CN104740011A - Essential oil for calming nerves and promoting sleep and preparation method thereof - Google Patents

Essential oil for calming nerves and promoting sleep and preparation method thereof Download PDF

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CN104740011A
CN104740011A CN201510159565.9A CN201510159565A CN104740011A CN 104740011 A CN104740011 A CN 104740011A CN 201510159565 A CN201510159565 A CN 201510159565A CN 104740011 A CN104740011 A CN 104740011A
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essential oil
parts
lavender
sleep
benzoin
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马瑞君
刘晓生
吴清韩
朱慧
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Hanshan Normal University
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Abstract

本发明提供了一种用于安神促眠的精油及其制备方法,精油主要由以下原料制成:以体积份数计,柠檬精油30-80份,薰衣草精油0-50份,罗马甘菊精油0-30份,安息香精油0-30份。制备方法包括如下步骤:将所述柠檬精油、薰衣草精油、罗马甘菊精油以及所述安息香精油混合均匀,即得。本发明实施例的精油适用于不同人群,适用范围广、具有安神减压、缓解紧张情绪、促进睡眠和静心的疗效,还具有延长睡眠时间等效果。The invention provides an essential oil for calming the nerves and promoting sleep and a preparation method thereof. The essential oil is mainly made of the following raw materials: in parts by volume, 30-80 parts of lemon essential oil, 0-50 parts of lavender essential oil, Roman chamomile essential oil 0-30 parts, benzoin essential oil 0-30 parts. The preparation method comprises the following steps: uniformly mixing the lemon essential oil, lavender essential oil, Roman chamomile essential oil and the benzoin essential oil to obtain the finished product. The essential oil of the embodiment of the present invention is suitable for different groups of people, has a wide range of applications, has the effects of calming the nerves and reducing stress, relieving tension, promoting sleep and meditation, and also has the effects of prolonging sleep time and the like.

Description

一种用于安神促眠的精油及其制备方法A kind of essential oil for calming the nerves and promoting sleep and preparation method thereof

技术领域technical field

本发明涉及精油配方制作领域,具体而言,涉及一种用于安神促眠的精油及其制备方法。The invention relates to the field of preparation of essential oil formulas, in particular to an essential oil for calming the nerves and promoting sleep and a preparation method thereof.

背景技术Background technique

现如今,随着快节奏的生活,人们的生活压力也普遍比较大,失眠或睡眠质量不佳给人们带来极大的痛苦和心理负担,难以入睡、睡眠不沉或睡眠时间短为其主要症状。患者从年轻的学子、老年人群及成功人士中皆有,在校学生甚至有因长期失眠痛苦不堪而导致自杀的。目前现有技术中,主要采取服用如安定等西药或安神补心类中药进行有效缓解症状,也有通过精油香薰、香枕等方法进行辅助治疗的。Nowadays, with the fast-paced life, people’s life pressure is generally relatively high. Insomnia or poor sleep quality bring great pain and psychological burden to people. symptom. Patients range from young students, elderly people, and successful people, and even school students commit suicide due to long-term insomnia and suffering. In the current prior art, it is mainly taken to take western medicines such as diazepam or traditional Chinese medicines for calming the nerves to effectively relieve symptoms, and some methods such as aromatherapy with essential oils and incense pillows are also used for auxiliary treatment.

但是,长期服用西药总让人心有疑虑,担心是否副作用比较大引起其他病症;中药相对容易接受,但煎煮中药麻烦,特别是对在校学生来说,较难实现,而且见效缓慢。精油香薰需要电源,但学校通常会定时关灯断电,且效果尚需要确认不说,其由于需要用电也会带来一定的安全隐患;另外,使用香枕效果难以持久且成本比较高。However, long-term use of western medicine always makes people have doubts, worrying about whether the side effects may cause other diseases; Chinese medicine is relatively easy to accept, but it is troublesome to decoct Chinese medicine, especially for school students, it is difficult to achieve, and the effect is slow. Essential oil aromatherapy requires a power supply, but schools usually turn off the lights and power off regularly, and the effect needs to be confirmed. Not to mention, it will also bring certain safety hazards due to the need for electricity; in addition, the effect of using aroma pillows is difficult to last and the cost is relatively high.

有鉴于此,特提出本发明。In view of this, the present invention is proposed.

发明内容Contents of the invention

本发明的第一目的在于提供一种安神促眠的精油,所述的精油克服了上述技术问题,这种精油适用于不同人群,适用范围广、具有安神减压、缓解紧张情绪、促进睡眠和静心的疗效,还具有延长睡眠时间等优点。The first object of the present invention is to provide an essential oil for calming the nerves and promoting sleep. The essential oil overcomes the above-mentioned technical problems. This essential oil is suitable for different groups of people and has a wide range of applications. The curative effect of meditation also has the advantages of prolonging sleep time.

本发明的第二目的在于提供一种所述的安神促眠的精油的制备方法,该方法具有制作简单、操作方便以及制作成本低,能完整的保留精油中每个组分的有效成份等优点。The second object of the present invention is to provide a method for preparing the essential oil for calming the nerves and promoting sleep. The method has the advantages of simple production, convenient operation, low production cost, and the ability to completely retain the active ingredients of each component in the essential oil. .

为了实现本发明的上述目的,特采用以下技术方案:In order to realize the above-mentioned purpose of the present invention, special adopt following technical scheme:

本发明实施例的安神促眠的精油,主要由以下原料制成:以体积份数计,柠檬精油30-80份,薰衣草精油0-50份,罗马甘菊精油0-30份,安息香精油0-30份。The sedative and sleep-promoting essential oil of the embodiment of the present invention is mainly made of the following raw materials: in parts by volume, 30-80 parts of lemon essential oil, 0-50 parts of lavender essential oil, 0-30 parts of Roman chamomile essential oil, and 0-30 parts of benzoin essential oil -30 servings.

本发明实施例的安神促眠的精油,可直接由柠檬精油一种成份制成,柠檬精油主要是从柠檬果皮中通过水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取其精华物质所得。柠檬精油具有柠檬清新的香气,可以帮助提神精神,缓解烦躁,对于皮肤及身体也有很多积极的调理作用,其中富含丰富的维生素C,特别有益于美白、收敛、平衡油脂分泌、治疗青春痘等油性皮肤症状。具有愉快凉爽以及新鲜之感,能够给人带来清新的感受,从而达到舒缓紧张或焦虑的情绪。本发明选用的柠檬精油最好由以下几种主要成份组成:以体积百分比计,柠檬烯50-60%、γ-松油烯10-20%、β-蒎烯10-20%。市面上一般柠檬精油中的柠檬烯这种成份的体积百分比达不到50%,但是如果柠檬精油中的这种成份含量过低,那么制备出的精油成品也达不到本发明的具有安神促眠、延长睡眠时间的效果,相反的如果某种组分含量过高,又会起到相反的效果,使用后整个人变得昏昏沉沉,没有精神,因此在具体选用柠檬精油这种原料时,需要检测其所含的主要成份是否在适当的范围内,从而使得疗效最佳,其可以通过市售获得也可采取上述描述的方式进行自行制备获得,但是无论采取哪种方式其有效成份的含量最好在适宜的范围内。The sedative and sleep-promoting essential oil of the embodiment of the present invention can be directly made from a component of lemon essential oil. Lemon essential oil is mainly obtained from lemon peel by any one of steam distillation, pressing, extraction, and carbon dioxide critical extraction. A method to extract its essence. Lemon essential oil has a fresh aroma of lemon, which can help refresh the mind and relieve irritability. It also has many positive conditioning effects on the skin and body. It is rich in vitamin C, which is especially beneficial for whitening, astringent, balancing oil secretion, and treating acne, etc. Oily skin symptoms. It has a pleasant cool and fresh feeling, which can bring people a refreshing feeling, so as to relieve tension or anxiety. The lemon essential oil selected by the present invention preferably consists of the following main components: 50-60% of limonene, 10-20% of gamma-terpinene and 10-20% of beta-pinene in terms of volume percentage. The volume percentage of limonene in the general lemon essential oil on the market cannot reach 50%, but if the content of this component in the lemon essential oil is too low, then the finished essential oil can not reach the sedative and sleep-promoting effect of the present invention. 1. The effect of prolonging sleep time. On the contrary, if the content of a certain component is too high, it will have the opposite effect. After using it, the whole person becomes drowsy and lacks energy. It is necessary to detect whether the main ingredients it contains are within the appropriate range, so as to make the best curative effect. It can be obtained from the market or prepared by the method described above, but no matter which method is used, the content of the active ingredients Preferably within the appropriate range.

另外,处于经济成本的考虑以及人们在使用时的自我感受的考虑,为了能够降低成本还能使得人们在使用精油时,其香气柔和清香,能被广大人群所接受,其最好还包括其他三种原料,薰衣草精油,罗马甘菊精油,安息香精油,而柠檬精油作为疗效显著的一种原料其加量也较大,体积份数为30-80份,较优的为50-80份,更优的为60-70份,还可以选取35份、40份以及45份等。In addition, in consideration of economic cost and people's self-feeling when using essential oils, in order to reduce costs and make people use essential oils with a soft and delicate fragrance, which can be accepted by the majority of people, it is best to include the other three essential oils. A variety of raw materials, lavender essential oil, Roman chamomile essential oil, benzoin essential oil, and lemon essential oil as a raw material with significant curative effect, its dosage is also relatively large, the volume parts are 30-80 parts, preferably 50-80 parts, more The best is 60-70 copies, and 35, 40, and 45 copies can also be selected.

薰衣草精油一般添加量为0-50份,较优的为10-30份,更优的为15-35份,还可以选择20份、25份以及38份等;薰衣草精油本身气味非常的清新淡雅,可以与柠檬精油相配合调配出更柔和的精油气味,具有平缓神经紧张,减压镇静,平衡神经及情绪化的功效,尤其对中枢神经具有很好的镇静作用,因此最好取用适当的体积份数作为原料制备精油。同样的,所述薰衣草精油最好含有以下几种主要成份:以体积百分比计,芳樟醇35-45%,乙酸芳樟醇20-30%、乙酸薰衣草酯10-25%,α-松油醇4-15%。在进行选用时最好对所含的主要成份进行检测,只有每种成份在合适的指标范围内,作为原料制备出的精油其效果才最佳。薰衣草精油可通过市售获得,也可采用以下的提取方法:从薰衣草全草中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质得到。The general dosage of lavender essential oil is 0-50 parts, the better one is 10-30 parts, the more optimal one is 15-35 parts, and 20 parts, 25 parts and 38 parts can also be selected; the smell of lavender essential oil itself is very fresh and elegant , can be combined with lemon essential oil to produce a softer essential oil smell, which has the effects of relieving nervous tension, decompression and sedation, balancing nerves and emotions, especially has a good sedative effect on the central nervous system, so it is best to take appropriate Parts by volume are used as raw materials for the preparation of essential oils. Equally, described lavender essential oil preferably contains following several main components: by volume percentage, linalool 35-45%, linalool acetate 20-30%, lavender acetate 10-25%, α-pine oil Alcohol 4-15%. It is best to test the main components contained in the selection. Only when each component is within the appropriate index range, the effect of the essential oil prepared as a raw material will be the best. Lavender essential oil can be obtained commercially, and the following extraction methods can also be used: extract the essence from the whole lavender by steam distillation, pressing, extraction, and carbon dioxide critical extraction.

罗马甘菊精油一般添加量为0-30份,较优的为5-10份,更优的为8-10份,还可以选择15份、20份以及25份等;罗马甘菊精油本身具有平衡镇静、情绪安抚、缓解肌肤酸痛及关节肿、强化消化系统以及调理肠胃的作用,尤其对失眠、紧张及忧郁不安有安抚的作用,可以舒解焦虑,镇定心情,因此其作为原料与其他原料相互配合使得制备出的精油的效果更好;罗马甘菊精油的主要成份为异丙基萘,这种成份的含量最好占到20%以上,以使其能够满足所要达到的疗效的要求,罗马甘菊精油可通过市售获得,也可采用以下的提取方法:所述罗马甘菊精油的提取方法为从甘菊中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得。Roman chamomile essential oil is generally added in an amount of 0-30 parts, preferably 5-10 parts, more preferably 8-10 parts, and can also choose 15 parts, 20 parts, and 25 parts; Roman chamomile essential oil itself has Balance and calm, soothe emotions, relieve skin pain and joint swelling, strengthen the digestive system and regulate the stomach, especially for insomnia, tension and depression. It can relieve anxiety and calm the mood. Therefore, it is used as a raw material and other raw materials Mutual cooperation makes the effect of the prepared essential oil better; the main component of Roman chamomile essential oil is isopropyl naphthalene, and the content of this component should preferably account for more than 20%, so that it can meet the requirements of the curative effect to be achieved, Roman chamomile essential oil can be commercially available, and the following extraction methods can also be used: the extraction method of the Roman chamomile essential oil is any one of steam distillation, pressing, extraction, and carbon dioxide critical extraction from chamomile. A method to extract the essence of the substance obtained.

安息香精油的一般添加量为0-30份,较优的为5-10份,更优的为8-10份,还可以选择6份、7份以及9份等,安息香精油本身具有香甜气味,香气怡人可以很好的调和精油的气味,而且具有安神、缓解紧张情绪的功效,在进行选择时最好选择主要成份以及用量为以下几种的安息香精油:以体积百分比计,3-苯基-2-丙烯醛40-50%、肉桂酸苄酯40-50%、苯甲酸苄脂8-15%;每种成份以及用量最好在适宜的范围内,选择具有这种特定成份的安息香精油作为原料,能够使得制备出的成品品质比较高,而且疗效显著,人们在使用时也能够很快起到安神促眠的作用。因此发明人在具体选用每种原料时均是通过检测其各个指标后并做了大量的实验,才得到最适宜的成份以及最适宜的用量的。安息香精油可以通过市售获得也可通过下述提取方法获得:从安息香花中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得。The general addition amount of benzoin essential oil is 0-30 parts, preferably 5-10 parts, more preferably 8-10 parts, and can also choose 6 parts, 7 parts and 9 parts, etc. Benzoin essential oil itself has a sweet smell, Pleasant aroma can well reconcile the smell of essential oils, and has the effect of calming the nerves and relieving tension. When making a choice, it is best to choose benzoin essential oils with the following main components and dosages: by volume percentage, 3-phenyl - 40-50% of 2-propenal, 40-50% of benzyl cinnamate, 8-15% of benzyl benzoate; each ingredient and dosage should be within the appropriate range, choose benzoin essential oil with this specific ingredient As a raw material, the quality of the prepared finished product can be relatively high, and the curative effect is remarkable, and when people use it, it can quickly play the role of calming the nerves and promoting sleep. Therefore the contriver all is by detecting its each index and has done a large amount of experiments when concretely selecting every kind of raw material, just obtains the most suitable composition and the most suitable consumption. The benzoin essential oil can be obtained commercially or by the following extraction method: extract the essence from benzoin flowers by steam distillation, pressing, extraction, and carbon dioxide critical extraction.

本发明实施例还提供了一种安神促眠的精油的制备方法,包括如下步骤:将所述柠檬精油、薰衣草精油、罗马甘菊精油以及所述安息香精油混合均匀,即得。这种制备方法操作上比较简单,但是疗效却很显著,其可以进行混合后以油状液体的状态进行使用,也可以选择再继续加工的方式,制备成凝胶固体剂型,具体进行使用时,放一块直径约1cm的缓释胶状固体球于枕头的左右两侧即可,使用方法非常简单。The embodiment of the present invention also provides a preparation method of an essential oil for calming the nerves and promoting sleep, comprising the following steps: uniformly mixing the lemon essential oil, lavender essential oil, Roman chamomile essential oil and the benzoin essential oil to obtain the product. This preparation method is relatively simple in operation, but the curative effect is very significant. It can be mixed and used in the state of oily liquid, or it can be further processed to prepare a gel solid dosage form. A slow-release colloidal solid ball with a diameter of about 1cm can be placed on the left and right sides of the pillow. The method of use is very simple.

制备成凝胶固体剂型的具体方法如下:The concrete method that is prepared into gel solid dosage form is as follows:

先取500ml双蒸水加热至80-90℃,加入硬脂酸钠9-11g、海藻酸钠6-8g、琼脂5-6g、吐温0.01ml,使用恒温磁力搅拌器,转速为200-250r/min,于80-90℃的恒温条件下搅拌2-3h,制得凝胶液,50-60℃恒温水浴中保存待用。然后将混合好的复方精油与凝胶液加入高压均质设备中,在温度75-85℃、压力30MPa的条件下均质四次,每次7min,均质后的混合液倒入模具,待冷却凝固即可包装,得到成品,取名凝胶型空气清新剂。First take 500ml of double-distilled water and heat it to 80-90°C, add 9-11g of sodium stearate, 6-8g of sodium alginate, 5-6g of agar, and 0.01ml of Tween, and use a constant temperature magnetic stirrer at a speed of 200-250r/ min, and stirred at a constant temperature of 80-90°C for 2-3 hours to obtain a gel solution, which was stored in a constant temperature water bath at 50-60°C until use. Then add the mixed compound essential oil and gel solution into the high-pressure homogenization equipment, homogenize four times under the conditions of temperature 75-85°C and pressure 30MPa, each time for 7 minutes, pour the homogenized mixture into the mold, and wait Cooling and solidification can be packaged to obtain a finished product, which is called a gel-type air freshener.

本发明将香薰疗法原理应用于凝胶型空气清新剂的制备中,并对4种芳香中草药植物精油设计了不同组合,可根据调养者身体状况及各人闻香喜好进行配伍,应用于安神调养,并改善室内空气质量。另外,本安神清新剂产品的制作工艺较为简单、产品安全性高、挥发率低、实用性强,适合家居、公司等场所,是一款绿色环保的产品。The present invention applies the principle of aromatherapy to the preparation of gel-type air fresheners, and designs different combinations of 4 kinds of aromatic Chinese herbal plant essential oils, which can be compatible according to the physical condition of the caregiver and each person's scent preference, and can be used for calming the nerves. , and improve indoor air quality. In addition, the Anshen freshener product has a relatively simple production process, high product safety, low volatility, and strong practicability. It is suitable for homes, companies and other places, and is a green and environmentally friendly product.

与现有技术相比,本发明的有益效果为:Compared with prior art, the beneficial effect of the present invention is:

(1)药效好,疗效显著,柠檬精油具有愉快、凉爽有清灵新鲜之感,使人精神放松;薰衣草精油对神经中枢系统有镇静作用;罗马甘菊精油芳香散湿,对失眠、紧张及忧郁不安有安抚的作用,可以舒解焦虑,镇定心情绪;安息香精油可芳香化湿、缓解紧张情绪安神;(1) Good medicinal effect and significant curative effect. Lemon essential oil has a pleasant, cool and fresh feeling, which makes people relax; lavender essential oil has a calming effect on the nervous central system; Roman chamomile essential oil is fragrant and damp, which is good for insomnia and tension It can relieve anxiety and calm emotions; benzoin essential oil can aromatize dampness, relieve tension and calm the nerves;

(2)本发明实施例的精油起到安神减压、缓解紧张情绪、促进睡眠和静心的,在延长睡眠时间上有明显的效果;(2) the essential oil of the embodiment of the present invention plays calming and decompression, relieves tension, promotes sleep and meditation, and has obvious effect on prolonging sleep time;

(3)药性好,用药方便,剂型多变,可以满足不同人群的需求,患者易于接受,不需要用电,无安全隐患存在,尤其方便在校学生进行使用;原料成本低,一周用量的成本仅10元左右。(3) It has good medicinal properties, convenient medication, and variable dosage forms, which can meet the needs of different groups of people. It is easy for patients to accept, does not require electricity, and has no potential safety hazards. It is especially convenient for school students to use; the cost of raw materials is low, and the cost of a week's dosage Only about 10 yuan.

具体实施方式Detailed ways

下面将结合实施例对本发明的实施方案进行详细描述,但是本领域技术人员将会理解,下列实施例仅用于说明本发明,而不应视为限制本发明的范围。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市售购买获得的常规产品。Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

实施例1Example 1

安神促眠的精油的具体制备方法如下:The specific preparation method of the essential oil for calming the nerves and promoting sleep is as follows:

1)先分别通过制备或购买的方式得到以下原料:柠檬精油、薰衣草精油、罗马甘菊精油以及安息香精油,柠檬精油是从柠檬果皮中采用水蒸气蒸馏法提取出来,经检测其主要成份为:按体积百分比,柠檬烯50%、γ-松油烯10%、β-蒎烯10%,其他成分占30%。其他三种精油通过购买获得,薰衣草精油的主要成份为:芳樟醇35%,乙酸芳樟醇30%、乙酸薰衣草酯25%,α-松油醇4%,其他成分占6%;罗马甘菊精油的主要成份为异丙基萘占有20%;安息香精油的主要成份如下:3-苯基-2-丙烯醛40%、肉桂酸苄酯50%、苯甲酸苄脂8%,其他成分2%;1) First obtain the following raw materials through preparation or purchase: lemon essential oil, lavender essential oil, Roman chamomile essential oil and benzoin essential oil. Lemon essential oil is extracted from lemon peel by steam distillation, and its main components are as follows: By volume percentage, limonene 50%, γ-terpinene 10%, β-pinene 10%, and other ingredients account for 30%. The other three essential oils are obtained through purchase. The main components of lavender essential oil are: 35% linalool, 30% linalool acetate, 25% lavender acetate, 4% α-terpineol, and 6% other ingredients; The main component of chrysanthemum essential oil is 20% of isopropyl naphthalene; the main components of benzoin essential oil are as follows: 3-phenyl-2-propenal 40%, benzyl cinnamate 50%, benzyl benzoate 8%, other components 2 %;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,70份柠檬精油、15份薰衣草精油、10份罗马甘菊精油、5份安息香精油,搅拌混合后得到混合精油;2) Mix the four unilateral essential oils according to the following proportions: in parts by volume, 70 parts of lemon essential oil, 15 parts of lavender essential oil, 10 parts of Roman chamomile essential oil, and 5 parts of benzoin essential oil are mixed to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例2Example 2

安神促眠的精油的具体制备方法如下:The specific preparation method of the essential oil for calming the nerves and promoting sleep is as follows:

1)先分别通过制备或购买的方式得到以下原料:柠檬精油、薰衣草精油、罗马甘菊精油以及安息香精油,薰衣草精油是从薰衣草全草中采用化学溶剂萃取法提取出来的精华物质所得,经检测其主要成份为:按体积百分比,芳樟醇45%,乙酸芳樟醇20%、乙酸薰衣草酯10%,α-松油醇15%,其他成分占10%;其他三种精油通过购买获得,柠檬精油的成份为:柠檬烯60%、γ-松油烯20%、β-蒎烯20%;罗马甘菊精油的主要成份为异丙基萘占有30%;安息香精油的主要成份如下:3-苯基-2-丙烯醛50%、肉桂酸苄酯40%、苯甲酸苄脂10%;1) First obtain the following raw materials through preparation or purchase: lemon essential oil, lavender essential oil, Roman chamomile essential oil and benzoin essential oil. Lavender essential oil is obtained from the essence extracted from the whole lavender herb by chemical solvent extraction. After testing Its main ingredients are: by volume percentage, 45% of linalool, 20% of linalool acetate, 10% of lavender acetate, 15% of α-terpineol, and 10% of other ingredients; the other three essential oils are obtained through purchase, The composition of lemon essential oil is: limonene 60%, γ-terpinene 20%, β-pinene 20%; The main component of Roman chamomile essential oil is 30% of isopropyl naphthalene; The main components of benzoin essential oil are as follows: 3- 50% phenyl-2-propenal, 40% benzyl cinnamate, 10% benzyl benzoate;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,80份柠檬精油、10份薰衣草精油、5份罗马甘菊精油、5份安息香精油,搅拌混合后得到混合精油;2) Mix the four unilateral essential oils according to the following proportions: in parts by volume, 80 parts of lemon essential oil, 10 parts of lavender essential oil, 5 parts of Roman chamomile essential oil, and 5 parts of benzoin essential oil, stir and mix to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例3Example 3

安神促眠的精油的具体制备方法如下:The specific preparation method of the essential oil for calming the nerves and promoting sleep is as follows:

1)先分别通过制备或购买的方式得到以下原料:柠檬精油、薰衣草精油、罗马甘菊精油以及安息香精油,罗马甘菊精油是从甘菊中采用二氧化碳临界萃取法提取出来,经检测其主要成份为异丙基萘占有20%;其他三种精油通过购买获得,柠檬精油按体积百分比,柠檬烯50%、γ-松油烯10%、β-蒎烯10%,其他成分占30%。薰衣草精油的主要成份为:芳樟醇35%,乙酸芳樟醇30%、乙酸薰衣草酯25%,α-松油醇4%,其他成分占6%;安息香精油的主要成份如下:3-苯基-2-丙烯醛40%、肉桂酸苄酯40%、苯甲酸苄脂15%,其他成分5%;1) First obtain the following raw materials through preparation or purchase: lemon essential oil, lavender essential oil, Roman chamomile essential oil and benzoin essential oil. Roman chamomile essential oil is extracted from chamomile by carbon dioxide critical extraction method. Propyl naphthalene accounted for 20%; the other three essential oils were obtained through purchase, lemon essential oil by volume percentage, limonene 50%, γ-terpinene 10%, β-pinene 10%, and other components accounted for 30%. The main components of lavender essential oil are: linalool 35%, linalool acetate 30%, lavender acetate 25%, α-terpineol 4%, and other components account for 6%; the main components of benzoin essential oil are as follows: 3-benzene 2-propenal 40%, benzyl cinnamate 40%, benzyl benzoate 15%, other ingredients 5%;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,50份柠檬精油、35份薰衣草精油、10份罗马甘菊精油、5份安息香精油;搅拌混合后得到混合精油;2) The four unilateral essential oils were mixed and prepared according to the following proportions: in parts by volume, 50 parts of lemon essential oil, 35 parts of lavender essential oil, 10 parts of Roman chamomile essential oil, and 5 parts of benzoin essential oil; the mixed essential oil was obtained after mixing;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例4Example 4

1)通过市售购买得到柠檬精油,备用;1) Obtain lemon essential oil through commercial purchase, for subsequent use;

2)取500ml双蒸水加热至80-90℃,加入硬脂酸钠9-11g、海藻酸钠6-8g、琼脂5-6g、吐温0.01ml,使用恒温磁力搅拌器,转速为200-250r/min,于80-90℃的恒温条件下搅拌2-3h,制得凝胶液,50-60℃恒温水浴中保存待用;2) Take 500ml of double-distilled water and heat it to 80-90°C, add 9-11g of sodium stearate, 6-8g of sodium alginate, 5-6g of agar, and 0.01ml of Tween, and use a constant temperature magnetic stirrer at a speed of 200- Stir at 250r/min at a constant temperature of 80-90°C for 2-3h to obtain a gel solution, which is stored in a constant temperature water bath at 50-60°C until use;

3)将柠檬精油与凝胶液按照1:1的体积比混合加入高压均质设备中,在温度75-85℃、压力30MPa的条件下均质四次,每次7min,均质后的混合液倒入模具,待冷却凝固即可包装,得到成品。3) Mix the lemon essential oil and the gel solution according to the volume ratio of 1:1 and add them to the high-pressure homogenization equipment, and homogenize four times at a temperature of 75-85°C and a pressure of 30MPa, each time for 7 minutes, and mix after homogenization The liquid is poured into the mold, and it can be packaged after being cooled and solidified to obtain the finished product.

实施例5Example 5

1)通过市售购买得到柠檬精油与薰衣草精油,检测柠檬精油其有效成分为:柠檬烯55%、γ-松油烯15%、β-蒎烯20%,其他成分占10%;薰衣草精油检测其有效成分如下:芳樟醇35%,乙酸芳樟醇30%、乙酸薰衣草酯25%,α-松油醇4%,其他成分占6%;1) Lemon essential oil and lavender essential oil were obtained through commercial purchase, and the effective components of lemon essential oil were: limonene 55%, γ-terpinene 15%, β-pinene 20%, and other components accounted for 10%; lavender essential oil detected its The active ingredients are as follows: linalool 35%, linalool acetate 30%, lavender acetate 25%, α-terpineol 4%, other ingredients 6%;

2)将两种单方精油按照以下比例进行混合调配:以体积份数计,30份柠檬精油、50份薰衣草精油搅拌混合后得到混合精油;2) The two unilateral essential oils are mixed and prepared according to the following ratio: in parts by volume, 30 parts of lemon essential oil and 50 parts of lavender essential oil are stirred and mixed to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例6Example 6

1)本步骤的制备方法与实施例1相同;1) the preparation method of this step is identical with embodiment 1;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,60份柠檬精油、30份薰衣草精油、30份罗马甘菊精油、10份安息香精油,搅拌混合后得到混合精油;2) Mix the four unilateral essential oils according to the following proportions: in parts by volume, 60 parts of lemon essential oil, 30 parts of lavender essential oil, 30 parts of Roman chamomile essential oil, and 10 parts of benzoin essential oil are mixed to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例7Example 7

1)本步骤的制备方法与实施例2相同;1) the preparation method of this step is identical with embodiment 2;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,60份柠檬精油、30份薰衣草精油、8份罗马甘菊精油、30份安息香精油,搅拌混合后得到混合精油;2) Mix the four unilateral essential oils according to the following proportions: in parts by volume, 60 parts of lemon essential oil, 30 parts of lavender essential oil, 8 parts of Roman chamomile essential oil, and 30 parts of benzoin essential oil, stir and mix to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实施例8Example 8

1)本步骤的制备方法与实施例3相同;1) the preparation method of this step is identical with embodiment 3;

2)将四种单方精油按照以下比例进行混合调配:以体积份数计,30份柠檬精油、30份薰衣草精油、8份罗马甘菊精油、8份安息香精油,搅拌混合后得到混合精油;2) Mix the four unilateral essential oils according to the following proportions: in parts by volume, 30 parts of lemon essential oil, 30 parts of lavender essential oil, 8 parts of Roman chamomile essential oil, and 8 parts of benzoin essential oil, stir and mix to obtain a mixed essential oil;

3)分装、贴标以及加上外包装后,即得成品。3) After packaging, labeling and adding outer packaging, the finished product is obtained.

实验例1Experimental example 1

测试方法用ND-97数字化脑电图仪测试(上海高科技公司)Test method Tested with ND-97 digital electroencephalograph (Shanghai Hi-Tech Co., Ltd.)

原理:脑电波来源于脑皮层锥体细胞的树突电活动,普遍认为是许多神经元细胞外电流所产生电场的总和,已成为评定中枢神经系统变化的重要指标之一。目前人们在研究中,根据在脑电波中发现各种节律的频率,将脑电波分成以下4种类型:频率为0.5-3.5Hz的δ波、频率为4-7.5Hz的θ波、频率为8-13.5Hz的α波、频率为14-30Hz的β波。虽未完全探明楚脑电波的发生机制,但已有研究表明人的精神因素对脑电活动有很大的影响,并且当人的精神状态发生改变时,我们可以用从头皮观测的电位去反演脑内电活动源的信息。其中,当精神紧张或情绪激动时,β节律得到明显增强,β波可以作为情绪稳定的一个指标来反映人的情绪变化;当心情放松且意识集中时,脑电图以α节律为主,α节律是正常成年人脑电图的基本节律;当人脑处于低觉醒水平或做梦、催眠状态、打盹等下意识活动中,θ波会显著增强;当成年人处于睡眠期时,它的比例会明显提高。因此,可以通过脑电波分析来间接的评价人的精神状态以及某些心理活动,这类研究主要是想通过分析θ波在脑电波中所占比例来评价植物精油的安神促眠功效,这种评价方法已普遍用于药物安神功效的评价。Principle: Brain waves originate from the dendritic electrical activity of the pyramidal cells in the cerebral cortex. It is generally believed that it is the sum of the electric fields generated by the extracellular currents of many neurons. It has become one of the important indicators for evaluating changes in the central nervous system. In current research, according to the frequency of various rhythms found in brain waves, brain waves are divided into the following four types: delta waves with a frequency of 0.5-3.5 Hz, theta waves with a frequency of 4-7.5 Hz, and 8 waves with a frequency of 8 Hz. Alpha waves at -13.5Hz, beta waves at a frequency of 14-30Hz. Although the mechanism of brain wave generation has not been fully ascertained, studies have shown that human mental factors have a great influence on brain electrical activity, and when a person's mental state changes, we can use the potential observed from the scalp to detect Retrieve information about the source of electrical activity in the brain. Among them, when the mind is tense or emotional, the β rhythm is significantly enhanced, and the β wave can be used as an indicator of emotional stability to reflect changes in people's emotions; when the mood is relaxed and the consciousness is concentrated, the EEG is dominated by the α rhythm, and the α wave Rhythm is the basic rhythm of EEG in normal adults; when the human brain is in a low level of arousal or in subconscious activities such as dreaming, hypnosis, and napping, theta waves will be significantly enhanced; when adults are in sleep, its proportion will be obvious improve. Therefore, brain wave analysis can be used to indirectly evaluate people's mental state and certain psychological activities. This type of research mainly wants to evaluate the tranquilizing and sleep-promoting effect of plant essential oils by analyzing the proportion of θ waves in brain waves. The evaluation method has been widely used in the evaluation of the tranquilizing efficacy of drugs.

在大学生中招募的60位志愿者,按照仪器操作的标准方法在志愿者头部安放的电极头,分别让学生吸溴单种精油及不同配比浓度的复方精油,仪器自动记录脑电图的变化,通过分析θ波在脑电波中所占比例,筛选出了具有明显安神促眠功效的精油的最佳实施例配方有3种:60 volunteers were recruited among college students. The electrode heads were placed on the volunteers' heads according to the standard method of instrument operation, and the students were asked to inhale bromine single essential oils and compound essential oils with different concentrations. The instrument automatically recorded the EEG. Changes, by analyzing the proportion of θ waves in brain waves, the best embodiment formulas of essential oils with obvious tranquilizing and sleep-promoting effects have been screened out:

实施例1:70份柠檬精油、15份薰衣草精油、10份罗马甘菊精油、5份安息香精油;Embodiment 1: 70 parts of lemon essential oils, 15 parts of lavender essential oils, 10 parts of Roman chamomile essential oils, 5 parts of benzoin essential oils;

实施例2:80份柠檬精油、10份薰衣草精油、5份罗马甘菊精油、5份安息香精油;Embodiment 2: 80 parts of lemon essential oils, 10 parts of lavender essential oils, 5 parts of Roman chamomile essential oils, 5 parts of benzoin essential oils;

实施例3:50份柠檬精油、35份薰衣草精油、10份罗马甘菊精油、5份安息香精油;Embodiment 3: 50 parts of lemon essential oils, 35 parts of lavender essential oils, 10 parts of Roman chamomile essential oils, 5 parts of benzoin essential oils;

实验例2Experimental example 2

对自述睡眠质量不佳或难以入眠的大学生20位,首先统计各位学生近3天的平时睡眠时间,再让他们睡前在枕边滴施本发明实施例1-2的精油,1-10位的大学生采用本发明实施例1的精油,11-20位的大学生采用本发明实施例2的精油,重复3天,统计每天的睡眠时间,取平均值作为测试后的数据,然后用SPSS统计软件中的配对样本T-检验的方法,进行用油前后的对比分析,看其有无显著性差异。For 20 college students who report that their sleep quality is poor or difficult to fall asleep, first count the usual sleep time of each student in the past 3 days, and then let them drop the essential oil of the embodiment of the present invention 1-2 on the pillow before going to bed, 1-10 college students adopt the essential oil of the embodiment of the present invention 1, and 11-20 college students adopt the essential oil of the embodiment of the present invention 2, repeat 3 days, count the sleep time every day, get the average value as the data after the test, then use SPSS statistical software Using the paired sample T-test method in the article, a comparative analysis is carried out before and after using the oil to see if there is a significant difference.

表1使用本发明的精油前后睡眠时间的统计(单位:小时)Table 1 uses the statistics (unit: hour) of sleep time before and after the essential oil of the present invention

11 22 33 44 55 66 77 88 99 1010 用油前Before using oil 4.04.0 5.05.0 3.3. 5.05.0 4.04.0 4.54.5 2.02.0 4.04.0 5.05.0 5.55.5 用油后after using oil 6.06.0 5.05.0 6.56.5 6.06.0 6.56.5 5.05.0 4.04.0 4.04.0 5.55.5 7.07.0 编号serial number 1111 1212 1313 1414 1515 1616 1717 1818 1919 2020 用油前Before using oil 4.04.0 4.04.0 5.55.5 3.03.0 3.53.5 3.53.5 4.04.0 4.54.5 5.05.0 5.05.0 用油后after using oil 4.04.0 6.06.0 8.08.0 6.06.0 4.04.0 4.04.0 4.04.0 7.57.5 6.06.0 5.05.0

从上表1可以看出,使用本发明实施例的精油后,具有显著延长睡眠时间的效果,因此本发明制备出的精油药效好,疗效显著;本发明实施例的精油起到安神减压、缓解紧张情绪、促进睡眠和静心的,在延长睡眠时间上有明显的效果。It can be seen from the above table 1 that after using the essential oil of the embodiment of the present invention, it has the effect of significantly prolonging the sleep time, so the essential oil prepared by the present invention has good drug effect and significant curative effect; the essential oil of the embodiment of the present invention can calm the nerves and reduce stress , relieve tension, promote sleep and meditation, and have obvious effects on prolonging sleep time.

下面采用SPSS统计软件中的配对样本T-检验的方法,进行用油前后的对比分析,看其有无显著性差异:The following uses the paired sample T-test method in the SPSS statistical software to conduct a comparative analysis before and after oil use to see if there is a significant difference:

表2配对T-检验结果-配对样本检验Table 2 Paired T-test results - paired sample test

双尾检验概率P=0.000<0.001,故可以认为吸溴复合精油之后的睡眠时间极显著延长Two-tailed test probability P=0.000<0.001, so it can be considered that the sleep time after inhaling bromine compound essential oil is extremely significantly prolonged

从表2可以看出,经过检验过后,可以认为吸溴复合精油之后的睡眠时间极显著延长,而且本发明实施例的精油适用于入睡困难,多梦,易醒,白天精神不佳者所居住的环境中进行使用。As can be seen from Table 2, after the test, it can be considered that the sleep time after inhaling the bromine compound essential oil is extremely significantly extended, and the essential oil of the embodiment of the present invention is suitable for people who have difficulty falling asleep, dreamy, easy to wake up, and poor spirits during the day. environment for use.

尽管已用具体实施例来说明和描述了本发明,然而应意识到,在不背离本发明的精神和范围的情况下可以作出许多其它的更改和修改。因此,这意味着在所附权利要求中包括属于本发明范围内的所有这些变化和修改。While particular embodiments of the invention have been illustrated and described, it should be appreciated that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (10)

1.一种安神促眠的精油,其特征在于,主要由以下原料制成:以体积份数计,柠檬精油30-80份,薰衣草精油0-50份,罗马甘菊精油0-30份,安息香精油0-30份。1. an essential oil for calming the nerves and promoting sleep, characterized in that it is mainly made of the following raw materials: in parts by volume, 30-80 parts of lemon essential oil, 0-50 parts of lavender essential oil, 0-30 parts of Roman chamomile essential oil, Benzoin essential oil 0-30 parts. 2.根据权利要求1所述的一种安神促眠的精油,其特征在于,主要由以下原料制成:以体积份数计,柠檬精油50-80份,薰衣草精油10-30份,罗马甘菊精油5-10份,安息香精油5-10份。2. a kind of sedative and sleep-promoting essential oil according to claim 1, is characterized in that, mainly is made of following raw material: in parts by volume, 50-80 parts of lemon essential oil, 10-30 parts of lavender essential oil, romagan Chrysanthemum essential oil 5-10 parts, benzoin essential oil 5-10 parts. 3.根据权利要求1所述的一种安神促眠的精油,其特征在于,主要由以下原料制成:以体积份数计,柠檬精油60-70份,薰衣草精油15-35份,罗马甘菊精油8-10份,安息香精油8-10份。3. a kind of essential oil for calming the nerves and promoting sleep according to claim 1, is characterized in that, mainly is made of following raw material: in parts by volume, 60-70 parts of lemon essential oils, 15-35 parts of lavender essential oils, romagan Chrysanthemum essential oil 8-10 parts, benzoin essential oil 8-10 parts. 4.根据权利要求1所述的一种安神促眠的精油,其特征在于,所述柠檬精油的主要成份如下:以体积百分比计,柠檬烯50-60%、γ-松油烯10-20%、β-蒎烯10-20%。4. a kind of sedative and sleep-promoting essential oil according to claim 1, is characterized in that, the main component of described lemon essential oil is as follows: by volume percentage, limonene 50-60%, gamma-terpinene 10-20% , β-pinene 10-20%. 5.根据权利要求1所述的一种安神促眠的精油,其特征在于,所述薰衣草精油的主要成份如下:以体积百分比计,芳樟醇35-45%,乙酸芳樟醇20-30%、乙酸薰衣草酯10-25%,α-松油醇4-15%。5. a kind of sedative and sleep-promoting essential oil according to claim 1, is characterized in that, the main component of described lavender essential oil is as follows: by volume percentage, linalool 35-45%, linalool acetate 20-30% %, lavender acetate 10-25%, α-terpineol 4-15%. 6.根据权利要求1所述的一种安神促眠的精油,其特征在于,所述罗马甘菊精油的主要成份为异丙基萘。6. a kind of essential oil for calming the nerves and promoting sleep according to claim 1, is characterized in that, the main component of described Roman chamomile essential oil is isopropyl naphthalene. 7.根据权利要求1所述的一种安神促眠的精油,其特征在于,所述安息香精油的主要成份如下:以体积百分比计,3-苯基-2-丙烯醛40-50%、肉桂酸苄酯40-50%、苯甲酸苄脂8-15%。7. a kind of sedative and sleep-promoting essential oil according to claim 1, is characterized in that, the main component of described benzoin essential oil is as follows: by volume percentage, 3-phenyl-2-propenal 40-50%, cinnamon Benzyl benzoate 40-50%, benzyl benzoate 8-15%. 8.根据权利要求1-7任一项所述的安神促眠的精油,其特征在于,所述柠檬精油的提取方法为从柠檬果皮中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得;8. according to the sedative essential oil described in any one of claim 1-7, it is characterized in that, the extraction method of described lemon quintessential oil is to adopt steam distillation method, squeezing method, extraction method, carbon dioxide critical oil from lemon peel. It is obtained by extracting the essence by any method in the extraction method; 优选所述薰衣草精油的提取方法为从薰衣草全草中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得;Preferably, the extraction method of the lavender essential oil is obtained by extracting the essence from the whole lavender by any method of steam distillation, pressing, extraction, and carbon dioxide critical extraction; 优选所述罗马甘菊精油的提取方法为从甘菊中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得;Preferably, the extraction method of the Roman chamomile essential oil is obtained by extracting the essence from chamomile by any method of steam distillation, pressing, extraction, and carbon dioxide critical extraction; 优选所述安息香精油的提取方法为从安息香花中采用水蒸气蒸馏法、压榨法、萃取法、二氧化碳临界萃取法中的任意一种方法提取精华物质所得。Preferably, the extraction method of the benzoin essential oil is obtained by extracting the essence from the benzoin flowers by any method of steam distillation, pressing, extraction, and carbon dioxide critical extraction. 9.权利要求1-8任一项所述的安神促眠的精油的制备方法,其特征在于,包括如下步骤:将所述柠檬精油、薰衣草精油、罗马甘菊精油以及所述安息香精油混合均匀,即得。9. The preparation method of the sedative and sleep-promoting essential oil described in any one of claims 1-8, is characterized in that, comprises the steps: mixing described lemon essential oil, lavender essential oil, Roman chamomile essential oil and described benzoin essential oil , that is. 10.根据权利要求9所述的安神促眠的精油的制备方法,其特征在于,将所述柠檬精油、薰衣草精油、罗马甘菊精油以及所述安息香精油混合搅拌均匀后,还包括制备成固体凝胶状的步骤。10. the preparation method of the essential oil of calming the nerves and promoting sleep according to claim 9, is characterized in that, after described lemon essential oil, lavender essential oil, Roman chamomile essential oil and described benzoin essential oil are mixed and stirred evenly, also comprise preparing into solid Gel-like steps.
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CN107144685A (en) * 2017-05-27 2017-09-08 无限极(中国)有限公司 A kind of screening technique with refreshing effect essential oil or its product
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CN105213541A (en) * 2015-09-29 2016-01-06 宗欣生态科技(上海)有限公司 Rose compound essential oil improving insomnia due to pressure and preparation method thereof
CN105213541B (en) * 2015-09-29 2019-03-19 宗欣生态科技(上海)有限公司 Improve the Rose compound essential oil and preparation method thereof of insomnia due to pressure
CN106880709A (en) * 2017-03-30 2017-06-23 厦门正合意生物科技有限公司 A kind of relieving insomnia for improving brain wave helps the composite essential oil of sleep
CN107144685A (en) * 2017-05-27 2017-09-08 无限极(中国)有限公司 A kind of screening technique with refreshing effect essential oil or its product
CN107144685B (en) * 2017-05-27 2018-11-09 无限极(中国)有限公司 A kind of screening technique with refreshing effect essential oil or its product
EP3485894A1 (en) * 2017-11-20 2019-05-22 Italfarmaco SpA Combination of officinal plants and their use in the treatment and/or prevention of sleep disorders
CN110292573A (en) * 2019-06-12 2019-10-01 颇黎芳香医药科技(上海)有限公司 A kind of relieve stagnation sleeping compound essential oil
CN110292573B (en) * 2019-06-12 2022-07-22 颇黎芳香医药科技(上海)有限公司 Depression-relieving and sleep-aiding compound essential oil
CN111317753A (en) * 2020-03-11 2020-06-23 北京茂思商贸有限公司 Plant essential oil composition with effects of calming and helping sleep and preparation method thereof
CN112121095A (en) * 2020-08-19 2020-12-25 歌曼丽(苏州)大健康产业发展有限公司 Hypnotic essential oil composition with quick response and preparation method thereof
CN111973672A (en) * 2020-09-11 2020-11-24 杜浩 Sleep-aiding composition and preparation method thereof
CN113604280A (en) * 2021-07-19 2021-11-05 上海应用技术大学 Lavender compound essential oil, preparation method and evaluation method thereof
CN114129630A (en) * 2021-11-22 2022-03-04 河北泰城农业科技发展有限公司 Preparation method and application of essential oil composition for soothing nerves, helping sleep and recovering memory

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