CN114984121B - A Chinese medicinal composition with effects of refreshing and relieving fatigue, and its preparation method and application - Google Patents
A Chinese medicinal composition with effects of refreshing and relieving fatigue, and its preparation method and application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses an aromatic refreshment and anti-fatigue traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of grassleaf sweelflag rhizome, 1-6 parts of dalbergia wood and 1-6 parts of nardostachys root. The traditional Chinese medicine composition provided by the invention can effectively reduce the sleep rate, prolong the sleep latency period and shorten the sleep duration, and has the effects of aromatic refreshment and fatigue resistance.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition with aromatic refreshment and fatigue resistance, and a preparation method and application thereof.
Background
In modern society, with the increase of life pressure, students and office workers easily cause fatigue and drowsiness due to overlong mental labor time, and have bad consequences such as unclear thinking, disordered thinking, low working efficiency and the like. People often drink beverages such as coffee and strong tea to refresh their mind, but these beverages are extremely prone to cause dependence and adverse symptoms such as insomnia. In this case, researchers have tried aromatic traditional Chinese medicines to achieve the effects of refreshing and relieving fatigue. The aromatherapy is a natural therapy which takes aromatic plants to form single or compound volatile oil as a medium, and acts on local or whole body by means of sniffing, massage, oral administration, fumigation and the like on the premise of safety so as to achieve the effects of conditioning skin, balancing emotion and preserving health.
Various health care products or medicines for refreshing and relieving fatigue which are sold in the market at present can play a temporary refreshing role, but can not radically relieve fatigue, have slower effect and can not obtain good refreshing effect; in addition, the prior art has little research on the use of aromatic traditional Chinese medicines for refreshing and eliminating fatigue.
Disclosure of Invention
In view of the above technical problems, the present invention provides the following technical solutions:
the invention provides an aromatic refreshment and anti-fatigue traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of grassleaf sweelflag rhizome, 1-6 parts of dalbergia wood and 1-6 parts of nardostachys root.
Preferably, the feed comprises the following raw materials in parts by weight: 2 parts of storax, 2 parts of grassleaf sweelflag rhizome, 1 part of dalbergia wood and 1 part of nardostachys root.
Preferably, the feed comprises the following raw materials in parts by weight: 2 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root.
Preferably, the feed comprises the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root.
The invention also provides a preparation method of the aromatic refreshment and anti-fatigue traditional Chinese medicine composition, which comprises the following steps: weighing storax, grassleaf sweelflag rhizome, rosewood heart wood and nardostachys root in parts by weight, mixing, and extracting volatile oil.
Preferably, the extraction is by steam distillation, low polarity organic solvent extraction, carbon dioxide fluid extraction or supercritical CO 2 One of the extractions.
Preferably, the supercritical CO 2 The specific process parameters of the extraction are set as follows: the extraction temperature is 35-60 ℃, the extraction pressure is 30-35MPa, the extraction time is 120-180min, and the dosage of entrainer is 10%.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicament for refreshing.
The invention also provides a Chinese medicinal preparation with the effects of aromatic refreshment and fatigue resistance, which comprises the Chinese medicinal composition and pharmaceutically acceptable auxiliary materials or carriers.
Preferably, the Chinese medicinal preparation is aerosol, nasal spray or nasal suppository.
The Chinese medicinal composition for refreshing and resisting fatigue provided by the invention has the advantages that storax and grassleaf sweelflag rhizome in the formula are fragrant and pungent in temperature, are products for inducing resuscitation, avoiding dirt and refreshing, have strong fragrance and promoting dispersion, have the effects of refreshing and invigorating brain, eliminating dampness and harmonizing stomach, and tranquilizing and benefiting mind, and are monarch drugs in the formula; the rosewood heart has the effects of 'moving away fragrance and guiding medicine upwards', and the spikenard can prevent excessive dryness of prodrug, has the effects of tonifying, harmonizing and slowing, and is used as adjuvant medicine. The medicines are combined together to play the roles of avoiding dirt, preventing sense, inducing resuscitation and restoring consciousness.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition provided by the invention comprises the raw materials containing volatile oil components such as storax, grassleaved sweetflag rhizome, rosewood, nardostachys root and the like, can effectively reduce the sleep rate, prolong the sleep latency period and shorten the sleep duration after being matched with a specific dosage, and has the effects of aromatic refreshment and fatigue resistance.
2. The traditional Chinese medicine composition provided by the invention has the characteristics of no toxicity and long-term use, opens up a new field for clinical application of a new medicinal or health care function of the aromatic traditional Chinese medicine composition, and has a wide market prospect.
Detailed Description
The invention provides a traditional Chinese medicine composition and application thereof in preparing a medicament for refreshing brain, and a person skilled in the art can refer to the content of the traditional Chinese medicine composition and properly improve the technological parameters. It is expressly noted that all such similar substitutions and modifications will be apparent to those skilled in the art, and are deemed to be included in the present invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those skilled in the relevant art that the invention can be practiced and practiced with modification and alteration and combination of the methods and applications herein without departing from the spirit and scope of the invention.
The invention provides an aromatic refreshment and anti-fatigue traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 2-9 parts of storax, 2-9 parts of grassleaf sweelflag rhizome, 1-6 parts of dalbergia wood and 1-6 parts of nardostachys root.
The storax, the grassleaf sweelflag rhizome, the rosewood heart and the nardostachyos are all aromatic medicines, the aromatic medicines are small in general molecules, can easily permeate the blood brain barrier, and meanwhile, the permeability of the blood brain barrier is increased, so that other medicines are accumulated in the brain after passing through the blood brain barrier. Research shows that aromatic resuscitation drugs can open the blood brain barrier by changing the ultrastructure of the blood brain barrier and affecting the function of P-glycoprotein; or to regulate the level of certain neurotransmitters such as dopamine, 5-hydroxytryptamine to affect nerve impulses; or the concentration of the aromatic medicine has dual functions of exciting or inhibiting the center, thereby realizing the efficacy of inducing resuscitation and restoring consciousness.
The invention is further illustrated by the following examples:
example 1
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root.
The composition is prepared according to the following method:
weighing storax, rhizoma Acori Graminei, lignum Dalbergiae Odoriferae and rhizoma Nardostachyos, drying, pulverizing, sieving, weighing, charging, extracting with supercritical CO2 (extraction conditions of 55deg.C, extraction pressure 30MPa, extraction time 120min and entrainer amount 10%), and vacuum separating to obtain volatile oil.
Example 2
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 2 parts of storax, 2 parts of grassleaf sweelflag rhizome, 1 part of dalbergia wood and 1 part of nardostachys root.
The preparation method is the same as in example 1.
Example 3
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 3 parts of storax, 2 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root.
The preparation method is the same as in example 1.
Example 4
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 2 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root.
The preparation method is the same as in example 1.
Example 5
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 9 parts of storax, 9 parts of grassleaf sweelflag rhizome, 6 parts of dalbergia wood and 6 parts of nardostachys root.
The preparation method is the same as in example 1.
Comparative example 1
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 3 parts of storax, 2 parts of dalbergia wood and 2 parts of rhizoma nardostachyos.
The preparation method is the same as in example 1.
Comparative example 2
The Chinese medicinal composition for aromatic refreshment and fatigue resistance comprises the following raw materials in parts by weight: 3 parts of grassleaf sweelflag rhizome, 2 parts of rosewood, and 2 parts of nardostachys root.
The preparation method is the same as in example 1.
Experimental example 1
Allergy test
Whether the animal respiratory system is stimulated or not is explored, so that guinea pigs are used as experimental animals, the smell of the guinea pigs is developed, the guinea pigs are easy to allergic, the study on drug allergy and antiasthmatic drugs is commonly used, and the allergic symptoms of the guinea pigs are classified into five grades:
guinea pigs do not show any symptoms and are normal, marked by anaphylactic strength "-" and score "0", and anaphylactic reaction is judged as "negative";
the guinea pigs have symptoms of restlessness, hair erection, trembling and nose scratching, marked as allergic strength "+" and score "1", and the allergic reaction is judged as weak positive;
the symptoms of sneeze, cough, shortness of breath, urination, defecation and lacrimation of the guinea pigs are marked as allergic intensity "++", score "2", and the allergic reaction is judged as positive;
the guinea pigs have dyspnea, wheezing, purpura, gait instability, jumping, wheezing, cramping, rotation and tidal breathing symptoms, which are marked as allergic strength "++", score "3", and allergic response is judged as strong positive;
the death of the guinea pigs occurred, the sensitivity is marked as "+++", scoring "4", allergic reactions were judged as "extremely positive".
The Chinese medicinal compositions of examples 1-5 and comparative examples 1-2 were inhaled by aerosol into each group of guinea pigs (8 in each group), taken out after 15min, the state 15min before spraying and the state 15min after spraying were recorded, the plastic box was washed, the above steps were repeated after the odor in the box disappeared, and pure water was used as a normal control group. The above procedure was repeated every other day and the experiment was repeated 3 times.
The allergic symptoms of each group of guinea pigs are shown in Table 1.
TABLE 1 allergy intensity of guinea pigs of each group
Experimental example 2
Randomly selecting 8 groups of healthy mice (8 mice in each group), respectively placing the healthy mice in a transparent plastic box filled with the formula aerosol for 15min, taking out the healthy mice and placing the healthy mice in the air for 15min, and continuously administering the healthy mice for 7 days, wherein the healthy mice are administered 1 time a day. After the last administration for 30min, sodium pentobarbital (50 mg/kg) was administered, and the sleep latency and sleep time were measured using the occurrence rate of regular reflection (i.e., falling asleep rate) as an index, and pure water was used as a normal control group.
The experimental results are shown in Table 2.
TABLE 2 influence of groups on the sleep time of mice by pentobarbital
Note that: with the sodium pentobarbital group, Δ p is less than 0.05; in contrast to comparative example 1, # p is less than 0.05; in contrast to comparative example 2, * P＜0.05。
the above results illustrate: the traditional Chinese medicine composition provided by each embodiment group has obvious refreshing function, and compared with the tested medicines (namely each comparative embodiment group) lacking part of components, each embodiment group can remarkably reduce the falling asleep rate and shorten the sleep duration. The components of the examples play very important roles in exerting the effects, and the components are indispensable and synergistic.
The foregoing disclosure is merely illustrative of specific embodiments of the invention, but the embodiments are not limited thereto and variations within the scope of the invention will be apparent to those skilled in the art.
Claims (4)
1. The aromatic refreshment and anti-fatigue traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 3 parts of storax, 3 parts of grassleaf sweelflag rhizome, 2 parts of dalbergia wood and 2 parts of nardostachys root; the preparation method of the aromatic refreshment and anti-fatigue traditional Chinese medicine composition comprises the following steps: weighing storax, grassleaf sweelflag rhizome, rosewood heart wood and nardostachys root in parts by weight, mixing, and extracting volatile oil to obtain the Chinese medicinal composition; the extraction is carried out by adopting supercritical CO 2 Extracting; the supercritical CO 2 The specific process parameters of the extraction are set as follows: the extraction temperature is 55 ℃, the extraction pressure is 30MPa, the extraction time is 120min, and the dosage of entrainer is 10 percent.
2. An application of the traditional Chinese medicine composition of claim 1 in preparing a medicament for refreshing.
3. An aromatic refreshment and anti-fatigue traditional Chinese medicine preparation is characterized by comprising the traditional Chinese medicine composition of claim 1 and pharmaceutically acceptable auxiliary materials or carriers.
4. The aromatic, refreshment and anti-fatigue traditional Chinese medicine preparation according to claim 3, wherein the traditional Chinese medicine preparation is an aerosol, a nasal spray or a nasal suppository.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547868A (en) * | 2015-01-22 | 2015-04-29 | 永春县达埔联发香业有限公司 | Medicine or health product composition for inducing resuscitation for resuscitation as well as preparation method and application of medicine or health product composition |
| WO2018086501A1 (en) * | 2016-11-10 | 2018-05-17 | 罗时富 | Novel ironing moxibustion apparatus combining moxibustion and ironing methods and manufacturing method therefor |
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- 2022-05-06 CN CN202210497848.4A patent/CN114984121B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104547868A (en) * | 2015-01-22 | 2015-04-29 | 永春县达埔联发香业有限公司 | Medicine or health product composition for inducing resuscitation for resuscitation as well as preparation method and application of medicine or health product composition |
| WO2018086501A1 (en) * | 2016-11-10 | 2018-05-17 | 罗时富 | Novel ironing moxibustion apparatus combining moxibustion and ironing methods and manufacturing method therefor |
Non-Patent Citations (2)
| Title |
|---|
| EFFECT OF TAO-HONG-SI-WU-TANG, A TRADITIONAL CHINESE HERBAL MEDICINE FORMULA, ON PHYSICAL FATIGUE IN MICE;Li SS et.al;《Afr J Tradit Complement Altern Med》;第60-5页 * |
| 芳香疗法治疗失眠研究进展;左珂等;《实用中医药杂志》;第1246-1248页 * |
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