CN108452060A - Compound essential oil composition, its application and the product for alleviating depression - Google Patents
Compound essential oil composition, its application and the product for alleviating depression Download PDFInfo
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- CN108452060A CN108452060A CN201810468707.3A CN201810468707A CN108452060A CN 108452060 A CN108452060 A CN 108452060A CN 201810468707 A CN201810468707 A CN 201810468707A CN 108452060 A CN108452060 A CN 108452060A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
Abstract
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：Oil of grapefruit 1~4；Tangerine oil 1~5；Bergamot oil 1~3.The present invention combines specific ratio by the way that the stoste of oil of grapefruit, tangerine oil and bergamot oil these pure natural essential oils is carried out rational compatibility so that the compound essential oil of gained has good collaboration antidepressant effect, and fragrance crowd acceptance is high.In addition, the compound essential oil of the present invention without artificial synthetic essence, do not add preservative, without mineral grease, without the chemical composition for causing allergy, ingredient safety is not easy allergy.
Description
Technical field
The present invention relates to health protection with Chinese medicine technical field, more particularly, to a kind of compound essential oil composition, its application and
Alleviate the product of depression.
Background technology
Depression belongs to a kind of psychotic disorder, and most of patients clinical manifestation is depressed, retardation of thinking, appetite drop
Low, bulesis decline, weak, night sweat, sexual hypoesthesia, with a haggard face etc., small number of patients then show as weight or appetite abruptly increase,
Insomnia or more dormancies.With increasingly sharpening for social competition, the increasingly quickening of rhythm of life, the weary art of releiving of multiple pressure is more next
By the torment of depression, age of onset declines more people year by year, and patient population expands year by year, drastically influences the body of people
Heart Health and Living happiness, also brings white elephant to entire society.
Depression has the characteristics that incidence is high, harmfulness is big, high recurrence rate.Currently used antidepressant is due to poison
Side effect height, erious adverse reaction, patient reduces the tolerance and compliance of drug, expensive, the course for the treatment of is long, poor taste etc. is more
The defect of aspect, cause drug that cannot give full play to curative effect, patient cannot adhere to very well medication etc., directly affect treatment and prevention
Effect.
Plants essential oil has that safe, metabolism is fast, in vivo without any residual, and application method simple and flexible is various, can
According to personal hobby and demand, the advantages of operation, to be suitable for developing anti-suppression with inhalation, fumigating system, massage etc.
Strongly fragrant product.But selection or proportions of the current antidepression essential oil due to component lack science, and antidepressant effect is not good enough.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide a kind of compound essential oil composition, the present invention provides
Compound essential oil composition there is good antidepressant effect, and fragrance crowd acceptance is high.
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：
Oil of grapefruit 1~4；
Tangerine oil 1~5；
Bergamot oil 1~3.
Preferably, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 2~4；
Tangerine oil 2~4；
Bergamot oil 1~2.
Preferably, the compound essential oil composition further includes the component of any one or a few following volume parts：
Preferably, the compound essential oil composition further includes the component of any one or a few following volume parts：
Preferably, the compound essential oil composition includes the component of following volume parts：
Preferably, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 3；Tangerine oil 2；Bergamot oil 1；Marjoram oil 2；Cassia oil 2；Clove bud oil 2；Thyme linaloe oil 1；
Frankincense oil 1；Lemon oil 2.
Preferably, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 2；Tangerine oil 2；Bergamot oil 2；Attar of rose 3；Orange oil 2；Italian permanent caul-fat 3；Happy rat-tail
Careless oil 1；Rome oil of chamomile 1；Oleum menthae viridis 1；Marjoram oil 2.
Preferably, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 2；Tangerine oil 4；Bergamot oil 2；Orange oil 2；Attar of rose 2；Lemon oil 3.
The present invention provides the compositions described in a kind of above-mentioned technical proposal any one to prepare the product for alleviating depression
In application.
The present invention provides a kind of products for alleviating depression, including the composition described in above-mentioned technical proposal any one.
Compared with prior art, the present invention provides a kind of compound essential oil composition, include the component of following volume parts：
Oil of grapefruit 1~4；Tangerine oil 1~5；Bergamot oil 1~3.The present invention by by oil of grapefruit, tangerine oil and bergamot oil this
The stoste of a little pure natural essential oils carries out rational compatibility, and combines specific ratio so that the compound essential oil of gained has
Good collaboration antidepressant effect, and fragrance crowd acceptance is high.In addition, the compound essential oil of the present invention is free of artificial synthesized perfume (or spice)
Essence, do not add preservative, without mineral grease, without the chemical composition for causing allergy, ingredient safety is not easy allergy.
Specific implementation mode
The present invention provides a kind of compound essential oil composition, its application and the product for alleviating depression, people in the art
Member can use for reference present disclosure, be suitably modified technological parameter realization.In particular, it should be pointed out that all similar substitutions and modifications
Apparent to those skilled in the art, they shall fall within the protection scope of the present invention.The present invention method and answer
With being described by preferred embodiment, related personnel can obviously not depart from the content of present invention, in spirit and scope
Methods herein and application are modified or are suitably changed and combined, to realize and apply the technology of the present invention.
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：
Oil of grapefruit 1~4；
Tangerine oil 1~5；
Bergamot oil 1~3.
Compound essential oil composition provided by the invention includes the oil of grapefruit of 1~4 parts by volume；Preferably include 2~4 parts by volume
Oil of grapefruit；More preferably include the oil of grapefruit of 2~3 parts by volume.
Grape fruit originates from Asia, it is the seeds of artificial growth, and early stage European brings when decoration, arrangement garden use,
It was about found on the Caribbean island in Latin America Barbados archipelago in 1750, just starts slowly to be commercialized kind later
It plants, is mainly planted in the U.S., Brazil and Israel.Grape fruit fruit is picked from a kind of tree that blade is smooth, and tree is high
10m, white flowers, fruit are huge, faint yellow.Essential oil gland is embedded in pericarp depths, can only produce a small amount of essential oil.Grape fruit is cool in nature, taste
There is sweet acid heat-clearing, the benefits of quenching the thirst, oil of grapefruit provided by the invention to be squeezed by pericarp and be obtained, and smell is pure and fresh, fragrant and sweet, there is mandarin orange
The fruit flavor of tangerine.
Compound essential oil composition provided by the invention includes the tangerine oil of 1~5 parts by volume；Preferably include 2~5 parts by volume
Tangerine oil；More preferably include the tangerine oil of 2~4 parts by volume.
Containing abundant essential oil, about the 0.5%~2% of pericarp fresh weight in the oil vacuole of orange peel.The master of citrus essential oil
It is (R)-4-isopropenyl-1-methyl-1-cyclohexene (d-Limonene) to want ingredient.
Compound essential oil composition provided by the invention includes the bergamot oil of 1~3 parts by volume；Preferably include 1~2 parts by volume
Bergamot oil.
Bergamot oil originates in India from a kind of pericarp of bigarabe tree, such fruit, later China and Italy all
There is production.The breed difference to grow according to the place of production in efficiency, also some differences on taste and ingredient, in the international market really
Bergamot yield is few, Italian bergamot, is the good mandarin orange of shellfish actually, and yield is more, the camphor tree of virtue containing acetic acid in ingredient
Fat, limonene, terpinol etc.；With slightly sweet in the bergamot taste sweet tea of China, nerol, lemon brain, lemon are contained in the inside
Aldehyde, lemon alcohol and note alkenes etc..The medication of the disease by it in terms of being classified as respiratory tract very early, foundation in the ancient books and records of Chinese medicine
《The rigid mesh of book on Chinese herbal medicine》Record：Bergamot taste slightly bitter, acid, temperature, enter liver, spleen, stomach, lung channel, have dispersing stagnated hepatoqi, eliminating dampness and eliminating phlegm do
With can be used for stagnation of liver-QI and stomach-QI, chest side of body flatulence.It is because the sterilization that itself has is imitated that bergamot is employed for virtue earliest, which to be treated,
Fruit, effect is no less than lavender, can fight indoor dirt and walk haltingly, therefore is usually used in the alleviation of allergic rhinitis and children's asthma,
Indoor aroma diffusing can not only allow people to feel relief happy, or even have purification air, the effect of the propagation of pre- anti-virus；For skin
Skin is massaged, helpful for Oilys such as acne, can balance the smegma of oily skin.
The present invention is by reasonably being matched the stoste of oil of grapefruit, tangerine oil and bergamot oil these pure natural essential oils
5, and combine specific ratio so that the compound essential oil of gained has good collaboration antidepressant effect, and fragrance crowd
Acceptance is high.In addition, the present invention compound essential oil without artificial synthetic essence, do not add preservative, without mineral grease, be free of
The chemical composition of allergy, ingredient safety is caused to be not easy allergy.
In some embodiments, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 2~4；
Tangerine oil 2~4；
Bergamot oil 1~2.
According to the present invention, the compound essential oil composition preferably further includes the group of any one or a few following volume parts
Point：
Marjoram oil 0~3；Cassia oil 0~3；Clove bud oil 0~3；Thyme linaloe oil 0~1.5；Frankincense oil 0~1.5；Lemon
Lemon oil 0~4；Attar of rose 0~4；Orange oil 0~6；Italian permanent caul-fat 0~4；Clary Sage oil 0~1.5；Rome ocean is sweet
Elecampane oil 0~1.5；Oleum menthae viridis 0~1.5.
It more preferably further include the component of following arbitrary three kinds or more volume parts：
Marjoram oil 0~3；Cassia oil 0~3；Clove bud oil 0~3；Thyme linaloe oil 0~1.5；Frankincense oil 0~1.5；Lemon
Lemon oil 0~4；Attar of rose 0~4；Orange oil 0~6；Italian permanent caul-fat 0~4；Clary Sage oil 0~1.5；Rome ocean is sweet
Elecampane oil 0~1.5；Oleum menthae viridis 0~1.5.
According to the present invention, the compound essential oil composition preferably further includes the group of any one or a few following volume parts
Point：
Marjoram oil 1~3；Cassia oil 1~3；Clove bud oil 1~3；Thyme linaloe oil 0.5~1.5；Frankincense oil 0.5~
1.5；Lemon oil 1~4；Attar of rose 1~4；Orange oil 1~6；Italian permanent caul-fat 2~4；Clary Sage oil 0.5~1.5；
Rome oil of chamomile 0.5~1.5；Oleum menthae viridis 0.5~1.5.
Wherein, marjoram essential oil is from the flower for distilling its drying, and fragrance is in strong phenol taste, careless taste, wooden taste, very
Similar thyme.Marjoram is a kind of herbaceous plant of the height less than 1 meter, and stem is strong and has fine hair shape, and leaf is round in width,
Front end is pointed, and flower is longer than top, and purple originates in the Middle East, Spain, France, the Balkan Peninsula and the U.S..Horse of the present invention
Yu Lan oil is preferably 1~2 parts by volume.
Cassia oil is commonly used for spice at present, and China has used the Zhou Dynasty.It is mainly used as meat cooking condiment, is also used for
The bakery products such as pickling, infusing drugs in wine and bread, cake, cake.Its dosage depends on the needs.Also be five-spice powder processed primary raw material it
One.It can also be used for extraction essential oil.Cassia oil of the present invention is preferably 1~2 parts by volume.
Clove bud oil is the dry flower of plant clove of myrtaceae through the volatile oil of distillation gained.Warm stomach, warm kidney.It is main
Control swollen stomach cold pain, hiccup, vomiting and diarrhoea, numbness pain, colic, halitosis, toothache.Clove bud oil of the present invention is preferably 1~2 volume
Part.
Thyme linaloe oil is to enter the aerial part at florescence by labiate thyme (Thymus vulgaris L.) to pass through
Steam distillation obtains.Have herbal that is refrigerant, doing coke, has the faint scents such as linalool, terpinene concurrently.Principal component is Thymol
(30%~70%), carvacrol (2%~15%).Thyme linaloe oil of the present invention is preferably 0.5~1 parts by volume.
Frankincense oil is set by olive subject plant frankincense (Boswellia carterii Birdw. and other Boswellia carterii category kinds)
The gum resin of dry exudation, obtains through steam distillation.To be colourless to pale yellow.The light lemonene of tool sweetness cream perfumed ribbon.It is main at
Dividing has dipentene, material pine alkene, levo-camphor esters, cymene, verbenone (verbenone), verbenol
Deng.Frankincense oil of the present invention is preferably 0.5~1 parts by volume.
Lemon oil is obtained by the fresh peel of lemon through squeezing.For yellow liquid, there is strong citris aromas.Institute of the present invention
It is preferably 2~3 parts by volume to state lemon oil.
Attar of rose is that fresh rose is made through steam distillation.Oil yield is generally 0.02%~0.04%.Rose
Kind it is very more, but can be used to produce meet fragrance requirement mainly have wrinkle leaf rose, big horse color rose, Rosa centifolia and ink
Red Chinese rose.Fresh flower picking after should in 1h working process.Attar of rose is light yellow to yellow liquid.Attar of rose of the present invention is excellent
It is selected as 2~3 parts by volume.
Orange oil is obtained by rutaceae sweet orange fresh fruit cold grinding or by fresh fruit skin cold press, and yield 3.5%~
3.7%：The barrier of disintegrating slag and collection that sieving when cold grinding, cold press is gone out is dissipated pericarp and is extracted using correct method for sorting, cold press fruit
Skin yield 0.8%~1.0%, distilled oil yield 0.4%~0.7%.Orange oil of the present invention is preferably 2~4 parts by volume.
Italian permanent flower is a kind of wild plant, and pattern is dark yellow, and blade silver is green and carries pepper taste, and stem length 60 is public
Point, it is various in style.The main product of essential oil in Europe, especially Italy, France and Yugoslavia.If 24 hours after harvest
It inside distills immediately, by the preferable essential oil of available quality, the amount that tenderer plant can extract is the more.Italy of the present invention is forever
Long caul-fat is preferably 2~3 parts by volume.
Salvia japonica, English name：CLARY SAGE.Draft small shrub plant, leaf is very special, is pale purple green,
Flower is blue, belongs to draft shrub type, averagely 50~70 centimeters of height, the main place of production is the Balkan Peninsula, and essential oil is distilled from it
Leaf and flower are in chartreuse, the fragrance with some sweet tastes and fennel, camphor.Clary Sage oil of the present invention is preferably
For 0.5~1 parts by volume.
Rome chamomile is perennial plant, and original is distributed in southern Europe to West Europe, and there are plantation in many countries now.It is fickle in love
For yellow, petal is white, can highly grow to 60 centimetres.Yellow is presented in distillable essential oil color, the grass with point sweet tea sweet tea
Taste.Rome oil of chamomile of the present invention is preferably 0.5~1 parts by volume.
Spearmint blade crape and it is sharp, flower be purple, 90 centimeters of height can be grown to.The extraction position of oleum menthae viridis：The top bloomed
End, leaf；Extracting process：Distillation.Oleum menthae viridis of the present invention is preferably 0.5~1 parts by volume.
The present invention is for above-mentioned oil of grapefruit, tangerine oil, bergamot oil, marjoram oil, cassia oil, clove bud oil, hundred
In sesame oil, frankincense oil, lemon oil, attar of rose, orange oil, the permanent caul-fat of Italy, Clary Sage oil, Rome oil of chamomile and
The source of oleum menthae viridis is commercially available without limiting.
In a portion embodiment of the present invention, the compound essential oil composition includes the component of following volume parts：
Oil of grapefruit 2~3；Tangerine oil 2~4；Bergamot oil 1~2；Marjoram oil 0~2；Cassia oil 0~2；Cloves bud
Oil 0~2；Thyme linaloe oil 0~1；Frankincense oil 0~1；Lemon oil 0~3；Attar of rose 0~3；Orange oil 0~2；Italian permanent flower
Oil 0~3；Clary Sage oil 0~1；Rome oil of chamomile 0~1；Oleum menthae viridis 0~1.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Oil of grapefruit 3；Tangerine oil 2；Bergamot oil 1；Marjoram oil 2；Cassia oil 2；Clove bud oil 2；Thyme linaloe oil 1；
Frankincense oil 1；Lemon oil 2.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Oil of grapefruit 2；Tangerine oil 2；Bergamot oil 2；Attar of rose 3；Orange oil 2；Italian permanent caul-fat 3；Happy rat-tail
Careless oil 1；Rome oil of chamomile 1；Oleum menthae viridis 1；Marjoram oil 2.
In a portion preferred embodiment of the present invention, the compound essential oil composition includes the group of following volume parts
Point：
Oil of grapefruit 2；Tangerine oil 4；Bergamot oil 2；Orange oil 2；Attar of rose 2；Lemon oil 3.
The present inventor creatively has found, in the oil of grapefruit of the present invention of specific proportioning, the base of tangerine oil, bergamot oil
Coordinate marjoram oil, cassia oil, clove bud oil, thyme linaloe oil, frankincense oil, lemon oil, attar of rose, orange oil, meaning big on plinth
Three kinds or more in sharp permanent caul-fat, Clary Sage oil, Rome oil of chamomile and oleum menthae viridis；It preferably selects above-mentioned
Three kinds or more ten kinds or less carry out compatibility with oil of grapefruit, tangerine oil, bergamot oil and cooperate with, the compound essential oil being finally prepared
With significant collaboration antidepressant effect, and fragrance crowd acceptance is high.
In addition, the compound essential oil of the present invention is also equipped with following features：A is free of essence：Use the stoste of pure natural essential oil, generation
For artificial synthetic essence.Therefore matter is pure, mild, safety, fragrance is pleasant, does not stimulate, and has the effect of aromatotherapy.B does not add anti-
Rotten agent：Natural essential oil has the function of antibacterial, sterilization mostly, without adding preservative.C is free of mineral grease：It entirely uses natural
Plants essential oil.D is free of the chemical composition for causing allergy：Pure natural essential oil is entirely free of artificial essence, lanolin, alcohol, chemistry
Property sun-screening agent, pigment etc. can cause the ingredient of allergy, and to adding the raw material used each time, all it was proved that, to people
Body not will produce allergy.E flavor changes：Fragrance gradually changes as time went on, and different fragrance can be brought to people to differ
The experience and impression of sample allow people to generate different mood.F improves air quality：Natural essential oil mostly with antibacterial, sterilization work
With can improve air quality, air is made to keep fragrant freshness.G compound essential oils are safe in folk prescription essential oil：Compound essential oil
Significantly reduce in each folk prescription essential oil has certain toxicity and excitatory chemical composition to human body, such as phenols and aldoketones, improves
Terpenes and alcohols property safe to the human body are high, the no irritating chemical composition of sensitivity.
The preparation method of the present invention is directly to mix oil of grapefruit, tangerine oil, bergamot oil according to parts by volume, is
Method well known to those skilled in the art, the present invention is to this without limiting.
Or oil of grapefruit, tangerine oil, bergamot oil are coordinated into marjoram oil, cassia oil, clove bud oil, thyme
Oil, frankincense oil, lemon oil, attar of rose, orange oil, the permanent caul-fat of Italy, Clary Sage oil, Rome oil of chamomile and green thin
Three kinds or more in lotus oil is directly mixed according to parts by volume, is method well known to those skilled in the art, this hair
It is bright to this without limit.
The present invention provides the compositions described in a kind of above-mentioned technical proposal any one to prepare the product for alleviating depression
In application.
The present invention provides a kind of products for alleviating depression, including the composition described in above-mentioned technical proposal any one.
The product provided by the invention for alleviating depression is influenced by the active volatile ingredient in essential oil by olfactory system
Cerebral nervous system avoids the side effect that oral western medicine is brought to have effects that alleviate depression, safe to use and square
Just.
The application method of the product of the present invention for alleviating depression is specially to draw 100 μ L essential oil compositions to be added drop-wise to champignon
It is heated in box；It smells and inhales the time for 30min；The temperature for heating essential oil composition is 60 DEG C.
The present invention provides a kind of compound essential oil compositions, include the component of following volume parts：Oil of grapefruit 1~4；Mandarin orange
Mandarin oil 1~5；Bergamot oil 1~3.The present invention is by by the original of these pure natural essential oils of oil of grapefruit, tangerine oil and bergamot oil
Liquid carries out rational compatibility, and combines specific ratio so that the compound essential oil of gained has good collaboration antidepression
Effect, and fragrance crowd acceptance is high.In addition, the compound essential oil of the present invention without artificial synthetic essence, do not add preservative, no
Containing mineral grease, without the chemical composition for causing allergy, ingredient safety is not easy allergy.
In order to further illustrate the present invention, with reference to embodiments to a kind of compound essential oil combination provided by the present invention
The product of object, its application and alleviation depression is described in detail.
Examples 1 to 7；Comparative example 1~6
A kind of compound essential oil includes the component of volume parts as shown in the table.
In order to further prove that advantages of the present invention, the present invention provide the compliance test result of Examples 1 to 7 and comparative example 1~6
Data.
1. the antidepressant effect of Examples 1 to 7 and comparative example 1~6 is verified
The antidepression of Examples 1 to 7 and comparative example 1~6 is imitated using mouse forced swimming test test or mouse tail suspension test
Fruit is studied.
It is subjects to choose SPF grades of male mouse of kunming, mouse is randomly divided into 14 groups, every group 10, adaptability is fed
After supporting 3 days, mouse is put into carry out hearing perfume in 600*400*200mm crispers respectively, wherein 1 group is blank control group, be put into
100 μ L distilled water；2~8 groups are Examples 1 to 7 group, are put into the compound essential oil described in 100 μ L Examples 1 to 7；9~14 groups are
1~6 group of comparative example is put into the essential oil described in 100 μ L comparative examples 1~6.It is tested after hearing perfume 30min in the 4th day.
Hear fragrant mode：Distilled water and essential oil are added in fragrance box, are placed on mouse in the crisper in normal ventilation hole and contact
Less than place, mouse is put into crisper, 60 DEG C of heating fragrance boxes make distilled water and essential oil volatilize, and news smells 30min.Experiment
The free feeding of period mouse and drinking-water.
Mouse forced swimming test is tested or mouse tail suspension test
Forced swimming tests (FST)
Every mouse is individually put into the cylindrical glass water vat of high 30cm, diameter 18cm, depth of water 10cm, water temperature
23±2℃.Mouse into the water after first adapt it to swimming 2min, it is accumulative not then to record in following 4min mouse swimming
The dynamic time.The criterion of the motionless state of mouse is：Mouse stops struggling on the water surface in static floating state four limbs, or only
Have small maintaining the limb action of balance to be shown as disappointed state.
Outstanding tail test (TST)
Mouse forced swimming test test terminates to carry out outstanding tail test afterwards for 24 hours.The medical adhesive tape for being stained with hook is sticked to away from mouse
At tail point 1cm, hanging over makes its immovable position on the hole of rack cross-bar, and mouse is in projecting state, head distance black
Desktop about 5cm hangs a mouse every time.It first allows mouse to adapt to handstand posture 2min after suspension, then records following 4min
Interior outstanding tail adds up the dead time.The criterion of motionless state is：Mouse is projecting stop shaking struggle or keep a kind of posture without
Other actions are shown as disappointed state.
Test result data is indicated using average ± standard deviation, and uses the difference between variance analysis method comparative group.
Influence of the difference group essential oil to the mouse forced swimming test dead time
| Group | Non-swimming time (s) | The outstanding tail dead time (s) |
| Blank control group | 158.4±1.10 | 132.9±0.89 |
| 1 group of embodiment | 95.0±0.66*g | 80.7±1.18*e |
| 2 groups of embodiment | 92.2±1.01*h | 78.8±1.06*f |
| 3 groups of embodiment | 84.0±0.64*k | 66.8±0.80*j |
| 4 groups of embodiment | 82.1±1.09*l | 63.8±1.08*k |
| 5 groups of embodiment | 85.9±1.07*j | 69.3±1.18*i |
| 6 groups of embodiment | 88.8±1.08*i | 73.7±1.33*h |
| 7 groups of embodiment | 89.4±0.72*i | 76.9±1.14*g |
| 1 group of comparative example | 103.9±0.78*d | 86.8±1.06*d |
| 2 groups of comparative example | 101.8±1.06*e | 89.6±1.29*c |
| 3 groups of comparative example | 112.9±0.99*b | 90.8±1.01*b |
| 4 groups of comparative example | 100.3±1.13*f | 87.4±1.18*d |
| 5 groups of comparative example | 108.5±0.72*c | 92.7±0.91*a |
| 6 groups of comparative example | 123.4±0.96*a | 88.7±1.33*c |
Note：Shoulder mark * indicates embodiment, comparative example each group compared with blank control group with significant difference, P ＜ 0.05；
Same column shoulder marking-up female (a, b, c, d, e, f, g, h, i, j, k, l) indicates to be compared between embodiment and comparative example difference group, indicates
Different letters indicate there is significant difference, P ＜ 0.05
By above-mentioned experiment it is found that 1~6 group of Examples 1 to 7 group and comparative example are compared with blank control group, the swimming of mouse
Dead time and outstanding tail dead time decrease, and have significant difference (P ＜ 0.05), show Examples 1 to 7 with it is right
The essential oil of ratio 1~6 all has certain antidepressant effect.The comparison among groups result of 1~6 group of Examples 1 to 7 group and comparative example
The non-swimming time and outstanding tail dead time for showing Examples 1 to 7 group are significantly shorter than 1~6 group of comparative example, wherein effect most
Excellent is 4 groups of embodiment.As a result it prompts, is combined in certain proportion between oil of grapefruit, tangerine oil and bergamot oil, it can be with
Play synergistic function, obtain preferable antidepressant effect, and further add marjoram oil, cassia oil, clove bud oil,
Thyme linaloe oil, frankincense oil, lemon oil, attar of rose, tangerine oil, the permanent caul-fat of Italy, Clary Sage oil, Rome chamomile
It is one or more in oil, oleum menthae viridis, the effect of composition can be further increased.
2. fragrance crowd's acceptance of Examples 1 to 7 and comparative example 1~6 is investigated
Please 50 experienced professionals form evaluation groups, to the essential oil described in Examples 1 to 7 and comparative example 1~6
Fragrance is evaluated, and evaluation result is as follows：
Acceptance demographics of the crowd to different essential oil fragrance
Acceptance proportion of the crowd to different essential oil fragrance
| Group | It is satisfied | Generally | It is dissatisfied |
| 1 group of embodiment | 80.0% | 18.0% | 2.0% |
| 2 groups of embodiment | 84.0% | 14.0% | 2.0% |
| 3 groups of embodiment | 88.0% | 12.0% | 0.0% |
| 4 groups of embodiment | 92.0% | 8.0% | 0.0% |
| 5 groups of embodiment | 86.0% | 14.0% | 0.0% |
| 6 groups of embodiment | 84.0% | 14.0% | 2.0% |
| 7 groups of embodiment | 80.0% | 16.0% | 4.0% |
| 1 group of comparative example | 78.0% | 16.0% | 6.0% |
| 2 groups of comparative example | 70.0% | 22.0% | 8.0% |
| 3 groups of comparative example | 76.0% | 18.0% | 6.0% |
| 4 groups of comparative example | 74.0% | 16.0% | 10.0% |
| 5 groups of comparative example | 72.0% | 20.0% | 8.0% |
| 6 groups of comparative example | 78.0% | 14.0% | 8.0% |
Above-mentioned test result shows acceptance of the crowd to different essential oil fragrance, from dissatisfaction it can be seen that embodiment
Dissatisfaction is below comparative example, it can be seen that, the fragrance acceptance of each embodiment is above comparative example.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of compound essential oil composition, includes the component of following volume parts：
Oil of grapefruit 1~4；
Tangerine oil 1~5；
Bergamot oil 1~3.
2. composition according to claim 1, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Oil of grapefruit 2~4；
Tangerine oil 2~4；
Bergamot oil 1~2.
3. composition according to claim 1, which is characterized in that the compound essential oil composition further includes following any one
The component of kind or several volume parts：
4. composition according to claim 3, which is characterized in that the compound essential oil composition further includes following any one
The component of kind or several volume parts：
5. composition according to claim 3, which is characterized in that the compound essential oil composition includes following volume parts
Component：
6. composition according to claim 5, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Oil of grapefruit 3；Tangerine oil 2；Bergamot oil 1；Marjoram oil 2；Cassia oil 2；Clove bud oil 2；Thyme linaloe oil 1；Frankincense
Oil 1；Lemon oil 2.
7. composition according to claim 5, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Oil of grapefruit 2；Tangerine oil 2；Bergamot oil 2；Attar of rose 3；Orange oil 2；Italian permanent caul-fat 3；Clary Sage oil
1；Rome oil of chamomile 1；Oleum menthae viridis 1；Marjoram oil 2.
8. composition according to claim 5, which is characterized in that the compound essential oil composition includes following volume parts
Component：
Oil of grapefruit 2；Tangerine oil 4；Bergamot oil 2；Orange oil 2；Attar of rose 2；Lemon oil 3.
9. application of the composition in preparing the product for alleviating depression described in claim 1~8 any one.
10. a kind of product for alleviating depression, which is characterized in that including the composition described in claim 1~8 any one.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432318A (en) * | 2018-12-14 | 2019-03-08 | 北京斯利安药业有限公司 | Compound essential oil, its application and compound essential oil product |
| CN113058022A (en) * | 2021-04-23 | 2021-07-02 | 花安堂生物科技集团有限公司 | Composition and antidepressant product containing tangerine extract |
| CN113117040A (en) * | 2021-04-23 | 2021-07-16 | 花安堂生物科技集团有限公司 | Composition and antidepressant product containing magnolia sieboldii extract |
| CN114377055A (en) * | 2020-10-22 | 2022-04-22 | 植享家股份有限公司 | Compound essential oil composition and application thereof in preparing medicine for improving cognition, sleep and emotion |
-
2018
- 2018-05-16 CN CN201810468707.3A patent/CN108452060B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109432318A (en) * | 2018-12-14 | 2019-03-08 | 北京斯利安药业有限公司 | Compound essential oil, its application and compound essential oil product |
| CN109432318B (en) * | 2018-12-14 | 2021-07-13 | 北京斯利安药业有限公司 | Compound essential oil, application thereof and compound essential oil product |
| CN114377055A (en) * | 2020-10-22 | 2022-04-22 | 植享家股份有限公司 | Compound essential oil composition and application thereof in preparing medicine for improving cognition, sleep and emotion |
| CN113058022A (en) * | 2021-04-23 | 2021-07-02 | 花安堂生物科技集团有限公司 | Composition and antidepressant product containing tangerine extract |
| CN113117040A (en) * | 2021-04-23 | 2021-07-16 | 花安堂生物科技集团有限公司 | Composition and antidepressant product containing magnolia sieboldii extract |
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