CN108452060B - Compound essential oil composition, application thereof and product for relieving depression - Google Patents

Compound essential oil composition, application thereof and product for relieving depression Download PDF

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CN108452060B
CN108452060B CN201810468707.3A CN201810468707A CN108452060B CN 108452060 B CN108452060 B CN 108452060B CN 201810468707 A CN201810468707 A CN 201810468707A CN 108452060 B CN108452060 B CN 108452060B
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刘月帅
易斌
王曙宾
罗丽莲
肖艳皎
田军
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Beijing Silian Pharmaceutical Industry Co ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract

The invention provides a compound essential oil composition which comprises the following components in parts by volume: 1-4 parts of grapefruit oil; 1-5 parts of citrus oil; 1-3 parts of bergamot oil. According to the invention, the grapefruit oil, the citrus oil and the bergamot oil which are all natural essential oil stock solutions are reasonably compatible, and are combined with a specific proportion ratio, so that the obtained compound essential oil has a good synergistic antidepressant effect, and the acceptance of aroma groups is high. In addition, the compound essential oil does not contain artificially synthesized essence, preservative, mineral oil and fat and chemical components causing allergy, and has safe components and difficult allergy.

Description

Compound essential oil composition, application thereof and product for relieving depression
Technical Field
The invention relates to the technical field of traditional Chinese medicine health care, in particular to a compound essential oil composition, application thereof and a product for relieving depression.
Background
Depression is a mental disorder, and most patients clinically manifest as depressed mood, thought retardation, decreased appetite, decreased mental activity, fatigue, night sweat, decreased libido, haggard face, etc., while few patients manifest as sudden increase in body weight or appetite, insomnia or hypersomnia. With the increasing social competition, the increasing pace of life, the relieving operation of multiple stresses, more and more people are afflicted with depression, the onset age is reduced year by year, the patient group is enlarged year by year, the physical and mental health and the life happiness of people are seriously influenced, and the heavy burden is brought to the whole society.
Depression has the characteristics of high morbidity, great harm and high recurrence rate. The existing commonly used antidepressant drugs have the defects of high toxic and side effects, large adverse reaction, low tolerance and compliance of patients to the drugs, high price, long treatment course, poor taste and the like, so that the drugs can not fully exert the curative effect, the patients can not well insist on taking the drugs and the like, and the treatment and prevention effects are directly influenced.
The plant essential oil has the advantages of high safety, quick metabolism, no residue in vivo, simple, flexible and various using methods, and can be operated by inhalation, fumigation, massage and the like according to personal preference and demand, and is suitable for developing antidepressant products. However, the existing antidepressant essential oil has poor antidepressant effect due to lack of scientificity in component selection or proportion.
Disclosure of Invention
In view of the above, the technical problem to be solved by the present invention is to provide a compound essential oil composition, which has a good antidepressant effect and a high acceptance of aroma groups.
The invention provides a compound essential oil composition which comprises the following components in parts by volume:
1-4 parts of grapefruit oil;
1-5 parts of citrus oil;
1-3 parts of bergamot oil.
Preferably, the compound essential oil composition comprises the following components in parts by volume:
2-4% of grapefruit oil;
2-4 parts of citrus oil;
1-2 parts of bergamot oil.
Preferably, the compound essential oil composition further comprises any one or more of the following components in parts by volume:
Figure BDA0001662499790000021
preferably, the compound essential oil composition further comprises any one or more of the following components in parts by volume:
Figure BDA0001662499790000022
preferably, the compound essential oil composition comprises the following components in parts by volume:
Figure BDA0001662499790000023
Figure BDA0001662499790000031
preferably, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 3; citrus oil 2; bergamot oil 1; marjoram oil 2; 2, cassia oil; clove bud oil 2; thyme oil 1; 1 part of mastic oil; lemon oil 2.
Preferably, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 2; citrus oil 2; bergamot oil 2; rose oil 3; sweet orange oil 2; italian permanent flower oil 3; carnosol 1; roman chamomile oil 1; spearmint oil 1; marjoram oil 2.
Preferably, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 2; citrus oil 4; bergamot oil 2; sweet orange oil 2; 2 parts of rose oil; lemon oil 3.
The invention provides application of the composition in any one of the technical schemes in preparation of a product for relieving depression.
The invention provides a product for relieving depression, which comprises the composition in any one of the technical schemes.
Compared with the prior art, the invention provides a compound essential oil composition which comprises the following components in parts by volume: 1-4 parts of grapefruit oil; 1-5 parts of citrus oil; 1-3 parts of bergamot oil. According to the invention, the grapefruit oil, the citrus oil and the bergamot oil which are all natural essential oil stock solutions are reasonably compatible, and are combined with a specific proportion ratio, so that the obtained compound essential oil has a good synergistic antidepressant effect, and the acceptance of aroma groups is high. In addition, the compound essential oil does not contain artificially synthesized essence, preservative, mineral oil and fat and chemical components causing allergy, and has safe components and difficult allergy.
Detailed Description
The invention provides a compound essential oil composition, application thereof and a product for relieving depression, and a person skilled in the art can use the contents to appropriately improve process parameters for realization. It is expressly intended that all such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the scope of the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.
The invention provides a compound essential oil composition which comprises the following components in parts by volume:
1-4 parts of grapefruit oil;
1-5 parts of citrus oil;
1-3 parts of bergamot oil.
The compound essential oil composition provided by the invention comprises 1-4 parts by volume of grapefruit oil; preferably 2-4 parts by volume of grapefruit oil; more preferably, the grapefruit oil composition comprises 2-3 parts by volume of grapefruit oil.
Grapefruit originates in asia, is an artificially planted tree species that european peoples had since early times been found in approximately 1750 years on the caribbean island of the bardas island of latin america when decorating and arranging yards, and only then began to grow slowly commercially, mainly in the united states, brazil and israel. The grapefruit fruits are picked from a tree with smooth leaves, the tree is 10m high, white flowers are obtained, and the fruits are huge and light yellow. The gland of essential oil is buried in the deep part of the peel, and only a small amount of essential oil can be produced. The grapefruit oil provided by the invention is obtained by squeezing the peel, has fresh and sweet smell and has the citrus fruit flavor.
The compound essential oil composition provided by the invention comprises 1-5 parts by volume of citrus oil; preferably 2-5 parts by volume of citrus oil; more preferably 2-4 parts by volume of citrus oil.
The oil cells of the citrus peel contain rich essential oil, and the weight of the essential oil is about 0.5 to 2 percent of the fresh weight of the peel. The main component of citrus essential oil is d-Limonene (d-Limonene).
The compound essential oil composition provided by the invention comprises 1-3 parts by volume of bergamot oil; preferably, the bergamot oil comprises 1-2 parts by volume.
Bergamot oil is derived from the pericarp of a bitter orange tree, a fruit that is native to india and later produced in both china and italy. The performance of the essential oil is different according to variety differences grown in production places and taste and components, the real essential oil yield of bergamot in the international market is very low, the italian bergamot is the best bergamot and the yield is high, and the components of the essential oil yield contain linalyl acetate, limonene, terpineol and the like; the bergamot has sweet taste with slight sweet taste, and contains nerol, lemon brain, citral and camphene. The classic of traditional Chinese medicine is listed as the medicine for diseases in respiratory tract for a long time, according to the record of the materia medica bibliography: bergamot is slightly bitter, sour and warm in taste, enters liver, spleen, stomach and lung channels, has the functions of soothing liver, regulating qi, eliminating dampness and reducing phlegm, and can be used for qi stagnation of liver and stomach and distention of chest and hypochondrium. Bergamot is applied to aromatherapy at the earliest because of the bactericidal effect of bergamot itself, the efficacy of bergamot is not inferior to that of lavender, and the bergamot can resist indoor dust and mites, so that the bergamot is commonly used for relieving allergic rhinitis and infantile asthma, and is scented indoors, so that people can feel relaxed and happy, and even the bergamot has the effects of purifying air and preventing the spread of viruses; it can be used for massaging skin, is helpful for oily skin such as acne, and can balance sebaceous gland secretion of oily skin.
According to the invention, the grapefruit oil, the citrus oil and the bergamot oil which are all natural essential oil stock solutions are reasonably compatible, and are combined with a specific proportion ratio, so that the obtained compound essential oil has a good synergistic antidepressant effect, and the acceptance of aroma groups is high. In addition, the compound essential oil does not contain artificially synthesized essence, preservative, mineral oil and fat and chemical components causing allergy, and has safe components and difficult allergy.
In some embodiments, the compound essential oil composition comprises the following components in parts by volume:
2-4% of grapefruit oil;
2-4 parts of citrus oil;
1-2 parts of bergamot oil.
According to the invention, the compound essential oil composition preferably further comprises any one or more of the following components in parts by volume:
0-3 parts of origanum majorana oil; 0-3 parts of cassia oil; 0-3 parts of clove bud oil; 0-1.5 parts of thyme oil; 0-1.5 parts of mastic oil; 0-4 parts of lemon oil; 0-4 parts of rose oil; 0-6 parts of sweet orange oil; 0-4% of Italian permanent flower oil; 0-1.5 parts of Happy sage oil; 0-1.5 parts of Roman chamomile oil; 0-1.5 parts of spearmint oil.
More preferably, the composition further comprises any three or more of the following components in parts by volume:
0-3 parts of origanum majorana oil; 0-3 parts of cassia oil; 0-3 parts of clove bud oil; 0-1.5 parts of thyme oil; 0-1.5 parts of mastic oil; 0-4 parts of lemon oil; 0-4 parts of rose oil; 0-6 parts of sweet orange oil; 0-4% of Italian permanent flower oil; 0-1.5 parts of Happy sage oil; 0-1.5 parts of Roman chamomile oil; 0-1.5 parts of spearmint oil.
According to the invention, the compound essential oil composition preferably further comprises any one or more of the following components in parts by volume:
1-3 parts of marjoram oil; 1-3 parts of cassia oil; 1-3 parts of clove bud oil; 0.5-1.5 parts of thyme oil; 0.5-1.5 parts of mastic oil; 1-4 parts of lemon oil; 1-4 parts of rose oil; 1-6 parts of sweet orange oil; 2-4 parts of Italian permanent flower oil; 0.5-1.5 parts of Happy sage oil; 0.5-1.5 parts of Roman chamomile oil; 0.5-1.5 parts of spearmint oil.
The marjoram essential oil is obtained from distilled dried flowers, has strong phenol, grass and wood flavors, and is very similar to thyme. Marjoram is a herbaceous plant with a height of less than 1 meter, and has a stiff and hairy stem, wide and round leaves, a pointed tip at the front end, and purple flowers growing at the top, and is produced in the middle east, spain, france, baldry peninsula and the united states. The marjoram oil is preferably 1-2 parts by volume.
Cinnamon oil is currently used as a spice and is used in all directions of China. It is mainly used as flavoring for meat cooking, and also used for pickling, soaking in wine, and baking food such as bread, cake, and cake. The amount thereof is determined as required. Also one of the main raw materials for preparing the five-spice powder. It can also be used for extracting essential oil. The cassia oil is preferably 1-2 parts by volume.
The flos Caryophylli bud oil is volatile oil obtained by distilling dried bud of flos Caryophylli of Myrtaceae. Warm stomach and kidney. Can be used for treating stomach cold, pain and distention, singultus, vomiting and diarrhea, arthralgia, hernia pain, halitosis, and toothache. The clove bud oil is preferably 1-2 parts by volume.
Thyme oil is obtained by steam distillation of aerial parts of thyme (Thymus vulgaris L.) belonging to Labiatae, which enter into flowering phase. Has cool and dry medicinal herb fragrance, and has fragrance of linalool, terpinene, etc. The main components are thymol (30-70%) and carvacrol (2-15%). The thyme oil is preferably 0.5-1 part by volume.
Boswellia oil is obtained by steam distillation of gum resin exuded from trunk of Boswellia carterii Birdw (Boswellia carterii. and other Boswellia species). Colorless to pale yellow. Has light lemon fragrance with fresh and sweet cream fragrance. The main components include dipentene, scirprene, levo-camphor esters, p-cymene, verbenone (verbenol), etc. The mastic oil is preferably 0.5-1 part by volume.
Lemon oil is obtained by squeezing fresh pericarp of lemon. Is yellow liquid and has strong lemon fragrance. The lemon oil is preferably 2-3 parts by volume.
The rose oil is prepared from fresh flos Rosae Rugosae by steam distillation. The oil yield is generally 0.02-0.04%. Roses are very diverse, but can be used for producing mainly rose cockles, mary roses, rose leaves and rose black which meet the requirements of spices. The fresh flowers should be processed within 1h after being picked. Rose oil is a light yellow to yellow liquid. The rose oil is preferably 2-3 parts by volume.
The sweet orange oil is obtained by cold grinding fresh fruits of sweet oranges in Rutaceae or cold pressing fresh fruit peels, and the yield is 3.5-3.7%: the crushed slag filtered out during cold grinding and cold pressing and the collected Tuanhua peel are extracted by adopting a correct finishing method, the yield of the cold pressed peel is 0.8-1.0%, and the yield of the distilled oil is 0.4-0.7%. The sweet orange oil is preferably 2-4 parts by volume.
Italian permanent flower is a wild plant, the flower color is dark yellow, the leaves are silver green and have pepper flavor, the stem of the Italian permanent flower is 60 centimeters long, and the variety is various. Essential oils are produced predominantly in europe, particularly italy, france and south srafv. If distillation is carried out immediately within 24 hours after harvest, essential oil with better quality can be obtained, and the more extractable amount of the younger plants is. The Italian permanent flower oil is preferably 2-3 parts by volume.
Sage, english name: CLARY SAGE are provided. The small shrub plant is a herbaceous shrub plant, the leaves are very special, light purple green, the flowers are blue, the small shrub plant belongs to a herbaceous shrub type, the height is 50-70 centimeters on average, the main production area is Balganjuan, essential oil is distilled from the leaves and flowers of the small shrub plant, the small shrub plant is light yellow green, and the small shrub plant has sweet taste and fragrance of fennel and camphor. The preferred volume part of the salvia sclarea oil is 0.5-1.
Roman chamomile is a perennial plant, originally distributed in south to western Europe, and is now planted in many countries. The flower heart is yellow, the petals are white, and the height can be as long as 60 cm. The distilled essential oil is yellow in color and has sweet and sweet herbal flavor. The Roman chamomile oil is preferably 0.5-1 part by volume.
The green mint leaves are wrinkled and sharp, and the flowers are purple and can grow to 90 cm high. Extraction site of spearmint oil: flowering top, leaves; the extraction method comprises the following steps: and (5) distilling. The preferred spearmint oil is 0.5-1 part by volume.
The grapefruit oil, the citrus oil, the bergamot oil, the marjoram oil, the cinnamon oil, the clove bud oil, the thyme oil, the frankincense oil, the lemon oil, the rose oil, the sweet orange oil, the Italian permanent flower oil, the Happy sage oil, the Roman chamomile oil and the spearmint oil are not limited in source and can be sold in the market.
In some embodiments of the invention, the compound essential oil composition comprises the following components in parts by volume:
2-3 parts of grapefruit oil; 2-4 parts of citrus oil; 1-2 parts of bergamot oil; 0-2 parts of origanum majorana oil; 0-2 parts of cassia oil; 0-2 parts of clove bud oil; 0-1 parts of thyme oil; 0-1% of mastic oil; 0-3 parts of lemon oil; 0-3 parts of rose oil; 0-2% of sweet orange oil; 0-3 parts of Italian permanent flower oil; 0-1 parts of Happy sage oil; 0-1 parts of Roman chamomile oil; 0-1 parts of spearmint oil.
In a part of preferred embodiments of the present invention, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 3; citrus oil 2; bergamot oil 1; marjoram oil 2; 2, cassia oil; clove bud oil 2; thyme oil 1; 1 part of mastic oil; lemon oil 2.
In a part of preferred embodiments of the present invention, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 2; citrus oil 2; bergamot oil 2; rose oil 3; sweet orange oil 2; italian permanent flower oil 3; carnosol 1; roman chamomile oil 1; spearmint oil 1; marjoram oil 2.
In a part of preferred embodiments of the present invention, the compound essential oil composition comprises the following components in parts by volume:
grapefruit oil 2; citrus oil 4; bergamot oil 2; sweet orange oil 2; 2 parts of rose oil; lemon oil 3.
The inventor creatively discovers that three or more than three of marjoram oil, cassia oil, clove bud oil, thyme oil, frankincense oil, lemon oil, rose oil, sweet orange oil, Italian permanent flower oil, Happy sage oil, Roman chamomile oil and spearmint oil are matched on the basis of the grapefruit oil, the citrus oil and the bergamot oil in a specific ratio; preferably, more than three and less than ten kinds of the essential oil are selected to be compatible and cooperated with grapefruit oil, citrus oil and bergamot oil, and the finally prepared compound essential oil has a remarkable synergic antidepressant effect and is high in acceptance of aroma population.
In addition, the compound essential oil of the invention also has the following characteristics: a contains no essence: the natural essential oil stock solution is used to replace artificially synthesized essence. Therefore, the product has the advantages of pure quality, mildness, safety, pleasant aroma, no irritation and aromatherapy effect. b no addition of preservatives: most of the natural essential oils have the functions of antibiosis and sterilization, and no preservative is needed. c contains no mineral oil: all natural plant essential oil is used. d contains no chemical components causing allergy: the pure natural essential oil does not contain components which can cause allergy such as artificial essence, lanolin, alcohol, chemical sun-screening agent, pigment and the like, and the raw materials added and used each time are proved by experiments to not cause allergy to human bodies. e flavor change: the fragrance changes gradually along with the time, different experiences and feelings can be brought to people by different fragrances, and people can have different moods. f, improving the air quality: most of the natural essential oils have antibacterial and bactericidal effects, and can improve air quality and keep air fragrant and fresh. The safety of the compound essential oil is higher than that of the single essential oil: the compound essential oil obviously reduces chemical components such as phenols and aldehydes and ketones which have certain toxicity and irritation to human bodies in each single essential oil, and improves the chemical components such as terpenes and alcohols which have high safety to human bodies and no sensitive irritation.
The preparation method of the present invention is to mix grapefruit oil, citrus oil and bergamot oil directly according to volume parts, which is a method well known to those skilled in the art, and the present invention is not limited thereto.
Or the grapefruit oil, the citrus oil and the bergamot oil are mixed with three or more of marjoram oil, cinnamon oil, clove bud oil, thyme oil, frankincense oil, lemon oil, rose oil, sweet orange oil, Italian permanent flower oil, Happy sage oil, Roman chamomile oil and spearmint oil according to volume parts, and the method is a method well known by the technicians in the field and is not limited in the invention.
The invention provides application of the composition in any one of the technical schemes in preparation of a product for relieving depression.
The invention provides a product for relieving depression, which comprises the composition in any one of the technical schemes.
The product for relieving depression provided by the invention has the efficacy of relieving depression by influencing the cerebral nervous system through the active volatile components in the essential oil and the olfactory system, avoids the side effects caused by oral western medicines, and is safe and convenient to use.
The application method of the product for relieving depression provided by the invention specifically comprises the steps of sucking 100 mu L of essential oil composition, dripping the essential oil composition into an aromatherapy box, and heating; sniffing for 30 min; the essential oil composition is heated to a temperature of 60 ℃.
The invention provides a compound essential oil composition which comprises the following components in parts by volume: 1-4 parts of grapefruit oil; 1-5 parts of citrus oil; 1-3 parts of bergamot oil. According to the invention, the grapefruit oil, the citrus oil and the bergamot oil which are all natural essential oil stock solutions are reasonably compatible, and are combined with a specific proportion ratio, so that the obtained compound essential oil has a good synergistic antidepressant effect, and the acceptance of aroma groups is high. In addition, the compound essential oil does not contain artificially synthesized essence, preservative, mineral oil and fat and chemical components causing allergy, and has safe components and difficult allergy.
In order to further illustrate the present invention, the following detailed description of a compound essential oil composition, its application and a product for relieving depression provided by the present invention is provided in connection with the examples.
Examples 1 to 7; comparative examples 1 to 6
A compound essential oil comprises the components in parts by volume as shown in the following table.
Figure BDA0001662499790000091
Figure BDA0001662499790000101
Figure BDA0001662499790000102
Figure BDA0001662499790000111
To further demonstrate the advantages of the present invention, the present invention provides the effect verification data of examples 1-7 and comparative examples 1-6.
1. Depression-preventing Effect verification of examples 1 to 7 and comparative examples 1 to 6
The antidepressant effects of examples 1 to 7 and comparative examples 1 to 6 were investigated using a forced swimming test or a tail overhang test for mice.
Selecting SPF male Kunming mice as test objects, randomly dividing the mice into 14 groups of 10 mice each, after adaptive feeding for 3 days, respectively putting the mice into a 600 x 400 x 200mm fresh-keeping box for smelling fragrance, wherein 1 group is a blank control group, and putting 100 mu L of distilled water; 2-8 groups are examples 1-7 groups, and 100 μ L of the compound essential oil of examples 1-7 is added; 9-14 groups are comparative examples 1-6, and 100 μ L of the essential oil described in comparative examples 1-6 was added. The test was carried out 30min after smelling fragrance on the fourth day.
Smelling the fragrance: adding distilled water and essential oil into the fragrance box, placing in a place which can not be contacted by mouse in the fresh-keeping box with normal air vent, placing mouse in the fresh-keeping box, heating the fragrance box at 60 deg.C to volatilize distilled water and essential oil, and smelling for 30 min. Mice were free to eat and drink water during the experiment.
Forced swimming test or tail hanging test for mice
Forced Swimming Test (FST)
Each mouse was placed individually in a cylindrical glass jar 30cm high and 18cm in diameter, at a water depth of 10cm and a water temperature of 23 + -2 deg.C. After the mice are put into water, the mice are firstly adapted to swimming for 2min, and then the cumulative immobile time of the mice swimming within the next 4min is recorded. The judgment standard of the mouse immobility state is as follows: the four limbs of the mouse stop struggling in a static floating state on the water surface, or only slight limb movement for maintaining body balance shows a disappointing state.
Tail Suspension Test (TST)
The tail suspension test was performed 24h after the forced swim test of the mice was completed. The medical adhesive tape with the hook is adhered to the position 1cm away from the tail tip of the mouse, the hook is hung on the hole of the cross rod of the support so that the mouse cannot move, the mouse is in an upside-down hanging state, the head of the mouse is 5cm away from the black desktop, and one mouse is hung each time. After hanging, the mice were allowed to adapt to an inverted posture for 2min, and then the cumulative time of standing the tail in the next 4min was recorded. The judgment standard of the motionless state is as follows: the mouse hanging upside down stops shaking to struggle or to maintain a posture without other actions showing disappointed state.
Test results data are presented as mean ± standard deviation and variance analysis is used to compare differences between groups.
Influence of different groups of essential oils on immobility time of forced swimming of mice
Group of Swimming immobility time(s) Suspension tail motionless time(s)
Blank control group 158.4±1.10 132.9±0.89
EXAMPLE 1 group 95.0±0.66*g 80.7±1.18*e
EXAMPLE 2 group 92.2±1.01*h 78.8±1.06*f
EXAMPLE 3 group 84.0±0.64*k 66.8±0.80*j
EXAMPLE 4 group 82.1±1.09*l 63.8±1.08*k
EXAMPLE 5 group 85.9±1.07*j 69.3±1.18*i
EXAMPLE 6 group 88.8±1.08*i 73.7±1.33*h
EXAMPLE 7 group 89.4±0.72*i 76.9±1.14*g
Comparative example 1 group 103.9±0.78*d 86.8±1.06*d
Comparative example 2 group 101.8±1.06*e 89.6±1.29*c
Comparative example 3 group 112.9±0.99*b 90.8±1.01*b
Comparative example 4 group 100.3±1.13*f 87.4±1.18*d
Comparative example 5 group 108.5±0.72*c 92.7±0.91*a
Comparative example 6 group 123.4±0.96*a 88.7±1.33*c
Note: the shoulder marks indicate that each group of the examples and the comparative examples has significant difference compared with a blank control group, and P is less than 0.05; the same row of shoulder letters (a, b, c, d, e, f, g, h, i, j, k, l) indicate that the comparison between different groups of the examples and the comparative examples is carried out, and different letters indicate that the comparison shows that the comparison has significant difference, and P is less than 0.05
As can be seen from the above tests, the immobility time for swimming and the immobility time for suspending tail of the mice in the groups of examples 1 to 7 and the groups of comparative examples 1 to 6 are reduced compared with the blank control group, and have significant difference (P is less than 0.05), which shows that the essential oils of the examples 1 to 7 and the comparative examples 1 to 6 have certain antidepressant effect. The results of the comparison between the groups of examples 1-7 and the groups of comparative examples 1-6 show that the swimming immobility time and the tail immobility time of the groups of examples 1-7 are far shorter than those of the groups of comparative examples 1-6, and the optimal effect is the group of example 4. The results suggest that the combination of grapefruit oil, citrus oil and bergamot oil in a certain proportion can exert a synergistic effect and obtain a better anti-depression effect, and the further addition of one or more of marjoram oil, cinnamon oil, clove bud oil, thyme oil, frankincense oil, lemon oil, rose oil, citrus oil, Italian permanent flower oil, Happy sage oil, Roman chamomile oil and spearmint oil can further improve the effect of the composition.
2. Fragrance acceptance test for examples 1 to 7 and comparative examples 1 to 6
Please take 50 experienced professionals to form an evaluation team to evaluate the flavor of the essential oils described in examples 1-7 and comparative examples 1-6, and the evaluation results are as follows:
statistics of receptivity of crowd to different essential oil fragrances
Figure BDA0001662499790000131
Figure BDA0001662499790000141
The ratio of receptivity of people to different essential oil fragrances
Group of Satisfaction In general Is not satisfied with
EXAMPLE 1 group 80.0％ 18.0％ 2.0％
EXAMPLE 2 group 84.0％ 14.0％ 2.0％
EXAMPLE 3 group 88.0％ 12.0％ 0.0％
EXAMPLE 4 group 92.0％ 8.0％ 0.0％
EXAMPLE 5 group 86.0％ 14.0％ 0.0％
EXAMPLE 6 group 84.0％ 14.0％ 2.0％
EXAMPLE 7 group 80.0％ 16.0％ 4.0％
Comparative example 1 group 78.0％ 16.0％ 6.0％
Comparative example 2 group 70.0％ 22.0％ 8.0％
Comparative example 3 group 76.0％ 18.0％ 6.0％
Comparative example 4 group 74.0％ 16.0％ 10.0％
Comparative example 5 group 72.0％ 20.0％ 8.0％
Comparative example 6 group 78.0％ 14.0％ 8.0％
The test results show that the dissatisfaction degrees of the people groups for the fragrances of different essential oils are all lower than those of the comparative examples, so that the fragrance acceptance degrees of the examples are all higher than those of the comparative examples.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (8)

1. A compound essential oil composition for relieving depression comprises the following components in parts by volume:
1-4 parts of grapefruit oil;
1-5 parts of citrus oil;
1-3 parts of bergamot oil;
1-3 parts of marjoram oil;
1-3 parts of cassia oil;
1-3 parts of clove bud oil;
0.5-1.5 parts of thyme oil;
0.5-1.5 parts of mastic oil;
1-4 parts of lemon oil;
1-4 parts of rose oil;
1-6 parts of sweet orange oil;
2-4 parts of Italian permanent flower oil;
0.5-1.5 parts of Happy sage oil;
0.5-1.5 parts of Roman chamomile oil;
0.5-1.5 parts of spearmint oil.
2. The composition as claimed in claim 1, wherein the volume parts of grapefruit oil, citrus oil and bergamot oil in the compound essential oil composition are as follows:
2-4% of grapefruit oil;
2-4 parts of citrus oil;
1-2 parts of bergamot oil.
3. The composition according to claim 1, characterized by consisting of the following parts by volume of the components:
2-3 parts of grapefruit oil;
2-4 parts of citrus oil;
1-2 parts of bergamot oil;
1-2 parts of origanum majorana oil;
1-2 parts of cassia oil;
1-2 parts of clove bud oil;
0.5-1% of thyme oil;
0.5-1% of mastic oil;
1-3 parts of lemon oil;
1-3 parts of rose oil;
1-2 parts of sweet orange oil;
2-3 parts of Italian permanent flower oil;
0.5-1 parts of Happy sage oil;
0.5-1 parts of Roman chamomile oil;
0.5-1% of spearmint oil.
4. The compound essential oil composition for relieving depression is characterized by comprising the following components in parts by volume:
grapefruit oil 3; citrus oil 2; bergamot oil 1; marjoram oil 2; 2, cassia oil; clove bud oil 2; thyme oil 1; 1 part of mastic oil; lemon oil 2.
5. The compound essential oil composition for relieving depression is characterized by comprising the following components in parts by volume:
grapefruit oil 2; citrus oil 2; bergamot oil 2; rose oil 3; sweet orange oil 2; italian permanent flower oil 3; carnosol 1; roman chamomile oil 1; spearmint oil 1; marjoram oil 2.
6. The compound essential oil composition for relieving depression is characterized by comprising the following components in parts by volume:
grapefruit oil 2; citrus oil 4; bergamot oil 2; sweet orange oil 2; 2 parts of rose oil; lemon oil 3.
7. Use of the composition of any one of claims 1-6 for the preparation of a product for alleviating depression.
8. A product for alleviating depression, which consists of the composition according to any one of claims 1 to 6.
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