CN111012823A - Medicine containing lindera glauca volatile oil and administration method thereof - Google Patents

Medicine containing lindera glauca volatile oil and administration method thereof Download PDF

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CN111012823A
CN111012823A CN202010084592.5A CN202010084592A CN111012823A CN 111012823 A CN111012823 A CN 111012823A CN 202010084592 A CN202010084592 A CN 202010084592A CN 111012823 A CN111012823 A CN 111012823A
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volatile oil
medicine
lindera glauca
glauca
administration method
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Inventor
刘胜贵
王钲霖
马海悦
付彬彬
李智高
孔令羽
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Yunnan Luxin Biopharmaceutical Co ltd
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Yunnan Luxin Biopharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
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  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
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  • Medical Informatics (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

The invention provides a medicine containing lindera glauca volatile oil and a drug delivery method thereof, wherein the medicine comprises the following components (by mass percent) 1-10% of lindera glauca volatile oil and 90-99% of glycerol. The invention utilizes the electronic atomizer as a dosing instrument, accurately sets reasonable heating temperature (300-1000 ℃), and vaporizes the volatile oil medicament when the heating temperature exceeds the boiling point of compounds in the volatile oil through the heating action of the atomizer, so that a patient sucks medicament gas into an oral cavity and enters a respiratory tract in a smoking way, thereby exerting the curative effect of the medicament. The medicine of the present invention has the functions of relieving cough, eliminating phlegm and relieving asthma, and can be used for treating chronic bronchitis.

Description

Medicine containing lindera glauca volatile oil and administration method thereof
Technical Field
The invention relates to a medicine, in particular to a medicine containing lindera glauca volatile oil and an administration method thereof.
Background
Chronic bronchitis is a chronic nonspecific inflammation of the trachea, bronchial mucosa and surrounding tissues, mainly due to the formation of bronchial chronic nonspecific inflammation by repeated infection with viruses and bacteria. The clinical symptoms mainly include cough, expectoration or asthma lasting for more than 3 months every year after 2 or more years, which are common diseases of respiratory system and are serious health hazards. With the gradual deterioration of environmental pollution and the increasing of smoking population in recent years, the incidence rate of chronic bronchitis worldwide tends to rise year by year, and if the chronic bronchitis is not treated in time, the chronic bronchitis may develop into chronic obstructive pulmonary diseases and even pulmonary heart diseases, which seriously affect the life quality of patients.
Clinically, recurrent attacks are a major feature of chronic bronchitis, and the treatment is mainly symptomatic treatment, i.e., cough relieving, phlegm reducing, asthma relieving, and the like. The atomization treatment is also a treatment means which is commonly used in clinic, but a glucocorticoid medicament is often used, the medicament has large side effect, the atomization treatment can be carried out only by a professional medical institution, and patients with less serious symptoms can be aggravated because of unwilling to go to a hospital. Once the chronic bronchitis is ill, the chronic bronchitis is difficult to completely cure, and no radical cure is available for the modern medical treatment of the chronic bronchitis, so that the development of a new medicine and a new administration route are very important.
Plant essential oils, also known as essential oils, are a general term for essential oils that are present in different tissues of plants, can be distilled with water vapor and have a certain specific and strong odor. Many plant essential oils have the effects of resisting bacteria and diminishing inflammation, relieving fever and pain, calming the nerves, resisting tumors and the like, and are safe and less in toxic and side effects. There are historical data showing that essential oils of plants are useful for treating diseases in folk from Ming dynasty.
According to records in Chinese herbal medicine dictionary, the spicebush has the effects of expelling wind and removing cold, regulating qi and killing parasites, detoxifying and relieving pain, relieving asthma, resisting allergy, arrhythmia, fungi and viruses and degrading aflatoxin, and is a common folk medicine. The lindera glauca volatile oil has broad-spectrum inhibition on bacterial growth, and has good inhibition effect on various bacteria such as escherichia coli, proteus, typhoid bacillus, pseudomonas aeruginosa, staphylococcus aureus, bacillus subtilis, pseudomonas aeruginosa, salmonella, diplococcus pneumoniae, staphylococcus albus and the like; the lindera glauca volatile oil can also inhibit inflammation, has anti-inflammatory and antiallergic effects, and is clinically used for treating chronic inflammation; the main component citral in the lindera glauca volatile oil can relieve cough and eliminate phlegm, can obviously relax tracheal and intestinal smooth muscles, has obvious asthma relieving effect, and is a main research object for developing a medicine for relieving bronchitis. The citral also has strong lemon fragrance and antioxidant activity, so the volatile oil of fructus Piperis can be used as flavoring agent and antiseptic.
The electronic atomizer makes the battery work through the air current response or switch button, and the intercommunication atomizer heats evaporation liquid to produce atomization effect.
Disclosure of Invention
The invention aims to provide a medicine containing lindera glauca volatile oil and capable of relieving cough, eliminating phlegm and relieving asthma, and the medicine can be used for treating chronic bronchitis. Meanwhile, a new administration method is provided, an electronic atomizer is used as an administration instrument, reasonable heating temperature is accurately set, volatile oil medicine is vaporized through the heating effect of the atomizer, and the medicine gas is sucked into the oral cavity and enters the respiratory tract by a patient in a smoking mode, so that the curative effect of the medicine is exerted.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a medicine containing lindera glauca volatile oil and an administration method thereof are disclosed, wherein the medicine comprises the following components (by mass percentage) 1-10% of lindera glauca volatile oil and 90-99% of glycerol.
In the invention, the lindera glauca volatile oil is prepared by extracting lindera glauca fruits by a steam distillation method, and the glycerol is medicinal grade.
In the invention, the method comprises the following steps:
① extraction of volatile oil of fructus Piperis is carried out by placing 100g of grinded fructus Piperis into 1000 mL round-bottom flask, adding 500mL deionized water, soaking for 1-2 h, installing steam distillation device, collecting extracted volatile oil after about 5h, adding appropriate amount of anhydrous sodium sulfate into the obtained volatile oil, dehydrating to obtain light yellow transparent liquid with strong fragrance, namely volatile oil of fructus Piperis, and storing in refrigerator for later use.
② the preparation method comprises weighing raw materials according to a certain weight ratio, adding the volatile oil into glycerol solution, stirring, and mixing.
The administration mode of the medicine of the invention is as follows: the electronic atomizer is used as a medicine feeding instrument, reasonable heating temperature is accurately set, volatile oil medicine is vaporized through the heating effect of the atomizer, and medicine gas is sucked into an oral cavity and enters a respiratory tract by a patient in a smoking mode, so that the curative effect of the medicine is exerted.
The advantages of the invention are as follows:
① the volatile oil of fructus Piperis is natural extract, safe and has no adverse side effects.
② the volatile oil of fructus Piperis is effective in relieving cough, eliminating phlegm, and relieving asthma, and can be used for symptomatic treatment of chronic bronchitis.
③ the volatile oil of fructus Piperis is effective in inhibiting pathogenic bacteria, resisting inflammation and allergy, reducing antibiotic and glucocorticoid consumption, and reducing side effects.
④ the volatile oil of fructus Piperis has strong lemon fragrance and antioxidant activity, and has good patient acceptance and easy storage.
⑤ the invention provides a new drug delivery method based on the medical atomization treatment principle, and the drug delivery instrument has the advantages of small dosage, large absorption surface area, and rapid effect.
Detailed Description
The present invention is further illustrated by, but is not limited to, the following examples.
Example 1
(1) Extracting the volatile oil of the wild pepper: placing 100g of ground wild pepper fruits in a 1000 mL three-neck round-bottom flask, adding 500mL deionized water, soaking for 1-2 h, installing a steam distillation device, collecting extracted volatile oil after about 5h, adding a proper amount of anhydrous sodium sulfate into the obtained volatile oil, dehydrating to obtain light yellow transparent liquid with strong fragrance, and storing in a refrigerator for later use.
(2) Preparing 100g of medicine, weighing 1g of lindera glauca volatile oil and 99 g of glycerol, melting the lindera glauca volatile oil into a glycerol solution, fully stirring, and subpackaging.
Example 2
(1) Extracting the volatile oil of the wild pepper: placing 100g of ground wild pepper fruits in a 1000 mL three-neck round-bottom flask, adding 500mL deionized water, soaking for 1-2 h, installing a steam distillation device, collecting extracted volatile oil after about 5h, adding a proper amount of anhydrous sodium sulfate into the obtained volatile oil, dehydrating to obtain light yellow transparent liquid with strong fragrance, and storing in a refrigerator for later use.
(2) Preparing 100g of medicine, weighing 5g of lindera glauca volatile oil and 95g of glycerol, melting the lindera glauca volatile oil into a glycerol solution, fully stirring and uniformly mixing, and subpackaging.
Example 3
(1) Extracting the volatile oil of the wild pepper: placing 100g of ground wild pepper fruits in a 1000 mL three-neck round-bottom flask, adding 500mL deionized water, soaking for 1-2 h, installing a steam distillation device, collecting extracted volatile oil after about 5h, adding a proper amount of anhydrous sodium sulfate into the obtained volatile oil, dehydrating to obtain light yellow transparent liquid with strong fragrance, and storing in a refrigerator for later use.
(2) Preparing 100g of medicine, weighing 10g of lindera glauca volatile oil and 90g of glycerol, melting the lindera glauca volatile oil into a glycerol solution, fully stirring and uniformly mixing, and subpackaging.
Example 4 Effect evaluation test for treating Chronic bronchitis
(1) Experimental articles: the medicaments were prepared as in the examples.
(2) Subject: 150 patients with chronic bronchitis were divided into three groups of 50 persons, and the drugs of examples 1, 2 and 3 were tried. The electronic atomizer is used as an administration instrument, the heating temperature of the atomizer is set to be 300 ℃, volatile oil medicine is vaporized by heating of the atomizer, and a patient sucks medicine gas into an oral cavity in a smoking mode to enter the body. The composition is used twice a day when symptoms such as cough, phlegm, asthma and the like appear, adverse reaction statistics and drug evaluation are carried out after three months, and the results are shown in tables 1 and 2.
TABLE 1 adverse drug reactions statistics
Figure 194439DEST_PATH_IMAGE002
TABLE 2 evaluation of drug Effect
Figure DEST_PATH_IMAGE004
(3) The medicine containing the lindera glauca volatile oil has less adverse reaction and higher effective rate, which shows that the medicine can effectively relieve cough, eliminate phlegm and relieve asthma, and can be used for treating chronic bronchitis.
The above description is only a detailed description of specific embodiments of the present invention, and should not be taken as limiting the invention, and any modifications, equivalents, improvements, etc. made on the design concept of the present invention should be included in the protection scope of the present invention.

Claims (4)

1. A medicine containing lindera glauca volatile oil and an administration method thereof are characterized in that the medicine comprises the following components (by mass percent) 1-10% of lindera glauca volatile oil and 90-99% of glycerol.
2. The medicine containing the lindera glauca volatile oil and the administration method thereof as claimed in claim 1, wherein the lindera glauca volatile oil is extracted from the fruit of lindera glauca by steam distillation, and glycerol is pharmaceutical grade.
3. The medicine containing the lindera glauca volatile oil and the administration method thereof as claimed in claim 1, wherein the extraction method of the lindera glauca volatile oil comprises the following steps:
(1) extracting the volatile oil of the wild pepper: placing 100g of ground wild pepper fruits in a 1000 mL three-neck round-bottom flask, adding 500mL deionized water, soaking for 1-2 h, installing a steam distillation device, collecting extracted volatile oil after about 5h, adding a proper amount of anhydrous sodium sulfate into the obtained volatile oil, dehydrating to obtain light yellow transparent liquid with strong fragrance, namely the wild pepper volatile oil, and storing in a refrigerator for later use;
(2) weighing the raw materials according to a certain mass fraction, melting the lindera glauca volatile oil into a glycerol solution, and fully stirring and uniformly mixing.
4. The medicine containing the lindera glauca volatile oil and the administration method thereof as claimed in claim 1, wherein the administration mode is: the electronic atomizer is used as an administration instrument, reasonable heating temperature (300-1000 ℃) is accurately set, the volatile oil medicine is vaporized under the heating action of the atomizer when the heating temperature exceeds the boiling point of compounds in the volatile oil, and a patient sucks medicine gas into an oral cavity in a smoking mode and enters a respiratory tract, so that the curative effect of the medicine is exerted.
CN202010084592.5A 2020-02-10 2020-02-10 Medicine containing lindera glauca volatile oil and administration method thereof Pending CN111012823A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023286977A1 (en) * 2021-07-12 2023-01-19 주식회사 프롬바이오 Anti-allergic composition using water-solubilized mastic gum or lindera glauca blume extract

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
万顺康等: "山胡椒挥发油化学成分的研究", 《时珍国医国药》 *
张小云等: "山胡椒挥发油的提取及其抑菌活性研究", 《现代生物医学进展》 *
徐传快: "《烟草密码》", 31 October 2015, 中国发展出版社 *
游玉明: "山胡椒挥发油抑菌活性的研究", 《重庆文理学院学报(自然科学版)》 *
游玉明等: "山胡椒果实挥发油化学成分的GC-MS分析", 《食品研究与开发》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023286977A1 (en) * 2021-07-12 2023-01-19 주식회사 프롬바이오 Anti-allergic composition using water-solubilized mastic gum or lindera glauca blume extract

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