CN112121095A - Hypnotic essential oil composition with quick response and preparation method thereof - Google Patents

Hypnotic essential oil composition with quick response and preparation method thereof Download PDF

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CN112121095A
CN112121095A CN202010835758.2A CN202010835758A CN112121095A CN 112121095 A CN112121095 A CN 112121095A CN 202010835758 A CN202010835758 A CN 202010835758A CN 112121095 A CN112121095 A CN 112121095A
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extraction
hypnotic
essential oil
oil composition
preparing
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罗永东
周晴晴
毛建明
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Gmanli Suzhou Health Industry Development Co ltd
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Gmanli Suzhou Health Industry Development Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

Abstract

The invention relates to a preparation method of a hypnotic essential oil composition with quick response, which is characterized by comprising the following steps: s1, preparing lavender; s2 preparing cananga odorata; s3 preparing cypress; s4, preparing lemons; s5, mixing the lavender, the cananga odorata, the cedar and the lemon prepared in the S1-S4 according to the proportion of 5:2:2:1 to prepare a mixture; s6, recombining the mixture in S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition, wherein the components in the composition are extracted by a carbon dioxide supercritical method respectively, and are mixed in proportion and then recombined by molecular distillation, so that the obtained product has the characteristics of dark color, rich fragrance, less impurity content and easiness in quantification, and the volatility and the easiness in transdermal absorption of the recombined essential oil are utilized, the sedative-hypnotic effect with quick response is achieved by nasal feeding inhalation or skin acupoint administration, and the sedative-hypnotic composition is safe, non-toxic and controllable in quality and can better play the sedative-hypnotic effect.

Description

Hypnotic essential oil composition with quick response and preparation method thereof
Technical Field
The invention relates to an essential oil composition, in particular to a hypnotic essential oil composition with quick response and a preparation method thereof.
Background
Insomnia is a sleep disorder caused by sleep disruption or decreased sleep time, and is mainly characterized by insufficient sleep time and sleep depth. According to expert estimation, there are about 7 hundred million insomnia people worldwide by 2020. A large number of insomnia patients are accompanied by depression and anxiety symptoms of different degrees, so that the mental activity efficiency of the patients is reduced, the immune function of the patients is reduced, the vegetative nerve function is disordered, and the risks of diabetes, coronary heart disease, senile dementia and the like are increased.
The medicaments for treating insomnia commonly comprise benzodiazepines, non-benzodiazepines, antidepressant with sedative effect and the like, and are easy to generate various adverse reactions such as dependence, tolerance, withdrawal symptoms, rebound action and the like after long-term use. People are expected to achieve the treatment purposes of higher safety and less adverse reactions through natural plants for a long time, and more scholars are keen to search for new and safe adjuvant or alternative therapies for treating insomnia. Researches show that the aromatic plant essential oil has good sedative hypnotic effect through the inhalation therapy, has strong safety compared with oral drugs, and can avoid the daytime hangover, eliminate the first pass and stimulate the gastrointestinal tract.
The agilawood essential oil, the ligusticum wallichii essential oil and the eupatorium fortunei essential oil have the effects of calming and hypnotizing after inhalation, and can obviously reduce the autonomous activity of animals, shorten the sleep latency and prolong the sleep time. In the aspect of related research of the compound essential oil, the compound essential oil prepared by blending the origanum vulgaris essential oil, the German chamomile essential oil and the lavender essential oil and the compound essential oil prepared by taking the L-linalool as the main raw material have the effect of improving sleep.
The plant essential oil has various extraction methods, and each method has advantages and disadvantages and an application range, compared with the traditional methods such as steam distillation, the carbon dioxide supercritical extraction (SFE) method has the advantages of thermal stability, no solvent residue, high efficiency, less energy consumption and the like, and the obtained product has high purity, good activity, safety, less impurities and easier quality control.
The plant essential oil can be applied in a single formula or a compound formula, and is applied in a compound formula, for example, in cosmetics, some base oil is usually used for increasing the stability of crude oil, and the physiological activity of the compound essential oil is generally considered to be better than that of the single formula; however, the essential oil components are complex, different varieties of essential oils are mixed and compounded, the quality of the obtained mixture is difficult to control due to the fact that chemical components are too complex besides the compatibility of physical properties, and at present, no hypnotic essential oil composition with good quality and compatibility can be compounded.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a hypnotic essential oil composition with quick response, wherein the components in the composition are respectively extracted by a carbon dioxide supercritical method, and are mixed in proportion and then recombined by molecular distillation, and the obtained product has the advantages of dark appearance color, rich fragrance, low impurity content and easiness in quantification. The volatile property and the easy transdermal absorption of the recombinant essential oil are utilized, the sedative-hypnotic effect with quick effect is achieved by nasal feeding inhalation or skin acupoint administration, and the sedative-hypnotic composition is safe, non-toxic and controllable in quality and can better play the sedative-hypnotic effect.
In order to achieve the purpose, the invention adopts the technical scheme that: a method for preparing a fast-acting hypnotic essential oil composition comprises the following steps:
s1 lavender preparation: naturally drying, pulverizing, sieving, and extracting Lavender with supercritical extraction device;
s2 preparation of ylang: freeze drying, pulverizing, sieving, and extracting with supercritical extraction device;
s3 preparation of cedar: naturally drying, pulverizing, sieving, and extracting cypress with supercritical extraction device;
s4 preparing lemon: drying the raw materials, controlling the water content to be less than 10%, crushing and sieving for later use, and extracting the cedar by using a supercritical extraction device;
s5 mixing lavender, cananga odorata, cedar and lemon prepared in S1-S4 according to the proportion of 5:2:2:1 to prepare a mixture;
s6 recombining the mixture in S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition.
Further, the extraction environment of the supercritical extraction apparatus in S1 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22Flow rate of 22-30L/h, extraction time of 2-3h, and temperature30-40 ℃, and the pressure of the extraction kettle is 10-20 MPa.
Further, the extraction environment of the supercritical extraction apparatus in S2 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 10-25L/h, the extraction time is 2-3h, the temperature is 35-50 ℃, and the pressure of the extraction kettle is 10-20 MPa.
Further, the extraction environment of the supercritical extraction apparatus in S3 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 1-5L/h, the extraction time is 3-5h, the temperature is 70 ℃, and the pressure of the extraction kettle is 10-20 MPa.
Further, the extraction environment of the supercritical extraction apparatus in S4 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 0.1-2L/h, the extraction time is 6-7h, the temperature is 50 ℃, and the pressure of the extraction kettle is 10-20 MPa.
Further, the distillation environment of the molecular distillation is as follows: the feeding speed is 0.5-2 mL/min, the molecular distillation temperature is 30-60 ℃, the film scraping rotation speed is 200-300 r/min, and the distillation pressure is 30-50 Pa.
The hypnotic essential oil composition with the rapid effect is prepared by mixing and compounding lavender, cananga odorata, cedar and lemon according to the proportion of 5:2:2:1, and recombining through molecular distillation.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
according to the hypnotic essential oil composition with the rapid effect, the components contained in the composition are extracted by a carbon dioxide supercritical method respectively, and are mixed in proportion and then recombined by molecular distillation, the obtained product has dark color and strong fragrance, is low in impurity content and easy to quantify, and by utilizing the characteristics of volatility and easiness in transdermal absorption of the recombined essential oil, the sedative-hypnotic effect with the rapid effect is achieved by nasal feeding inhalation or skin acupoint administration, and the sedative-hypnotic essential oil composition is safe, non-toxic, controllable in quality and capable of better playing the sedative-hypnotic effect.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
Example one
A method for preparing a fast-acting hypnotic essential oil composition comprises the following steps:
s1 lavender preparation: naturally air-drying, crushing and sieving for later use, and extracting the lavender by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 22L/h, the extraction time is 2h, the temperature is 30 ℃, and the pressure of the extraction kettle is 10 MPa.
S2 preparation of ylang: freeze-drying, crushing and sieving for later use, and extracting cananga odorata by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 10L/h, the extraction time is 2h, the temperature is 35 ℃, and the pressure of the extraction kettle is 12 MPa.
S3 preparation of cedar: naturally air-drying, crushing and sieving for later use, and extracting cypress by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 1L/h, the extraction time is 3h, the temperature is 70 ℃, and the pressure of an extraction kettle is 13 MPa.
S4 preparing lemon: drying raw materials, controlling water content<10 percent, crushing and sieving for standby, and extracting the cedar wood by using a supercritical extraction device, wherein the edible CO is edible grade2Purity not less than 99.9%, extraction parameters: CO22The flow is 1L/h, the extraction time is 6h, the temperature is 50 ℃, and the pressure of an extraction kettle is 10 MPa.
S5 mixing the lavender, cananga odorata, cedar and lemon prepared in S1-S4 according to the ratio of 5:2:2:1 to prepare a mixture.
S6 recombining the mixture in S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition, wherein the distillation environment is as follows: the feeding speed is 0.5mL/min, the molecular distillation temperature is 30 ℃, the film scraping rotation speed is 200 r/min, and the distillation pressure is 30 Pa.
Example two
S1 lavender preparation: natural air dryingCrushing and sieving for later use, and extracting the lavender by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 30L/h, the extraction time is 3h, the temperature is 40 ℃, and the pressure of the extraction kettle is 20 MPa.
S2 preparation of ylang: freeze-drying, crushing and sieving for later use, and extracting cananga odorata by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 25L/h, the extraction time is 3h, the temperature is 50 ℃, and the pressure of the extraction kettle is 20 MPa.
S3 preparation of cedar: naturally air-drying, crushing and sieving for later use, and extracting cypress by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 5L/h, the extraction time is 5h, the temperature is 70 ℃, and the pressure of the extraction kettle is 20 MPa.
S4 preparing lemon: drying raw materials, controlling water content<10 percent, crushing and sieving for standby, and extracting the cedar wood by using a supercritical extraction device, wherein the edible CO is edible grade2Purity not less than 99.9%, extraction parameters: the flow rate of CO2 is 2L/h, the extraction time is 7h, the temperature is 50 ℃, and the pressure of the extraction kettle is 20 MPa.
S5, mixing the lavender, the ylang-ylang, the cedar wood and the lemon prepared in the S1-S4 according to the proportion of 5:2:2:1, and compounding to obtain a mixture, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2, purity not less than 99.9%, extraction parameters: CO22The flow rate is 2L/h, the extraction time is 7h, the temperature is 50 ℃, and the pressure of the extraction kettle is 20 MPa.
S6, recombining the mixture in the S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition, wherein the distillation environment is as follows: the feeding speed is 2 mL/min, the molecular distillation temperature is-60 ℃, the film scraping rotation speed is 300 r/min, and the distillation pressure is 50 Pa.
Example three:
s1 lavender preparation: naturally air drying, pulverizing, sieving, and extracting with supercritical extraction deviceThe extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 22L/h, the extraction time is 2h, the temperature is 35 ℃, and the pressure of the extraction kettle is 10 MPa.
S2 preparation of ylang: freeze-drying, crushing and sieving for later use, and extracting cananga odorata by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 16L/h, the extraction time is 2.5h, the temperature is 40 ℃, and the pressure of the extraction kettle is 15 MPa.
S3 preparation of cedar: naturally air-drying, crushing and sieving for later use, and extracting cypress by using a supercritical extraction device, wherein the extraction environment of the supercritical extraction device is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: the flow rate of CO2 is 2L/h, the extraction time is 4h, the temperature is 70 ℃, and the pressure of the extraction kettle is 12 MPa.
S4 preparing lemon: drying raw materials, controlling water content<10 percent, crushing and sieving for standby, and extracting the cedar wood by using a supercritical extraction device, wherein the edible CO is edible grade2Purity not less than 99.9%, extraction parameters: CO22The flow rate is 0.5L/h, the extraction time is 6h, the temperature is 50 ℃, and the pressure of the extraction kettle is 15 MPa.
S5 mixing the lavender, cananga odorata, cedar and lemon prepared in S1-S4 according to the ratio of 5:2:2:1 to prepare a mixture.
S6 recombining the mixture in S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition, wherein the distillation environment is as follows: the feeding speed is 1 mL/min, the molecular distillation temperature is 50 ℃, the film scraping rotation speed is 240 r/min, and the distillation pressure is 45 Pa.
The hypnotic essential oil composition with quick response prepared by the invention has the following physical properties: the appearance color is dark brown, thick and opaque, the aroma characteristic is rich, mellow and good in body feeling, and the appearance color of the compound mixture before recombination is light brown, semitransparent and slightly irritant.
The animal experiments and results of the hypnotic essential oil composition of the present invention are described in detail below.
(1) Animal grouping and administration
ICR mice are selected, and the sex is half of the sex; during the experiment, enough food and water can be obtained by animals, the temperature of the feeding environment in the experiment room is 21 +/-1 ℃, the humidity is 55% +/-5%, the light and shade are alternated for 12h, the animals can drink water and eat food freely, and the experiment is started after 1 week of adaptive feeding.
The experiment is provided with a blank group (normal feeding), 3 hypnotic essential oil compositions (a group for 1 day of inhalation administration, a group for 7 days of inhalation administration and a group for 14 days of inhalation administration), and 3 positive medicines (a group for 1 day of positive medicine administration, a group for 7 days of positive medicine administration and a group for 14 days of positive medicine administration).
Wherein, the daily inhalation concentration of each group of mice of the hypnotic essential oil composition group is 2x10-3The hypnotic essential oil composition (effective inhalation concentration measured by a pre-experiment, the hypnotic essential oil composition is diluted by tween-80 solution with the concentration of 1 percent), the ultrasonic atomization aromatherapy machine is placed in an animal aromatherapy chamber, so that the medicine is fully volatilized and diffused in the whole aromatherapy chamber, then each group of mice of the hypnotic essential oil composition are sequentially placed in the aromatherapy chamber, a box cover is covered, continuous inhalation administration is carried out for 60min, and the inhalation time period is 8: 00-16: 00.
the diazepam is prepared into a 0.1mg/mL solution by using distilled water, the administration dosage of the positive drug of each group of the gavage diazepam solution is 1mg/kg, and the blank group and the hypnotic essential oil composition of each group of the gavage isopyknic steam hydrophobic.
(2) Mouse autonomic activity test
After each group of mice is dosed for 30min at the last time, each group of mice is respectively subjected to an autonomic activity test, the mice adapt to the environment for 5min, the behavioral parameters such as the moving distance and the standing times of the mice within 3min are counted, the difference among the groups of mice is compared, and autonomic activity test indexes are as follows: travel distance, unit: cm; maximum speed, unit: cm/s; average speed: unit: cm/s; rest time, unit: s; the number of times of standing.
(3) Pentobarbital sodium induced sleep latency and sleep time
After the autonomic activity test is finished, the mice in each group are respectively injected with pentobarbital sodium with a threshold dose of 45mg/kg (the minimum dose for 100 percent of mice to sleep as measured in a preliminary experiment) in the abdominal cavity, and a pentobarbital sodium solution is prepared by using physiological saline before administration. Taking the disappearance of righting reflex of the mice for 1min after administration as an index of falling asleep, taking the time from the injection of the drug to the disappearance of the righting reflex as a sleep latency, taking the time from the disappearance of the righting reflex to the restoration as the sleep time, and recording the sleep latency and the sleep time of the mice.
The experimental results of the mouse autonomic activity test are shown in table 1 below, and the influence of the hypnotic essential oil composition on the moving distance, average speed, maximum speed, resting time and standing times of the mouse is shown.
Figure DEST_PATH_IMAGE002
Wherein, other groups are compared with blank group, P <0.05, P < 0.01.
The results showed that the group administered by inhalation for 1 day showed sedative-hypnotic effect, the groups administered by inhalation for 7 days and 14 days showed extremely significant sedative-hypnotic effect, the mice had extremely significant decrease in the amount of autonomic activity, as evidenced by extremely significant decrease in the distance traveled and the number of standing times (P < 0.01), extremely significant decrease in the mean velocity and the maximum velocity (P < 0.01), extremely significant increase in the resting time (P < 0.01), and extremely significant sedative-hypnotic effect in the group administered by positive drug for 1 day (P < 0.01), and the mice had increased in the group administered by positive drug for 7 days and by positive drug for 14 days as the administration time was extended.
The results of the pentobarbital sodium-induced sleep latency and sleep time experiments are shown in table 2 below.
Figure DEST_PATH_IMAGE004
The results showed that in the sleep latency, the group administered with the positive drug for 1 day had a very significant decrease in sleep latency (P < 0.01) compared to the blank group, followed by the group administered with the positive drug for 7 days (P < 0.01) and 14 days (P < 0.01), and the group administered with the positive drug for 14 days had a tendency to increase in sleep latency with the increase in administration time.
In terms of sleep time, the sleep time of the group administered with the positive drug for 1 day was significantly increased (P < 0.01) compared to the blank group, and then the group administered with the positive drug for 7 days (P < 0.01) and the group administered with the positive drug for 14 days (P < 0.01) tended to decrease with the increase in the administration time.
The experiments show that the hypnotic essential oil composition has the effects of tranquilizing and hypnotizing, can obviously reduce the autonomous activity of animals, shortens the sleep latency and prolongs the sleep time.
The above is only a specific application example of the present invention, and the protection scope of the present invention is not limited in any way. All the technical solutions formed by equivalent transformation or equivalent replacement fall within the protection scope of the present invention.

Claims (7)

1. A preparation method of a hypnotic essential oil composition with quick response is characterized by comprising the following steps:
s1 lavender preparation: naturally drying, pulverizing, sieving, and extracting Lavender with supercritical extraction device;
s2 preparation of ylang: freeze drying, pulverizing, sieving, and extracting with supercritical extraction device;
s3 preparation of cedar: naturally drying, pulverizing, sieving, and extracting cypress with supercritical extraction device;
s4 preparing lemon: drying the raw materials, controlling the water content to be less than 10%, crushing and sieving for later use, and extracting the cedar by using a supercritical extraction device;
s5 mixing lavender, cananga odorata, cedar and lemon prepared in S1-S4 according to the proportion of 5:2:2:1 to prepare a mixture;
s6 recombining the mixture in S5 by molecular distillation to obtain a fraction, namely the hypnotic essential oil composition.
2. The method for preparing a rapid-onset hypnotic essential oil composition as set forth in claim 1, wherein the extraction ring of the supercritical extraction device is at S1The environment is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 22-30L/h, the extraction time is 2-3h, the temperature is 30-40 ℃, and the pressure of the extraction kettle is 10-20 MPa.
3. The method for preparing a rapid-onset hypnotic essential oil composition as set forth in claim 1, wherein the extraction environment of the supercritical extraction device in S2 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 10-25L/h, the extraction time is 2-3h, the temperature is 35-50 ℃, and the pressure of the extraction kettle is 10-20 MPa.
4. The method for preparing a rapid-onset hypnotic essential oil composition as set forth in claim 1, wherein the extraction environment of the supercritical extraction device in S3 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 1-5L/h, the extraction time is 3-5h, the temperature is 70 ℃, and the pressure of the extraction kettle is 10-20 MPa.
5. The method as claimed in claim 1, wherein the supercritical extraction apparatus has the following extraction environment in S4: the extraction environment of the supercritical extraction apparatus in S4 is as follows: food grade CO2Purity not less than 99.9%, extraction parameters: CO22The flow is 0.1-2L/h, the extraction time is 6-7h, the temperature is 50 ℃, and the pressure of the extraction kettle is 10-20 MPa.
6. The method of claim 1, wherein the molecular distillation is performed in a distillation environment as follows: the feeding speed is 0.5-2 mL/min, the molecular distillation temperature is 30-60 ℃, the film scraping rotation speed is 200-300 r/min, and the distillation pressure is 30-50 Pa.
7. A fast-acting hypnotic essential oil composition is characterized in that the fast-acting hypnotic essential oil composition is prepared by mixing and compounding lavender, ylang-ylang, cedar and lemon according to the proportion of 5:2:2:1, and recombining by molecular distillation.
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Application publication date: 20201225