CN113456694A

CN113456694A - Combined formula of fragrant essential oil for promoting sleep

Info

Publication number: CN113456694A
Application number: CN202110975669.2A
Authority: CN
Inventors: 赵才添
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-08-24
Filing date: 2021-08-24
Publication date: 2021-10-01

Abstract

The invention relates to the field of medicines, and in particular relates to a combined formula of fragrant fumigating essential oil for promoting sleep, which comprises the following components in parts by weight: 4.5-8 parts of lavender oil, 2-5 parts of geranium oil and 0.5-2.2 parts of sandalwood oil; also comprises 1.5 to 2.8 parts of bergamot fruit oil and 0.4 to 3.3 parts of vetiver root oil; also comprises 0.5 to 2.6 parts of rose oil, 0.5 to 2.6 parts of eucalyptus globulus leaf oil, 0.3 to 2.2 parts of frankincense oil and 0.2 to 1.8 parts of manuka oil. The formula of the invention has small side effect and convenient use, and can play the roles of tranquilizing, hypnotizing, relaxing nerves and the like.

Description

Combined formula of fragrant essential oil for promoting sleep

Technical Field

The invention relates to the field of medicines, and in particular relates to a combined formula of fragrant essential oil for promoting sleep.

Background

Sleep is an important physiological process for maintaining the normal function and operation of each organ of the body, and is consistently considered as a resting state of the body of higher animals, particularly higher spine animals, which alternate with each other according to their own specific biological rhythms and wakefulness states. However, various interference factors inside or outside the human body easily cause sleep disorder and malfunction of the arousal mechanism. This dysbiosis can cause a series of clinical symptoms related to the sleep and wakefulness states, i.e. sleep disorders, which are mainly manifested by insufficient or excessive sleep.

The common medicines for clinically treating the sleep disorder comprise sedative hypnotics, antidepressants with hypnotic effect, traditional Chinese medicines and the like. The medicine has the effect of promoting sleep of human bodies clinically, but the medicine treatment is not preferred for patients with special sleep disorder, such as the elderly. For the elderly, the medicines for promoting sleep have more adverse reactions after being taken. The patient is very easy to have the adverse reactions of ataxia, abnormal movement, sleepwalking, respiratory depression and the like, the muscle tension of the patient is easily reduced if the patient is in a light state, the patient easily falls down, and the life of the patient is threatened if the patient is in a heavy state. For treating the sleep disorder patients, most western medicines have limited curative effect, are easy to generate drug resistance and are easy to generate adverse reactions, such as nausea, vomiting, dizziness, headache and the like. Therefore, there is a need in the art to develop new methods for treating sleep disorders.

Disclosure of Invention

The invention aims to provide a combination formula of fragrant essential oil for promoting sleep, which has small side effect and convenient use and can play the roles of calming, hypnotizing, relaxing nerves and the like.

A combined formula of fragrant fumigating essential oil for promoting sleep comprises the following components in parts by weight: 4.5-8 parts of lavender oil, 2-5 parts of geranium oil and 0.5-2.2 parts of sandalwood oil.

Further, the feed also comprises the following components in parts by weight: 1.5-2.8 parts of bergamot fruit oil and 0.4-3.3 parts of vetiver root oil.

Further, the feed also comprises the following components in parts by weight: 0.5-2.6 parts of rose oil, 0.5-2.6 parts of eucalyptus globulus leaf oil, 0.3-2.2 parts of frankincense oil and 0.2-1.8 parts of manuka oil.

The effects of the raw materials in the invention are as follows:

lavender oil: it has lavender fragrance with spicy fragrance. Has antibacterial, disinfectant, refreshing, tranquilizing, and antifatigue effects.

Geranium oil: has inhibitory effect on some fungi, and has antibacterial and acarid removing effects; has certain effect of eliminating some free radicals and certain oxidation resistance.

Sandalwood oil: it has effects of keeping moisture and removing wrinkle, and can relieve skin, and its glycosides can clean skin deep layer. The extract of the tree with gold is also called "liquid gold", and the extracted oil is mainly used as a softening agent.

Bergamot fruit oil: has anti-inflammatory effect; the activation of cathepsin shows that it can enhance the metabolism of skin and has the function of anti-aging.

Vetiver root oil: can improve the fragrance of the product, condition greasy skin, improve damaged skin and maintain the health state of skin.

Rose oil: the rose oil is a natural perfume extracted from roses, is one of precious essential oils, and has the characteristics of nature, pure fragrance and the like. It also has free radical scavenging effect, and can be used as antioxidant for preventing aging; can enhance cell activity and has skin activating effect; has certain inhibition effect on tyrosinase, and can assist in whitening.

Eucalyptus globulus oil: the eucalyptus globulus oil contains rich antibacterial and antiseptic components, and can effectively inhibit acne bacteria; has effects in inhibiting histamine and resisting allergy; can promote keratinocyte proliferation, and has effects of scavenging free radicals, and preventing aging; and can also be used as odor inhibitor and humectant.

Butter oil: the frankincense oil has a good activation effect on a peroxidase-activated receptor, plays an important role in the healing process of skin injury, and shows that the frankincense oil has good anti-inflammation performance; can enhance lipase activity, is helpful for fat decomposition, and can be used in weight-reducing products or washing products for oily skin; promoting activation of caspase, prolonging cell life, and resisting aging; can promote the growth of hair, and is a good hair growth agent.

Manuka oil: has warm and calm fragrance, can relieve itching and irritation, and is a powerful antibacterial agent.

Lavender is a perennial herb of Labiatae in the genus of Perilla, and comprises essential oil, tannin, coumarin, flavonoid, polyphenol, etc. Because of different chemical components in the lavender essential oil, the lavender essential oil has different effects, some have the effects of soothing the nerves and helping sleep, some have the effects of refreshing mind, some have the effects of moistening the skin, some have no effect, and some have toxicity. Researchers have studied the anxiolytic effect of lavender fragrance on Mongolian gerbils, and the conclusion is that the lavender fragrance has similar anxiolytic effect with the tranquilizer. Even if the chemical components in the lavender essential oil are complex, the overall anti-restlessness and sedative effects are undoubted. The invention also adds pelargonium roseum oil and sandalwood oil, and the pelargonium roseum oil, the sandalwood oil and the lavender oil can play the active effects of sedation and hypnosis. The combination of the three can better play the effects of calming nerves and helping sleep, and the volatilization of different chemical components enters the body through the olfactory system to induce the organism to secrete hydroxytryptamine, so that people can sleep quickly, the inhibitory neurotransmitter serotonin, 5-hydroxytryptamine can be further converted into melatonin in the human body, and the melatonin is proved to have definite functions of calming and inducing sleep.

The bergamot fruit oil mainly plays a role of a softening agent, has an anti-inflammatory effect, enhances the metabolism of skin, improves the sleep quality and simultaneously plays an anti-aging effect on the main hypnotic effect of the three components. The vetiver oil, the rose oil, the eucalyptus globulus leaf oil, the frankincense oil and the manuka oil are used as auxiliary agents, have multiple functions while keeping the lasting fragrance emitted by the essential oil, supplement nutrition for human skin and various parts of the body, and assist the human body in expelling toxin, discharging waste and stabilizing the nervous system.

The formula of the invention is an aromatherapy essential oil formula of traditional Chinese medicine aromatherapy, which is convenient to use and can be operated at home, and the effective components in the medicine formula are absorbed by olfactory organs or skin and are conveyed to internal organs of a human body along with blood and body fluid through modes of massage, fumigation and the like. According to the invention, the lavender oil, the geranium oil and the sandalwood oil are used as monarch drugs, and the three are matched as main components for sedation and hypnosis, so that the sleep disorder symptom is treated; the bergamot fruit oil is taken as a ministerial drug to assist the principal drug to further enhance the functional indication symptom; the vetiver oil, the rose oil, the eucalyptus globulus leaf oil, the frankincense oil and the manuka oil are used as adjuvants to assist main medicines in treating accompanying diseases, and have the effects of enhancing the efficacy, relieving nerves and the like.

The invention has the beneficial effects that: the invention provides an aromatherapy essential oil composition of a traditional Chinese medicine aromatherapy, which has small side effect and convenient use, can be operated at home, and can ensure that effective components in the composition are absorbed by olfactory organs or skins and are conveyed to internal organs of a human body along with blood and body fluid through modes of massage, fumigation and the like, so as to supplement nutrition for human body skin and various parts of the human body, assist the human body in expelling toxin, discharging wastes and stabilizing nervous system, promote the coordination and balance of the body and the mind, enhance the function of the immune system, achieve the effects of promoting sleep, improving skin and adjusting physique, and further play a role in preventing and treating diseases.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments in order to make the above objects, features and advantages more apparent and understandable. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

(1) The embodiment provides a combined formula of fragrant fumigating essential oil for promoting sleep, which comprises the following components in parts by weight: 4.5 parts of lavender oil, 2 parts of geranium oil and 0.5 part of sandalwood oil.

Further, the essential oil can be used after being mixed and uniformly stirred, and the essential oil can be prepared by subcritical fluid extraction, organic solvent extraction, steam distillation or squeezing.

Further, it can be administered by incense, hot water steam, handkerchief, friction with palm, spray, or patch.

The essential oil prepared by the formula of the invention mainly permeates into the body in an olfactory way, and the specific use mode is as follows:

incense type

S1, selecting a incense stand made of ceramic for standby;

s2, pouring boiled water or purified water into a basin above the incense stand, and placing the basin into 4/5 of the volume of the incense stand;

s3, dropping the compound essential oil into a basin, and dropping 9-12 drops in total.

The compound essential oil of the embodiment can also be directly dripped into the dried flowers by adopting a fumigating type.

Two, hot water steam type

The boiled hot water is poured into a glass, ceramic or stainless steel cup, 5-8 drops of the compound essential oil in the example are dripped into the cup, a large towel or clothes is used for covering the back neck, the cup is stood over the mouth of the cup, and the mouth and the nose are alternately breathed until the cup is comfortable.

Three, handkerchief type

5-10 drops of the composite refined oil in the embodiment are dropped on facial tissue or handkerchief and can be used before sleep.

Four, palm friction type

Before sleep, 2-3 drops of the compound essential oil in the example are rubbed by hands to generate heat, and the effect of tranquilizing and allaying excitement can be achieved.

Spray type

Adding 10-25 of the compound essential oil in the example into 100ml of purified water, uniformly shaking, directly spraying the mixture on a human body, and spraying the mixture from the upper part at 45 ℃ to the lower part, wherein the following steps are carried out in sequence:

a1, sitting on a bed before sleeping, closing eyes and relaxing mood;

a2, spraying the compound essential oil from the top of the head to make the mist slowly fall to the head;

a3, spraying the essential oil onto other parts such as hair and face when smelling.

Sixthly, patch type

B1, preparing a patch, mixing the essential oil of the aromatherapy and a thickening matrix (carbomer, HPMC, PVA, PEG, cetyl alcohol or propylene glycol and the like) in equal volume, heating while stirring until a viscous semi-solid fluid is obtained, coating the semi-solid fluid on an aluminum foil backing layer, cooling to be solidified at room temperature, covering an EVA film and an adhesive layer, and performing heat sealing to obtain a patch preparation;

b2, the patch is stuck on the forehead, the Yintang acupoint or other parts of the body 1 hour before falling asleep every day, and the using parts are changed every day;

b3, using 1 patch each time, the patient with severe sleep disorder can use 2 patches each time in the previous week, and can reduce the dosage to 1 patch each time according to the use condition.

The six modes can be selected according to actual conditions, the spray mode is preferred in the embodiment, the method is simple, and the operation is convenient.

Examples 2 to 5

The main differences between examples 2-5 and example 1 are shown in table 1 below:

table 1 examples 1-5

Examples 6 to 8, comparative example 1 and comparative example 2

Example 6 also included 1.5 parts bergamot fruit oil and 3.3 parts vetiver root oil, compared to example 3.

Example 7 also includes 2 parts bergamot fruit oil and 2 parts vetiver root oil, compared to example 3.

Compared with example 3, example 8 further includes 2.8 parts of bergamot fruit oil and 3.3 parts of vetiver root oil.

Comparative example 1 also included 2 parts bergamot fruit oil, compared to example 3.

Comparative example 1 also included 2 parts of vetiver oil, compared to example 3.

Examples 6-8, comparative example 1 and comparative example 2 were prepared and used in the same manner as example 1.

Examples 6-8, comparative example 1 and comparative example 2 differ from example 3 mainly as shown in table 2 below.

TABLE 2 examples 3, 6-8 and comparative examples 1-2

Examples 9 to 11, comparative example 3 and comparative example 4

Example 9 also includes 0.5 parts rose oil and 0.5 parts eucalyptus globulus oil, compared to example 8.

Example 10 also includes 1.5 parts rose oil and 1.5 parts eucalyptus globulus oil, compared to example 8.

Example 11 also included 2.6 parts rose oil and 2.6 parts eucalyptus globulus oil as compared to example 8.

Comparative example 3 also included 1.5 parts rose oil as compared to example 8.

Comparative example 4 also included 1.5 parts eucalyptus globulus oil as compared to example 8.

Examples 9-11, comparative example 3 and comparative example 4 were prepared and used in the same manner as example 1.

Examples 9-11, comparative example 3 and comparative example 4 differ from example 8 mainly as shown in table 3 below.

TABLE 3 examples 8, 9-11 and comparative examples 3-4

Examples 12 to 14, comparative example 5 and comparative example 6

Example 12 also included mastic oil 0.3 parts and manuka oil 0.2 parts compared to example 11.

Example 13 also included mastic oil 1.6 parts and manuka oil 1 part as compared to example 11.

Example 14 also includes 2.6 parts of mastic oil and 2.6 parts of manuka oil, compared to example 11.

Comparative example 5 also included 2.6 parts of mastic oil, compared to example 11.

Comparative example 6 also included manuka oil 2.6 parts compared to example 11.

Examples 12-14, comparative example 5 and comparative example 6 were prepared and used in the same manner as example 1.

Examples 12-14, comparative example 5 and comparative example 6 differ from example 11 mainly as shown in table 4 below.

TABLE 4 examples 11, 12-14 and comparative examples 5-6

Comparative example 7

The clothes for promoting sleep disclosed in the invention patent with publication number CN106723432A are used as a comparative example 7, and the comparative example 7 comprises 20 parts of rosemary oil, 20 parts of cabbage flower oil, 25 parts of rose oil, 8 parts of geranium oil, 3 parts of sweet osmanthus oil, 7 parts of lavender oil, 13 parts of peppermint oil, 18 parts of borneol oil, 19 parts of cedar wood oil, 24 parts of valerian oil, 5 parts of sandalwood oil, 6 parts of geranium oil, 12 parts of fortune eupatorium herb and 24 parts of orange essential oil. The preparation method of the clothes comprises the following steps: manufacturing the textile material into a garment; grafting the microcapsule on the fabric by a surface modification method and a thermal fixing method; encapsulating a hypnotic essential oil composition in said microcapsules; the microcapsules are made into shells with chitosan walls by a coacervation process.

Experiment one: establishing rat sleep disorder model

Twenty two groups of healthy SD rats, five in each group, were fed, and after two weeks of normal feeding, except for the blank group, rats in each group were intraperitoneally injected with an equal amount of a PCPA (p-chlorophenylalanine) suspension dissolved in physiological saline (PCPA is an inhibitor of tryptophan hydroxylase (TDH), and TDH is a rate-limiting enzyme of sleep-promoting neurotransmitter 5-HT, so that PCPA is deprived of sleep by blocking 5-HT) at a concentration of 400mg kg¹The rats in the blank group are injected with the same volume of weak alkaline physiological saline in the abdominal cavity for 2 days continuously, after the rats are injected for 25-32 hours for the first time, the rats have circadian rhythm loss, and continuously move in the daytime and at night, and the average sleep latency and the sleep duration of the blank group and the model building group are recorded. Comparison of the blank group at the end of the modeling and the sodium pentobarbital righting experiment for PCPA is shown in table 5 below:

TABLE 5 comparison of blank groups at end of modeling and sodium pentobarbital correction experiments for PCPA

And (3) modeling conclusion: according to statistics of mouse sleep disorder modeling data, compared with a blank group, the average sleep latency of the PCPA group is prolonged, the average sleep time is shortened, and the PCPA group in the experiment successfully induces the rats to suffer from the sleep disorder.

Experiment two: grouping and incense treatment method

Each set of PCPAs was labeled as examples 1-14, comparative examples 1-7, and blank was labeled as blank. The essential oil formulas prepared by respectively adopting the essential oil formulas 1 to 14 in the embodiments 1 to 14 are mixed and then sprayed on each part of the body of a rat in equal quantity, the essential oil formulas prepared by the comparative examples 1 to 7 are mixed and then sprayed on each part of the body of the rat in equal quantity, the essential oil formulas are sprayed once every 2 hours and 3 times every day, and the fragrance is ensured to be performed for 8 hours every day and continuously for 7 days; the blank group was normally bred without spraying the essential oil. The sleep latency and the sleep duration of each group were recorded daily, and the comparison of the sodium pentobarbital straightening experiments of the examples 1-14 groups, the comparative examples 1-7 groups and the blank group at the end of the experiment is shown in the following tables 6 and 7 (wherein, table 6 is a statistical table of the sleep latency of each group of rats per day; table 7 is a statistical table of the sleep duration of each group of rats per day):

TABLE 6 statistical table of daily sleep latency of rats in each group

TABLE 7 statistical table of daily sleep duration for each group of rats

Note that: the standard deviation is not described here when statistical data is made.

And (4) conclusion:

in examples 1 to 14 and comparative examples 1 to 7, the sleep latency on days 1 to 4 decreased overall, and the sleep duration increased, but both fluctuated. The sleep latency and the sleep duration both stabilized by days 5-7. Therefore, the essential oil of the incense really plays a role in tranquilizing and allaying excitement. Specific analyses for examples 1-14 are as follows:

(1) in examples 1-5, the essential oil of incense of example 3 induced sleep more strongly, the whole sleep latency was the shortest, the whole sleep duration was the longest, and the latent sleep time of rats from day 1 to day 7 was shortened by 24.6%, and the average sleep duration was prolonged by 44.2%.

(2) In examples 6 to 8, the essential oil of incense of example 8 induced sleep more strongly, had the shortest overall sleep latency and the longest overall sleep duration, and the latent sleep time of rats from day 1 to day 7 was shortened by 21.9% and the average sleep duration was prolonged by 38.8%.

(3) In examples 9 to 11, the essential oil of incense of example 10 induced sleep more strongly, the whole sleep latency was the shortest, the whole sleep duration was the longest, and the latent sleep time of rats from day 1 to day 7 was shortened by 19.1%, and the average sleep duration was prolonged by 26.3%.

(4) In examples 12 to 14, the essential oil of incense of example 14 induced sleep more strongly, the whole sleep latency was the shortest, the whole sleep duration was the longest, and the latent sleep time of rats from day 1 to day 7 was shortened by 35.1%, and the average sleep duration was prolonged by 23.5%.

(5) In example 3, example 8, example 10 and example 14, the overall sleep latency and the consolidated sleep duration of example 14 fluctuated the most compared to the end of modeling, and after the 7-day experiment, the rats in the example 14 group slept better than the blank group.

Experiment three: the effect of inhaling the essential oil of the present invention on the primary sleep disorder patient was observed.

The formula of the embodiment 14 of the invention is applied to clinical experiments

The method comprises the following steps:

s1, selecting 75 testees from neurology inpatients at affiliated hospitals of medical university of Anhui, randomly dividing the testees into 5 groups, and dividing the groups into the essential oil for aromatherapy prepared by the formula in the embodiment 14 of the invention, wherein the method specifically comprises the following steps: 100% essential oil, 30% essential oil, 1% essential oil, grape seed oil and blank group;

s2, respectively inhaling the same amount of the above substances in the first 4 groups before sleep, continuously observing and recording data for one week every 10min, and performing no treatment on blank groups;

s3, adopting Polysomnography (PSG) results to discuss the curative effect of the medicine on insomnia and screen out proper concentration.

As a result: after one week of inhalation of the essential oil of the present invention, the PSG results showed that it could shorten sleep latency, prolong sleep time, improve sleep efficiency and sleep maintenance rate, increase (S3+ S4) and non-snap eye-arouse sleep percentage, lower blood pressure. Wherein, the difference between the 30 percent concentration essential oil group and the blank group has statistical significance, and the indexes are not obviously changed when the grape seed oil is absorbed.

And (4) conclusion: the essential oil can safely and effectively improve the insomnia of patients with primary insomnia by inhalation through olfactory pathway, wherein the effect of 30 percent concentration is better, and the grape seed oil has no function of improving sleep.

The above-mentioned embodiments are further described in detail for the purpose of illustrating the invention, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the invention and are not intended to limit the invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit of the invention should be included in the scope of the invention.

Claims

1. The formula of the essential oil composition for promoting sleep is characterized by comprising the following components in parts by weight: 4.5-8 parts of lavender oil, 2-5 parts of geranium oil and 0.5-2.2 parts of sandalwood oil.

2. The sleep-promoting aromatic essential oil combination formula according to claim 1, characterized by further comprising the following components in parts by weight: 1.5-2.8 parts of bergamot fruit oil and 0.4-3.3 parts of vetiver root oil.

3. The sleep-promoting aromatic essential oil combination formula according to claim 2, characterized by further comprising the following components in parts by weight: 0.5-2.6 parts of rose oil, 0.5-2.6 parts of eucalyptus globulus leaf oil, 0.3-2.2 parts of frankincense oil and 0.2-1.8 parts of manuka oil.

4. The sleep-improving aromatic essential oil combination formula according to any one of claims 1 to 3, wherein the preparation method comprises mixing the essential oils and stirring the mixture uniformly.

5. The sleep-promoting essential oil composition according to claim 4, wherein the composition is administered in a form of incense, hot water vapor, handkerchief, friction on the palm, spray or patch.