CN103908596B

CN103908596B - Traditional Chinese medicament for treating epilepsy

Info

Publication number: CN103908596B
Application number: CN201410157654.5A
Authority: CN
Inventors: 柳少逸
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-04-21
Filing date: 2014-04-21
Publication date: 2017-01-25
Anticipated expiration: 2034-04-21
Also published as: CN103908596A

Abstract

The invention discloses a traditional Chinese medicament for treating epilepsy. The traditional Chinese medicament is prepared from the following components in parts by weight: 10-30 parts of cornu cervi, 10-30 parts of tortoise shell, 10-30 parts of turtle shell, 10-30 parts of pig nails, 10-30 parts of buffalo horn, 10-30 parts of cornu gorais, 10-30 parts of snakegourd seed, 10-30 parts of ochre, 10-30 parts of arisaema cum bile, 10-20 parts of pinellia ternata, 10-20 parts of tabasheer, 10-20 parts of alum, 2-10 centipedes, 10-20 parts of irkutsk anemone rhizome, 2-10 parts of chlorite schist and 2-20 parts of coptis chinensis. The traditional Chinese medicament is prepared according to traditional Chinese medical administration theory, and has the characteristics of scientific compatibility, resuscitation induction and phlegm-sweeping and wind-extinguishing and supplements each other.

Description

A kind of Chinese medicine treating epilepsy

Technical field

The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine treating epilepsy.

Background technology

" epilepsy " or " epilepsy " that epilepsy is commonly called as, is the electric discharge of cerebral neuron paroxysmal abnormality, leads to of short duration A kind of chronic disease of cerebral disorder.Show, the overall prevalence of domestic epilepsy is according to Chinese cri dernier cri disease data 7.0 ‰, annual morbidity is 4.6 ‰ for there being the activeness epilepsy prevalence of outbreak in 28.8/ 10 ten thousand, 1 year.In Chinese epilepsy The second largest commonly encountered diseases having a headache through becoming department of neurology to be only second to.Epilepticss because complexity various, including inherited genetic factorss, brain diseasess, Whole body or systemic disease etc..Its clinical manifestation is also complicated various, can behave as paroxysmal movement, sensation, autonomic nerve, consciousness And mental disorder.Generalized tonic-clonic outbreak, petit mal, grand mal, myoclonic seizure, spasm, mistake tension force is had to send out The dissimilar and mode of onset such as work, simple partial seizure, complex partial seizures, secondary Generalized seizure.Although epilepsy There is no great impact to patient in a short time, but the outbreak of long term frequent may result in the body and mind of patient, intelligence to produce serious shadow Ring, severe patient life threatening.The treatment of epilepsy at present includes Drug therapy, operative treatment, neuromodulation treatment etc., is controlled with medicine Treat as essential therapeutic arsenals.Drug therapy is a long-term practice process, needs doctor and patient and family members to have sufficiently Patience and love.At present clinically, epilepsy had both made through regular Antiepileptic Drugs, also only about 70% patient its Work can obtain control, and wherein some patientss need to be taken medicine throughout one's life.

Content of the invention

It is an object of the invention to improving the deficiency of prior art and providing one kind according to traditional Chinese medical science tradition medication theory, science Arrange in pairs or groups, complement each other, the Chinese medicine for the treatment of epilepsy that inducing resuscitation of having one's ideas straightened out, eliminating phlegm relieve dizziness, high fever, infantile convulsions, epilepsy, etc..

The object of the present invention is achieved like this, a kind of Chinese medicine treating epilepsy, is characterized in that by weight portion be 10-30 part Cornu Cervi Pantotrichum, the Carapax et Plastrum Testudiniss of 10-30 part, the Carapax Trionycis of 10-30 part, the Unguis Sus domestica of 10-30 part, the Cornu Bubali of 10-30 part, 10-30 part Cornu Naemorhedi, the Semen Trichosanthiss of 10-30 part, the Haematitum of 10-30 part, the Arisaema Cum Bile of 10-30 part, the Rhizoma Pinelliae of 10-20 part, 10-20 part Concretio Silicea Bambusae, the Alumen of 10-20 part, 2-10 bar Scolopendra, 10-20 part Rhizoma Anemones Altaicae, the Lapis Chloriti of 2-10 part, the Rhizoma Coptidis group of 2-20 part Become.

The pharmacology that the present invention treats epilepsy is inducing resuscitation of having one's ideas straightened out, eliminating phlegm based on the basic theories of Chinese tradition Chinese medicine Relieve dizziness, high fever, infantile convulsions, epilepsy, etc., wherein:

Cornu Cervi Pantotrichum: warm in nature, salty in the mouth；Return liver and kidney channel.Tonification superintend and direct appoint, blood-nourishing is supporing yang, strengthening the tendons and bones, easing joint movement, reports pure sun Matter, the machine containing hair growth promoting.

Carapax et Plastrum Testudiniss: mild-natured, salty in the mouth, sweet.Return liver and kidney channel.Nourishing YIN for suppressing the hyperactive YANG, reinforcing the kidney to strengthen the bone.Cure mainly deficiency of kidney yin, the lumbago atrophic debility of bones Deng.

Carapax Trionycis: cold nature, salty in the mouth；Return liver and kidney channel.Have nourishing YIN and clearing away heat, YANG hyperactivity suppressing to relieve dizziness, high fever, infantile convulsions, epilepsy, etc., the effect of hard masses softening and resolving.Cure mainly wind syndrome caused by deficiency Interior dynamic, little make infantile convulsion etc..

Unguis Sus domestica: mild-natured, salty in the mouth；Return liver and kidney channel；There is spermatogenesis mends marrow, effect that nourishing YIN relieves dizziness, high fever, infantile convulsions, epilepsy, etc..

Cornu Bubali: cold in nature, bitter in the mouth, salty；GUIXIN, liver, spleen, stomach.There is the effect of heat clearing away, removing heat from blood, removing toxic substances.Cure mainly calentura head Bitterly, infantile convulsion etc..

Cornu Naemorhedi: cool in nature, salty in the mouth；Benefit is superintended and directed and is appointed, nourishing the liver and kidney, and suppressing the hyperactive liver to relieve the wind syndrome is only jerked surely.

Semen Trichosanthiss: cold in nature, sweet in the mouth, slight bitter, puckery；Return lung, stomach, large intestine channel.The special moistening the lung and resolving phlegm of work(, laxation relieving constipation.

Haematitum: mild-natured, bitter but sweet flavor；Return liver, stomach, pericardium channel.Tool suppressing the hyperactive liver town is inverse, cooling blood for hemostasis work(.It is usually used in infantile convulsion Treatment.

Arisaema Cum Bile: cool in nature, bitter in the mouth is trembled with fear, micro-pungent；Return lung, liver, spleen channel.The special removing heat-phlegm of work(, dispelling wind and relieving convulsion.It is usually used in expectorant heat Cough, middle wind-phlegm fan, demented infantile convulsion.

The Rhizoma Pinelliae: warm in nature, acrid in the mouth is poisonous；Enter spleen, stomach.Tool drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass.Water can be manageed it Wet, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.

Concretio Silicea Bambusae: cold in nature, sweet in the mouth, GUIXIN, Liver Channel.There is clear heat and eliminate phlegm, the effect of cool heart arresting convulsion.It is usually used in calentura coma, in Wind-phlegm fan, the hot infantile convulsion of children's expectorant, tic etc..

Alumen: cold in nature, sour-puckery flavor is poisonous；Return lung, spleen, liver, large intestine, bladder warp.Tool expectorant dampness, antidiarrheal hemostasis, removing toxic substances The effect of parasite killing.Commonly use and control epilepsy, dysentery, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies etc..

Scolopendra: warm in nature, acrid in the mouth is poisonous；Return liver warp.Work(main endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.It is used for children Infantile convulsion, tic spasm, middle air port are askew, hemiplegia etc..

Rhizoma Anemones Altaicae: warm in nature, acrid in the mouth；GUIXIN, liver, spleen channel.There is waking up the patient from unconsciousness by dissipating phlegm to calm the nerves, declare the effect of wet removing toxic substances of being amusing.Cure mainly heat Sick coma, epilepsy etc..

Lapis Chloriti: mild-natured, sweet in the mouth, salty, nontoxic；Return lung, the heart, liver, stomach, large intestine channel.Have pendant the expectorant therapeutic method to keep the adverse QI flowing downwards, suppressing the hyperactive liver arresting convulsion, Help digestion and attack long-pending work(.Cure mainly pertinacious phlegm cough with asthma, epilepsy is gone mad, the card such as convulsion with spasms.

Rhizoma Coptidis: cold in nature, bitter in the mouth；GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.The special heat clearing and damp drying of work(, eliminating fire and detoxication.It is used for wet Fullness-oppression in the epigastrium caused by heat is full, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire etc..

Prescription pharmacology of the present invention is: Carapax et Plastrum Testudiniss, Carapax Trionycis, Unguis Sus domestica spermatogenesis mends marrow, and nourishing YIN relieves dizziness, high fever, infantile convulsions, epilepsy, etc.；Cornu Cervi Pantotrichum tonification is superintended and directed and is appointed, and gives birth to and brings up Brains；Cornu Bubali, Cornu Naemorhedi benefit are superintended and directed and are appointed nourishing the liver and kidney, suppressing the hyperactive liver to relieve the wind syndrome, only surely jerk；Semen Trichosanthiss resolving sputum relieving constipation；Haematitum suppressing the hyperactive liver town is inverse； Arisaema Cum Bile removing heat-phlegm, dispelling wind and relieving convulsion；Rhizoma Pinelliae drying dampness to eliminate phlegm；Concretio Silicea Bambusae clear heat and eliminate phlegm, cool heart arresting convulsion；Alumen expectorant dampness；Wu Centipede endogenous wind stopping spasmolytic dredging collateral；Rhizoma Anemones Altaicae waking up the patient from unconsciousness by dissipating phlegm is calmed the nerves；Lapis Chloriti eliminating phlegm suppressing the hyperactive liver is calmed the frightened；Rhizoma Coptidis heat clearing and damp drying.

The present invention is made up of the Chinese herbal medicine of Chinese tradition, according to the pathological characteristic of epilepticss, develops.Epilepticss Basic reason is that clear key is disturbed, and refreshing machine is at random, and unit god loses and supports, and brain is not filled, and the weary machine of brain god is then fallen forward and twitched dusk, absentminded.Kidney Store essential substances, heart storing spirit, burnt, liver controlling conveyance and dispersion in spleen fortune, spleen kidney deficiency and raw expectorant, irritability is prosperous and raw wind.Dysfunction of the spleen in transportation, accumulatively wet raise phlegm, one Meet inducement, expectorant is turbid or with QI rising in reverse order, or with pneumatic, or because fire is scorching, blind refreshing thinking, sending out is epilepsy syndrome.Its feature is mainly shown as soldier So fall forward with shriek, do not know people, slobbering, the eyes turning upwards dusk, limbs are twitched, revival recurrent exerbation during shifting.Have one's ideas straightened out awake God, eliminating phlegm relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and make laws for main.

The prescription of the present invention is to tackle the problem at its root to the effect of this disease, and inducing resuscitation of having one's ideas straightened out, eliminating phlegm relieve dizziness, high fever, infantile convulsions, epilepsy, etc..Three Month it is a course for the treatment of, a general course for the treatment of takes effect, three courses for the treatment of are visible to be obviously improved, and six course for the treatment of functions are substantially recovered or fully recovered.

The present invention be oral medicine, have no toxic side effect, medication for many years, the no any untoward reaction of patient, follow the tracks of blood test Normally, and curative effect does not rebound.

The animal toxicology experiment summary of Chinese medicine of the present invention: purpose is to observe rat to take the acute of this prescription and long term toxicity orally Effect.Method: have sd rat be study subject, take 4 dosage (40,20,10,5ml/kg), give powder and continuously feed 540 My god, after the growth promoter of rat when observing administration 90-540 days, blood, blood biochemical and drug withdrawal 30-180 days, rat body weight, Food ration, activity, peripheral hemogram, important organ coefficient are all normal.Biochemical analysis index: each administration group compares with blank group, in vain Albumen reduces (p ＞ 0.05), and total protein and creatinine raise (p ＞ 0.05), and alkali phosphatase (alp) raises (p ＞ 0.05).Conclusion Long_term toxcity experiment represents: during taking this prescription medication orally, the observation of indices reaction, and have no that substantially poison is secondary and make With.Comprehensive analysis think: under prescribed dose, application is safe and reliable to this prescription.

The prescription of the present invention, regardless of multiple patient, medication substantially takes effect for three months.The outbreak cycle is obviously prolonged, clinical Symptom substantially mitigates.General 3～6 courses for the treatment of realize target.

100 patients, treatment group 100 are treated using Chinese medicine clinical practice of the present invention, using the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of this prescription, grinds Smalls warm boiled water, services once sooner or later by 6 grams every time.Matched group 100, using carbamazepine, daily 1～2 time, every time 100mg～200mg.No matter total effective rate and obvious effective rate, treatment group compared with matched group, significant difference.Through statistics unity and coherence in writing Process p ＜ 0.05；Total effective rate treatment group is 96%, and matched group is 71%；Obvious effective rate treatment group is 84%, and matched group is 54%.Under Table is the therapeutic evaluation after treatment group and treatment of control group:

__________________

Group number of cases effective enabledisable death total effective rate

__________________

Treatment group 100 84 12 40 96%

Matched group 100 54 17 29 0 71%

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P ＜ 0.05.

Specific embodiment

With reference to embodiment, the present invention is described in further detail.

Embodiment 1, a kind of Chinese medicine treating epilepsy, by 10 grams of Cornu Cervi Pantotrichum, 10 grams of Carapax et Plastrum Testudiniss, 10 grams of Carapax Trionycis, 10 grams of Unguis Sus domestica, water 10 grams of Cornu Bovis seu Bubali, 10 grams of Cornu Naemorhedi, 20 grams of Semen Trichosanthiss, 15 grams of Haematitum, 20 grams of Arisaema Cum Bile, 10 grams of the Rhizoma Pinelliae, 20 grams of Concretio Silicea Bambusae, Alumen 18 Gram, Scolopendra 10,15 grams of Rhizoma Anemones Altaicae, 6 grams of Lapis Chloriti, 20 grams of Rhizoma Coptidis composition.

Embodiment 2, a kind of Chinese medicine treating epilepsy, by 15 grams of Cornu Cervi Pantotrichum, 15 grams of Carapax et Plastrum Testudiniss, 15 grams of Carapax Trionycis, 15 grams of Unguis Sus domestica, water 15 grams of Cornu Bovis seu Bubali, 15 grams of Cornu Naemorhedi, 30 grams of Semen Trichosanthiss, 20 grams of Haematitum, 30 grams of Arisaema Cum Bile, 20 grams of the Rhizoma Pinelliae, 15 grams of Concretio Silicea Bambusae, Alumen 15 Gram, Scolopendra 8,20 grams of Rhizoma Anemones Altaicae, 8 grams of Lapis Chloriti, 20 grams of Rhizoma Coptidis composition.

Embodiment 3, a kind of Chinese medicine treating epilepsy, by 20 grams of Cornu Cervi Pantotrichum, 20 grams of Carapax et Plastrum Testudiniss, 20 grams of Carapax Trionycis, 20 grams of Unguis Sus domestica, water 20 grams of Cornu Bovis seu Bubali, 20 grams of Cornu Naemorhedi, 30 grams of Semen Trichosanthiss, 30 grams of Haematitum, 20 grams of Arisaema Cum Bile, 20 grams of the Rhizoma Pinelliae, 20 grams of Concretio Silicea Bambusae, Alumen 20 Gram, Scolopendra 10,20 grams of Rhizoma Anemones Altaicae, 10 grams of Lapis Chloriti, 20 grams of Rhizoma Coptidis composition.

Embodiment 4, a kind of Chinese medicine treating epilepsy, by 30 grams of Cornu Cervi Pantotrichum, 30 grams of Carapax et Plastrum Testudiniss, 30 grams of Carapax Trionycis, 30 grams of Unguis Sus domestica, water 30 grams of Cornu Bovis seu Bubali, 30 grams of Cornu Naemorhedi, 30 grams of Semen Trichosanthiss, 30 grams of Haematitum, 30 grams of Arisaema Cum Bile, 15 grams of the Rhizoma Pinelliae, 20 grams of Concretio Silicea Bambusae, Alumen 20 Gram, Scolopendra 6,20 grams of Rhizoma Anemones Altaicae, 8 grams of Lapis Chloriti, 20 grams of Rhizoma Coptidis composition.

Embodiment 5, a kind of Chinese medicine treating epilepsy, by 30 grams of Cornu Cervi Pantotrichum, 30 grams of Carapax et Plastrum Testudiniss, 30 grams of Carapax Trionycis, 30 grams of Unguis Sus domestica, water 30 grams of Cornu Bovis seu Bubali, 30 grams of Cornu Naemorhedi, 30 grams of Semen Trichosanthiss, 20 grams of Haematitum, 30 grams of Arisaema Cum Bile, 20 grams of the Rhizoma Pinelliae, 20 grams of Concretio Silicea Bambusae, Alumen 20 Gram, Scolopendra 6,20 grams of Rhizoma Anemones Altaicae, 6 grams of Lapis Chloriti, 20 grams of Rhizoma Coptidis composition.

Embodiment 6, a kind of Chinese medicine treating epilepsy, be by 10 grams Cornu Cervi Pantotrichum, 30 grams of Carapax et Plastrum Testudiniss, 10 grams of Carapax Trionycis, 30 grams Unguis Sus domestica, 10 grams of Cornu Bubali, 30 grams of Cornu Naemorhedi, 10 grams of Semen Trichosanthiss, 30 grams of Haematitum, 10 grams of Arisaema Cum Bile, 20 grams The Rhizoma Pinelliae, 10 grams of Concretio Silicea Bambusae, 20 grams of Alumen, 2 Scolopendras, 20 grams of Rhizoma Anemones Altaicaes, 2 grams of Lapis Chloriti, 20 grams Rhizoma Coptidis composition.

Embodiment 7, a kind of Chinese medicine treating epilepsy, be by 30 grams Cornu Cervi Pantotrichum, 10 grams of Carapax et Plastrum Testudiniss, 30 grams of Carapax Trionycis, 10 grams Unguis Sus domestica, 30 grams of Cornu Bubali, 10 grams of Cornu Naemorhedi, 30 grams of Semen Trichosanthiss, 10 grams of Haematitum, 30 grams of Arisaema Cum Bile, 10 grams The Rhizoma Pinelliae, 20 grams of Concretio Silicea Bambusae, 10 grams of Alumen, 10 Scolopendras, 10 grams of Rhizoma Anemones Altaicaes, 10 grams of Lapis Chloriti, 2 grams of Rhizoma Coptidis groups Become.

Concrete case:

Wang, man, 29 years old, Laiyang Shandong Province people.Dashed forward in work before half a year sense nausea, dizziness, headache, tinnitus, nervous, wink Breath is confused to fall forward, and slobbering, extremity are twitched, a moment regains consciousness, and just like ordinary person, sense is extremely tired out after being ill, and the moon is remaining thereafter and sends out once, closely First quarter moon come to show effect relatively frequency, or three, five days one, or six, seven days one.Very fear it, thus to hospital, it is diagnosed as " insane through doctor trained in Western medicine Epilepsy " petit mal, and turn Chinese traditional treatment.Look into pale complexion, lassitude and lack of spirit, hair is withered.Past have seminal emission, forgetful, lumbago medical history.Tongue Light white thin coating, deep,thready and forceless pulse, two chis are more so.Using three doses of our medicine, after medication 100 days, the outbreak cycle is obviously prolonged, and 20 Yu Yi sends out；After with five doses, February is not sent out, and is discontinued.Follow-up is not recurred for 2 years.

Clothing, female, 32 years old.Laiyang Shandong Province people.Epilepsy, lasts more than year, sends out irregular.Dizziness and headache before sending out, with breast Vexed lose heart, then swoon fall forward, unconsciousness, gnathospasma, face and limbs twitch, during shifting revive.Element week, heavy sensation of the body, and spirit is withered Waste, speech is as usual.Abdominal part and both arms have more than 10 pieces of soybean grain greater tubercle, check in 145 hospitals subcutaneous nodule vivisections, examine for Cerebral cysticercosiss outbreak epilepsy.Pale tongue greasy coating, deep and stringy pulse.Using five doses of our medicine, after medication half a year, more than the moon, do not send out drug withdrawal. Follow-up is not recurred for 2 years.

Claims

1. a kind of Chinese medicine treating epilepsy, it is characterized in that by weight portion be the Cornu Cervi Pantotrichum of 10-30 part, the Carapax et Plastrum Testudiniss of 10-30 part, 10-30 The Carapax Trionycis of part, the Unguis Sus domestica of 10-30 part, the Cornu Bubali of 10-30 part, the Cornu Naemorhedi of 10-30 part, the Semen Trichosanthiss of 10-30 part, 10- 30 parts of Haematitum, the Arisaema Cum Bile of 10-30 part, the Rhizoma Pinelliae of 10-20 part, the Concretio Silicea Bambusae of 10-20 part, the Alumen of 10-20 part, 2-10 bar Scolopendra, 10-20 part Rhizoma Anemones Altaicae, the Lapis Chloriti of 2-10 part, the Rhizoma Coptidis composition of 2-20 part.