CN116019860B - Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof - Google Patents
Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides compound essential oil with the effects of inducing resuscitation and refreshing mind, and a preparation method and application thereof. The preparation method comprises the following steps of: borneol, storax essential oil, rose essential oil, jasmine essential oil and benzoin essential oil. The compound essential oil is prepared by utilizing the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicines, adopting borneol as a monarch drug, adopting storax essential oil as a ministerial drug, adopting rose essential oil and jasmine essential oil as assistants and adopting benzoin essential oil as guides, and can be used for relieving symptoms such as dizziness, fatigue and fatigue caused by hypoxia. The preparation method comprises the step of uniformly mixing the preparation raw materials according to the proportion. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, the raw materials are rich, the borneol is easy to permeate the blood brain barrier, and other essential oil components can be promoted to permeate the blood brain barrier to play an anti-hypoxia role. The whole formula is scientific in proportion and strong in drug effect. Experimental study shows that the anti-hypoxia effect is remarkable.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to compound essential oil with effects of inducing resuscitation and refreshing mind, and a preparation method and application thereof.
Background
With the acceleration of life rhythm, the phenomenon of sitting for a long time in offices is more common, and the symptoms of debilitation and lassitude can be caused by long-term keeping of sitting and lying states or overlong use time of electronic products, or partial carbon dioxide retention and water vapor formation and unsmooth air flow caused by long-time wearing of a mask can reduce oxygen content in the body, so that cerebral blood and oxygen supply are insufficient. If the tissue cells of the human body are in an anoxic state, symptoms such as dizziness, fatigue, tiredness and the like are easy to occur, and the ancient doctors and doctors often refer to the disease as brain-orifices disease. Brain diseases are probably caused by brain qi occlusion or internal pathogenic qi obstruction of marrow and qi obstruction; while qi is the general and blood is the mother of qi, qi and blood are generated, so it is indicated for resuscitation and resuscitation, qi-moving and blood-activating. Aromatic for resuscitation and treatment of resuscitation is first indicated for resuscitation. The aromatic volatile oil has the effects of pungent and fragrant nature, dredging the orifices and inducing resuscitation, and quick medicinal effect, has the effects of promoting qi and blood circulation, removing obstruction and relieving obstruction of channels and collaterals, and can treat adverse effects of orifices, unconsciousness and obstruction of qi and blood.
The natural plant essential oil is a colored, odorous, volatile and high-concentration aromatic substance, and mostly has various functions of resisting bacteria, regulating emotion, relieving tension and the like, and the volatile odor molecules can enter the brain through olfactory organs and regulate emotion and body functions. Some volatile oils have anti-anoxia effect, such as Borneolum, benzoin, styrax, petroleum ether, and n-butanol extraction site, and have anti-acute anoxia injury effect.
The compound essential oil with the effects of inducing resuscitation and refreshing mind provided by the invention is safe in source and unique in fragrance, and can meet the requirements of users.
Disclosure of Invention
The invention aims to provide compound essential oil with definite effect and capable of inducing resuscitation and refreshing mind and a preparation method thereof. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, has scientific formula proportion, has obvious effects of inducing resuscitation and refreshing mind, and can effectively improve the problem of cerebral hypoxia.
The first aspect of the invention discloses a compound essential oil for inducing resuscitation and refreshing, which comprises the following preparation raw materials: borneol, storax essential oil, rose essential oil, jasmine essential oil and benzoin essential oil.
In some embodiments, the preparation materials include the following parts by weight: 1-20 parts of borneol, 1-8 parts of threo essential oil, 10-120 parts of rose essential oil, 1-30 parts of jasmine essential oil and 1-30 parts of benzoin essential oil.
In some embodiments, the preparation materials include the following parts by weight: 1-5 parts of borneol, 1-3 parts of threo essential oil, 15-25 parts of rose essential oil, 3-9 parts of jasmine essential oil and 3-9 parts of benzoin essential oil.
In some embodiments, the preparation materials include the following parts by weight: 2.5 parts of borneol, 1 part of threo essential oil, 20 parts of rose essential oil, 5 parts of jasmine essential oil and 5 parts of benzoin essential oil.
The second aspect of the invention provides a preparation method of the compound essential oil, which is characterized in that the preparation raw materials are uniformly mixed.
The third aspect of the invention provides a compound essential oil, which is characterized by being prepared according to the preparation method.
The fourth aspect of the invention provides application of the compound essential oil, which is characterized in that the compound essential oil is used for inducing resuscitation and refreshing.
The fifth aspect of the invention provides the application of the compound essential oil in preparing anti-hypoxia drugs or sanitary products. The method is characterized in that: the anti-hypoxia medicament is a spray formed by compound essential oil, or a civil sanitary product prepared by taking the compound essential oil as an active ingredient and adding conventional auxiliary materials according to a conventional preparation process of traditional Chinese medicines, and comprises a mask, a sachet and the like.
The sixth aspect of the invention provides an anti-hypoxia drug, which is characterized by comprising the compound essential oil. The antihypoxic may also include pharmaceutically acceptable adjuvants.
The seventh aspect of the invention provides a refreshing efficacy evaluation of the compound essential oil on subjective feeling of human body.
Compared with the prior art, the invention has the following technical advantages:
(1) The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, and has the advantages of rich raw materials and scientific formula ratio.
(2) Borneol is used as a monarch drug in the compound essential oil, so that the drug can directly reach focus; storax is a ministerial drug which can assist monarch drugs in inducing resuscitation and refreshing mind and improve symptoms of headache and dizziness; the roses and the jasmine are used for simultaneously restoring liver meridian, and are used as adjuvant drugs for soothing liver and relieving depression, improving qi stagnation, depression and qi and blood obstruction of women caused by liver failure and diarrhea, and promoting blood circulation and qi circulation; benzonum is used for inducing resuscitation and refreshing mind, promoting qi and activating blood circulation, and regulating odor. The formula has the effects of promoting qi to induce resuscitation, promoting qi to promote blood circulation, inducing resuscitation, promoting qi to activate blood, and improving cerebral anoxia.
(3) Experimental study shows that the compound essential oil provided by the invention has remarkable anti-hypoxia activity.
(4) The preparation method is simple, does not need a complex preparation process, and is economical and environment-friendly.
(5) The compound essential oil provided by the invention is safe in source, quick in absorption and remarkable in effect, and can meet the requirements of users.
Drawings
FIG. 1 is a graph of data showing the effect of compound essential oil of example 1 on sodium dithionite-induced survival of PC12 nerve cells;
FIG. 2 is a graph of data showing the effect of storax monosodium glutamate oil on sodium dithionite-induced survival of PC12 nerve cells;
FIG. 3 is a graph of data showing the effect of rose monosultap oil on sodium dithionite-induced survival of PC12 neurons;
FIG. 4 is a graph of data showing the effect of jasmine monosodium glutamate oil on sodium dithionite-induced survival of PC12 nerve cells;
FIG. 5 is a graph showing the evaluation results of subjective feelings of the compound essential oil of example 1 on human bodies;
compared to the control group, (# # P < 0.001);
Compared with the model group, the P is less than 0.1, P is less than 0.01 and P is less than 0.001.
Detailed Description
The invention is further illustrated by means of the following examples, which are not intended to limit the scope of the invention. The experimental methods, in which specific conditions are not noted in the following examples, were selected according to conventional methods and conditions, or according to the commercial specifications.
Borneol is pungent and bitter in taste, slightly cold in nature, and enters heart, spleen and lung meridians, and can induce resuscitation and refresh mind, clear heat and alleviate pain. The modern clinical research shows that the borneol can strengthen the permeability of the blood brain barrier, proves the knowledge of ' ascending medicine and ' assisting active medicine ' of the borneol in the traditional Chinese medicine, has a certain brain protection effect, and obviously prolongs the hypoxia tolerance time of mice and enhances the tolerance of organisms to hypoxia through the toxicity hypoxia experimental model in intraperitoneal injection sodium nitrite simulation.
Su He has pungent flavor, warm nature, and can induce resuscitation, relieve dirt and pain after entering heart and spleen meridians. Studies show that storax can increase the opening times and time of mice after end breakage to different degrees, can prolong the opening and gasping time of mice after injection of saturated magnesium chloride solution, can prolong the survival time of mice under normal pressure hypoxia, and shows that storax has the effect of resisting acute cerebral ischemia hypoxia.
The rose is sweet in taste and slightly bitter in nature, warm in nature, enters liver and spleen meridians, and can promote qi to resolve depression, harmonize blood and alleviate pain. The rose essential oil has strong qi regulating effect, and can promote qi flow to activate blood, soothe liver and relieve depression.
Jasmine is pungent and slightly sweet in flavor, warm in nature, enters spleen, stomach and liver meridians, and can regulate qi, resolve depression, and clear dirt and harmonize middle energizer. Research shows that jasmine has dendrobine and can positively influence the operation of a nervous system. Research results show that the jasmine essential oil can improve the awakening activity of the autonomic nerves and is helpful for improving emotion.
Benzoin is pungent and bitter in flavor and neutral in nature. It can induce resuscitation, refresh mind, activate qi, promote blood circulation and relieve pain after entering heart and spleen meridians. Studies show that benzoin can obviously improve the superoxide dismutase content in brain tissues of mice with acute cerebral ischemia and reduce the malondialdehyde content; benzonum and serum containing the benzoin have protective effect on ischemia and hypoxia PC12 cells.
Example 1
And mixing 2.5 parts by weight of borneol, 1 part by weight of storax essential oil, 20 parts by weight of rose essential oil, 5 parts by weight of jasmine essential oil and 5 parts by weight of benzoin essential oil uniformly to obtain the compound essential oil.
Example 2
Mixing Borneolum 5 weight parts, storax 2 weight parts, flos Rosae Rugosae 40 weight parts, flos Jasmini sambac 10 weight parts, and benzoin 10 weight parts to obtain compound essential oil.
Example 3
And mixing 7.5 parts by weight of borneol, 3 parts by weight of storax essential oil, 60 parts by weight of rose essential oil, 15 parts by weight of jasmine essential oil and 15 parts by weight of benzoin essential oil uniformly to obtain the compound essential oil.
Example 4
Mixing Borneolum 10 weight parts, storax oil 4 weight parts, flos Rosae Rugosae oil 80 weight parts, flos Jasmini sambac oil 20 weight parts, and benzoin essential oil 20 weight parts to obtain compound essential oil.
Example 5
And mixing 12.5 parts by weight of borneol, 5 parts by weight of storax essential oil, 100 parts by weight of rose essential oil, 25 parts by weight of jasmine essential oil and 25 parts by weight of benzoin essential oil uniformly to obtain the compound essential oil.
Example 6
Mixing Borneolum 15 weight parts, storax 6 weight parts, flos Rosae Rugosae 120 weight parts, flos Jasmini sambac 30 weight parts, and benzoin 30 weight parts to obtain compound essential oil.
Example 7
Drug efficacy and safety experiment:
(1) Influence of the Compound essential oil of the invention on the survival rate of the sodium dithionite-induced PC12 cell injury model:
And detecting the anti-hypoxia activity of the essential oil based on the cytotoxicity concentration of the essential oil on PC 12. PC12 cells in the logarithmic growth phase were inoculated into 96-well plates at a cell density of about 2.5X104. Multidot.mL －1 cell suspension and cultured. The cells were incubated at 37℃under 5% CO 2 for 24 hours. After the cells adhere to the wall, the original medium is discarded. Cells were divided into control, model and dosing groups. The control group and the model group are added with 100 mu L of 1640 culture medium for culture, the concentration of compound essential oil in the administration group is 3/20, 4/20, 5/20, 6/20, 7/20, 8/20, 9/20, 10/20 and 11/20 of the original formula, the storax concentration of single medicine is 10, 5, 2.5, 1.25, 0.625 and 0.313 mu g.mL －1, the rose and jasmine concentration of single medicine are 200, 100, 50, 25, 12.5 and 6.25 mu g.mL －1, and each group is provided with 5 parallel compound holes for incubation for 24 hours. After the drug is acted for 24 hours, 100 mu L of basal medium with the final concentration of 16 mmol.L －1Na2S2O4 is added into the model group and the administration group at the same time, and 100 mu L of basal medium 1640 is added into the control group, so that the model is manufactured for 2 hours. Both modeling methods can enable the survival rate of the model group cells to be about 50%. After the completion of the molding, the medium was discarded, and 100. Mu.L of MTT solution having a mass concentration of 0.5 mg.mL －1 was added to each well. After 4h incubation, the supernatant was discarded, 150. Mu.L of DMSO was added to each well and the crystals were dissolved well by shaking for 10 min. Measuring the absorbance of each hole by using an enzyme-labeled instrument, wherein the detection wavelength is 490nm, and calculating the cell activity according to the measured absorbance, thereby reflecting the anti-hypoxia activity of the essential oil.
The experimental results are shown in fig. 1-4, and compared with single monosodium glutamate oil of storax, roses and jasmine, the compound essential oil can obviously increase the survival rate of a PC12 cell damage model induced by sodium dithionite, and the anti-hypoxia activity of the compound essential oil is obvious compared with the single monosodium glutamate oil.
(2) The refreshing efficacy of the compound essential oil in human body is evaluated by the subjective feeling scale of human body:
7 volunteers 20-30 years old are recruited, and a common mask and a mask with compound essential oil are worn for 1h respectively, so that fragrance is kept durable, and subjective feeling evaluation is performed. After wearing, subjective feeling evaluation is carried out on the refreshing efficacy of the compound essential oil, and adverse reactions which occur to the hypoxia symptom are selected as corresponding subjective indexes, wherein as shown in table 1, the higher the score is, the worse the refreshing efficacy is.
TABLE 1 subjective feeling evaluation index of refreshing efficacy
As shown in the experimental result in figure 5, compared with the blank group, the compound essential oil has good improvement effect on indexes such as yawning, strength dizziness, head distention, suffocation, mild chest distress, hypodynamia and the like, and the compound essential oil has the effects of inducing resuscitation and refreshing mind
The embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, and yet fall within the scope of the invention.
Claims (9)
1. The compound essential oil for inducing resuscitation and refreshing mind is characterized by comprising the following preparation raw materials in parts by weight: 1-20 parts of borneol, 1-8 parts of threo essential oil, 10-120 parts of rose essential oil, 1-30 parts of jasmine essential oil and 1-30 parts of benzoin essential oil.
2. The compound essential oil of claim 1, wherein the compound essential oil consists of the following preparation raw materials in parts by weight: 1-5 parts of borneol, 1-3 parts of threo essential oil, 15-25 parts of rose essential oil, 3-9 parts of jasmine essential oil and 3-9 parts of benzoin essential oil.
3. The compound essential oil of claim 1, wherein the compound essential oil consists of the following preparation raw materials in parts by weight: 2.5 parts of borneol, 1 part of threo essential oil, 20 parts of rose essential oil, 5 parts of jasmine essential oil and 5 parts of benzoin essential oil.
4. A method for preparing the compound essential oil according to any one of claims 1 to 3, wherein the preparation raw materials are uniformly mixed.
5. A compound essential oil, characterized by being prepared according to the method of claim 4.
6. The use of a compound essential oil according to any one of claims 1-3 or 5, wherein the compound essential oil is used for preparing a medicament for inducing resuscitation and refreshing.
7. The use of a compound essential oil according to any one of claims 1-3 or 5 for the preparation of an anti-hypoxia drug or hygiene product, characterized in that: the anti-hypoxia medicine is a spray agent composed of compound essential oil, or a civil sanitary product prepared by taking the compound essential oil as an active ingredient and adding conventional auxiliary materials according to the conventional preparation process of traditional Chinese medicines, and comprises a mask and a sachet.
8. An antihypoxic agent characterized in that the active ingredient is a compound essential oil according to any one of claims 1-3 or 5.
9. The antihypoxic according to claim 8, further comprising a pharmaceutically acceptable adjuvant.
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Non-Patent Citations (4)
| Title |
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| 唐永鑫 ; 曾南 ; 倪彩霞 ; 王建 ; 夏厚林 ; .芳香开窍药抗小鼠脑缺血缺氧作用的实验研究.中药与临床.2011,(01),第31-32/41页. * |
| 安息香配伍合成冰片对小鼠脑缺血缺氧及血脑屏障通透性的影响;黄萍;夏厚林;贾芳;黄小燕;宁梓君;唐建军;王建;;中药药理与临床(05);第75-78页 * |
| 芳香开窍药抗小鼠脑缺血缺氧作用的实验研究;唐永鑫;曾南;倪彩霞;王建;夏厚林;;中药与临床(01);第31-32/41页 * |
| 黄萍 ; 夏厚林 ; 贾芳 ; 黄小燕 ; 宁梓君 ; 唐建军 ; 王建 ; .安息香配伍合成冰片对小鼠脑缺血缺氧及血脑屏障通透性的影响.中药药理与临床.2013,(05),第75-78页. * |
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