CN114796095A - Sleep-aiding compound plant essential oil - Google Patents
Sleep-aiding compound plant essential oil Download PDFInfo
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- CN114796095A CN114796095A CN202210478658.8A CN202210478658A CN114796095A CN 114796095 A CN114796095 A CN 114796095A CN 202210478658 A CN202210478658 A CN 202210478658A CN 114796095 A CN114796095 A CN 114796095A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention belongs to the technical field of medicines, and discloses sleep-aiding compound plant essential oil. Calculated by volume percentage, the plant essential oil is compounded by the following plant essential oils: 1-5% of blumea oil, 30-50% of sweet orange oil, 15-25% of lavender oil, 15-25% of rose oil and 15-25% of rosemary oil. The inclusion technology is adopted to prepare the nano preparation which is applied to an air humidifier. The sleep quality can be improved, the fatigue can be relieved, and the traditional Chinese medicine composition has the advantages of no toxic or side effect, safety, reliability, pleasant fragrance, long-term use and obvious curative effect.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to sleep-aiding compound plant essential oil and a preparation method thereof.
Background
It is well known that sleep is important for human beings, and it can not only restore physical strength and energy, and make the body and brain return to the optimum state, but also resist diseases and enhance immunity of the body. Therefore, adequate sleep time and good sleep quality are particularly important. However, in such a fast paced, highly competitive, high-stress state of life, sleep appears to be a luxury item, and more people suffer from insufficient sleep time and poor quality. At present, the main method for clinically improving the sleep quality is to take hypnotics and tranquilizers for treatment, although the hypnotics and the tranquilizers have good sedative effect on central nerves, the long-term taking of the sedative drugs can cause toxic effect on the central nervous system, and the phenomena of poor mental state, inappetence, hypomnesis and the like are generated. Therefore, a new treatment means is urgently to be found to improve the current clinical condition, improve the sleep quality of the patient and relieve the mind and body.
Plant essential oils are, in a broad sense, a generic term for volatile substances obtained by processing and extraction from plants. The pure natural plant essential oil has fragrant smell, and can stimulate the anterior lobe of the brain to secrete two hormones, namely endorphin and enkephalin, after entering the brain, so that the spirit is in a comfortable state. Because the molecular chains of essential oils are usually relatively short, they are highly permeable to the skin and enter the body via the abundant capillaries under the subcutaneous fat.
Based on the current situation, the characteristics of different plant essential oils are utilized to prepare the compound sleep essential oil from the blumea oil, the sweet orange oil, the lavender oil, the rose oil and the rosemary oil, and the nano preparation for the humidifier is prepared by adopting a coating technology, so that the sleep quality is improved, and no relevant report is found at present.
Disclosure of Invention
The invention aims to solve the technical problems that sedative drugs in the existing clinical sleep disorder treatment problem have large side effects and are easy to tolerate, and develops the sleep-aiding compound plant essential oil.
The invention is realized by the following technical scheme:
the sleep-aiding compound plant essential oil comprises the following components in percentage by volume: 1-5% of blumea oil, 30-50% of sweet orange oil, 15-25% of lavender oil, 15-25% of rose oil and 15-25% of rosemary oil.
Slowly dripping the sleep-aiding compound plant essential oil prepared by the formula into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin, stirring, heating, reacting, evaporating a solvent by adopting a reduced pressure rotary evaporation method after the reaction is finished, and drying to prepare the nano preparation. It is applied to an air humidifier.
The argyi leaf oil is extracted from the herbaceous plant argyi leaf, and modern pharmacological experimental data prove that the argyi leaf oil has the effects of resisting tumor, resisting allergy, relieving cough and relaxing bronchus, has an obvious sedative effect, can obviously prolong the sleep time of pentobarbital, and has important effects of improving anxiety and treating insomnia.
The sweet orange oil has tranquilizing effect, and can relax nerves, relieve stress, maintain physical and mental pleasure, enhance vitality, relieve tension and stress, and relieve insomnia caused by anxiety. In addition, the product has effects of moisturizing skin, removing odor, preventing common cold, and promoting growth and repair of body tissue.
The lavender essential oil is used for treating nervous system diseases such as migraine, anxiety, depression and the like, and the modern research data proves that the lavender essential oil can obviously relieve the anxiety, reduce sleep disorder and depression and has no withdrawal symptoms and toxic and side effects.
The oleum Rosae Rugosae is prepared by steam distilling fresh flos Rosae Rugosae, and the oleum Rosae Rugosae can be used for preventing infectious diseases, treating dermatosis, and regulating endocrine. The natural fragrance of the medicine enters human body through olfactory nerve, so that the people can feel comfortable, joyful and pleasant, relieve anxiety, depression and pressure, help sleep, and promote metabolism, cell regeneration and blood circulation.
Rosemary oil has stimulating effect on brain and central nervous system, and can improve memory; can be used for treating headache, migraine, neuralgia, mental fatigue and neurasthenia.
The principle of the invention is as follows: each plant essential oil has a chemical structure to determine its flavor, color, fluidity and its mode of operation with the system, and each plant essential oil has a specific set of functional characteristics. Different essential oils can be combined with each other to prepare different fragrances, so that the characteristics of the essential oils are not damaged, and the functions of the essential oils are promoted. The invention adopts aromatherapy, utilizes the characteristic that essential oil is composed of very small molecules and is easy to volatilize, takes air as a carrier, absorbs the essential oil into a body through mucous membrane tissues of a nasal cavity, directly sends information to a brain, regulates emotion and physiology through a peripheral system of the brain, strengthens physiological and psychological functions, and improves sleep quality.
The invention has the advantages that:
the invention adopts pure plant to extract essential oil, compounds the essential oil according to the characteristics of different plant essential oils, and comprises the essential oil into a nano preparation which is applied to a humidifier and permeates organisms through breathing, so that the sleep quality can be obviously improved. The formula is pure natural, has no additive, is safe and nontoxic, has aromatic smell and obvious curative effect, and can be used for a long time.
Detailed Description
In order to more clearly and completely describe the technical scheme included in the invention, the invention is described in detail below.
Example 1
According to the formula, 5% of argy wormwood leaf oil, 50% of sweet orange oil, 15% of lavender oil, 15% of rose oil and 15% of rosemary oil are taken to be placed in the same container to be stirred at a high speed under the condition of normal temperature and normal pressure to form sleep-aiding essential oil with uniform texture, and then the sleep-aiding essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 2
According to the formula, 5% of argyi leaf oil, 41% of sweet orange oil, 18% of lavender oil, 18% of rose oil and 18% of rosemary oil are placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 3
According to the formula, 4% of argyi leaf oil, 42% of sweet orange oil, 18% of lavender oil, 18% of rose oil and 18% of rosemary oil are taken to be placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 4
According to the formula, 3% of argyi leaf oil, 43% of sweet orange oil, 18% of lavender oil, 18% of rose oil and 18% of rosemary oil are taken to be placed in the same container to be stirred at a high speed under the condition of normal temperature and normal pressure to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 5
According to the formula, 2% of argy wormwood leaf oil, 44% of sweet orange oil, 18% of lavender oil, 18% of rose oil and 18% of rosemary oil are taken to be placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 6
According to the formula, 1% of blumea oil, 45% of sweet orange oil, 18% of lavender oil, 18% of rose oil and 18% of rosemary oil are taken to be placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The nanometer preparation of the compound plant sleep-aiding essential oil is proved by experiments to be capable of obviously improving the quality of insomnia and relieving anxiety, and the acceptance of people with odor is high.
Example 7
According to the formula, 5% of argyi leaf oil, 35% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil are placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 8
According to the formula, 4% of argy wormwood leaf oil, 36% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil are placed in the same container and stirred at a high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 9
According to the formula, by volume percentage, under the conditions of normal temperature and normal pressure, 3% of blumea oil, 37% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil are placed in the same container and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 10
According to the formula, 2% of argy wormwood leaf oil, 38% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil are taken to be placed in the same container by volume percentage and stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Example 11
According to the formula, 1% of argyi leaf oil, 39% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil are taken to be placed in the same container and stirred at a high speed under the condition of normal temperature and normal pressure to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place, sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil, slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2 of the compound essential oil to the hydroxypropyl-beta-cyclodextrin, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by using a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nanometer preparation is proved by experiments to be capable of remarkably improving the quality of insomnia and relieving anxiety, and the smell of the compound plant sleep-aiding essential oil nanometer preparation is high in acceptance of people.
Comparative example 1
According to volume percentage, under the condition of normal temperature and pressure, 15 percent of blumea oil, 39 percent of sweet orange oil, 23 percent of rose oil and 23 percent of rosemary oil are taken to be placed in the same container to be stirred at high speed to form sleep essential oil with uniform texture, and then the sleep essential oil is placed in a shade place to be sealed, shaded, subpackaged and stored. Taking the prepared compound plant sleep-aiding essential oil according to the compound essential oil; slowly adding the compound essential oil into a saturated absolute ethyl alcohol solution of hydroxypropyl-beta-cyclodextrin according to the weight ratio of 1: 2, stirring and reacting at the constant temperature of 45 ℃ for 3 hours, evaporating the solvent by a rotary evaporator at the temperature of 60 ℃, and further drying by using an oven at the temperature of 60 ℃. The compound plant sleep-aiding essential oil nano preparation is obtained, and experiments prove that the formula has poor insomnia improvement quality, is inferior to the formula described in the above embodiment for relieving anxiety, and has low acceptance of people with odor.
Comparative example 2
The commercialized nerve-soothing and brain-nourishing liquid is taken by test people according to the specification in time and quantity, and after a treatment period, the result shows that the formula effect provided by the invention is equal to that of the nerve-soothing and brain-nourishing liquid, the sleep quality can be effectively improved, the anxiety can be relieved, and the invention has no side effect.
The test results of the compound plant essential oil for improving sleep quality provided by the invention are as follows:
the specific test-participating objects need to satisfy the following conditions: the Pittsburgh Sleep Quality Index (PSQI) is between 10 and 21; ② the diagnosis of the primary insomnia is based on Chinese guidelines for adult insomnia diagnosis and treatment; ③ age 18-50 years old; fourthly, the vital signs are stable, the mind is clear, no alcoholism and addiction exist, and the pregnant women, the lactating women and the epileptic are not pregnant.
The test method comprises the following steps: 100 patients with sleep disorders meeting the above standards are selected for testing, and test population receives the sleep-aiding compound essential oil nano preparation before falling asleep, and the sleep-aiding compound essential oil nano preparation acts through a humidifier to treat the sleep disorder for 30 minutes. The compound essential oil in each embodiment is tested by 100 persons in three rounds, the use period is 28 days as a treatment course, and patients who do not need to rely on the compound essential oil after the treatment course can achieve better sleep quality improvement so as to achieve good treatment effect.
The test results are shown in the following table:
in the test, the medicine has better curative effect of improving the sleep disorder for the primary insomnia patients between 18 and 50 years of age. After more than 90% of insomnia patients who are tested use the compound plant essential oil for one treatment course, the compound plant essential oil can obviously improve the troubles of poor sleep quality and difficulty in falling asleep, can relieve pressure and relieve tired mood, and also has great improvement on the sleep patients who are stressed due to anxiety. The sleep improving effect is poor after the proportion of the blumea oil is increased and the proportion of the lavender oil is reduced; compared with commercial nerve-soothing and brain-nourishing liquid, the plant essential oil disclosed by the invention has the same formula effect, and the patient compliance is greatly improved: according to the reaction of the tested population, the sleep-aiding compound plant essential oil provided by the invention has pleasant smell, high general acceptance and no adverse reaction, can obviously relieve fatigue, soothe the whole body and effectively improve the insomnia quality.
Claims (4)
1. The sleep-aiding compound plant essential oil is characterized in that: the plant essential oil is compounded by the following plant essential oils in percentage by volume: 1-5% of blumea oil, 30-50% of sweet orange oil, 15-25% of lavender oil, 15-25% of rose oil and 15-25% of rosemary oil.
2. The sleep-aiding compound plant essential oil as claimed in claim 1, which is characterized in that:
the plant essential oil is compounded by the following plant essential oils in percentage by volume: 1-3% of blumea oil, 37-39% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil.
3. The sleep-aiding compound plant essential oil as claimed in claim 2, which is characterized in that: the plant essential oil is compounded by the following plant essential oils in percentage by volume: 1% of argy wormwood leaf oil, 39% of sweet orange oil, 20% of lavender oil, 20% of rose oil and 20% of rosemary oil.
4. A sleep aid compound plant essential oil as claimed in any one of claims 1 to 3, wherein: mixing it with hydroxypropyl-beta-cyclodextrin in a ratio of 1: 2 weight ratio to prepare the fumigant for the air humidifier.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120052139A1 (en) * | 2009-05-19 | 2012-03-01 | Byeong Bae Jeon | Fragrance composition having good sleep-inducing effect |
| CN111973672A (en) * | 2020-09-11 | 2020-11-24 | 杜浩 | Sleep-aiding composition and preparation method thereof |
| CN112516212A (en) * | 2020-11-30 | 2021-03-19 | 南方医科大学 | Compound essential oil for improving sleep and application thereof |
| TW202210092A (en) * | 2020-09-04 | 2022-03-16 | 植享家股份有限公司 | Use of an compound essential oil on cognitive function, quality of sleep and improve mood by using sniffing. |
| CN114288421A (en) * | 2022-01-12 | 2022-04-08 | 郑州大学 | Folium artemisiae argyi essential oil nanometer preparation and preparation method and application thereof |
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2022
- 2022-04-29 CN CN202210478658.8A patent/CN114796095A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120052139A1 (en) * | 2009-05-19 | 2012-03-01 | Byeong Bae Jeon | Fragrance composition having good sleep-inducing effect |
| TW202210092A (en) * | 2020-09-04 | 2022-03-16 | 植享家股份有限公司 | Use of an compound essential oil on cognitive function, quality of sleep and improve mood by using sniffing. |
| CN111973672A (en) * | 2020-09-11 | 2020-11-24 | 杜浩 | Sleep-aiding composition and preparation method thereof |
| CN112516212A (en) * | 2020-11-30 | 2021-03-19 | 南方医科大学 | Compound essential oil for improving sleep and application thereof |
| CN114288421A (en) * | 2022-01-12 | 2022-04-08 | 郑州大学 | Folium artemisiae argyi essential oil nanometer preparation and preparation method and application thereof |
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