CN108635441A - Compound essential oil composition, its application and the product for improving sleep - Google Patents
Compound essential oil composition, its application and the product for improving sleep Download PDFInfo
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Abstract
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：Bitter orange flower oil 1~2；Rome oil of chamomile 1~2；Pelargonium oil 1~5；Lemon oil 1~5.The present invention by the stoste of bitter orange flower oil, Rome oil of chamomile, pelargonium oil and lemon oil these pure natural essential oils by carrying out reasonably compatibility, and combine specific ratio, so that the compound essential oil of gained has the effect of that good collaboration calms the nerves, improves sleep, and fragrance crowd acceptance is high.In addition, the compound essential oil of the present invention without artificial synthetic essence, do not add preservative, without mineral grease, without the chemical composition for causing allergy, ingredient safety is not easy allergy.
Description
Technical field
The present invention relates to health protection with Chinese medicine technical field, more particularly, to a kind of compound essential oil composition, its application and
Improve the product of sleep.
Background technology
Insomnia is a kind of common sleep disturbance phenomenon, typically refer to patient to sleeping time (and/or) quality is unsatisfactory for
And influence a kind of subjective experience of social function in the daytime.The clinical manifestation of insomniac mainly has following aspect：
1. the obstacle of sleep procedure：Difficulty falling asleep, sleep quality decline and sleeping time is reduced.
2. cognition dysfunction between day：Memory function declines, attention function declines, plan function reduction, so as to cause white
It is sleepy, and ability to work declines, and daytime sleepiness phenomenon is susceptible to when being stopped.
3. cerebral limbic system and surrounding vegetative nerve functional disturbance：Cardiovascular system shows as uncomfortable in chest, palpitaition, blood
Press unstable, peripheral vessels contraction extension obstacle；Digestive system manifestation is that constipation or diarrhea, stomach are bored swollen；Kinematic system shows
For neck and shoulder part muscular tone, headache and pain in the back.Emotion control decreased capacity is easily offended or unhappy；Male is susceptible to
Often there are the performances such as sexual function attenuating in impotence, women.
4. other systems symptom：It is susceptible to weight attenuating in a short time, immune function lowers and endocrine dysfunction.
With the development of the social economy, the increase of people's life stress, the trend risen is presented in the incidence of insomnia, according to me
State's six metropolitan investigation display：There is insomnia in 57% adult.Chronic insomnia can influence the normal life of patient, work
Make, severe patient can also influence physical and mental health.The drug of common treatment sleep disturbance has barbiturates, benzene phenodiazine at presentIt is class, non-
Typical benzene phenodiazineClass etc., but not only side effect is big for this kind of drug, and long-term use is also possible to that patient can be allowed to generate pharmacological dependence.Cause
This, it is particularly important to find pure natural, safe without toxic side effect the product for improving sleep quality.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of compound essential oil composition, the present invention provides
Compound essential oil composition have the effect of it is good calm the nerves, improve sleep, and fragrance crowd acceptance is high.
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：
Preferably, the compound essential oil composition includes the component of following volume parts：
Preferably, the compound essential oil composition further includes the component of any one or a few following volume parts：
Preferably, the compound essential oil composition further includes the component of any one or a few following volume parts：
Preferably, the compound essential oil composition includes the component of following volume parts：
Preferably, the compound essential oil composition includes the component of following volume parts：
Bitter orange flower oil 2；Rome oil of chamomile 2；Pelargonium oil 2；Lemon oil 2；Flos micheliae Albae oil 4；Evening primrose oil 10；Spearmint
Oil 1.0；Clary Sage oil 1.0；Lavender oil 2；Tangerine oil 2；Frankincense oil 2.
Preferably, the compound essential oil composition includes the component of following volume parts：
Bitter orange flower oil 1；Rome oil of chamomile 1；Pelargonium oil 2；Lemon oil 2；Lavender oil 3；Attar of rose 2；Thyme linaloe oil
1.0；Oil of grapefruit 2；Bergamot oil 2；Orange oil 1；Clove bud oil 2.
Preferably, the compound essential oil composition includes the component of following volume parts：
Bigarabe spends 2；Rome oil of chamomile 2；Pelargonium oil 5；Lemon oil 5；Flos micheliae Albae oil 6；Evening primrose oil 15；Oleum menthae viridis
1.5；Clary Sage oil 1.5；Lavender oil 4；Tangerine oil 6；Frankincense oil 3；Attar of rose 5；Thyme linaloe oil 1.5；Oil of grapefruit 5；
Bergamot oil 5；Orange oil 5；Clove bud oil 3.
The present invention provides the compositions described in above-mentioned technical proposal any one in the product for preparing sleep of calming the nerves, improve
In application.
The present invention provides a kind of products calmed the nerves, improve sleep, including the group described in above-mentioned technical proposal any one
Close object.
Compared with prior art, the present invention provides a kind of compound essential oil composition, include the component of following volume parts：
Bitter orange flower oil 1~2；Rome oil of chamomile 1~2；Pelargonium oil 1~5；Lemon oil 1~5.The present invention is by by bitter orange flower oil, sieve
The stoste of these pure natural essential oils of horse oil of chamomile, pelargonium oil and lemon oil carries out reasonably compatibility, and combines and specifically match
Compare ratio so that the compound essential oil of gained has the effect of that good collaboration calms the nerves, improves sleep, and fragrance crowd's acceptance
It is high.In addition, the compound essential oil of the present invention without artificial synthetic essence, do not add preservative, without mineral grease, without causing
Quick chemical composition, ingredient safety, is not easy allergy.
Specific implementation mode
The present invention provides a kind of compound essential oil composition, the product of its application and sleep of calming the nerves, improve, this field skills
Art personnel can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it should be pointed out that all similar replacements and
Change apparent to those skilled in the art, they shall fall within the protection scope of the present invention.The method of the present invention
And application is described by preferred embodiment, related personnel can obviously not depart from the content of present invention, spirit and model
Enclose it is interior to methods herein and application be modified or suitably change and combine, to realize and apply the technology of the present invention.
The present invention provides the components that a kind of compound essential oil composition includes following volume parts：
Compound essential oil composition provided by the invention includes the bitter orange flower oil of 1~2 parts by volume；Preferably include 2 parts by volume
Bitter orange flower oil.
Bitter orange flower oil is by the fresh flower of rutaceae bigarabe (Citrus auranthium) and sweet orange (C sinensis)
It is obtained through steam distillation.Yield 0.07%~0.15%.Mainly originate in France, Tunisia, Italy, Algeria etc.
Also there is a small amount of production in state, China.
Compound essential oil composition provided by the invention includes the Rome oil of chamomile of 1~2 parts by volume；Preferably include 2 volumes
The Rome oil of chamomile of part.
Rome chamomile is perennial plant, and original is distributed in southern Europe to West Europe, and there are plantation in many countries now.It is spent
The heart is yellow, and petal is white, can highly grow to 60 centimetres.Yellow is presented in distillable essential oil color, with point sweet tea sweet tea
Draft taste.
Compound essential oil composition provided by the invention includes the pelargonium oil of 1~5 parts by volume；Preferably include 2~4 parts by volume
Pelargonium oil；More preferably include the pelargonium oil of 2~3 parts by volume.
About 60 centimeters of fish pelargonium, flower are pink, lobate front end in pointed and with sawtooth, essential oil from distillation floral leaf,
Taste is slightly like rose.
Compound essential oil composition provided by the invention includes the lemon oil of 1~5 parts by volume；Preferably include 2~4 parts by volume
Lemon oil；More preferably include the lemon oil of 2~3 parts by volume.
Lemon oil is the fresh peel by lemon through a kind of essential oil obtained by squeezing, is yellow liquid.
The present invention is by by the original of bitter orange flower oil, Rome oil of chamomile, pelargonium oil and lemon oil these pure natural essential oils
Liquid carries out reasonably compatibility, and combines specific ratio so that there is the compound essential oil of gained good collaboration improvement to sleep
Dormancy effect, and fragrance crowd acceptance is high.In addition, the present invention compound essential oil without artificial synthetic essence, do not add preservative,
Without mineral grease, without the chemical composition for causing allergy, ingredient safety is not easy allergy.
In some embodiments, the compound essential oil composition includes the component of following volume parts：
In the present invention, the essential oil composition preferably further includes the component of any one or a few following volume parts：
Flos micheliae Albae oil 0~6；Evening primrose oil 0~15；Oleum menthae viridis 0~1.5；Clary Sage oil 0~1.5；Lavender oil
0~4；Tangerine oil 0~6；Frankincense oil 0~3；Attar of rose 0~5；Thyme linaloe oil 0~1.5；Oil of grapefruit 0~5；Bergamot oil 0~
5；Orange oil 0~5；Clove bud oil 0~3.
It more preferably further include the component of following arbitrary seven kinds or seven kinds or more volume parts：
Flos micheliae Albae oil 0~6；Evening primrose oil 0~15；Oleum menthae viridis 0~1.5；Clary Sage oil 0~1.5；Lavender oil
0~4；Tangerine oil 0~6；Frankincense oil 0~3；Attar of rose 0~5；Thyme linaloe oil 0~1.5；Oil of grapefruit 0~5；Bergamot oil 0~
5；Orange oil 0~5；Clove bud oil 0~3.
Wherein, the extraction of Flos micheliae Albae oil eliminates tension, antianxiety, anti-melancholy and other effects in Flos micheliae Albae flower, tool.Flos micheliae Albae
(scientific name：Michelia alba DC.), it is to open kind also known as lily magnolia, yulan of white flowers etc. in yulan magnolia, is lily magnolia Como
The deciduous tree of Cymbidium, flower is pure white very large, and for the fragrance of a flower like orchid, petal is edible or produces lily magnolia flower concrete.White jade of the present invention
Blue oil is preferably 0~4 parts by volume.
Evening primrose oil is to pass through steam distillation, extrusion, cold soaking in the flower from oenothera biennis, leaf, stem, root or fruit
Method or solvent extraction method refine the volatile flavor of extraction, main component have r- linolenic acids, magnesium, zinc, copper, vitamin C,
Vitamin E, vitamin B6, vitamin B5Deng having the function of multinomial treatment.Evening primrose oil of the present invention is preferably 0~10 volume
Part.
The blade crape of spearmint and it is sharp, flower be purple, 90 centimeters of height can be grown to.The extraction position of oleum menthae viridis：It blooms
Top, leaf；Extracting process：Distillation.Oleum menthae viridis of the present invention is preferably 0~1 parts by volume.
Salvia japonica, English name：CLARY SAGE.Draft small shrub plant, leaf is very special, is pale purple green,
Flower is blue, belongs to draft shrub type, averagely 50~70 centimeters of height, the main place of production is the Balkan Peninsula, and essential oil is distilled from it
Leaf and flower are in chartreuse, the fragrance with some sweet tastes and fennel, camphor.Clary Sage oil of the present invention is preferably
For 0~1 parts by volume.
Lavender is Labiatae lavender platymiscium.Lavender is refined by lavender, can it is clearing heat and detoxicating,
Cleaning skin, control oil, freckle removing and whitening, the tender skin of anti-wrinkle, eye haustra -dsipelling livid ring around eye, may additionally facilitate regeneration of damaged tissue recovery etc.
Skin-protecting function.Lavender also has sedation effect to heart, can reduce hypertension, pacify palpitaition, helpful for having a sleepless night.
Lavender of the present invention is preferably 0~3 parts by volume.
Containing abundant essential oil, about the 0.5%~2% of pericarp fresh weight in the oil vacuole of orange peel.The master of citrus essential oil
It is (R)-4-isopropenyl-1-methyl-1-cyclohexene (d-Limonene) to want ingredient.Tangerine oil of the present invention is preferably 0~2 parts by volume.
Frankincense is Burseraceae frankincense Pterostyrax, is a kind of short and small arbor.It is main originate in Somalia, Yemen, Ethiopia,
The U.S., Britain, France.The resin secreted with steam distillation Boswellia carterii, can obtain frankincense oil, be colourless to weak yellow liquid, phase
To density 0.865~0.917, refractive index 1.469~1.483.Frankincense oil of the present invention is preferably 0~2 parts by volume.
Attar of rose is that fresh rose is made through steam distillation.Oil yield is generally 0.02%~0.04%.Rose
Kind it is very more, but can be used to produce meet fragrance requirement mainly have wrinkle leaf rose, big horse color rose, Rosa centifolia and ink
Red Chinese rose.Fresh flower picking after should in 1h working process.Attar of rose is light yellow to yellow liquid.Attar of rose of the present invention is excellent
It is selected as 0~2 parts by volume.
Thyme linaloe oil is to enter the aerial part at florescence by labiate thyme (Thymus vulgaris L.) to pass through
Steam distillation obtains.Have herbal that is refrigerant, doing coke, has the faint scents such as linalool, terpinene concurrently.Principal component is Thymol
(30%~70%), carvacrol (2%~15%).Thyme linaloe oil of the present invention is preferably 0~1 parts by volume.
Grape fruit originates from Asia, it is the seeds of artificial growth, and early stage European brings when decoration, arrangement garden use,
It was about found on the Caribbean island in Latin America Barbados archipelago in 1750, just starts slowly to be commercialized kind later
It plants, is mainly planted in the U.S., Brazil and Israel.Grape fruit fruit is picked from a kind of tree that blade is smooth, and tree is high
10m, white flowers, fruit are huge, faint yellow.Essential oil gland is embedded in pericarp depths, can only produce a small amount of essential oil.Grape fruit is cool in nature, taste
Sweet acid has heat-clearing, the benefits of quenching the thirst, and obtained by oil of grapefruit provided by the invention is squeezed by pericarp, smell is pure and fresh, fragrant and sweet, has
The fruit flavor of citrus.Oil of grapefruit of the present invention is preferably 0~2 parts by volume.
Bergamot oil originates in India from a kind of pericarp of bigarabe tree, such fruit, later China and Italy all
There is production.The breed difference to grow according to the place of production in efficiency, also some differences on taste and ingredient, in the international market really
Bergamot yield is few, Italian bergamot, is that the good mandarin orange yield of shellfish is more actually, the camphor tree of virtue containing acetic acid in ingredient
Fat, limonene, terpinol etc.；The bergamot of China, with slightly sweet in taste sweet tea, nerol, lemon brain, lemon are contained in the inside
Aldehyde, lemon alcohol and note alkenes etc..The medication of the disease by it in terms of being classified as respiratory tract very early, foundation in the ancient books and records of Chinese medicine
《The rigid mesh of book on Chinese herbal medicine》Record：Bergamot taste slightly bitter, acid, temperature, enter liver, spleen, stomach, lung channel, have dispersing stagnated hepatoqi, eliminating dampness and eliminating phlegm do
With can be used for stagnation of liver-QI and stomach-QI, chest side of body flatulence.It is the bactericidal effect having because of itself that bergamot is employed for virtue earliest, which to be treated,
Its effect is no less than lavender, can fight indoor dirt and walk haltingly, therefore is usually used in the alleviation of allergic rhinitis and children's asthma, indoors
Aroma diffusing can not only allow people to feel relief happy, or even have purification air, the effect of the propagation of pre- anti-virus；It is pressed for skin
It rubs, it is helpful for Oilys such as acne, the smegma of oily skin can be balanced.Bergamot oil of the present invention
Preferably 0~2 parts by volume.
Orange oil is obtained by rutaceae sweet orange fresh fruit cold grinding or by fresh fruit skin cold press, and yield 3.5%~
3.7%：The broken pericarp of disintegrating slag and collection that sieving when cold grinding, cold press is gone out is extracted using correct method for sorting, cold press pericarp
Yield 0.8%~1.0%, distilled oil yield 0.4%~0.7%.Orange oil of the present invention is preferably 0~1 parts by volume.
Clove bud oil is the dry flower of plant clove of myrtaceae through the volatile oil of distillation gained.Warm stomach, warm kidney.It is main
Control swollen stomach cold pain, hiccup, vomiting and diarrhoea, numbness pain, colic, halitosis, toothache.Clove bud oil of the present invention is preferably 0~2 volume
Part.
According to the present invention, the compound essential oil composition preferably further includes the group of any one or a few following volume parts
Point：
Flos micheliae Albae oil 2~6；Evening primrose oil 5~15；Oleum menthae viridis 0.5~1.5；Clary Sage oil 0.5~1.5；Smoke clothing
Careless oil 1~4；Tangerine oil 2~6；Frankincense oil 1~3；Attar of rose 1~5；Thyme linaloe oil 0.5~1.5；Oil of grapefruit 1~5；Fingered citron
Mandarin orange oil 1~5；Orange oil 1~5；Clove bud oil 1~3.
In a portion embodiment of the present invention, the compound essential oil composition includes the component of following volume parts：
Bitter orange flower oil 1~2；Rome oil of chamomile 1~2；Pelargonium oil 2~3；Lemon oil 2~3；Flos micheliae Albae oil 0~4；Month
See careless oil 0~10；Oleum menthae viridis 0~1.0；Clary Sage oil 0~1.0；Lavender oil 0~3；Tangerine oil 0~2；Frankincense oil 0
~2；Attar of rose 0~2；Thyme linaloe oil 0~1.0；Oil of grapefruit 0~2；Bergamot oil 0~2；Orange oil 0~1；Clove bud oil
0~2.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Bitter orange flower oil 2；Rome oil of chamomile 2；Pelargonium oil 2；Lemon oil 2；Flos micheliae Albae oil 4；Evening primrose oil 10；Spearmint
Oil 1.0；Clary Sage oil 1.0；Lavender oil 2；Tangerine oil 2；Frankincense oil 2.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Bitter orange flower oil 1；Rome oil of chamomile 1；Pelargonium oil 2；Lemon oil 2；Lavender oil 3；Attar of rose 2；Thyme linaloe oil
1.0；Oil of grapefruit 2；Bergamot oil 2；Orange oil 1；Clove bud oil 2.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Bigarabe spends 2；Rome oil of chamomile 2；Pelargonium oil 5；Lemon oil 5；Flos micheliae Albae oil 6；Evening primrose oil 15；Oleum menthae viridis
1.5；Clary Sage oil 1.5；Lavender oil 4；Tangerine oil 6；Frankincense oil 3；Attar of rose 5；Thyme linaloe oil 1.5；Oil of grapefruit 5；
Bergamot oil 5；Orange oil 5；Clove bud oil 3.
The present invention is for above-mentioned bitter orange flower oil, Rome oil of chamomile, pelargonium oil, lemon oil, Flos micheliae Albae oil, oenothera biennis
Oil, oleum menthae viridis, Clary Sage oil, lavender oil, tangerine oil, frankincense oil, attar of rose, thyme linaloe oil, oil of grapefruit, fingered citron
The source of mandarin orange oil, orange oil and clove bud oil is commercially available without limiting.
The discovery of the present inventor's creativeness, in the bitter orange flower oil, Rome oil of chamomile, fish pelargonium of the present invention of specific proportioning
Oil, cooperation Flos micheliae Albae oil on the basis of lemon oil, evening primrose oil, oleum menthae viridis, Clary Sage oil, lavender oil, tangerine oil,
Seven kinds or seven kinds in frankincense oil, attar of rose, thyme linaloe oil, oil of grapefruit, bergamot oil, orange oil and clove bud oil with
On；Above-mentioned seven kinds or more ten kinds or less are preferably selected with bitter orange flower oil, Rome oil of chamomile, pelargonium oil, lemon oil to be matched
5 collaborations, the compound essential oil being finally prepared, which has the effect of significantly cooperateing with, calms the nerves, improves sleep, and fragrance crowd receives
Degree is high.
In addition, the compound essential oil of the present invention is also equipped with following features：A is free of essence：Use the stoste of pure natural essential oil, generation
For artificial synthetic essence.Therefore matter is pure, mild, safety, fragrance is pleasant, does not stimulate, and has the effect of aromatotherapy.B does not add anti-
Rotten agent：Natural essential oil has the function of antibacterial, sterilization mostly, without adding preservative.C is free of mineral grease：It entirely uses natural
Plants essential oil.D is free of the chemical composition for causing allergy：Pure natural essential oil is entirely free of artificial essence, lanolin, alcohol, chemistry
Property sun-screening agent, pigment etc. can cause the ingredient of allergy, and to adding the raw material used each time, all it was proved that, to people
Body not will produce allergy.E flavor changes：Fragrance gradually changes as time went on, and different fragrance can be brought to people to differ
The experience and impression of sample allow people to generate different mood.F improves air quality：Natural essential oil mostly with antibacterial, sterilization work
With can improve air quality, air is made to keep fragrant freshness.G compound essential oils are safe in folk prescription essential oil：Compound essential oil
Significantly reduce in each folk prescription essential oil has certain toxicity and excitatory chemical composition such as phenols and aldoketones to human body, improves
Terpenes and alcohols property safe to the human body are high, no irritating chemical composition of sensitivity.
The preparation method of the present invention is that bitter orange flower oil, Rome oil of chamomile, pelargonium oil, lemon oil is straight according to parts by volume
Mixing is connect, is method well known to those skilled in the art, the present invention is to this without limiting.
Or by bitter orange flower oil, Rome oil of chamomile, pelargonium oil, lemon oil cooperation Flos micheliae Albae oil, evening primrose oil, green thin
Lotus oil, Clary Sage oil, lavender oil, tangerine oil, frankincense oil, attar of rose, thyme linaloe oil, oil of grapefruit, bergamot oil, sweet tea
It seven kinds or seven kinds or more in orange oil and clove bud oil, is directly mixed according to parts by volume, is that those skilled in the art are ripe
The method known, the present invention is to this without limiting.
The present invention provides the compositions described in above-mentioned technical proposal any one in the product for preparing sleep of calming the nerves, improve
In application.
The present invention provides a kind of products calmed the nerves, improve sleep, including the group described in above-mentioned technical proposal any one
Close object.
Active volatile ingredient in the product utilization essential oil provided by the invention calmed the nerves, improve sleep passes through olfactory system
Cerebral nervous system is influenced, to have effects that calm the nerves, improve sleep, the side effect that oral western medicine is brought is avoided, uses
Safely and conveniently.
The application method of the product of the present invention calmed the nerves, improve sleep is specially to draw 100 μ L essential oil compositions to be added dropwise
To being heated in fragrance box；It smells and inhales the time for 30min；The temperature for heating essential oil composition is 60 DEG C.
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：Bitter orange flower oil 1~2；Sieve
Horse oil of chamomile 1~2；Pelargonium oil 1~5；Lemon oil 1~5.The present invention is by by bitter orange flower oil, Rome oil of chamomile, India
The stoste of these pure natural essential oils of certain herbaceous plants with big flowers oil and lemon oil carries out reasonably compatibility, and combines specific ratio so that gained
Compound essential oil have the effect of that good collaboration calms the nerves, improves sleep, and fragrance crowd acceptance is high.In addition, the present invention
Compound essential oil without artificial synthetic essence, do not add preservative, without mineral grease, without the chemical composition for causing allergy, at
Divide safety, is not easy allergy.
In order to further illustrate the present invention, with reference to embodiments to a kind of compound essential oil composition provided by the invention,
It is applied and improves the product of sleep and is described in detail.
Examples 1 to 6；Comparative example 1~6
A kind of compound essential oil includes the component of volume parts as shown in the table.
In order to further prove that advantages of the present invention, the present invention provide the compliance test result of Examples 1 to 6 and comparative example 1~6
Data, to prove beneficial effects of the present invention.
The soothing nerves and assisting sleep compliance test result of Examples 1 to 6 and comparative example 1~6
Zoopery
1) experimental animal：SD mouse, cleaning grade, half male and half female, weight 18g~20g.After mouse adaptability is raised 1 week, with
Machine is divided into blank control group, Examples 1 to 6 group, 1~6 group of comparative example, every group 10.
2) experimental method：Blank control group Neulized inhalation distilled water, Examples 1 to 6 group Neulized inhalation Examples 1 to 6 institute
Compound essential oil described in 1~6 group of compound essential oil stated, comparative example Neulized inhalation comparative example 1~6.Continuous 7d, each 30min, often
100 μ L of secondary dosage.7th day, after all groups of mouse distinguish Neulized inhalation tie substances, pentobarbital solution (50mg/ is injected intraperitoneally
Kg), lift mousetail, after mouse is lain against on backing plate, continue atomized medicine introducing.It is righted instead to mouse so that the time is injected intraperitoneally
It is Sleep latency to penetrate disappearance, and the righting reflex duration is sleeping time.Record Sleep latency time and sleeping time.
3) data processing：Measurement data is with mean ± standard deviationIt indicates, using one-way analysis of variance method
Carry out data processing.P<0.05 indicates statistically significant.
4) experimental result see the table below：
Influence of the difference group compound essential oil to mouse sleep time
Note：Shoulder mark * indicates embodiment, comparative example each group compared with blank control group with significant difference, P ＜ 0.05；
Same column shoulder marking-up female (a, b, c, d, e, f, g, h, i, j, k) indicates to be compared between embodiment and comparative example difference group, indicates not
Indicate that there is significant difference, P ＜ 0.05 with letter
By above-mentioned experiment it is found that 1~6 group of Examples 1 to 6 group and comparative example are compared with blank control group, the sleep of mouse
Time increases, Sleep latency decreases, and have significant difference (P ＜ 0.05), show Examples 1 to 6 with it is right
The essential oil of ratio 1~6 all has certain soothing nerves and assisting sleep effect.The comparison among groups knot of 1~6 group of Examples 1 to 6 group and comparative example
It is remote that fruit shows that the sleeping time of Examples 1 to 6 group is considerably longer than 1~6 group of comparative example, the Sleep latency of Examples 1 to 6 group
Optimal considerably shorter than 1~6 group of comparative example, wherein effect are 3 groups of embodiment.
Clinical trial
1) Subject Population：The insomniac made a definite diagnosis through hospital is selected to participate in experiment, at 25~40 years old age, symptom mainly shows
For：
1. difficulty falling asleep；
2. cannot sleep soundly；
3. early awakening has difficulty in going to sleep after waking up；
4. energy does not restore after sleeping；
5. being easy to be waken up with a start, to sound or light sensitive.
Experimenter is randomly divided into blank control group, Examples 1 to 6 group, 1~6 group of comparative example, every group of 50 people.
2) experimental method：Blank control group is using distilled water, Examples 1 to 6 group using described in the embodiment of the present invention 1~6
Compound essential oil, 1~6 group of comparative example using the compound essential oil described in comparative example 1~6, dosage is 100 μ l/ times, and every night faces
Stacte 60 minutes before sleeping, every 10 days as a treatment course count after 3 courses for the treatment of.
3) curative effect determinate standard
1. curing：Insomnia disappears substantially.
2. improving：Insomnia is mitigated.
3. not being cured：Insomnia is not improved.
It cures and improves and be included in effective statistics.
4) experimental result see the table below：
Influence of the difference group compound essential oil to insomniac
| Group | It cures (people) | It improves (people) | It is not cured (people) | Efficient (%) |
| Blank control group | 0 | 10 | 40 | 20.0% |
| 1 group of embodiment | 25 | 18 | 7 | 86.0% |
| 2 groups of embodiment | 27 | 15 | 8 | 84.0% |
| 3 groups of embodiment | 31 | 17 | 2 | 96.0% |
| 4 groups of embodiment | 29 | 16 | 5 | 90.0% |
| 5 groups of embodiment | 28 | 18 | 4 | 92.0% |
| 6 groups of embodiment | 30 | 15 | 5 | 90.0% |
| 1 group of comparative example | 24 | 15 | 11 | 78.0% |
| 2 groups of comparative example | 22 | 18 | 10 | 80.0% |
| 3 groups of comparative example | 20 | 19 | 11 | 78.0% |
| 4 groups of comparative example | 25 | 11 | 14 | 72.0% |
| 5 groups of comparative example | 18 | 19 | 13 | 74.0% |
| 6 groups of comparative example | 21 | 20 | 9 | 82.0% |
It is above-mentioned the experimental results showed that, the effect of Examples 1 to 6 group is much better than 1~6 group of comparative example and blank control group, table
Bright compound essential oil provided by the present invention has good soothing nerves and assisting sleep effect.
Fragrance crowd's acceptance of Examples 1 to 6 and comparative example 1~6 is investigated
Please 50 experienced professionals form evaluation groups, to the essential oil described in Examples 1 to 6 and comparative example 1~6
Fragrance is evaluated, and evaluation result is as follows：
Acceptance demographics of the crowd to different essential oil fragrance
Acceptance proportion of the crowd to different essential oil fragrance
| Group | It is satisfied | Generally | It is dissatisfied |
| 1 group of embodiment | 82.0% | 16.0% | 2.0% |
| 2 groups of embodiment | 86.0% | 10.0% | 4.0% |
| 3 groups of embodiment | 94.0% | 6.0% | 0.0% |
| 4 groups of embodiment | 90.0% | 8.0% | 2.0% |
| 5 groups of embodiment | 82.0% | 16.0% | 2.0% |
| 6 groups of embodiment | 84.0% | 12.0% | 4.0% |
| 1 group of comparative example | 76.0% | 16.0% | 8.0% |
| 2 groups of comparative example | 70.0% | 20.0% | 10.0% |
| 3 groups of comparative example | 72.0% | 22.0% | 6.0% |
| 4 groups of comparative example | 74.0% | 16.0% | 10.0% |
| 5 groups of comparative example | 78.0% | 16.0% | 6.0% |
| 6 groups of comparative example | 78.0% | 12.0% | 10.0% |
Crowd to the acceptance of different essential oil fragrance experiments have shown that, each embodiment compound essential oil provided by the present invention
Fragrance acceptance is above the compound essential oil of comparative example.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of compound essential oil composition, includes the component of following volume parts：
2. composition according to claim 1, which is characterized in that the compound essential oil composition includes following volume parts
Component：
3. composition according to claim 1, which is characterized in that the compound essential oil composition further includes following any one
The component of kind or several volume parts：
4. composition according to claim 1, which is characterized in that the compound essential oil composition further includes following any one
The component of kind or several volume parts：
5. composition according to claim 3, which is characterized in that the compound essential oil composition includes following volume parts
Component：
6. composition according to claim 5, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Bitter orange flower oil 2；Rome oil of chamomile 2；Pelargonium oil 2；Lemon oil 2；Flos micheliae Albae oil 4；Evening primrose oil 10；Oleum menthae viridis
1.0；Clary Sage oil 1.0；Lavender oil 2；Tangerine oil 2；Frankincense oil 2.
7. composition according to claim 5, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Bitter orange flower oil 1；Rome oil of chamomile 1；Pelargonium oil 2；Lemon oil 2；Lavender oil 3；Attar of rose 2；Thyme linaloe oil 1.0；
Oil of grapefruit 2；Bergamot oil 2；Orange oil 1；Clove bud oil 2.
8. composition according to claim 3, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Bigarabe spends 2；Rome oil of chamomile 2；Pelargonium oil 5；Lemon oil 5；Flos micheliae Albae oil 6；Evening primrose oil 15；Oleum menthae viridis 1.5；
Clary Sage oil 1.5；Lavender oil 4；Tangerine oil 6；Frankincense oil 3；Attar of rose 5；Thyme linaloe oil 1.5；Oil of grapefruit 5；Fingered citron
Mandarin orange oil 5；Orange oil 5；Clove bud oil 3.
9. application of the composition in preparing tranquilizing the mind, improving the product of sleep described in claim 1~8 any one.
10. a kind of product calmed the nerves, improve sleep, which is characterized in that including the combination described in claim 1~8 any one
Object.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432318A (en) * | 2018-12-14 | 2019-03-08 | 北京斯利安药业有限公司 | Compound essential oil, its application and compound essential oil product |
| CN111991463A (en) * | 2020-09-24 | 2020-11-27 | 吾悦堂教育科技(北京)有限公司 | Compound essential oil for treating irregular menstruation |
| CN112336901A (en) * | 2020-11-10 | 2021-02-09 | 湖北物莫生物科技有限公司 | Natural essential oil solid freshener and preparation process thereof |
| CN112516212A (en) * | 2020-11-30 | 2021-03-19 | 南方医科大学 | Compound essential oil for improving sleep and application thereof |
| CN114129630A (en) * | 2021-11-22 | 2022-03-04 | 河北泰城农业科技发展有限公司 | Preparation method and application of essential oil composition for soothing nerves, helping sleep and recovering memory |
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2018
- 2018-05-16 CN CN201810468727.0A patent/CN108635441B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432318A (en) * | 2018-12-14 | 2019-03-08 | 北京斯利安药业有限公司 | Compound essential oil, its application and compound essential oil product |
| CN109432318B (en) * | 2018-12-14 | 2021-07-13 | 北京斯利安药业有限公司 | Compound essential oil, application thereof and compound essential oil product |
| CN111991463A (en) * | 2020-09-24 | 2020-11-27 | 吾悦堂教育科技(北京)有限公司 | Compound essential oil for treating irregular menstruation |
| CN112336901A (en) * | 2020-11-10 | 2021-02-09 | 湖北物莫生物科技有限公司 | Natural essential oil solid freshener and preparation process thereof |
| CN112516212A (en) * | 2020-11-30 | 2021-03-19 | 南方医科大学 | Compound essential oil for improving sleep and application thereof |
| CN114129630A (en) * | 2021-11-22 | 2022-03-04 | 河北泰城农业科技发展有限公司 | Preparation method and application of essential oil composition for soothing nerves, helping sleep and recovering memory |
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