CN101444546A - Preparation and application of Subing sniffing patch - Google Patents
Preparation and application of Subing sniffing patch Download PDFInfo
- Publication number
- CN101444546A CN101444546A CNA2008100709440A CN200810070944A CN101444546A CN 101444546 A CN101444546 A CN 101444546A CN A2008100709440 A CNA2008100709440 A CN A2008100709440A CN 200810070944 A CN200810070944 A CN 200810070944A CN 101444546 A CN101444546 A CN 101444546A
- Authority
- CN
- China
- Prior art keywords
- patch
- medicine
- sniffing
- subing
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
On the basis of a medicinal patch preparation and traditional Chinese medicine incense bag preparation, together with functional and absorbing mechanism of nasal-cavity-lung medicine feeding and on the basis of the research on storax prescription for treating coronary heart disease, the invention takes Subing dripping pills obtained by using storax and borneol as the research object and uses hydroxypropyl methyl cellulose or other accessories to prepare a traditional Chinese medicine inhaling preparation with a novel dosage form, i.e. a Subing sniffing patch. Concrete prescription of each patch consists of 1-300 mg of storax and 1-300 mg of borneol according to certain proportion. The Subing sniffing patch is mainly characterized in that the patch is only used in terms of conglutination, the medicine does not permeate the skin for absorption; and during the use, one surface of the patch is stuck at the philtrum position below the nostrils, the other surface is coated with a medicine layer which has good volatility and is exposed in the air, and the volatile medicine is inhaled in terms of gas into the lung through the nasal cavity and then enters the systemic circulation, therefore, the aim of curing angina and other cardiovascular diseases is achieved.
Description
Technical field
Patent of the present invention belongs to medicine or field of health care products, relates to sucking preparation novel form--the preparation of-Subing sniffing patch and the content of application.
Patent of the present invention in conjunction with the effect and the absorption mechanism of nasal cavity pulmonary administration, is an object of study with Su Bing on the basis of medicine patch and Chinese medicine sachet agent, makes a kind of sniffing patch novel form of nasal cavity pulmonary administration.This dosage form principal character is that patch is only as bound form, medicine does not play Transdermal absorption, during use, the one side of patch is affixed on " philtrum " position, below, nostril, the medicine layer that it is good that another side scribbles volatility is exposed in the air, by respiratory nasal, volatile medicine is inhaled into the back with the form of gas and arrives pulmonary and enter the body circulation by nasal cavity, reaches the purpose of diseases such as treatment angina pectoris.
Sniffing patch is particularly useful for treating cardiovascular disease and respiratory system disease in conjunction with the advantage of patch and sachet agent, also lays a good foundation for the development of Chinese medicine suction preparation.
Background introduction
Suck preparation mean by specific device with medicament active composition through the oral cavity or nasal cavity transfer to pulmonary to bring into play the preparation of part or general action.Said preparation is injection system one of the most promising route of administration as an alternative, and the structure special with pulmonary is undivided, and alveolar has the surface area suitable with small intestinal, and extent of drug absorption is good, and bioavailability obviously improves.
Sniffing patch, can be described as the fragrant subsides of snuffing fragrance patch or snuffing again, belong to a kind of novel form that sucks preparation, be meant volatile fragrant medicine with patch for adhering to model, be affixed on " philtrum " position under the nose, medicine initiatively sucks the preparation of pulmonary performance part or whole body therapeutic effect through nose with gas form.The patch here is different with classical patch, not as preparation capable of permeating skin, only utilizes the viscosity of patch adhesive-layer to play adhewsive action.Volatile aromatic medicine per nasal sucks, and will arrive pulmonary fast, acts on lesions position without gastrointestinal tract, avoids the effect of liver first pass metabolism, directly produces quick-acting and curative effect efficiently by blood circulation to disease.
Compare with common oral preparation, it is quick-acting and efficiently act on and avoid the liver first-pass effect except the medicine tool to suck preparation, also have the minimizing dosage, alleviate or avoid adverse effect, medicinal liquid should not be by bacterial infection, be convenient for carrying and improve advantage such as patient's compliance.Therefore suck preparation and more and more paid close attention to, become the focus of world market research, present fast development trend by medicament research and development person.
Sniffing patch has tangible advantage: 1. snuffing process does not have the gastrointestinal tract Degradation.The nasal cavity metabolic enzyme is less relatively, and medicine and enzyme are short time of contact, and snuffing process speed is fast, and juice is very little to the destruction of medicine.2. there is not liver first-pass effect.After the medicine via intranasal application is gone into pulmonary's absorption, directly enter the body circulation, avoided liver first-pass effect.3. drug absorption is rapid, and onset time is fast after the administration.The thin intervascular distance of alveolar bullet is 0.5～1 μ m only, the long-pending 200m that reaches of total aborbing surface
2, the blood capillary gross area that contacts with alveolar reaches 100m approximately
2, so medicine arrival pulmonary can be by fast Absorption.4. patient compliance is good, convenient drug administration.Especially for the easy cardiovascular patient that shows effect and need carry out long-term treatment at night, the snuffing administration is more oral more to have superiority.5. side effect is little.The patient can take snuffing fragrance patch off at any time according to curative effect and ability to bear, when guaranteeing effectiveness, reduces side effect.6. dosage is few.The drug absorption that studies have shown that nasal drug delivery system is rapid, only needs 1/10 or 1/15 of oral drugs just to reach effect same.7. timing property preferably.Snuffing fragrance patch used at night, had guaranteed the safety of patient's time period at night, had the release timing property.
Can angina pectoris be the cardinal symptom of coronary heart disease, control anginal attack times and PD, is the key point that prevents myocardial infarction.Common clinically, the multiple and easy fatal diseases of coronary heart disease conduct bring very big harm for the health of mid-aged population, and chest distress is in the life of ecological deterioration, very common especially in current employment pressure anxiety.In population cause of the death cis-position, the cardiovascular diseases has risen to the 2nd, and therefore, cardiovascular disease treating medicine has become the medicine of people's extensive use.
Along with the appearance of viral diseases such as global warming and SARS, add the outbreak of pneumonopathy such as traditional pneumonia, pulmonary tuberculosis, tracheitis, bronchitis, these all directly influence human beings'health, and the infectiousness of respiratory system disease is strong, cause colony to be caught an illness easily.Therefore, the Research Significance of sniffing patch is great, and the research that Chinese medicine is sucked preparation will be played prospective exemplary role.
Because symptoms such as angina pectoris, chest distress often betide night, sniffing patch sticks just before going to bed, tear after getting up, every day 1 time, for prevention with to treat diseases such as nocturnal cardiovascular disease and pulmonary very suitable, both avoided the shortcoming of general suction preparation, and made the patient have better compliance again.
Therefore, belong to the sniffing patch that the nasal cavity inhaled medication is treated cardiovascular or pulmonary disease again,,, have a good application prospect, be worth research and development fully if can put goods on the market with acquisition huge social benefit and economic benefit as a kind of quick-acting Chinese medicine preparation.
Summary of the invention
Subing sniffing patch is that the Subing drop pills that forms with Styrax and Borneolum Syntheticum is the sniffing patch that object of study is made, and tool causing resuscitation with aromatic drugs and regulating QI to relieve pain effect through wide clinical application, reach coronary heart disease to angina pectoris, uncomfortable in chest, myocardial infarction etc. and have good action.
The preparation of Subing sniffing patch of the present invention and application refer to that this sniffing patch only is applied in the nasal cavity pulmonary administration system, the position that patch pasted be lip top, nostril below contain the philtrum position in interior whole zone.
The preparation of Subing sniffing patch of the present invention and application, the Su Bing that wherein relates to, except referring to the sniffing patch that Su Bing prescription (a kind of compound recipe of being made up of Styrax and Borneolum Syntheticum) is made as medicine, in the sniffing patch of composition is also included within jointly with other other medicine (as Moschus, Flos Caryophylli, Herba Menthae etc.) with Styrax (containing certain the concrete composition in the Styrax), these two kinds of medicines of Borneolum Syntheticum or single a kind of medicine wherein.
The preparation of Subing sniffing patch of the present invention and application, its so-called sniffing patch is also referred to as snuffing fragrance patch or the fragrant subsides of snuffing, belong to a kind of novel form that sucks preparation, be meant volatile fragrant medicine with patch for adhering to model, be affixed on " philtrum " position under the nose, medicine is breathed the preparation that initiatively sucks pulmonary performance part or whole body therapeutic effect with gas form through nose.Be embodied in volatile medicine or mixings such as medicine and adjuvant, place on the face mounting the backing material, mount the carrier of backing material as medicine etc., can be cloth, rubber, sponge, foam, paper etc., but the another side of mounting the backing material is also coated the material of tool viscosity, is convenient to be attached to positions such as " philtrums ".The final form of volatile medicine or medicine and adjuvant can be the semisolid of ointment or gel formula, also can be the liquid or the volatile solid of tool of suspensoid, Emulsion, true solution or colloid solution etc.
The preparation of Subing sniffing patch of the present invention and application relate among the Su Bing generally composition by a certain percentage between Styrax 1～300mg and Borneolum Syntheticum 1～300mg of the used dosage of concrete medicine.But the use amount that pharmacopeia, ministry standard or pertinent literature record are mentioned, or through pharmacology or effective other use amount of clinical verification, this patent is suitable for too.
The preparation of Subing sniffing patch of the present invention and application, employed adjuvant comprises all used adjuvants of preparation patch in the Subing sniffing patch prescription that relates to, comprise that also those are suitable for mounting all adjuvants that are used for sniffing patch on backing material two sides, as the hydroxypropyl emthylcellulose of tool viscosity, carbopol, starch, gelatin, paste, polyvinyl alcohol etc., surfactants such as the poly yamanashi esters such as tween 80 of the glycerol of Hydrolyzed Protein effect, sodium carboxymethyl cellulose, starch slurry etc., the effect of tool suspending, arabic gum, also have other type or the like.
The preparation of Subing sniffing patch of the present invention and application, the sniffing patch that relates to is the purpose that reaches the treatment disease by the nasal cavity pulmonary administration, the disease of being controlled mainly refers to cardiovascular disease, also can comprise other new disease of human body, as respiratory system disease, brain diseases etc.
Below in conjunction with embodiment patent of the present invention is described further.
Embodiment 1:
Styrax 10g Borneolum Syntheticum 20g HPMC 100g starch slurry is an amount of
Get 100g HPMC and be sprinkling upon in the beaker that fills 500ml water, heating, be stirred to be transparent glue after, add the appropriate amount of starch slurry, mixing, cooling, standby, be designated as A.Get the 20g Borneolum Syntheticum, add 250ml 70% ethanol and make dissolving, add Styrax again, stir evenly, standby, be designated as B.B is added among the A, and limit edged mixing makes mixture, is affixed on the material of showing to stick one piece of cloth or paper on top of another again, and adds protective layer, promptly gets 1000 Subing sniffing patch.
Embodiment 2:
Styrax 10g Olibanum 10g CMC-Na 50g polyvinyl alcohol is an amount of
Get CMC-Na 50g and be sprinkling upon in the beaker that fills 300ml water, heating, it is an amount of to add polyvinyl alcohol again, be stirred to be transparent glue after, cooling, standby, be designated as A.Get Styrax and add 100ml 70% ethanol and make dissolving, add the Olibanum emulsion that water grinds the back gained again, stir evenly, standby, be designated as B.B is added among the A, and limit edged mixing makes mixture, is affixed on table again and sticks one piece of cloth or paper on top of another on the material, adds protective layer, cut 1000 Styrax sniffing patch.
Description of drawings: accompanying drawing is to illustrate with picture model (not containing protective layer)
Claims (6)
1, the preparation of Subing sniffing patch and application, it is characterized in that: the present invention is on the basis of medicine patch and Chinese medicine sachet agent, effect and absorption mechanism in conjunction with the nasal cavity pulmonary administration, the coronary disease Soviet Union side of closing is being carried out on the basis of research, the Subing drop pills that forms with Styrax and Borneolum Syntheticum is an object of study, use hydroxypropyl emthylcellulose or other adjuvant, make a kind of Chinese medicine and suck preparation novel form---Subing sniffing patch, the recipe quantity of concrete every subsides can be formed between Styrax 1～300mg and Borneolum Syntheticum 1～300mg by a certain percentage.The Subing sniffing patch principal character is that patch is only as bound form, medicine does not play Transdermal absorption, during use, the one side of patch is affixed on " philtrum " position, below, nostril, the medicine layer that it is good that another side scribbles volatility is exposed in the air, by respiratory nasal, volatile medicine is inhaled into the back with the form of gas and arrives pulmonary and enter the body circulation by nasal cavity, reaches the application purpose of cardiovascular disease such as treatment angina pectoris.
2, the preparation of Subing sniffing patch according to claim 1 and application is characterized in that: this sniffing patch only is applied in the nasal cavity pulmonary administration system, the position that patch pasted be lip top, nostril below contain " philtrum " position in interior whole zone.
3, the preparation of Subing sniffing patch according to claim 1 and application, it is characterized in that: Subing drop pills is as object of study, except referring to the sniffing patch that Su Bing prescription (a kind of compound recipe of being made up of Styrax and Borneolum Syntheticum) is made as medicine, in the sniffing patch of composition is also included within jointly with other other medicine (as Moschus, Flos Caryophylli, Herba Menthae etc.) with Styrax (containing certain the concrete composition in the Styrax), these two kinds of medicines of Borneolum Syntheticum or single a kind of medicine wherein.
4, the preparation of Subing sniffing patch according to claim 1 and application, it is characterized in that: so-called sniffing patch is also referred to as snuffing fragrance patch or the fragrant subsides of snuffing, belong to a kind of novel form that sucks preparation, be meant volatile fragrant medicine with patch for adhering to model, be affixed on " philtrum " position under the nose, medicine is breathed the preparation that initiatively sucks pulmonary performance part or whole body therapeutic effect with gas form through nose.Be embodied in volatile medicine or mixings such as medicine and adjuvant, place on the face mounting the backing material, mount the carrier of backing material as medicine etc., can be cloth, rubber, sponge, foam, paper etc., but the another side of mounting the backing material is also coated the material of tool viscosity, is convenient to be attached to positions such as " philtrums ".The final form of volatile medicine or medicine and adjuvant can be the semisolid of ointment or gel formula, also can be the liquid or the volatile solid of tool of suspensoid, Emulsion, true solution or colloid solution etc.
5, the preparation of Subing sniffing patch according to claim 1 and application is characterized in that: the used amount of concrete every subsides medicine is generally formed between Styrax 1～300mg and Borneolum Syntheticum 1～300mg by a certain percentage among the Su Bing.But the use amount that pharmacopeia, ministry standard or pertinent literature record are mentioned, or through pharmacology or effective other use amount of clinical verification, this patent is suitable for too.
6, the preparation of Subing sniffing patch according to claim 1 and application, it is characterized in that: employed adjuvant comprises all used adjuvants of preparation patch in the Subing sniffing patch prescription, comprises that also those are suitable for mounting all adjuvants that are used for sniffing patch on backing material two sides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100709440A CN101444546A (en) | 2008-04-22 | 2008-04-22 | Preparation and application of Subing sniffing patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100709440A CN101444546A (en) | 2008-04-22 | 2008-04-22 | Preparation and application of Subing sniffing patch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101444546A true CN101444546A (en) | 2009-06-03 |
Family
ID=40740619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100709440A Pending CN101444546A (en) | 2008-04-22 | 2008-04-22 | Preparation and application of Subing sniffing patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101444546A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948573A (en) * | 2014-05-05 | 2014-07-30 | 福建中医药大学 | Preparation method of nasal linalool-borneol preparation capable of calming, assisting sleeping and relieving palpitation |
| CN116019860A (en) * | 2022-09-07 | 2023-04-28 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
| CN116196352A (en) * | 2022-09-07 | 2023-06-02 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
-
2008
- 2008-04-22 CN CNA2008100709440A patent/CN101444546A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948573A (en) * | 2014-05-05 | 2014-07-30 | 福建中医药大学 | Preparation method of nasal linalool-borneol preparation capable of calming, assisting sleeping and relieving palpitation |
| CN116019860A (en) * | 2022-09-07 | 2023-04-28 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
| CN116196352A (en) * | 2022-09-07 | 2023-06-02 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
| CN116019860B (en) * | 2022-09-07 | 2024-05-17 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
| CN116196352B (en) * | 2022-09-07 | 2024-05-17 | 威高(北京)医疗科技有限公司 | Compound essential oil with effects of inducing resuscitation and refreshing mind and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2762806T3 (en) | Treatment using mast cell stabilizers for systemic disorders | |
| JP2019031514A5 (en) | ||
| CA3078631A1 (en) | Methods and compositions for topical delivery | |
| JP5841151B2 (en) | Nasal spray | |
| JP2008044951A5 (en) | ||
| US11872258B2 (en) | Oral cavity treatments | |
| JP2012526084A (en) | Pharmaceutical formulation for stabilizing concentrated mast cells | |
| JP2016512833A (en) | Beraprost isomers as therapeutic agents for viral infections | |
| JP2011513437A5 (en) | ||
| JP2016525548A5 (en) | ||
| WO2017135195A1 (en) | Preparation for preventing or treating allergy symptoms | |
| CN103948573A (en) | Preparation method of nasal linalool-borneol preparation capable of calming, assisting sleeping and relieving palpitation | |
| CN101444546A (en) | Preparation and application of Subing sniffing patch | |
| CA3151070A1 (en) | Orally dissolving mucoadhesive films utilizing menthol and l-arginine to enhance the bioavailability of cannabinoids | |
| CA2296231C (en) | Composition and method for treating common viral infections | |
| CN103462942A (en) | Suction-type ambroxol hydrochloride solution | |
| Mishra et al. | Nanocarrier and Herbal Based Transdermal Patch: An Advantage Over Other Drug Delivery Systems | |
| JP2009539893A (en) | Combination wafer | |
| JP5828007B2 (en) | Topically-administered drugs for improving dysphagia | |
| CN103933309A (en) | Method for treating phthisis by inhaling atomized purple garlic liquid | |
| CN101023995A (en) | Novel plaster for treating stamotocace | |
| WO2011064769A1 (en) | Methods and pharmaceutical compositions for the treatment of hot flashes | |
| WO2021195017A1 (en) | Iodine compounds for treating respiratory pathogens | |
| CN1895319A (en) | Use of coronary heart diease synthetic nose fragent paste for nasal-cavity medicine feeding | |
| US20230372389A1 (en) | Inhalation formulation, and preparation method therefor and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20090603 |