CN107320533A - A kind of Chinese medicine composition for preventing chicken to catch - Google Patents
A kind of Chinese medicine composition for preventing chicken to catch Download PDFInfo
- Publication number
- CN107320533A CN107320533A CN201710681535.3A CN201710681535A CN107320533A CN 107320533 A CN107320533 A CN 107320533A CN 201710681535 A CN201710681535 A CN 201710681535A CN 107320533 A CN107320533 A CN 107320533A
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- CN
- China
- Prior art keywords
- extract
- jia betel
- fructus elaeagni
- chinese medicine
- medicine composition
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
Abstract
It is 21 the present invention relates to the weight ratio of a kind of Chinese medicine composition for preventing chicken to catch, by Fructus Elaeagni extract He Jia Betel extracts are constituted, Fructus Elaeagni extract He Jia Betel extracts:1‑5.The present invention is also claimed to expect to mix the application fed by above-mentioned Chinese medicine composition with other feedings.Proved through experimental study, Fructus Elaeagni extract is used in combination Yu Jia Betel extracts with specific part by weight, and synergy is obvious, evident in efficacy, with low cost；Using antibiotic need not be reused after the present invention can be achieved the purpose of prevention and control E.coli from chickens infectious disease and checken pest.
Description
Technical field
The invention belongs to livestock rearing technical field, more particularly to a kind of Chinese medicine composition for preventing chicken to catch, use
Caused disease, and anti-checken pest are infected by ETEC in treatment chicken.
Background technology
It is increasingly serious with the various environmental pollutions such as atmosphere pollution, water pollution, because of reasons such as breeding environment differences, cause house
Poultry, the health of poultry occur in that various problems, therefore the phenomenon of the antibiotic medicine of addition overdose is very universal in feed.
The resistance against diseases for how to regulate breeding environment, solving and improve livestock and poultry, improves herd immunity and improves the productivity of livestock and poultry
The focus of research can be turned into.The abuse of antibacterials makes bacterium generate antibody-resistant bacterium, in animal body and products thereof in have
The medicament residue of inequality, the health of the mankind also cannot be guaranteed.The frequent intake of the antibiotic residues of low dosage, tires out year by year
Building up in vivo for the moon, causes the mankind to suffer from more diseases.Influence of the residue of antibiotic to human body is mainly manifested in
Can occur the effect such as allergic reaction, immunosupress, teratogenesis, carcinogenic, mutagenesis.Bacterial drug resistance is always the focus of global concern
Problem, as the abuse of chemical drugs antibiotic and " superbacteria " emerge in an endless stream in world wide, bacterial drug resistance is to the mankind
Harm it is more serious, and have not quenchable trend.Cause in today of chemical drugs antibiotic scarcity relatively, Escherichia coli
Characteristic of disease Escherichia coli can cause many animals ill, clinically may occur in which the symptoms such as yellowish-white dysentery, oedema, septicemia.Therefore, people
Begin look for some Chinese herbal medicines and be used to reverse the drug resistance of antibiotic Western medicine, or attempt to filter out can directly prevent or
Suppress the Chinese herbal medicine of ETEC.
Thorny elaeagnus, alias：The ruined son of Pu, half are containing spring, Lu Douzi, sparrow shortcake, sweet tea ear of maize etc., and Elaeangnaceae, Elaeagnus are normal
Green upright shrub.The equal hyoscine of its root, leaf, fruit, also certain ornamental value.Thorny elaeagnus main chemical compositions have volatilization
Oil, terpene, alkaloid, flavones etc.；Pharmacological activity mainly has hypoglycemic, reducing blood lipid, lipid peroxidation inhibition, anti-inflammatory and antalgic, immune etc..
Jia Betel (scientific names：Piper sarmentosum Roxb.), also known as clam beach wormwood, false beach wormwood, mountain beach wormwood etc., it is Piperaceae pepper
Platymiscium.False Betel originates in Chinese Guangdong, Guangxi, Fujian, Yunnan, Guizhou and Tibet (Motuo) each provinces and regions, is born in by sylvan life or village
On wetland.Jia Betel are pungent, warm-natured, nontoxic.It is pharmaceutically acceptable, radical cure treating rheumatic ostealgia, traumatic injury, cough due to wind-cold evil, gestation and postpartum water
Swell；Also edible, people are usually cooked with its leaf, and its delicious food is often mentioned in the same breath with purple perilla.False Betel stems, Ye Shui
Immersion liquid has inhibitory action to staphylococcus aureus, shigella flexneri etc.., Jia Betel also have antipyretic-antalgic, anti-inflammatory, drop simultaneously
The effect such as bone healing after hypoglycemia, anti-oxidant and promotion fracture.The report acted at present on Jia Betel extracts killing pests and suppressing bacteria
Road is less, and Chinese Patent Application No. 2009102358119 discloses a kind of Jia Betel extracts and its in killing pests and suppressing bacteria agent is prepared
Application, it has good preventing and treating to prodenia litura, roadway caving mining, radish aphid, bajiao banana anthrax bacteria and rubber anthrax bacteria
Effect.
Through retrieval, do not inquire thorny elaeagnus He Jia Betel combine for treating chicken caused by ETEC infection
The relevant report of disease.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for preventing chicken to catch, it acts synergistically
Substantially, it is not necessary to reuse the purpose that prevention and control E.coli from chickens infectious disease and checken pest can be achieved in antibiotic.
To solve above technical problem, the present invention uses following technical scheme：A kind of Chinese medicine group for preventing chicken to catch
Compound, by Fructus Elaeagni extract He Jia Betel extracts are constituted, Fructus Elaeagni extract is He the weight ratio of Jia Betel extracts is 2-1:1-
5。
The present invention is also claimed to expect to mix the application fed by above-mentioned Chinese medicine composition with other feedings.
Fructus Elaeagni extract of the present invention is He the preparation method of Jia Betel extracts is as follows：
(the preparation method of 1) Jia Betel extracts：Jia Betel are cleaned, dried in the shade, are crushed with pulverizer, 40-60 mesh sieves is crossed, obtains powder
Mince；In gained crushed material according to weight than add 5-10 times measure 95% ethanol, soaking at room temperature 24-48h after, carried with ultrasonic wave
30-60min is taken, then with filtered on buchner funnel, collects filtrate, is extracted 2-3 times with method, merges all filtrates；Then steamed with rotation
Hair instrument is concentrated under reduced pressure into relative density and is 1.10-1.20 paste, then is freeze-dried into powder, that is, Jia Betel extracts are made.
(2) preparation method of Fructus Elaeagni extract is with (the preparation method of 1) Jia Betel extracts.
The beneficial effect that the present invention possesses is：It is of the invention to be proved through experimental study, Fructus Elaeagni extract Yu Jia Betel extracts
It is used in combination with specific part by weight, synergy is obvious, evident in efficacy, with low cost；Using need not be again after the present invention
It is the purpose that prevention and control E.coli from chickens infectious disease and checken pest can be achieved using antibiotic.
Embodiment
Technical scheme and beneficial effect are described further with reference to specific embodiment, this embodiment
The thorny elaeagnus used is the root of thorny elaeagnus, leaf , Jia Betel Wei Jia Betel root, stem, leaf.
First, Fructus Elaeagni extract is Yu Jia Betel extracts are to the measure of ETEC synergy
1. Fructus Elaeagni extract is He the preparation method of Jia Betel extracts is as follows：
(the preparation method of 1) Jia Betel extracts：Jia Betel are cleaned, dried in the shade, are crushed with pulverizer, 50 mesh sieves is crossed, must crush
Thing；In gained crushed material ultrasonic wave extraction is used according to weight than adding after 10 times of 95% ethanol of amount, soaking at room temperature 36h
45min, then with filtered on buchner funnel, filtrate is collected, extracted 2 times with method, merge all filtrates；Then depressurized with Rotary Evaporators
It is concentrated into relative density and is 1.15 paste, then be freeze-dried into powder, that is, Jia Betel extracts is made.
(2) preparation method of Fructus Elaeagni extract：With (the preparation method of 1) Jia Betel extracts.
2. test medicine
(1) Fructus Elaeagni extract single dose；
(2) Jia Betel extract single doses；
(3) Fructus Elaeagni extract Yu Jia Betel extracts first compare 4 according to weight:1 mixing, obtains mixture 1#；
(4) Fructus Elaeagni extract Yu Jia Betel extracts first compare 3 according to weight:1 mixing, obtains mixture 2#；
(5) Fructus Elaeagni extract Yu Jia Betel extracts first compare 2 according to weight:1 mixing, obtains mixture 3#；
(6) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:1 mixing, obtains mixture 4#；
(7) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:2 mixing, obtain mixture 5#；
(8) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:3 mixing, obtain mixture 6#；
(9) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:4 mixing, obtain mixture 7#；
(10) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:5 mixing, obtain mixture 8#；
(11) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:6 mixing, obtain mixture 9#；
(12) Fructus Elaeagni extract Yu Jia Betel extracts first compare 1 according to weight:7 mixing, obtain mixture 10#.
(13) concentration is 10mg/g Amoxicillin decoction.
3. subjects：The ETEC of chicken infection.
4. test method：
MIC of each medicament to ETEC is determined using liquid coubling dilution.
Above-mentioned 13 kinds of medicaments, every kind of medicament takes 7 test tubes respectively, numbering 1-7, and every loads 1ml broth bouillons.
Above-mentioned test medicine is separately added into each No. 1 test tube so that Fructus Elaeagni extract, Jia Betel extracts and mixture 1#-
10# initial concentration is 200mg/ml, and the initial concentration of Amoxicillin is 5mg/ml；After No. 1 test tube is well mixed, 1ml is taken
Mixed liquor is drawn 1ml mixed liquors to No. 6 test tubes by that analogy and cast out, complete doubling dilution to No. 2 test tubes；No. 7 test tubes are to be not added with
The blank control of medicine.
It is 10 to add bacteria containing amount in the cultured E bacteria suspensions of 0.1ml, suspension to every test tube5CFU/ml。
Whole test tubes are placed in 37 DEG C, 24h are cultivated on 120r/min shaking table, the least concentration for not occurring muddiness is the medicament to big
The MIC of intestines Escherichia.
5. result of the test
MIC measurement result of each medicament to ETEC
Note："+" represents that long bacterium is muddy in upper table；"-" represents that not long bacterium does not occur muddiness.
As seen from the above table, Fructus Elaeagni extract Ji Jia Betel extracts be respectively to the MIC of ETEC 50mg/ml,
200mg/ml.And in the mixture, mixture 1#, 9# MIC are 200mg/ml；Mixture 10# MIC is more than 200mg/ml,
Illustrate that Fructus Elaeagni extract Yu Jia Betel extracts compare 4 according to weight:1、1:6、1:7 mixing, show as antagonism.
Mixture 3#- mixtures 8# MIC is reduced to 12.5mg/ml, shows obvious synergy；With Western medicine Ah Moses
Woods 1.25mg/ml effects are suitable.
2nd, Fructus Elaeagni extract is Yu the experiment in vitro that Jia Betel extracts are used in combination
By Fructus Elaeagni extract He Jia Betel extracts are 1 according to weight ratio:3 mixing are used as test group；Separately thorny elaeagnus is set to carry
Thing single dose is taken Ji Jia Betel extracts single dose as a control group 1 and control group 2.
1. treat the experiment of E.coli from chickens disease
Subjects：Make a definite diagnosis the chicken group for having infected E.coli from chickens disease.
Test method：Morbidity chicken group is divided into 3 groups, test group is carried according to per kilogram coarse food grain feeding material addition 60g thorny elaeagnus
Thing is taken He the mixture of Jia Betel extracts is fed；Control group 1 is extracted according to per kilogram coarse food grain feeding material addition 60g thorny elaeagnus
Thing single dose is fed；Control group 2 is fed according to per kilogram coarse food grain feeding material addition 60g Jia Betel extract single doses；It is described
Coarse food grain feeding material is corn flour, the mixture of green vegetables；Each group is persistently fed 7 days.
Result of the test：The diseased chicken feed intake of test group increased, no death, all be fully recovered using chicken group after 7 days；Control
The most of still wans of chicken group of group 1, have 3% diseased chicken dead；It is also still wan that chicken group of control group 2 is most of, there is 5%
Diseased chicken it is dead.
2. treat checken pest experiment
According to per kilogram coarse food grain feeding material addition 60g Fructus Elaeagni extracts He the mixture of Jia Betel extracts is fed,
Monthly at least 3 times, checken pest epizootic modeling, which is monthly fed, to be risen to 6-9 times；So far the method for breeding is implemented 4 years, is not always had
Occurred checken pest.
Claims (2)
1. a kind of Chinese medicine composition for preventing chicken to catch, it is characterised in that by Fructus Elaeagni extract He Jia Betel extract groups
Into Fructus Elaeagni extract is He the weight ratio of Jia Betel extracts is 2-1:1-5.
2. Chinese medicine composition according to claim 1 mixes the application fed with other feeding material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710681535.3A CN107320533A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicine composition for preventing chicken to catch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710681535.3A CN107320533A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicine composition for preventing chicken to catch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107320533A true CN107320533A (en) | 2017-11-07 |
Family
ID=60199452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710681535.3A Withdrawn CN107320533A (en) | 2017-08-10 | 2017-08-10 | A kind of Chinese medicine composition for preventing chicken to catch |
Country Status (1)
| Country | Link |
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| CN (1) | CN107320533A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107373073A (en) * | 2017-08-10 | 2017-11-24 | 广西南宁乐蕊生物科技有限责任公司 | One breeder feeding material |
-
2017
- 2017-08-10 CN CN201710681535.3A patent/CN107320533A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107373073A (en) * | 2017-08-10 | 2017-11-24 | 广西南宁乐蕊生物科技有限责任公司 | One breeder feeding material |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20171107 |
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| WW01 | Invention patent application withdrawn after publication |