CN105079571A - Medicinal preparation for treating senility lung infection - Google Patents

Abstract

The invention belongs to the field of Chinese herbal preparations, and particularly provides a medicinal preparation for treating senility lung infection. The medicinal preparation is prepared from the following raw materials in parts by weight: 30 parts of ciliatenerve knotweed root, 15 parts of tubeflower viburnum herb, 18 parts of eucheuma, 25 parts of herb or root of common rockvine, 18 parts of fritillaria thun-bergli, 18 parts of trichosanthes peel, 15 parts of lotus leaves, 20 parts of lily, 25 parts of rhizoma anemarrhenae, 20 parts of lophatherum gracile, 25 parts of adenophora tetraphylla, 20 parts of honeysuckle flowers, 15 parts of pinellia ternata, 15 parts of dried tangerine or orange peel, 15 parts of apricot kernels, 25 parts of rehmannia, 15 parts of bark of mangnolia officinalis, and 5 parts of licorice root. The medicinal preparation can treat senility lung infection.

Description

A kind of pharmaceutical preparation being used for the treatment of person in middle and old age's pulmonary infection

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind ofly be used for the treatment of pharmaceutical preparation of person in middle and old age's pulmonary infection and its preparation method and application.

Background technology

Pneumonia is the most common with bacterial infection, is secondly virus and mycoplasma, chlamydia infection.Have investigation display, over-65s senile pneumonia sickness rate is youthful 5.4 times, and overall mortality rate, up to more than 30%, is youthful 6.2 times.Pneumonia has become the 4th the lethal cause of disease of over-65s old people, is the first cause of the death of more than 80 years old aged.For this reason, the needs that the medicine developing the more person in middle and old age for the treatment of safely and effectively pulmonary infections meets clinical treatment are bursting to.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of person in middle and old age's pulmonary infection disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of person in middle and old age's pulmonary infection, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Polygoni Ciliinerve 30 parts, Folium Viburni Cylindrici 15 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 18 parts, Herba Seu Radix Tetrastigmatis Obtecti 25 parts, Bulbus Fritillariae Uninbracteatae 18 parts, Pericarpium Trichosanthis 18 parts, 15 parts, Folium Nelumbinis, Bulbus Lilii 20 parts, the Rhizoma Anemarrhenae 25 parts, Herba Lophatheri 20 parts, Radix Adenophorae 25 parts, Flos Lonicerae 20 parts, the Rhizoma Pinelliae 15 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Semen Armeniacae Amarum, Radix Rehmanniae 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.

The described pharmaceutical preparation being used for the treatment of person in middle and old age's pulmonary infection, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of person in middle and old age's pulmonary infection, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of pharmaceutical preparation in preparation treatment person in middle and old age lung infection medicine being used for the treatment of person in middle and old age's pulmonary infection.

Radix Polygoni Ciliinerve is Polygonaceae Pteroxygonum plant Pteroxygonum giraldii PteroxygonumgiraldiiDamm.etDiels, is used as medicine with tuber.Autumn excavates, removing stem and leaf and fibrous root, and clean section is dried: heat clearing away, removing toxic substances, hemostasis, pain relieving.For enteritis, dysentery, lumbago and skelalgia, has blood in stool, metrorrhagia; Burn and scald is controlled in external, furuncle, lyssodexis.

Folium Viburni Cylindrici be Radix Ophiopogonis Piao's vegetation water redwood leaf or root, flower.Clearing away heat and cooling blood, removing dampness dredging collateral.Control cough caused by dryness, dysentery, rheumatalgia, traumatic injury, skin infection scabies.

Eucheuma muricatum (Gmel.) Web.Van Bos. is the frond of Hong Ling dish section plant Eucheuma muricatum (Gmel.) Web.Van Bos. or Margarita Eucheuma muricatum (Gmel.) Web.Van Bos..Expectorant.Can be reduced phlegm knot, mass in the abdomen, hemorrhoid poison.

Herba Seu Radix Tetrastigmatis Obtecti is that rattan Tetrastigmaobtectum (Wall.exLaws.) Planch. is climbed on Vitaceae Tetrastigma plant precipice, is used as medicine with Herb.The whole year can adopt, and dries for subsequent use or using fresh herb.Dispel the wind, dehumidifying, promoting the circulation of blood, detoxicating functions, can control headache, general pain, rheumatic arthralgia, multiple abscess, sore.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science is thought, person in middle and old age's pulmonary infection mostly is stagnation of QI due to depression of the liver, weakness of the spleen and stomach is done, Radix Polygoni Ciliinerve of the present invention, Folium Viburni Cylindrici, Eucheuma muricatum (Gmel.) Web.Van Bos., Herba Seu Radix Tetrastigmatis Obtecti, Bulbus Fritillariae Uninbracteatae, Pericarpium Trichosanthis, Folium Nelumbinis nourishing lung yin are monarch drug, and Bulbus Lilii, the Rhizoma Anemarrhenae, Herba Lophatheri, Radix Adenophorae, Flos Lonicerae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Semen Armeniacae Amarum, Radix Rehmanniae, Cortex Magnoliae Officinalis warming yang for resolving fluid retention are ministerial drug, and Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, nourish lung yin, air making-up and spleen enlivening, warming yang for resolving fluid retention, treatment person in middle and old age pulmonary infection successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Radix Polygoni Ciliinerve 30g, Folium Viburni Cylindrici 15g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Herba Seu Radix Tetrastigmatis Obtecti 25g, Bulbus Fritillariae Uninbracteatae 18g, Pericarpium Trichosanthis 18g, Folium Nelumbinis 15g, Bulbus Lilii 20g, Rhizoma Anemarrhenae 25g, Herba Lophatheri 20g, Radix Adenophorae 25g, Flos Lonicerae 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Semen Armeniacae Amarum 15g, Radix Rehmanniae 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Radix Polygoni Ciliinerve 30g, Folium Viburni Cylindrici 15g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Herba Seu Radix Tetrastigmatis Obtecti 25g, Bulbus Fritillariae Uninbracteatae 18g, Pericarpium Trichosanthis 18g, Folium Nelumbinis 15g, Bulbus Lilii 20g, Rhizoma Anemarrhenae 25g, Herba Lophatheri 20g, Radix Adenophorae 25g, Flos Lonicerae 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Semen Armeniacae Amarum 15g, Radix Rehmanniae 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get Radix Polygoni Ciliinerve 30g, Folium Viburni Cylindrici 15g, Eucheuma muricatum (Gmel.) Web.Van Bos. 18g, Herba Seu Radix Tetrastigmatis Obtecti 25g, Bulbus Fritillariae Uninbracteatae 18g, Pericarpium Trichosanthis 18g, Folium Nelumbinis 15g, Bulbus Lilii 20g, Rhizoma Anemarrhenae 25g, Herba Lophatheri 20g, Radix Adenophorae 25g, Flos Lonicerae 20g, Rhizoma Pinelliae 15g, Pericarpium Citri Reticulatae 15g, Semen Armeniacae Amarum 15g, Radix Rehmanniae 25g, Cortex Magnoliae Officinalis 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment person in middle and old age pulmonary infection of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation person in middle and old age pulmonary infection case 50 example, 62 ~ 75 years old age.The shortest person of the course of disease 4 months, most elder reaches 1 year.

4.2 diagnostic criterias: (1), how without classical symptoms such as generating heat, cough up phlegm, has symptom only to account for 35%.(2) starting disease to be accelerated and dyspnea person accounts for 56% for breathing, or sicken for consciousness, drowsiness, dehydration, loss of appetite etc., asymptomatic person accounts for 10%.(3) sign: rapid pulse can be occurred, breathe fast, chest auscultation audible and moist rale, or with diminished breath sound and bronchovesicular breathing sound.(4) blood test: blood routine examination total white blood cells can increase or not high, but the inflammation performance such as Visible Core more than half moves to left, c reactive protein positive, erythrocyte sedimentation rate is fast.(5) arterial blood gas analysis: can occur that art pO2 declines, but when merging chronic obstructive pulmonary disease, because the bad partial pressure of carbon dioxide of alveolar ventilation raises.(6) C-XF is that bronchopneumonia form person is more common than lobar pneumonia.(7) easily there is water and rock-soil coupling in Pneumonia in Older Patients, acidosis.Because concurrent chronic disease patient is many, easily MOFE occurs, mortality rate is high.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: recovery from illness: symptom all disappears; Effective: symptom obviously alleviates; Invalid: without significant change or deterioration before and after treatment.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effectively	Invalid	Total effective rate (%)
						Treatment group	25	7	14	4	84
Blank group	25	0	1	24	4

Visible, the medicine that the present invention obtains can safe and effective treatment person in middle and old age pulmonary infection, and has no side effect.

Claims (4)

1. one kind is used for the treatment of the pharmaceutical preparation of person in middle and old age's pulmonary infection, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Polygoni Ciliinerve 30 parts, Folium Viburni Cylindrici 15 parts, Eucheuma muricatum (Gmel.) Web.Van Bos. 18 parts, Herba Seu Radix Tetrastigmatis Obtecti 25 parts, Bulbus Fritillariae Uninbracteatae 18 parts, Pericarpium Trichosanthis 18 parts, 15 parts, Folium Nelumbinis, Bulbus Lilii 20 parts, the Rhizoma Anemarrhenae 25 parts, Herba Lophatheri 20 parts, Radix Adenophorae 25 parts, Flos Lonicerae 20 parts, the Rhizoma Pinelliae 15 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Semen Armeniacae Amarum, Radix Rehmanniae 25 parts, Cortex Magnoliae Officinalis 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of the pharmaceutical preparation of person in middle and old age's pulmonary infection as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the pharmaceutical preparation of person in middle and old age's pulmonary infection as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. the application of the pharmaceutical preparation being used for the treatment of person in middle and old age's pulmonary infection according to claim 1 in the treatment in Aged Patients With Lung infection medicine.