does not occur erythema or oedema phenomenon, be nonirritant.

Test example three, human body patch test

Prepare before test: selecting subject by subject enrollment standard, number is 500.Subject enrollment standard is The volunteer that Pass Test in 18 ~ 60 years old requires is as study subject, and the person that cannot select following situations is as subject:

(1) nearly one week using antihistamine or it is one month nearly in use immunosuppressor person；

(2) recipient site applies any anti-inflammatory drug person in nearly two months；

(3) subject is not cured person with inflammatory dermatoses clinic；

(4) insulin-dependent diabetes mellitus patient；

(5) receiving the asthma or other chronic respiratory disease patients for the treatment of；

(6) person that receives anticancer chemotherapy in nearly 6 months；

(7) immune deficiency or autoimmune disease patient；

(8) nursing period or gravid woman；

(9) bilateral mastectomy and bilateral axillary lymph node dissection person；

(10) test result is influenced due to scar, pigment, atrophy, nevus flammeus or other flaws at skin position to be tried Judgement person；

(11) other clinical trial investigators are participated in；

(12) the highly sensitive person of constitution；

(13) non-aspiration participant or cannot by test requirements document complete specified content person.

Test method: taking 0.03ml tested material, is added dropwise on the filter paper appended by spot tester and is placed in spot tester.Not set The spot tester of the attached filter paper of any substance is as blank control.It will be pasted on added with the spot tester of tested material with non-stimulated adhesive tape The back or forearm song side of subject, is gently pressed with palm and is allowed to equably be pasted on skin, continue 24 hours.Remove tested material It is spaced 30 minutes after spot tester, observes dermoreaction after impression disappearance.If result be feminine gender, after patch test 24 hours and It observes again respectively within 48 hours primary.Reaction result is recorded by 3 dermoreaction grade scale of table.

Test result: dermoreaction, equal nothing in 500 subjects are observed after being spaced 30 minutes after removal tested material spot tester Reaction.It observes again respectively within 24 hours and 48 hours after patch test once, it is reactionless in 500 subjects.Illustrate tested Object has no adverse reaction to human body.

Test example four, normal individual trial test

Prepare before test: selecting subject by subject enrollment standard, number is 1000.Subject enrollment standard and The subject enrollment standard of human body patch test is identical.

Test method: being divided into two groups for 1000 subjects at random, and one group uses health skin care compositions of the invention, separately One group uses moisturizing cosmetic conventional on the market as control.Subject makes after washing away foul on the face with conventional facial cleanser With 0.5ml tested material, any other cosmetics is not used during test.Respectively at 0 day, 1 day, 7 days, 14 days, 30 days, 90 days With 360 days, observe the skin conditions of subject.Wherein, change of skin situation is with the skin at tested initial stage for control.

Test result: as shown in table 4.There is situations such as dry, furfur and microgroove in lengthening at any time, skin.Control group With test group at 14 days and its before change of skin situation be not much different, have no significant change.At 30 days and its later with it is right It is compared according to group, the number of cases that test group generates dehydrating phenomena (drying, furfur and microgroove etc.) is less, and rate of rise is lower.Therefore, It is compared with control group, health skin care compositions of the invention has better moisture retention, can more go deep into deep skin, can be more preferable Ground skin care.

Test example five, crowd's normal individual trial test in 35-60 years old

Prepare before test: selecting subject by subject enrollment standard, number is 1000.Except the age is limited to 35- 45 years old, subject enrollment standard was identical with the subject enrollment standard of human body patch test.

Test method: being divided into two groups for 1000 subjects at random, and one group uses health skin care compositions of the invention, separately One group uses cosmetics conventional on the market as control.Subject uses after washing away foul on the face with conventional facial cleanser 0.5ml tested material does not use any other cosmetics during test.Respectively at 0 day, 1 day, 7 days, 14 days, 30 days, 90 days and 360 days, observe the skin conditions of subject.Wherein, change of skin situation is with the skin at tested initial stage for control.

Test result: as shown in table 5.In 35-60 years old crowd, skin aging is serious, and cases of dehydration becomes apparent from, to moisturizing Demand becomes apparent from.There is situations such as dry, furfur and microgroove in lengthening at any time, skin.Control and test group at 7 days and its it Preceding change of skin situation is not much different, and has no significant change.It is compared at 14 days and its later with control group, test group generates The number of cases of dehydrating phenomena (drying, furfur and microgroove etc.) is less, and rate of rise is lower.Therefore it is compared with control group, the present invention Health skin care compositions there is better moisture retention, can more go deep into deep skin, can preferably skin care, can be preferable Suitable for ripe age skin.

Test example six, sensitive constitution normal individual trial test

Prepare before test: selecting subject by subject enrollment standard, number is 1000.Except subject is sensitive body The subject enrollment standard of matter, subject enrollment standard and human body patch test is identical.Allergic constitution of the invention, refers to At least 3 allergic reactions when using cosmetics on the market.

Test method: being divided into two groups for 1000 subjects at random, and one group uses health skin care compositions of the invention, separately One group uses moisturizing cosmetic conventional on the market as control.Subject makes after washing away foul on the face with conventional facial cleanser With 0.5ml tested material, any other cosmetics is not used during test.Respectively at 0 day, 1 day, 7 days and 30 days, observe tested The allergic conditions of person.Wherein, change of skin situation is with the skin at tested initial stage for control.Allergic conditions include comprising All including skin allergy are because use the allergic phenomena generated after cosmetics.

Test result: as shown in table 6.There is more allergic reaction in control group, and allergy occurs with using the time to lengthen The number of cases of situation increases.During test, the allergic reaction that test group occurs is few, and the allergic reaction occurred is reversible, can Self-healing.Therefore it is compared with control group, health skin care compositions of the invention is non-stimulated, is also applied for allergic constitution crowd.

Test example seven, allergy normal individual trial are tested

Prepare before test: selecting subject by subject enrollment standard, number is 1000.Except subject is allergy The subject enrollment standard of human body, subject enrollment standard and human body patch test is identical.Allergy human body of the invention, refers to It is to have the human body of phenomena such as light red spot, erythema and small pox on skin.

Test method: being divided into two groups for 1000 subjects at random, and one group uses health skin care compositions of the invention, separately One group uses moisturizing cosmetic conventional on the market as control.Subject makes after washing away foul on the face with conventional facial cleanser With 0.5ml tested material, any other cosmetics is not used during test.Respectively at 0 day, 1 day, 7 days and 30 days, observe tested The skin of person especially allergy region the case where.Wherein, change of skin situation is with the skin at tested initial stage for control.

Test result: as shown in table 7.In control group, after using commercially available cosmetics, partial symptoms add allergy human body Weight, only a small amount of patient symptom slows down.In test group, allergy human body is after using health skin care compositions of the invention, no disease Shape aggravate the case where, part symptom slow down or symptom disappear, and with use lengthen curative effect it is more preferable.Therefore with control group phase Than, health skin care compositions of the invention is non-stimulated, can antiallergy, allergic human population can be cured caused by partly cause.

Test example eight, the test of eczema normal individual trial

Prepare before test: selecting subject by subject enrollment standard, number is 1000.Except subject is eczema people The subject enrollment standard of body, subject enrollment standard and human body patch test is identical.Eczema human body of the invention, refers to Occurs the human body of slight or a small amount of eczema on skin.

Test method: being divided into two groups for 1000 subjects at random, and one group uses health skin care compositions of the invention, separately One group uses moisturizing cosmetic conventional on the market as control.Subject makes after washing away foul on the face with conventional facial cleanser With 0.5ml tested material, any other cosmetics is not used during test.Respectively at 0 day, 1 day, 7 days and 30 days, observe tested The skin of person especially eczema region the case where.Wherein, change of skin situation is with the skin at tested initial stage for control.

Test result: as shown in table 8.In control group, after using commercially available cosmetics, partial symptoms aggravate eczema human body, Only a small amount of patient symptom slows down.In test group, eczema human body is after using health skin care compositions of the invention, asymptomatic exacerbation The case where, part symptom slow down or symptom disappear, and with use lengthen curative effect it is more preferable.Therefore it is compared with control group, this hair Bright health skin care compositions is non-stimulated, can cure eczema crowd caused by partly cause.

The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (5)

1. a kind of health skin care compositions, which is characterized in that the gross mass based on health skin care compositions, by following raw material group At: hyaluronic acid 0.1%-1%, aloe extract 5%-20%, Flos Caryophylli extract 0.1%-2%, licorice 0.1%-2%, benefit are female Careless extract 0.1%-2%, cimicifuga foetida extract 0.1%-0.5%, Flos Sophorae extract 0.1%-0.5%, Radix Platycodonis extract 0.1%-0.5%, Ethyl alcohol 0.1%-5%, auxiliary material 0.1%-2%, surplus are water.

2. health skin care compositions according to claim 1, which is characterized in that total matter based on health skin care compositions Amount, is made of following raw material: hyaluronic acid 0.1%, aloe extract 20%, Flos Caryophylli extract 2%, licorice 1.5%, benefit are female It is careless extract 1.2%, cimicifuga foetida extract 0.5%, Flos Sophorae extract 0.5%, Radix Platycodonis extract 0.5%, ethyl alcohol 3%, auxiliary material 0.2%, remaining Amount is water.

3. health skin care compositions according to claim 1, which is characterized in that the auxiliary material is acceptable for cosmetic field Auxiliary material, can be selected from: moisturizer, preservative, antioxidant, pH regulator, emulsifier, lubricant and other effects Additive.

4. a kind of preparation method of health skin care compositions as described in any one of claims 1-3, which is characterized in that including such as Lower step:

Step 1: aloe, cloves, Radix Glycyrrhizae, motherwort, cimicifugae foetidae, sophora flower, the campanulaceae prepared slices of Chinese crude drugs are crushed respectively, 40 mesh are crossed Sieving obtains fine powder；

Step 2: the fine powder that step 1 obtains is thrown into extraction kettle respectively, it is passed through carbon dioxide, flow velocity 20kg/h, pressure For 40MPa, temperature is 35-50 DEG C, is extracted, extraction time 4-8 hours, respectively obtains respective Chinese medical extract；

Step 3: the ethyl alcohol of formula ratio, auxiliary material are mixed, a small amount of water is added, stirs, is heated to 55-65 DEG C, and keeps the temperature 5-15 points Clock, the processing of first time cooling later；

Step 4: be reduced to 45-50 DEG C when temperature, the hyaluronic acid of formula ratio, aloe extract, Flos Caryophylli extract, sweet is added Careless extract, Leonurus extract, cimicifuga foetida extract, Flos Sophorae extract, Radix Platycodonis extract, benefit are filled with water to formula ratio, keep the temperature 5- 15 minutes, the processing of second of cooling later；

Step 5: temperature is reduced to 35-38 DEG C, the preparation to health skin care compositions is completed；

The sum of mass percent of each component is 100% in health skin care compositions.

5. health skin care compositions according to claim 1-3, which is characterized in that the health skin care compositions It is following form: facial mask, lotion, face cream, Essence, eye cream.