CN111317753A - Plant essential oil composition with effects of calming and helping sleep and preparation method thereof - Google Patents
Plant essential oil composition with effects of calming and helping sleep and preparation method thereof Download PDFInfo
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- CN111317753A CN111317753A CN202010165683.1A CN202010165683A CN111317753A CN 111317753 A CN111317753 A CN 111317753A CN 202010165683 A CN202010165683 A CN 202010165683A CN 111317753 A CN111317753 A CN 111317753A
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- essential oil
- lavender
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- 230000007958 sleep Effects 0.000 title claims description 38
- 230000000694 effects Effects 0.000 title abstract description 30
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- 238000002360 preparation method Methods 0.000 title description 10
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- GGHMUJBZYLPWFD-UHFFFAOYSA-N patchoulialcohol Chemical compound C1CC2(C)C3(O)CCC(C)C2CC1C3(C)C GGHMUJBZYLPWFD-UHFFFAOYSA-N 0.000 description 2
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- LAAPRQODJPXAHC-UHFFFAOYSA-N Coniferyl benzoate Natural products C1=C(O)C(OC)=CC(C=CCOC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-UHFFFAOYSA-N 0.000 description 1
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- OJYKYCDSGQGTRJ-GQYWAMEOSA-N beta-santalol Chemical compound C1C[C@H]2C(=C)[C@@](CC/C=C(CO)/C)(C)[C@@H]1C2 OJYKYCDSGQGTRJ-GQYWAMEOSA-N 0.000 description 1
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- LAAPRQODJPXAHC-AATRIKPKSA-N coniferyl benzoate Chemical compound C1=C(O)C(OC)=CC(\C=C\COC(=O)C=2C=CC=CC=2)=C1 LAAPRQODJPXAHC-AATRIKPKSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/022—Refining
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a plant essential oil composition with sedative and sleep-aiding effects, which comprises lavender essential oil; the lavender essential oil is extracted from south-method Provence lavender by a water distillation method. According to the invention, the real lavender growing at the elevation of 1000-1200 m in the French Provence region is selected, extracted by an overwater distillation method, and then purified by combining molecular distillation to prepare the lavender oil without 1, 8-cineole, camphor, borneol and other components, wherein the main components are linalool, linalyl acetate, lavender acetate and the like.
Description
Technical Field
The invention relates to the field of essential oil nerve calming, in particular to a plant essential oil composition with functions of calming and sleep aiding and a preparation method thereof.
Background
Sleep is an indispensable physiological requirement of a human being and one of the instinctive behaviors of a human being. One third of the life of a person is used for sleeping, which plays an important role in ensuring the normality and stability of various physiological functions of the body. With the increasing pressure of modern society, the insomnia phenomenon generally occurs, the incidence rate of insomnia is increased year by year, and the sleep problem becomes a social hotspot problem which is widely existed and is concerned.
According to the investigation of the world health organization, about 1/3 people have sleep disorders worldwide, and the proportion of people suffering from various sleep disorders in China is 38.2 percent and is higher than the global level. The chinese physician association sleep medical professional committee published the relevant research reports to the media on a near day basis. The study showed a mean + value of sleep score after 90 of 66.26 points; the common sleeping is not good.
Common sleep problems are manifested by shallow sleep, slow falling asleep, difficulty falling asleep, and fatigue after waking up. The sleep quality is reduced, so that people are easy to fatigue, have poor spirit and are difficult to concentrate in scenes such as life and work of the next day, and in some specific occupations, serious accidents can be caused. Long-term past sleep disorders may also lead to a decline in body function and complications caused thereby, seriously affecting the health of the body.
The sleep is clinically treated by using sedative hypnotic and anxiolytic drugs, so that the sleep time of a patient is shortened, and the waking frequency in sleep is reduced, thereby rapidly relieving the insomnia symptom and achieving the treatment effect. Modern medical research shows that: the use of sedative hypnotic and anxiolytic drugs can prolong the light sleep time of insomniacs, reduce slow wave sleep and quick eye movement sleep, and shows that the drugs can prolong the sleep time of patients, but cannot fundamentally improve the sleep quality and relieve fatigue. Moreover, the two medicines can generate drug resistance, addiction and other side effects and adverse reactions after being taken for a long time; some patients increase the dosage by themselves under the condition of non-compliance with the medical advice due to the drug resistance of the drugs, so that the illness state cannot be controlled if the dosage is larger, and the illness state is aggravated; both of these two drugs cannot be stopped suddenly, and there will be rebound disease after stopping taking the drug, and even anxiety reaction and mental symptoms of different degrees.
Natural plant essential oil has been used for soothing nerves and helping sleep for a long time, and people often burn vanilla to keep good health and feel happy, soothe nerves and help sleep as early as ancient times. In modern society, Aromatherapy (Aromatherapy) is an effective method for regulating body and mind and relieving stress. Lavender oil is most commonly used in aromatherapy, and its fragrance is believed to contribute to health and calmness. It is reported in the literature that it also has a stress, anxiety, or even mild pain relieving effect. In the aspect of relieving sleep disorder, the lavender essential oil is also applied very much, and a large number of sleep-assisting products developed by depending on the lavender oil are available in the market, and comprise products such as aromatherapy, perfume, sleep-assisting pillows and the like. CN106539724A discloses a lavender perfume for soothing nerves and aiding sleep, which comprises the following components: lavender hydrosol, lily hydrosol, linden jacquard hydrosol, chamomile hydrosol, marjoram hydrosol, elderberry hydrosol, orange flower essential oil tincture, thyme essential oil tincture and frankincense essential oil tincture.
According to market research on lavender essential oil sleep-aiding products, the feedback of a lot of consumers is found, and the effects of soothing the nerves and aiding sleep are not achieved but the refreshing effect is achieved when the lavender essential oil is used. Through research on literature data, the common lavender comprises real lavender, striking lavender and spicate lavender, and essential oils of different lavender varieties are greatly different in components. The same lavender has larger difference of essential oil components along with the difference of soil components, climate conditions, growing season, harvesting time and storage and transportation conditions. In addition, the same lavender and the same growth environment have larger difference in the components of the essential oil due to the difference of the extraction and purification processes. The difference of the components causes different effects of the essential oil, and some lavender essential oil has the effects of calming and helping sleep, and some lavender essential oil has the effect of refreshing mind.
Disclosure of Invention
In view of the above situation, the present invention provides a plant essential oil composition, which comprises lavender essential oil and an odor blending component, wherein the odor blending component is at least one selected from the group consisting of chamomile oil, vetiver oil, patchouli oil and bergamot fruit oil.
In one embodiment of the present invention, the camomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil are in the same weight parts.
As an embodiment of the present invention, the composition further comprises an odor stabilizing ingredient selected from at least one of sandalwood oil, benzoin oil, mastic oil.
In one embodiment of the present invention, the sandalwood oil, benzoin oil and mastic oil are in the same weight parts.
As one embodiment of the invention, the weight ratio of the odor blending component to the lavender essential oil is (5-20): (70-90).
As one embodiment of the invention, the weight ratio of the odor stabilizing component to the lavender essential oil is (5-15): (70-90).
As an embodiment of the present invention, the lavender essential oil is extracted from real lavender of south faropenia by a water distillation method.
As an embodiment of the present invention, the lavender essential oil is prepared by the following method:
1) extracting by adopting an overwater distillation method, distilling for 2-3 h, collecting condensate, standing for layering, and collecting an upper oil phase;
2) purifying by molecular distillation, and collecting heavy components to obtain oleum Lavandula Angustifolia.
As an embodiment of the invention, in the molecular distillation purification in the step 2), the distillation temperature is 40-50 ℃, the distillation pressure is 60-80Pa, and the rotating speed of the wiped film is 200--1。
The second aspect of the invention provides the plant essential oil composition, which is used in the fields of sedation and sleep assistance.
Has the advantages that:
1. according to the invention, the real lavender growing at the elevation of 1000-1200 m in the French Provence region is selected, extracted by an overwater distillation method, and then purified by combining molecular distillation to prepare the lavender oil without 1, 8-cineole, camphor, borneol and other components, wherein the main components are linalool, linalyl acetate, lavender acetate and the like;
2. the manifestations of insomnia mainly include several aspects of difficulty in falling asleep, poor sleep quality, short sleep time and the like, and a single essential oil is single for relieving symptoms. The moods such as tension, anxiety, fear and excitation are the main reasons for the difficulty in falling asleep, and the lavender oil, the chamomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil can be mutually matched to relieve the moods, the spirits such as mental tension and fear and help to fall asleep quickly; the sandalwood oil, benzoin oil and frankincense oil can help to regulate a respiratory system and a circulatory system, promote deep sleep and improve sleep quality. The unique advantages of various essential oils are fully exerted, and the sleep quality is synergistically improved.
3. Because lavender oil has low human acceptance, the lavender oil needs blending of other plant essential oils to improve the odor. According to the invention, the lavender oil, the sandalwood oil, the chamomile oil, the frankincense oil, the vetiver oil, the patchouli oil, the benzoin oil and the bergamot fruit oil are selected to be matched according to a certain proportion, the effects of calming and relieving are achieved, the fragrance of the compound essential oil is fresh and pleasant, and the market research shows that the product essential oil has wide market acceptance.
4, the preparation method is simple, has wide market prospect and is suitable for large-scale production.
Detailed Description
The present invention will be described in more detail with reference to the following examples. The technical solutions in the embodiments of the present invention are clearly described, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by those skilled in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
In view of the above situation, the present invention provides a plant essential oil composition with sedative and sleep-improving effects, which comprises lavender essential oil;
the lavender essential oil is extracted from real lavender of south Fanfo Wang by a water distillation method.
In the invention, the lavender is selected from lavender growing at the elevation of 1000-1200 m in the French Provence region.
The preparation method of the lavender essential oil comprises the following steps:
1) extracting by adopting an overwater distillation method, distilling for 2-3 h, collecting condensate, standing for layering, and collecting an upper oil phase;
2) purifying by molecular distillation, and collecting heavy components to obtain oleum Lavandula Angustifolia.
As an embodiment of the present invention, the stepsIn the molecular distillation purification in the step 2), the distillation temperature is 40-50 ℃, the distillation pressure is 60-80Pa, and the rotating speed of the scraping film is 200--1。
According to the invention, the real lavender growing at the elevation of 1000-1200 m in the French Provence region is selected, and extracted by an overwater distillation method to obtain the lavender oil, the main components of the lavender oil are linalool, linalyl acetate, lavender ester acetate and coumarin components, and trace acetophenone components in the components are combined, so that the lavender oil can effectively smooth the thinking, soothe the nerves and center and help sleep. In addition, by molecular distillation and purification, the components with refreshing effect in oleum Lavandula Angustifolia including 1, 8-cineole, Camphora, Borneolum Syntheticum, etc. are reduced. The lavender oil prepared by the invention has very good effects of calming and helping sleep.
As an embodiment of the present invention, the lavender essential oil contains 1, 8-cineole in an amount of less than 0.2 wt.%; the content of Camphora and Borneolum Syntheticum is almost 0.
Odor harmonizing component
As an embodiment of the present invention, the composition further comprises an odor-blending component selected from at least one of chamomile oil, vetiver oil, patchouli oil, bergamot fruit oil.
The chamomile oil with white flowers belongs to the Roman chamomile essential oil, has the effects of calming, soothing and relaxing due to the unique aroma of 'ripe apples', and can relieve anxiety, mental stress, fear and the like when being matched with lavender. Helps to relieve dreaminess and light sleep.
Vetiver oil is rich in triploid sesquiterpene molecules and special vetiverol components, can release deep pressure and confusion, and is the first choice of 'sedative essential oil'. The sleep quality is improved by adjusting the nervous system of the human body, and the body and mind are adjusted to the optimal position.
The patchouli essential oil contains special patchouli alcohol components, and can stabilize mood, promote blood circulation, soothe nervous system, soothe restlessness and bring a gentle mood.
The bergamot fruit oil contains a special coumarin component, linalyl acetate with high appeasing property, warm flower fragrance, relaxation emotion and deepest decompression of soul, and the bergamot is also a catalyst in the essential oil and can enable all the essential oils to generate stronger synergistic effect together.
In one embodiment of the present invention, the camomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil are in the same weight parts.
As one embodiment of the invention, the weight ratio of the odor blending component to the lavender essential oil is (5-20): (70-90).
Odor stabilizing ingredient
As an embodiment of the present invention, the composition further comprises an odor stabilizing ingredient selected from at least one of sandalwood oil, benzoin oil, mastic oil.
The sandalwood essential oil is selected from tree core woods with the age of 50 years, the precious β santalol content can reach the highest point in the variety, and the sandalwood essential oil can stabilize mood, center and concentrate mind.
The Olibanum essential oil is rich in esters, including Acrolyl acetate, n-octyl acetate, and the synergistic effect of the dihydric alcohol, monoterpene and esters, and can make the breath gradually deep and slow. Help to relieve the negative emotions of impatience, frustration and the like. Soothe the restless heart and make the depth of the human body calm and relax.
The special phenyl ester of the benzoin essential oil, coniferyl benzoate, in cooperation with aromatic aldehyde substances in the benzoin, can give a feeling of hugging of warmth, fragrance and sweetness, nourish the thoughts and souls of lonely.
In one embodiment of the present invention, the sandalwood oil, benzoin oil and mastic oil are in the same weight parts.
As one embodiment of the invention, the weight ratio of the odor stabilizing component to the lavender essential oil is (5-15): (70-90).
Lavender is native to the coast of the Mediterranean sea, every Europe and the islands of oceania, is introduced into China only in the 60 s of the 20 th century, and is planted in only partial regions of China. Different from the situation that people in Mediterranean regions are subjected to lavender odor from childhood, the market acceptance of the lavender odor in China is narrow, and a large number of market consumers cannot accept the lavender odor through market research. According to the invention, through a large number of experiments, the ingredients of the chamomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil are added to adjust the odor of the lavender essential oil, so that the odor is fresh and pleasant, and the market acceptance is greatly improved. Meanwhile, the herbal essential oils of the white flowered poncirus flower oil, the vetiver oil, the patchouli oil and the bergamot fruit oil have the effects of calming nerves and relieving emotion, and can help a patient to quickly fall asleep.
In addition, the essential oil components of the lavender oil, the chamomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil are mainly monoterpenes and sesquiterpenes, and the essential oil components have high volatilization speed, strong smell and no persistence. On the basis of adding the herbal essential oil, the woody plant essential oil such as sandalwood oil, benzoin oil and mastic oil is added, the ester component is mainly used, the volatilization speed is low, and the effects of regulating the volatilization speed of the essential oil and stabilizing the smell are achieved. And the woody plant essential oils such as sandalwood oil, benzoin oil and mastic oil can effectively regulate the respiratory system and the circulatory system of the human body, promote deep sleep and improve the sleep quality.
In the present invention, components not specifically mentioned are commercially available.
The present invention will be described in detail with reference to specific examples.
Example 1:
the preparation method of the lavender oil comprises the following steps:
1) lavender (place of origin: south Farpownss, elevation 1000-;
2) extracting by water distillation (water-proof distillation), distilling for 2.5h, collecting condensate, standing for layering, and collecting upper oil phase;
3) performing molecular distillation and purification (the distillation temperature is 45 ℃, the distillation pressure is 70Pa, and the film scraping rotation speed is 250 r.min < -1 >), and collecting heavy components to obtain the lavender oil.
Example 2:
the preparation method of the lavender oil comprises the following steps:
1) lavender (place of origin: yili, xinjiang, china);
2) extracting by water distillation (water-proof distillation), distilling for 2.5h, collecting condensate, standing for layering, and collecting upper oil phase;
3) performing molecular distillation and purification (the distillation temperature is 45 ℃, the distillation pressure is 70Pa, and the film scraping rotation speed is 250 r.min < -1 >), and collecting heavy components to obtain the lavender oil.
Example 3:
the preparation method of the lavender oil comprises the following steps:
1) lavender (place of origin: the producing area: south Farpownss, elevation 1000-;
2) extracting by water distillation (water-proof distillation), distilling for 2.5h, collecting condensate, standing for layering, and collecting upper oil phase;
3) performing molecular distillation and purification (the distillation temperature is 30 ℃, the distillation pressure is 70Pa, and the film scraping rotation speed is 250 r.min < -1 >), and collecting heavy components to obtain the lavender oil.
Example 4:
the preparation method of the lavender oil comprises the following steps:
1) lavender (place of origin: south Farpownss, elevation 1000-;
2) extracting by water distillation (water-proof distillation), distilling for 2.5h, collecting condensate, standing for layering, and collecting upper oil phase;
3) performing molecular distillation and purification (the distillation temperature is 45 ℃, the distillation pressure is 50Pa, and the film scraping rotation speed is 250 r.min < -1 >), and collecting heavy components to obtain the lavender oil.
Firstly, detecting the components of lavender oil
The ingredients of the lavender are analyzed by GC, a chromatographic column is an Agilent HP-INNOWAx (30m × 0.25.25 mm × 0.25.25 mu m) capillary column, the injection port temperature is 200 ℃, carrier gas is helium, the flow rate is 1mL/min, the injection amount is 0.4 mu L, the split ratio is 1: 100, the temperature rising program is that the initial temperature is 70 ℃, the initial temperature is kept for 16min, then the temperature is raised to 180 ℃ at the speed of 2 ℃/min, the temperature of a hydrogen flame ionization detector is 200 ℃, and the relative mass fraction of each main ingredient is calculated by adopting a peak area normalization method.
| Preparation example | Linalool | Linalyl acetate | Lavender acetate | 1, 8-cineole | Camphor |
| Example 1 | 46.17％ | 34.62％ | 9.58％ | 0.18％ | 0 |
| Example 2 | 46.92％ | 27.69％ | 6.15％ | 2.76％ | 0 |
| Example 3 | 49.14％ | 26.93％ | 6.62％ | 3.25％ | 0.32％ |
| Example 4 | 48.32％ | 28.37％ | 7.56％ | 3.12％ | 0.48％ |
Example 5:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 6:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 7:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of white flower chamomile oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 8:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 9:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 10:
the embodiment provides a plant essential oil composition with effects of calming and helping sleep, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 11:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 12:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil and 5 parts of benzoin essential oil.
The lavender oil was obtained in the same manner as in example 1.
Example 13:
the embodiment provides a plant essential oil composition with calming and sleep-helping effects, which comprises 85 parts of lavender oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil, 5 parts of sandalwood essential oil, 5 parts of benzoin essential oil and 5 parts of frankincense oil.
The lavender oil was obtained in the same manner as in example 1.
Example 14:
the embodiment provides a plant essential oil composition with sedative and sleep-aiding effects, which comprises 85 parts of lavender oil, 5 parts of sandalwood essential oil and 5 parts of benzoin essential oil.
The lavender oil was obtained in the same manner as in example 1.
Example 15:
the embodiment provides a plant essential oil composition with effects of calming and helping sleep, which comprises 85 parts of lavender oil, 5 parts of chamomile oil, 5 parts of vetiver oil, 5 parts of patchouli oil, 5 parts of bergamot fruit oil and 5 parts of sandalwood essential oil.
The lavender oil was obtained in the same manner as in example 1.
And (3) testing:
subjective perception test
The questionnaire survey is combined with an online questionnaire (wider coverage range) and an offline questionnaire (more essential oil for the research population), 362 volunteers are registered in the survey, and after comparison and screening are carried out on a personal condition registration form (filling contents comprise name, age, sex, address, sleep quality condition, allergy or allergy history and the like) filled by all the registrants, 150 subjects with different degrees of sleep quality problems are finally selected to participate in the survey. Wherein 84 males and 66 females have ages of 21-40 years, and the average age is 27.38 years.
In the bedroom of the subject, a drop of essential oil composition (theoretical 0.05 ml/drop) is dropped into 50ml of warm water at 40 ℃, then the essential oil composition is added into the aromatherapy machine, the aromatherapy machine is opened 10min before the subject enters, the subject enters the smelling room for experience for 30min, and then the questionnaire is filled out according to actual conditions.
| Test index | Standard of merit | Scoring |
| Fragrance | Subjective preference for aroma | 1 (poor) -5 (good) |
| Comfort of use | Subjective comfort after use of a product | 1 (none) -5 (with obvious action) |
| Relieve the mind and body | Subjective stress and mood relief perception | 1 (none) -5 (with, great effect) |
The test results were as follows:
| group of | Fragrance | Comfort level | Relieving pressure | Average |
| Example 5 | 4.14 | 3.78 | 3.46 | 3.79 |
| Example 6 | 3.28 | 3.62 | 3.38 | 3.42 |
| Example 7 | 3.48 | 3.27 | 3.41 | 3.39 |
| Example 8 | 3.93 | 3.46 | 3.68 | 3.69 |
| Example 9 | 3.43 | 3.44 | 2.71 | 3.19 |
| Example 10 | 4.05 | 3.36 | 3.26 | 3.56 |
| Example 11 | 3.47 | 3.17 | 3.41 | 3.35 |
| Example 12 | 3.65 | 3.52 | 3.28 | 3.48 |
| Example 13 | 2.42 | 2.40 | 2.68 | 2.50 |
| Example 14 | 2.17 | 2.48 | 2.19 | 2.28 |
| Example 15 | 2.66 | 2.72 | 2.64 | 2.67 |
Subjective sleep-aid test
And subjectively judging the improvement condition of the compound essential oil on the sleep quality of the human by adopting a Pittsburgh sleep index scale (PSQI). PSQI was compiled in 1989 by doctor Buysse et al, university of pittsburgh, usa, and is an authoritative international common sleep laboratory assessment scale. When the score of the table is reduced by more than or equal to 3 points, the subjective sleep quality is judged to be improved.
All subjects in this study were enrolled by voluntary enrollment, mainly from guangzhou multi-dwelling biotech, inc. After the personal condition registration forms (filling contents comprise name, age, sex, address, sleep quality condition, allergy history and the like) filled by all the registration personnel are screened by comparison, 33 persons are finally selected as volunteers, wherein 8 persons are male, 12 persons are female, the age is 21-40 years, and the average is (26.9 +/-3.1). Subjects were randomized into 11 groups of 3 subjects each.
In the bedroom of the testee, a drop of essential oil (theoretical 0.05 ml/drop) is dropped into 50ml of warm water at 40 ℃, then the essential oil is added into the aromatherapy machine, and the aromatherapy machine is opened 1h before the testee normally works and sleeps for a test period. Before the test is started and after the test is finished, all the subjects are required to complete the same Pittsburgh sleep quality index questionnaire according to actual conditions.
PSQI value variation
| Group of | Before testing | After the test |
| Example 5 | 13.4 | 6.6 |
| Example 6 | 16.1 | 11.4 |
| Example 7 | 14.5 | 9.9 |
| Example 8 | 15.8 | 10.5 |
| Example 9 | 16.4 | 11.3 |
| Example 10 | 17.6 | 12.8 |
| Example 11 | 14.5 | 9.6 |
| Example 12 | 16.3 | 11.8 |
| Example 13 | 17.6 | 12.4 |
| Example 14 | 16.2 | 13.9 |
| Example 5 | 15.6 | 12.6 |
And (3) scoring the pitasburg sleep index scale, wherein the pitasburg sleep index scale is a common sleep experiment evaluation scale in the world, and if the score of the table is reduced by more than or equal to 3, the subjective sleep is improved. From the results of this study, the subjects of examples 5-10 all had different degrees of improvement in sleep quality after product use, with the improvement seen most clearly in example 5.
Objective sleep-aiding test
By utilizing sleep electroencephalogram test, the percentage change conditions of β and α waves, α and theta waves in the sleep stage (S1-30min), theta waves in the latent sleep stage (S2-30min) and delta waves in the medium-deep sleep stage (S3-30min) before and after the testee smells and inhales essential oil are observed.
In the residential area near the third hospital affiliated to the university of Zhongshan, the volunteers for the sleep experiment were recruited, and in total, 36 volunteers were named, and 11 subjects were finally selected according to the Pittsburgh sleep quality index Scale (PQSI) score of 11-16 (indicating poor sleep quality), wherein 3 were male, 3 were female, and the age was 21-40.
According to the brain wave change rule of clinical sleep brain wave research, the judgment standard is that β wave reduction percentage is more than or equal to 2% in the sleep period (wake-30min), α wave increase percentage is more than or equal to 2% in the sleep period (S1-30min), α wave reduction percentage is more than or equal to 2% in the sleep period (S1-30min), theta wave increase percentage is more than or equal to 2% in the theta wave increase percentage is effective, theta wave increase percentage is more than or equal to 2% in the latent sleep period (S2-30min), delta wave increase percentage is more than or equal to 2% in the medium-deep sleep period (S3-30min), and objective sleep quality is considered to be improved when 4 brain wave change amounts are more than.
Claims (9)
1. A plant essential oil composition, comprising:
lavender essential oil; and
at least one of an odor-blending component and an odor-stabilizing component.
2. The plant essential oil composition as claimed in claim 1, wherein the odor blending component is at least one selected from the group consisting of chamomile oil, vetiver oil, patchouli oil, bergamot fruit oil,
preferably, the weight parts of the chamomile oil, the vetiver oil, the patchouli oil and the bergamot fruit oil are the same.
3. A plant essential oil composition according to claim 1 or 2, wherein the odor stabilizing component is at least one selected from the group consisting of sandalwood oil, benzoin oil, mastic oil,
preferably, the sandalwood oil, benzoin oil and mastic oil are in the same weight part.
4. A plant essential oil composition according to any one of claims 1 to 3, wherein the weight ratio of the odor blending component to the lavender essential oil is (5-20): (70-90).
5. A plant essential oil composition according to any one of claims 1 to 4, wherein the ratio of the odor stabilizing component to the lavender essential oil in parts by weight is (5-15): (70-90).
6. A plant essential oil composition according to any one of claims 1 to 5, wherein the lavender essential oil is extracted from real lavender of south Fanfo Wang by distillation over water.
7. The plant essential oil composition as claimed in any one of claims 1 to 6, wherein the lavender essential oil is prepared by the following method:
1) extracting by adopting an overwater distillation method, distilling for 2-3 h, collecting condensate, standing for layering, and collecting an upper oil phase;
2) purifying by molecular distillation, and collecting heavy components to obtain oleum Lavandula Angustifolia.
8. The plant essential oil composition as claimed in claim 7, wherein the distillation temperature in the molecular distillation purification in the step 2) is 40-50 ℃, the distillation pressure is 60-80Pa, and the rotating speed of the wiped film is 200--1。
9. A plant essential oil composition according to any one of claims 1 to 8, which is used in the field of sedation and sleep aid.
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| CN113082171A (en) * | 2021-04-23 | 2021-07-09 | 花安堂生物科技集团有限公司 | Composition and sleep-aiding product containing black spruce extract |
| CN114652784A (en) * | 2022-03-28 | 2022-06-24 | 江西中医药大学 | Compound essential oil, preparation method thereof and product with sedative hypnotic and memory improving effects |
| CN116249456A (en) * | 2020-10-21 | 2023-06-09 | 三井农林株式会社 | Brain function improving agent |
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| CN114652784A (en) * | 2022-03-28 | 2022-06-24 | 江西中医药大学 | Compound essential oil, preparation method thereof and product with sedative hypnotic and memory improving effects |
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