CN105055786A - Medicinal preparation for treating cough - Google Patents
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Abstract
The invention belongs to the field of Chinese medicinal preparations, and specifically provides a medicinal preparation for treating cough. The medicinal preparation is prepared from the following raw materials: 25 parts of longstalk condorvine herb, 20 parts of common achyranthes herb, 18 parts of Chinese brake herb, 18 parts of lobedfruit tacca tuber, 10 parts of white mulberry boot-bark, 15 parts of purple perilla, 20 parts of red paeony root, 20 parts of Chinese yam, 25 parts of platycodon root, 25 parts of Chinese thorowax root, 20 parts of astragalus, 15 parts of loguat leaf, 18 parts of weeping forsythia, 15 parts of apricot kernel, 20 parts of pinellia tuber, 15 parts of fructus aurantii and 5 parts of liquoric root. The medicinal preparation can be used for treating cough.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of cough and its preparation method and application.
Background technology
Cough is the protectiveness respiratory reflex action that human body removes secretions in respiratory tract or foreign body.Although there is the one side that it is favourable, violent chronic cough can cause respiratory tract hemorrhage.Correct differentiation is generally coughed and cough variant asthma, prevents mistaken diagnosis.Cough is because of diseases caused by exogenous pathogenic factor six climate exopathogens, internal organs internal injury, affects the sound disease having expectorant caused by the lung.See " Plain Questions the five internal organs generate a section "." Plain Questions pathogenesis gas should save one's life collection ": " cough meaning sound without expectorant, lung qi is hindered and also unclear; It is noiseless and have expectorant for coughing, spleen wet dynamic and be expectorant also.Cough meaning has expectorant and sound, and lid moves in lung qi due to wound and wets in spleen, cough and for coughing also ".For this reason, be bursting to and develop the needs that more medicines for the treatment of cough safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cough disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of cough, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Marsdeniae Longipedis 25 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 20 parts, Herba Pteridis Multifidae 18 parts, Rhizoma Schizocapsae Plantagineae 18 parts, Cortex Mori 10 parts, Folium Perillae 15 parts, Radix Paeoniae Rubra 20 parts, Rhizoma Dioscoreae 20 parts, Radix Platycodonis 25 parts, Radix Bupleuri 25 parts, the Radix Astragali 20 parts, Folium Eriobotryae 15 parts, Fructus Forsythiae 18 parts, 15 parts, Semen Armeniacae Amarum, the Rhizoma Pinelliae 20 parts, Fructus Aurantii 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of cough, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of cough, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment cough medicine being used for the treatment of cough.
Radix Marsdeniae Longipedis is the Herb of asclepiadaceae plant Radix Marsdeniae Longipedis.Promoting blood circulation and hemostasis, relieving cough and asthma.For traumatic injury, rheumatalgia, internal hemorrhage, bronchitis, asthma; Fracture is controlled in external, traumatic hemorrhage.Relaxing muscles and tendons and activating QI and blood in the collateral, invigorating deficiency and relieving dyspnea.
Radix achyranthis asperae (Herba Achyranthis Asperae), Latin is called: AchyranthesasperaL. is the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.Heat clearing away, induces sweat, and diuretic is invigorated blood circulation.Cure mainly: cold, fever, dysentery, malaria, laryngalgia, beriberi, gonorrhea.Edema, traumatic injury.
Herba Pteridis Multifidae is a kind of pteridophyta, belongs to Pteridaceae, Pteris.Formal name used at school Pterismultifdapoir.Happiness growth is at concealment, moistening, warm place.Also drought-enduring, in southern winter, the plant arid in warp-February grown in crack of stone, still unlikely completely withered.The main product Yangtze river basin and on the south each province, district, the north Shaanxi, Hebei, Shandong etc. economize also have distribution.With all herbal medicine, tonifying blood and regulating menstruation, yin nourishing.For menoxenia, deficiency of YIN hectic fever, has a dizzy spell, women's asthenia.
The tuber of Rhizoma Schizocapsae Plantagineae Wei Rhizoma amorphophalli potato section plant dehiscent fruit potato.Heat-clearing and toxic substances removing; Eliminating phlegm and stopping cough; Regulate the flow of vital energy and stop production capacity; Dissipating blood stasis stops blooding.Main cold, fever; Phlegm-heat cough; Pertussis; Abdominal distention; Dysentery is suffered from abdominal pain; Dyspepsia; Infantile malnutrition; Hepatitis; Laryngopharynx swelling and pain; Toothache; Mumps; Scrofula; Skin ulcer swells; Scald, burn; Herpes zoster; Traumatic injury; Traumatic hemorrhage.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks lung associating with skin and hair, exopathogen attacks table, impairment of dispersing and descending function of the lung, then has cough, Radix Marsdeniae Longipedis of the present invention, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba Pteridis Multifidae, Rhizoma Schizocapsae Plantagineae, Cortex Mori, Folium Perillae, Radix Paeoniae Rubra heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing are monarch drug, Rhizoma Dioscoreae, Radix Platycodonis, Radix Bupleuri, the Radix Astragali, Folium Eriobotryae, Fructus Forsythiae, Semen Armeniacae Amarum, the Rhizoma Pinelliae, Fructus Aurantii removing heat from the lung and relieving sorethroat are ministerial drug, and Radix Glycyrrhizae is adjuvant, full side compatibility mutually, to removing heat from the lung and relieving sorethroat, preventing phlegm from forming and stopping coughing, lung moistening and asthma relieving, treatment cough successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Radix Marsdeniae Longipedis 25g, Radix achyranthis asperae (Herba Achyranthis Asperae) 20g, Herba Pteridis Multifidae 18g, Rhizoma Schizocapsae Plantagineae 18g, Cortex Mori 10g, Folium Perillae 15g, Radix Paeoniae Rubra 20g, Rhizoma Dioscoreae 20g, Radix Platycodonis 25g, Radix Bupleuri 25g, Radix Astragali 20g, Folium Eriobotryae 15g, Fructus Forsythiae 18g, Semen Armeniacae Amarum 15g, Rhizoma Pinelliae 20g, Fructus Aurantii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Radix Marsdeniae Longipedis 25g, Radix achyranthis asperae (Herba Achyranthis Asperae) 20g, Herba Pteridis Multifidae 18g, Rhizoma Schizocapsae Plantagineae 18g, Cortex Mori 10g, Folium Perillae 15g, Radix Paeoniae Rubra 20g, Rhizoma Dioscoreae 20g, Radix Platycodonis 25g, Radix Bupleuri 25g, Radix Astragali 20g, Folium Eriobotryae 15g, Fructus Forsythiae 18g, Semen Armeniacae Amarum 15g, Rhizoma Pinelliae 20g, Fructus Aurantii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Radix Marsdeniae Longipedis 25g, Radix achyranthis asperae (Herba Achyranthis Asperae) 20g, Herba Pteridis Multifidae 18g, Rhizoma Schizocapsae Plantagineae 18g, Cortex Mori 10g, Folium Perillae 15g, Radix Paeoniae Rubra 20g, Rhizoma Dioscoreae 20g, Radix Platycodonis 25g, Radix Bupleuri 25g, Radix Astragali 20g, Folium Eriobotryae 15g, Fructus Forsythiae 18g, Semen Armeniacae Amarum 15g, Rhizoma Pinelliae 20g, Fructus Aurantii 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment cough clinical research of the present invention
4.1 general data: this pharmaceutical preparation is applied to clinical observation cough case 40 example, 19 ~ 48 years old age.The shortest person of the course of disease 1 month, most elder reaches 1 year.
4.2 diagnostic criterias:
4.2.1 cough with dyspnea is sound, or the expectoration of companion's itching throat.
4.2.2 exogenous cough, onset is anxious, can with exterior syndromes such as cold and heat.
4.2.3 endogenous cough, often because of diseases caused by exogenous pathogenic factor recurrent exerbation, the course of disease is longer, can cough and accompany and breathe heavily.
4.2.4 acute stage, have a blood test total white blood cells and neutrophilic granulocyte increased.
4.2.5 two lung auscultation audibles and respiratory murmur increase thick, or companion is dispersed in dry moist rale.
4.2.6 conducting lung X-ray examination takes the photograph sheet inspection, normal or increased bronchovascular shadows.
4.2.7 syndrome-classification: wind-cold affecting lung: cough low voice speaking, thin color of coughing up phlegm is white, aversion to cold, or has heating, lossless.Thin white fur of tongue, floating and tense pulse.Wind-heat invading the lung: cough rough, coughs up phlegm sticky white or yellow, pharyngalgia or to cough hoarseness mute, or has heating, and micro evil wind is trembled with fear, and mouth is yearningly micro-.Red tip of the tongue, white or yellow thin fur, floating and rapid pulse.Pathogenic dryness impairing the lung: the few expectorant of dry cough, cough up phlegm not well, nasopharynx is dry, xerostomia.Red tip of the tongue, the few Tianjin of yellow and thin fur, thready and rapid pulse.Phlegm-heat obstructing in the lung: cough rough, the thick Huang of abundant expectoration, restlessness and fever with thirst.Red tongue, yellow and greasy fur, slippery and rapid pulse.Liver-fire invading the lung: cough and dyspnea with choke battle array is done, and dragging pain between the chest and hypochondrium when coughing, very then spits blood, red tongue, the few Tianjin of yellow and thin fur, wiry and frequent pulse.Phlegm dampness in lungs: heavy cough, abundant expectoration color is white, rises morning as very, gastral cavity painful abdominal mass uncomfortable in chest, anorexia.White and greasy fur, rolling pulse.Lung yin virtual loss: cough expectorant of a specified duration few, cough up tell not well, the sticky or folder blood streak of expectorant, dry mouth and throat, feverish sensation in the palms and soles.Red tongue, few tongue, thready and rapid pulse.Lung qi virtual loss: sick chronic cough low voice is micro-, coughs and accompanies and breathe heavily, and coughing up thin sputum color is white, and lack of appetite, breathes hard uncomfortable in chest, and god is tired weak, spontaneous perspiration fear of cold.Light red tongue is tender, and tongue is white, weak pulse.Various syndrome all belongs to cough above.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: cure: cough and clinical sign disappear; Endogenous cough did not send out author for clinical cure more than two weeks.Take a turn for the better: cough alleviates, amount of expectoration reduces.Invalid: symptom is without obvious change.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 20 | 6 | 11 | 3 | 85 |
| Blank group | 20 | 1 | 1 | 18 | 10 |
Visible, the medicine that the present invention obtains can be coughed in safe and effective treatment, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of cough, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Marsdeniae Longipedis 25 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 20 parts, Herba Pteridis Multifidae 18 parts, Rhizoma Schizocapsae Plantagineae 18 parts, Cortex Mori 10 parts, Folium Perillae 15 parts, Radix Paeoniae Rubra 20 parts, Rhizoma Dioscoreae 20 parts, Radix Platycodonis 25 parts, Radix Bupleuri 25 parts, the Radix Astragali 20 parts, Folium Eriobotryae 15 parts, Fructus Forsythiae 18 parts, 15 parts, Semen Armeniacae Amarum, the Rhizoma Pinelliae 20 parts, Fructus Aurantii 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of cough as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of cough as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment cough medicine of cough according to claim 1.
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| CN201510588910.0A CN105055786A (en) | 2015-09-16 | 2015-09-16 | Medicinal preparation for treating cough |
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| CN201510588910.0A CN105055786A (en) | 2015-09-16 | 2015-09-16 | Medicinal preparation for treating cough |
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| CN105055786A true CN105055786A (en) | 2015-11-18 |
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| CN107041927A (en) * | 2017-02-27 | 2017-08-15 | 曹景玉 | A kind of traditional Chinese medicine nourishment maintenance gives birth to Health-care powder |
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