CN1243744A - Aloe composition - Google Patents

Abstract

An aloe composition as Chinese medicinal health-care food for smokers is prepared from fresh leaf of aloe (50-80%), bluish dogbane leaf (2-20%), houttuynia (2-20%), platycodon root (1-2%), liquorice root (1-2%) and honey (8-14%) through extracting glue liquid from aloe, immersing extracting others, mixing them and addition of antiseptic and antioxidizing agent. It can effectively detoxicate nicotin and tar in the smoker's body and improve the resistance and immunity to radiation damage.

Description

Aloe composition

The present invention relates to a kind of pharmaceutical composition that alleviates smoking to the harm of health, particularly a kind of is that main material is equipped with the compositions that other Chinese medicine is made with the Aloe.

Smoking is clear and definite to the harm of human body, and particularly the harm maximum of nicotine in the Nicotiana tabacum L. and tar is considered to carcinogenic arch-criminal.How to resolve " smoking with healthy " this to contradiction, make the smoker normally smoking again smoking is reduced to less limit to the harm of health, become urgency problem to be solved.

In recent years, world many countries all the research Aloe, all has clear and definite demonstration to aloetic Detoxication, enhancing immunity effect, beautification function etc. in the prior art.Published by Jilin science and technology publishing house in January, 1999, the 123rd page of " the practical encyclopaedia of Aloe " book of Meng Xiangying chief editor discloses Aloe poisonous medicine had function of detoxification.Publish by Science and Technology of Shanghai document publishing house in October, 1994, " harmfulness of smoking good health and a long life " book 84-85 page or leaf of Gu Xueqiu chief editor has such elaboration: smoking has tangible supression and damage to the nonspecific immunity and the defensive enginery of body ... according to scholar's research in recent years, composition superoxides qi enzyme (the Superoxide di smutase that contains polysaccharose substance in the aloetic gel (Aloe Vera Gel) and remove free radical, be called for short SOD), polysaccharide composition in the Aloe can improve body's immunological function, increase the quantity of macrophage and phagocytic function to antibacterial and virus, the smoker takes aloe preparation, can make injured immune system recover normal.

The problem that prior art exists is: simple aloe preparation can not nicotine elimination, tar is to the harm of human body; Simple aloe preparation effect aspect enhancing body radiation-resisting functional and raising immunity is good inadequately.

The purpose of this invention is to provide a kind of Aloe Chinese medicine composition, it more can reduce the harm to human body of nicotine, tar effectively than the single aloe preparation, lower its toxicity, improve body Antiradiation injury function, very big human body immunity improving power, said composition is equipped with medicine or the food acceptable additive is made multiple medicine and food, makes things convenient for the smoker edible.

Aloe composition of the present invention mainly is made up of the following materials material:

The preferred 65-75% of Fresh leaf of aloe 50-80%

The preferred 2.5-4% of Folium Apocyni Veneti 2-20%

Herba Houttuyniae 2-20%

Radix Platycodonis 1-2%

Radix Glycyrrhizae 1-2%

Mel 8-14%,

It is an amount of also can to add Oleum menthae in the aloe composition, to producing the refrigerant sense of taste; Also can add 1-20% Radix Ginseng or Radix Codonopsis or Radix Pseudostellariae.

Containing antioxidant in the aloe composition, is vitamin C, also contains antiseptic, is sodium benzoate, and the two is 1 ‰ by the composition material weight ratio.

The pharmacological effect of each composition is as follows in the aloe composition:

Aloe: Xin Liang, body are slided, are moisturized, relieving constipation, scorching, the wet dissipation detoxifcation of reconciliation, have raise immunity, anticancer, radioprotective, antiinflammatory, protect the liver, the effect of detoxifcation, relieving constipation, increase interleukin, eliminate endotoxin, can obviously improve patient's overall health of patients;

Folium Apocyni Veneti: reduce nicotine and tar content, and tracheitis there is certain preventive and therapeutic effect (come from People's Medical Officer Press Chen Shu sesame and compile " smoking is with healthy "), the leukocyte increasing number proves radiation resistance and reinforced immunological effect (coming from People's Health Publisher 96.10 " national Chinese herbal medicine compilation ");

Herba Houttuyniae: strengthen the leukocytes phagocytic ability, strengthen non-specific immunity (coming from above-mentioned " national Chinese herbal medicine compilation "), contained grease has bacteriostasis (coming from " Chinese medicine voluminous dictionary "), increases to be equipped with the element that is situated between, and improves immunity (coming from Chengdu Traditional Chinese Medical College's " Chinese materia medica ");

Radix Platycodonis: the clinical effectiveness identical with penicillin arranged, and good to pharyngeal antiinflammatory effect than penicillin, complication is less, and (come from " Chinese Medical Journal 60:46:132 ", contained kikyosaponin can promote the respiratory mucus secretion increasing, sharp eliminating phlegm and expelling toxin;

Radix Glycyrrhizae: have moderate Detoxication (coming from " pharmaceutical journal " (day) 86.828.96) significantly to reduce urethane, arsenobenzene (nuisance in the tar), histamine's toxicity to cigarette alkali;

Mel: refrigerant, seasoning, detoxifcation, anticorrosion;

Herba Menthae: hot icy gas, cleaning heat and expelling wind;

Radix Ginseng: Attenuation, radiation resistance (coming from " pharmaceutical journal " (day) 73.841.19.63)

Smoking is nicotine and tar to the nuisance of human body maximum.The smoker often shows dry mouth and parching tongue, expectorant is sticking and many, the tongue fur BOHUANG, faint and rapid pulse, the damp-heat in upper-JIAO syndrome, the present invention is to lead lung-heat off, clearing throat, the detoxifcation pathogenic fire purging reduces the harm to human body of nicotine, tar to reach, and lowers its toxicity, human body immunity improving power, Herba Apocyni veneti and Radix Glycyrrhizae have nuisance content effect in the nicotine of minimizing and tar and the cigarette in the aloe composition of the present invention, Aloe, Radix Platycodonis all have relieving constipation, expectorant effect, assist toxin expelling, thereby lower the harm of nuisances such as nicotine and tar to the smoker effectively; Contain radiocancerogenesis material polonium-210 in the medicated cigarette, after entering human body with smoking, locate to build up once more at blood, liver, pancreas, kidney, lymph node, bone marrow etc., distribute lonizing radiation, immunocyte around destroying causes radiation damage, and aforementioned " the practical encyclopaedia of Aloe " book proves for the 88th page, Aloe extract has the Antiradiation injury effect that strengthens Herba Apocyni veneti extract, illustrates that the radiation damage that the present composition causes smoking simultaneously has therapeutical effect preferably; Aloe, Herba Apocyni veneti, Herba Houttuyniae all have the macrophage of increasing and quantity of leucocyte in the compositions, strengthen the effect that it engulfs the antibacterial ability, and Herba Houttuyniae increases plain antibiotic, the sharp expectorant of Radix Platycodonis antiinflammatory that is situated between fully, thereby greatly improves body's immunological function.More singly with its anti-tobacco poisoning evil ability of aloe preparation, enhancing body Antiradiation injury ability and immunocompetence effect obviously strengthen this multiple components synergism.

By following animal experiment, prove that compositions of the present invention is nontoxic, and can reduce the toxicity that nicotine, tar produce health effectively, thereby safeguard the health of body.

Test one:

Get 30 of qualified mices, body weight is 20 grams ± 2 grams, is divided into high dose group, low dose group and matched group at random, 10 every group, and high dose group administration 0.4ml//day, the 1ml=1g dose; Low dose group administration 0.4ml//day, the 1ml=0.33g dose.Calculate with mice 20 gram body weight, dosage is equivalent to 15 times and 5 times of human dosage respectively, the matched group feedwater.Administration every day 1 time, successive administration 20 days, after time administration 1 hour, each treated animal stomach to succi Nicotiana tabacum L. 0.4ml/ was only irritated, and (1ml succi Nicotiana tabacum L.=2 a smoke from cigarette amount) observed 48 hours, the results are shown in Table:

Group quantity survival number death toll P

Only 55＜0.5 of high dose group l0

10 37＞0.5 of low dose group

10 0 10 of matched groups

Result of the test shows that smoking beginning in preceding 20 days administration is after the smoking, high dose group mice survival rate is 50%, and the low dose group survival rate is 30%, and not administration group survival rate is 0, the proof present composition truly has the effect of removing toxicity of cigarette, and detoxifying effect is directly proportional with dosage.

Test two:

Get 20 of qualified mices, body weight is 30 grams ± 2 grams, is divided into S group and T group, the passive smoking of S group nature, the passive smoking+administration of T group nature.T only organizes medical ether gastric infusion 0.6ml/, and administration was positioned over two groups of mices respectively in the glass cabinet after 0.5 hour, and linking to each other with the Tobacco Control device by rubber tube continues input cigarette smoke and oxygen in cabinet with the negative pressure form, observes 2.5 hours, and the result is as follows:

S group reaction T group reaction 1-6 prop up cigarette suck the 7th cigarette of normal normal suck animal concentrate on outlet flue disperse around quiet the 15th cigarette suck and close one's eyes more; Nose ear tail is congested obviously opens eyes more, and congested not obvious the 25th cigarette sucks 95-120 time/minute the 27th cigarette of 120-140 time/minute breathing of breathing and suck dead 1 no dead the 30th cigarette and suck dead 2 dead 1 the 39th cigarettes and suck 6 of dead 3 dead 1 death toll (rate) (60%) 2 (20%)

The death of S group all shows as after spasm is twitched several times dead immediately, meets the performance of tobaccoism symptom, and that T organizes dead above-mentioned symptom is not obvious, almost is the deep coma peace and quiet entirely, and respiratory arrest death considers to be mainly that CO poisons and the etherization effect causes.

Result of the test shows that simple smoking group mouse death rate is 60%, apparently higher than 20% of smoking+administration group, observes and tests from smoking process, and not administration group mice is subjected to the cigarette injury obviously serious than the administration group.This test proves that once more aloe composition of the present invention truly has the effect of removing toxicity of cigarette, irritates stomach and may impel this factor of T group dead mouse as considering ether, and T group mice situation can be better, illustrates that more said composition has the relieving tabacism effect.

Be subjective symptoms before and after one group of smoker takes medicine below: after taking medicine before day length of smoking case age, the smoking jacket dose was taken medicine

(year) (year) (propping up) (ml) case 1 46 20 20 500 pharyngodynia with drynesss obviously alleviates

Hypopnea

Tasteless case 2 43 20 20 950 larynxs of smoking are done asthma symptom uncomfortable in chest and are eliminated

The black Huang of energetic case 3 58 30 30 1000 complexions is clearly better

The have sore throat case 5 42 250 chronic tracheitis patient inflammation that are clearly better of not good case 4 23 passive smokings 250 of diet alleviate

Breathe smooth and easy

This result shows, aloe composition of the present invention all has in various degree therapeuticing and health effect preferably to smoker, involuntary smoker and tracheitis patient.

Aloe composition of the present invention adds other adjuvant material, can be made into different food products such as chewing gum mouth cream, tea, fruit jelly, electuary, capsule, offers the smoker and the involuntary smoker makes health food.

Effective dose is first smoker: contain aloe composition amount 80-150 gram/day, the length of smoking elder: contain amount of composition 150-250 gram/day, every day, amount was taken at twice.

Compositions of the present invention makes by following process:

1, Folium Apocyni Veneti, Herba Houttuyniae, Radix Platycodonis, Radix Glycyrrhizae, Radix Ginseng are pulverized;

2, soak repeatedly three times with 90% ethanol, extract supernatant, reclaim ethanol through distillation,

Make precipitate;

3, get Fresh leaf of aloe, get its glue juice,, heat 40 ℃-60 ℃, 15-25 through pulverizing

Minute, add antioxidant, antiseptic, stir after-filtration and get Aloe gel resin juice;

4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel, Oleum menthae, be mixed

Promptly make compositions.

Embodiment 1

1, get Folium Apocyni Veneti 2.5 grams, Herba Houttuyniae 5 grams, Radix Platycodonis 2 grams, Radix Glycyrrhizae 2 grams are pulverized;

2, soak repeatedly three times with overlay capacity with 90% ethanol, each soak time 3 hours is collected

Three supernatant reclaim ethanol fully through distillation, make precipitate;

3, get the Chinese aloe aloe [A.evra L.var chinensis] 75 grams, clean, peeling is got

Its glue juice through pulverizing, is heated 40 ℃ and was kept 15 minutes, adds 0.1 gram sodium benzoate,

Add 0.1 gram V-C, stir after-filtration and get Aloe gel resin juice;

4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 13.5 grams, Oleum menthae 0.1

Ml is mixed and promptly makes compositions;

Embodiment 2

1, gets Folium Apocyni Veneti 150 grams, Herba Houttuyniae 100 grams, Radix Platycodonis 10 grams, Radix Glycyrrhizae 10 grams

Pulverize;

2, soak repeatedly three times with overlay capacity with 90% ethanol, returned when soaking 3 hours at every turn, collect

Three supernatant reclaim ethanol fully through distillation, make precipitate;

3, get the Chinese aloe aloe [A.evra L.var chinensis] 650 grams, clean, peeling,

Get its glue juice,, heat 50 ℃ and kept 20 minutes, add 1 gram sodium benzoate through pulverizing,

Add 1 gram, 16 alkanols, stir after-filtration and get Aloe gel resin juice;

4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 80 grams, Oleum menthae 1ml,

Be mixed and promptly make compositions.

Embodiment 3

1, gets Folium Apocyni Veneti 90 grams, Herba Houttuyniae 100 grams, Radix Platycodonis 5 grams, Radix Glycyrrhizae 5 grams, Radix Ginseng

10 grams are pulverized;

2, soak repeatedly three times with overlay capacity with 90% ethanol, each soak time 3 hours is collected

Three supernatant reclaim ethanol fully through distillation, make precipitate;

3, get Aloe vulgaris [Aloe Vera Limne] 250 grams, clean, its glue is got in peeling

Juice through pulverizing, is heated 60 ℃ and was kept 25 minutes, stirs after-filtration and gets Aloe gel resin juice;

4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 40 grams, be mixed and promptly make group

Compound.

Embodiment 4

1, get Folium Apocyni Veneti 40 grams, Herba Houttuyniae 30 grams, Radix Platycodonis 15 grams, Radix Glycyrrhizae 15 grams are pulverized;

2, soak repeatedly three times with overlay capacity with 90% ethanol, each soak time 3 hours is collected

Three supernatant reclaim ethanol fully through distillation, make precipitate;

3, get Aloe vulgaris [Aloe Vera Limne] 800 grams, clean, its glue is got in peeling

Juice through pulverizing, is heated 55 ℃ and was kept 20 minutes, adds 1 gram sodium benzoate, adds

1 gram, 16 alkanols stir after-filtration and get Aloe gel resin juice;

4, above-mentioned precipitate is mixed with Aloe gel resin juice, add Mel 100 grams, be mixed and promptly make

Compositions.

The preparation of embodiment 5 Aloe Chinese medicinal capsules

Get the compositions that embodiment 2 or 4 makes, add fillers such as starch, be dried to powdery, incapsulate interior bottling.

The preparation of embodiment 6 Aloe Chinese medicine chewing gum

Get the aloe composition that embodiment 3 makes, mix with the chewing gum raw material, chewing gum sugar processing technology is made into chewing gum routinely.

The making of embodiment 7 Aloe Chinese medicine confections

Get arbitrary compositions among the embodiment 1-4, add confection juice, butter, fructose, toffee preparation technology make Aloe Chinese medicine confection routinely.

The preparation that embodiment 8 Aloes are frozen cream

1, gets the aloe composition of embodiment 4;

2, get 5 gram agar, water 100ml soaks after 30 minutes and adds above-mentioned composition;

3, at 80 ℃ of dissolvings 15 minutes of heating, natural cooling;

4, packing, pasteurization, cooling, this makes Aloe and freezes the cream health product.

The preparation of embodiment 9 Aloe tea

1, get the compositions adding Folium Camelliae sinensis of embodiment 3, the weight ratio of compositions and Folium Camelliae sinensis is 3: 1;

2, produce tea bag, piece tea or bulk tea respectively by tea bag, piece tea or bulk tea production technology.

Claims (7)

1, a kind of aloe composition is characterized in that mainly being made by following materials by weight percentage: Fresh leaf of aloe 50%-80%, Folium Apocyni Veneti 2%-20%, Herba Houttuyniae 2%-20%, Radix Platycodonis 1%-2%, Radix Glycyrrhizae 1%-2%, Mel 8%-14%.

2, aloe composition according to claim 1 is characterized in that, the percentage by weight of Fresh leaf of aloe is 65%-75%.

3, the described aloe composition of root a tree name claim 1 is characterized in that, the percentage by weight of Folium Apocyni Veneti is 2.5-4%.

4, aloe composition according to claim 1, it is an amount of to it is characterized in that containing Oleum menthae, to producing the refrigerant sense of taste.

5, aloe composition according to claim 1 is characterized in that containing Radix Ginseng or the Radix Codonopsis or the Radix Pseudostellariae of 1-20% percentage by weight.

According to a kind of described aloe composition among the claim 1-5, it is characterized in that 6, containing antioxidant is the vitamin C of 1 ‰ weight ratios, containing antiseptic is the sodium benzoate of 1 ‰ weight ratios.

7, aloe composition according to claim 6 is characterized in that, aloe composition is equipped with medicine or food acceptable additive, makes mastic, capsule, chewing gum, tea or confection.