CN109432318B - Compound essential oil, application thereof and compound essential oil product - Google Patents

Compound essential oil, application thereof and compound essential oil product Download PDF

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CN109432318B
CN109432318B CN201811534382.0A CN201811534382A CN109432318B CN 109432318 B CN109432318 B CN 109432318B CN 201811534382 A CN201811534382 A CN 201811534382A CN 109432318 B CN109432318 B CN 109432318B
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刘月帅
易斌
肖艳皎
罗丽莲
韩雅慧
田军
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Beijing Silian Pharmaceutical Industry Co ltd
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Abstract

The invention relates to the technical field of traditional Chinese medicine health care, in particular to compound essential oil, application thereof and a compound essential oil product. The compound essential oil comprises the following components in parts by volume: 1-10 parts of geranium oil, 1-5 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil and 1-3 parts of bergamot oil. According to the invention, the stock solution of the pure natural plant essential oil is reasonably compatible, and the scientific proportion ratio is combined, so that the synergistic effect is achieved, and the obtained compound essential oil has a good fatigue relieving effect.

Description

Compound essential oil, application thereof and compound essential oil product
Technical Field
The invention relates to the technical field of traditional Chinese medicine health care, in particular to compound essential oil, application thereof and a compound essential oil product.
Background
Modern people often suffer from listlessness and excessive fatigue in the daytime due to bad living habits, such as long-term staying up at night, irregular diet, high psychological stress and the like. Particularly, with the change of air temperature, such as sultry summer, people can feel faint in the head, and the head is often attacked by sleepiness in the face of heavy learning and working tasks, so that the eyes are distracted, the spirit is not shaken, and the working efficiency naturally and linearly drops. The harm of listlessness and fatigue is also shown in the following aspects:
(1) accelerating aging
Long-term fatigue and listlessness can destroy the endocrine and the normal circulation of the nervous system of the human body, cause nervous system disorder, accelerate the aging of the human body, and appear on the skin, and the problems of rough skin, yellowish complexion, color spots, poor elasticity, lack of luster and the like are easy to appear.
(2) Influence on work efficiency
The sympathetic nerves of the tired and impatient are difficult to excite sufficiently, so there are no phenomena of mental, dizziness, hypomnesis, inattention, reaction retardation, amnesia, etc. in the daytime. And over time, may further cause symptoms such as neurasthenia, insomnia, etc. For common workers, the work efficiency is reduced due to lassitude, but for high-risk industrial workers, the work efficiency is reduced due to fatigue and lassitude, and greater risks are brought to cause accidents, such as fatigue driving and various accidents like fire explosion.
(3) Resistance decline and physical weakness
Under the conditions of fatigue and lassitude, the human body is usually tired, so that various activities are reduced, the rules of rest and movement of the human body can be destroyed in the long-term past, heartbeat disorder, palpitation and weakness and other phenomena are easily caused, the normal physiological cycle of the human body and the normal reaction system of the human body are destroyed, the resistance is reduced, and various diseases are further caused.
Therefore, in order to improve and overcome the phenomena of fatigue and lassitude, many countermeasures are also taken, mainly including the following items:
(1) adequate and regular sleep
For most people, at least 6 hours of sleep are guaranteed in one day, and sufficient sleep can keep people alive in the daytime.
(2) Refreshing beverage such as coffee and tea
The alkaloids in tea and coffee can stimulate cranial nerve to form mental excitation, and has refreshing and refreshing effects. However, proper drinking should be paid attention to avoid the persistent spiritual excitement caused by drinking a large amount.
(3) Proper amount of exercise
After a proper amount of exercise, the brain is usually more awake and the spirit is in a state of being excited, and the method has the defect that the method is difficult to implement, especially for people who work on a table for a long time.
(4) Olfactory stimulation
Can also achieve refreshing effect by stimulating smell, and can stimulate smell and skin with fragrance and cool smell to improve feelings of fatigue and nerve weakness, such as herba Agastaches water, floral water, cooling oil, and essential balm. However, the disadvantages are that many people are not suitable for special smells of essential balm, cooling oil and the like, and the substances have certain irritation to the skin when being applied.
Essential oils are volatile aromatic substances extracted from flowers, leaves, stems, roots or fruits of plants by steam distillation, extrusion, cold soaking or solvent extraction. These volatile substances can be absorbed by the mucosal tissue of the nasal cavity and enter the body, sending messages directly to the brain, and regulating the emotion and physiological functions of the body through the limbic system of the brain. Therefore, the essential oil can strengthen physiological and psychological functions, and has the functions of tranquilizing and hypnotizing, relieving fatigue, exciting and refreshing, adjusting mental status, resisting depression, relieving psychological stress, repairing nervous system and the like.
The plant essential oil has the advantages of high safety, quick metabolism, no residue in vivo, simple, flexible and various using methods, capability of being operated by an inhalation method, a fumigation method, a massage method and the like according to personal preference and requirements, and suitability for developing products for relieving fatigue. However, the existing fatigue relieving essential oil has poor effects of relieving fatigue, refreshing and restoring consciousness and revivifying due to lack of scientificity in component selection or proportion, the fragrance of the essential oil is monotonous, and the crowd acceptance is not high.
Disclosure of Invention
In view of the above, the invention provides compound essential oil, application thereof and a compound essential oil product. The compound essential oil is prepared by reasonably mixing the stock solution of the pure natural plant essential oil and combining with a scientific proportion ratio, so that the synergistic effect is achieved, and the obtained compound essential oil has a good fatigue relieving effect.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides compound essential oil which comprises the following components in parts by volume:
1-10 parts of geranium oil, 1-5 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil and 1-3 parts of bergamot oil.
The geranium essential oil contains citronellol, citronellyl formate, terpinene, geranic acid, geraniol, terpineol, citral, menthone and various trace mineral elements, can relieve pain, astringe and resist bacteria, smooth anxiety and depression, improve emotion, influence adrenal cortex, restore mental balance and relieve stress.
The cedar essential oil has a delicate woody faint scent, contains cedrol, is mild in nature, has the effects of diminishing inflammation, resisting bacteria, astringing, promoting urination, softening, reducing phlegm and killing mold, and has a good soothing effect on nervous tension and anxiety states.
The jasmine essential oil has elegant smell, and can relieve depression, refresh mind, promote self-confidence, and care and improve skin dryness, water deficiency, oil passing and sensitivity.
The lemon essential oil can improve the function of a circulatory system, promote blood circulation, strengthen an immune system, purify the body and improve the function of a digestive system, has the functions of soothing and relieving headache and migraine, and has the functions of refreshing, restoring consciousness, exciting spirit, relieving dysphoria and purifying air.
The bergamot oil has fresh and elegant smell, is similar to oranges and lemons, has slight flower fragrance, integrates rich smell of fruit fragrance and flower fragrance, and is one of the most commonly used essential oils in perfume. The multifunctional bed can soothe and enhance the vibration, so that the multifunctional bed is the best choice for anxiety, depression and mental stress, has different excitation and excitation functions, and can help people relax.
Preferably, the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 1-4 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil and 1-3 parts of bergamot oil.
Preferably, the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1-2 parts of lemon oil and 1-2 parts of bergamot oil.
In one embodiment provided by the invention, the compound essential oil comprises the following components in parts by volume:
10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 2 parts of lemon oil and 1 part of bergamot oil.
In another embodiment provided by the invention, the compound essential oil comprises the following components in parts by volume:
2 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1 part of lemon oil and 2 parts of bergamot oil.
Preferably, the compound essential oil also comprises one or more of the following components in parts by volume:
0.1-1 part of rosemary oil, 1-5 parts of Happy sage oil, 1-3 parts of frankincense oil, 1-5 parts of grapefruit oil, 1-5 parts of sweet orange oil, 1-5 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemongrass oil.
Rosemary oil mainly contains 2-arrowhead alcohol, is mainly used in essential oil for losing weight, shaping body, enlarging breast and beautifying body, can improve the disorders of language, vision and hearing, enhance attention, treat rheumatalgia, strengthen liver function, reduce blood sugar, is beneficial to the treatment of arteriosclerosis and helps the recovery of vitality of limbs paralyzed. Rosemary oil can activate brain cells, make brain clear, and enhance memory; improving nervous mood, depression and lethargy; can invigorate human vitality, strengthen heart, and has functions of vibration and excitation.
The Happy sage oil can improve the state of nervous tension and panic and malposition, relieve the parasympathetic nerve, make people warm and happy, is suitable for the states of fatigue, depression and sadness, and can obviously enhance the memory.
The fragrance of the mastic oil is warm and pure woody fragrance, and has light fruity fragrance, so that people can breathe slowly, feel relaxed and relaxed, feel stable, have good and mild mood, help relieve the negative emotions of impatience, contusion, sadness and the like, and help meditation.
The grapefruit oil mainly comprises the chemical components of pinene or pinene, sabinene, myrcene, limonene, geraniol, linalool, citronellal, decyl acetate and terpinene or terpinene, can strongly refresh, can relieve stress, dispel depression and restore spirit of people, and is a regulator for seasonal mental disorder.
Sweet orange oil is one of essential oils with tranquilizing effect, and has effects of relaxing nerves, relieving pressure, maintaining physical and mental pleasure, improving vigor, dispelling nervous mood and pressure, and improving insomnia caused by anxiety.
The citrus oil contains d-limonene as main ingredient, and has expectorant, antitussive, gastrointestinal motility promoting, digestive juice secretion promoting, analgesic, cholelithiasis dissolving, antiinflammatory, and antibacterial effects. Meanwhile, the citrus oil also has the effects of tranquilizing central nerves of a human body and relieving stress.
The main components of the white magnolia oil are linalool, linalyl acetate, dihydrolinalool, phenethyl alcohol, eucalyptol, linalool oxide, terpineol, caryophyllene and the like. Fresh and delicate fragrance, sweet and elegant fragrance, and transparent fragrance without long-lasting fragrance. Can calm and relax nerves, and eliminate tension and palpitation.
The main components of the lemongrass oil are citral, myrcene, limonene and the like, so that people can feel fresh, and the lemongrass oil has the effects of stimulating and restoring spirit and is helpful for promoting vibration.
The compound essential oil integrates the effects of various essential oils, coordinates with each other, supplements each other and enhances the curative effect, so that the compound essential oil has the obvious functions of relieving fatigue, refreshing and restoring consciousness and revivifying. The compound essential oil is compounded by pure natural plant essential oil, does not contain artificial additives such as preservative, essence, mineral oil and the like, and has the advantages of pure texture, mild property, safe use and no irritation. The compound essential oil is compounded by a plurality of essential oils, has fragrant and pleasant fragrance, is mild and relaxed, has long fragrance retention time, and is suitable for various crowds.
Preferably, the compound essential oil further comprises the following components in parts by volume:
0.2-1 part of rosemary oil, 2-3 parts of Happy sage oil, 1-2 parts of frankincense oil, 1-4 parts of grapefruit oil, 2-4 parts of sweet orange oil, 2-4 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemongrass oil.
More preferably, the compound essential oil is further added with the following components in parts by volume:
0.2-1 part of rosemary oil, 2-3 parts of Happy sage oil, 1-2 parts of frankincense oil, 1-4 parts of grapefruit oil, 2-4 parts of sweet orange oil, 2-4 parts of citrus oil, 2-3 parts of magnolia alba oil and 1-5 parts of lemongrass oil.
In an embodiment provided by the invention, the compound essential oil comprises the following components in parts by volume:
5 parts of geranium oil, 1 part of cedar oil, 1 part of jasmine oil, 3 parts of lemon oil, 3 parts of bergamot oil, 1 part of rosemary oil, 3 parts of clary sage oil, 2 parts of frankincense oil, 4 parts of grapefruit oil, 4 parts of sweet orange oil, 4 parts of citrus oil, 2 parts of magnolia alba oil and 5 parts of lemongrass oil.
In another embodiment provided by the invention, the compound essential oil comprises the following components in parts by volume:
4 parts of geranium oil, 4 parts of cedar oil, 3 parts of jasmine oil, 2 parts of lemon oil, 2 parts of bergamot oil, 0.2 part of rosemary oil, 2 parts of clary sage oil, 1 part of frankincense oil, 1 part of grapefruit oil, 2 parts of sweet orange oil, 2 parts of citrus oil, 3 parts of magnolia alba oil and 1 part of lemongrass oil.
Preferably, the compound essential oil comprises the following components in parts by volume:
1-10 parts of geranium oil, 1-5 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil, 1-3 parts of bergamot oil, 1-5 parts of sage oil, 1-3 parts of frankincense oil, 1-5 parts of grapefruit oil, 1-5 parts of sweet orange oil, 1-5 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemon grass oil.
Preferably, the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 1-4 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil, 1-3 parts of bergamot oil, 2-3 parts of sage oil, 1-2 parts of frankincense oil, 1-4 parts of grapefruit oil, 2-4 parts of sweet orange oil, 2-4 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemon grass oil.
Preferably, the compound essential oil comprises the following components in parts by volume:
1-10 parts of geranium oil, 1-5 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil, 1-3 parts of bergamot oil and 0.1-1 part of rosemary oil.
Preferably, the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 1-4 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil, 1-3 parts of bergamot oil and 0.2-1 part of rosemary oil.
More preferably, the compound essential oil comprises the following components in parts by volume:
2 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1 part of lemon oil, 2 parts of bergamot oil, 2 parts of Happy sage oil, 1 part of frankincense oil, 2 parts of grapefruit oil, 2 parts of sweet orange oil, 2 parts of citrus oil, 1 part of magnolia alba oil and 2 parts of lemongrass oil;
or 10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 2 parts of lemon oil, 1 part of bergamot oil and 0.5 part of rosemary oil.
The invention also provides application of the compound essential oil in preparing products with the effects of relieving fatigue and refreshing.
The invention also provides a preparation method of the compound essential oil, which is characterized in that the components in the compound essential oil are uniformly mixed according to the parts by volume.
The invention also provides a compound essential oil product, which comprises the compound essential oil and auxiliary materials acceptable in health-care science.
The invention provides compound essential oil, application thereof and a compound essential oil product. The compound essential oil comprises the following components in parts by volume: 1-10 parts of geranium oil, 1-5 parts of cedar oil, 1-3 parts of jasmine oil, 1-3 parts of lemon oil and 1-3 parts of bergamot oil. The invention has the technical effects that:
(1) according to the invention, the stock solution of the pure natural plant essential oil is reasonably compatible, and the scientific proportion ratio is combined, so that the synergistic effect is achieved, and the obtained compound essential oil has a good fatigue relieving effect.
(2) The pure natural plant essential oil is used, does not contain essence, preservative and mineral oil, has the functions of antibiosis and sterilization, and has pure quality, mildness, safety, pleasant aroma and no irritation.
(3) Compounding compound essential oil: by compounding various plant essential oils, the effects of supplementing each other and enhancing the curative effect are achieved, and the comfort, safety and effectiveness of the human body are improved.
(4) The flavor level is rich: when in use, the aroma can change gradually along with the prolonging of time, and different experiences and feelings can be brought to people.
(5) The compound essential oil has good effects of relieving fatigue and revivifying, has fragrant and non-pungent taste and high crowd acceptance and can be directly applied to skin.
Detailed Description
The invention discloses compound essential oil, application thereof and a compound essential oil product, and a person skilled in the art can appropriately improve process parameters by referring to the content. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The compound essential oil, the application thereof and the raw materials or auxiliary materials used in the compound essential oil product can all be purchased from the market.
The invention is further illustrated by the following examples:
examples 1 to 6
The compound essential oil of the embodiment comprises the components in parts by volume as shown in the following table.
TABLE 1 examples 1-6 Compound essential oil formulations
Figure BDA0001906498880000071
Figure BDA0001906498880000081
Comparative examples 1 to 5:
table 2 comparative examples 1-5 formula of compound essential oil
Components Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5
Geranium oil 0 2 15 0 0
Cedar oil 2 2 2 0 0
Jasmine oil 0 1 1 0 0
Lemon oil 2 1 2 0 0
Bergamot oil 1 0 1 0 0
Rosemary oil 0 0 0 0 0.5
Happy sage oil 0 0 0 2 2
Mastic oil 0 0 0 1 1
Grapefruit oil 0 0 0 2 2
Sweet orange oil 0 0 0 2 2
Citrus oil 0 0 0 2 2
White magnolia oil 0 0 0 1 1
Lemongrass oil 0 0 0 2 2
Test example 1
To further demonstrate the advantages of the present invention, the present invention provides the effect verification data of examples 1-6 and comparative examples 1-5.
(I) verification experiment of the compound essential oil of examples 1-6 and comparative examples 1-5 on the anti-fatigue capability of mice.
(1) Laboratory animal
Selecting SPF-grade Kunming mice as test objects, wherein the weight of each mouse is 18-20 g. After adaptive feeding for 7 days, the mice are randomly divided into a blank control group, 6 example groups and 5 comparative example groups, the mice are respectively put into a fresh-keeping box for smelling fragrance, and a small heating atomization device is arranged in the fresh-keeping box.
(2) Experimental methods
1 group is blank control group, heating and atomizing to inhale distilled water, the dosage is 100 μ L each time, the inhaling time is 30min each time, and the time is 30d continuously;
2-7 groups are examples 1-6 groups, and the compound essential oil of examples 1-6 is heated, atomized and inhaled, wherein the dosage is 100 mu L each time, the inhalation time is 30min each time, and the continuous time is 30 days;
8-12 groups are comparative examples 1-5, and the compound essential oil of comparative examples 1-5 is inhaled by heating and atomizing, wherein the dosage is 100 mu L each time, the inhalation time is 30min each time, and the continuous time is 30 days.
The experiment is carried out 30min after smelling fragrance on day 30, and the results of the mouse weight-bearing swimming time, serum urea nitrogen, liver glycogen and blood lactic acid are observed.
Mouse weight bearing swimming time: and after smelling fragrance for 30min for the last time, putting the tail root of the mouse loaded with 5% weight of lead skin into a swimming box for swimming, wherein the water depth is 30cm, the water temperature is 25 +/-1 ℃, and recording the time from swimming to death of the mouse, namely the time for the mouse to bear the weight for swimming.
Serum urea nitrogen: after smelling fragrance for the last time for 30min, the mice swim in water at the temperature of 30 +/-1 ℃ for 90min without load, after resting for 60min, pull out the eyeball to collect whole blood, and determine the serum urea nitrogen by a diacetyl-oxime method.
Hepatic glycogen: after smelling fragrance for 30min for the last time, the mice are placed in water with the temperature of 30 +/-1 ℃ for swimming for 90min without load, then the mice are killed, the liver is rinsed by physiological saline and then is sucked dry by filter paper, and the content of hepatic glycogen is measured by adopting an anthrone method.
Blood lactic acid: collecting blood 30min after last fragrance smelling, then swimming 4% lead skin in 30 + -1 deg.C water for 10min, collecting blood immediately after swimming, taking blood after resting for 20min, and measuring blood lactic acid content with lactic acid meter.
(3) Data processing
The measured data is expressed by mean plus or minus standard deviation, and the data is processed by adopting a one-factor variance analysis method. P < 0.05 indicates statistical significance.
(4) Results of the experiment
TABLE 3 Effect of different groups of Compound essential oils on the weight bearing swimming time of mice (Water temperature 25 deg.C)
Figure BDA0001906498880000091
Figure BDA0001906498880000101
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f, g, h, i, j, k) indicates that the comparison between the different groups of the examples and the comparative examples is carried out, and the letters indicate that the significant difference is marked, and P is less than 0.05.
TABLE 4 Effect of different groups of compound essential oils on serum urea nitrogen after mouse exercise
Group of Examples/only Serum urea nitrogen (mg/dL)
Blank control group 10 67.0±6.7*a
EXAMPLE 1 group 10 37.7±6.5*ef
EXAMPLE 2 group 10 41.2±7.3*de
EXAMPLE 3 group 10 27.1±6.9*f
EXAMPLE 4 group 10 31.1±9.0*ef
EXAMPLE 5 group 10 33.4±11.4*ef
EXAMPLE 6 group 10 35.9±9.2*ef
Comparative example 1 group 10 52.5±7.1*bc
Comparative example 2 group 10 49.7±7.6*cd
Comparative example 3 group 10 47.8±11.6*cd
Comparative example 4 group 10 60.5±9.3*ab
Comparative example 5 group 10 55.1±9.0*bc
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f) indicates that the comparison is carried out between different groups of the examples and the comparative examples, and different letters indicate that the difference is significant, and P is less than 0.05.
TABLE 5 influence of different groups of compound essential oils on the glycogen content of mouse liver
Group of Examples/only Hepatic glycogen (mg/100g liver)
Blank control group 10 353.2±6.5*l
EXAMPLE 1 group 10 601.0±17.6*e
EXAMPLE 2 group 10 552.5±15.1*f
EXAMPLE 3 group 10 804.8±10.5*a
EXAMPLE 4 group 10 751.7±11.9*b
EXAMPLE 5 group 10 702.8±15.0*c
EXAMPLE 6 group 10 652.5±15.1*d
Comparative example 1 group 10 441.0±25.5*i
Comparative example 2 group 10 474.5±19.6*h
Comparative example 3 group 10 504.5±19.6*g
Comparative example 4 group 10 388.0±22.6*k
Comparative example 5 group 10 416.0±21.8*j
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f, g, h, i, j, k, l) indicates that the comparison between the different groups of the examples and the comparative examples is carried out, and the letters indicate that the significant difference is marked, and P is less than 0.05.
TABLE 6 influence of different groups of compound essential oils on the number of blood lactic acid in mice before and after exercise
Figure BDA0001906498880000111
Figure BDA0001906498880000121
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f, g) indicates that the comparison between the examples and the comparative examples is carried out, and the letters indicate that the difference is significant, and P is less than 0.05.
As can be seen from the above tests, the weight-bearing swimming time and the hepatic glycogen content of the mice are increased and have significant differences (P < 0.05) in the groups of examples 1 to 6 and the groups of comparative examples 1 to 5 compared with the blank control group; the serum urea nitrogen and the blood lactic acid values before and after exercise are all reduced, and the significant difference is achieved (P is less than 0.05).
The experimental result shows that the essential oils of examples 1-6 and comparative examples 1-5 have certain fatigue relieving effect. The results of comparison between the groups of examples 1-6 and the groups of comparative examples 1-5 show that the weight-bearing swimming time and the liver glycogen content of the groups of examples 1-6 are obviously greater than those of the groups of comparative examples 1-5, the serum urea nitrogen and the blood lactic acid values before and after exercise are all obviously less than those of the groups of comparative examples 1-5, and the optimal effect is the group of example 3. The results suggest that the combination of geranium oil, cedar oil, jasmine oil, lemon oil and bergamot oil in a certain proportion can exert a synergistic effect and obtain a better anti-fatigue effect, and one or more of rosemary oil, sage oil, frankincense oil, grapefruit oil, sweet orange oil, citrus oil, magnolia alba oil and lemongrass oil are further added, so that the effect of the composition can be further improved.
(II) investigation of the Compound essential oil fragrance acceptability in examples 1-6 and comparative examples 1-5
Please use 50 experienced professionals to form an evaluation group to evaluate the compound essential oil fragrance described in examples 1-6 and comparative examples 1-5, and the evaluation results are as follows:
TABLE 7 people's receptivity to different essential oil fragrances
Group of Satisfaction In general Is not satisfied with
EXAMPLE 1 group 42 5 3
EXAMPLE 2 group 41 6 3
EXAMPLE 3 group 46 3 1
EXAMPLE 4 group 45 4 1
EXAMPLE 5 group 44 5 1
EXAMPLE 6 group 44 4 2
Comparative example 1 group 39 7 4
Comparative example 2 group 35 10 5
Comparative example 3 group 37 8 5
Comparative example 4 group 33 11 6
Comparative example 5 group 36 8 6
TABLE 8 ratio of acceptance of different essential oil aromas by the population
Group of Satisfaction In general Is not satisfied with
EXAMPLE 1 group 84％ 10％ 6％
EXAMPLE 2 group 82％ 12％ 6％
EXAMPLE 3 group 92％ 6％ 2％
EXAMPLE 4 group 90％ 8％ 2％
EXAMPLE 5 group 88％ 10％ 2％
EXAMPLE 6 group 88％ 8％ 4％
Comparative example 1 group 78％ 14％ 8％
Comparative example 2 group 70％ 20％ 10％
Comparative example 3 group 74％ 16％ 10％
Comparative example 4 group 66％ 22％ 12％
Comparative example 5 group 72％ 16％ 12％
The above test results show the acceptance of different combinations of essential oil flavors by the human population, and as can be seen from the dissatisfaction, the examples are all less unsatisfactory than the comparative examples, and thus it can be seen that the flavor acceptance of each example is higher than the comparative examples, with the satisfaction being the highest as in example 3.
Test example 2
To further demonstrate the advantages of the compound essential oil of the present invention over the single essential oil, the present invention provides the verification experiment of the anti-fatigue capability of mice by using the compound essential oil of the present invention, namely, geranium oil, cedar oil, jasmine oil, lemon oil and bergamot oil in example 1.
(1) Laboratory animal
Selecting SPF-grade Kunming mice as test objects, wherein the weight of each mouse is 18-20 g. After adaptive feeding for 7 days, the mice are randomly divided into 1 embodiment group and 5 single essential oil groups, the mice are respectively put into a preservation box for smelling fragrance, and a small heating and atomizing device is arranged in the preservation box.
(2) Experimental methods
Example 1, heating and atomizing to inhale the compound essential oil of example 1, wherein the dosage is 100 mu L each time, the inhaling time is 30min each time, and the time lasts for 30 days;
heating and atomizing single essential oil group to inhale the single essential oil, wherein the dosage is 100 mu L each time, and the inhaling time is 30min each time and 30d continuously.
The experiment is carried out 30min after smelling fragrance on day 30, and the results of the mouse weight-bearing swimming time, serum urea nitrogen, liver glycogen and blood lactic acid are observed.
Mouse weight bearing swimming time: and after smelling fragrance for 30min for the last time, putting the tail root of the mouse loaded with 5% weight of lead skin into a swimming box for swimming, wherein the water depth is 30cm, the water temperature is 25 +/-1 ℃, and recording the time from swimming to death of the mouse, namely the time for the mouse to bear the weight for swimming.
Serum urea nitrogen: after smelling fragrance for the last time for 30min, the mice swim in water at the temperature of 30 +/-1 ℃ for 90min without load, after resting for 60min, pull out the eyeball to collect whole blood, and determine the serum urea nitrogen by a diacetyl-oxime method.
Hepatic glycogen: after smelling fragrance for 30min for the last time, the mice are placed in water with the temperature of 30 +/-1 ℃ for swimming for 90min without load, then the mice are killed, the liver is rinsed by physiological saline and then is sucked dry by filter paper, and the content of hepatic glycogen is measured by adopting an anthrone method.
Blood lactic acid: collecting blood 30min after last fragrance smelling, then swimming 4% lead skin in 30 + -1 deg.C water for 10min, collecting blood immediately after swimming, taking blood after resting for 20min, and measuring blood lactic acid content with lactic acid meter.
(3) Data processing
The measured data is expressed by mean plus or minus standard deviation, and the data is processed by adopting a one-factor variance analysis method. P < 0.05 indicates statistical significance.
(4) Results of the experiment
TABLE 9 Effect of Compound essential oil or Single essential oil on weight bearing swimming time of mice (Water temperature 25 deg.C)
Group of Examples/only Swimming time/S
EXAMPLE 1 group 10 552.1±8.2*a
Geranium oil group 10 402.3±6.3*c
Cedar oil group 10 386±7.9*e
Jasmine oil 10 396±10.1*d
Lemon oil 10 378±8.5*f
Bergamot oil group 10 409±9.4*b
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f) indicates that the comparison is carried out between different groups of the examples and the comparative examples, and different letters indicate that the difference is significant, and P is less than 0.05.
TABLE 10 Effect of Compound essential oil or Single essential oil on serum Urea Nitrogen after exercise in mice
Group of Examples/only Serum urea nitrogen (mg/dL)
EXAMPLE 1 group 10 37.7±6.5*d
Geranium oil group 10 63.2±5.3*abc
Cedar oil group 10 64.9±7.9*ab
Jasmine oil 10 64.1±8.4*abc
Lemon oil 10 65.3±7.6*ab
Bergamot oil group 10 61.5±5.1*bc
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the letters (a, b, c, d) in the same row indicate that the comparison is carried out between different groups of the examples and the comparative examples, and the letters indicate that the difference is significant, and P is less than 0.05.
TABLE 11 Effect of Compound essential oil or Single essential oil on liver glycogen content in mice
Group of Examples/only Hepatic glycogen (mg/100g liver)
EXAMPLE 1 group 10 601.0±17.6*a
Geranium oil group 10 374±21.3*cd
Cedar oil group 10 361±27.6*de
Jasmine oil 10 368±18.9*de
Lemon oil 10 354±15.4*e
Bergamot oil group 10 385±26.7*bc
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e) indicates that the comparison is carried out between different groups of the examples and the comparative examples, and different letters indicate that the difference is significant, and P is less than 0.05.
TABLE 12 Effect of Compound essential oil or Single essential oil on blood lactic acid values before and after exercise in mice
Figure BDA0001906498880000161
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e) indicates that the comparison is carried out between different groups of the examples and the comparative examples, and different letters indicate that the difference is significant, and P is less than 0.05.
Experimental results show that the compound essential oil and the single essential oil in the embodiment 1 have certain fatigue relieving effect. The results of the group comparison between the group of example 1 and the single essential oil group show that the swimming time and liver glycogen content of the group of example 1 are obviously greater than those of the single essential oil group, and the serum urea nitrogen and the blood lactic acid value before and after exercise are obviously less than those of the single essential oil group. The result indicates that the combination of the geranium oil, the cedar oil, the jasmine oil, the lemon oil and the bergamot oil according to a certain proportion can play a synergistic effect and obtain a better anti-fatigue effect.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (8)

1. The compound essential oil with the effects of relieving fatigue and refreshing brain is characterized by comprising the following components in parts by volume:
2-10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1-2 parts of lemon oil and 1-2 parts of bergamot oil.
2. The compound essential oil with the effects of relieving fatigue and refreshing, which is characterized by comprising the compound essential oil of claim 1 and one or more of the following components in parts by volume:
0.1-1 part of rosemary oil, 1-5 parts of Happy sage oil, 1-3 parts of frankincense oil, 1-5 parts of grapefruit oil, 1-5 parts of sweet orange oil, 1-5 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemongrass oil.
3. The compound essential oil according to claim 2, wherein the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1-2 parts of lemon oil, 1-2 parts of bergamot oil, 1-5 parts of clary sage oil, 1-3 parts of frankincense oil, 1-5 parts of grapefruit oil, 1-5 parts of sweet orange oil, 1-5 parts of citrus oil, 1-3 parts of magnolia alba oil and 1-5 parts of lemongrass oil.
4. The compound essential oil according to claim 2, wherein the compound essential oil comprises the following components in parts by volume:
2-10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1-2 parts of lemon oil, 1-2 parts of bergamot oil and 0.1-1 part of rosemary oil.
5. The compound essential oil according to claim 2, wherein the compound essential oil comprises the following components in parts by volume:
2 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 1 part of lemon oil, 2 parts of bergamot oil, 2 parts of Happy sage oil, 1 part of frankincense oil, 2 parts of grapefruit oil, 2 parts of sweet orange oil, 2 parts of citrus oil, 1 part of magnolia alba oil and 2 parts of lemongrass oil;
or 10 parts of geranium oil, 2 parts of cedar oil, 1 part of jasmine oil, 2 parts of lemon oil, 1 part of bergamot oil and 0.5 part of rosemary oil.
6. Use of the compound essential oil of any one of claims 1 to 5 in the preparation of a product with the effects of relieving fatigue and refreshing.
7. The preparation method of the compound essential oil as claimed in any one of claims 1 to 5, characterized in that the components of the compound essential oil are uniformly mixed according to the volume parts.
8. A compound essential oil product, which is characterized by comprising the compound essential oil of any one of claims 1 to 5 and auxiliary materials acceptable in health care science.
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