CN104225201A - Medicinal composition for treating cough - Google Patents
Medicinal composition for treating cough Download PDFInfo
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- CN104225201A CN104225201A CN201410539363.2A CN201410539363A CN104225201A CN 104225201 A CN104225201 A CN 104225201A CN 201410539363 A CN201410539363 A CN 201410539363A CN 104225201 A CN104225201 A CN 104225201A
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Abstract
The invention belongs to the technical field of medicine and particularly relates to a medicinal composition for treating cough, a preparation method thereof and an application thereof to preparing drugs for treating cough. The medicinal composition comprises the following components of pinellia tuber, tendril-leaved fritillary bulb, greenish lily, almond, mandarin orange, roots of straight ladybell, Chinese angelica, rehmannia roots, dwarf lilyturf tuber, dried tangerine or orange peel, Indian buead, and common mouse ears. The medicinal composition has obvious effects of treating cough and is small in toxic and side effects and applicable to clinical popularization and application.
Description
Technical field
The invention belongs to medical art, relate to a kind of pharmaceutical composition for the treatment of cough, more specifically relate to a kind of pharmaceutical composition for the treatment of cough and preparation method thereof and the purposes in treatment cough medicine.
Background technology
Cough is that internal medicine is gone to a doctor one of modal clinical symptoms of patient, and cough more can not cause a lot of negative effect for a long time, directly affects the quality of life of patient.According to the course of disease, cough is divided into acute, subacute, chronic cough three kinds.Because sickness rate that is subacute and chronic cough is high and the course of disease is longer, patient's Reusability antibiotic or antitussive medicine treatment, poor effect, causes have a strong impact on to patient's physiology, psychology.
Defence as human normal is radiated, and the pressure produced in cough process, speed, energy ensure that body discharges the withered liquid of too much air flue and foreign body, also plays important effect in the process of cardio-pulmonary resuscitation simultaneously.But chronic cough makes coughing centre be in fever state lastingly, body is produced and pays no attention to factor, even can cause the diseases such as tracheitis, pneumonia, pulmonary tuberculosis.Chronic cough's obstinate will produce a series of physiology, psychological problems, even impacts the quality of life of patient.
The traditional Chinese medical science thinks that cough is because of diseases caused by exogenous pathogenic factor six climate exopathogens, internal organs internal injury, affects the sound card having expectorant caused by the lung.Because exopathogen violates lung, or internal organs internal injury, involves caused by the lung.Point out in " Plain Questions pathogenesis gas should save one's life collection " that " cough meaning sound without expectorant, lung qi is hindered and also unclear; It is noiseless and have expectorant for coughing, spleen wet dynamic and be expectorant also.Cough meaning has expectorant and sound, and lid moves in lung qi due to wound and wets in spleen, cough and for coughing also ".
The method for the treatment of cough has a lot, but Western medicine has toxic and side effects mostly, and Chinese patent medicine has little, the eutherapeutic feature of toxic and side effects, therefore is subject to the favor of extensive patients, but clinical practice proves, if Chinese medicine select improper, also can delay treatment.Larger impact is brought on the healthy of people, therefore, deep TCM Syndrome Theories research is carried out to it and seems very necessary.Simultaneously along with the development of society, environment change, pollution grows worse, living standards of the people are improved, and operating pressure increases, the refractory that increasing cough becomes.Modern Chinese medicine is to the discussion of intractable cough still existing defects.Also need to inquire into further from aspects such as pathogenesis, Therapeutic Method, prevention methods, just can have good treatment way to this common sympton of cough and disease.
Summary of the invention
The invention provides a kind of pharmaceutical composition for the treatment of cough, this pharmaceutical composition good effect, toxic and side effects is little, and described pharmaceutical composition is obtained by following raw material: Rhizoma Pinelliae Preparatum, Bulbus Fritillariae Cirrhosae, Bulbus Lilii, Semen Armeniacae Amarum, mandarin orange, Radix Adenophorae (Radix Glehniae), Radix Angelicae Sinensis, Radix Rehmanniae, Radix Ophiopogonis, Pericarpium Citri Reticulatae, Poria, common mouse ear.
There is after pharmaceutical composition of the present invention significant cough-relieving and effect of reducing phlegm.The parts by weight of the present invention to above-mentioned all taste Chinese medicine carry out preferably, preferred condition be after drug matching uses medicine to the enhancing for the treatment of of cough effect.Preferably, pharmaceutical composition of the present invention is obtained by the raw material of following weight portion: Rhizoma Pinelliae Preparatum 6-15g, Bulbus Fritillariae Cirrhosae 3-12g, Bulbus Lilii 15-25g, Semen Armeniacae Amarum 3-9g, mandarin orange 23-27g, Radix Adenophorae (Radix Glehniae) 18-30g, Radix Angelicae Sinensis 13-22g, Radix Rehmanniae 7.5-10.5g, Radix Ophiopogonis 12-23g, Pericarpium Citri Reticulatae 22-39g, Poria 17-26g, common mouse ear 8-12g.As most preferred embodiment of the present invention, pharmaceutical composition of the present invention primarily of following weight portion raw material obtain: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Present invention also offers a kind of preparation method of pharmaceutical composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to the 6-8 times of soak by water twice of fine powder gross weight, time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.04-1.10 (80 DEG C of surveys), let cool to 40 DEG C, adding ethanol makes concentration reach 55-75%, leave standstill 48 hours, reflux, extract, three times, return time is 3.5 ~ 4.5h, filter, filtrate recycling ethanol, cold filtration, wash with water, namely Chinese medical concrete is obtained after drying, those skilled in the art technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.
In order to express pharmaceutical composition of the present invention better, pharmaceutical composition of the present invention can be prepared into dosage form conventional clinically.Such as, powderous preparations, powder, drop pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule etc.Preferably, pharmaceutical composition of the present invention conveniently preparation technology can be prepared into tablet, capsule, granule, drop pill, oral liquid.
The present invention also asks to protect the purposes of aforementioned pharmaceutical compositions in preparation treatment cough medicine.Pharmaceutical composition of the present invention, when treating cough, demonstrates significant cough-relieving and activity of reducing phlegm.Test examples 10 of the present invention shows, pharmaceutical composition of the present invention each dosage group basic, normal, high all significantly or pole extend incubation period of mouse cough significantly, decrease the cough number of times (P<0.05 in 3min, P<0.01), extend incubation period and reduce cough number of times and there is pronounced amount effect relationship, wherein there were significant differences (P<0.01) for high dose.Under same experiment condition, positive control drug also extends the incubation period (P<0.01) of mouse cough, decrease cough number of times (P<0.05), but it improves effect not as good as pharmaceutical composition of the present invention.Test examples 11 of the present invention shows, pharmaceutical composition of the present invention each dosage group basic, normal, high all can significantly or pole significantly improve mice trachea phenols contents (P < 0.05, P < 0.01), show that pharmaceutical composition of the present invention has significant phlegm-dispelling functions, and there is significant dose-effect relationship in its expectorant effect.Under same experiment condition, positive control drug also pole significantly improves mice trachea phenols contents (P < 0.01).
The present invention chooses the clinical of hospital and patient medical history carries out clinical trial, and treat cough patients 189 example altogether, total effective rate reaches 98.94%.Wherein criterion of therapeutical effect comprises following four aspects: fully recover for Clinical symptom and sign disappears, and recovers normal; Effective is that the basic or major part of Clinical symptom and sign disappears; Effectively for clinical symptoms is clearly better; Invalid is that Clinical symptom and sign is without improvement.Instructions of taking: take tablet prepared by pharmaceutical composition of the present invention every day, each 1, every day 2 times, every sheet folding crude drug is about 0.10g, serve on 3 days.To 189 routine patients, adopt pharmaceutical composition of the present invention to carry out and followed the tracks for the treatment of.Wherein, cure 177 examples, effective 7 examples, effective 3 examples, invalid 2 examples, cure rate reaches 93.65%, and total effective rate is 98.94%, so pharmaceutical composition of the present invention is the active drug for the treatment of cough, has good clinical meaning, has significant economic and social benefit.
In addition, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and toxic and side effects significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, significantly or pole extends cough latent period significantly, the cough number of times decreased in 3min, expectorant effect is remarkable, and drug medication of the present invention is convenient, improve compliance and the quality of life of patient, there is significant clinical generalization value.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
Prescription: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.06-1.08 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 65%, leave standstill 48 hours, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare tablet in this preparation method.
Embodiment 2
Prescription: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.06-1.08 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 65%, leave standstill 48 hours, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare capsule in this preparation method.
Embodiment 3
Prescription: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.04-1.06 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 55%, leave standstill 48 hours, reflux, extract, three times, return time is 4.5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare granule in this preparation method.
Embodiment 4
Prescription: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.08-1.10 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 75%, leave standstill 48 hours, reflux, extract, three times, return time is 4.5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare drop pill in this preparation method.
Embodiment 5
Prescription: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.06-1.08 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 70%, leave standstill 48 hours, reflux, extract, three times, return time is 4.5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare oral liquid in this preparation method.
Embodiment 6
Prescription: Rhizoma Pinelliae Preparatum 6g, Bulbus Fritillariae Cirrhosae 3g, Bulbus Lilii 15g, Semen Armeniacae Amarum 3g, mandarin orange 23g, Radix Adenophorae (Radix Glehniae) 18g, Radix Angelicae Sinensis 13g, Radix Rehmanniae 7.5g, Radix Ophiopogonis 12g, Pericarpium Citri Reticulatae 22g, Poria 17g, common mouse ear 8g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 6 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.04-1.06 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 55%, leave standstill 48 hours, reflux, extract, three times, return time is 3.5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare granule in this preparation method.
Embodiment 7
Prescription: Rhizoma Pinelliae Preparatum 15g, Bulbus Fritillariae Cirrhosae 12g, Bulbus Lilii 25g, Semen Armeniacae Amarum 9g, mandarin orange 27g, Radix Adenophorae (Radix Glehniae) 30g, Radix Angelicae Sinensis 22g, Radix Rehmanniae 10.5g, Radix Ophiopogonis 23g, Pericarpium Citri Reticulatae 39g, Poria 26g, common mouse ear 12g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 8 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.08-1.10 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 60%, leave standstill 48 hours, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare tablet in this preparation method.
Embodiment 8
Prescription: Rhizoma Pinelliae Preparatum 15g, Bulbus Fritillariae Cirrhosae 3g, Bulbus Lilii 25g, Semen Armeniacae Amarum 3g, mandarin orange 27g, Radix Adenophorae (Radix Glehniae) 18g, Radix Angelicae Sinensis 22g, Radix Rehmanniae 7.5g, Radix Ophiopogonis 23g, Pericarpium Citri Reticulatae 22g, Poria 17g, common mouse ear 12g.
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.06-1.08 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 70%, leave standstill 48 hours, reflux, extract, three times, return time is 4.5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare capsule in this preparation method.
Embodiment 9
Prescription: Rhizoma Pinelliae Preparatum 6g, Bulbus Fritillariae Cirrhosae 12g, Bulbus Lilii 15g, Semen Armeniacae Amarum 9g, mandarin orange 23g, Radix Adenophorae (Radix Glehniae) 30g, Radix Angelicae Sinensis 13g, Radix Rehmanniae 10.5g, Radix Ophiopogonis 12g, Pericarpium Citri Reticulatae 39g, Poria 26g, common mouse ear 8g
Preparation technology:
Get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to 7 times of soak by water twice of fine powder gross weight, the time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.08-1.10 (80 DEG C of surveys), let cool to 40 DEG C, add ethanol and make concentration reach 65%, leave standstill 48 hours, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art technically prepare tablet in this preparation method.
The antitussive action test of embodiment 10 pharmaceutical composition of the present invention
Get the healthy kunming mice of CL level, body weight 18-20g, 50, male and female half and half, 5 groups are divided at random: blank group, positive controls (dextromethorphan hydrobromide soft capsule by body weight, dosage is 5.85mg/kg) and pharmaceutical composition of the present invention (obtaining by pharmaceutical composition prescription described in embodiment 1 and preparation technology) basic, normal, high dosage group (dosage is 10mg/kg, 30mg/kg, 60mg/kg respectively, all by crude drug gauge), often organize 10.0.5ml/10g gastric infusion.1h after administration, is placed in mice in inverted 500mL beaker, the cotton balls containing 0.3mL ammonia is put into beaker simultaneously, observes immediately and records the cough number of times in the cough latent period of mice and 3min, the results are shown in Table 1.
Table 1 on the cough-relieving of mice affect (
n=10)
Note: compare with normal group, * P < 0.05, * * P < 0.01.
Result shows, pharmaceutical composition of the present invention each dosage group basic, normal, high all significantly or pole extend incubation period of mouse cough significantly, decrease the cough number of times (P<0.05 in 3min, P<0.01), extend incubation period and reduce cough number of times and there is pronounced amount effect relationship, wherein there were significant differences (P<0.01) for high dose.Under same experiment condition, positive control drug also extends the incubation period (P<0.01) of mouse cough, decrease cough number of times (P<0.05), but it improves effect not as good as pharmaceutical composition of the present invention.
The phlegm-dispelling functions test of embodiment 11 pharmaceutical composition of the present invention
Get healthy ICR mice 50, ♀ ♂ half and half, divide 5 groups, 10/group, i.e. model group, positive controls (ambroxol hydrochloride 30mg/kg), pharmaceutical composition of the present invention (obtaining by pharmaceutical composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group (dosage is 10mg/kg, 30mg/kg, 60mg/kg respectively, all by crude drug gauge).Every ig administration 1 time/d, administration 5d, model group ig equal-volume distillation number.30min after last medicine, the phenol red normal saline solution 20mL/kg of ip in mice 5%, put to death animal after 30min, expose trachea, peel off trachea surrounding tissue, cut one section of trachea down to bronchial tree place from thyroid cartilage, jolting is also placed and is spent the night, and obtain transparent supernatant, 546nm place measures the absorbance (μ g/mL) of trachea eluate, (phenol red excretion is more, and the phlegm-dispelling functions of prompting medicine is stronger).The results are shown in Table 2.
Table 2 pharmaceutical composition of the present invention on airway of mice phenols contents impact (
n=10)
Note: compare with model group, * P < 0.05, * * P < 0.01.
Result shows, compare with model group, basic, normal, high three the dosage groups of pharmaceutical composition of the present invention all can significantly or pole significantly improve mice trachea phenols contents (P < 0.05, P < 0.01), show that pharmaceutical composition of the present invention has significant phlegm-dispelling functions, and there is significant dose-effect relationship in its expectorant effect.Under same experiment condition, positive control drug also pole significantly improves mice trachea phenols contents (P < 0.01).
Claims (5)
1. treat the pharmaceutical composition of cough for one kind, it is characterized in that, it is obtained by the raw material of following weight portion: Rhizoma Pinelliae Preparatum 6-15g, Bulbus Fritillariae Cirrhosae 3-12g, Bulbus Lilii 15-25g, Semen Armeniacae Amarum 3-9g, mandarin orange 23-27g, Radix Adenophorae (Radix Glehniae) 18-30g, Radix Angelicae Sinensis 13-22g, Radix Rehmanniae 7.5-10.5g, Radix Ophiopogonis 12-23g, Pericarpium Citri Reticulatae 22-39g, Poria 17-26g, common mouse ear 8-12g.
2. pharmaceutical composition as claimed in claim 1, is characterized in that it is obtained by the raw material of following weight portion: Rhizoma Pinelliae Preparatum 10.5g, Bulbus Fritillariae Cirrhosae 8g, Bulbus Lilii 20g, Semen Armeniacae Amarum 6g, mandarin orange 25g, Radix Adenophorae (Radix Glehniae) 24g, Radix Angelicae Sinensis 18g, Radix Rehmanniae 9g, Radix Ophiopogonis 17g, Pericarpium Citri Reticulatae 30g, Poria 21g, common mouse ear 10g.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared by following steps and obtains: get the above-mentioned Chinese crude drug of recipe quantity and be broken into 100 object fine powders, according to the 6-8 times of soak by water twice of fine powder gross weight, time is respectively 2 hours and 3 hours, merge twice decocting liquid, filter, being concentrated into relative density is 1.04-1.10 (80 DEG C of surveys), let cool to 40 DEG C, adding ethanol makes concentration reach 55-75%, leave standstill 48 hours, reflux, extract, three times, return time is 3.5 ~ 4.5h, filter, filtrate recycling ethanol, cold filtration, wash with water, namely Chinese medical concrete is obtained after drying, those skilled in the art technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.
4. pharmaceutical composition as claimed in claim 3, it is characterized in that, described dosage form is tablet, capsule, granule, drop pill, oral liquid.
5. the purposes of the pharmaceutical composition as described in as arbitrary in claim 1-4 in preparation treatment cough medicine.
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| CN201410539363.2A CN104225201A (en) | 2014-10-13 | 2014-10-13 | Medicinal composition for treating cough |
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| CN201410539363.2A CN104225201A (en) | 2014-10-13 | 2014-10-13 | Medicinal composition for treating cough |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079571A (en) * | 2015-09-19 | 2015-11-25 | 南京正亮医药科技有限公司 | Medicinal preparation for treating senility lung infection |
| CN107854665A (en) * | 2017-12-26 | 2018-03-30 | 广西壮要方医院有限公司 | A kind of pharmaceutical composition for treating cough |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972440A (en) * | 2010-10-08 | 2011-02-16 | 张继成 | Chinese medicinal composition for relieving cough and asthma |
| CN102846925A (en) * | 2012-09-13 | 2013-01-02 | 安徽丰原药业股份有限公司 | Traditional Chinese medicine composition used for treating cough |
| CN103638513A (en) * | 2013-12-26 | 2014-03-19 | 陈屹迪 | Pectoral syrup for tonifying spleen and nourishing stomach |
-
2014
- 2014-10-13 CN CN201410539363.2A patent/CN104225201A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972440A (en) * | 2010-10-08 | 2011-02-16 | 张继成 | Chinese medicinal composition for relieving cough and asthma |
| CN102846925A (en) * | 2012-09-13 | 2013-01-02 | 安徽丰原药业股份有限公司 | Traditional Chinese medicine composition used for treating cough |
| CN103638513A (en) * | 2013-12-26 | 2014-03-19 | 陈屹迪 | Pectoral syrup for tonifying spleen and nourishing stomach |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079571A (en) * | 2015-09-19 | 2015-11-25 | 南京正亮医药科技有限公司 | Medicinal preparation for treating senility lung infection |
| CN107854665A (en) * | 2017-12-26 | 2018-03-30 | 广西壮要方医院有限公司 | A kind of pharmaceutical composition for treating cough |
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Application publication date: 20141224 |